Objectives:
To compare the effectiveness of different oral analgesics for relieving pain and distress in
adults following the extraction of teeth and deep cavity preparations under local
anesthesia
Results:
There were significant decreases in mean pain VAS scores for diclofenac potassium
group compared to paracetamol and ibuprofen groups at 4 hours postoperatively (one-
way Analysis of Variance: p=0.0001, p=0.001) and 6 hours postoperatively
(p=0.04, p=0.005). Changes in distress scores from the preoperative score to the
postoperative score were made using the paired sample t-test. There were significant
decreases in distress scores between the preoperative and postoperative scores (p=0.0001)
Saudi Med J. 2017 Mar; 38(3): 284–291.
doi: 10.15537/smj.2017.3.16023
PMCID: PMC5387905
PMID: 28251224
Comparison of paracetamol, ibuprofen, and
diclofenac potassium for pain relief following dental
extractions and deep cavity preparations
Giath Gazal, PhD and Khalid H. Al-Samadani, PhD
Abstract
Analgesic effects of ibuprofen immediate‐release/extended‐release (IR/ER) 600‐
mg tablets were evaluated in 2 randomized, double‐blind, placebo‐controlled
dental pain studies.
Conclusions
Ibuprofen 600 mg IR/ER demonstrated analgesic efficacy superior to placebo in
the third‐molar dental pain model after single and multiple doses. Ibuprofen
IR/ER provided both a rapid onset of analgesia and a 12‐hour duration of effect
and was safe and well tolerated, with dosing lasting up to 2 days. A post hoc
analysis suggested that ibuprofen provides faster onset of analgesia and a
superior duration of effect compared with a single dose of naproxen sodium 220
mg. Thus, ibuprofen IR/ER provides a long‐acting formulation of ibuprofen that
offers the benefits of fast and sustained pain relief plus the convenience of less
frequent dosing for patients with longer‐lasting pain.
Analgesic Efficacy of a New Immediate‐
Release/Extended‐Release Formulation of
Ibuprofen: Results From Single‐ and
Multiple‐Dose Postsurgical Dental Pain
Studies
Steven Christensen
Ed Paluch
Shyamalie Jayawardena
Stephen Daniels
Suzanne Meeves
Article Analysis & Evaluation
Preoperative Oral Use of Ibuprofen or
Dexamethasone May Improve the
Anesthetic Efficacy of an Inferior
Alveolar Nerve Block in Patients
Diagnosed With Irreversible Pulpitis
Author links open overlay panelJohn M.NussteinDDS, MS
Subjects Dental pain
One hundred and sixty-five patients were recruited for the study. Patients
were all diagnosed as having a mandibular molar with asymptomatic irre-
versible pulpitis. Patients had not taken any analgesics within 12 h before
treatment.
Key Exposure/Study Factor
The primary exposure was use of one of the preoperative oral medications
- ibuprofen (400 mg), dexamethasone (0.5 mg), or placebo (lactose). One
hour after receiving the oral medication, an inferior alveolar nerve block
was delivered using 1.8 mL 2% lidocaine with 1:80,000 epinephrine. After
waiting 15 min, soft tissue anesthesia (lip numbness) and pulpal anesthesia
(negative response to cold testing) were assessed, the treatment tooth was
isolated, and endodontic access started.
Main Results
Success rates were reported as 12.7% with placebo, 38.2% with dexameth-
asone, and 25.5% with ibuprofen. Presumably the chi-square tests showed
a statistically significant difference in success rate between dexamethasone
and placebo. No statistically significant difference in success was reported
between ibuprofen and placebo or between ibuprofen and dexametha-
sone. The test used was unclear and no adjustment was made for multiple,
between-group comparisons. It was also unclear what the ANOVA test was
used for, because there was no interval scaled data included in the analyses.
