TM

Inflammation
DNA Health Report

REPORT CATEGORY

I MMUNE FUNC T I O N
& I NFL A MMAT I O N

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Report date: 23 January 2023
Table of
contents

How this works

Introduction

Your Genetics

Your Recommendations

DISCLAIMER

This report does not diagnose this or any other health conditions.
Please talk to a healthcare professional if this condition runs in
your family, you think you might have this condition, or you have
any concerns about your results.
How this works
Our Health Reports analyze how your DNA influences your health.
We then use this analysis to give you personalized risk estimates and recommendations.

Similarly, our Trait Reports look at how your DNA

influences your traits.

Your DNA is like an instruction manual — it contains a lot of information.

You can think of it as a blueprint for your body.

Genetic variants are parts of DNA that differ from person to person. Some can make you more vulnerable to certain
health issues, while others may influence traits such as eye color.

C T T G
C C
G T
C G A A
G A A A
G G A T
C G T A

C A
C T
A T

C A
We use artificial intelligence and machine learning to analyze all this information. We then In total, we analyze up to
summarize your results as a risk score or display it on a gauge. 83 million genetic
When we give a risk score, the risk icon tells you if you are at a higher or lower risk variants.
compared to other people:

15th

PERCEN TILE

Your risk is greater than 15% of the population

LOWER TY PICAL HIGHER and lower than 85% of the population.

Your risk is also displayed as a percentile. This will tell you how your risks compare to our sample population. The lower
your percentile number, the lower your risk. The "50th percentile" would be an average risk.

Similarly, the gauge tells you your relative risk score compared to our sample population, or it indicates a specific trait or
haplotype you are more likely to have based on your genetic variants.

When applicable, we also list top evidence-based recommendations that may help lower your risk.
The focus is on recommendations that may be of benefit to you, based on your genetics.

Our recommendations come in three categories: lifestyle, diet, and supplements.

The following icons tell you which category a recommendation falls into:

D I E TA R Y LIFESTY LE SU PPLEMEN T DRUG

Our team of scientists also ranks each recommendation.

We rank based on impact and the strength of evidence in the medical literature.

Impact shows how strongly a recommendation will affect your health in a certain area.
Evidence is how much scientific support there is for the recommendation. Rankings are from 1 to 5 (low to high):

I MPA C T E V I DE NC E

3/5 4/5
Impact
Impact scores range from 1-5. These scores reflect how much of an effect each recommendation can have. An impact
score of 5 predicts the biggest effect.

When a recommendation affects something we can measure, we use those measurements to assign the impact score. For
example, a recommendation that decreases cholesterol by 20% will have a higher impact score than one that decreases
it by 5%.

Some recommendations affect things that we cannot directly measure, like stress or mood. For these, the impact score is
based on how well they work relative to other recommendations and standard treatments. The best ones get the highest
scores.

If there is a lot of research that shows a recommendation works especially well for your genotype, the impact score gets
increased.

Recommendation Evidence Genotype-specific evidence

5/5 High-quality

Recommendations that are considered effective and Direct evidence that a recommendation helps more in
generally recommended by experts and medical people with your gene variant (many clinical trials, a
bodies. few large clinical trials, or a meta-analysis).

4/5 Medium-quality

Recommendations that are considered likely effective Direct evidence that a recommendation helps more in
and that have multiple independent meta-analyses people with your gene variant (a few clinical trials or
and a great many studies supporting them. one large clinical trial).

3/5 Low-quality

Recommendations that are considered possibly Direct evidence that a recommendation helps more in
effective and have many studies supporting them. people with your gene variant (a single clinical trial or
more trials with inconsistent results).

2/5
Indirect
Recommendations that have insufficient evidence,
with two or several clinical trials supporting them, or A recommendation may help more in people with
many studies but with ambiguous results. your gene variant because it targets a specific gene
or protein affected by your variant (e.g., MTHFR,
dopamine).
1/5

Recommendations that have insufficient evidence, In theory

with a single clinical trial, or with many studies most of
which didn’t find support for the recommendation. A recommendation may help more in people with
your gene variant because it targets a specific
mechanism affected by your variant (e.g.,
0/5 inflammation, oxidative stress).

No evidence in humans.
Some things to keep in mind:

The scores/gauges use the latest scientific studies. But they are not perfect and will change as the models improve.

Not everyone with risk variants will develop a health condition.

Genetics is not the whole story. Your health is most often a combination of genetics, lifestyle, and environmental
factors. Great news, as this means that you can often change your lifestyle to lower your risk.

Results might be more accurate for some ethnic groups than others. This depends on the studies used in each report.

People without risk variants can also develop health conditions.

It's important to work with your doctor to better understand your risks. Our reports do not diagnose or treat any health
condition. They are not a substitute for medical advice. If you're diagnosed with a certain health condition, follow your
doctor's advice.
Introduction
Inflammation is used by your body as a defense against invaders like bacteria and viruses. This process is
generally beneficial, but you can have too much of a good thing [R].

When inflammation goes on too long (becomes chronic), it begins to damage your body. Chronic inflammation
is linked to many diseases. Around the world, chronic inflammatory diseases, like diabetes and heart disease,
are responsible for 3 in 5 deaths [R].

The fact that chronic inflammation is invisible to the naked eye, coupled with the complexity of inflammatory
diseases, make it tricky to spot. To identify chronic inflammation, doctors typically test for markers like CRP [R].

It can seem pretty daunting that invisible inflammation could be putting your health at risk. After all, if you can’t
see or feel it, how can you prevent it?

Ultimately, there isn’t one guaranteed solution to chronic inflammation. But we can target it using hidden
weapons we all carry in our biological tool kit: our genes!

Genetics may influence your risk of excess inflammation or how well you respond to certain anti-inflammatory
techniques.

For example, if you happen to carry a particular variant of the TNF gene, you may see a greater benefit from
exercising [R, R].

You could also carry a particular variant of the IL6 gene, which may increase your susceptibility to inflammation
from being stressed [R].

By identifying whether you carry these variants and others, you can potentially lower your risk by taking
action like exercising or practicing relaxation.

This report focuses on the genetics of inflammation. Read more to find out:

How your genetics play a role in inflammation

Your genetic risk score based on over 9,000 genetic variants
Personalized recommendations based on your genetics
 T Y PICAL LIKE LIH OOD

About Inflammation
Key Takeaways:

● Genetic variants may impact cell function and L E S S L I K E LY M O R E L I K E LY

messaging, as
well as histamine levels.
● Risk factors include diet, exercise, life Reduced likelihood of
satisfaction, and your inflammation based on
genetics. 9,023 genetic variants
● Chronic inflammation may be linked to obesity, we looked at
diabetes,
heart disease, cancer, and mental health.
● Chronic inflammatory diseases like
diabetes and heart 6th
disease, are responsible for 3 in 5 deaths
worldwide. PERCEN TILE

Inflammation is an important biological process. It

protects the body from disease and damage. When Your risk is greater than 6% of the population
and lower than 94% of the population.
germs or other foreign substances enter the body,
white blood cells rush to the site. The area then gets
red, swollen, and warm. These changes help kill
pathogens and prepare the tissue to heal [R, R]. VA RI A NT S T H AT H AV E T H E B I GGE S T
I MPA C T O N YO UR GE NE T I C
PRE DI S PO S I T I O N
A common marker that helps measure inflammation is
C-reactive protein (CRP). High sensitivity CRP (hs- GENE SNP G EN OTY PE

CRP) in particular helps measure low-grade LEPR rs4394621 AA

inflammation. OR10J5 rs4131568 TT

OASL rs7305618 TT
CRP is produced in the liver. It helps recognize TC
FCRL6 rs113188187
disease-causing microbes and damaged cells that
APOE rs141622900 GA
need to be removed from the body. However, it may
NECTIN2 rs11668327 GC
also play a role in autoimmune disease [R, R].
CRP rs10494326 CC

CRP AA
Short-term inflammation is helpful. However, too rs11265260

much inflammation can be a bad thing [R, R, R, R]. OR10J5 rs115381557 CC

APCS rs11545897 CC

Chronic inflammation is linked to many diseases, LEPR rs6672331 GG

including: APCS rs12745083 CC

FCER1A rs115585839 GG
Autoimmune conditions [R, R] OR10J5 rs114530473 CC
Heart disease [R, R, R] CRP rs3093070 TT
Obesity [R, R] OR10J5 AA
rs41264481
Type 2 diabetes [R, R]
APOE rs7412 CC
Fibromyalgia [R, R]
FCER1A rs114272969 GG
Mental health conditions [R, R, R]
CLPTM1 rs117264457 GG
Cancer [R, R, R, R, R]
APOE rs147707133 CC

In 2014, an estimated 60% of Americans were living The number of "risk" variants in this table doesn't necessarily reflect your overall result.

with at least one chronic inflammatory condition [R].

Factors that may influence chronic inflammation

include [R, R, R]:
 Diet
Exercise
Life satisfaction
Genetics

Common strategies for reducing low-grade

inflammation include [R, R, R, R, R]:

Lifestyle changes
Diet changes
Weight management
Drugs targeting the underlying condition

Genetics may play an important role in inflammatory

conditions. Genes involved in inflammation may
influence [R, R, R, R, R, R]:

Immune messengers (STAT3, IL6, IL10)

Immune cell function (HLA-DRB1, PTPN22)
Histamine levels (AOC1, HNMT)
Your recommendations
Total of 21 recommendations

Your recommendations are prioritized according to the likelihood of it having an impact for you based on your
genetics, along with the amount of scientific evidence supporting the recommendation.

You’ll likely find common healthy recommendations at the top of the list because they are often the most
impactful and most researched.

Exercise
I MPA C T E V I DE NC E

4/5 5/5

Exercise can do wonders for your health. It can help you lose weight, improve your
heart health, boost your mood, and more [R].

There are many ways you can be active. You can walk, run, swim, dance, or play team
sports. Everything counts, and it's never too late to start!

Try getting a mix of cardio (at least 150 min/week) and strength training (2 times/week)
[R].

How Exercise Helps Reduce Inflammation

Regular, moderate exercise may reduce inflammation in people of all ages. Both
strength training and cardio may help. You can also combine both training types [R, R,
R, R, R, R].

Exercise may also reduce inflammation linked to chronic health conditions. These
include [R, R, R, R]:

High blood pressure

Obesity
Type 2 diabetes
Heart disease

Note that inflammation may briefly increase after intense exercise, such as running
or cycling [R, R, R].
 PE RS O NA LI Z E D T O YO UR GE NE S

Regular exercise is a great way to reduce inflammation by targeting many of

your gene variants at once [R].

Exercise may reduce inflammation more in people with your TNF gene
variant [R, R].

Long-term exercise may reduce inflammation more in people with your IL6
gene variant [R].

YO UR GE NE T I C VA RI A NT S

GENE SNP G EN OTY PE EVID EN CE

MICB rs1800629 GG

GENE SNP G EN OTY PE EVID EN CE

STEAP1B rs1800797 AG,GG

 2

Maintain a Healthy Weight

I MPA C T E V I DE NC E

4/5 5/5

People have a healthy weight when they don't have too much or too little body fat
[R].

Body mass index (BMI) can help determine body fat levels. Your BMI is your mass (in
kg) divided by the square of your height (in meters) [R].

In general [R]:

People with a BMI between 18.5 and 25 tend to have a healthy weight
People with a BMI between 25 and 30 tend to be overweight
People with a BMI over 30 tend to be obese

People who are overweight or obese are more likely to have [R, R]:

High blood pressure

Type 2 diabetes
Heart disease
Joint problems
Sleep problems

How Maintaining a Healthy Weight Helps Reduce Inflammation

Fat cells may release inflammatory molecules. As obese people have more fat cells,
they produce more of these molecules [R, R].

In line with this, obesity is linked to chronic inflammation in both adults and
children [R, R, R].

Lifestyle and diet changes that support weight loss may reduce inflammation.
Burning as few as 55 more calories per day may help. Adding a 15-minute brisk walk
to your day can help you do this [R, R, R].
 PE RS O NA LI Z E D T O YO UR GE NE S

Maintaining a healthy weight can reduce inflammation by targeting many of

your gene variants at once [R].

Your CRP gene variant is linked to higher inflammation in obese people [R].
Take special care to maintain a healthy weight.

YO UR GE NE T I C VA RI A NT S

GENE SNP G EN OTY PE EVID EN CE

CRP rs1205 CC
 3

Probiotics
I MPA C T E V I DE NC E

4/5 4/5

Probiotic bacteria are “good” bacteria found mainly in the large intestine. They
support your body and mind by [R, R, R, R, R, R, R]:

Maintaining gut health

Supporting a healthy immune system
Improving your mood
Helping to maintain healthy blood sugar

How Probiotics Help Reduce Inflammation

Probiotics may reduce inflammation by supporting “good” gut bacteria. The types of
probiotics studied include [R, R, R, R]:

Lactobacillus casei
L. acidophilus
L. rhamnosus
L. salivarius
Bifidobacterium animalis
B. longum

They may also help when used with prebiotics (food for probiotic bacteria) [R, R, R, R].

Probiotics may also reduce inflammation linked to chronic health conditions [R, R, R, R,
R, R, R].

PE RS O NA LI Z E D T O YO UR GE NE S

Your CRP gene variant is linked to higher levels of CRP, a major

inflammatory protein. Probiotics may help by reducing CRP levels [R, R].

YO UR GE NE T I C VA RI A NT S

GENE SNP G EN OTY PE EVID EN CE

DUSP23 rs7553007 GG
 4

Zinc
I MPA C T E V I DE NC E

3/5 3/5

Zinc is an essential mineral. Your body needs it to [R, R]:

Defend against disease

Protect DNA from damage
Heal wounds
Control blood sugar

Some of the best sources of zinc include shellfish, pork, beef, and beans. It’s also
available as a supplement [R].

How Zinc Helps Reduce Inflammation

Zinc has anti-inflammatory and anti-oxidative effects. Supplementing with zinc (30-40
mg/day) may help reduce inflammation [R, R, R, R].

PE RS O NA LI Z E D T O YO UR GE NE S

Your HNF1A gene variant is linked to higher levels of CRP, a major

inflammatory protein. Zinc may help by reducing CRP levels [R, R].

YO UR GE NE T I C VA RI A NT S

GENE SNP G EN OTY PE EVID EN CE

C12ORF43 rs1183910 GG
 5

Relaxation Techniques
I MPA C T E V I DE NC E

3/5 3/5

We all get stressed from time to time.

Stress can help you deal with a challenge or avoid danger. However, it’s not healthy
to be stressed for a long time [R, R].

Relaxation techniques such as yoga and meditation can relieve stress in different
ways. Most of them focus on breathing and help you get rid of negative thoughts and
emotions [R].

People use relaxation techniques to improve conditions like [R, R, R]:

Anxiety
Depression
Chronic pain

How Relaxation Techniques Help Reduce Inflammation

Stress is linked to chronic inflammation. Causes of stress-related inflammation

include [R, R, R, R, R, R]:

Work-related problems
Relationship problems
PTSD

For some people, relaxation techniques may help. They include [R, R, R]:

Positive engagement coping

Mindfulness
Yoga
Tai chi
Qi gong
 PE RS O NA LI Z E D T O YO UR GE NE S

Stress may have a stronger impact on inflammation in people with your IL6
gene variant [R]. Try to reduce stress by practicing relaxation techniques.

Your CRP gene variant is linked to higher inflammation and stress [R]. Try to
reduce stress by practicing relaxation techniques.

YO UR GE NE T I C VA RI A NT S

GENE SNP G EN OTY PE EVID EN CE

STEAP1B rs1800795 GG

GENE SNP G EN OTY PE EVID EN CE

DUSP23 rs1130864 AA,AG

 6

Avoid Cigarette Smoke

I MPA C T E V I DE NC E

3/5 4/5

You already know that tobacco is not great for your health. Smoking affects your
entire body. It can damage your brain, heart, lungs, and more [R].

And even if you’re not a smoker, secondhand smoke can cause health issues similar
to smoking [R, R].

But, there’s good news: avoiding cigarette smoke can reverse many of its negative
effects. It’s a great way to dramatically improve your health [R].

How Avoiding Cigarette Smoke Helps Reduce Inflammation

Smoking is linked to chronic inflammation. Quitting may help reduce it [R, R, R, R, R,

R, R, R].

Beneficial effects may be seen as early as 1 year after quitting [R, R, R, R].

PE RS O NA LI Z E D T O YO UR GE NE S

Your IL6 gene variant is linked to inflammation in smokers. Quitting

smoking may cancel out the negative effects of this variant [R].

YO UR GE NE T I C VA RI A NT S

GENE SNP G EN OTY PE EVID EN CE

STEAP1B rs2069840 CG,GG

 7

Omega-3 Fatty Acids

I MPA C T E V I DE NC E

3/5 4/5

Omega-3 fatty acids are some of the healthiest fats we can eat. They help lower
inflammation and protect the heart, brain, and eyes. Our bodies produce less
omega-3s than we need for optimal health, so it's important to get enough through
food or supplements [R, R, R].

There are three major types of omega-3s: ALA, EPA, and DHA [R, R].

Fatty fish are rich in EPA and DHA. They include [R]:

Salmon
Tuna
Herring
Sardines

For optimal protection, try to get at least two servings of fatty fish per week. Fish oil
supplements are available for those who don’t eat fish regularly [R].

How Omega-3s Help Reduce Inflammation

Supplementation with omega-3s from fish (1.7-4.2 g/day for 6-24 weeks) may help
reduce low-grade inflammation [R, R, R, R].

Omega-3s may also reduce inflammation linked to chronic health conditions [R, R, R,
R, R, R].

Please note: Fish oil can interact with blood thinners (like aspirin, Plavix, and
Coumadin). Consult your doctor before taking fish oil [R].

PE RS O NA LI Z E D T O YO UR GE NE S

Fish oil supplementation may reduce inflammation in people with your TNF
gene variant [R].

YO UR GE NE T I C VA RI A NT S

GENE SNP G EN OTY PE EVID EN CE

MICB rs1800629 GG
 8

Cinnamon
I MPA C T E V I DE NC E

3/5 3/5

Cinnamon is a spice made from the bark of Cinnamomum trees. It’s mainly used in
cooking and fragrances [R].

As a natural remedy, cinnamon can [R]:

Decrease inflammation
Fight oxidative stress
Kill microbes

There are two main types of cinnamon [R]:

Ceylon or ‘true’ cinnamon (C. verum)

Chinese or Cassia cinnamon (C. cassia)

How Cinnamon Helps Reduce Inflammation

Cinnamon (1.5-3 g/day) may help reduce inflammation. It may be more effective in
people with chronic health conditions [R, R].

Please note: Cassia cinnamon is high in coumarin. This substance may harm the liver
in large amounts. Consult your doctor before using large amounts of Cassia cinnamon
[R, R, R].

PE RS O NA LI Z E D T O YO UR GE NE S

Your CRP gene variant is linked to higher levels of CRP, a major

inflammatory protein. Cinnamon may help by reducing CRP levels [R, R].

YO UR GE NE T I C VA RI A NT S

GENE SNP G EN OTY PE EVID EN CE

DUSP23 rs7553007 GG
 9

Vitamin D
I MPA C T E V I DE NC E

3/5 3/5

Your body needs vitamin D for strong bones. Vitamin D also plays a role in [R]:

Mood
Immunity
Heart health
Blood sugar control

Sunlight is our main source of vitamin D. Experts recommend getting at least 5-15
minutes of midday sun, 2-3 times per week. People with darker skin and those living
at high latitudes may need longer periods of sun exposure [R, R].

Foods like fish, eggs, and fortified milk provide small amounts of vitamin D. People
lacking vitamin D should consider taking a supplement [R].

How Vitamin D Helps Reduce Inflammation

In people over 60, vitamin D deficiency may lead to low-grade inflammation. This may
be especially true in smokers [R].

Vitamin D supplements (1,000-4,000 IU/day for 12-24 weeks) may help reduce
inflammation, but the evidence is mixed [R, R].

They may also help reduce inflammation linked to chronic health conditions [R, R, R,
R, R, R].

Please note: Experts recommend getting 600-800 IU of vitamin D per day. Medical
bodies recommend against taking more than 4,000 IU per day [R].

PE RS O NA LI Z E D T O YO UR GE NE S

Getting more vitamin D may help reduce inflammation in people with your
VDR gene variant [R].

YO UR GE NE T I C VA RI A NT S

GENE SNP G EN OTY PE EVID EN CE

VDR rs2228570 GG
 10

Curcumin
I MPA C T E V I DE NC E

2/5 3/5

Turmeric is a yellow spice from India. It may reduce inflammation and oxidative
stress [R].

The most important active compound in turmeric is curcumin. People use curcumin
for [R, R, R, R, R]:

Joint pain
Hay fever
Mood
High blood sugar
Gut health

How Curcumin Helps Reduce Inflammation

Curcumin (1-2.4 g/day for 4-8 weeks) may reduce inflammation. The effects may be
stronger in people with a higher degree of inflammation. However, some studies
found no benefits [R, R, R].

Note that curcumin is hard to absorb. Look for supplements with bioavailable
curcumin, which is easier to absorb. Combining it with piperine (a compound in black
pepper) may also help [R, R].
Next Steps
Remember, your genes only tell one important part of your health story!
These next steps will teach you how to get the most complete picture of your health.

Your Lifestyle Your Labs Your Supplements

1 Answer questions to understand the
2 Labwork is how you discover the
3 Discover key supplements that you
health impacts of your lifestyle. true impact of your lifestyle and can introduce to your body to
genetics on your current health. achieve optimal health.