DRUGS TO AVOID IN G6PD DEFICIENCY

Commonly used drugs which have a definite risk of haemolysis if given in patients suffering
from G6PD deficiency and should be completely avoided:

PHARMACOLOGICAL CLASS DRUGS

Nitrofurans
ANTIBIOTICS Nitrofurantoin
Nitrofurazone
Quinolones
Ciprofloxacin
Moxifloxacin
Nalidixic Acid
Norfloxacin
Ofloxacin
Sulfonamides
Co-trimoxazole
Sulfadiazine
Sulfamethoxazole
Sulfasalazine

Chloramphenicol
Furazolidone
ANTI MALARIALS Primaquine

Dapsone
ANTI MYCOBACTERIALS Para Aminosalicylic Acid (PAS)

URINARY ANALGESICS Pyridium(phenyzopridine)

ANTI NEOPLASTIC DRUGS Doxorubicin

Rasburicin

VITAMINS Vitamin C (IN HIGH Doses)

 DEFINITE RISK OF HAEMOLYSIS POSSIBLE RISK OF HAEMOLYSIS

Deffciency
Pharmacological Pharmacological
Drugs* Drugs*

G6PD
Class Class
Anthelmintics • ß-Naphthol Analgesics • Acetylsalicylic acid
• Niridazole (Aspirin)
• Stibophen • Acetanilide
• Paracetamol
Antibiotics • Nitrofurans (Acetaminophen)
- Nitrofurantoin • Aminophenazone
- Nitrofurazone (Aminopyrine)
• Quinolones • Dipyrone
- Ciprofloxacin (Metamizole)
- Moxifloxacin • Phenacetin
- Nalidixic acid • Phenazone
- Norfloxacin (Antipyrine)
- Ofloxacin • Phenylbutazone
• Chloramphenicol • Tiaprofenic acid
• Sulfonamides
- Co-trimoxazole Antibiotics • Furazolidone
(Sulfamethoxazole + • Streptomycin
Trimethoprim) • Sulfonamides
- Sulfacetamide - Sulfacytine
- Sulfadiazine - Sulfaguanidine
- Sulfadimidine - Sulfamerazine
- Sulfamethoxazole - Sulfamethoxypyridazole
- Sulfanilamide Anticonvulsants • Phenytoin
- Sulfapyridine
- Sulfasalazine Antidiabetics • Glibenclamide
(Salazosulfapyridine)
- Sulfisoxazole Antidotes • Dimercaprol (BAL)
(Sulfafurazole) Antihistamines • Antazoline (Antistine)
• Diphenhydramine
Antimalarials • Mepacrine
• Pamaquine • Tripelennamine

• Pentaquine Antihypertensives • Hydralazine

• Primaquine • Methyldopa

Antimethemo- • Methylene blue Antimalarials • Chloroquine & derivatives

globinaemic Agents • Proguanil
• Pyrimethamine
Antimycobacterials • Dapsone • Quinidine
• Para-aminosalicylic acid
• Quinine
• Sulfones
- Aldesulfone sodium Antimycobacterials • Isoniazid
(Sulfoxone)

- Glucosulfone Antiparkinsonism Agents • Trihexyphenidyl

- Thiazosulfone (Benzhexol)

Antineoplastic Adjuncts • Doxorubicin Cardiovascular Drugs • Dopamine (L-dopa)

• Rasburicase • Procainamide
• Quinidine
Genitourinary Analgesics • Phenazopyridine Diagnostic Agent • Toluidine blue
(Pyridium) for Cancer Detection

Others • Acetylphenylhydrazine Gout Preparations • Colchicine

• Phenylhydrazine • Probenecid

Hormonal Contraceptives • Mestranol

Nitrates • Isobutyl nitrite

Vitamin K Substance • Menadiol Na sulfate

• Menadione
• Menadione Na bisulfite
• Phytomenadione

Vitamins • Ascorbic acid (Vit C)

(rare)

Others • Arsine
• Berberine
(in Coptis chinensis)
• Fava beans
• Naphthalene
(in mothballs)
• Para-aminobenzoic acid