BIOL/BBB251: Course Syllabus FALL 2014
CELLULAR and MOLECULAR NEUROBIOLOGY
BIOLOGY/BIBB 251
COURSE SYLLABUS (REVISED)
FALL 2014
Lectures: Monday, Wednesday, 2:00-3:30
Room LEIDY 10
Instructors:
(MFS) Marc Schmidt (course director), 312 Leidy Labs/6018, 898-9375, marcschm@sas.upenn.edu
(MK) Mike Kaplan, Neurolab (Leidy Labs), 573-2654 mkap@sas.upenn.edu
(TEA) Ted Abel, 10-133 Translational Research Center, 746-1122, abele@sas.upenn.edu
Teaching Assistants
Chris Angelakos can@mail.med.upenn.edu
Janani Saikamar sjanani@sas.upenn.edu
Brendan Whitelaw brwhit@sas.upenn.edu
Nick Trojanowski ntroj@mail.med.upenn.edu
Lindsey Goodman lindsey@goodman.net
Yunshu Fan yunshuf@mail.med.upenn.edu
Required text: Nicholls, Martin, Wallace, and Fuchs: From Neuron to Brain, 5th Edn., Sinauer, 2012 (ISBN 978-0-87893-609-0).
Lecture notes, slides and other materials available on the class website (canvas.upenn.edu)
lecture date topic lecturer readings
1 W Aug 27 Introduction MFS TA-MK-MFS chapter 1
Part 1: Ion channels and the membrane potential
2 W Sept 3 Membrane currents and the resting potential MK Ch. 6
3 M Sept 8 Action potential: macroscopic currents, Hodgkin & Huxley MK Ch. 7
4 W Sept 10 Action potential: patch clamp and single channel currents MK Ch. 4
5 M Sept 15 Molecular biology of ligand-gated ion channels 1 TEA Ch. 5
6 W Sept 17 Molecular biology of ligand-gated ion channels 2 TEA Ch. 5
7 M Sept 22 Cable properties MFS Ch. 8
W Sept 24 REVIEW MK, TA, MFS
M Sept 29 EXAM 1 (lectures 1-7)
Part 2: Synapses and synaptic plasticity
8 W Oct 1 Synapses 1: Four facts about neurotransmission MK Ch 11, 13; end of Ch. 8 (139-140)
9 M Oct 6 Synapses 2: Presynaptic mechanisms MK Ch. 11, 13, and 15
10 W Oct 8 Synapses 3: ionotropic transmission MK, TA Ch. 12
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BIOL/BBB251: Course Syllabus FALL 2014
11 M Oct 13 Synapses 4: metabotropic mechanisms MK Ch. 12
12 W Oct 15 Synaptic plasticity 1: Aplysia TA Carew chapter 10; Kandel 2001
13 M Oct 20 Synaptic plasticity 2: Drosophila TA Carew chapter 11
14 W Oct 22 Synaptic plasticity 3: LTP TA Ch. 16
15 M Oct 27 Synaptic plasticity 4: LTP and genetics TA Ch. 16, Abel 1997
16 W Oct 29 Integration and dendritic physiology MFS Ch. 8 (137-141); Ch. 24 (498-501);
Paper: Magee et al. (2000).
M Nov 3 EXAM 2 (Lectures 8-16)
Part 3: Cell and molecular systems neuroscience
17 W Nov 5 Olfaction: molecular maps TA Purves, Ch. 15
18 M Nov 10 Olfaction neural mechanisms MFS Purves, Ch. 15; Smear et al. 2011
19 W Nov 12 Guest lecture: Michela Gallagher*
*(This program is made possible by a grant from the Fund to Encourage Women (FEW) of the Trustees of Penn Women)
20 M Nov 17 Ion channel diversity and electrical diversity MK Nusbaum and Beenhacker 2002
21 W Nov 19 Glia MFS Ch. 9 (151-157); Ch.10;
Ch 15 (305-306)
22 M Nov 24 Information processing in the retina 1 MFS Ch. 2 (26-29); Ch. 20 (407-431)
W Nov 26 NO CLASS
Nov 27 Thanksgiving break (Nov. 27-30)
23 M Dec 1 Information processing in the retina 2 MFS Ch. 20 (407-431)
24 W Dec 3 Auditory system 1 MFS Ch. 19 (392-396);
25 M Dec 8 Auditory system 2 MFS Ch. 22 (453-467)
Dec 16 FINAL EXAM 6-8 p.m. location T.B.A.
REVIEW SESSIONS
EXAM 1 (Sept. 29)
Wednesday, Sept. 25 FACULTY REVIEW 2-3:30 LEIDY 10
Friday, Sept 28 TA-led REVIEW 5-6:30 GODDARD 101
EXAM 2 (Nov. 3)
Thursday, Oct. 30 TA-led REVIEW 4:30-6:00 LEIDY 10
Friday, Oct. 31 FACULTY REVIEW 3-5:00 LEIDY 10
FINAL EXAM (Dec. 16): TBA
OFFICE HOURS
Instructors: Time: Location:
Ted Abel T.B.A. 204G Lynch Labs
Mike Kaplan Wednesdays 11:30-1:30 Neurolab, Leidy Labs
Marc Schmidt T.B.A. 312 Leidy Labs
Syllabus: Page 2 of 3
10/20/2014
BIOL/BBB251: Course Syllabus FALL 2014
ADDITIONAL READINGS
Abel,
T.,
Nguyen,
P.V.,
Barad,
M.,
Deuel,
T.A.,
Kandel,
E.R.,
and
Bourtchouladze,
R.
(1997).
Genetic
demonstration
of
a
role
for
PKA
in
the
late
phase
of
LTP
and
in
hippocampus-‐based
long-‐term
memory.
Cell
88,
615-‐626.
Fatt,
P.,
and
Katz,
B.
(1952).
Spontaneous
subthreshold
activity
at
motor
nerve
endings.
J
Physiol
117,
109-‐128.
Kandel,
E.R.
(2001).
The
molecular
biology
of
memory
storage:
a
dialogue
between
genes
and
synapses.
Science
294,
1030-‐
1038.
Magee
J.
C.
(2000)
Dendritic
Integration
of
excitatory
synaptic
input
Nature
Reviews
Neuroscience
1:
181
-‐
190
Mombaerts,
P.,
Wang,
F.,
Dulac,
C.,
Chao,
S.K.,
Nemes,
A.,
Mendelsohn,
M.,
Edmondson,
J.,
and
Axel,
R.
(1996).
Visualizing
an
olfactory
sensory
map.
Cell
87,
675-‐686.
Nusbaum MP, Beenhakker MP (2002) A small-systems approach to motor pattern generation. Nature 417:343-350.
Smear
et
al.
(2011)
Perception
in
sniff
phase
in
mouse
olfaction
Nature
479:
397
-‐
400
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10/20/2014
