Name/ Classificatio Available Indicatio Administratio Mechanism of Adverse Interactions Contraindications/ Nursing Patien

Generic n Forms n and n Action Reactions Cautions Consideration Teachi

Name/Brand dosages s
Name (Application of
Nursing
Process)
Oral anti- Tablet Indicatio Swallow the Alteration of the Bloating, Metformin can Contraindication includes Metformin is a Metform
Metformin diabetic drug and n tablet or energy Gas, interact with some hypersensitivity, chronic first-line drug should
in Solution Metformin extended- metabolism of Diarrhea, diabetes heart failure, metabolic used in the taken
the biguanide is release tablet the cell. Belly pain, medications that acidosis with or without treatment of with
class for the indicated whole with a Metformin exerts Constipation decrease blood coma, diabetic ketoacidosis type 2 diabetes meals t
treatment of as an full glass of its prevailing, , Little glucose, including (DKA), severe renal disease, and must be help
type 2 adjunct to water. Do not glucose- appetite insulin, glipizide abnormal creatinine given with food reduce
diabetes diet and crush, break, or lowering effect (Glucotrol XL), and clearance resulting from to minimize GI stomac
mellitus, in exercise chew it. by inhibiting repaglinide. It may shock, septicemia, or symptoms. In or bowe
particular, in to improve hepatic also interact with myocardial infarction and addition, side
overweight glycemic gluconeogenesi medications that lactation. metformin must effects
and obese control in s and opposing can raise blood be stopped 48 that ma
people and adults and the action of glucose. Examples hours before occur
those with pediatric glucagon. of these and after during t
normal kidney patients medications radiologic first few
function. ≥10 years include prednisone studies and weeks
old with and should be used treatme
type 2 hydrochlorothiazid cautiously in .
diabetes e (Microzide). patients with
mellitus. Topiramate impaired renal
(Topamax), function.
Dosage cimetidine
(Tagamet HB).
500 mg Alcohol can also
orally interact with
twice a metformin and
day or increase the risk of
850 mg lactic acidosis.
orally
once a
 day.

Name of Student: Althea Sophia G. Mordeno

I: ANTI DIABETIC DRUGS:

II: CORTICOSTEROIDS

Name/Generic Classification Availabl Indication and dosages Administration Mechanism of Adverse Interactions Contraindicatio Nursing Pat
Name/Brand e Forms Action Reactions ns/Cautions Consideratio
Name ns
(Application
of Nursing
Process)
Mineralocorticoi tablet Indication It can be taken They sensitize blood salt and water Fludrocortisone may Fludrocortisone It is Take th
Fludrocortisone d form As partial replacement orally with or vessels to the effects retention. This interact with aspirin, acetate tablets recommende mouth
therapy for primary or without a meal. of NE and they can lead to: amphotericin B, (corticosteroids) d to measure water.
secondary adrenocortical retain sodium and low diuretics (water are blood directio
insufficiency in Addison's expand volume. potassium. pills), digoxin, contraindicated in pressure prescri
disease. This can lead phenytoin, rifampin, patients with regularly it with
to: birth control pills or systemic fungal while using avoid s
Dosage weak, fragile hormone infections and in this you are
Oral Route bones replacement therapy, those with a corticosteroid medici
50 to 200 micrograms a day (osteoporosis) blood thinners, history of as it has been take it
stomach insulin or oral possible or associated
ulcers. diabetes known with
slow wound medications, hypersensitivity iatrogenic
healing. steroids, or to these agents. hypertension.
thin or easily barbiturates. Serial plasma
bruised skin. renin activity
headaches. should also
trouble be checked.
sleeping. If there is
weakness,
muscle
cramps,
blood
 electrolytes
should be
checked to
identify and
treat
hypokalemia.
Prednisone Glucocorticoid Tablet Indication Prednisone is Prednisone mental Prednisone (Rayos) Prednisone is Monitor Alway
and Prednisone is an FDA- usually taken with decreases depression, interacts with contraindicated in personality exactly
Solution approved, delayed-release food one to four inflammation via mood swings, medications like patients with changes, Once y
corticosteroid indicated as times a day or once suppression of the mistaken warfarin (Coumadin, documented including prednis
an anti-inflammatory or every other day. migration of feelings of Jantoven), NSAIDs hypersensitivity depression, than 2
immunosuppressive agent polymorphonuclear self like ibuprofen to the drug or euphoria, import
to treat a broad range of leukocytes and importance or (Advil, Motrin), and components of restlessness, taking
diseases, including reversing increased of being antibiotics like the formulation. hallucination When
immunosuppressive/endocri capillary mistreated ciprofloxacin Contraindications s, and prednis
ne, rheumatic, collagen, permeability. It also signs and (Cipro). It can also to the psychosis. or long
dermatologic, allergic suppresses the symptoms of interact with live administration of stops m
states, ophthalmic, immune system by high blood vaccines like the prednisone steroid
respiratory, hematologic, reducing the activity sugar such as MMR (measles, include the the pre
neoplastic,and edematous. and the volume of being more mumps, and rubella) presence of by mou
the immune system. thirsty or vaccine. systemic fungal steroid
Dosage hungry or infections.
oral tablet, which comes in having to
5 milligrams (mg) urinate more
oral solution, which comes than normal.
in: You may also
5 mg per 5 milliliters feel very tired
(mg/mL) or have blurry
10 mg/5 mL vision.
15 mg/5 mL
20 mg/5 mL sudden weight
25 mg/ 5 mL gain
30 mg/ 5 mL swelling of
the feet or
lower legs
Side effects
 that usually
do not require
medical
attention
(report to your
doctor or
health care
professional if
they continue
or are
bothersome):d
izziness
headache
loss of
appetite
nausea,
vomiting
trouble
sleeping

III:HORMONAL AGENTS

Name/Generic Classification Available Indication and Administration Mechanism of Action Adverse Interactions Contraindications Nursing Patien
Name/Brand Name Forms dosages Reactions /Cautions Considerations
(Application of
Nursing Process)
ESTROGEN oral tablets, Indication It can be taken Estradiol is a nuclear Stomach upset, Some Contraindications Arrange for Instruct
Estradiol injections, It is indicated in by mouth, held hormone, meaning it nausea/vomiting, products for oral or pretreatment and take me
vaginal rings, various preparations under the acts on receptors bloating, breast that may transdermal periodic (at least directe
transdermal for the treatment of tongue, as a present inside the tenderness, interact with estrogen-based annual) history patient
patches, moderate to severe gel or patch cell, that can activate headache, or this drug therapies include: and physical, drinkin
sprays, gels, vasomotor symptoms that is applied or deactivate weight changes include: Known, which should juice du
and creams. and vulvar and vaginal to the skin, in transcription in the may occur. If any aromatase suspected, or include BP, therapy
atrophy due to through the nucleus. Estradiol of these effects inhibitors history of breast breasts, missed
menopause, for the vagina, by interacts with a target last or get worse, (such as cancer. Known or abdomen, pelvic soon as
 treatment of injection into cell receptor (Erα or tell your doctor anastrozole, suspected history organs, and a Pap remem
hypoestrogenism due muscle or fat, Erβ) within the or pharmacist exemestane, of other estrogen- smear; may not wit
to hypogonadism, or through the cytoplasm of the cell. promptly. letrozole), based cancer, i.e., increase risk of next do
castration, or primary use of an fezolinetant, uterine cancer. endometrial double
ovarian failure, and implant that is fulvestrant, Women who have cancer.
for the prevention of placed into fat, ospemifene, had a
postmenopausal among other raloxifene, hysterectomy and
osteoporosis. routes. tamoxifen, have no remaining
toremifene, evidence of
Dosage tranexamic disease are still
1 mg to 2 mg daily on acid. candidates for
a 21-day on, 7-day HRT.
off cycle
Medroxyprogesterone PROGESTIN IM Injection Medroxyprogesterone Medroxyproge Medroxyprogesteron The following Medroxypro Medroxyprogester Medroxyprogeste It is ver
acetate acetate (MPA) oral sterone e acetate (MPA) adverse effects gesterone one injections are rone should not that yo
tablets are indicated intramuscular inhibits the of has no contraindicated in be given for medicin
to treat secondary injection production of medroxyprogest known patients with a contraception directe
amenorrhea, reduce comes as a gonadotropin, erone severe history of arterial without full doctor.
the incidence of suspension preventing follicular contraceptive interactions or venous counselling more o
endometrial (liquid) to be maturation and injection have with any thromboembolic backed by the use it m
hyperplasia in injected into ovulation, which is been noted: other drugs. diseases or manufacturer’s and do
postmenopausal the buttocks or responsible for it’s oligomenorrhea, Serious patients with approved leaflet. for a lo
women, and to treat upper arm. It is ability to prevent delayed return to interactions increased risks for than yo
abnormal uterine usually given pregnancy. This action fertility, of stroke, heart ordered
bleeding due to once every 3 also thins the prolonged medroxypro disease, and may ca
hormonal imbalance, months (13 endometrium. MPA anovulation gesterone arterial vascular unwant
not organic weeks) by a reduces nuclear (temporary include: disease. effects.
pathology. healthcare estrogen receptors infertility), acitretin. medicin
provider in an and DNA synthesis in unexpected brigatinib. with a p
office or clinic. epithelial cells of the pregnancy, informa
Medroxyproge endometrium. MPA uterine
sterone can also induce p53 hyperplasia,
subcutaneous dependant apoptosis genitourinary
injection in certain cancer cell infections,
 comes as lines,6 and inhibit vaginal cysts,
suspension to GABA-A receptors.8 vaginal
be injected just hemorrhage, and
under the skin. uterine
hemorrhage.a
Androgel ANDROGEN A metered- Indication Patients AndroGel is a Acne, Alopecia, AndroGel Men with AndroGel can ANDRO
dose pump AndroGel is an should be hydroalcoholic Application Site may interact carcinoma of the cause fetal harm flamma
that delivers androgen indicated instructed to formulation that dries Reaction, with insulin, breast or known when dry. Let
20.25 mg for replacement prime the quickly when applied Asthenia, blood or suspected administered to a 1% dry
pump before
testosterone therapy in males for to the skin surface. Depression, thinners, carcinoma of the pregnant woman. smokin
using it for the
per conditions associated first time by The skin serves as a Emotional oxyphenbut prostate [see AndroGel may near an
actuation. with a deficiency or fully reservoir for the Lability, azone, or Warnings and cause serious flame. W
( 3) packets absence of depressing sustained release of Gynecomastia, corticosteroi Precautions (5.1), adverse reactions hands w
containing endogenous the pump testosterone into the Headache, ds. Tell your Adverse Reactions in nursing infants. and wa
20.25 mg testosterone. mechanism systemic circulation. Hypertension, doctor all (6.1), and Exposure of a away a
testosterone (actuation) 3 Lab Test medications Nonclinical female fetus or ANDRO
. ( 3) packets Dosage times and Abnormal, you use. Toxicology (13.1)]. nursing infant to Avoid s
containing 5 g once daily discard this Libido Women who are androgens may swimm
portion of the
40.5 mg Decreased, or may become result in varying bathing
product to
testosterone assure precise Nervousness, pregnant, or who degrees of 5 hours
. ( 3) dose delivery. Pain Breast, are breastfeeding. virilization. apply A
After the Prostate AndroGel can 1%.
priming Disorder, Testis cause fetal harm
procedure, Disorder when
patients administered to a
should pregnant woman.
completely AndroGel may
depress the
cause serious
pump one
time adverse reactions
(actuation) for in nursing infants.
every 1.25 g Exposure of a
(AndroGel female fetus or
Pump) of nursing infant to
product androgens may
required to result in varying
achieve the degrees of
daily virilization.
prescribed Pregnant women
dosage. The
or those who may
product may
be delivered become pregnant
directly into need to be aware
the palm of of the potential
the hand and for transfer of
then applied testosterone from
to the desired men treated with
application AndroGel [see
sites, either Warnings and
one pump
Precautions (5.2)
actuation at a
time or upon and Use in Specific
completion of Populations (8.1,
all pump 8.3)]. Men with
actuations known
required for hypersensitivity to
the daily dose. any of its
Alternatively, ingredients,
the product including alcohol
can be applied
and soy products.
directly to the
application
sites.
Application
directly to the
sites may
prevent loss of
product that
may occur
during transfer
from the palm
of the hand
onto the
 application
sites.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214027/#:~:text=Metformin%20is%20an%20oral%20anti,those%20with%20normal%20kidney%20function.

https://www.medicalnewstoday.com/articles/metformin-oral-tablet#:~:text=Metformin%20comes%20in%20two%20forms,caused%20by%20type%202%20diabetes.

https://www.mayoclinic.org/drugs-supplements/metformin-oral-route/proper-use/drg-20067074#:~:text=Metformin%20should%20be%20taken%20with,%2C%20break%2C%20or%20chew
%20it.

https://pubmed.ncbi.nlm.nih.gov/24393785/#:~:text=The%20centre%20of%20metformin's%20mechanism,opposing%20the%20action%20of%20glucagon.

https://www.webmd.com/diabetes/metformin-side-effects

https://www.goodrx.com/metformin/interactions

https://www.rxlist.com/metformin/generic-drug.htm#:~:text=Contraindication%20includes%20hypersensitivity%2C%20chronic%20heart,or%20myocardial%20infarction%20and
%20lactation.

https://www.myamericannurse.com/metformin-associated-lactic-acidosis/#:~:text=Nursing%20implications&text=Metformin%20is%20a%20first%2Dline,patients%20with%20impaired
%20renal%20function.

https://www.sciencedirect.com/topics/neuroscience/fludrocortisone#:~:text=Mineralocorticoids%20such%20as%20fludrocortisone%20decrease,cause%20no%20detectable%20fluid
%20retention.

https://www.ncbi.nlm.nih.gov/books/NBK564331/#:~:text=Fludrocortisone%20is%20available%20in%20tablet,to%200.2%20mg%20per%20day.

https://www.rxlist.com/florinef-drug.htm

https://www.healthline.com/health/drugs/fludrocortisone-oral-tablet

https://my.clevelandclinic.org/health/drugs/19623-fludrocortisone-tablets

https://www.medicalnewstoday.com/articles/drugs-prednisolone-oral-forms

https://medlineplus.gov/druginfo/meds/a601102.html#:~:text=Prednisone%20comes%20as%20a%20tablet,s)%20of%20day%20every%20day.
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https://www.goodrx.com/prednisone/interactions#:~:text=Prednisone%20(Rayos)%20interacts%20with%20medications,mumps%2C%20and%20rubella)%20vaccine.

https://fadavispt.mhmedical.com/content.aspx?bookid=1873&sectionid=139023075#:~:text=Monitor%20personality%20changes%2C%20including%20depression,arrhythmias%2C
%20dizziness%2C%20and%20confusion.

https://healthonline.washington.edu/sites/default/files/record_pdfs/Prednisone.pdf

https://www.webmd.com/drugs/2/drug-5186/estradiol-oral/details

https://www.rnpedia.com/nursing-notes/pharmacology-drug-study-notes/estradiol/

https://go.drugbank.com/drugs/DB00603

https://www.ncbi.nlm.nih.gov/books/NBK559192/#:~:text=The%20following%20adverse%20effects%20of,vaginal%20hemorrhage%2C%20and%20uterine%20hemorrhage.

https://www.rxlist.com/medroxyprogesterone/generic-drug.htm#:~:text=Medroxyprogesterone%20has%20no%20known%20severe,brigatinib

https://www.nursingtimes.net/clinical-archive/sexual-health/medroxyprogesterone-08-03-2005/

https://www.mayoclinic.org/drugs-supplements/medroxyprogesterone-oral-route/side-effects/drg-20146771?p=1#:~:text=It%20is%20very%20important%20that,with%20a%20patient
%20information%20leaflet.

https://www.drugs.com/drug-class/androgens-and-anabolic-steroids.html

https://www.drugs.com/pro/androgel.html

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d466910c-9a76-44e8-8759-4717ec2c591f#:~:text=INDICATIONS%20AND%20USAGE,Congenital%20or%20Acquired)%20(1.1)

https://www.centerwatch.com/directories/1067-fda-approved-drugs/listing/3141-androgel-testosterone-gel#:~:text=Mechanism%20of%20Action,testosterone%20into%20the%20systemic
%20circulation%E2%80%A6

https://www.rxlist.com/androgel-drug.htm

https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=77215d87-ad22-4169-bd5f-a453f10b21ef&type=display#:~:text=AndroGel%20can%20cause%20fetal%20harm,in
%20varying%20degrees%20of%20virilization.