LATE BHAGIRATHI YASHWANTRAO PATHRIKAR
COLLEGE OF PHARMACY, PATHRI. (Tq. Phulambri
Dist. Aurangabad)
Year 2022-2023
PROJECT TITLE:
A REVIEW OF RECENT MEDICINAL
PROPERTIES OF TERMINALIA ARJUNA
PRESENTED BY:- SANJANA R. GAIKWAD
CLASS:- B.PHARM IVTH YEAR
PRN No:- 2025473823065
GUIDE BY:- Ms. ASHWINI THORAT
PRINCIPAL:- Dr. GAJANAN SANAP
CONTENTS
Tittle
Index
Introduction
Literature review
Objective
Main course of your journal
Reference
Thank you
INTRODUCTION:
The fruits and bark of various species of Terminalia
(Combretaceae) trees have been used since the Vedic period
(1500–500 BC) in the treatment of cardiac disorders.
In addition to its beneficial use in cardiovascular ailments,
the aqueous and/or alcoholic extracts of the bark of this tree
have been shown to possess anti-cancer and antimicrobial.
Currently High Performance Thin Layer Chromatography
(HPTLC) is used as an alternative to HPLC for the
quantification of plant chemicals because of its simplicity,
accuracy, cost effectiveness and rapidity.
Scientific Classification
Kingdom: Plantae
Phylum: Tracheophyta
Class: Magnoliopsida
Order: Myrtales
Family: Combretaceae
Material of method
Plant material and extraction
The Department of Botany at the University
of Mysore in Mysore certified the T. arjuna
bark samples that were procured from
Mysore, India
It defatted with diethyl ether for 24 hours,
then the same materials were extracted with
ethyl alcohol for 72 hours.
Under low pressure, the extract was filtered
and dried
DNA damage protection assay
Determination of oxidative plasmid DNA strand
breakage Conversion of plasmid DNA from super coiled
form to open circular and further linear form is an
indication of DNA damage
Quantification of total polyphenols and flavonoids
Oxidation of protein was assayed by Kwon et al15 with
slight variations. Oxidation of BSA( 5 mg) in
phosphate buffer was initiated by 20 mM AAPH and
inhibited by different excerpts ofT. arjuna( 100 mg/ ml).
The absorbance of blue- multicolored fusions recorded
after 40 min at 725 nm against blank.
LITERATURE SURVEY
1] Singh D.V., Verma R.K., Singh S.C., Gupta M.M. RP-LC, 2002.
The pharmacognosy, phytochemistry, pharmacology and clinical
use of one of the species, Terminalia arjuna Such as useful in the
treatment of cancer, fungicidal, antimicrobial, antibacterial etc.
2] Singh G., Singh A.T., Abrahama A, 2008.
The bark of Terminalia arjuna (Roxb.) Whight and Arnot, a
deciduous tree of Combretaceae family, has been widely used
since Vedic period for the treatment of various heart diseases
Its usefulness in several cardiac complications like cardiac failure,
hypertension and other digitalis unresponsive cardiac diseases.
ADVANTAGES
This plant has a good safety outline when used in
combination with other conventional drugs.
This review highlights various medicinal properties of T.
arjuna through different studies such as antioxidant,
hypotensive, anti-atherogenic, anti-inflammatory, anti-
carcinogenic, anti-mutagenic and gastro-productive effect.
DISADVANTAGES :
Consumption of arjuna is associated with mild side effects
like body ache, headache, gastritis, and nausea.
Consuming arjuna plant extract, which is the key component
of Arjunarishta, can lead to liver toxicity
and hypothyroidism.
PROPERTIES:
Medicinal properties of Terminalia arjuna are as follows :
Terminalia arjuna, commonly known as arjuna, belongs
to the family of Combretaceae.
Its bark decoction is being used in the Indian
subcontinent for anginal pain, hypertension, congestive
heart failure, and dyslipidemia, based on the observations
of ancient physicians for centuries.
OBJECTIVE
This plant has a good safety outline when used in
combination with other conventional drugs.
This review highlights various medicinal properties of
T. arjuna through different studies such as antioxidant,
hypotensive, anti-atherogenic, anti-inflammatory, anti-
carcinogenic, anti-mutagenic and gastro-productive
effect.
CONCLUSION :
A simple, reliable, cost-effective and rapid green
synthesis of Au NPs using T. arjuna leaf extraction
is reported.
The synthesized gold nanoparticles have particle
sizes in the range of 20–50 nm with the spherical
nature.
There was no carcinogenic and cytotoxic effect of
the cells and pollen grains.
REFERENCES :
1. Singh D.V., Verma R.K., Singh S.C., Gupta M.M. RP-LC
determinationof oleane derivatives in Terminalia
arjuna. J Pharm Biomed Anal. 2002;28:447–452. [PubMed].
2. Singh G., Singh A.T., Abrahama A. Protective effects
of Terminalia arjuna against doxorubicin-induced
cardiotoxicity. J Ethnopharmacol. 2008;117:123–
129. [PubMed] .
3. Harbone J.B. 3rd ed. ChapmanandHall; London: 1998.
Phytochemical Methods; pp. 117–119.
