Attention Deficit Hyperactivity Disorder
(ADHD)
PSY4105
Dr. Caroline Sullivan
Today
   ADHD
    ◦ Diagnostic criteria
    ◦ Course & etiology
    ◦ Comorbid conditions
    ◦ Neuropsychological deficits
    ◦ Functional deficits
       Academic
       Family
       Social
   Next time:
    ◦ Evaluation and treatment
Fact or Fiction?
   ADHD usually persists into adulthood
    ◦ FACT
   People with ADHD have average IQ
    ◦ FACT
   ADHD only affects boys
    ◦ FICTION
   Children with ADHD who take medication are more
    likely to abuse drugs when they become teenagers
    ◦ FICTION
Fact or Fiction? (cont’d)
   The rate of diagnoses of ADHD in children is increasing
    ◦ FACT
   Children are more likely to show signs of ADHD if they
    consume a lot of food dyes
    ◦ FICTION
   Kids with ADHD are more likely to repeat grades
    ◦ FACT
   A diagnosis of ADHD is more likely than physical
    conditions to lead to long-term economic disadvantage
    ◦ FACT
      What is Attention-Deficit /
      Hyperactivity Disorder (ADHD)?
               ADHD is a
        neurobiological problem
           that is usually first
        noticed in the preschool
        and early school years.
Inattention    Hyperactivity   Impulsivity
Symptoms of Inattention
At least 6 of 9 symptoms:
        Poor attention to details,
         makes careless mistakes
        Difficulty concentrating
        Doesn’t seem to listen
        Fails to follow through on
         instructions & finish work
        Difficulty organizing work and
         self
        Avoids/dislikes lengthy,
         effortful tasks
        Loses things                   Meet my son, Marleau
        Easily distracted
        Forgetful
    Types of Attention
1)       Attention capacity:
          Can’t remember phone number unless you write it down
2)       Selective Attention:
          Distraction – can’t do homework if tv on in another room
3)       Sustained Attention:
          Ability to pay attention when tired or disinterested in the
           subject
Which is the primary deficit in ADHD?
◦        Sustained attention – especially for repetitive,
         structured, and uninteresting tasks
Symptoms of Hyperactivity & Impulsivity
At least 6 of 9 symptoms:
     Fidgets or squirms
     Leaves seat when not
      appropriate
     Runs or climbs excessively
     Difficulty playing quietly
     “On the go” or “driven by
      a motor”
     Blurts out answers to
      questions
     Talks excessively
     Difficulty awaiting turn
     Interrupts or intrudes on
      others
      Which behaviours match
        which symptoms?
         Inattention                    Hyperactivity
   Poor attention to details,      Fidgets or squirms
    makes careless mistakes         Leaves seat when not
  Difficulty concentrating         appropriate
  Doesn’t seem to listen           Runs or climbs excessively
  Fails to follow through on       Difficulty playing quietly
    instructions & finish work      “On the go” or “driven by a
  Difficulty organizing work and   motor”
    self
  Avoids/dislikes lengthy,
                                          Impulsivity
    effortful tasks                 Talks excessively
  Loses things                     Difficulty awaiting turn
  Easily distracted                Interrupts or intrudes on
                                    others
  Forgetful
                                    Blurts out answers to
◦* Associated with poor academic
                                    questions
performance *
            Symptoms must be.....
Persistent         Pervasive        Impairing
( > 6 months)      ( > 1 setting)
2 Dimensions - 3 Specifiers
Inattentive        Hyperactive /
 Subtype            Impulsive
  “ADD”              Subtype
         Combined Type
         “Classic ADHD”
    DSM-5
Major Changes:
•   ADHD is categorized under neurodevelopmental disorders
•   Subtypes changed to “specifiers of current presentation”
•   Is more relevant for diagnosis of adult ADHD
Moderate Changes:
   “Age of onset” criteria changed – symptoms before age 12
Minor Changes:
   Requirement of multiple informants included
   Autism and PDD have been removed from exclusionary
    criteria
   More examples of symptoms
Prevalence
 7-12% of school age population worldwide
 2nd most prevalent children’s mental health
  disorder
 Most prevalent referral in mental health clinics
 Male bias
   In Ontario
     2.1 millions students
     ~ 100,000 with ADHD
     1-3 students per class
            ADHD & Gender
 2-4% of girls
 6-9% of boys
     But referral, assessment and diagnosis of boys with
      ADHD is much more common (2.5:1)
     Clinical sample: 6:1
 Inattention type is relatively more
  common in girls
 Slightly more common with lower SES
ADHD is a neurodevelopmental disorder
“An illness of the central nervous
system caused by known genetic,
  metabolic, or other biological
             factors”
Parts of the brain involved in ADHD
              Superior       Frontal        Anterior
               Parietal     Eye Field       Cingulate
     Posterior Lobe                          Gyrus
         Area                                        Frontal
                                                     Area
 Temproparietal
      Junction
                                                     Prefrontal
                                                     Cortex
   Thalamus
    Pulvinar
      Superior
     Colliculus
                          Posner & Rothbart (2007), Annual Rev
                                                        Psych
 ADHD persists into adolescence &
   adulthood, but changes in its
    behavioural manifestation
Childhood     Adolescence         Adulthood
1o Combined    1o Inattentive   1o Inattentive
    Type            Type             Type
 OVERT                          COVERT
    Course
   Infancy – difficult temperament
    ◦   Irritable
    ◦   Over-active
    ◦   Unpredictable behaviour
    ◦   Erratic eating and sleeping
   Preschool – symptoms become noticeable
    ◦   Impulsive behaviour
    ◦   Easily bored
    ◦   Over-reactive emotionally
    ◦   Non-compliance and defiance
Course
   Early school years– diagnosis often made
    ◦   School requires attention and compliance
    ◦   Defiance and conduct problems increase
    ◦   Academic/learning problems
    ◦   Hyperactivity slowly declines
   Adolescence
    ◦ Many individuals “outgrow” ADHD symptoms
      in adolescence
    ◦ Symptoms continue for about 50% of children
    ◦ By adulthood, individuals with ADHD perform
      normally on most measures of attention
Functional Deficits
    Etiology
   Genetic influences
    ◦ Strongly genetic
    ◦ 80% heritability
 Reduced dopaminergic activity
 Reduced blood flow in the frontostriatal
  networks
Etiology
   Many poorly supported or discredited
    theories exist to explain ADHD
    ◦ Food allergies
    ◦ Poor parenting techniques
      If anything, bidirectional causality
    ◦ Vaccines ( )
 Sugar consumption and exposure to
  screen time can increase ADHD
  symptoms but do not cause it
80% Comorbidity
   Learning disorders = 25%
    ◦ Especially writing disorder
   Oppositional Defiant Disorder (ODD) = 50% by age 7
   Anxiety disorders = 25%
   Mood disorders = 20-30%
   Tics = 20%
   Sleep disorders = 20%
   Risk-taking behaviours and substance use
Neuropsychological Findings
What is working memory?
             A limited-capacity cognitive
system that allows us to actively hold and use critical
   information in mind despite ongoing distraction
  Auditory-Verbal                  Visual-spatial
  E.g. Digit span                 E.g. CogMed
        Working Memory is
        Impaired in ADHD
Many people with ADHD exhibit significant
 impairments in working memory:
   • Particularly those with symptoms of inattention
   • Particularly for visual-spatial information
   • Impairments evident across all ages, but diminish in
     adolescence
   • Problems evident on standardized tests
   • Working memory is the one cognitive impairment
     that is really important in education!
Let’s think about how working
memory deficits might affect:
 Learning the alphabet
 Following a conversation
 Writing a paragraphe
 Playing a game (e.g. cards)
 Learning to add and substract
 Genetic basis
 Persists into adulthood
 Neurocognitive disorder – not just a
  behavioural disorder
 Neuropsychological deficits (particularly
  working memory) central to ADHD
 Inattention, not hyperactivity/impulsivity, is
  key in learning problems