Erectile Dysfunction ttional Kidney and Urologic Diseases Information Clearinghouse What is erectile dysfunction (ED)? Erectile dysfunction is a condition in which a man is unable to get or keep an erection firm enough for sexual intercourse. ED is [NIHY) present when a man Corpora cavernosa aco, + can get an erection sometimes, though Urethra ‘ene bese not every time Tunica albuginea Corpus + can get an erection, yet it does not last spongiosum ong enough for sexual intercourse + isunable to get an ere at any time Gross section ofthe penis ED is sometimes called impotence; however, health care providers use this An erection requires a precise sequence term less often now. of events: * An erection begins with sensory or How does an erection occur? ‘mental stimulation, or both. The An erection occurs when blood flow stimulus may be physical—touch, increases into the penis, making it expand sound, smell, sight—or a sexual image and become firm. ‘Two long chambers, or thought. inside the penis, called the corpora cavernosa, contain a spongy tissue that draws the blood into the chambers. The spongy tissue contains smooth muscles, fibrous tissues, blood-flled spaces, veins, and arteries. A membrane, called the tunica albuginea, encases the corpora cavernosa. The urethra, which is the tube it sends impulses to local nerves in the penis that cause the muscles of the corpora cavernosa to relax. As a result, blood flows in through the arteries and fills the spaces in the corpora cavernosa like water filling a i ‘ sponge. that carries urine and semen outside of ones the body, runs along the underside of the * The blood creates pressure in the corpora cavernosa in the middle of a third corpora cavernosa, making the penis chamber called the corpus spongiosum. ‘expand.+ The tunica albuginea helps trap the blood in the corpora cavernosa, thereby sustaining the erection. + The erection ends after climax or after the sexual arousal has passed. The muscles in the penis contract to stop the inflow of blood. The veins open and the extra blood flows out of the spaces and back into the body. What causes erectile dysfunction? A variety of physical and psychological or emotional issues can cause ED. Physical causes include damage to the nerves, arteries, smooth muscles, and fibrous tissues in the penis. Diseases and disorders that cause damage and can lead to ED include + high blood pressure + diabetes, a complex group of diseases characterized by high blood glucose, also called high blood sugar or hyperglycemia + atherosclerosis, the buildup of a substance called plaque on the inside of arteries: + heart and blood vessel disease + chronic kidney disease 2. Erectile Dysfunction + multiple sclerosis, an autoimmune disease that attacks the nerves, * injury from treatments for prostate cancer, including radiation and prostate surgery * injury to the penis, spinal cord, prostate, bladder, or pelvis * surgery for bladder cancer + Peyronie’s disease, a disorder in which scar tissue, called a plaque, forms in the penis Lifestyle choices, such as smoking, drinking too much alcohol, using illegal drugs, being overweight, and not exercising, can lead to ED. Psychological or emotional issues, such as the following, can also contribute to ED: + anxiety + depression + fear of sexual failure + guilt + low self-esteem + stress Even when ED has a physical cause, psychological or emotional factors may make the condition worse. For example, aphysical problem that slows a man’s sexual arousal can create anxiety, which can worsen the ED. In addition, ED can be a side effect of many common medications, such as blood pressure medications, antihistamines, antidepressants, tranquilizers, appetite suppressants, and ulcer medications. MedlinePlus, a website of the U.S. National Library of Medicine, provides a list of specific medications that can cause ED. Read more at www.nlm.nih.gov/ medlineplus/ency/article/004024.htm. Assmall number of ED cases result from a reduced level of the male hormone testosterone. Who is more likely to develop erectile dysfunction? Men with an underlying disease that can cause ED are more likely to develop ED. ED affects men of all races and in all regions. Researchers estimate that ED affects as many as 30 million men in the United States.| While the likelihood of ED increases with age, the aging process does not cause ED. For example, ED ‘occurs in + about 12 percent of men younger than 60 + 22 percent of men age 60 to 69 + 30 percent of men age 70 or older !Nunes KP Labazi H, Webb RC. New insights into hypertension associated erectile dysfunction. Current Opinion in Nephrology and Hypertension. 2012;21(2):163-170 AHeidelbaugh JJ. Management of erectile dysfunction. American Family Physician 2010;81(3):305-312, 3. Erectile Dysfunction —_— Seek Medical Attention for Erectile Dysfunction, Which May Indicate a More Serious Condition Erectile dysfunction is a medical problem and requires medical attention A man who has ED for more than several weeks or a few months should see his health care provider. If he has other health issues, such as diabetes or heart disease, new ‘or worsening ED may be a sign that the other condition needs attention. Men may find it difficult to talk with ‘a health care provider about ED; however, they should remember that a healthy sex life is part of a healthy life. ‘The health care provider may refer a ‘man with ED to a urologist—a doctor who specializes in sexual and urinary problems.What are the complications of erectile dysfunction? Complications of ED may include + an unfulfilled sex life ‘+ emotional problems such as depression, anxiety, and low self-esteem + loss of intimacy between the couple, resulting in a strained relationship + the inability pregnant to get the partner How is erectile dysfunction diagnosed? A health care provider diagnoses ED with a ‘+ medical and sexual history + physical exam Other tests that may be helpful to the health care provider include + blood tests + a nocturnal, or nighttime, erection test + an injection test + a Doppler ultrasound + a mental health exam Medical and Sexual History ‘Taking a medical and sexual history is one of the first things a health care provider may do to help diagnose ED. He or she will ask the patient to provide information, such as + how the patient would rate his confidence that he can get and keep an erection + how often the patient's penis is hard enough for penetration when he has erections from sexual stimulation 4 Erectile Dysfunction * how often the patient is able to maintain his erection after penetration uring sexual intercourse * how often sexual intercourse is satisfying for the patient + if the patient has an erection when he wakes up in the morning + how the patient would rate his level of sexual desire * how often the patient is able to reach climax and ejaculate * any operations that may have damaged the nerves or blood vessels near the patient's penis * any prescription or over-the-counter medications the patient may take * if the patient uses illegal drugs, drinks alcohol, or smokes ‘This information will help the health care provider understand the problem and define the degree and nature of the ED. ‘The medical history can show diseases that ead to ED, and reviewing sexual activity can help diagnose problems with sexual desire, erection, ejaculation, or orgasm. Physical Exam A health care provider will perform a physical exam to help diagnose the causes of ED. During a physical exam for ED, a health care provider most often * checks the penis to determine if it is sensitive to physical touch. If the penis lacks sensitivity, a problem nervous system may be the cause. the * checks for unusual characteristics of the penis itself, which could suggest the source of the problem. For example, Peyronie's disease causes the penis to bend or curve when erect.* looks for loss of body hair or breast enlargement, which can point to hormonal problems. + checks blood pressure. + checks the pulse in the wrist and ankles to determine if the patient has a problem with circulation. Blood Tests A blood test involves drawing blood at a health care provider's office or a commercial facility and sending the sample to a lab for analysis. Blood tests, can uncover possible causes of ED, stich as diabetes, atherosclerosis, chronic kidney disease, and hormonal problems. Nocturnal Erection Test During a nocturnal erection test, done at home or in a special sleep lab, the patient ‘wears a plastic, ringlike device around the penis to test whether he has erections during the night while he sleeps. If the patient has an erection, the device will break. A more complicated version of this test uses an electronic monitoring device that will record how firm the erections are, the number of erections, and how long. they last. Each night during deep sleep, a man normally has three to five erections. If the man has erections during either type of test, he is physically capable of having an erection and the cause of the ED is more likely a psychological or emotional issue. If the man does not have erections during cither test, the ED is more likely due to a physical cause. 5. Erectile Dysfunction Injection Test During an injection test, also called intracavernosal injection, a health care provider will inject a medication into the base of the penis to cause an erection, In some instances, a health care provider may insert the medication into the urethra, instead of using an injection, to cause an erection, The health care provider will evaluate how full the penis becomes and. how long the erection lasts. Bither test helps the health care provider find the cause for the ED. The tests most often take place in a health care provider's office. Doppler Ultrasound An cray technician most often performs a Doppler ultrasound in a health care provider's office or an outpatient center. The ultrasound can detect poor blood flow through the penis. An x-ray technician passes a handheld device lightly over the penis to measure blood flow. Color images ‘on a computer screen show the speed and direction blood is flowing through a blood vessel. A radiologist—a doctor who specializes in medical imaging—or urologist interprets the images, During this exam, a health care provider may inject medication into the penis to create an erection. Mental Health Exam A health care provider may interview the patient and use a questionnaire to help diagnose any psychological or emotional issues that may be causing the ED. The health care provider may also interview the patient's sexual partner to gather more information about the couple’s emotional and physical relationship and how it may affect the ED.