California Safe Cosmetics: Reportable Ingredients List
California Safe Cosmetics: Reportable Ingredients List
The California Safe Cosmetics Act of 2005 requires cosmetic manufacturers to disclose to the California Department of
Public Health (CDPH) all products containing ingredients known or suspected to cause cancer, birth defects, or other
reproductive toxicity as determined by the authoritative scientific bodies cited in California Health and Safety Code
Section 111791.5. These bodies are 1) the California Office of Environmental Health Hazard Assessment (Proposition 65
List of Chemicals Known to Cause Cancer or Reproductive Toxicity); 2) U.S. Environmental Protection Agency (U.S.
EPA); 3) National Toxicology Program (NTP) Office of Health Assessment and Translation (OHAT) (formerly Center for
the Evaluation of Risks to Human Reproduction (CERHR)); 4) NTP’s Report on Carcinogens (RoC); and 5) the
International Agency for Research on Cancer (IARC).
To assist companies with reporting, CDPH has compiled this list of reportable ingredients based on lists and reports
available from these organizations. Please note that the authoritative bodies are continually updating published
information. For the most up-to-date guidance on reportable chemicals, please refer directly to the lists and reports
available from these organizations.
Chemical Abstract Service (CAS) Registry Numbers and synonyms are provided for some of the listed chemicals.
However, this guidance document is not all-inclusive. Manufacturers may still be required to report a chemical to CDPH
even if a specific synonym or CAS number for an ingredient is not listed here.
Note to consumers: Not all of these chemicals are found in cosmetic products. Also, note that the likelihood of a cosmetic
product leading to cancer or reproductive harm depends on many factors, including but not limited to the amount and type
of exposure to chemicals in the product. The chemicals are listed here because of findings from research on the
chemicals and not on cosmetic products.
For more information on the California Safe Cosmetics Program, please visit our web page at:
www.cdph.ca.gov/Cosmetics or call us at (877) 325-3223.
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Chemical Synonyms CAS No.
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-
1 Semustine 13909-09-6 x x
nitrosourea (Methyl-CCNU)
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
2 13010-47-4 x x x
(CCNU) (Lomustine)
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
13010-47-4 x x
(CCNU) (Lomustine)
3 1,1,1,2-Tetrachloroethane 630-20-6 x x x x
4 1,1,2,2-Tetrachloroethane 79-34-5 x x x x
5 1,1-Dichloro-2,2-bis(p -chloropheny)ethylene (DDE) 72-55-9 x x x
6 1,1-Dichloroethane 75-34-3 x x x
7 1,1-Dimethylhydrazine (UDMH) 57-14-7 x x x x
8 1,2,3-Trichloropropane 96-18-4 x x x x
9 1,2-Dibromo-3-chloropropane (DBCP) 96-12-8 x x x
1,2-Dibromo-3-chloropropane (DBCP) 96-12-8 x x
10 1,2-Dichloropropane 78-87-5 x x x
11 1,2-Diethylhydrazine 1615-80-1 x x x
12 1,2-Dimethylhydrazine 540-73-8 x x x
13 1,2-Epoxybutane 106-88-7 x x
14 1,3-Butadiene 106-99-0 x x x
1,3-Butadiene 106-99-0 x x x x x x
15 1,3-Dichloro-2-propanol (1,3-DCP) 96-23-1 x x x
16 1,3-Dichloropropene 542-75-6 x x x
17 1,3-Dinitropyrene 75321-20-9 x x x
18 1,3-Propane sultone 1120-71-4 x x x
19 1,4-Butanediol dimethanesulfonate Busulfan 55-98-1 x x x x
20 1,4-Dichloro-2-butene 764-41-0 x x
21 1,4-Dichloro-2-nitrobenzene 89-61-2 x x x
22 1,4-Dioxane 123-91-1 x x x x
23 1,6-Dinitropyrene 42397-64-8 x x x
24 1,8-Dinitropyrene 42397-65-9 x x x
25 1-[(5-Nitrofurfurylidene)-amino]-2-imidazolidinone 555-84-0 x x x
26 1-Amino-2,4-dibromoanthraquinone 81-49-2 x x x x
27 1-Amino-2-methylanthraquinone 82-28-0 x x
28 1-Bromo-3-chloropropane 109-70-6 x x
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Chemical Synonyms CAS No.
58 2-Amino-4-chlorophenol 95-85-2 x x x
59 2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 712-68-5 x x x
60 2-Aminoanthraquinone 117-79-3 x x
61 2-Aminofluorene 153-78-6 x x
62 2-Bromopropane (2-BP) 75-26-3 x x x
63 2-Chloronitrobenzene 88-73-3 x x x
64 2-Chloropropionic acid 598-78-7 x x
65 2-Ethylhexyl acrylate 103-11-7 x x
66 2-Mercaptobenzothiazole 149-30-4 x x x
67 2-Methyl-1-nitroanthraquinone (of uncertain purity) 129-15-7 x x x
68 2-Methylaziridine (Propyleneimine) 75-55-8 x x x
69 2-Methylimidazole 693-98-1 x x x
70 2-Naphthylamine 91-59-8 x x x
71 2-Nitrofluorene 607-57-8 x x x
72 2-Nitropropane 79-46-9 x x x
73 3-(N-Nitrosomethylamino) propionitrile 60153-49-3 x x x
74 3,3',4,4'-Tetrachloroazobenzene 14047-09-7 x x x x
75 3,3'-Dichloro-4,4'-diamino-diphenyl ether 28434-86-8 x x x
76 3,3'-Dichlorobenzidine 91-94-1 x x x x
77 3,3'-Dichlorobenzidine dihydrochloride 612-83-9 x x x
78 3,3'-Dimethoxybenzidine (o -Dianisidine) 119-90-4 x x x
79 3,3'-Dimethoxybenzidine dihydrochloride 20325-40-0 x x x
3,3'-Dimethoxybenzidine-based dyes metabolized
80 --- x x x
to 3,3'-dimethoxybenzidine
81 3,3'-Dimethylbenzidine (ortho-Tolidine) 119-93-7 x x x
82 3,3'-Dimethylbenzidine dihydrochloride 612-82-8 x x x
3,3'-Dimethylbenzidine-based dyes metabolized to
83 --- x x x
3,3'-dimethylbenzidine
84 3,4,5,3’,4’-Pentachlorobiphenyl (PCB-126) 57465-28-8 x x
85 3,7-Dinitrofluoranthene 105735-71-5 x x x
86 3,9-Dinitrofluoranthene 22506-53-2 x x x
87 3-Amino-9-ethylcarbazole hydrochloride 6109-97-3 x x
88 3-Chloro-2-methylpropene 563-47-3 x x
89 3-Chloro-2-methylpropene, technical grade 563-47-3 x x
90 3-Methylcholanthrene 56-49-5 x x
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Chemical Synonyms CAS No.
3-Monochloro-1,2-
91 3-Monochloropropane-1,2-diol (3-MCDP) 96-24-2 x x x
propanediol
92 3-Nitrobenzanthrone 17117-34-9 x x
93 4-(N-Nitrosomethylamino)-1-(3-pyridyl)1-butanone 64091-91-4 x x
94 4,4'-Diaminodiphenyl ether (4,4'-Oxydianiline) 101-80-4 x x x
95 4,4'-Methylene bis(2-chloroaniline) 101-14-4 x x x x
96 4,4'-Methylene bis(2-methylaniline) 838-88-0 x x x
97 4,4'-Methylene bis(N,N-dimethyl)benzenamine Michler’s base 101-61-1 x x x
98 4,4'-Methylenedianiline 101-77-9 x x x
99 4,4'-Methylenedianiline dihydrochloride 13552-44-8 x x
100 4,4'-Thiodianiline 139-65-1 x x x
101 4-Amino-2-nitrophenol 119-34-6 x x
102 4-Aminobiphenyl (4-aminodiphenyl) 92-67-1 x x x
103 4-Chloro-o -phenylenediamine 95-83-0 x x x
104 4-Chlorobenzotrifluoride 98-56-6 x x
para -
105 4-Dimethylaminoazobenzene Dimethylaminoazobenz 60-11-7 x x x
ene
106 4-Methylimidazole 822-36-6 x x x
107 4-Nitrobiphenyl 92-93-3 x x
108 4-Nitropyrene 57835-92-4 x x x
4-Vinyl-1-cyclohexene diepoxide (Vinyl 4-Vinylcyclohexene
109 106-87-6 x x
cyclohexenedioxide) diepoxide
110 4-Vinylcyclohexene 100-40-3 x x x
4-Vinylcyclohexene 100-40-3 x x
5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)-
111 139-91-3 x x x
amino]-2-oxazolidinone
5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)-
3795-88-8 x x
amino]-2-oxazolidinone
112 5-Chloro-o -toluidine and its strong acid salts --- x x
113 5-Methoxypsoralen with ultraviolet A therapy 484-20-8 x x x
114 5-Methylchrysene 3697-24-3 x x x
115 5-Nitroacenaphthene 602-87-9 x x x
116 6-Nitrochrysene 7496-02-8 x x x
117 7,12-Dimethylbenz(a)anthracene 57-97-6 x x
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Chemical Synonyms CAS No.
68515-49-1
377 Di-isodecyl phthalate (DIDP) x x
26761-40-0
378 Diisononyl phthalate (DINP) --- x x
379 Diisopropyl sulfate 2973-10-6 x x x
380 Diltiazem hydrochloride 33286-22-5 x x
381 Dimethyl sulfate 77-78-1 x x x
382 Dimethylcarbamoyl chloride 79-44-7 x x x
N ,N -
383 Dimethylformamide 68-12-2 x x x
Dimethylformamide
1-Chloro-2-
384 Dimethylvinylchloride 513-37-1 x x x
methylpropene
385 Di-n -butyl phthalate (DBP) 84-74-2 x x x x x
386 Di-n -hexyl phthalate (DnHP) 84-75-3 x x x
387 Dinitrotoluene (technical grade) --- x x x
388 Dinitrotoluene mixture, 2,4-/2,6- --- x x x
389 Dinocap 39300-45-3 x x
390 Dinoseb 88-85-7 x x x
Di-n -propyl isocinchomeronate (MGK Repellent
391 136-45-8 x x
326)
392 Diphenylhydantoin (Phenytoin) 57-41-0 x x x
Diphenylhydantoin (Phenytoin) 57-41-0 x x
393 Diphenylhydantoin (Phenytoin), sodium salt 630-93-3 x x
394 Direct Black 38 (technical grade) 1937-37-7 x x
395 Direct Blue 6 (technical grade) 2602-46-2 x x
396 Direct Brown 95 (technical grade) 16071-86-6 x x
397 Disodium cyanodithioimidocarbonate 138-93-2 x x x
398 Disperse Blue 1 2475-45-8 x x x
399 Diuron 330-54-1 x x x
400 Doxorubicin hydrochloride (Adriamycin) 25316-40-9 x x x x
401 Doxycycline (internal use) 564-25-0 x x
402 Doxycycline calcium (internal use) 94088-85-4 x x
403 Doxycycline hyclate (internal use) 24390-14-5 x x
404 Doxycycline monohydrate (internal use) 17086-28-1 x x
405 Endrin 72-20-8 x x x
406 Environmental tobacco smoke (ETS) --- x x
407 Epichlorohydrin 106-89-8 x x x x
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Chemical Synonyms CAS No.
Epichlorohydrin 106-89-8 x x x
408 Epoxiconazole 135319-73-2 x x
409 Ergotamine tartrate 379-79-3 x x
12510-42-8
410 Erionite x x x
66733-21-9
411 Estradiol 17B 50-28-2 x x
412 Estragole 140-67-0 x x
413 Estrogen therapy, postmenopausal --- x x
Estrogen-progestogen (combined) used as
414 --- x x x x
menopausal therapy
415 Estrogens, nonsteroidal, e.g. diethylstilbestrol --- x x x
416 Estrogens, steroidal --- x x
417 Estrone 53-16-7 x x
418 Estropipate 7280-37-7 x x x
419 Ethanol in alcoholic beverages 64-17-5 x x x
420 Ethinylestradiol 57-63-6 x x
421 Ethionamide 536-33-4 x x
422 Ethoprop 13194-48-4 x x
423 Ethyl acrylate 140-88-5 x x x
424 Ethyl alcohol in alcoholic beverages --- x x
425 Ethyl dipropylthiocarbamate 759-94-4 x x x
426 Ethyl methanesulfonate 62-50-0 x x x
427 Ethyl-4,4'-dichlorobenzilate 510-15-6 x x
428 Ethylbenzene 100-41-4 x x x
429 Ethylene dibromide 1,2-Dibromoethane 106-93-4 x x x x x
Ethylene dibromide 1,2-Dibromoethane 106-93-4 x x x x
430 Ethylene dichloride (1,2-Dichloroethane) 107-06-2 x x x x
431 Ethylene glycol (ingested) 107-21-1 x x
432 Ethylene glycol monoethyl ether 110-80-5 x x x
433 Ethylene glycol monoethyl ether acetate 111-15-9 x x x
434 Ethylene glycol monomethyl ether 109-86-4 x x x
435 Ethylene glycol monomethyl ether acetate 110-49-6 x x x
436 Ethylene oxide 75-21-8 x x x x x
Ethylene oxide 75-21-8 x x x x
437 Ethylene thiourea 96-45-7 x x x
Ethylene thiourea 96-45-7 x x
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