FOR THE USE ONLY OF A VETERINARIAN OR 373102 R1
A HOSPITAL OR A LABORATORY OR A FARM
Rabies Vaccine (Cell
cultured, Inactivated)
Nobivac® RABIES
NOT FOR HUMAN USE – FOR ANIMAL TREATMENT ONLY
WARNING : To be sold by retail on the prescription of a Registered
Veterinary Practitioner only.
DESCRIPTION
This vaccine contains an inactivated culture of Rabies virus, cloned out of strain Pasteur
RIVM with a potency ≥2 I.U. The virus is grown on the BHK-21 clone CT cell line and
inactivated with beta – propiolactone. It is presented as an aqueous Aluminium phosphate
suspension. Colour of the vaccine may vary from light yellow/ orange to slightly red/
purple with a whitish sediment. Thiomersal is used as preservative.
COMPOSITION
Each 1 ml dose contains : Inactivated Rabies strain Pasteur RIVM with potency ≥ 2 I.U.
Preservative : Thiomersal 0.01% w/v
INDICATION
For the active immunisation of healthy dogs, cats, cattle, sheep, goats, ferrets, foxes and
horses (and in principle all healthy mammals) against Rabies. Nobivac Rabies can be used
for both prophylactic (pre-exposure) immunisation and for post-bite treatment (post –
exposure prophylaxis).
NB-Post-bite treatment (post –exposure prophylaxis) should not be used as an alternative,
to avoid vaccinating animals prophylactically (pre-exposure). It is recommended that all
animals at risk of exposure are vaccinated prophylactically. Post-bite treatment (post –
exposure prophylaxis) should be carried out under strict supervision of a registered
veterinary practitioner only.
VACCINATION SCHEME – PROPHYLAXIS (PRE-EXPOSURE)
Dogs/Cats Cattle/Horses Ferrets
Sheep/Goats
Primary vaccination at 3 months * 6 months* 3 months *
an age of more than
Revaccination every 3 years ** 2 years** 1 year **
Route of administration IM or SC IM SC
* Primary vaccination can be administered at an earlier age, but then a repeat
vaccination must be given at the age of 3 or 6 months depending on the species.
** Recommended revaccination interval is based upon results from challenge experiments.
Local regulations in force may require earlier revaccination
Results from serological investigations indicate that vaccination of sheep, goats and foxes
provides protection for at least one year.
VACCINATION SCHEME – POST-BITE TREATMENT (POST-EXPOSURE
PROPHYLAXIS)
In all species, repeated single doses of vaccine should be administered (by the above
recommended route) according to the following schedule.
PSC020502 02 R1
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Dose no. Timing
1st Day 0 (as soon as possible following bite/exposure)
2nd Day 3
3rd Day 7
4th Day 14
5th Day 28
IMPORTANT: Vaccination leads to a high peak of antibody levels within 3
weeks. Whilst post-bite treatment (post exposure prophylaxis) will, if
administered promptly, protect the majority of exposed animals from developing
Rabies, as with any post infection treatment, it remains possible that disease may
still occur in individual cases. It is therefore vitally important that owners are
informed about this and that they are advised to monitor their animal closely for
any signs of disease for the remainder of the incubation period. Should any
suspicious signs appear, the animal should be treated as potentially rabid, and
immediate veterinary advice should be sought.
DOSAGE AND ADMINISTRATION
1 ml subcutaneous or intramuscular injection.
• Shake well before use.
• Allow the vaccine to reach ambient temperature (15 to 25°C)
• Use sterile needle and syringe.
Note - Nobivac Rabies can be used to reconstitute the freeze-dried Nobivac canine vaccines
and can be administered in combination with Nobivac Lepto.
For 10 dose presentation, broached vials should be used within one working day.
VACCINATION REACTIONS
After subcutaneous administration occasionally a transient palpable nodule may occur at
the site of injection.
Generalised hypersensitivity reactions following administration may occasionally occur. In
this event administration of Adrenaline injection by the subcutaneous route may be indicated.
IMMUNITY
In dogs, peak antibody titres have been demonstrated to occur by 3 weeks after
vaccination.
WITHDRAWAL PERIOD
None.
SHELF LIFE: At least 4 years at 2 to 8 ⁰C
STORAGE CONDITIONS
Store in dark between 2°C to 8°C.
Avoid freezing.
PRESENTATIONS
Single dose vials and multidose vials of 10 doses.
®Registered Trademark
Imported and Marketed by:
Intervet India Pvt. Ltd.
Sagar complex, Bldg.B-1
Gala No. 12 to 16
Ovali Village, Bhiwandi
Thane 421302
Manufactured by: Intervet International BV
Wim de Körverstraat 35,
5831 AN
Boxmeer, The Netherlands
PSC020502 02 R1
90 x 160 mm
Black
Moved to repository by COPPUS 02:Dec:2020 11:04
