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Alteplase

1) The document is a drug research form about aluminum hydroxide/Alteplase that provides information on its generic and trade names, classification, mechanism of action, indications, contraindications, side effects, drug interactions, dosing, and nursing considerations. 2) Aluminum hydroxide is an antacid that binds phosphate in the GI tract to lower phosphate levels and neutralizes gastric acid to treat ulcers. 3) It is contraindicated in severe abdominal pain and should be used cautiously in patients with hypercalcemia, hypophosphatemia, or who are pregnant or breastfeeding.

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mahmoud mohamed
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265 views3 pages

Alteplase

1) The document is a drug research form about aluminum hydroxide/Alteplase that provides information on its generic and trade names, classification, mechanism of action, indications, contraindications, side effects, drug interactions, dosing, and nursing considerations. 2) Aluminum hydroxide is an antacid that binds phosphate in the GI tract to lower phosphate levels and neutralizes gastric acid to treat ulcers. 3) It is contraindicated in severe abdominal pain and should be used cautiously in patients with hypercalcemia, hypophosphatemia, or who are pregnant or breastfeeding.

Uploaded by

mahmoud mohamed
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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Drug Research Form

Student Name:___ Mohamed Samy Eldeeb _____________________________


Date:__________________

Generic Name
aluminum hydroxide
Trade Name Alteplase

Class
Therapeutic: antiulcer agents, hypophosphate
Pharmacologic: antacids, phosphate binders
Action

Binds phosphate in the GI tract. Neutralizes


gastric
acid and inactivates pepsin.

Indication/s
Lowering of phosphate levels in patients with
chronic
renal failure. Adjunctive therapy in the treatment
of
peptic, duodenal, and gastric ulcers.
Hyperacidity, indigestion,
reflux esophagitis.

Contraindication/s

Contraindicated in: Severe abdominal pain of


unknown

Side effect/s

GI: constipation. F and E: hypophosphatemia.

Common interaction/s with


another medication/s Drug-Drug: Absorption of tetracyclines,
chlorpromazine,
iron salts, isoniazid, digoxin, or
fluoroquinolones may be decreased. Salicylate
blood levels may be decreased. Quinidine,
mexiletine,
and amphetamine levels may be increased if
enough antacid is ingested such that urine pH is
increased.
Route/s of administration with
dosage PO (Adults): 1.9–4.8 g (30–40 mL of regular
Drug Research Form

Student Name:___ Mohamed Samy Eldeeb _____________________________


Date:__________________

suspension
or 15–20 mL of concentrated suspension)
3–4 times daily.
PO (Children): 50–150 mg/kg/24 hr in 4–6
divided

Therapeutic level Half-life: Unknown.

Method/s of preparation and ROUTE ONSET PEAK DURATION


administration PO† hr–days days–wk days
PO‡ 15–30 min 30 min 30 min–3 hr

Nursing consideration/s /
precaution/s Severe abdominal pain of unknown
cause.
Use Cautiously in: Hypercalcemia;
Hypophosphatemia;
OB: Generally considered safe; chronic highdose
therapy should be avoided.

Patient / Family teaching

● Instruct patient to take aluminum hydroxide


exactly
as directed. If on a regular dosing schedule and
a
dose is missed, take as soon as remembered if
not
almost time for next dose; do not double doses.
● Advise patient not to take aluminum hydroxide
within 1–2 hr of other medications without
consulting
health care professional.
● Advise patients to check label for sodium
content.
Patients with HF or hypertension, or those on
sodium
restriction, should use low-sodium preparations.

Reference (Use APA Guidelines)


Drug Research Form

Student Name:___ Mohamed Samy Eldeeb _____________________________


Date:__________________

Checked by Clinical Instructor:________________________________________

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