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Skin Pathology

This document summarizes different types of skin pathology including inflammatory, benign, malignant, and pre-cancerous conditions. It describes key histological features and notes for several inflammatory dermatopathologies including atopic eczema, lichen sclerosus, chronic plaque psoriasis, drug reactions, and lichen planus. Common benign lesions are also outlined such as cysts, seborrheic keratosis, skin tags, and various melanocytic and non-melanocytic lesions. Finally, it lists different invasive and pre-cancerous malignant conditions of the skin including basal cell carcinoma, squamous cell carcinoma, melanoma, and skin dysplasias located on sun exposed areas or specific

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Sean Keenan
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53 views1 page

Skin Pathology

This document summarizes different types of skin pathology including inflammatory, benign, malignant, and pre-cancerous conditions. It describes key histological features and notes for several inflammatory dermatopathologies including atopic eczema, lichen sclerosus, chronic plaque psoriasis, drug reactions, and lichen planus. Common benign lesions are also outlined such as cysts, seborrheic keratosis, skin tags, and various melanocytic and non-melanocytic lesions. Finally, it lists different invasive and pre-cancerous malignant conditions of the skin including basal cell carcinoma, squamous cell carcinoma, melanoma, and skin dysplasias located on sun exposed areas or specific

Uploaded by

Sean Keenan
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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Skin Pathology

Inflammatory Dermatopathology
Atopic Eczema Lichen Sclerosus
- Hist: Spongiosis; Perivascular inflammation of the - Hist: Hyalinisation/Sclerosis in superficial dermis
superficial dermis; Occasional ↑ eosinophils that are found on genital skin
Chronic Plaque Psoriasis - NB: Associated with Balanitis xerotica obliterans
- Hist: Hyperkeratosis; Epithelial hyperplasia Necrobiotic Granulomatous Inflammation
Drug Reactions - Hist: Histiocytes; Necrotic collagen
- Hist: Numerous eosinophils Fish-Tank Granuloma
Lichen Planus - Hist: Granulomatous inflammation; +Ve ZNS
- Hist: Band-like chronic inflammation along the - NB: M. marinum in hands + arms
Dermal-epidermal junction

Benign Dermatopathology
Non-Melanocytic Lesions
- Cyst: Epidermal inclusion cyst; Pilar (scalp) cyst - Dermatofibroma: Fibrous growth in the dermis
- Seborrheic Keratosis: White-Brown-Black raised area - Ulcer: Open sore; Full loss of epidermis
- Skin Tag: Fibroepithelial polyp - Pyogenic Granuloma: Growth; Usually red
- Squamous Papilloma Hyperpigmented tag; HPV assoc. - Pilonidal Sinus: Small hole/tunnel in skin
Melanocytic Lesions
- Freckle: Small patch of darkened skin - Halo Naevus: Mole surrounded by white ring
- Solar Lentigo: Darkened skin caused by UV exposure - Blue Naevus: Blue mole
- Intradermal Naevus: Classic mole or birthmark - Spitz Naevus: Very similar Hist to melanoma

Malignant Dermatopathology
Invasive Cancer Pre-Cancers
- Epithelial Cancer: BCC; SCC - Squamous Dysplasia: UV; Bowen’s; Actinic Kerat.
- Malignant Melanoma: Melanocytic cancer - Melanocytic: Dysplastic naevus; Melanoma in
- Cutaneous T-cell Lymphoma: Rare type of NHL situ
- Kaposi Sarcoma: HHV8 - Glandular: Paget’s disease of nipple

Skin Dysplasia
Type Location Mild Dysplasia Moderate Dysplasia Severe Dysplasia (in Situ)
Bowen's Disease
Sun Exposure Area Actinic Keratosis Actinic Keratosis
Carcinoma in situ
Squamous
Perineum / Vulva Intraepithelial Neoplasia 1 Intraepithelial Neoplasia 2 Intraepithelial Neoplasia 3
Severely-dysplastic naevus
Moderatly-Dysplastic
Melanocytic Naevus Mildly-Dysplastic Naevus Melanoma in situ
Naevus
Lentigo Maligna
Paget's Disease of the Nipple
Glandular -
Extramammary Paget's Disease

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