DRUG STUDY
Generic Name: Gentamicin
Brand Name: Gentacare
Classification:
Therapeutic: Aminoglycoside antibiotic
Dosage, Frequency, and Route: 12 mg IV q 12 hrs
Mechanism of Action: Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal
subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell
membrane defective.
Desired Effect: To treat infection by stopping the growth of aerobic bacteria.
Nursing Responsibilities and Rationale:
Nursing Responsibilities Rationale
Safe and effective drug administration
1. Verify the doctor’s order ● To ensure and verify the right
procedure to the right patient.
2. Observe the 13 Rs of medication ● To prevent medication errors and
administration. ensure the patient's safety.
3. Perform hand hygiene before and ● To reduce the transmission of
after administration. microorganisms.
4. Assess for any allergies to any ● To prevent adverse reactions.
aminoglycosides; renal or hepatic
disease; preexisting hearing loss;
active infection with herpes, vaccinia,
varicella, fungal infections,
myobacterial infections (ophthalmic
preparations); myasthenia gravis;
parkinsonism; infant botulism;
lactation, pregnancy.
5. Administer the medication slowly. ● To prevent vein injury.
6. Always wash hands thoroughly and ● To prevent the spread of infection.
disinfect equipment (whirlpools,
electrotherapeutic devices,
treatment tables, and so forth).
7. Report any muscle weakness or ● To provide emergent interventions
paralysis that occurs following when adverse reactions occur.
injection of high doses to the
physician.
8. Monitor signs of hypersensitivity ● To provide emergent interventions
reactions, including pulmonary when adverse reactions occur.
symptoms (tightness in the throat
and chest, wheezing, cough dyspnea)
or skin reactions (rash, pruritus,
urticaria).