Cellular Respiration Glycolysis

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Cellular respiration consists of three main stages: Glycolysis (Energy Payoff Stage)

• Glycolysis The glycolysis energy payoff stage involves two key


• The citric acid cycle (Krebs cycle) reactions: converting 1,3-bisphosphoglycerate into
• The electron transport chain (ETC) 3-phosphoglycerate and phosphoenolpyruvate into
pyruvate, resulting in ATP and pyruvate, a crucial
metabolite in cellular processes.
The first Cell Respiration Phase/Stage

• Glycolysis (Energy Investment Phase) Stage 6: Triose phosphate dehydrogenase


TPD is an enzyme in glycolysis that converts
Requires the input of two ATP molecules per glyceraldehyde-3-phosphate to 1,3-
glucose molecule to get the process started. bisphosphoglycerate, generating NADH and
preparing 1,3-BPG for glycolysis, particularly ATP
production, by removing hydrogen atoms.
Stage 1: Hexokinase
Hexokinase is an enzyme that catalyzes the process
of phosphorylating glucose during glycolysis, Stage 7: Phosphoglycerokinase
transferring a phosphate group from ATP to Phosphoglycerokinase, also known as PGK, is an
glucose, consuming one ATP molecule, resulting in enzyme in glycolysis that converts 1,3-
glucose-6-phosphate. bisphosphoglycerate into 3-phosphoglycerate,
adenosine triphosphate (ATP), and adenosine
diphosphate, thereby generating energy.
Stage 2: Phosphoglucoisomerase
Glycolytic enzyme converts glucose-6-phosphate
into fructose-6-phosphate, transforming its Stage 8: Phosphoglyceromutase
molecular structure without ATP consumption or Phosphoglyceromutase is an enzyme in glycolysis
generation, preparing glucose-6-phosphate for that converts 3-phosphoglycerate to 2-
further processing. phosphoglycerate, preparing it for subsequent
glycolysis reactions by moving the phosphate group
within the molecule.
Stage 3: Phosphofructokinase
Phosphofructokinase (PFK) is a vital enzyme in
glycolysis, responsible for the phosphorylation of Stage 9: Enolase
fructose-6-phosphate to fructose-1,6- Enolase is a crucial enzyme in glycolysis, converting
bisphosphate, a key intermediate in the process, 2-phosphoglycerate into phosphoenolpyruvate
and regulates glycolysis rate based on cell energy (PEP), a high-energy product that is converted into
needs. pyruvate, producing ATP.

Stage 4: Aldolase Stage 10: Pyruvatekinase


Aldolase is an enzyme involved in glycolysis, Pyruvate kinase is an enzyme in glycolysis that
breaking down fructose-1,6-bisphosphate into two converts phosphoenolpyruvate (PEP) into pyruvate,
three-carbon molecules: G3P and DHAP, which are generating ATP and adenosine triphosphate (ATP),
then isomerized to continue the glycolysis which can be used in other metabolic pathways.
pathway.

Stage 5: Isomerase
Isomerases are enzymes that convert one isomer
into another, such as in glycolysis. They convert
DHAP into G3P, allowing both molecules to
continue through the glycolysis pathway, despite
different structural arrangements.

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