Heamopoiesis
Stages of
development of By
RBCs, WBCs, and Lasika chaudhari
platelets. 1st prof. BAMS student
Dept of kriya shaarir
Guided by :Dr. Mukhta ma’am
Contents
• Definition
• Introduction to blood
• RBC
• Formation of RBC
• WBC
• Formation of WBC
• Platelets
• Formation of platelets
•
Defination
• Heamo- blood
• Poiesis- formation or development
• Heamopoiesis is the process of origin, development and maturation of
the Blood cell.
•
Blood
• Blood is the red colour fluid that circulates through vascular
system in humans and other vertebrates.
• Its carries nutrients and oxygen to the parts of body.
• And also waste products like carbon dioxide from all the parts of the body.
• Contains:- 1.RBCs (erythrocytes)
2.WBCs ( Leukocytes )
3.platelets(thrombocytes)
4.plasma
5.serum
RBC (erythrocytes)
• The non nucleated formed elements in the blood.
• Blood got its red colour due to presence of these cells.
• These are red due to Presence of colouring pigment Haemoglobin
• Plays role in transportation of respiratory gases.
• Normal value : males=5 millions /mm^3
Females=4.5 millions /mm^3
Erythropoiesis
Definition
Erythropoiesis is the process of origin, develpoment, and maturation of rbc.
• It includes different stages of development of the cell, from its origin upto
maturation.
Site of erythropoiesis
In Fetal life After birth
In fetal life it occurs in 3 stages Up to 20 yrs
Red bone marrow Nearly in all type of
1. Mesoblastic stage bones.
During first 2 months yolk sac
2. Hepatic stage In adults
From third month liver Red bone marrow membranous bones
(vertebrae, sternum, ribs iliac bones etc.)
3. Myeloid stage
During last 3 months bone marrow
1.Proerythroblast
2.Early normoblast
3.Intermediate normoblast
4. Late normoblast
5.Reticulocyte
6. Matured erythrocyte
RBCs
development of
Stages of
1. Proerythroblast (megaloblast)
First cell drrived from CFU-E
Very large in size.
Nucleus is large with two or more reticular network.
Does not contain hemoglobin.
2. Early normoblast (basophilic erythroblast)
Becomes little smaller
In nucleus, nucleoli disappers.
Condensation of cromatin network occurs.
3. Intermediate normoblast (Polychromatic erythroblast)
Further reduction in size.
Nucleus is still present.
Heamoglobin starts to appear.
4. Late normoblast (Orthochromatic erythroblast)
Further more decrease in size.
Nucleus becomes very small and very much condensed chromatin network.
Quantity of heamoglobin increases.
5. Reticulocyte (immature RBC)
slightly larger than matured RBC.
Cytoplasm contains reticular network.
Cell enters the capillary from the site of production.
Nucleus gets disappear.
6. Matured RBC
Reticular network disappears.
Becomes mature.
Attains the biconcave shape.
Decrease in size.
Diameter-7.2 u
Nucleus is absent
Heamoglobin is present.
Time required for erythropoiesis :
●
Stages ●
Days required
●
From proerythroblast to matured ●
7 days
RBC.
●
Up to the stage of reticulocyte ●
5 days
● ●
●
From reticulocyte to become ●
2 days
matured RBC.
