Hand Hygiene

9514/GB/01/March 2020 - Hand Sanitizer

Content

1. Hand Sanitizer: definition, regulation

2. Guidelines
3. Ethanol compatibility - Polymers
4. Formulas (Hand Sanitizer)
5. Formulas ( Hand Moisturizing and Soothing)
6. Foaming Agents (Hand wash)

9514/GB/01/March 2020 - Hand Sanitizer 2

Hand Sanitizer
Regulation

9514/GB/01/March 2020 - Hand Sanitizer

Biocidal product regulation: Regulation (EU) No 528/2012

Hand Sanitizer Definition

European biocide directive (REGULATION (EU) No 528/2012 OF THE EUROPEAN PARLIAMENT AND
OF THE COUNCIL of 22 May 2012) defines in annex V Disinfectant products of type 1 as :

“biocidal products used for human hygiene purposes, applied on or in contact with human skin or scalps for
the primary purpose of disinfecting the skin or scalp.”

Non-active substances

art 19 (9) - Where a biocidal product is intended for direct application to the external parts of the human body
(epidermis, hair system, nails, lips and external genital organs), or to the teeth and the mucous membranes of
the oral cavity, it shall not contain any non-active substance that may not be included in a cosmetic product
pursuant to Regulation (EC) No 1223/2009.

9514/GB/01/March 2020 - Hand Sanitizer 4

 ANSM
In the European context, French national health agency ANSM suggests

Ethanol, Isopropanol or propanol (propane-1-ol or n-propanol) at concentrations between 60% - 70% v/v
or a concentration between 520 et 630 mg/g (equivalence obtained by approximation with a mixture of
ethanol and water) and that advises the use of final products that are compliant with NF EN 14476 to
clearly assess Virucidal activity.

9514/GB/01/March 2020 - Hand Sanitizer 5

 French Regulation

JORF Decree 20th March 2020

Source: https://www.legifrance.gouv.fr/eli/arrete/2020/3/20/TREP2008113A/jo/texte

4 exempted formulas for authorization or registration, Environmental Code.

Among these 4 formulas, there are 2 Hand Sanitizers with thickeners.
Formula 1 - Hand Sanitizer with thickener Formula 2 - Hand Sanitizer with thickener

Ingredient Quantity Ingredient Quantity

Ethanol Ethanol
absolute 650 to 750 mL 96° % v/v 58% w/w (~ 65% v/vat 20 °C)
or 96° % V/V 675 to 777 mL or 95° % v/v 59,1% w/w (~ 65% v/v at 20 °C)
or 95° % V/V 681 to 786 mL or 90° % v/v 63,7% w/w (~ 65% v/v at 20 °C)
or 90° %V/V 720 to 830 mL
Glycerin or Propylene glycol or Butylene glycol 0,5 to 5% w/w
Glycerin 50 mL or Propanediol or Diglycerin

Among listed thickeners: 10 à 20 ml Among listed thickeners:

SEPINOV™ EMT 10 SEPIMAX ZEN™ 0.4 to 0.8% w/w
Or SEPINOV™ EMT 10 0.5 to 2% w/w
Water / Aqua Up to 1000,0 mL
Or SIMULGEL™ 600 1 to 4% w/w

Water / Aqua Up to 100%

Thickener: it must be conform with article 19( 9) - UE Regulation n° 528/2012 (see previous slide) w/w: weight / weight v/v: volume/volume

9514/GB/01/March 2020 - Hand Sanitizer 6

 Regulation

Labelling
For information1, labelling must contain the following data:
- Gel name : « Hydroalcoholic Gel for hand hygiene - overridded decree »
- Composition : «Ethanol - Glycerin - used thickener»
- Manufacturer
- Manufacturing date and batch number
- Storage condition
- Several indications:
- Only for skin use
‘ Avoid eye contact
- Keep away from children
1
- Inflammable liquid: keep away from heat Data given for information. It must be checked with the local regulation.

- Instructions for use

Example of guidelines on hand hygiene

9514/GB/01/March 2020 - Hand Sanitizer 7

 Polymer range for
hydroalcoholic gels
- Polymerization Technologies
- Thickening Mechanisms
- Ethanol compatibility

9514/GB/01/March 2020 - Hand Sanitizer

 Polymer Range at a glance
Classic Liquid Polymers Concentrated Liquid Polymer Concentrated Powder Polymers

SIMULGEL™ 600 SEPIGEL™ 305 SEPIPLUS™ 400 SEPINOV™ EMT 10 SEPIMAX™ ZEN
Liquid Liquid Liquid Powder Powder
Acrylamide/
Polyacrylate-13 -
Sodium Acryloyldimethyl Taurate Polyacrylamide - C13-14 Hydroxyethyl Acrylate/Sodium
Polyisobutene - Polysorbate Polyacrylate Crosspolymer-6
Copolymer - Isohexadecane - Isoparaffin - Laureth-7 Acryloyldimethyl Taurate Copolymer
20
Polysorbate 80

Anionic polymers
Pre-neutralized

Polymerization Technology ①: Polymerization Technology ②:

INVERSE LATEX POLYMERIZATION POLYMERIZATION BY PRECIPITATION

Polyelectrolyte Polyelectrolyte with

associative behavior

9514/GB/01/March 2020 - Hand Sanitizer 9

 Thickening Mechanisms
① INVERSE LATEX POLYMERIZATION ② POLYMERIZATION BY PRECIPITATION

SEPIGEL 305™
SIMULGEL™ range SEPIMAX ZEN™
SEPIPLUS™ range

= Hydro-Swelling Droplets (HSD)

Electrostatic repulsions Zoom

Zoom + Hydrophobic interactions
= polyelectrolytes &
associative behavior

SEPINOV™ range

Electrostatic repulsions
= polyelectrolytes

9514/GB/01/March 2020 - Hand Sanitizer 10

 Maximum ethanol incorporated into an aqueous gel

Ethanol compatibility
SIMULGEL™ 600 SEPIGEL™ 305 SEPIPLUS™ 400 SEPINOV™ EMT 10 SEPIMAX™ ZEN
4% 3% 2% 2% 2.8%
Liquid Liquid Liquid Powder Powder
Acrylamide/
Sodium Acryloyldimethyl Taurate Polyacrylamide - C13-14 Isoparaffin Polyacrylate 13 - Polyisobutene - Hydroxyethyl Acrylate/Sodium
Polyacrylate Crosspolymer-6
Copolymer - Isohexadecane - - Laureth-7 Polysorbate 20 Acryloyldimethyl Taurate Copolymer
Polysorbate 80
Ethanol 95°: 62% w/w Ethanol 95°: 70% w/w Ethanol 95°: >65% w/w Ethanol 95°: 65% w/w Ethanol 95°: >95% w/w
68,2% v/v 76,99% v/v 71,49% v/v 71,49% v/v > 96,7% v/v

Turbid Translucent Transparent

Formula: qs polymer for an aqueous gel of 80 000-100 000 mPa.s, x% ethanol 95°, up to 100% Water
Process: prepare the aqueous gel and slowly add the solvent. For the concentrated liquid or powder grades, high shear and /or longer agitation could be necessary.
% v/v given in accordance with equivalence used in JORF “Decree 20th March 2020 : 59,1 % w/w ~ 65 % v/v - Source: https://www.legifrance.gouv.fr/eli/arrete/2020/3/20/TREP2008113A/jo/texte

9514/GB/01/March 2020 - Hand Sanitizer 11

Clarity and Stability with Polymers

66% Alcohol w/w 65% Alcohol w/w 65% Alcohol w/w 65% Alcohol w/w 65% Alcohol w/w
0.8%Sepimax Zen 1.6%Sepinov EMT 1.8%Sepiplus 400 2.2%Sepigel 305 2.2%Simulgel 600
10

9514/GB/01/March 2020 - Hand Sanitizer 12

 2 Approaches

Manufacturing advices
SEPIPLUS™ 400
SEPINOV™ EMT 10 SIMULGEL™ 600
or SEPIMAX ZEN™ SEPIGEL™ 305 Gradual ethanol addition
or Manufacturing equipment:
Liquid grade
SEPIPLUS™ 400
SIMULGEL™ 600
Process 1 SEPIGEL™ 305

Thickening

Water +
Glycerin Gel

SEPINOV™ EMT 10 SEPIPLUS™ 400

Remaining
or SEPIMAX ZEN™ SIMULGEL™ 600 Powder grades
ethanol content
SEPIGEL™ 305 SEPINOV™ EMT 10
or Hydroalcoholic gel SEPIMAX ZEN™
Process 2
Dilution of initial gel
for easier shearing
and polymer dispersion
(powder grades) Thickening

Water +
Glycerin + Gel
Partial Ethanol content (~15%)

9514/GB/01/March 2020 - Hand Sanitizer 13

 Formulas

9514/GB/01/March 2020 - Hand Sanitizer

 AS40067A I TEXTURIZED HAND SANITIZER
HYGIENE

A Aqua/Water Up to 100%
Glycerin 3.00% This gel disinfects hands while
Absolute Ethanol (99,7°)* 66.00% moisturizing them.
B SEPIMAX ZEN™ 0.80% SEPIMAX™ ZEN (Polyacrylate Crosspolymer-6)
io ed C AQUAXYL™ 1.00% Pre-neutralized powder polymeric thickener with a MAXIMUM
at ix
n) 3 resistance to electrolytes thanks to its high associative behavior.
nt (f

Efficient on a wide range of pH from 3 to 8, it is able to formulate

ie E

transparent aqueous gels.

or R

SEPIMAX ZEN™ allows to thicken and texturize gels with high dosage
& TU

of alcohol, ideal for hand sanitizer. It also imparts rich, velvet and elegant
at IC

skin feel.
rm P
fo UR

AQUAXYL™ (Xylitylglucoside and Anhydroxylitol and Xylitol)

moisturizes and restructures the skin by harmonizing the hydric flow of
YO

the skin. Water reserves are instantly boosted, water circulation is

improved in all skin layers and water loss is reduced (in vitro and in vivo
tests prove this efficacy).
©UNSPLASH

* In our formula, % ethanol is given in %w/w. It corresponds with 74,4% v/v

Clear Gel / Packaging: Pump Conformity with standard NF EN 14476 is not verified.
pH: 6.5 / VISCOSITIES: M1 at RT: 8 900 mPa.s Brookfield LV2-6 /
Recovery at RT (after 1M at 45°C): 8 700 mPa.s Brookfield LV2-6.
STABILITY: M1 at RT, 45°C, cycles -5°C/+40°C.
Hand sanitizer
FORMULATION ADVICES / Weigh the phase A and phase B. Disperse
phase B to phase A and stir at 800 ~ 1000 rpm with deflocculator for
Moisturizing 30 minutes or until uniform. Add phase C to phase A+B, stir with
anchor at 150 rpm for 10 minutes. Use rotor-stator homogenizer to
make a homogeneous gel if necessary. ADDITIONAL INGREDIENTS: Glycerine - PRICERINE 9091 (KARRY) / Alcohol - ALCOHOL (96%) (ANTE)

COLD
More informations available on seppic.com
PROCESS

All information contained herein is intended merely to demonstrate the utility of SEPPIC products, and should not be construed as granting license to practice any compositions or methods covered by a patent or a A company
9514/GB/01/March 2020 - Hand Sanitizer
patent application. All information contained in this specific technical documentation is believed to be accurate and has been set up by SEPPIC according to its own described methods and processes. SEPPIC however
does not assume any liability or risks involved in the use of its products for the preparation and the assessment of the hereinabove formulation since the condition of use are beyond its control. SEPPIC customer must 15
insure that the duplication of the hereinabove formulation is not infringing any intellectual property rights and that it complies with any regulatory status.
 EU07037A I BLUE HYDROALCOHOLIC GEL
Clean hands easily
HYGIENE

Minimalist Gel Sanitizer

Gel texture for easy handling
A Aqua/Water Qs 100%
Ethanol 96°* 65,00%
Colorant qs
Liquid polymer resistant to electrolytes and with good compatibility with
B SEPIPLUS™ 400 2,25% solvents such as ethanol, SEPIPLUS™ 400 (Polyacrylate-1-3 - Polyisobutene -
Polysorbate 20), allows the formulation of minimalist gels. It is also possible to
formulate hydroalcoholic gel without mixer.

It is possible to add 3-5% glycerin to limit skin dehydration.

* In our formula, % ethanol is given in %w/w

Theoretical calculation of ethanol in our formula: 72,84% v/v (in accordance
with equivalence used in JORF “Decree 20th March 2020)
Source: https://www.legifrance.gouv.fr/eli/arrete/2020/3/20/TREP2008113A/jo/texte
©ADOBESTOCK

Conformity with standard NF EN 14476 is not verified.

Opaque blue gel / Challenge test: Criteria A / Packaging: Pump

pH: 6.5 / VISCOSITIES: 1M at RT: 46,000 mPa.s Brookfield S4S6 /
STABILITY: 1M at RT.

Clean Hands
FORMULATION ADVICES: Pilot- 2k g - DUMEK
Introduce water into the main tank, add ethanol and the blue dye, mix.
Sanitizer Add SEPIPLUS™ 400 then mix under vacuum with rotor/stator for 10’.
ADDITIONAL INGREDIENTS :Colorant FDC Blue n°1 (LCW).

COLD
PROCESS More informations available on seppic.com

All information contained herein is intended merely to demonstrate the utility of SEPPIC products, and should not be construed as granting license to practice any compositions or methods covered by a patent or a A company
9514/GB/01/March 2020 - Hand Sanitizer
patent application. All information contained in this specific technical documentation is believed to be accurate and has been set up by SEPPIC according to its own described methods and processes. SEPPIC however
does not assume any liability or risks involved in the use of its products for the preparation and the assessment of the hereinabove formulation since the condition of use are beyond its control. SEPPIC customer must 16
insure that the duplication of the hereinabove formulation is not infringing any intellectual property rights and that it complies with any regulatory status.
 EU07613 I TRANSLUCID HYDROALCOHOLIC GEL
HYGIENE

A simple sanitizing formula for hands

A Aqua/Water QSP 100%
Its gel texture makes handling easier
Ethanol 95°* 65.00%
SEPINOV™ EMT 10 1.50%
With a good solvent compatibility, SEPINOV™ EMT 10 (Hydroxyethyl
Acrylate/ Sodium Acryloyldimethyl Taurate Copolymer) allows the formulation of
hydroalcoholic gel with a high alcohol content and a clear aspect.

It is possible to add 3-5% glycerin to limit skin dehydration.

* In our formula, % ethanol is given in %w/w

Theoretical calculation of ethanol in our formula: 68,27% v/v (in accordance
with equivalence used in JORF “Decree 20th March 2020)
Source: https://www.legifrance.gouv.fr/eli/arrete/2020/3/20/TREP2008113A/jo/texte
©ADOBESTOCK

Conformity with standard NF EN 14476 is not verified.

Translucid Gel / Packaging : Tube

pH: 5.0 / VISCOSITIES : 14,000 mPa.s Brookfield LV 3-6

Translucid gel
FORMULATION ADVICES - Laboratory scale - 300 g
Mix SEPINOV ™ EMT 10 with water in a beaker. Add alcohol step
by step.
Sanitizer
More informations available on seppic.com
COLD
PROCESS

All information contained herein is intended merely to demonstrate the utility of SEPPIC products, and should not be construed as granting license to practice any compositions or methods covered by a patent or a A company
9514/GB/01/March 2020 - Hand Sanitizer
patent application. All information contained in this specific technical documentation is believed to be accurate and has been set up by SEPPIC according to its own described methods and processes. SEPPIC however
does not assume any liability or risks involved in the use of its products for the preparation and the assessment of the hereinabove formulation since the condition of use are beyond its control. SEPPIC customer must 17
insure that the duplication of the hereinabove formulation is not infringing any intellectual property rights and that it complies with any regulatory status.
 EU07614I SPRAYABLE HYDROALCOHOLIC GEL
HYGIENE

New hand spray sanitizer

A Aqua/Water QSP 100%
A new gesture !
B SEPINOV™ EMT 10 0.80%
SEPINOV™ EMT 10 (Hydroxyethyl Acrylate/ Sodium Acryloyldimethyl Taurate
C Ethanol 95°* 65.00% Copolymer) is compatible with solvents. It stabilizes this gel containing a high
alcohol content and allows the obtention of a translucent liquid.
It can also creates also easily sprayable textures, like this spray, for an easily
and homogeneous application.

It is possible to add 3-5% glycerin to limit skin dehydration.

* In our formula, % ethanol is given in %w/w

Theoretical calculation of ethanol in our formula: 71,49% v/v (in accordance
with equivalence used in JORF “Decree 20th March 2020))
Source: https://www.legifrance.gouv.fr/eli/arrete/2020/3/20/TREP2008113A/jo/texte
©ADOBESTOCK

Conformity with standard NF EN 14476 is not verified.

Clear Liquid Packaging : Spray

Sanitizer pH: 5.80 / VISCOSITIES : 5 800 mPa.s Brookfield LV 3-6

FORMULATION ADVICES - Laboratory scale - 300 g

Sprayable Under deflocculating stirrer, mix SEPINOV™ EMT 10 with water.
Add alcohol step by step.
More informations available on seppic.com
COLD
PROCESS

All information contained herein is intended merely to demonstrate the utility of SEPPIC products, and should not be construed as granting license to practice any compositions or methods covered by a patent or a A company
9514/GB/01/March 2020 - Hand Sanitizer
patent application. All information contained in this specific technical documentation is believed to be accurate and has been set up by SEPPIC according to its own described methods and processes. SEPPIC however
does not assume any liability or risks involved in the use of its products for the preparation and the assessment of the hereinabove formulation since the condition of use are beyond its control. SEPPIC customer must 18
insure that the duplication of the hereinabove formulation is not infringing any intellectual property rights and that it complies with any regulatory status.
 EU07612I THICK HYDROALCOHOLIC GEL
HYGIENE

Thick Hydroalcoholic Gel

A Aqua/Water QS 100%
A thick gel texture for an easier application
Ethanol 95°* 60.00%
B SIMULGEL™ 600 4.00% Liquid polymer, SIMULGEL™ 600 (Acrylamide/Sodium Acryloydimethyl Taurate &
Isohexadecane & Polysorbate 80), stabilizes this gel with a high alcohol content
thanks to its good compatibility with solvents.

It is possible to add 3-5% glycerin to limit skin dehydration.

* In our formula, % ethanol is given in %w/w

Theoretical calculation of ethanol in our formula: 65,99% v/v (in accordance
with equivalence used in JORF “Decree 20th March 2020)
Source: https://www.legifrance.gouv.fr/eli/arrete/2020/3/20/TREP2008113A/jo/texte
©ADOBESTOCK

Conformity with standard NF EN 14476 is not verified.

Turbid Gel/ Packaging : tube

Protective gel pH: 6.0 / VISCOSITIES :85 000 mPa.s Brookfield LV 4-6
STABILITÉ: 1M at RT.

FORMULATION ADVICES - Laboratory scale - 300 g

Cleanser Mix water and 95° alcohol, add SIMULGEL™ 600. Homogenize
using a rotor-stator.
More informations available on seppic.com
COLD
PROCESS

All information contained herein is intended merely to demonstrate the utility of SEPPIC products, and should not be construed as granting license to practice any compositions or methods covered by a patent or a A company
9514/GB/01/March 2020 - Hand Sanitizer
patent application. All information contained in this specific technical documentation is believed to be accurate and has been set up by SEPPIC according to its own described methods and processes. SEPPIC however
does not assume any liability or risks involved in the use of its products for the preparation and the assessment of the hereinabove formulation since the condition of use are beyond its control. SEPPIC customer must 19
insure that the duplication of the hereinabove formulation is not infringing any intellectual property rights and that it complies with any regulatory status.
 EU06371A I HYDROALCOHOLIC GEL
HYGIENE

Minimalist Sanitizer
Gel texture for easy handling
A Aqua/Water Qs 100%
Ethanol 90°* 67,00%
B SEPIGEL™ 305 3,00% Liquid polymer, easy to use, with good compatibility with solvents such
as ethanol, SEPIGEL™ 305 (Polyacrylamide - C13-14 Isoparaffin - Laureth-7) allows
the formulation of minimalist gels. It has a creamy feel and produces very
easily gels with a soft texture.

It is possible to add 3-5% glycerin to limit skin dehydration.

* In our formula, % ethanol is given in %w/w

Theoretical calculation of ethanol in our formula: 68,37% v/v (in accordance
with equivalence used in JORF “Decree 20th March 2020))
Source: https://www.legifrance.gouv.fr/eli/arrete/2020/3/20/TREP2008113A/jo/texte
©ADOBESTOCK

Conformity with standard NF EN 14476 is not verified.

Turbid gel / Packaging: Pump

VISCOSITIES: 1M at RT: 35,000 mPa.s Brookfield S4S6/
Sanitizer STABILITY: 1M at RT.

FORMULATION ADVICES: Pilot- 2k g - DUMEK

Progressively add A into B while stirring.

COLD
PROCESS More informations available on seppic.com

All information contained herein is intended merely to demonstrate the utility of SEPPIC products, and should not be construed as granting license to practice any compositions or methods covered by a patent or a A company
9514/GB/01/March 2020 - Hand Sanitizer
patent application. All information contained in this specific technical documentation is believed to be accurate and has been set up by SEPPIC according to its own described methods and processes. SEPPIC however
does not assume any liability or risks involved in the use of its products for the preparation and the assessment of the hereinabove formulation since the condition of use are beyond its control. SEPPIC customer must 20
insure that the duplication of the hereinabove formulation is not infringing any intellectual property rights and that it complies with any regulatory status.
 Concern Due to Excess
Sanitization

- Too Harsh Cleanser

- Uncomfortable Hand feeling
- Dry Skin
- Redness

9514/GB/01/March 2020 - Hand Sanitizer

Hand Nourishing
Moisturizing and Soothing

9514/GB/01/March 2020 - Hand Sanitizer

Emulsifier range

- Montanov Liquid Crystal

- Moisturization
- Stable cream

9514/GB/01/March 2020 - Hand Sanitizer

MONTANOV™ range
Liquid Crystals & Long-lasting Moisturization
ACTIVE-EMULSIFIERS, through liquid crystal promotion !
A dual organization… for twice the effectiveness !
Lamellar phases
Lamellar bilayers in the continuous aqueous phase
around the oil droplets (hydrogen-fatty acid-alcohol bonds)

Water
Oil

Water
Optical microscope
Electronic
x400
microscope after
polarized light
cryofracture

Effect n°1- Promotes emulsion stability

Rigid shells around oil droplets Elastic network in the external phase
⬇ prevents coalescence ⬇ suspension ability, viscosity

9514/GB/01/March 2020 - Hand Sanitizer 24

 MONTANOV™ range Formula
Liquid crystals & Long-lasting moisturization Emulsifier
LANOL™ 99
5%
20%

SIMULGEL™ EG 0.5%
Dominant elastic network Up to
Preservative
(rheometer measurement with oscillation protocol)
Aqua/Water Up to 100%

MONTANOV™ 202
G’: elastic modulus G’’: viscous modulus
forms
the best dominant
Viscosity D7 25000 mPa.s 25000 mPa.s 35000 mPa.s 4000 mPa.s 300 mPa.s
elastic network 25
Stability RT Stable M6 Stable M6 Stable M6 Separation D7 Stable M6
in comparison to the other
Stability 40°C Stable M6 Stable M6 Stable M6 Separation D1 Separation M2
tested emulsifiers!
Stability 50°C Stable M1 Stable M1 Separation D7 Separation D1 Separation D7

9514/GB/01/March 2020 - Hand Sanitizer

MONTANOV™ range
Liquid Crystals & Long-lasting Moisturization

Effect n°2- Strengthens the lipid barrier

Similar organization of lamellar phases to epidermis lipids for excellent skin affinity
⬇ Restructuring effect (In Vitro)

l 2 +++
Protocole
ge 14 S 82 68 L 20
am ™ ™ ™ ™ V™ V™ Drying • In Vitro test
re
NO
V
OV OV OV NO NO
lc AN AN AN
tro NT
A
NT NT TA TA effect • Gelatine cells
n NT N N
Co MO MO MO MO MO MO • SEPPIC method 57 CO 010
MONTANOV™
L
+++ Formula
Structuring
EMULSIFIER 5%
effect
LANOL™ 99 20%
Limit skin
dehydration SIMULGEL™ EG 0.5%

Preservative qs 26
Aqua/Water Up to 100%

9514/GB/01/March 2020 - Hand Sanitizer

MONTANOV™ range
Liquid Crystals & Long-lasting Moisturization
Effect n°3 - Moisturization - Immediate effect
Water reservoirs for gradual release
⬇ Moisturizing effect for up to 5 hours after application (In Vivo)

* Protocole Formula

* * • In Vivo test
EMULSIFIER 3%
* * • 20 volunteers with dry skin (<50 a.u.) LANOL™ 1688 20%
• Single application
SIMULGEL™ EG 0.5%
• Application zone: leg
* * * * • Corneometer CM 825 Preservative qs
** * * 27
* * Aqua/Water Up to 100%

Control MONTANOV™ MONTANOV™ MONTANOV™ MONTANOV™ MONTANOV™

cream gel 68 202 L 82 S
* Significant results (p<0.05) compared to non treated zone

9514/GB/01/March 2020 - Hand Sanitizer

MONTANOV™ range
Liquid Crystals & Long-lasting Moisturization
Effect n°3- Moisturization – Long lasting effect

DOUBLE MOISTURIZATION by combining MONTANOV™ L + AQUAXYL™

Protocole
⬇ Prolonged moisturizing effect for up to 48hrs after application (In Vivo)

EXTREME CONDITIONS
• In Vivo test
• 50 volunteers with very dry skin (<30 a.u.)
• Single application
• Application zone: leg
• Corneometer CM 825

Formula
* 1min
MONTANOV™ L 3%
* application LANOL™ 2681 5%

* Sweet Almond Oil 8%

48hrs Dicaprylyl Carbonate 2%
* hydration! SOLAGUM™ AX 1.5%
Dehydroacetic Acid and 0.8%
Benzyl Alcohol
Dehydroacetic Acid 0.2%
3% MONTANOV™ L 3% MONTANOV™ L
AQUAXYL™ 3%
+ 3% AQUAXYL™
Aqua/Water Up to 100%
* * Highly significant results (p<0.01) compared to the control cream gel

9514/GB/01/March 2020 - Hand Sanitizer 28

HYGIENE

All information contained herein is intended merely to demonstrate the utility of SEPPIC products, and should not be construed as granting license to practice any compositions or methods covered by a patent or a A company
9514/GB/01/March 2020 - Hand Sanitizer
patent application. All information contained in this specific technical documentation is believed to be accurate and has been set up by SEPPIC according to its own described methods and processes. SEPPIC however
does not assume any liability or risks involved in the use of its products for the preparation and the assessment of the hereinabove formulation since the condition of use are beyond its control. SEPPIC customer must 29
insure that the duplication of the hereinabove formulation is not infringing any intellectual property rights and that it complies with any regulatory status.
HYGIENE

All information contained herein is intended merely to demonstrate the utility of SEPPIC products, and should not be construed as granting license to practice any compositions or methods covered by a patent or a A company
9514/GB/01/March 2020 - Hand Sanitizer
patent application. All information contained in this specific technical documentation is believed to be accurate and has been set up by SEPPIC according to its own described methods and processes. SEPPIC however
does not assume any liability or risks involved in the use of its products for the preparation and the assessment of the hereinabove formulation since the condition of use are beyond its control. SEPPIC customer must 30
insure that the duplication of the hereinabove formulation is not infringing any intellectual property rights and that it complies with any regulatory status.
HYGIENE

All information contained herein is intended merely to demonstrate the utility of SEPPIC products, and should not be construed as granting license to practice any compositions or methods covered by a patent or a A company
9514/GB/01/March 2020 - Hand Sanitizer
patent application. All information contained in this specific technical documentation is believed to be accurate and has been set up by SEPPIC according to its own described methods and processes. SEPPIC however
does not assume any liability or risks involved in the use of its products for the preparation and the assessment of the hereinabove formulation since the condition of use are beyond its control. SEPPIC customer must 31
insure that the duplication of the hereinabove formulation is not infringing any intellectual property rights and that it complies with any regulatory status.
 Hand Wash -
Foaming Range

9514/GB/01/March 2020 - Hand Sanitizer

 Foaming range
SKIN COMFORT WITH FOAM MILDNESS

9514/GB/01/March 2020 - Hand Sanitizer

The foaming range at a glance
Choose your foam
AMONYL™ 675 SB
PROTEOL™ APL EF ORONAL™ LCG/E OD
A little extra help
One of the most Ideal for the most
for a mild foam
gentle beauty PROTEOL™ OAT PF sensitive & delicate
experiences A cleansing but non skin skins
drying-out lather

ORAMIX™ CG110 ORAMIX™ NS10

Cleanser & solubilizer ORAMIX™ L30
A naturally abundant
bringing a green touch to Skin & hair gentle cleanser,34
foam!
all formulas superior foaming ability
compared to SLES

9514/GB/01/March 2020 - Hand Sanitizer

HYGIENE

All information contained herein is intended merely to demonstrate the utility of SEPPIC products, and should not be construed as granting license to practice any compositions or methods covered by a patent or a A company
9514/GB/01/March 2020 - Hand Sanitizer
patent application. All information contained in this specific technical documentation is believed to be accurate and has been set up by SEPPIC according to its own described methods and processes. SEPPIC however
does not assume any liability or risks involved in the use of its products for the preparation and the assessment of the hereinabove formulation since the condition of use are beyond its control. SEPPIC customer must 35
insure that the duplication of the hereinabove formulation is not infringing any intellectual property rights and that it complies with any regulatory status.
HYGIENE

All information contained herein is intended merely to demonstrate the utility of SEPPIC products, and should not be construed as granting license to practice any compositions or methods covered by a patent or a A company
9514/GB/01/March 2020 - Hand Sanitizer
patent application. All information contained in this specific technical documentation is believed to be accurate and has been set up by SEPPIC according to its own described methods and processes. SEPPIC however
does not assume any liability or risks involved in the use of its products for the preparation and the assessment of the hereinabove formulation since the condition of use are beyond its control. SEPPIC customer must 36
insure that the duplication of the hereinabove formulation is not infringing any intellectual property rights and that it complies with any regulatory status.
Thank you !

A company of

9514/GB/01/March 2020 - Hand Sanitizer 37