GROUP 4
Antituberculosis
Medications
Barrera, Nicole Anne L.
Hassan, Rafia G.
Jardeleza, Kaye Knorel O.
Mustapa, Nurul Ezza S.
Sauragal, Arnaiza
Wong, Bernice
Antituberculosis Medications
Rifampicin Isoniazid Pyrazinamide Ethambutol Streptomycin
Commonly Used
Nursing Considerations
Agents Adult Dosage Common Side Effects
1. Monitor liver function regularly due to the risk of
hepatotoxicity.
Upset Stomach 2. Advise the patient to take the medication with food to
0 mg/kg to 600 Heartburn minimize gastrointestinal upset.
mg/day IV daily Nausea 3. Educate the patient on the importance of completing
or Menstrual Changes the full course of antibiotics.
Rifampicin
8-12 mg/kg once Headache 4. Monitor the patient for potential drug interactions,
daily PO Drowsiness especially with anticoagulants and certain HIV
Tired feeling, or medications.
Dizziness 5. Instruct the patient to report any signs of adverse side
effects, such as jaundice, rash, or flu-like symptoms.
Dark Urine
Loss of appetite 1. Monitor for altered mental status
Nausea and/or vomiting 2. Promote activity and adequate nutrition.
300 mg Numbness, tingling, burning, 3. Monitor for dehydration
Isoniazid Once a day, or pain in hands and feet 4. Encourage the patient to eat small, frequent meals
IM Weakness 5. Assist in developing a daily schedule of rest
Yellow eyes or skin 6. Incorporate appropriate safety measures
Unsteadiness
Commonly Used
Nursing Considerations
Agents Adult Dosage Common Side Effects
1. Monitor liver function regularly
2. Evaluate renal function through serum creatinine and
Nausea and Vomiting BUN tests.
Joint Pain 3. Screen for gout
15 to 30 mg/kg
Hepatotoxicity 4. Educate patients about common side effects
once daily, taken
Pyrazinamide Hyperuricemia 5. Watch for skin rashes
orally
Rash 6. Instruct patients to take Pyrazinamide with food
GI Distress 7. Emphasize the importance of medication compliance.
Hepatitis 8. Check for potential drug interactions.
1. Be alert for signs of hepatitis, including anorexia.
2. Monitor signs of agranulocytosis, methemoglobinemia, or
other unusual weakness and fatigue.
headache 3. Monitor signs of hypersensitivity or anaphylactoid reactions,
loss of appetite including pulmonary symptoms and skin reactions
Ethambutol 275 mg PO OD
4. Assess dizziness that might affect gait, balance, and other
upset stomach
nause/vomitting functional activities
5. Be alert for confusion, hallucinations, or other alterations in
mental status
Commonly Used
Nursing Considerations
Agents Adult Dosage Common Side Effects
1. Check the injection site for signs of irritation,
redness, and swelling
2. Assess the renal function regularly
Hearing loss
3. Watch for signs of allergy, such as itching, rash,
500 to 1000 mg Loss of balance
swelling, and severe dizziness.
Streptomycin IM once daily Skin irritation
4. Monitor for nephrotoxicity and keep an eye out
Fever or chills
for kidney damage.
References
Isoniazid (Oral Route, Intramuscular Route) Proper Use - Mayo Clinic. (2023).
Mayoclinic.org. https://www.mayoclinic.org/drugs-supplements/isoniazid-oral-
route-intramuscular-route/proper-use/drg-20064419
Isoniazid (Oral Route, Intramuscular Route) Side Effects - Mayo Clinic. (2023).
Mayoclinic.org. https://www.mayoclinic.org/drugs-supplements/isoniazid-oral-
route-intramuscular-route/side-effects/drg-20064419?p=1
Rifampicin. (n.d.). Search Drug Information, Interactions, Images, Dosage & Side
Effects | MIMS Philippines.
https://www.mims.com/philippines/drug/info/rifampicin?mtype=generic
Rifampicin drug study. (n.d.). Scribd.
https://www.scribd.com/document/204766717/Rifampicin-Drug-Study
Ethambutol. (n.d.). McGraw Hill Medical.
https://fadavispt.mhmedical.com/content.aspx?bookid=1873§ionid=139010752
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