Canada
Canada
  Abstract
  Background: In spite of the evidence supporting the importance of breastfeeding during the first year of life, data
  on breastfeeding practices remain limited in Canada. The study aimed to examine the prevalence and predictors of
  6-month exclusive breastfeeding among Canadian women.
  Methods: The analysis was based on the Maternity Experience Survey targeting women aged ≥ 15 years who had
  singleton live births between February 2006 - May 2006 in the Canadian provinces and November 2005 - February
  2006 in the territories. The main outcome was exclusive breastfeeding based on the World Health Organization
  definition. Socioeconomic, demographic, maternal, pregnancy and delivery related variables were considered for a
  multivariate logistic regression using stepwise modeling. Bootstrapping was performed to account for the complex
  sampling design.
  Results: The sample size in this study was 5,615 weighted to represent 66,810 Canadian women. While ever
  breastfeeding was 90.3%, the 6-month exclusive breastfeeding rate was 13.8%. Based on the regression model,
  having higher years of education, residing in the Northern territories and Western provinces, living with a partner,
  having had previous pregnancies, having lower pre-pregnancy body mass index and giving birth at older age were
  associated with increased likelihood of 6-month exclusive breastfeeding. Moreover, smoking during pregnancy,
  Caesarean birth, infant’s admission to the intensive care unit and maternal employment status before 6 months of
  infant’s age were negatively associated with exclusive breastfeeding. Mothers choosing to deliver at home were
  more likely to remain exclusively breastfeeding for 6 months (Odds Ratio: 5.29, 95% Confidence Interval: 2.95-9.46).
  Conclusions: The 6-month exclusive breastfeeding rate is low in Canada. The study results constitute the basis for
  designing interventions that aim to bridge the gap between the current practices of breastfeeding and the World
  Health Organization recommendation.
Maclean (2005) reported that only 17% of women in               computer-assisted telephone interview application. Inter-
Canada conform with the 6-month exclusive breastfeed-           views were conducted between the 5th and 14th month
ing recommendation of the WHO. Based on the Cana-               after delivery and lasted on average 45 minutes. The
dian studies, exclusive breastfeeding was significantly         majority (96.9%) of the interviews, however, were per-
more common among urban residents [14], women with              formed between the 5th and 9th month postpartum. The
high education [11,14] and older mothers [11,14]. Risk          MES has been previously described in other references
factors for early breastfeeding termination were also           [22].
found to be associated with early hospital discharge,             The present study considered the 5615 MES mothers
minimal breastfeeding support and receiving advice on           (87.4%) who had babies aged ≥ 6 month at the time of
formula feeding [9].                                            interview. Mothers were weighted to represent 66,810
   Acquiring information on the predictors of breastfeed-       Canadian women. The main outcome of the study was
ing may better equip policy makers and public health            exclusive breastfeeding based on the WHO definition as
practitioners in designing programs for at-risk groups          the intake of breast milk only without any other drink
and may help to bring the entire population closer to the       or food for the first 6 months of infant’s age [5]. This
infant feeding practices recommended by Health Canada           outcome was dichotomous (<6 months, ≥ 6 months)
and the WHO. In spite of the evidence supporting the            and was calculated using information about breastfeed-
importance of breastfeeding during the first year of life       ing termination and timing of introduction of liquids,
and the variety of health outcomes that are related to          semi-solid and solid foods. Other breastfeeding variables
breastfeeding, data on breastfeeding practices remain lim-      that were considered were, ever breastfeeding assessed
ited in Canada. Canadian studies are mostly representa-         by the question “did you breastfeed or try to breastfeed
tive of specific regions/provinces [10,12,13,15-17] and         even if only for a short time?” and breastfeeding inten-
specific populations such as teenagers [18], low income         tion measured by the question “prior to giving birth, did
mothers [19], female physicians [20] and primipara              you intend to feed by formula alone, breastfeeding alone
mothers [21]. To our knowledge, only one nationwide             or a combination of both?”
study, using data from 2003, assessed the prevalence and          A wide range of variables were investigated as potential
predictors of breastfeeding across the Canadian provinces       predictors of exclusive breastfeeding. Socio-economic sta-
[14]. The study, however, excluded mothers in the north-        tus, such as maternal years of education, total household
ern territories. It also assessed breastfeeding status within   income and place of residence, and demographic factors,
the previous 5 years thereby increasing the chance of           consisting of immigration status and province of resi-
recall bias. The study, as well, investigated limited demo-     dence, were considered. Information about maternal
graphic and socio-economic predictors. The present              characteristics including marital status, age at first preg-
study, however, used data from a recent specialized sur-        nancy, number of previous pregnancies, age at selected
vey on pre and post delivery experiences among mothers          birth, pre-pregnancy maternal body mass index (BMI)
residing in both the Canadian provinces and territories. It     and mother’s perceived health were also assessed.
aimed to examine the prevalence of exclusive breastfeed-        Furthermore, pregnancy related factors composed of: self
ing at 6 months and the potential socio-economic, demo-         reported weight gain during pregnancy, ever taking alco-
graphic, maternal, pregnancy and delivery related               hol during pregnancy, ever smoking during the third tri-
predictors.                                                     mester of pregnancy, support during pregnancy, mother’s
                                                                reaction to pregnancy, mother’s stress level before and
Methods                                                         during pregnancy, health problems during pregnancy,
The analysis of this study was based on the Maternity           attendance of prenatal classes, number of prenatal care
Experience Survey (MES) that was sponsored by Public            visits and type of prenatal care provider were explored as
Health Agency of Canada and conducted by Statistics             well. Finally, delivery related factors (type of delivery, type
Canada in 2006. The MES study is the first nationwide           of birth setting, birth weight, gestational age and baby’s
survey that assessed pregnancy, delivery and postnatal          admission to neonatal intensive care unit) and postpar-
experiences of mothers and their children. The study            tum variables (hospitalization of baby, support after birth,
sample was selected from the Canadian Census of Popu-           work status after birth and postpartum depression) were
lation to include women aged ≥ 15 years who had sin-            examined. All the variables, except for mother’s stress
gleton live births between February 15, 2006 and May,           level and postpartum depression, were directly self-
2006 in the provinces of Canada and November 1, 2005            reported by the mother. The mother’s stress level was
and February 1, 2006 in the territories of Canada. A            measured through a set of 13 questions that examined
total of 8,542 Canadian women were selected, out of             the mother’s experience of stressful events in the past
which 6,421 (75.2%) responded to the survey. The data           12 months before the birth of her selected child. The
was collected through telephone interviews using a              questions were adapted by Pregnancy Risk Assessment
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Monitoring System (PRAMS) from Newton and Hunt’s                             around 90% of the women intended to breastfeed their
Life Events Inventory [23]. The answers for these ques-                      child. Exclusive breastfeeding rates from 1 to 6 months
tions were categorised as “Yes” or “No”. Consequently,                       are illustrated in Figure 1. At 1 month, the exclusive
the sum of the “Yes” responses was calculated for each                       breastfeeding rates were 63.6% (95% CI: 62.3%-64.9%). By
mother to represent her stress level [24]. Postpartum                        3 months, half of the Canadian women were exclusively
depression, on the other hand, was assessed using the                        breastfeeding (50.4%, 95% CI: 48.2%-50.9%). The 6-month
Edinburgh Postpartum Depression Scale [25]. The scale                        exclusive breastfeeding rate was 13.8% (95% CI: 12.9-14.8)
consists of 10 items with four response categories scored                    while more than half of the women remained breastfeed-
from 0 to 3, whereby the highest values represent                            ing at 6 months of infant’s age. Figure 2 compares the
depressed moods. The sum of scores represents the                            breastfeeding rates across the Canadian provinces and
mother’s level of postpartum depression [24].                                territories (P-value < 0.001). The Northern Territories
  The prevalence of exclusive breastfeeding was estimated                    and British Columbia demonstrated the highest preva-
through population weights and examined across all the                       lence of exclusive breastfeeding at 6 months (21.2% and
Canadian provinces and territories. At the bivariate level,                  19.2%, respectively). The rate in Newfoundland and Lab-
differences in the proportion of exclusive breastfeeding                     rador and Prince Edward Islands, on the other hand, was
were assessed among the different levels of each predictor                   the lowest at 6.5%.
using normalized weights. Chi square tests and odds                            Unadjusted associations between exclusive breastfeed-
ratios (OR) using 95% confidence intervals (95% CI) were                     ing and potential predictors are shown in Table 2. Out
performed for categorical variables. Differences in means                    of the 30 variables that were considered for stepwise
and 95% confidence interval estimations were employed                        logistic regression, 12 variables were retained in the final
for continuous variables. All the independent variables                      model (Table 3). Years of education was the only signifi-
were considered for a multivariate logistic regression ana-                  cant socioeconomic variable (OR: 1.08, 95% CI: 1.05-
lysis using stepwise modeling. Adjusted OR and 95% CI                        1.12). Out of the demographic variables tested, province
were reported for the final model. To account for the                        of residence remained in the model. As compared to
complex sampling design, bootstrapping was performed                         Eastern Atlantic provinces, the residents of Northern
to calculate the 95% CI estimates. Population weights,                       Territories and British Columbia were 3.01 (95% CI:
normalized weights and bootstrap weights were all cre-                       2.21-4.12) and 1.94 (95% CI: 1.42-2.64), respectively,
ated by Statistics Canada and provided with the MES                          more likely to exclusively breastfeed for the first 6
data file. All analyses, in exception to bootstrapping, were                 months of the infant’s life. Mothers with partners,
conducted using the Statistical Package for Social                           mothers with lower BMI before pregnancy, mothers
Sciences (SPSS, version 17.0). Bootstrapping was per-                        who had more pregnancies and mothers who had their
formed using the Statistical Analysis Software (SAS, ver-                    first pregnancy at an older age also had an increased
sion 9.2). Statistical significance for all analyses was set at              likelihood of breastfeeding exclusively for 6 months.
alpha <0.05 for a two tailed tests.                                          Furthermore, smoking during pregnancy was negatively
                                                                             associated with exclusive breastfeeding (OR: 2.11, 95%
Results                                                                      CI: 1.36-3.27). Women giving birth at home were 5
Table 1 presents the estimated population and distribu-                      times more likely to exclusively breastfeed than those
tion of breastfeeding related outcomes. During pregnancy,                    who gave birth at hospitals or clinics. Vaginal delivery
                                                                             was also found to increase the exclusive breastfeeding
Table 1 Estimated frequency distribution of                                  rates at 6 months by 25% as compared to Caesarean
breastfeeding related variables                                              delivery (OR: 1.25, 95% CI: 1.01-1.53). Finally, mothers
                                                   N*      % (95% CI)†       who had their babies admitted to neonatal intensive
Intention of breastfeeding before child birth                                care unit after birth and mothers who returned to work
    Formula feeding alone                        6,610    9.9 (9.2-10.7)     within the first 6 postpartum months were less likely to
    Breastfeeding alone                          49,850   75.0 (73.8-76.1)   achieve 6-month exclusivity of breastfeeding.
    Combination of formula & breastfeeding       10,027   15.1 (14.1-16.1)
Ever breastfeeding                               60,309   90.3 (89.6-91.1)   Discussion
Liquids were first introduced at ≥ 6 months      17,182   25.8 (24.6-27.0)   The present study aimed to investigate the prevalence
Solids were first introduced at ≥ 6 months       21,306   31.9 (30.6-33.2)   and predictors of exclusive breastfeeding at 6 months
Breastfeeding termination at ≥ 6 months          35,946   53.9 (52.6-55.2)   among mothers throughout the Canadian provinces and
Exclusive breastfeeding for ≥ 6 months           9,217    13.8 (12.9-14.8)   territories. Although ever breastfeeding was 90.3%, half
                                                                             of the Canadian mothers exclusively breastfed their
* Sample size is estimated using population weights
† 95% CI were calculated using bootstrapping technique                       babies for 3 months and only 13.8% of the mothers
                                                                             remained exclusively breastfeeding for 6 months.
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Figure 1 Exclusive breastfeeding rates during the first 6 months of life across the Canadian provinces and territories (2005/06).
 Figure 2 Distribution of 6-month exclusive breastfeeding rates across the Canadian provinces and territories (2005/06). Note: P-value <
 0.001
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Table 2 Unadjusted associations between 6-month exclusive breastfeeding and potential predictors
                                               Sample size   Exclusive breast-feeding   Unadjusted odds ratio
                                               N*            N* (%)                     OR (95% CI)†
Household income (Canadian dollar)
    <$30,000                                   908           98 (10.8)                  1
    $30,000 to less than $60,000               1,640         194 (11.8)                 1.11 (0.84-1.47)
    $60,000 to less than $100,000              1,657         231 (13.9)                 1.35 (1.02-1.77)
    ≥ $100,000                                 1,052         213 (20.2)                 2.11 (1.60-2.79)
Place of residence
    Rural area                                 973           129 (13.3)                 1
    Urban, population ≤ 499,999                1,976         247 (12.5)                 0.93 (0.75-1.17)
    Urban, population ≥ 500,000                2,436         363 (14.9)                 1.15 (0.92-1.43)
Immigrant mother
   No                                          4,334         559 (12.9)                 1
    Yes                                        1,239         207 (16.7)                 1.36 (1.12-1.64)
Marital status
    No partner                                 473           27 (5.7)                   1
    Have a partner                             5,105         743 (14.6)                 2.79 (1.86-4.18)
Moms perceived health
    Excellent/very good                        4,022         596 (14.8)                 2.11 (1.30-3.43)
    Good                                       1,274         154 (12.1)                 1.67 (0.99-2.80)
    Poor/Fair                                  304           23 (7.6)                   1
Reaction when discovered pregnancy
    Very happy/happy                           5,184         722 (13.9)                 1
    Indifferent                                238           27 (11.3)                  0.78 (0.50-1.21)
    Very unhappy/Unhappy                       164           21 (12.8)                  0.89 (0.54-1.48)
Smoking during pregnancy
    No                                         4,982         740 (14.9)                 3.15 (2.12-4.68)
    Yes                                        607           32 (5.3)                   1
Alcohol drinking during pregnancy
    No                                         4,982         677 (13.6)                 0.82 (0.64-1.06)
    Yes                                        586           94 (16.0)                  1
Health problems during pregnancy
    No                                         4,232         610 (14.4)                 1.23 (1.01-1.50)
    Yes                                        1,365         164 (12.0)                 1
Support during pregnancy
    None/Little of time                        289           37 (12.8)                  0.92 (0.61-1.40)
    Some of the time                           448           69 (15.4)                  1.14 (0.86-1.52)
    Most/All of time                           4,846         666 (13.7)                 1
Attended prenatal classes
    No                                         3,770         520 (13.8)                 1
    Yes                                        1,830         253 (13.8)                 1.00 (0.85-1.18)
Prenatal care provider
    Non-physician                              397           102 (25.7)                 2.34 (1.81-3.02)
    Physician                                  5,175         668 (12.9)                 1
Type of setting of baby’s birth
    Hospital or clinic                         5,485         728 (13.3)                 1
    Birthing centre                            43            7 (16.3)                   1.22 (0.44-3.39)
    Private home                               71            37 (52.1)                  7.13 (4.24-11.98)
Type of delivery
    Vaginal                                    4,146         605 (14.6)                 1.31 (1.08-1.58)
    Caesarean                                  1,456         168 (11.5)                 1
Baby’s admission to NICU
    No                                         4,875         711 (14.6)                 1.83 (1.38-2.44)
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Table 2: Unadjusted associations between 6-month exclusive breastfeeding and potential predictors (Continued)
     Yes                                                     722                        62 (8.6)                                  1
Baby’s hospitalization after birth
     No                                                      5,167                      727 (14.1)                                1.46 (1.03-2.07)
    Yes                                                      432                        44 (10.2)                                 1
Mother’s work status <6 months of delivery
     No                                                      5,084                      715 (14.1)                                1.30 (0.97-1.74)
     Yes                                                     491                        55 (11.2%)                                1
Support after birth
     None/Little of time                                     322                        61 (18.9)                                 1.50 (1.07-2.09)
     Some of the time                                        583                        80 (13.7)                                 1.02 (0.77-1.33)
     Most/All of time                                        4,687                      633 (13.5)                                1
Province‡
     Eastern- Atlantic                                       323                        28 (8.7)                                  1
     Eastern- Central                                        3,523                      448 (12.7)                                1.52 (1.21-1.91)
     Western- Prairies                                       1,056                      163 (15.4)                                1.89 (1.46-2.45)
     Western- British Columbia                               668                        128 (19.2)                                2.46 (1.83-3.30)
     Northern territories                                    33                         7 (21.2)                                  2.69 (2.06-3.53)
                                                                                                              Unadjusted Mean difference§
                                                                                                                       (95% CI)†
Mother’s education level (years)                             5,538                      1.20 (0.97-0.43)
Age at first pregnancy (years)                               5,527                      1.88 (1.47-2.29)
Number of past pregnancies                                   5,581                      0.16 (0.04-0.28)
Mother’s age at selected birth (years)                       5,581                      2.04 (1.67-2.41)
Weight gained during pregnancy (Kg)                          5,535                      -0.41 (-0.94-0.12)
BMI before pregnancy (Kg/m2)                                 5,508                      -0.90 (-1.31–0.48)
Infant’s birth weight (grams)                                5,590                      44.39 (0.05-0.30)
Gestational age (weeks)                                      5,419                      0.17 (0.95-87.84)
Number of stressful events                                   5,556                      -0.23 (-0.33–0.12)
Number of prenatal visits                                    5,364                      -0.07 (-0.41-0.27)
Edinburgh Postnatal Depression Scale                         5,529                      -0.28 (-0.63-0.08)
* Sample size is estimated using normalized weights
† 95% CI were calculated using bootstrapping technique
‡ Eastern Atlantic: Newfoundland & Labrador, Nova Scotia, Prince Edward Island & New Brunswick; Eastern Central: Quebec & Ontario; Western Prairies: Manitoba,
Saskatchewan, & Alberta; Western British Columbia: British Columbia; and Northern Territories: Yukon Territory, Nunavut & Northwest Territories.
§Represents the difference between the mean of exclusive breastfeeders and non- exclusive breastfeeders (Meanexclusive breastfeeders - Meannon-exclusive breastfeeders).
  The exclusive breastfeeding rates decreased consider-                               Ontario, were reported to be 28%, 22% and 18% respec-
ably from 1 month to 6 months among Canadian                                          tively, while, in the present study, they were been mea-
mothers. In Norway the 1-month and 4-month exclusive                                  sured as 19.2%, 15.3% and 14.5% respectively. Only
breastfeeding rates were 90% and 44% as compared to                                   Quebec illustrated a fixed rate of 10% in both surveys
63.3% and 41.4% in the present study [26]. In Quebec                                  while New Brunswick reported an increase from 8% in
(1999/2000), the exclusive breastfeeding rates were 62%                               2003 to 10.9% in our study. While no data is available
and 35% for 1 and 4 months of infant’s age [13]. The                                  in 2003 for the Northern territories, the prevalence of
Canadian 6-month exclusive breastfeeding rate is com-                                 exclusive breastfeeding in this study was the highest
parable with other developed countries. In the United                                 (21.2%) as compared to all other provinces. The differ-
States, the prevalence of exclusive breastfeeding at 6                                ences between the two studies might either be attributed
months was 11.3% [27], whereas it was 10.1% in Sweden                                 to variations in study designs, sample selection and vari-
[28] and 7% in Norway [26]. The study rate, however, is                               able definitions or to an actual decline in the rate of
lower than the rate (17%) reported earlier in Canada in                               exclusive breastfeeding in Canada.
2003 by Millar & Maclean (2005). Similarly, the provin-                                 At the multivariate analysis, years of education was
cial rates reported in the present study are lower than                               the only significant socio-economic predictor of 6-
the 2003 Canadian study [14]. The 2003 prevalence                                     month exclusive breastfeeding. The results are in accor-
rates, for example, in British Columbia, Alberta and                                  dance with the international [26,29] and Canadian
Al-Sahab et al. BMC Pediatrics 2010, 10:20                                                                                     Page 7 of 9
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Table 3 Stepwise logistic regression model for the                                With regard to maternal characteristics, living with a
potential predictors of 6-month exclusive breastfeeding                        partner, having had previous pregnancies, older age at
                                             Adjusted odds ratio               pregnancy and lower pre-pregnancy BMI was found to
                                             OR (95% CI)†                      be significantly associated with 6-month exclusive
Marital status                                                                 breastfeeding. The presence of a partner is likely to pro-
    No partner                               1                                 vide increased support for the mother, which may ease
    Have a partner                           1.61 (1.03-2.52)                  the feeding process and the choice to exclusively breast-
Moms perceived health                                                          feed for 6 months. Although studies regarding the asso-
   Excellent/very good                       1.59 (0.92-2.75)                  ciation between marital status and breastfeeding are
    Good                                     1.45 (0.82-2.57)                  inconsistent [26], the result of the present study is in
    Poor/Fair                                1                                 agreement with studies from Norway and Germany
Smoking during pregnancy                                                       [26,29]. Previous Canadian studies, however, failed to
    No                                       2.11 (1.36-3.27)                  demonstrate this association [11,14]. High parity was
    Yes                                      1                                 also found to be positively associated with 6-month
Type of setting of baby’s birth                                                exclusive breastfeeding. A dose response relationship
    Hospital or clinic                       1                                 between parity and breastfeeding has been previously
    Birthing centre                          1.20 (0.42-3.39)                  documented in the literature [26,30]. Multipara mothers
    Private home                             5.29 (2.95-9.46)                  are suggested to have increased knowledge and self con-
Type of delivery                                                               fidence from earlier breastfeeding experiences. By the
    Vaginal                                  1.25 (1.01-1.53)                  same token, young age at first pregnancy decreased the
    Caesarean                                1                                 likelihood of 6-month exclusive breastfeeding. Evidence
Baby’s admission to NICU                                                       in the literature provide consistent results of a positive
    No                                       1.51 (1.12-2.03)                  association between breastfeeding duration and maternal
    Yes                               1                                        age [11,26,29,31]. Study results are also in agreement
Mother’s employment status <6 months of delivery                               with the literature whereby maternal pre-pregnancy
    No                                       1.55 (1.14-2.10)                  BMI was found to be negatively associated with breast-
    Yes                                      1                                 feeding [32-35]. It has been postulated that heavy weight
Province‡                                                                      might interfere with prolactin production [32]. The psy-
    Eastern- Atlantic                        1                                 chological factors associated with heavy weight may also
    Eastern- Central                         1.15 (0.90-1.47)                  have an impact on breastfeeding initiation and duration
    Western- Prairies                        1.81 (1.38-2.38)                  [33].
    Western- British Columbia                1.94 (1.42-2.64)                     Evidence of the present study suggests that smoking
    Northern territories                     3.02 (2.21-4.12)                  during pregnancy decreases the likelihood of 6-month
Mother’s education level (years)             1.08 (1.05-1.12)                  exclusive breastfeeding. Lande et al. (2003) also reported
Age at first pregnancy (years)               1.05 (1.03-1.07)                  the association between exclusive breastfeeding at 4
Number of past pregnancies                   1.16 (1.09-1.23)                  months and maternal smoking status after delivery to be
BMI before pregnancy (Kg/m2)                 0.97 (0.95-0.99)                  OR = 0.40 (95% CI: 0.32, 0.50). In Canada, Albertan
† 95% CI were calculated using bootstrapping technique                         mothers who smoked during pregnancy were less likely
‡ Eastern Atlantic: Newfoundland & Labrador, Nova Scotia, Prince Edward        to continue breastfeeding for longer periods [10]. In
Island & New Brunswick; Eastern Central: Quebec & Ontario; Western Prairies:
Manitoba, Saskatchewan, & Alberta; Western British Columbia: British           Southwestern Ontario, the presence of a smoker at
Columbia; and Northern Territories: Yukon Territory, Nunavut & Northwest       home after delivery increased the risk of early breast-
Territories.
                                                                               feeding termination [12].
                                                                                  In the present study, the place of delivery was asso-
literature [9,11,14]. Nationally, Millar and Maclean                           ciated with the 6 month duration of exclusive breast-
(2005) revealed that postsecondary education was posi-                         feeding. Mothers giving birth at home were 5 times
tively associated with exclusive breastfeeding for the first                   more likely to exclusively breastfeed than mothers giving
6 months of life. Similarly in Quebec, having a univer-                        birth at hospitals. This relationship can be attributed to
sity diploma increased the odds of 4-month exclusive                           the negative influence of formula supplementation in
breastfeeding [11] and not completing high school was a                        the hospital [9]. A study in a Canadian university teach-
risk factor for early breastfeeding termination in Ontario                     ing hospital reported that 47.9% of the infants received
[9]. A higher level of maternal education seems to allow                       formula milk during hospital stay [36]. It is noteworthy,
mothers to formulate well-informed decisions regarding                         as well, that the characteristics of women giving birth at
the feeding practices used for their infant.                                   home are substantially different from their counterparts
Al-Sahab et al. BMC Pediatrics 2010, 10:20                                                                                     Page 8 of 9
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