C+D Conference Highlights & Pharmacy Insights
C+D Conference Highlights & Pharmacy Insights
- J
f- r
Why Nurofen Plus? If you were pain, you'd be scared too - in a pain
relief study* 72% of customers preferred ibuprofen + codeine (Nurofen Plus)
to a paracetamol + codeine + caffeine combination product.'
So give pain a fright and your pain customers what they prefer, recommend
Nurofen Plus because there's no more effective painkiller available
without prescription.
* In a dental pain study
Essential Information Nurofen Plus Tablets contains 200mg ibuprofen and 12.8mg Codeine phosphate Indications: For the short term treatment of acute, moderate pain (such as
rheumatic and muscular pain, backache, migraine, headache, neuralgia, period pain and dental pain) when other painkillers have not worked. Dosage and Administration: For oral
administration and short-term use only. Adults. 1 or 2 tablets every 4 to 6 hours. At least four hours between doses. No more than 6 capsules in any 24 hour period. Not to be taken
for more than 3 days continuously. The patient must consult a doctor if symptoms persist or worsen, or if the product is required for more than 3 days. Not to be taken less than 4
hours after taking other painkillers. The Elderly: No special dosage modifications are required for elderly patients, unless renal or hepatic function is impaired, in which case dosage
should be assessed individually. Not for use by children under 12 years of age. Contraindications: Hypersensitivity to ibuprofen or other constituent. History of hypersensitivity reactions
(e.g. asthma, rhinitis, angioedema, or urticaria) in response to aspirin or other non-steroidal anti-inflammatory drugs. History of, or existing gastrointestinal ulceration/perforation
or bleeding. Severe hepatic failure, severe renal failure or severe heart failure. In last trimester of pregnancy there is risk of premature closure of the foetal ductus arteriosus.
Onset of labour may be delayed and the duration increased with increased bleeding tendency in both mother and child. Hypersensitivity to codeine, respiratory depression, chronic
constipation Precautions and Warnings: Caution in patients with certain conditions, which may be made worse, e.g. systemic lupus erythematosus and mixed connective tissue disease,
gastrointestinal disorders and chronic inflammatory intestinal disease, hypertension and/or cardiac impairment, renal impairment, hepatic dysfunction. The elderly are at increased
risk of the consequence of adverse reactions. Bronchospasm may be precipitated in patients with bronchial asthma or allergic disease. Do not use with other NSAIDs, including COX-2
For three days use only. Can cause addiction.
NUROFCN
PLUS o
specific inhibitors. Female fertility may be impaired by a reversible effect on ovulation. Gl bleeding, ulceration or perforation Caution is required in patients on medications which
increase the risk of gastrotoxicity or bleeding. If Gl bleeding or ulceration occurs, stop treatment and refer to a doctor. If mucosal lesion, skin rash or other sign of hypersensitivity o
the treatment must be stopped. This medicine contains codeine which can cause addiction if you take it continuously for more than 3 days. If you 'or headaches
for more than 3 days it can make them worse Side Effects: Hypersensitivity reactions may include non-specific allergic reactions, anaphylaxis, 'act reactivity (e.g. asthma,
res|
bronchospasm) and various skin reactions (e.g. pruritus, urticaria, angioedema). Side effects to codeine include constipation, respiratory depression, cough suppression, nausea and
drowsiness. Regular prolonged use of codeine is known to lead to addiction and symptoms of restlessness and irritability may result when treatment is then stopped MRRP (excl VAT):
£2.36 (12 tablets) £4.44 (24 tablets) £5.28 (32 tablets) Legal Category: P. Product Licence Numbers: PL 000327/0082 Licence Holder: Crookes Healthcare Limited, Nottingham NG2 3AA.
Date of Preparation: March 2010 References 1 McQuay et al. Anaesthesia 1992;47:672-677.
Product Information. Panadol Advance 500mg Tablets. Presentation: Paracetamol 500 mg. Contains Pregnancy/lactation: Use in pregnancy should be on doctor's advice. Not contraindicated in breast feeding.
disintegrant system to accelerate dissolution. Uses: Mild analgesic and antipyretic. Headache, migraine, Side effectsThrombocytopenia. agranulocytosis, anaphylaxis, hypersensitivity including skin rash, angiodema,
tension headache, toothache, backache, rheumatic and muscle pain, dysmenorrhoea. sore throat, Steven Johnson syndrome, toxic epidermal necrolysis, bronchospasm and hepatic dysfunction.
feverishness, aches and pains of cold and flu, pain due to non-serious arthritis. Dosage and Legal category: 1 Compack GSL, 32's R Product licence number: PL 0007 /044 Product licence
6's 1
1
.
administration. Adults and children, 1 2 years and over: Two tablets up to four times daily as required. holder: GlaxoSmithKline Consumer Healthcare, Brentford, TW8 9GS, U.K. Package quantity and RSP
Max. 8 tablets in 24 hours. Children 6-12 years: Half to one tablet three or four times daily as required. (excl.VAT): 1 6's Compack £ .23. 32's £2.37. Date of last revision: June 20 0. Panadol is a trade mark
1
1
Do not use for more than 3 days without doctors advice. Children under of the GlaxoSmithKline group of companies.
Max. 4 tablets in 24 hours.
6 years Not recommended. Doses should not be repeated more frequently than every 4 hours, MP3 player supplied will differ from one shown.
Contraindications: Known hypersensitivity to ingredients. Precautions: Renal or hepatic impairment,
non-cirrhotic alcoholic liver disease. Contains parahydroxybenzoates - may cause allergic reactions. Copyright 20 1 0, GlaxoSmithKline MyPharmAssist.co.uk
Interactions: Domperidone, metoclopramide, cholestyramine, warfarin or other coumarin anticoagulants. Consumer Healthcare. All rights reserved.
5
Have your say on C+D's news. Email us at:
haveyoursay@chemistanddruggist.co.uk
Croup Editor
Gary Paragpuri MRPharmS
020 7921 8045
News Editor
Max Cosney 020 7921 8147 Three seemingly unrelated events - and the PDA couldn't have come at
Features Editor an award-winning pharmacy in a better time (p6) The existing rules
Jennifer Richardson 020 7921 8084 Orkney, the pharmacy supervision that dictate what you can and can't
Digital Content Editor rules, and the latest funding do are over 40 years old and simply
NiallHunt 020 7921 8185
announcement for England's do not fit with what's expected from
Clinical & CPD Editor
Chris Chapman 020 7921 8086 contractors - say a lot about the a modern pharmacy - either by the
Jonathan Franklin 020 7921 8333 medication or allergy history? services come and then go according
C+D Data
Devi Patel (Operations Manager)
FIND AWAY THAT Sutherland's Pharmacy's solution to PCTs' debt levels is an absurd way
seems so obvious that you wonder of incentivising pharmacy. It does
020 7921 8235
Michael Pavey (Business Development ALLOWS THEM why it isn't more widely used. little besides confirming what
Manager) 020 7921 8422 Perhaps it's because the average pharmacists already know about
Colin Simpson (Price List Controller) TO ADD REAL, pharmacy is dispensing around where PCTs' priorities lie.
020 7921 8667 5,000 items per month and because Against this background of where
Darren Larkin (Electronic Data
MEASURABLE, AND pharmacists don't fancy a criminal the sector needs to be, the news
Controller) 020 7921 8294
conviction if they make an error The that £140 million is being clawed
Mira Inameti (Data Specialist)
020 7921 8115
REIMBURSABLE end result: rather than spend more back by the Department of Health
Sandra Drawbridge (Input Clerk) time with patients, pharmacists are doesn't exactly inspire hope (p6).
020 7921 8674 PATIENT BENEFITS wedded to the final check and PSNC hopes to begin discussions
Projects Director
struggling to find a way that allows on funding reform to reward quality
Patrick Crice MRPharmS
them to add real, measurable, and and outcomes. It can't come soon
020 7921 8335
TrainingDevelopment Managers reimbursable patient benefits. enough.
SaraMudhar MRPharmS So the current focus on
020 7921 8414 supervision coming from the RPSCB Gary Paragpuri, Editor
Kinna McConochie MRPharmS
020 7921 8413
Training Sales Manager
Paul Thorp 020 7921 8426
Projects Administrator
Pauline Sanderson 020 7921 8425 6 Contractors face £140m Cat M hit 15 Update: medicines adherence
Projects Admin Assistant
LewisSwan 020 7921 8420 Convincing patients to take their medicine
7 Calls for rosiglitazone to be withdrawn
Production Controller
Christine Langford 020 7560 4133
18 Practical approach
8 Fee flouting restoration bid fails
Managing Director What might be causing a teenager's flaking rash?
Phil Johnson 020 7921 8106 10 Your guide to pharmacy PR pilots
Email 20 Platinum Design Awards
firstname. surname 12 GSK launches free pain podcast A winning redesign on remote Orkney
@ubm.com
14 Xrayserand David Reissner 23 Ten things about... neuropathic pain
Key points in light of the revised Nice guidance
25 Classified
30 Postscript
® UBM Medica. Chemist+Druggist incorporating Retail Chemist. Pharmacy Update and Beauty Counter Published Saturdays by UBM Medica. Ludgate House, 245 Blackfnars Road. London SE1 9UY. C+D online at:
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11.09.10 5
Contractors facing category M
hit of £140m under funding deal
Prepare for clawbacks now, warns PSNC chief, as individual pharmacies face £1 3,000 cost
Chris Chapman
chris.chapman@ubm.com
£2.49 billion. This is an increase of contractors to prepare for this now." "That's a member of staff. And why? PSNC said the results of its cost of
around £170m on the £2.32bn sum However, contractors were Because we're buying better than service inquiry would not be known
agreed for 2009-10. fortunate the clawbacks were spread [the government] thinks we can." for "several weeks".
PSNC chief executive Sue Sharpe out, and not combined into a shorter Independent Pharmacy However, Earl Howe has agreed to
warned contractors to prepare now timeframe, Mrs Sharpe said. Federation chair Fin McCaul, called reserve £250m, a proportion of
for the financial loss. PSNC was expecting to discuss for an overhaul of the contract to which will be held as a risk share, in
She said: "Contractors will no funding reforms with the alleviate the problems. "We're stuck the event the inquiry shows
doubt feel the effects of excess Department of Health in the near in swings and roundabouts, so there underfunding for the sector, the
margin recovery when January future to reward quality and is no confidence in the business and negotiating body added.
clause in their new health bill this "Discussions over the autumn will to remove the pharmacist from the "Remote access is a problem, the
autumn do as we asked."
to need to take account of the wider scene. As a clinician I am not willing area I cover has an area of 12,500
However, it remains unclear how work of the review to ensure that the to do that. square miles. Many patients have no
quickly any change to the law will overall approach taken is coherent." "You can't say you can be out of access to community pharmacy."
arrive. The MHRA told C+D this July Ms Gordon's comments came in the pharmacy for two hours as you Debate attendees also questioned
that any changes to the Medicines her first public speech as Society don't know what's going to happen how the RPS will engage members
Act made before its 2012 review chief executive. HF in those two hours." in the supervision consultation. HF
S 11.09.10
Become an MUR master. Register for a C+D training course at
www.chemistanddruggist.co.uk/stafftraining
"the risks of rosiglitazone outweigh healthcare professionals on scheduled for September 23. www.chemistanddruggist.co.
its benefits and it no longer has a cardiovascular restrictions and Currently, the EMEA advises uk/thepharmacyshow
healthcare professionals "to strictly
Quiz the RPSGB boss
Pharmacist meds management can stop follow the current restrictions in the
product information" when C+D is offering two pharmacists
nine in 10 care home errors, trial reports prescribing the drug. an opportunity to interview
Pharmacists can cut care home Internal medicines errors such as GlaxoSmithKline, which Society chief Helen Gordon. To
medication errors by 91 per cent if changes in dose, medication or out manufactures rosiglitazone under enter simply email your top five
given full responsibility for of date records were reduced from the brand Avandia, refuted the questions for the new RPSGB boss
medicines management, a trial 69 at baseline to only six during the claims there was a lack of to gary.paragpuri@ubm.com
scheme has found. trial period. safety data on the drug, and
The four-month trial, by The trial follows an alert from urged patients who may have NCSO endorsements
Midhurst Pharmacy in London, the Department of Health in concerns to discuss treatment The following are allowed NCSO
introduced an intensive January, warning that older people with their GP. endorsements for September
pharmacist-led pharmaceutical in care homes were exposed to a "We continue to believe that prescriptions in England and
intervention programme at a 69- higher rate of medication errors Avandia is safe and effective when it Wales: dexamfetamine 5mg
bed higher-dependence care home. than those in the community. EJ is prescribed appropriately," the tablets, gabapentin lOOmg and
manufacturer added. 300mg capsules, and ofloxacin
400mg tablets.
added to how biggest health worry for over half of the population. Boots staff will also raise
scary the robbery was More on these stories online
funds for Macmillan, aiming to clock up 290,000 miles - one for every person
as you can't read their facial www.chemistanddruggist.co.uk
diagnosed with cancer in the UK each year MC
expressions." HF
1 1.09.10 7
Pharmacist investigated for CPD breaches
NEWS www.chemistanddruggist.co.uk/news
Dispensary
p harmadst who floute<J
Did you get a longer
break over the bank
fees fails restoration bid
holiday or did you work? Applicant must wait further six months to re-apply, says committee
A pharmacist who continued to 2009, despite being removed from that he had no money to pay the
"I took a practice despite failing to pay his the register for non-payment of fees. retention fee in June 2009.
longer break retention fee has failed in a bid to be During the locum shifts he had Mr Johnston was fully aware of
and went to restored to the register dispensed, on one occasion, schedule the implications for him after his
Spain with the Damien Johnston, of Belfast, had 2 controlled drugs, the committee name was removed from the
kids over the committed a serious abuse, a heard. register, the committee was told
bank holiday, Northern Ireland statutory Mr Johnston deliberately misled The statutory committee
as they were committee hearing ruled. his employer about his unregistered acknowledged Mr Johnston's full
off." He had flouted a registration status, the hearing was told. acceptance of the facts and his
Culab process that assured the public that Authorities were alerted after a otherwise unblemished record.
Chauhan, those acting as pharmacists were pharmacy annual return showed he Mr Ferris said his removal should
Malvern Pharmacies Croup, properly accredited, the committee had been employed as a locum. not be forever and he could re-apply
Malvern chairman Tim Ferris said. Mr Johnston fully accepted he had in six months. The verdict came as
Mr Johnston worked as a acted in a way that constituted PSNI removed 18 pharmacists from
"I usually pharmacist on seven occasions misconduct at the hearing. the register this September for
don't work between September and December He offered no defence other than failing to pay fees. Contrib
Mondays and
only work four
days a week. Clinical debate C+D's Chris Chapman looks at the evidence behind the headlines
However, we
have a
rota for bank
holidays and
shift
I
How to prove you're competent
had to work Healthcare Council. This includes the pharmacy world, too. Only
on the Monday last week. So I anyone providing aromatherapy and pharmacists who decide to join
actually worked longer hours!" reflexology, and will soon include the professional leadership body
Rachna Chhatralia, Day Lewis, acupuncture and general 'healing'. will have the post-nominal
Wellington, Surrey Former health minister Andy MRPharmS to show patients as
Burnham argued for the move, added 'proof. But it's not a legal
recognising that herbal remedies are requirement to join the new
Yes, I took a longer break 54% but without the full trappings of competence. It's the GPhC
professional recognition". registration that matters to
bank holidays according to this answer is simple: you have an And as charity Sense About Science, competency for providing
week's C+D survey. Only 54 per cent easily checkable registration which this week demonstrated evidence-based healthcare.
of respondents reported taking a number. But, actually, it doesn't against the suggestion outside the A register of complementary
longer break over the August bank mean a thing. Department of Health, points out, a therapists would only add
holiday weekend. In April, the previous member of the public won't know confusion to an already mudded
Next week's question: government made tentative plans the difference between a recognised picture, and potentially be to the
As the RPSGB prepares to relaunch to ensure all practitioners of health professional and someone detriment of patients.
as a new-look leadership body, we complementary therapy must registered to provide a
ask, does the Society deserve a be registered with the complementary therapy. Chat with Chris on Twitter:
second chance? Vote at Complementary and Natural There are added complications in www.twitter.com/CandDChris
www.chemistanddruggist.co.uk
new "Diarrhoea dialogue" initiative has been designed to support you through those awkward conversations,
providing you with the tools to help offer your customers the advice they need.
Imodium
PLUS CQPL£TS
Loperamide hydrochloride
& Simeticone
6
The 2008 white paper promised a remedy with a PR campaign for the sector. Four PCTs have
been given £1 52,000 to pilot the initiative. Hannah Flynn checks on their progress so far
Location:
South West Location: PCTVERDICT:
Essex PCT North Yorkshire "We hope this project will shed new light on the
and York PCT reasons why men in this age bracket don't use
The campaign:
community pharmacies to their fullest potential. By
The PCT aims to The campaign:
taking a social marketing approach to this project, we
work with The PCT plans
hope to uncover men's perceptions towards community
community to increase the
pharmacy, the barriers that prevent them using
pharmacists number of
pharmacy and explore ways to remove these barriers.
to reduce 45 to 55-year-old
"Preliminary engagement with pharmacy staff in the
cardiovascular males accessing
Scarborough area has already revealed some
disease among pharmacy advice
interesting insight. One area we are planning to
disadvantaged and services
PCT VERDICT: explore further is the role that partners play in
residents
"NHS South West Essex believes that community Budget: influencing the health of men. We are also exploring
Budget: pharmacists can play an increasing role in improving £40,000 aspects such as accessibility and the perception that
£37,000 access to health services as they are conveniently pharmacy could be seen as a more female-friendly
located within communities and often have extended
How have they environment."
How have they opening hours, making it easier for workers to access
promoted PHARMACIST VERDICT:
promoted this service.
pharmacy? "The campaign will help as it offers a whole package to
pharmacy? "After a successful pilot, involving20 pharmacies
Local newspapers
our customers, and encourages people from all
An integrated and community
in Basildon and Tilbury, NHS South West Essex is avenues of life to come
The 45 to 55 age group
in.
social marketing networks and
refining the service. The PCT worked closely with traditionally under-attends and this campaign will give
campaign clubs
participating pharmacists to help them introduce the us another group to work with. It is incredibly
Planned service, and by training counter staff. However, where Planned satisfying as a pharmacist to be able to engage in
J
launch: pharmacists have underperformed, the testing kit launch: health prevention with an individual before they come
Late 2010 will be reallocated to pharmacists in Grays, an area of November 2010 in with a health issue."
high deprivation." Sandra Hutchinson, Boots Pharmacy, Scarborough
I
Trade up tjour customers to
Pessary Intern. 1
( ream
3w
For more information on the Canesten range please visit the Canesten website at
www.canesten.co.uk/hcp C gyi24 j une 2010
Check what's on TV this week
PRODUCT NEWS www.chemistanddruggist.co.uk/prodnews
Rt ecu mill;
GSK launches free pain podcast
Should homeopathic GSK Healthcare has launched a
podcast to assist pharmacists and Market focus
remedies be labelled pharmacy assistants in pain
consultations.
'placebos'? • £21 1m- total adult
The free 10-minute podcast will
analgesics value.
be delivered by the Panadol brand
"I don't think and offers interviews and case
• 3 per cent - increase in the
we should studies for pharmacy teams to use
total adult oral analgesics
label them as training to improve their pain
market in 2009.
as placebos consultations.
as these The 10 Minute Pain Podcast is
Source: Kantar WorldPanel value sales
products are delivered in a disposable MP3 player, 52 weeks to November 29, 2009
marketed as says GSK Healthcare.
containing The free podcasts will be available
small upon request through trade GSK Healthcare
amounts of advertising, direct-mailed reply paid Tel: 0800 783 3927
medicines, so if we label them as on GSK's pharmacy
cards, www.mypharmassist.co.uk - or by www.mypharmassist.co.uk
placebos that is misleading." community website - calling 0800 783 3927. ukpharmassistteam@gsk.com
Bhavesh Patel, Pharma
Healthcare, Canvey Island, Essex
ICaps website supplemented with new advice
"Labelling
them Alcon has updated the The website also contains
placebos may website of its eye product and stockist
encourage supplement product ICaps. information, according to the
misuse, as The consumer website company.
they do has been designed to offer It can be accessed at:
download
also possible to
free display
formulation containing dry extract
of the herb valerian.
General
Pharmaceutical
Check your mail for your
Council GPhC information pack!
12 11.09.10
Fluoride Mouthrinse Winter needn't
- The Evidence be woeful
Our oral health as a nation has
daily use have been shown to reduce tooth decay significantly in the the importance of marketing the service to push this out to
permanent teeth of children over 6 years and adolescents. your communities with added gusto. Recent figures released
by Novartis Vaccines, our partner in delivering the flu
• Fluoride mouthrinses, in addition to daily use of fluoride toothpaste, are
vaccination service, demonstrate that 90 per cent of patients
also beneficial to adults and the elderly.
receiving the flu vaccination in a pharmacy would return for
• Ideally mouthrinses should be used at a different time of day to twice further vaccinations they were made available.
if
daily toothbrushing with fluoride toothpaste to maximise the benefit of However, the good work that you all do to promote
additional fluoride.
the service has been highlighted superbly by the 37 per
cent who said that they only had the flu jab because the
The Department of Health publication: 'Delivering Better Oral Health - pharmacy was promoting it.
2
An Evidence-based toolkit for prevention' includes guidance to dental Evidence indeed that good marketing works well and this
professionals on prescribing a daily fluoride rinse containing is an ideal time to sing about the service and its convenience
0.05% fluoride (225ppm F) as a way of increasing fluoride availability to to customers both loyal and new.
prevent caries. Accompanying the impending flu season will be the fourth
issue of our All About Health magazine. Judging by the
Colgate FluoriGard fluoride mouthrinses contain 0.05% fluoride (225ppm).
requests that we get to fulfil additional orders with you, this is
Colgate FluoriGard Daily rinse is clinically proven to reduce caries.' Colgate
clearly going down a treat with your customers.
FluoriGard Alcohol Free rinse offers fluoride protection in a formulation that
This issue brings more celebrity health secrets from
does not contain alcohol, making it ideal for patients who may prefer to
Ben Fogle and former spice girl turned TV hostess Emma
choose an alcohol free option.
Bunton. It also features a winter colds special to coincide
Co All About
What do you think?
OPINION haveyoursay@chemistanddruggist.co.uk
with PCTs, and replace them with CP going to assess the value of their service provision
commissioning groups. Suddenly the whole and thus the value of their business. So when your
premise changes again as interpretation of the PCT asks for contribution make sure you respond,
in
and
many
I'd bet that the
cases will be that the
because if you think you're the only interested
party - well, dream on!
WERE: 'WE WILL HAVE A greatest need for pharmacy services could be
within any number of CP practices. "Oh no," hear I What's happening with the PNA
PHARMACY, WHATEVER you cry, "of course that won't happen..."
in your area?
Since owning Xrayser pharmacy, have been I
full and accurate records of the to explain what the standards mean on the shoulders of pharmacist
professional services they provide. I when they say that, in addition to owners and superintendents.
realise that dispensing is invariably cases where they have consent or I wonder if the CPhC recognises
recorded in the PMR (although I are required by law, they may only the practical difficulties in
sometimes see problems because disclose confidential information in maintaining a retrievable record of
the date of dispensing is not "exceptional circumstances". which pharmacist checked every
"I FORESEE SOME
necessarily the date of supply to a RPSCB standards required single prescription. Superintendents
patient). There is a reason to pharmacists in positions of authority can put systems in place, but it
REQUIREMENTS
document when payment - including responsible pharmacists
services
- to ensure there
should be up to the responsible
WILL CAUSE TENSION
depends on having a record. But do is a retrievable pharmacist to implement them.
all pharmacists record the advice record of the pharmacist taking David Reissner is a specialist in
IN THE WORKPLACE,
they give, or when unwanted responsibility for the provision of pharmacy law and head of
medicines are received for disposal? each pharmacy service. This has healthcare at Charles Russell LLP HOWEVER HIGH-
I foresee some requirements will caused difficulties when an error is (www.charlesrussell.co.uk/
cause tension in the workplace, made and no one can identify which pharmacy). Contact him on 0207 MINDED THE
however high-minded the principle. pharmacist was responsible 203 5065 or email david.reissner@
For example, pharmacists have an The Society was never able to charlesrussell.co.uk PRINCIPLE"
14 Chemist 11.09.10
CLINICAL CLINICAL BUblNtbb CLINICAL
Medicines adherence
How pharmacists can convince patients they need to take their medicine
Parastou Donyai PhD, MRPharmS effective for all patients, conditions and settings
Comprehensive interventions, combining
Adherence is the extent to which patient asking patients specific questions about
Factors that affect adherence include behaviour matches the recommendations of a adherence
healthcare provider. A distinction is often made i following patients up, building a partnership
social and economic factors, lack of
between intentional and unintentional non- being warm and empathetic and providing
knowledge from healthcare team members, adherence. 12 With intentional non-adherence, emotional support.
condition-related factors, therapy-related the patient has decided not to follow the Behavioural science also offers useful theories,
recommendations, whereas with unintentional models and strategies for impacting on patient
factors and patient-related factors. These
non-adherence the patient either forgets and/or is behaviour. Research focused on changing patients'
factors are complex so no single not paying attention. Sometimes both elements attitudes and behaviour has shown the following
intervention is suitable for all patients. may be at play. can work:
• promoting self-care and enhancing patient
Tackling deliberate non-adherence could Adherence factors responsibility
involve discussing patient beliefs, while Non-adherence to medicines is a problem e increasing concern about the consequences of
forgetful patients may benefit from worldwide. The World Health Organization the disease without treatment
(WHO) published a comprehensive report on • enhancing the perceived value or confidence of
reminder technology.
medicines adherence in 2003 that outlined why treatment
patients fail to take their medicines and provided • providing clear patient instructions - start early,
some possible solutions. 3 ideally when a new treatment is prescribed.
at techniques can I use? Adherence is affected by the interaction of five For therapy-related factors, pharmacists should:
key dimensions: • educate the patient about their medications and
g techniques can improve "
social and economic factors - eg poverty, the conditions for which they are prescribed
cordance. These include weighing pros illiteracy, access to healthcare and medicines, i review the patient's medication history
id cons and encouraging patients to effective social support networks, cultural beliefs • continuously monitor the patient's therapy
about illness and treatment • screen for potential adverse effects
step into the role of others affected by
healthcare team and system-related factors - « monitor the patient's ability to take their
ir treatment. eg lack of knowledge, lack of tools, poor medications correctly and to adhere to the
communication prescribed therapies.
5 condition-related factors - eg depression has a In 2008, researchers in Denmark published a
et Update emailed to you each week, considerable effect on adherence generic adherence programme to help improve
ister for C+D's CPD newsletter at • therapy-related factors - eg the dose frequency patients' chronic medication use. Taking the WHO
www.chemistanddruggist.co.uk/register and the incidence of side effects recommendations, they produced an
» patient-related factors - eg lack of information individualised, multi-dimensional adherence
and skills, difficulty with motivation and self- counselling programme. 4
efficacy, and lack of support for behavioural The process of the intervention was summarised
Supported by
changes. in the following short formula: "Find the patient,
As these factors are complex, no single get the story, check for errors, find the resources
GENUS PHARMACEUTICALS
intervention or package of interventions is together with the patient, share goals, agree
11.09.10 15
ZONE V 15 Medicines adherence ^ 18 Seborrhoeic dermatitis ^ 20 Sutherland's Pharmacy 23 Neuropathic pain
on plan, get it done and follow up". According to the researchers, intentionally non- studies exists, the inconclusive nature of the
The model begins by allowing patients to talk adherent patients have typically made their evidence means there is no definitive best practice
about their medication use. The idea is that letting decisions based on several subjective feelings and advice. Complex interventions that take account of
patients tell their story helps pharmacists identify experiences (eg misunderstandings, negative individual patient situations combined with
key issues and then helps the patient create a more feelings, lack of support, lack of confidence in the enhanced delivery/communication skills might
suitable version of the story, with the right healthcare system and personnel, lack of work in some cases, where story telling and
resources and solutions. In this next stage of the confidence in medications, low self-esteem, bad discovering patient resources could lead to an
model the pharmacist uses 'coaching' techniques, experiences). With unintentional non-adherence, agreed action plan and further follow-up.
in effect asking a series of questions to help the forgetfulness is often the problem and the patient References are online in the full version of this
patient realise the answers for themselves. may only need help for the execution of the article at www.chemistanddruggist.co.uk/update
Patients can choose from among the solutions treatment - hence packaging and reminder
they have come up with during the session, based technologies may be helpful. Therefore very Parastou Donyai is a lecturer in pharmacy
on what they feel capable of implementing in their different approaches are needed to improve practice at the University of Reading
own lives. Thus the coaching process is ultimately a adherence depending on the patient's type of Download a CPD log sheet that helps you
means of creating a concordant partnership non-adherence. complete your CPD entry when you
between the patient and the pharmacist. See table Helping patients with adherence is not a successfully complete the 5 Minute Test for
1, below, for the model's coaching questions. straightforward task. Although a plethora of this Update article online (p17).
treatment? her deteriorating asthma and suspected non- Once Alma understood the importance of not
Would he be satisfied? adherence. She is prescribed a salbutamol and a missing doses, she faced a behavioural problem,
What would he think should be done? beclomethasone inhaler. namely the need to have access to her
If we asked your family/network, what Alma seems motivated, knows the medication when she was away. Alma would
would they say? importance of taking her medication and have been asked coaching questions by the
Are they worried about your condition? considers herself adherent, but forgets to use pharmacist to pick up on her own version of the
© Do they have wishes or suggestions that her steroid inhaler when her routine is story, as well as questions that made her step
you often hear? interrupted by her grandchildren's schedule. into the role of others - what would her
The pharmacist believes Alma's patient daughter want her to do and what would her
Weighing pros and cons medication record indicates under-use. Alma grandchildren want to see?
How do the 'errors' you make today says she uses her inhaler as planned but says The coaching questions would have also
benefit you? "of course slips and lapses happen when your identified Alma's willingness to take control of
What are the disadvantages? attention is elsewhere, but is there really much monitoring her peak expiratory flow rate. So in
On a scale from 0-10, how do you rate the harm in Alma believes
missing a few doses?" summary, rather than a simplistic model, the
importance of, for example, improving your that these lapses could not really make a patient has been listened to in order to find the
peak expiratory flow rate? difference, but also knows that her wheezing has right tools for her individual case.
www.chemistanddruggist.co.uk/register
Medicines adherence
http://www.npci.org.uk/lift/lift.php, which includes be able to download a CPD log sheet that helps you complete your CPD
information, quizzes and case studies. entryatuptodate.org.uk V-'-HV" vi^V/'
lytol, Nytol One-A-Night Good Mornings Follow a Good Nytol are registered trade marks of the
CLINICAL
tacrolimus
ADVAGRAF
tacrolimus prolonged release
Practical Approach
What is my
Presentations: Advagraf Prolonged -release hard capsules containing risk factors for these conditions include pre-existing heart disease,
3mg and mg
son's
tacrolimus 5 mg, 1 mg, 5 Program hard capsules corticosteroid usage, hypertension, renal or hepatic dysfunction,
containing tacrolimus 0.5 mg, 1 mg and 5 mg Indications: Advagraf infections, fluid overioad, and oedema. Patients are at increased nsk of
and Prograf: Prophylaxis ot transplant rejection in adult liver or kidney all opportunistic infections including BK Virus associated nephropathy
allograft recipients and treatment ot allograft rejection resistant to and JC Virus associated progressive multifocal leukoencephalopathy
treatment wrth other immunosuppressive medicinal products Posology Physicians should consider this in their differential diagnosis in
Patients
with
have
deteriorating
been
syndrome (PRES).
renal
reported
It
function
to develop
so radiological
or
initiated, by physicians experienced in immunosuppressive therapy and tests should be performed. If PRES is diagnosed, adequate blood
and how effective are they the management ot transplant patients Dosage recommendations pressure and seizure control and immediate discontinuation of
given below should be used as a guideline Advagraf or Prograf are tacrolimus advised Echocardiography or ECG monitoring pre-and
considered to be? routinely administered in conjunction with other immunosuppressive post -transplant
is
3. What prescription treatments agents in the initial post-operative period The dose may vary depending and or a change of immunosuppressive agent should be considered if
on the immunosuppressive regimen chosen Dosing should be based on abnormalities develop Tacrolimus may prolong the OT interval Exercise
are used for this condition? clinical assessments of rejection and tolerability aided by blood level caution in patients with diagnosed or suspected Congenital Long QT
4. What other therapies are monitoring. To suppress graft rejection immunosuppression must be
Concomitant use
limit to reported ot other immunosuppressives such as
used? daily dose of Advagraf capsules should be taken once daily in the antilymphocytic antibodies increases the risk of EBV-associated
morning with water at least 1 hour before or 2-3 hours after a meal. lymphoprolrferative disorders. EBV-VCA negative patients have been
Prograf capsules should be taken as for Advagraf in two divided doses reported to have increased risk ot lymphDproliferabve disorders. EBV-
Advagraf In stable patients converted from Prograf (twice daily) to VCA serology should be ascertained before starting tacrolimus
Advagraf (once daily) on a 11 (mgmg) total daily dose basis the treatment During treatment, careful monitoring with EBV-PCR is
1. Seborrhoeic dermatitis. The cause systemic exposure to tacrolimus for Advagraf was approximately 10% recommended Exposure to sunlight and UV light should be limited. The
lower than for Prograf The relationship between tacrolimus trough secondary cancer unknown Dose may be necessary
is unknown, but it is thought to be risk of is reduction
trough levels should be measured before and within two weeks after hypersensitive to peanut or soya, the nsk and seventy of hypersensitivity
Malassezia furfur. This may be a conversion In de novo kidney and liver transplant patients AUC,,., of should be weighted against the benefit of using Advagraf capsules
normal commensal, but tacrolimus for Advagraf on Day was 30% and 50% lower respectively, contain lactose Interactions: See SPC Pregnancy and lactation:
skin 1
when compared with that for Prograf at equivalent doses. By Day 4, Tacrolimus can be considered in pregnant women when there is no
patients with the condition may systemic exposure as measured by trough levels is similar for both safer alternative See SPC Undesirable effects: Medication errors have
kidney and liver transplant patients with both formulations Race: In been observed A number ot associated cases of transplant rejection
have reduced resistance to it.
comparison to Caucasians, Afro-Caribbean patients may require higher have been reported (frequency cannot be estimated from the available
2. Ketoconazole 2 per cent shampoo. tacrolimus doses to achieve similar trough levels Prophylaxis of data) Many of the following adverse drug reactions are reversible and/
transplant [election - liver and kidney Initial dose of Advagraf and or respond to dose reduction. Very Common (>1/10): Hyperglycaemic
Several studies have validated its Prograf capsules is 10-0 20 mg/kg/day for liver transplantation and conditions, diabetes mellitus, hyperkalemia, insomnia, tremor,
A woman comes into the Update efficacy for dandruff and seborrhoeic 20-0 30 mg/kg/day for kidney transplantation starting approximately headache, hypertension, diarrhoea, nausea, renal impairment,
12-18 hours for Advagraf and 1 2hrs tor Prograf after completion of liver infections, liver function test abnormal, Common (>1/10Q to <1/10):
Pharmacy trailing a reluctant dermatitis of the scalp. or within 24 hours of completion of kidney transplant surgery. Dose haematological abnormalities, hypomagnesaemia, hypophosphataemia,
adjustment post -transplant Advagraf and Prograt doses are usually hypokalemia, hypocalcaemia, hyponatremia, fluid overload,
young teenage boy behind her. She '
Pyrithione zinc. Available mainly reduced in the post-transplant period It is possible in some cases to hyperuncaemia, appetite decreased, anorexia, metabolic acidoses,
asks to speak to the pharmacist, as 'medicated' shampoos that are withdraw concomitant immunosuppressive therapy leading to Advagraf hyperlipidaemia, hypercholesterolemia, hypertngiycendaemia, anxiety
monotherapy or Prograf dual therapy or monotherapy Post -transplant symptoms, mental disorders, confusion and disorientation, depression,
David Spencer. not licensed as medicines. It has improvement in the condition of the patient may alter the mood disorders and disturbances, nightmare, hallucination, seizures,
pharmacokinetics tacrolimus and may necessitate further dose disturbances consciousness, paresthesias and dysaesthesias,
"I wanted to take Kevin to the produced inferior results to
ot in
adjustments Dose recommendations - Conversion to Advagraf, Patients peripheral neuropathies, dizziness, wnhng impaired, vision blurred,
doctor," the woman says when ketoconazole. maintained on twice daily Prograf requiring conversion to once daily photophobia, eye disorders, tinnitus, ischaemic coronary artery
Advagraf should be converted on a 1:1 (mg:mg) total daily dose basis. disorders, tachycardia, haemorrhage, thromboembolic and ischaemic
David comes out to see her. "He e Selenium sulphide shampoo. It
Following conversion, tacrolimus trough levels should be monitored and events, vascular hypotensive disorders, peripheral vascular disorders,
converting patients trom ciclosponn-based to tacrohmus-based therapy. cough, nasal congestion and inflammations, gastrointestinal
persuade him to come here." less well tolerated and less pleasant Initiate Advagraf after considering ciclosponn blood concentrations and inflammatory conditions, gastrointestinal ulceration and perforation,
clinical condition of patient Delay dosing in presence of elevated gastrointestinal haemorrhages, stomatitis, ascites, vomiting,
"What's the problem, Kevin?" to use.
ciclosponn blood levels Monitor ciclosponn blood levels following gastrointestinal and abdominal pains, constipation, flatulence, bloating
David asks, turning to the boy. Coal tar. This has been shown to conversion Dose recomm endations- Rejection therapy For conversion and distension, loose stools, bile duct disorders, hepatic enzymes and
of kidney and liver recipients from other immunosuppressants to once function abnormalities, cholestasis and jaundice, hepatocellular damage
"Nothing much, just dandruff," be significantly more effective than daily Advagraf, begin with the respective initial dose recommended for and hepatitis, cholangitis, pruntus, fash, alopecias, acne, sweating
increased, arthralgia, muscle cramps, limb and back pain, renal failure,
Kevin replies. placebo. It is available as shampoos rejection prophylaxis. In adult heart transplant recipients converted to
Advagraf, an initial oral dose of 1 5 mg/kg/day should be administered oliguria, renal tubular necrosis, nephropathy toxic, bladder and urethral
"It's more than that," his mother and an ointment (which also once daily in the morning For other allografts, see SPC. Dose symptoms, asthenic conditions, febrile disorders, oedema, blood
adjustments in specific populations: See SPC Target whole blood trough alkaline phosphatase increased, weight increased, body temperature
interjects. "It's quite nasty, flaking contains salicylic acid). concentration recommendations: Blood trough levels lor Advagraf perception disturbed, pnmary graft dysfunction Uncommon (>1/1000
And it's spreading down his face - Salicylic acid. It has a keratolytic should be drawn approximately 24 hours post-dosing, just prior to the to < 1/1 00). coagulopathies, coagulation and bleeding analyses
next dose, for Prograf approximately 12 hours post-dosing Frequent abnormal, pancytopenia, hypoproteinaemia, hyperphosphataemia,
look." She points to red scaly effect, but in shampoos it may be trough level monitoring in the first two weeks post-transplant is hypoglycaemia, coma, central nervous system haemorrhages and
recommended, with periodic monitoring during maintenance therapy. cerebrovascular accidents, paralysis and paresis, encephalopathy,
patches around the boy's eyebrows too dilute and have insufficient
Monitoring is also recommended following conversion from Prograf to speech and language disorders, amnesia, cataract, arrhythmias, cardiac
and bridge of his nose. contact time to be effective. Advagraf, dose adjustment, changes in the immunosuppressive arrest, heart failures, cardiomyopathies, infarction, deep venous
regimen, or co-admimstration ot substances which may alter tacrolimus thrombosis, shock, respiratory failures, respiratory tract disorders,
David asks: "Does it hurt or itch, 3. Topical: hydrocortisone and other whole blood concentrations (see 'Warnings and Precautions' and asthma, paralytic ileus, peritonitis, acute and chronic pancreatitis,
may take several days before steady stale is achieved. Most patients disorder, multi-organ failure. Rare l>1/10.000 to<1/1000): thrombotic
the doctor?" available without prescription, alone can be managed successfully if tacrolimus blood concentrations are thrombocytopenic purpura, blindness, neurosensory deafness,
maintained below 20 ng/mL In clinical practice, whole blood trough pericardial effusion, acute respiratory distress syndrome, subileus,
"It itches a bit sometimes. But and in combination with miconazole, levels have been 5-20 ng/mL in liver transplant recipients and pancreatic pseudocyst, hepatic artery thrombosis, venoocclusive liver
it's nothing much, it'll probably just which has been found effective for 10-20 ng/mL in kidney transplant recipients early post-transplant, and disease, toxic epidermal necrolysis (Lyell's syndrome). Very rare
5-15 ng/mL during maintenance therapy Contraindications: (<1/10.00Q including isolated reports!: hepatic failure, Stevens Johnson
go away soon. It's not worth seborrhoeic dermatitis, but licensing Hypersensitivity to tacrolimus or other macrolides or any excipient. syndrome, nephropathy, cystitis haemorrhagic, Neoplasms. Con sult ff|e
Warnings and Precautions: Medication errors, including inadvertent, SPC complete information on side effects and prescribing
hanging around in the doctor's," conditions prohibit use on the face); for full
unintentional or unsupervised substitution of immediate or prolonged- information. Package Quantities, Basic NHS cost & Product licence
Kevin replies. metronidazole gel, tacrolimus release tacrolimus lormulations, have been observed. This has led to numbers: Advagraf/Prograf: 0.5 mg capsules x 50 = £35.79
serious adverse events, including graft rejection, or other side effects (EU/1/07/387/002)/£61.88 (PL 00166/0206). respectively. 1 mg
The mother interrupts again: ointment. which could be a consequence of either under- or over-exposure to capsules X 50 = £71.59 (EU/1/07/387/004)/£80.28 (PL 00166/0203),
"Mr Spencer, do you know what it • Systemic: oral antifungals tacrolimus Patients should be maintained on a single formulation ot respectively. 1 mg capsules x 100 = £143 17 (EU/1/07/387/006)/£160.54
tacrolimus with the corresponding daily dosing regimen; alterations in (PL 00166/0203), respectively. 5 mg capsules x 50 = £266.92
is, and do you have anything to get terbinafine, fluconazole, formulation or regimen should only take place under the close (EU/1/07/387/008)/£296.58 (PL 00166/0204), respectively. Advagraf
supervision of a transplant specialist Advagrat only limited experience 3 mg capsules x 50 = £214 76 (EU/1/07/387/01 2). Legal Classification:
rid of it?" itraconazole, ketoconazole.
in non-Caucasian patients and those at elevated immunological risk. POM Date ol Revision: May 2010. Further information available from
"Well, Mrs Evans," David replies, 4. Phototherapy: UV light. Patients Advagraf is not recommended for use in children below 18 years due to Astellas Pharma Ltd, Lovert House, Lovett Road, Staines TW18 3AZ.
limited data on safety and efficacy Advagraf and Prograf: During initial Advagraf and Prograf are registered trade marks. For medical
"I think I know what it is and there often experience improvement period routinely monitor blood pressure, ECG, neurological and visual Information phone 0800 783 5018
are several things available without during the summer, and treatment status, fasting blood glucose, electrolytes (particularly potassium), liver
Oiiestio'fis
For more Practical Approach
1. What is Kevin likely to be
scenarios, go to www.chemist '
NHS Blood and Transplant, August 2009. NHS Transplant
suffering and what is the cause?
anddruggist.co.uk/practical Activity in the UK, 2008-2009.
2. What treatments are approach
t www kidney.org.uk June 2010.
astellas
available without prescription. Job code PRG10028UK Date of preparation June 2010 Leading Lighi for Life
18 Chemist+Druggist 11.09.10
I was one of 1190 people waiting for a kidney*
5 years waiting
12 hours of dialysis a week'
raf
tacrolimus
» ADVAGRAF
tacrolimus prolonged release
astellas
Leading Light for Life
Design
lUTA
Design
The pharmacy
factfile Design
Sutherland's Pharmacy, Kirkwall, Orkney
With shop
its two entrances and roomy
floor, the first thing that hits
site and then transported
over a seven-day period.
it to Orkney to be fitted
appear to have phased him. "The only difference "We were very keen to have electric doors as
£428,000, including robot was the cost of importing the supplies," he says. there is a lot of evidence there is better customer
The prize-winning shop was designed by flow with electric doors and it helps people
Anderson Retail Consultants, after Mr Clyde saw with prams, wheelchairs and buggies, and things
Second place, C+D Platinum Design Awards the work they had done for a previous Platinum like that."
2010, and a cheque for £2,000 Design Awards winner. According to Mr Clyde, The rear car park contains a buzzer that
they manufactured the entire shop interior off- disabled customers can use to alert staff when
ESSENT,AL L ,NKU
PGRAOe .
NATIONAL PROGRAM
nam*
they arrive. They can also speak to staff in the quickly as possible and more are now on the shop He also feels the customers benefit from the
dispensary via the system. floor, he says. greater amount of interaction with the staff they
"We did this for disabled access, and to show "It is more like the European style and saves a now have because of the introduction of the
we were thinking about all of our customers," Mr lot of staff time so you don't have two staff out dispensing robot.
Clyde says. the back doing prescriptions and then staff out He says: "It is more direct. We are speaking
"I guess you could call it a 'drive-through' front doing the serving directly to the customers and this feels better and
pharmacy as they can press the button and we "When someone comes in with an acute script more natural doing that. There is no 'please tell
can come and serve them." we literally scan it, the robot finds it instantly and Mrs Jones to take her tablets at night'. No, you just
He adds it is also used by parents with ill by the time you have done the label the [product] tell her yourself, so that is a definite advantage."
children who don't want to leave them in the car is there and you can serve somebody in under one
while they get prescriptions, so staff will also minute. It is almost too quick! Sometimes you Design for the future
leliver medicines to them in the car park. want people to go away and shop. It is extremely Aware the chronic medication service (CMS) was
quick for walk-in scripts." soon to be introduced in Scotland, Mr
European-style dispensing
In the shop itself he had further plans to radically
overhaul the way the staff did business. One Watch our interview with contractor Torquil Clyde
objective was to integrate pharmacy and retail
and hear more about how his award-winning
staff and make the whole dispensary more
customer-facing. Mr Clyde also wanted to make design was planned and executed on Orkney
the dispensing process more efficient.
The introduction of the dispensing robot has www.chemistanddruggist.co.uk
allowed staff to focus on serving customers as
From the moment your pharmacy is connected to our enhanced, intuitive PMR system with its future-proof design, you
are connected to a better future. So, with the demands being made on you by the current National Programmes, get better
connected today. Call your ProScript LINK Account Manager, email proscriptlink@aah.co.uk or visit www.aah.co.uk.
ADY'
C
0NNECTINGY0Ul0^™»«fPrO LINK ONLY FROM
AAH
CLINICAL CLINICAL
The robot has made it possible to serve some customers in less than a minute, says Torquil Clyde
Clyde was keen the design would facilitate easy "Having our computers, which are Positive
incorporation of services. The pharmacy has Solution computers, we find having the tills and
several large consultation rooms but has also the PMR as one system means you can swap
incorporated plans into the pharmacy's high-tech easily between one or the other and see a
computer systems, which can switch between the customer's complete information,
tills and PMR depending on who is using them "We also use loyalty cards quite a lot and if
Mr Clyde says: "Thinking about Scotland in someone buys a P medicine on their loyalty card
particular, with CMS coming, it is going to be so then it automatically goes onto their PMR record
much easier for us than some pharmacists as we for review."
are dealing directly with our customers. Customers have responded well to the changes,
he adds. Many have reported how much easier it
CPD Reflect • Plan • Act • Evaluate is to find products and are pleased the shop is so
close to the old site and near the health centre
Tips for your CPD entry on pharmacy design
Qne regular customeri E[eanor McBeathi says
REFLECT Does my pharmacy present a she en J°y s the customer service the pharmacy
professional image and support offers and feels offers a lot of extra services that
qualify for tax relief. Generally that is the case, year, the first £100,000 of capital expenditure in
but it is the timing of the tax relief that can vary any year (as long as it qualifies for capital
Expenditure on these projects falls into a If you are spending more than this, it can be
number of categories. It may: allocated to integral features first to accelerate
• qualify for capital allowances (which is the the tax relief.
Neuropathic pain
Following the publication of Nice guidelines on the pharmacological management
of neuropathic pain, Gavin Atkin explains what you need to know
Neuropathic pain arises from damaged or dysfunctional nerves, and In patients where the source of pain is not associated with diabetes,
can be due to a range of disorders affecting the peripheral and central the first-line treatments are oral amitriptyline starting at lOmg/day
nervous systems, including diabetic neuropathy, post-herpetic gradually titrated upward to the maximum tolerated dose up to
neuralgia and trigeminal neuralgia.
75mg/day, or pregabalin starting 150mg/day (or less in some
at
patients) in two daily doses with upward titration to the patient's
People with neuropathic pain may experience altered pain sensation, maximum tolerated dose of no higher than 600mg/day. If satisfactory
areas of numbness and continuous or intermittent evoked
or burning, pain reduction not achieved with
is first-line treatment at the maximum
or spontaneous pain. Neuropathic pain is an unpleasant sensory and tolerated dose, the patient should be referred to a pain clinic or offered
emotional experience that can have a significant impact on a person's another drug in addition or as an alternative to their first-line treatment.
quality of life.
The third-line options are oral tramadol and topical lidocaine.
Neuropathic pain remains difficult to treat because it is resistant to In patients whose pain is due to diabetic neuropathy, oral duloxetine
many medications and the effective treatments have adverse effects. should be offered as a first-line treatment, starting at 60mg/day (less
in some patients). Where duloxetine is contraindicated, amitryptyline
Patients should be referred to a specialist pain clinic or disease-specific
should be offered.
specialist at any stage if their pain is severe or limits daily activities, or
their underlying health deteriorates
If amitryptyline proves effective but the
patient is unable to tolerate its
adverse effects, oral imipramine or nortriptyline should be considered.
Patients' concerns and expectations should be addressed when
Reference: Neuropathic pain - pharmacological management,
agreeing which treatments to use, and these are likely to include the
http://guidance.nice.org.uk/CG96
benefits and possible adverse effects of pharmacological treatment,
coping strategies for dealing with pain and the adverse effects of
CPD Reflect • Plan • Act • Evaluate
drugs, and non-pharmacological treatments including surgery and
psychological therapies. Tips for your CPD entry on neuropathic pain management
The selection of treatments should take comorbidities, safety issues REFLECT Do understand current guidance on
I
the pharmacological
and contraindications into account, as well as mental health problems. management of neuropathic pain?
The titration process must be explained, and when withdrawing or
PLAN Assess which aspects of neuropathic pain management you
switching treatment, doses should be tapered. Clinicians should are least clear about
consider overlapping treatments to maintain the pain control. ACT Read this article and the relevant secti ons of the Nice
guidance (see reference above)
Patients should be reviewed shortly after a change in treatment to
EVALUATE Can I advise GPs and patients on drug treatment for
ensure it is suitable, and should be reviewed regularly.
neuropathic pain?
1 1.09.10 51 23
1
ence r FREE
[ REGISTER
{ TODAY
^ See below
for details .
:
10.20am
The five biggest challenges facing pharmacy and what the Society The new white paper - where next for NHS services?
will do to help you Alan Milburn, former secretary of state for health.
Helen Gordon, chief executive, the RPS The government's vision for primary care will see GPs charged with
As the RPSCB returns to its roots as the leadership body for commissioning local services as PCTs are consigned to the scrap heap.
pharmacists, its new chief executive reveals how the Society will steer Alan Milburn examines whether the new NHS blueprint will change the
pharmacists to a more rewarding professional future NHS landscape for better or for worse
11.00am
How your change under the new pharmacy regulator
life will A multiple's view of the new look NHS
Duncan Rudkin, chief executive, General Pharmaceutical Council Andy Murdock, director of pharmacy, Lloydspharmacy
Pharmacists have a new professional regulator but will it just lead to Following the white paper theme, Lloydspharmacy's Andy Murdock
tougher sanctions or will the promise of 'light become
touch' regulation identifies the opportunities and threats that pharmacy faces under the
a reality? The CPhC's Duncan Rudkin reveals what the profession's new latest NHS revolution
disciplinarian will mean for you
12.20pm
Generics, the NHS, and you
Pharmacy contract funding - a behind-the-scenes account of where Michael Cann, chairman, BGMA
we are and what the future holds Love 'em or hate 'em, generics play a major part in keeping the NHS
Sue Sharpe, chief executive, PSNC drugs bill down. Michael Cann looks at the opportunities that generics
PSNC chief executive Sue Sharpe explains what's happening in the provide for pharmacists including category M and generic substitution
latest round of contract funding negotiations and what the future NHS
Commissioning Body will mean for your funding
How ditching toiletries and cosmetics helped boost our healthcare
3.15pm business
The C+D Senate Live in association Kenny Black, managing director, Rowlands Pharmacy
with Actavis Rowlands Pharmacy has piloted a new front of shop business model
C + D's pharmacy think-tank holds its which has seen toiletries and cosmetics replaced with a greater focus
THE C+D SENATE will field questions from the audience. 1.40pm
IN ASSOCIATION
How to press your PCT's buttons when it comes to local
j_
with "actavis Don't miss this unique chance to be commissioning
part of the debate. Julie Wood, director, clinical commissioning, NHS Alliance
Panellists include: Ian Facer, Rob There's no escaping the 'c' word - it's a fact that commissioning is going
Darracott, Sue Sharpe, Michael Cann to be a big part of pharmacy's future. Julie Wood offers her tips on what
and David Reissner you need to do to get services commissioned
2.20pm
An examination of Co-op's blueprint for pharmacy
Chris Brooker, business development director. The Co-op Pharmacy
Every session will include an audience Q+A The Co-operative Pharmacy is one of the fastest growing multiple
PLUS interactive voting technology chains. Chris Brooker shares the company's blueprint for pharmacy and
offers his tips on maximising your business
University of
Hard copy applications can be obtained by telephoning 028 701 2 3456 Find out more from Jina and about
The University is an equal opportunities employer and welcomes applicants from all becoming a Pharmacist or Pharmacist
sections of the community, particularly from those with disabilities Appointment will be
Store Manager by visiting
made on merit
www.boots.jobs/pharmacy
you have probably worked in the industry and have a good Eynsham, Grove Wantage & Swindon
knowledge of retail pharmacy and pharmaceutical wholesaling. Bicester OXFORDSHIRE
Relief & Pharmacy
As this is a new position we are looking for an individual who Currently recruiting Managers required
understands the inextricable relationship between sales and Relief & Pharmacy
{negotiable + excellent
marketing and has excellent communication skills to develop Managers
benefits
the role both internally and externally.
{negotiable + excellent benefits
Please call Maria McElvenney on
In return, the Company is offering a comprehensive package Please call Maria McElvenney on 02476 432983 and email your CV co
02476 432983 and email your CV to maria.mcelvenney "alloydspharmacy.co.uk
with the great potential to grow with this exciting business.
maria.mcelvenney@lloydspharmacy.co.uk
11.09.10 25
Meet the C+D Jobs team at the 2010 Pharmacy Show
Register for your free ticket at www.chemistanddruggist.co.uk/thepharmacyshow (^^j
LOCUM PHARMACIST'S Find out more at our Open Evening from 5.45pm-7.15pm
on Monday 18th October 2010 in Rooms B62/B64
HANDBOOK 2009/10 Main Building, Malet Street, London WC1E 7HX
Your pocket guide to Locum Pharmacy Practice (entrance via Torrington Square).
HAVE YOU EVER CONSIDERED PUBLISHING YOUR OWN REF For further information:
BOOKS FOR ALL YOUR PHARMACIST COLLEAGUES ?? Email: biosciencesfd@bbk.ac.uk
WE CAN HELP !!! Web: http://www.bbk.ac.uk/study/ug/pharmacy/
UFSPHARM.html
UPP PUBLISHING SERVICE....( ARTWORK, PUBLISHING,
COPYRIGHT, DISTRIBUTION)
FOR FURTHER DETAILS, PLEASE CONTACT
The School of Pharmacy
University of London WeVmmsterKingsway
wk
J l * - 1 *t y
NATLOCUM@AOL.COM
i . I
26 Chemist+Druggist 1 1.09.10
Call 0207 921 8123
P WITH
\
\
I'll
Nl SHIER
WHOLE OR SEPARATELY
\ l< \l iCIES I/O £2 Mil
1 1)
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11.09.10 29
Got a story for Postscript?
postscript@chemistanddruggist.co.uk
condom suit and will be handing out free condoms the pharmacy, which have a condom stuck to As our exclusive 2010 Stock Survey reveals,
to 16 to 25-year-olds outside the shop this month. them. People are really responding well." there are some serious issues in the UK medicines
Sponsored by Pasante, which provided the Daniels Pharmacy has the suit for two more supply chain. And as the story gains traction in the
costume, and funded by Redbridge PCT, the stunt weeks, when it will be replaced by a hi-tech wider media, it is interesting to see what aspects
is designed to encourage young people to come glow-in-the-dark condom costume from the of our findings are teased out.
into the pharmacy to take advantage of free manufacturer The Daily Mail uses a combination of our survey
condom and lube packs, free chlamydia screening "The PCT has asked me to go clubbing in the data and a story it ran earlier this year to focus on
and other sexual health services. glow-in-the-dark suit," Mr Muir adds. "It's pretty the trading of drugs into the Eurozone. It says that
It has been timed to coincide with Redbridge hot in that thing. It's sweaty and grim, but it does one in 10 pharmacists, "as well as wholesalers,
PCT's sexual health campaign. appear to be having the desired effect." dispensing doctors and even NHS hospitals - are
making money from an export trade worth an
estimated £360 million a year".
The Scotsman, on the other hand, focuses much
more on how the lack of branded medicines is
Jason Muir: suited, booted, pumped up and ready to meet his suggestion that could resolve the stock crisis? Let
30 Ch jgeist 11.09.10
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FOSTAIR T
Beclometasone + formoterol
M
FOS- effects of inhaled corticosteroids may occur, particularly at high doses prescribed for cataract, atrial fibrillation, dyspnoea, exacerbation of asthma, growth retardation
(becjoi ionate and formoterol fumarate dihydrate) pressurised long periods. These effects are much less likely to occur with inhaled than with oral in children and adolescents, peripheral oedema, bone density decreased. Legal
inhalation solutioi corticosteroids. Possible systemic effects include Cushing's syndrome, Cushingoid Category: POM Packs and Prices: Fostair 100/6 PL08829/01 56) £29.32. Each
Prescribing Information features, adrenal suppression, decrease in bone mineral density, growth retardation in inhaler contains 120 actuations. Full prescribing information is available from the
(Refer to Summary of Product Characteristics before prescribing). children and adolescents, cataract and glaucoma. Titrate to the lowest dose at which Marketing Authorisation Holder Chiesi Limited, Cheadle Royal Business Park,
Presentations: Pressurised inhalation solution containing 100 micrograms of effective control of asthma is maintained to minimise systemic effects. Special care Highfield, Cheadle, SK8 3GY. Date of preparation: July 201 0.
beclometasone dipropionate and 6 micrograms of formoterol fumarate dihydrate per is needed in transferring patients from oral steroids. Fostair contains a small amount
actuation. Indications: Regular treatment of asthma where use ot a combination of ethanol (approximately 7mg per actuation); at normal doses the amount of ethanol REFERENCES
product (inhaled corticosteroid and long-acting beta 2 -agonist) is appropriate: patients is negligible and does not pose a risk to patients. Patients should rinse mouth after 1 . De Backer W, Devolder A, Poli G et al. Lung deposition of BDP/formoterol HFA
not adequately controlled with inhaled corticosteroids and 'as needed' inhaled inhalation to minimise risk of oropharyngeal Candida infection. Drug interactions: pMDI in healthy volunteers, asthmatic and COPD patients. J Aerosol Med Pulm
short-acting beta2 agonist; or patients already adequately controlled on both inhaled Beclometasone dipropionate undergoes a very rapid metabolism via esterase Drug Deliv 2010; 23(3): 137-148.
corticosteroids and long-acting beta2 -agonists. Not appropriate for treatment of acute enzymes without involvement of the cytochrome p450 system. Avoid beta-blockers 2. Selroos 0, Pietinalho A, Riska H. Delivery devices for inhaled asthma medication.
asthma attacks. Dosage and Administration: For inhalation use only. Fostair is (including eye drops). Caution is required when theophylline or other beta-adrenergic Clin Immunother 1996; 6: 273-299.
not intended for the initial management of asthma. If an individual patient should drugs are prescribed concomitantly with formoterol. Concomitant treatment with 3. Fabbri LM, Nicolini G, Olivieri D et al. Inhaled beclometasone dipropionate/
require a combination of doses other than those available in the combination inhaler, quinidine, disopyramide, procainamide, phenothiazines, antihistamines, MAOIs and formoterol extra-fine fixed combination in the treatment of asthma: evidenc'e
appropriate doses of beti-agonists and/or corticosteroids by individual inhalers should TCAs can prolong the QTc and increase the risk of ventricular arrhythmias.
interval and future perspectives. Expert Opin Pharmacother 2008; 9: 479-490.
be prescribed. Adults: one or two inhalations twice daily, maximum four inhalations In addition, L-dopa, L-thyroxine, oxytocin and alcohol can impair cardiac tolerance. 4. Tulic MK, Hamid Q. New insights into the pathophysiology of the small airways
daily. Not recommended for patients under 1 8 years. Beclometasone dipropionate Concomitant administration with MAOIs, including agents with similar properties such in asthma. Clin Chest Med 2006; 27: 41-52.
in Fostair is characterised by an extra-fine particle size distribution which results in as furazolidone and procarbazine, may precipitate hypertension. Risk of arrhythmias 5. Huchon G, Magnussen H, Chuchalin A et al. Lung function and asthma contra
a more potent effect than formulations of beclometasone dipropionate with a non in patients receiving anaesthesia with halogenated hydrocarbons. Theoretical potential with beclomethasone and formoterol in a single inhaler. Respir Med 2009 1 03 ;
extra-fine particle size distribution (100 micrograms of beclometasone dipropionate for interaction in sensitive patients taking disulfiram or metronidazole. Pregnancy 41-49.
extra-fine in Fostair are equivalent to 250 micrograms of beclometasone dipropionate and Lactation: No experience. Balance risks with benefits. Side effects: Common:
in a ncn extra-fine formulation). Therefore the total daily dose of beclometasone pharyngitis, headache, dysphonia. Uncommon: influenza, oral fungal infection AeroChamber Plus™ is a licensed trademark of Trudell Medical Internation
dipropionate administered in Fostair should be lower than the total daily dose of pharyngeal and oesophageal candidiasis, vaginal candidiasis, gastroenteritis Date of preparation: JULY 2010 Job code: CHFOS20100392
1
beclometasone dipropionate administered in a non-extra-fine beclometasone sinusitis, granulocytopenia, dermatitis allergic, hypokalaemia, hyperglycaemia
dipropionate formulation. Fostair may be used with the AeroChamber Plus™ spacer restlessness, tremor, dizziness, otosalpingitis, cardiac arrhythmias, hyperaemia
device. Patients' should be advised in the proper use and care of their inhaler and flushing, rhinitis, cough, productive cough, throat irritation, asthmatic crisis, pruritus GChiesi
spacer. Contraindications: Hypersensitivity to any of the components. Precautions: . rash, hyperhidrosis, diarrhoea, dry mouth, dyspepsia, dysphagia, burning sensation of
Cardiovascular disorders including cardiac arrhythmias, thyrotoxicosis, diabetes the lips, nausea, dysgeusia, muscle spasms, myalgia, Crreactive protein increased
mellitus, '
phaeochromocytoma, untreated hypokalemia, pulmonary infections platelet count increased, free fatty acids increased, blood insulin increased, blood Adverse events should be reported.
(tuberculosis^ fungal or viral). Fostair should not be used as the first treatment for ketone body increased. Rare: ventricular extrasystoles, angina pectoris, paradoxical Reporting forms and information can be found at www.yellowcard.gov.uk
asthma, should not be initiated during an exacerbation, or during significantly bronchospasm, urticaria, angioneurotic oedema, nephritis, blood pressure i
Adverse events should also be reported to Chiesi Limited (address as above
worsening or acutely deteriorating asthma, and should not be stopped abruptly. If blood pressure decreased. Very
patients find the treatment ineffective medical attention must be sought. Systemic adrenal suppression, abnormal