NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®)

Rectal Cancer
Version 4.2024 — August 22, 2024

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Rectal Cancer Discussion

*Al B. Benson, III, MD/Chair † Steven Hunt, MD ¶ Steven Nurkin, MD, MS ¶

Robert H. Lurie Comprehensive Cancer Siteman Cancer Center at Barnes- Roswell Park Comprehensive Cancer Center
Center of Northwestern University Jewish Hospital and Washington
University School of Medicine Hitendra Patel, MD †
*Alan P. Venook, MD/Vice-Chair † ‡ UC San Diego Moores Cancer Center
UCSF Helen Diller Family Hisham Hussan, MD ¤
Comprehensive Cancer Center UC Davis Comprehensive Cancer Center Katrina Pedersen, MD, MS †
Mayo Clinic Comprehensive Cancer Center
Mohamed Adam, MD ¶ Kimberly L. Johung, MD, PhD §
UCSF Helen Diller Family Yale Cancer Center/Smilow Cancer Hospital Leonard Saltz, MD † ‡ Þ
Comprehensive Cancer Center Memorial Sloan Kettering Cancer Center
Nora Joseph, MD ≠
George J. Chang, MD, MS, MHCM ¶ University of Michigan Rogel Cancer Center Charles Schneider, MD †
The University of Texas MD Anderson Cancer Center Abramson Cancer Center
Natalie Kirilcuk, MD ¶ at the University of Pennsylvania
Yi-Jen Chen, MD, PhD § Stanford Cancer Institute
City of Hope National Medical Center David Shibata, MD ¶
Smitha Krishnamurthi, MD † The University of Tennessee
Kristen K. Ciombor, MD † Case Comprehensive Cancer Center/ Health Science Center
Vanderbilt-Ingram Cancer Center University Hospitals Seidman Cancer Center and
Cleveland Clinic Taussig Cancer Institute Benjamin Shogan, MD ¶
Stacey A. Cohen, MD † The UChicago Medicine
Fred Hutchinson Cancer Center Midhun Malla, MD, MS † Comprehensive Cancer Center
O’Neal Comprehensive Cancer Center at UAB
Harry S. Cooper, MD ≠ Laurie Singer ¥
Fox Chase Cancer Center Jennifer K. Maratt, MD, MS ¤ DoubleLL Productions
Indiana University Melvin and Bren Simon
Dustin Deming, MD † Comprehensive Cancer Center John M. Skibber, MD ¶
University of Wisconsin Carbone Cancer Center The University of Texas
Wells A. Messersmith, MD † MD Anderson Cancer Center
Ignacio Garrido-Laguna, MD, PhD † University of Colorado Cancer Center
Huntsman Cancer Institute Constantinos T. Sofocleous, MD, PhD ф
at the University of Utah Jeffrey Meyer, MD, MS § Memorial Sloan Kettering Cancer Center
Johns Hopkins Kimmel Cancer Center
Jean L. Grem, MD † Anna Tavakkoli, MD, MSc ¤
Fred & Pamela Buffett Cancer Center Jeffrey Meyerhardt, MD, MPH † UT Southwestern Simmons
Dana-Farber Brigham and Women’s Comprehensive Cancer Center
Carla Harmath, MD ф Cancer Center
The UChicago Medicine Comprehensive Cancer Christopher G. Willett, MD §
Center Eric D. Miller, MD, PhD § Duke Cancer Institute
The Ohio State University Comprehensive Cancer
Paul Haste, MD ф Center - James Cancer Hospital Christina Wu, MD †
Indiana University Melvin and Bren Simon and Solove Research Institute Mayo Clinic Comprehensive Cancer Center
Comprehensive Cancer Center NCCN
Mary F. Mulcahy, MD ‡ † Lisa Gurski, PhD
J. Randolph Hecht, MD † Robert H. Lurie Comprehensive Cancer Frankie Jones
UCLA Jonsson Comprehensive Cancer Center Center of Northwestern University Jenna Snedeker, MS, ASCP
Sarah Hoffe, MD §
Moffitt Cancer Center ф Diagnostic/Interventional ¥ Patient advocacy
radiology ≠ Pathology
Continue ¤ Gastroenterology § Radiotherapy/Radiation
‡ Hematology/Hematology oncology
NCCN Guidelines Panel Disclosures oncology ¶ Surgery/Surgical oncology
Þ Internal medicine * Discussion Section Writing
† Medical oncology Committee
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NCCN Guidelines Version 4.2024 NCCN Guidelines Index

Table of Contents
Rectal Cancer Discussion

NCCN Rectal Cancer Panel Members

Summary of the Guidelines Updates Find an NCCN Member Institution:
https://www.nccn.org/home/member-
Clinical Presentations and Primary Treatment: institutions.
• Pedunculated or Sessile Polyp (Adenoma) with Invasive Cancer (REC-1) NCCN Categories of Evidence and
• Workup for Rectal Cancer Without Suspected or Proven Distant Metastases/Rectal Cancer With Suspected or Consensus: All recommendations are
Proven Distant Metastases (REC-2) category 2A unless otherwise indicated.
• Staging and Treatment for Rectal Cancer Without Suspected or Proven Distant Metastases (REC-3) See NCCN Categories of Evidence
• Treatment After Transanal Local Excision of T1, N0 (REC-4) and Consensus.
• Treatment After Transabdominal Resection of T1–2, N0 (REC-5)
NCCN Categories of Preference:
• pMMR/MSS: T3, N Any; T1–2, N1–2; T4, N Any or Locally Unresectable or Medically Inoperable (REC-6)
All recommendations are considered
• pMMR/MSS: Suspected or Proven Metastatic Synchronous Adenocarcinoma (REC-7) appropriate.
• Surveillance Following Operative Management (REC-10)
• Surveillance Following Nonoperative Management (REC-10A) See NCCN Categories of Preference.
• Recurrence and Workup (REC-11)
• pMMR/MSS: Metachronous Metastases (REC-12)
• dMMR/MSI-H: T3, N Any; T1–2, N1–2; T4, N Any or Locally Unresectable or Medically Inoperable (REC-14)
• dMMR/MSI-H or POLE/POLD1 mutation: Suspected or Proven Metastatic Synchronous Adenocarcinoma (REC-15)
• dMMR/MSI-H or POLE/POLD1 mutation: Resectable Metachronous Metastases (REC-17)

Principles of Imaging (REC-A)

Principles of Pathologic and Molecular Review (REC-B)
Principles of Surgery and Locoregional Therapies (REC-C)
Principles of Perioperative Therapy (REC-D)
Principles of Radiation Therapy (REC-E)
Systemic Therapy for Advanced or Metastatic Disease (REC-F)
Principles of Survivorship (REC-G)
Principles of Nonoperative Management (REC-H)
Staging (ST-1)
Abbreviations (ABBR-1)

The NCCN Guidelines® are a statement of evidence and consensus of the authors regarding their views of currently accepted approaches to treatment.
Any clinician seeking to apply or consult the NCCN Guidelines is expected to use independent medical judgment in the context of individual clinical
circumstances to determine any patient’s care or treatment. The National Comprehensive Cancer Network® (NCCN®) makes no representations or
warranties of any kind regarding their content, use or application and disclaims any responsibility for their application or use in any way. The NCCN
Guidelines are copyrighted by National Comprehensive Cancer Network®. All rights reserved. The NCCN Guidelines and the illustrations herein may not
be reproduced in any form without the express written permission of NCCN. ©2024.
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NCCN Guidelines Version 4.2024 NCCN Guidelines Index

Table of Contents
Rectal Cancer Discussion

Terminologies in all NCCN Guidelines are being actively modified to advance the goals of equity, inclusion, and representation.
Updates in Version 4.2024 of the NCCN Guidelines for Rectal Cancer from Version 3.2024 include:
REC-C 1 of 8 through REC-C 8 of 8
• This section has been extensively revised and renamed: Principles of Surgery and Locoregional Therapies
The following sub-sections have been added under Locoregional Therapies:
◊ Image Guided Tumor Ablation
◊ Liver Tumor Ablation
◊ Lung Tumor Ablation
◊ Arterially Directed Embolic Therapy
– Hepatic Transarterial Radioembolization (TARE) with Yttrium-90 (Y-90) Microspheres
– Transarterial Chemoembolization (TACE)
◊ External Beam Radiation Therapy (EBRT)
◊ Hepatic Arterial Infusion (HAI)
References have been updated.
REC-E 1 of 2
• Principles of Radiation Therapy
Treatment Information
◊ Bullets added:
– SBRT can be used alone or in conjunction with other metastatic-directed therapies for patients with oligometastatic disease. SBRT can be
considered for larger lesions or more extensive disease, if there is sufficient uninvolved liver/lung and liver/lung radiation tolerance can be
respected. There should be no other systemic disease or it should be minimal and addressed in a comprehensive management plan. RT dosing
to consider, depending on the ability to meet normal organ constraints and underlying liver/lung function:
▪ SBRT: 30-60 Gy (typically in 3-5 fractions).
▪ Hypofractionation: 37.5-67.5 Gy in 10-15 fractions.

Continued

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Rectal Cancer Discussion

Updates in Version 3.2024 of the NCCN Guidelines for Rectal Cancer from Version 2.2024 include:
REC-F 2 of 11
• Second-line and Subsequent Therapy Options (if not previously given)
Biomarker-directed therapy
◊ NTRK gene fusion-positive: Repotrectinib added as a category 2A recommendation
REC-F 4 of 11
• Footnote added to repotrectinib: On the TRIDENT-1 trial, repotrectinib showed activity in both NTRK TKI-naïve and NTRK TKI-pretreated patients.
REC-F 8 of 11
• Regimen and dosing added for repotrectinib
REC-F 11 of 11
• Reference added: Solomon BJ, Drilon A, Lin JJ, et al. Repotrectinib in patients (pts) with NTRK fusion-positive (NTRK+) advanced solid tumors,
including NSCLC: Update from the phase I/II TRIDENT-1 trial. Annals of Oncology 2023;34:S755-S851.

Updates in Version 2.2024 of the NCCN Guidelines for Rectal Cancer from Version 1.2024 include:
REC-13
• Qualifier modified: fam-trastuzumab deruxtecan-nxki (HER2-amplified, IHC 3+) (Also for REC-F 8 of 11)
REC-B 6 of 11
• HER2 Testing
Bullet added: Fam-trastuzumab deruxtecan-nxki is only indicated in HER2-amplified tumors (IHC 3+).
REC-F 2 of 11
• Biomarker-directed therapy
Qualifier modified for fam-trastuzumab deruxtecan-nxki: HER2-amplified (IHC 3+)
REC-F 4 of 11
• Footnote t revised: Some activity was seen after a previous HER2-targeted regimen. May not be indicated in patients with underlying lung issues due to
lung toxicity (2.6% report of deaths from interstitial lung disease). May not be indicated in patients with underlying lung issues due to lung toxicity (3.5%
report of drug-related deaths from interstitial lung disease on the DESTINY-CRC01 trial). (Also for REC-13)
REC-F 11 of 11
• Reference updated: Siena S, Di Bartolomeo M, Raghav K, et al. Trastuzumab deruxtecan (DS-8201) in patients with HER2-expressing metastatic
colorectal cancer (DESTINY-CRC01): a multicentre, open-label, phase 2 trial. Lancet Oncol 2021;22:779-789. Raghav KPS, Siena S, Takashima A,
et al. Trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2-overexpressing/amplified (HER2+) metastatic colorectal cancer (mCRC): Primary
results from the multicenter, randomized, phase 2 DESTINY-CRC02 study. J Clin Oncol 2023;41:3501.

Continued
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Rectal Cancer Discussion

Updates in Version 1.2024 of the NCCN Guidelines for Rectal Cancer from Version 6.2023 include:
General
• POLE/POLD1 mutation added to dMMR/MSI-H description/header for metastatic disease throughout
• Ablation changed to 'thermal ablation' throughout
REC-1
• Findings
Sessile polyp with invasive cancer
◊ Additional step added before primary treatment: Endoscopic ultrasound (EUS) or pelvic MRI
• Primary Treatment
Arrows/pathway added to Surveillance (REC-10) after Observe for pedunculated polyp and sessile polyp
REC-2
• Rectal cancer with suspected or proven distant metastases
Workup
◊ Molecular testing language modified: Determination of tumor gene status for RAS and BRAF mutations and HER2 amplifications (individually or
as part of tissue- or blood-based next-generation sequencing [NGS] panel), Determination of tumor (MMR) or (MSI) status (if not previously done)
Molecular testing, including:
– RAS and BRAF mutations; HER2 amplifications; MMR or MSI status (if not previously done)
– Testing should be conducted as part of broad molecular profiling, which would identify rare and actionable mutations and fusions such as POLE/
POLD1, RET, and NTRK.
Footnote m modified: If known RAS/RAF mutation, HER2 testing is not indicated. Tissue- or blood-based next-generation sequencing (NGS) panels
have the ability to pick up rare and actionable mutations and fusions.
REC-3
• Primary Treatment
Stage T1, N0
◊ Pathways added:
– Non-surgical candidate
– Surgical candidate
◊ Treatment option added: Endoscopic submucosal dissection
Stage T1–2, N0
◊ Footnote added: In select cases (eg, requiring an APR), these may be treated with neoadjuvant therapy with the goal of organ preservation (as in
the bottom pathway in the above flowchart).
REC-4
• Footnote t modified: Circulating tumor DNA (ctDNA) is emerging as a prognostic marker; however, there is currently insufficient evidence to recommend
routine use of ctDNA assays outside of a clinical trial. (Also for REC-5, REC-10)
REC-6
• Footnote added: While short-course RT can be considered for preoperative radiation, for high-risk rectal cancer (clinical tumor stage cT4a or cT4b,
extramural vascular invasion (EMVI), clinical nodal stage cN2, involved mesorectal fascia (MRF), or enlarged lateral lymph nodes considered to be
metastatic), the 5-year follow-up of the RAPIDO trial now indicates a statistically higher locoregional recurrence rate (10%) in the experimental arm of
short-course RT → chemotherapy → surgery versus control arm (6%) of chemoRT → surgery → adjuvant chemotherapy.
Continued
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Rectal Cancer Discussion

Updates in Version 1.2024 of the NCCN Guidelines for Rectal Cancer from Version 6.2023 include:
REC-8
• pMMR/MSS Resectable synchronous liver only and/or lung only metastases
This page has been extensively revised by removing CRM and separating into two options: pathway with chemotherapy only, optional RT and
pathway with chemotherapy + RT
Surveillance language added: Staged or synchronous resection and/or local therapy for metastases and resection of rectal lesion or if complete
clinical response of rectal lesion, consider surveillance (REC-10A)
REC-9
• pMMR/MSS, Unresectable synchronous liver only and/or lung only metastases or medically inoperable
Surveillance language added: Immediate/delayed staged or synchronous resection and/or local therapy for metastases and resection of rectal lesion
or if complete clinical response of rectal lesion, consider surveillance (REC-10A)
Footnote hh added: Patients with BRAF mutations other than V600E may be considered for anti-EGFR therapy. (Also for REC-13, REC-F 4 of 11)
REC-10
• Surveillance Following Operative Management
Setting added: Low-risk polyps removed by polypectomy
◊ With surveillance recommendations:
– Physical exam and proctoscopy every 3–6 mo for the first 2 y
– Colonoscopy at 1 y after polypectomy
Stage II-IV
◊ Footnote added to colonoscopy: In patients with stage IV disease managed nonoperatively with complete clinical response, initiate colonoscopy
surveillance from first documentation of complete response.
Link to REC-C 3 of 5 added for surveillance following ESD
REC-10A
• Surveillance Following Nonoperative Management
Bullet 4 revised: MRI rectum every 6 months for at least up to 3 years
REC-11
• Footnote nn modified: Determination of tumor gene status for RAS and BRAF mutations and HER2 amplifications (individually or as part of tissue- or
blood-based next-generation sequencing [NGS] panel). If known RAS/RAF mutation, HER2 testing is not indicated. (Also for REC-11A)
REC-13
• pMMR/MSS, Unresectable Metachronous Metastases, Initial Treatment
RAS and BRAF WT qualifier removed and updated to HER2-amplified only for fam-trastuzumab deruxtecan-nxki
REC-15
• Footnote zz modified: Patients with dMMR/MSI-H or POLE/POLD1 mutation disease who are not candidates for immunotherapy should be treated as
recommended for pMMR/MSS disease. (Also for REC-17)
REC-16
• dMMR/MSI-H Resectable synchronous liver only and/or lung only metastases
This page has been extensively revised by removing CRM and creating one pathway for neoadjuvant treatment
Footnote added: For patients with a contraindication to checkpoint inhibitor immunotherapy, neoadjuvant chemotherapy with FOLFOX, CAPEOX, or
FOLFIRINOX is an option.
Continued
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Rectal Cancer Discussion

Updates in Version 1.2024 of the NCCN Guidelines for Rectal Cancer from Version 6.2023 include:
REC-17
• Text modified: Previous immunotherapy or contraindication
REC-B 5 of 11
• Principles of Pathologic and Molecular Review
Methods of Testing
◊ Bullet added: Repeat molecular testing should not be performed after standard cytotoxic chemotherapy as significant molecular changes are rarely
observed. Changes in the molecular profile can more commonly be seen after targeted therapies and repeat testing may be considered to guide
future targeted therapy decisions.
KRAS, NRAS, and BRAF Mutation Testing
◊ Bullet 1 modified: All patients with metastatic CRC should have tumor genotyped for RAS (KRAS and NRAS) and BRAF mutations individually or as
part of a next-generation sequencing (NGS) panel (preferred).
REC-B 6 of 11
• HER2 Testing
Bullet 3 revised: Anti-HER2 therapy with signal transduction inhibition (eg, trastuzumab/pertuzumab, trastuzumab/tucatinib, trastuzumab/lapatinib) is
only indicated in HER2-amplified tumors that are also RAS and BRAF wild-type.
REC-B 7 of 11
• New page added with information on POLE/POLD1 mutations and RET fusions
REC-B 11 of 11
• References have been updated
REC-C 1 of 5
• Principles of Surgery
Transanal Local Excision
◊ Bullets added: Local excision could be a viable option for patients who have a strong but incomplete response and are unable or unwilling to
undergo standard TME surgery. The most suitable candidates would be those meeting the near complete response (nCR) criteria as outlined in the
Principles of Nonoperative Management section (endoscopy, DRE, and MRI).
◊ Informed consent should cover discussions about potential recurrence; the need for proctectomy and stoma; increased risks of complexity,
recurrence, and complications; as well as the possibility of worsened bowel function or quality of life after subsequent radical surgery.
◊ The efficacy of local excision for patients who have achieved a clinical complete response (cCR) is not yet fully established. According to current
data, cCR, as determined through MRI, DRE, and endoscopy, typically correlates with a durable response. Therefore, implementing local excision
might introduce unnecessary risks without clear benefits. Given this uncertainty and potential for added risk, local excision is not routinely
recommended for patients who have achieved a clear cCR.
REC-C 3 of 5
• New page added on Endoscopic submucosal dissection (ESD)
REC-C 5 of 5
• References have been updated.
REC-D 1 of 2
• Principles of Perioperative Therapy
Regimen language modified for RT + capecitabine: Capecitabine 825 mg/m2 PO BID, Monday–Friday, on each day that RT is given days of radiation
treatment only, throughout the duration of RT (typically 28–30 treatment days depending on stage) Continued
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Updates in Version 1.2024 of the NCCN Guidelines for Rectal Cancer from Version 6.2023 include:
REC-E 1 of 2
• Principles of Radiation Therapy
Treatment Information
◊ Bullet 2 modified: ...(eg, coverage of external iliac lymph nodes for T4 tumors invading anterior pelvic organs or inguinal lymph nodes for low-lying
tumors involving the anal canal or avoidance of small bowel).
REC-E 2 of 2
• Target volumes
Sub-bullet 3 modified: At-risk nodal regions include mesorectal, presacral, posterior obturator nodes, and internal iliac nodes. The external iliac nodes
should also be included for T4 tumors involving anterior structures. Consider including the inguinal nodes for low-lying tumors involving the anal canal.
• RT Dosing
Short-course RT modified: ...the 5-year follow-up of the RAPIDO trial now indicates a statistically higher locoregional failure rate (10%) in the
experimental arm of short-course RT → chemotherapy → surgery versus control arm (7%) of chemoRT → surgery → adjuvant chemotherapy.
locoregional recurrence rate (10%) in the experimental arm of short-course RT → chemotherapy → surgery versus control arm (6%) of chemoRT →
surgery → adjuvant chemotherapy.
◊ Reference updated: Bahadoer R, Dijkstra E. Patterns of locoregional failure and distant metastases in patients treated for locally advanced rectal
cancer in the RAPIDO trial [abstract]. Eur J Surg Oncol 2022;48:Abstract e34. Dijkstra E, Nilsson PJ, Hospers GAP, et al. Locoregional failure
during and after short-course radiotherapy followed by chemotherapy and surgery compared to long-course chemoradiotherapy and surgery - A
five-year follow-up of the RAPIDO trial. Ann Surg 2023;278:e766-e772.
REC-F 1 of 11
• Initial Therapy
Header modified: pMMR/MSS (or dMMR/MSI-H or POLE/POLD1 mutation that is ineligible for or progression progressed on checkpoint inhibitor
immunotherapy) (Also for COL-D 2 of 11)
REC-F 2 of 11
• The subsequent systemic therapy algorithms have been extensively revised and updated to a table format.
Second-Line and Subsequent Therapy Options (if not previously given)
◊ Previous therapy without oxaliplatin or irinotecan
– Regimens added: If KRAS/NRAS/BRAF WT:
▪ FOLFIRI + (cetuximab or panitumumab)
▪ (Cetuximab or panitumumab) ± irinotecan
REC-F 4 of 11
Footnote g added: Patients with BRAF mutations other than V600E may be considered for anti-EGFR therapy.
Footnotes removed:
◊ Larotrectinib or entrectinib are treatment options for patients with metastatic colorectal cancer that is NTRK gene fusion-positive. Selpercatinib is a
treatment option for patients with metastatic colorectal cancer that is RET gene fusion-positive.
◊ Fruquintinib or regorafenib or trifluridine + tipiracil with or without bevacizumab are treatment options for patients who have progressed through all
available regimens.
◊ If not previously given.
◊ Nivolumab ± ipilimumab are FDA approved for colorectal cancer that has progressed following treatment with a fluoropyrimidine, oxaliplatin, and
irinotecan. However, a number of patients in the clinical trials had not received all three prior systemic therapies. Thirty-seven percent of patients
received nivolumab monotherapy and 24% received ipilimumab/nivolumab combination therapy in first- or second-line, and 28% and 31% of
patients had not received all three indicated prior therapies before treatment with nivolumab or ipilimumab/nivolumab, respectively.
Continued
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Rectal Cancer Discussion

Updates in Version 1.2024 of the NCCN Guidelines for Rectal Cancer from Version 6.2023 include:
REC-F 5 of 11
• Qualifier updated for all regimens with the following listing: (KRAS/NRAS/BRAF WT only)
• Regimen and dosing added for:
CAPEOX + cetuximab
CAPEOX + panitumumab
REC-F 8 of 11
• Regimen qualifiers modified for the following:
Pembrolizumab (dMMR/MSI-H only or POLE/POLD1 mutation)
Nivolumab (dMMR/MSI-H only or POLE/POLD1 mutation)
Nivolumab + ipilimumab (dMMR/MSI-H only or POLE/POLD1 mutation)
Dostarlimab-gxly (dMMR/MSI-H only or POLE/POLD1 mutation)
Fam-trastuzumab deruxtecan-nxki (HER2-amplified)
• Dose modified for fam-trastuzumab deruxtecan-nxki: 6.4 5.4 mg/kg IV on day 1, Repeat every 21 days
REC-F 11 of 11
• References have been updated.

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CLINICAL WORKUP FINDINGS PRIMARY TREATMENT

PRESENTATIONa,b
Pedunculated
polyp with
Single specimen, Observe Surveillance
invasive
completely removed cancer (REC-10)
• Pathology reviewc,d with favorable Observei
• Colonoscopy histologic featuresf or
Endoscopic Transanal local Adjuvant
• Marking of and clear margins Sessile polyp ultrasound
cancerous polyp (pT1 only) with invasive excision, if Treatment
(EUS) or appropriateg (REC-4)
site (at time of cancer pelvic MRI
Pedunculated colonoscopy or or Adjuvant
polyp or within 2 weeks if Transabdominal Treatment
sessile polyp appropriate) resectiong (REC-5)
(adenoma) with • Mismatch • Consider proctoscopyg
invasive cancer repair (MMR)/ • Chest CT and abdominal CT or MRIh
microsatellite • Complete blood count (CBC),
instability (MSI) Fragmented chemistry profile, carcinoembryonic Transanal local Adjuvant
testinge specimen or antigen (CEA) excision, if Treatment
margin cannot • Pelvic MRI with or without contrasth appropriateg (REC-4)
be assessed • EUS (if MRI is contraindicated, or
Adjuvant
or unfavorable inconclusive, or for superficial Transabdominal
Treatment
histologic lesions)h resectiong
(REC-5)
featuresf • Enterostomal therapist as indicated
for preoperative marking of site,
teaching
• FDG-PET/CT scan is not indicatedh

a All e Principles of Pathologic Review (REC-B, 5 of 11) - MSI or MMR Testing.

patients with rectal cancer should be counseled for family history. Patients f Principles of Pathologic Review (REC-B) - Endoscopically removed malignant
with suspected Lynch syndrome (LS), familial adenomatous polyposis (FAP),
and attenuated FAP, see the NCCN Guidelines for Genetic/Familial High-Risk polyp.
Assessment: Colorectal. g Principles of Surgery and Locoregional Therapies (REC-C).
b For melanoma histology, see the NCCN Guidelines for Melanoma: Cutaneous. h Principles of Imaging (REC-A).
c Confirm the presence of invasive cancer (pT1). pTis has no biological potential to i Observation may be considered, with the understanding that there is significantly
metastasize. greater incidence of adverse outcomes (residual disease, recurrent disease,
d It has not been established if molecular markers (other than MSI-H/dMMR) are mortality, or hematogenous metastasis, but not lymph node metastasis) than
useful in treatment determination (predictive markers) and prognosis. Compton pedunculated malignant polyps. See Principles of Pathologic Review (REC-B) -
CC, et al. Arch Pathol Lab Med 2000;124:979-994. Endoscopically removed malignant polyp.

Note: All recommendations are category 2A unless otherwise indicated.

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Rectal Cancer Discussion

CLINICAL WORKUP
PRESENTATIONa,b
• Biopsy
• MMR/MSI testinge
• Pathology review
• Colonoscopy
Rectal cancer • Consider proctoscopyg
without • Chest CT and abdominal CT or MRIh
suspected or REC-3
• CBC, chemistry profile, CEA
proven distant • Pelvic MRI with or without contrasth
metastasesj,k • Endorectal ultrasound (if MRI is contraindicated or inconclusive, or for superficial lesions)h
• Enterostomal therapist as indicated for preoperative marking of site, teaching
• FDG-PET/CT scan is not indicatedh
• Multidisciplinary team evaluation, including formal surgical evaluation
• Fertility risk discussion/counseling in appropriate patients
• Colonoscopy
• Consider proctoscopy
• Chest CT and abdominal CT or MRIh Proficient
• Pelvic MRI with or without contrasth MMR (pMMR)/ REC-7
• CBC, chemistry profile, CEA microsatellite
Rectal • Molecular testing, includingl,m: stable (MSS)
cancer with RAS and BRAF mutations; HER2 amplifications; MMR or MSI status (if not previously done)
suspected or Testing should be conducted as part of broad molecular profiling, which would identify rare
proven distant and actionable mutations and fusions such as POLE/POLD1, RET, and NTRK.
metastases • Biopsy, if clinically indicated Deficient
• Consider FDG-PET/CT scan (skull base to mid-thigh) if potentially surgically curable M1 MMR (dMMR)/
disease in selected casesh MSI-high
Consider MRI of liver for patients who are potentially resectable (MSI-H) or REC-15
• If potentially resectable, then multidisciplinary team evaluation, including a surgeon POLE/POLD1
experienced in the resection of hepatobiliary or lung metastases mutation

j For tools to aid optimal assessment and care of older adults with cancer, see the
a Allpatients with rectal cancer should be counseled for family history. Patients with NCCN Guidelines for Older Adult Oncology.
suspected LS, FAP, and attenuated FAP, see the NCCN Guidelines for Genetic/ k The rectum lies below a virtual line from the sacral promontory to the upper edge
Familial High-Risk Assessment: Colorectal. of the symphysis as determined by MRI.
b For melanoma histology, see the NCCN Guidelines for Melanoma: Cutaneous. l Principles of Pathologic Review (REC-B 5 of 11) - KRAS, NRAS, and BRAF
e Principles of Pathologic Review (REC-B, 5 of 11) - MSI or MMR Testing. Mutation Testing and Microsatellite Instability or Mismatch Repair Testing.
g Principles of Surgery and Locoregional Therapies (REC-C). m Tissue- or blood-based NGS panels have the ability to pick up rare and
h Principles of Imaging (REC-A). actionable mutations and fusions.
Note: All recommendations are category 2A unless otherwise indicated.

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CLINICAL CLINICAL PRIMARY TREATMENT

PRESENTATIONa,b STAGE

Non-surgical candidate Endoscopic submucosal dissectiong

T1, N0n
Endoscopic submucosal
Surgical candidate dissection (ESD)g
or Adjuvant Treatment (REC-4)
Transanal local excision, if
appropriateg
Transabdominal
T1–2, N0n,o Adjuvant Treatment (REC-5)
resectiong
Rectal cancer
without
suspected or T3, N0 low-risk, Transabdominal resectiong Surveillance (REC-10)
proven distant high rectal tumors or
metastasesj,k Treat as T3, N any below

T3, N any; pMMR/MSS Primary Treatment (REC-6)

T1–2, N1–2;
T4, N any
or Locally
unresectable
or medically
inoperable dMMR/MSI-H Primary Treatment (REC-14)

a Allpatients with rectal cancer should be counseled for family history. Patients with k The rectum lies below a virtual line from the sacral promontory to the upper edge
suspected LS, FAP, and attenuated FAP, see the NCCN Guidelines for Genetic/ of the symphysis as determined by MRI.
Familial High-Risk Assessment: Colorectal. n T1–2, N0 should be based on assessment of pelvic MRI (preferred) or endorectal
b For melanoma histology, see the NCCN Guidelines for Melanoma: Cutaneous. ultrasound.
g Principles of Surgery and Locoregional Therapies (REC-C). o In select cases (eg, requiring an APR), these may be treated with neoadjuvant
j For tools to aid optimal assessment and care of older adults with cancer, see the therapy with the goal of organ preservation (as in the bottom pathway in the
NCCN Guidelines for Older Adult Oncology. above flowchart).

Note: All recommendations are category 2A unless otherwise indicated.

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PATHOLOGIC FINDINGS AFTER ADJUVANT TREATMENTh,r,s,t

TRANSANAL LOCAL EXCISION FOR T1, N0 (UP TO 6 MO PERIOPERATIVE TREATMENT)u

pT1, NX without Surveillance

Observe
high-risk featuresp (REC-10)

Transabdominal
resectiong Adjuvant
(preferred) Treatment (REC-5)
pT1, NX with
high-risk
or
featuresp
or Consider observation
pT2, NX No evidence or Surveillance
Chemo/radiation
of disease Consider FOLFOX (REC-10)
therapy (RT)
or CAPEOX
Capecitabineq +
RT or infusional
5-fluorouracil (5- Consider FOLFOX
FU)q + RT Evidence of Transabdominal Surveillance
or
disease resectiong (REC-10)
CAPEOX

r Principles of Perioperative Therapy (REC-D).

g Principles of Surgery and Locoregional Therapies (REC-C). s Principles of Radiation Therapy (REC-E).
h Principles of Imaging (REC-A). t Circulating tumor DNA (ctDNA) is emerging as a prognostic marker; however,
p High-risk features include positive margins, lymphovascular invasion, poorly there is currently insufficient evidence to recommend routine use of ctDNA assays
differentiated tumors, or sm3 invasion (submucosal invasion to the lower third of outside of a clinical trial. De-escalation of care is not recommended based on
the submucosal level). ctDNA results. Participation in clinical trials is encouraged.
q Bolus 5-FU/leucovorin/RT is an option for patients not able to tolerate u A benefit for the addition of oxaliplatin to 5-FU/leucovorin in patients aged ≥70
capecitabine or infusional 5-FU. years has not been proven.

Note: All recommendations are category 2A unless otherwise indicated.

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PATHOLOGIC FINDINGS ADJUVANT TREATMENTh,r,s,t

AFTER TRANSABDOMINAL (UP TO 6 MO PERIOPERATIVE TREATMENT)u
RESECTION FOR T1–2, N0

pT1–2, N0, M0 Observe

Long-course chemo/RTr,s Chemotherapy

Capecitabineq or infusional 5-FUq • FOLFOX or CAPEOX
or
Chemotherapy Long-course chemo/RTr,s
FOLFOX or CAPEOX Capecitabineq or
pT3, N0, M0 or infusional 5-FUq
Consider FOLFOX or CAPEOX alone
or
Observationv Surveillance
(REC-10)

Long-course chemo/RTr,s Chemotherapy

Capecitabineq or infusional 5-FUq • FOLFOX or CAPEOX
or
pT4, N0, M0 Chemotherapy Long-course chemo/RTr,s
pT1–4, N1–2 FOLFOX or CAPEOX Capecitabineq or
or infusional 5-FUq
Consider FOLFOX or CAPEOX alone
(pT1–3, N1 only)

h Principles of Imaging (REC-A).

q Bolus 5-FU/leucovorin/RT is an option for patients not able to tolerate capecitabine or infusional 5-FU.
r Principles of Perioperative Therapy (REC-D).
s Principles of Radiation Therapy (REC-E).
t ctDNA is emerging as a prognostic marker; however, there is currently insufficient evidence to recommend routine use of ctDNA assays outside of a clinical trial. De-
escalation of care is not recommended based on ctDNA results. Participation in clinical trials is encouraged.
u A benefit for the addition of oxaliplatin to 5-FU/leucovorin in patients aged ≥70 years has not been proven.
v Observation following transabdominal resection can be considered in patients with pT3N0 rectal cancer if the tumor was well-differentiated or moderately well-
differentiated carcinoma invading less than 2 mm into the mesorectum, without lymphatic or venous vessel involvement and was located in the upper rectum. Willett
CG, et al. Dis Colon Rectum 1999;42:167-173.

Note: All recommendations are category 2A unless otherwise indicated.

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CLINICAL TOTAL NEOADJUVANT THERAPYw PRIMARY TREATMENT

STAGE
Long-course chemo/RTr,s Chemotherapy Surveillance
Transabdominal
• Capecitabineq or (12–16 wk) (REC-10)
resectiong,z,aa
infusional 5-FUq • FOLFOX or CAPEOX
or if complete clinical
or • Consider
response, consider
Short-course RTs,x,y FOLFIRINOX
surveillance (REC-10A)z
Restagingh
pMMR/MSS or
T3, N any; Long-course chemo/RTr,s Resection Systemic therapybb
T1–2, N1–2; Chemotherapy • Capecitabineq or contraindicated (REC-F 1 of 11)
T4, N any (12–16 wk) infusional 5-FUq
or Locally • FOLFOX or CAPEOX or
unresectable • Consider FOLFIRINOX Short-course RTs,x,y
or medically
inoperable or Surveillance
Tumor regression Surgeryg
>20% (REC-10)
Chemotherapy Restage with
(12–16 wk) for non-T4 sigmoidoscopy
disease eligible for ± MRI Long-course chemo/RTr,s
sphincter-sparing surgeryg • Capecitabineq or
Tumor regression Surveillance
• FOLFOX or CAPEOX infusional 5-FUq Surgeryg
<20% (REC-10)
g Principles of Surgery and Locoregional Therapies (REC-C). or
h Principles of Imaging (REC-A). Short-course RTs,x,y
q Bolus 5-FU/leucovorin/RT is an option for patients not able to tolerate capecitabine or infusional 5-FU.
r Principles of Perioperative Therapy (REC-D).
s Principles of Radiation Therapy (REC-E).
w In select cases (eg, a patient who is not a candidate for intensive therapy) neoadjuvant therapy with chemo/RT or RT alone may be considered prior to surgery.
x Evaluation for short-course RT should be in a multidisciplinary setting, with a discussion of the need for downstaging and the possibility of long-term toxicity.
y While short-course RT can be considered for preoperative radiation, for high-risk rectal cancer (clinical tumor stage cT4a or cT4b, extramural vascular invasion (EMVI),
clinical nodal stage cN2, involved mesorectal fascia (MRF), or enlarged lateral lymph nodes considered to be metastatic), the 5-year follow-up of the RAPIDO trial now
indicates a statistically higher locoregional recurrence rate (10%) in the experimental arm of short-course RT → chemotherapy → surgery versus control arm (6%) of
chemoRT → surgery → adjuvant chemotherapy.
z In those patients who achieve a complete clinical response with no evidence of residual disease on digital rectal examination (DRE), rectal MRI, and direct endoscopic
evaluation, a “watch and wait,” nonoperative (chemotherapy and/or RT) management approach may be considered in centers with experienced multidisciplinary teams.
The degree to which risk of local and/or distant failure may be increased relative to standard surgical resection has not yet been adequately characterized. Decisions for
nonoperative management (NOM) should involve a careful discussion with the patient of their risk tolerance. See Principles of Nonoperative Management (REC-H).
aa For select patients who may be candidates for intraoperative RT (IORT), see Principles of Radiation Therapy (REC-E).
bb FOLFIRINOX is not recommended in this setting.

Note: All recommendations are category 2A unless otherwise indicated.

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CLINICAL FINDINGS TREATMENT

PRESENTATION
pMMR/MSS
Primary
Resectableg treatment
(REC-8)
Synchronous
liver only and/
or lung only
metastases
Unresectableg Primary
or medically treatment
inoperable (REC-9)

Nonobstructing Systemic therapy (REC-F 1 of 11)

Suspected or
proven metastatic Synchronous
synchronous abdominal/peritoneal
adenocarcinoma metastases Resectiong,cc
(T any, N any, M1) or
Obstructed Diverting ostomy
or imminent or Systemic therapy
obstruction Bowel bypass of impending obstruction (REC-F 1 of 11)
or
Stenting (for upper rectal lesions only)

Synchronous
unresectable
metastases of Systemic therapy (REC-F 1 of 11)
other sitescc

g Principles of Surgery and Locoregional Therapies (REC-C).

cc Consider resection only if imminent risk of obstruction, significant bleeding, perforation, or other significant tumor-related symptoms.

Note: All recommendations are category 2A unless otherwise indicated.

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FINDINGS NEOADJUVANT TREATMENT

pMMR/MSS

Consider holding radiation if complete

Chemotherapy (preferred) response to neoadjuvant therapy
FOLFOX (preferred) or
or Staged or
Restagingh Short-course RTs,x synchronous
CAPEOX (preferred) or
or resection and/or
Infusional 5-FUq + pelvic RTr,s or local therapyee
5-FU/leucovorin or capecitabine capecitabineq + RTr,s for metastasesg
Resectable and resection of
synchronous rectal lesion
liver only and/ or
or lung only if complete
metastasesdd clinical response
FOLFOX (preferred) of rectal lesion,
Restagingh consider
Short-course RTs,x or (best tumor surveillance
or CAPEOX (preferred) response 8 wk (REC-10A)
Infusional 5-FUq + pelvic RTr,s or or after completion
capecitabineq + RTr,s 5-FU/leucovorin or capecitabine of RT)
or FOLFIRINOX

x Evaluation for short-course RT should be in a multidisciplinary setting, with a

g Principles of Surgery and Locoregional Therapies (REC-C). discussion of the need for downstaging and the possibility of long-term toxicity.
h Principles of Imaging (REC-A). dd If obstructing lesion, consider diversion or resection (REC-7).
q Bolus 5-FU/leucovorin/RT is an option for patients not able to tolerate ee Resection is preferred over locally ablative procedures (eg, image-guided
capecitabine or infusional 5-FU. thermal ablation or stereotactic body RT [SBRT]). However, these local
r Principles of Perioperative Therapy (REC-D). techniques can be considered for liver or lung oligometastases (REC-C and
s Principles of Radiation Therapy (REC-E). REC-E).

Note: All recommendations are category 2A unless otherwise indicated.

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FINDINGS PRIMARY TREATMENT

pMMR/MSS
Immediate/delayed staged
or synchronous resection
Consider: and/or local therapyee for
Short-course RTs,x metastasesg and resection
(preferred) of rectal lesion
Resectable or or
Infusional 5-FUq if complete clinical
FOLFIRI or FOLFOX or + pelvic RTr,s or response of rectal lesion,
CAPEOX or FOLFIRINOX capecitabineq + RTr,s consider surveillance
Unresectable
± bevacizumabff,gg (REC-10A)
synchronous
Reassess
liver only and/
or response to
or lung only Consider:
determine
metastasesdd Palliative RTs,x
FOLFIRI or FOLFOX resectabilityh Systemic
or medically Progression of or
± panitumumab or therapy
inoperable primary tumor Infusional 5-FUq
cetuximab (KRAS/NRAS/ (REC-F 1 of 11)
BRAF WT only)l,hh + pelvic RTr,s or
capecitabineq + RTr,s
Unresectable

Systemic therapy (REC-F 1 of 11)

No progression
and consider local therapys for
of primary tumor
select patients

g Principles of Surgery and Locoregional Therapies (REC-C). ee Resection is preferred over locally ablative procedures (eg, image-guided
h Principles of Imaging (REC-A). thermal ablation or SBRT). However, these local techniques can be considered
l Principles of Pathologic Review (REC-B 5 of 11) - KRAS, NRAS, and BRAF for liver or lung oligometastases (REC-C and REC-E).
Mutation Testing and Microsatellite Instability or Mismatch Repair Testing. ff There should be at least a 6-week interval between the last dose of bevacizumab
q Bolus 5-FU/leucovorin/RT is an option for patients not able to tolerate and elective surgery, and re-initiation of bevacizumab should be delayed at least
capecitabine or infusional 5-FU. 6 to 8 weeks postoperatively. There is an increased risk of stroke and other
r Principles of Perioperative Therapy (REC-D).
arterial events, especially in those aged ≥65 years. The use of bevacizumab may
s Principles of Radiation Therapy (REC-E).
interfere with wound healing.
x Evaluation for short-course RT should be in a multidisciplinary setting, with a gg An FDA-approved biosimilar is an appropriate substitute for bevacizumab.
discussion of the need for downstaging and the possibility of long-term toxicity. hh Patients with BRAF mutations other than V600E may be considered for anti-
dd If obstructing lesion, consider diversion or resection (REC-7). EGFR therapy.

Note: All recommendations are category 2A unless otherwise indicated.

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SURVEILLANCE FOLLOWING OPERATIVE MANAGEMENTh

Low-risk polyps • Physical exam and proctoscopy every 3–6 mo for the first 2 y
removed by • Colonoscopya at 1 y after polypectomy
polypectomy
• Proctoscopy (with EUS or MRI with contrast) every 3–6 mo for the first 2 y,
then every 6 mo for a total of 5 y
Transanal local
• Colonoscopya at 1 y after surgery
excision only
If advanced adenoma, repeat in 1 y
If no advanced adenoma,ii repeat in 3 y, then every 5 yjj

Stage I with full Colonoscopya at 1 y after surgery

surgical staging If advanced adenoma, repeat in 1 y
If no advanced adenoma,ii repeat in 3 y, then every 5 yjj

• History and physical examination every 3–6 mo for 2 y, then every 6 mo

for a total of 5 y
• CEAkk every 3–6 mo for 2 y, then every 6 mo for a total of 5 y
• Chest/abdomen/pelvis (C/A/P) CT
Stage II, III: every 6–12 mo (category 2B for frequency <12 mo) for a total
of 5 y Serial CEA
Stage IV: every 3–6 mo (category 2B for frequency <6 mo) x 2 y, then Workup and
Stage II–IVt elevation or
every 6–12 mo for a total of 5 y Treatment
documented
• Colonoscopya,ll in 1 y after surgery except if no preoperative colonoscopy (REC-11)
recurrence
due to obstructing lesion, colonoscopy in 3–6 mo
If advanced adenoma, repeat in 1 y
If no advanced adenoma,ii repeat in 3 y, then every 5 yjj
• FDG-PET/CT scan is not recommended
• Principles of Survivorship (REC-G)
For surveillance following ESD, see REC-C 5 of 8
a All patients with rectal cancer should be counseled for family history. Patients
with suspected LS, FAP, and attenuated FAP, see the NCCN Guidelines for
Genetic/Familial High-Risk Assessment: Colorectal. ii Villous polyp, polyp >1 cm, or high-grade dysplasia.
h Principles of Imaging (REC-A). jj Kahi CJ, et al. Gastroenterology 2016;150:758-768.
t ctDNA is emerging as a prognostic marker; however, there is currently insufficient kk If patient is a potential candidate for resection of isolated metastasis.
evidence to recommend routine use of ctDNA assays outside of a clinical trial. ll In patients with stage IV disease managed nonoperatively with complete clinical
De-escalation of care is not recommended based on ctDNA results. Participation response, initiate colonoscopy surveillance from first documentation of complete
in clinical trials is encouraged. response.

Note: All recommendations are category 2A unless otherwise indicated.

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SURVEILLANCE FOLLOWING NONOPERATIVE MANAGEMENT

• History and physical examination every 3–6 months for 2 years and then every 6 months for a total of 5 years
• CEA every 3–6 months for 2 years, then every 6 months for a total of 5 years
• DRE and proctoscopy or flexible sigmoidoscopy every 3–4 months for 2 years, then every 6 months for a total of 5 years
• MRI rectum every 6 months for up to 3 years
• CT chest/abdomen every 6–12 months for a total of 5 years, CT pelvis to be included once no longer doing MRI
• Colonoscopy at 1 year following completion of therapy
If advanced adenoma, repeat in 1 year
If no advanced adenoma, repeat in 3 years, then every 5 years
• Principles of Nonoperative Management (REC-H)

Note: All recommendations are category 2A unless otherwise indicated.

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RECURRENCE WORKUP

Negative
• Consider FDG-PET/CT
findings
• Physical exam scanh
Negative • Re-evaluate C/A/P CT
• Colonoscopy findings
Serial • C/A/P CT with with contrast in 3 mo
See treatment for Isolated
CEA contrasth Positive pelvic/anastomotic recurrence
elevation • Consider FDG- See treatment for Isolated
Positive pelvic/anastomotic recurrence findings or Documented metachronous
PET/CT scanh metastases, below
findings or Documented metachronous
metastases, below

Isolated pelvic/ pMMR/MSS REC-12

anastomotic REC-11A
recurrencemm
Resectable
Consider
Resectableg FDG- dMMR/MSI-H or POLE/POLD1 mutation REC-17
PET/CT
Documented scanh
Unresectable
metachronous pMMR/MSS REC-13
metastasesnn,oo
by CT, MRI,
and/or biopsy
Unresectable (potentially dMMR/MSI-H
convertibleg or unconvertible) or POLE/ Systemic therapy (REC-F 3 of 11)
POLD1
mutation
g Principles of Surgery and Locoregional Therapies (REC-C).
h Principles of Imaging (REC-A).
mm If previous RT given (short course or chemoradiation), see Principles of Radiation Therapy (REC-E) for further guidance.
nn Determination of tumor gene status for RAS and BRAF mutations and HER2 amplifications (individually or as part of tissue- or blood-based next-generation
sequencing [NGS] panel). See Principles of Pathologic Review (REC-B 5 of 11) - KRAS, NRAS, and BRAF Mutation Testing and Microsatellite Instability or Mismatch
Repair Testing. NGS panels have the ability to pick up rare and actionable mutations and fusions.
oo Patients should be evaluated by a multidisciplinary team including surgical consultation for potentially resectable patients.

Note: All recommendations are category 2A unless otherwise indicated.

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RECURRENCE TREATMENT
Capecitabine + RTq,r,s
Resectiong or
or Infusional 5-FU + RTq,r,s
dMMR/ Systemic therapy (REC-F 3 of 11)
MSI-H or or
POLE/ Long-course chemo/RTr,s
POLD1 (5-FU or capecitabine)q
mutation or Resectiong
Short-course RTs
Potentially
resectableg Capecitabine + RTq,r,s
Resectiong or
or Infusional 5-FU + RTq,r,s
Chemotherapy (preferred)
with FOLFOX, CAPEOX, or Long-course chemo/RTr,s
pMMR/ (5-FU or capecitabine)q
MSS FOLFIRINOX
or Short-course RTs
Isolated Resectiong ±
pelvic/ or
Long-course chemo/RTr,s Chemotherapy intraoperative RT
anastomotic (IORT)s
recurrencemm (5-FU or capecitabine)q (12–16 wk) with FOLFOX,
or Short-course RTs CAPEOX, or FOLFIRINOX

pMMR/MSS REC-F 1 of 11
Systemic therapynn
or
Unresectable dMMR/MSI-H
Chemo/RT (5-FU or capecitabine)q,r,s or POLE/POLD1 REC-F 3 of 11
or mutation
Short-course RTs

mm Ifprevious RT given (short course or chemoradiation), see Principles of

Radiation Therapy (REC-E) for further guidance.
g Principles of Surgery and Locoregional Therapies (REC-C). nn Determination of tumor gene status for RAS and BRAF mutations and HER2
q Bolus 5-FU/leucovorin/RT is an option for patients not able to tolerate amplifications (individually or as part of tissue- or blood-based NGS panel). See
capecitabine or infusional 5-FU. Principles of Pathologic Review (REC-B 5 of 11) - KRAS, NRAS, and BRAF
r Principles of Perioperative Therapy (REC-D). Mutation Testing and Microsatellite Instability or Mismatch Repair Testing. NGS
s Principles of Radiation Therapy (REC-E). panels have the ability to pick up rare and actionable mutations and fusions.

Note: All recommendations are category 2A unless otherwise indicated.

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pMMR/MSS Rectal Cancer Discussion

RESECTABLE INITIAL TREATMENT ADJUVANT TREATMENTh (UP TO 6

METACHRONOUS MO PERIOPERATIVE TREATMENT)
METASTASES
pMMR/MSS FOLFOX or CAPEOX (preferred)
Resection (preferred)pp or
and/or local therapyee Capecitabine or 5-FU/leucovorin
or
Neoadjuvant FOLFOX or CAPEOX
chemotherapy (2–3 mo) or
No previous Resection (preferred)pp Capecitabine
chemotherapy FOLFOX (preferred) or
CAPEOX (preferred) or and/or or
(Capecitabine or 5-FU/ Local therapyee 5-FU/leucovorin
leucovorin) or
(category 2B) Observation

Surveillance
Observation (preferred for previous (REC-10)
oxaliplatin-based therapy)
Resection (preferred)pp or
and/or local therapyee Systemic therapy ± biologic therapy
(REC-F 1 of 11) (category 2B for biologic
or therapy)

Previous Neoadjuvant FOLFOX or CAPEOX

chemotherapy chemotherapy or
(2–3 mo) Resection (preferred)pp Capecitabine
FOLFOX (preferred) or and/or or
CAPEOX (preferred) or Local therapyee 5-FU/leucovorin
Capecitabine or 5-FU/ or
leucovorin Observation

h Principles of Imaging (REC-A).

ee Resection is preferred over locally ablative procedures (eg, image-guided thermal ablation or SBRT). However, these local techniques can be considered for liver or
lung oligometastases (REC-C and REC-E).
pp Hepatic artery infusion ± systemic 5-FU/leucovorin (category 2B) is also an option at institutions with experience in both the surgical and medical oncologic aspects of
this procedure.

Note: All recommendations are category 2A unless otherwise indicated.

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pMMR/MSS INITIAL TREATMENTqq ADJUVANT TREATMENTh

UNRESECTABLE (UP TO 6 MO
METACHRONOUS PERIOPERATIVE
(FOLFIRI or irinotecan) ±
METASTASES TREATMENT)
(bevacizumabrr [preferred] or ziv-
aflibercept
or ramucirumab)ss Systemic therapy ±
or Resectionpp biologic therapyww
(FOLFIRI or irinotecan) ± Converted to (preferred) (REC-F) Surveillance
(cetuximab or panitumumab) resectable and/or (category 2B for (REC-10)
local biologic therapy)
(KRAS/NRAS/BRAF WT gene Re-evaluateh
• Previous
only)l,hh therapyee or
FOLFOX/CAPEOX for conversion
or to resectable Observation
within past 12 mo
Encorafenib + (cetuximab or diseaseg
panitumumab) (BRAF V600E every 2 mo if
mutation positive)l conversion to
or resectability is
Trastuzumabtt + (pertuzumab, a reasonable
lapatinib, or tucatinib) (HER2- goal
Systemic therapy (REC-F)
amplified and RAS and BRAF Remains
and consider local therapy for
WT)l or fam-trastuzumab unresectable
select patients
deruxtecan-nxkiuu (HER2-
amplified, IHC 3+)l
or
• Previous (Sotorasib or adagrasib)vv +
hh
Patients with BRAF mutations other than V600E may be considered for anti-EGFR therapy.
FOLFOX/CAPEOX (cetuximab or panitumumab)
pp
Hepatic artery infusion ± systemic 5-FU/leucovorin (category 2B) is also an option at
>12 mo (KRAS G12C mutation positive)l institutions with experience in both the surgical and medical oncologic aspects of this
• Previous 5-FU/LV procedure.
qq For infection risk, monitoring, and prophylaxis recommendations for targeted therapies, see
or capecitabine Systemic therapy
• No previous INF-A in the NCCN Guidelines for Prevention and Treatment of Cancer-Related Infections.
(REC-F 1 of 11) rr An FDA-approved biosimilar is an appropriate substitute for bevacizumab.
chemotherapy ss Bevacizumab is the preferred anti-angiogenic agent based on toxicity and/or cost.
tt An FDA-approved biosimilar is an appropriate substitute for trastuzumab.
g Principles of Surgery and Locoregional Therapies (REC-C). uu Some activity was seen after a previous HER2-targeted regimen. May not be indicated in
h Principles of Imaging (REC-A). patients with underlying lung issues due to lung toxicity (3.5% report of drug-related deaths
l Principles of Pathologic Review (REC-B 5 of 11) - KRAS, NRAS, and BRAF Mutation from interstitial lung disease on the DESTINY-CRC01 trial).
Testing and Microsatellite Instability or Mismatch Repair Testing. vv If patient is unable to tolerate EGFR inhibitor due to toxicity, single-agent adagrasib or
ee Resection is preferred over locally ablative procedures (eg, image-guided thermal sotorasib can be considered.
ablation or SBRT). However, these local techniques can be considered for liver or lung ww Biologic therapy is only appropriate for continuation of favorable response from conversion
oligometastases (REC-C and REC-E). therapy.

Note: All recommendations are category 2A unless otherwise indicated.

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dMMR/MSI-H Rectal Cancer Discussion

CLINICAL NEOADJUVANT/DEFINITIVE
STAGE IMMUNOTHERAPY
(PREFERRED) Complete Surveillance
clinical Surveillance (REC-10A) (REC-10)
Checkpoint response or
inhibitor Re-evaluate Transabdominal
Consider FOLFOX
immunotherapy for disease resectiong,z,aa Surveillance
Long-course or CAPEOX (REC-10)
up to 6 monthsxx status or if complete
Persistent chemo/RTr,s (12–16 wk)
• Dostarlimab-gxly every 2–3 clinical response,
months disease at • Capecitabineq consider
or or infusional
dMMR/MSI-H 6 months surveillance
• Nivolumab 5-FUq
T3, N any; or (REC-10A)z
T1–2, N1–2; or
• Pembrolizumab Short-course
T4, N any Resection Systemic therapy (REC-F 1 of 11)
or Locally RT
contraindicated
unresectable
or medically
inoperable TOTAL NEOADJUVANT THERAPYyy Transabdominal Surveillance
resectiong,z,aa (REC-10)
Long-course chemo/RTr,s Chemotherapy or if complete clinical
• Capecitabineq or (12–16 wk) response, consider
infusional 5-FUq • FOLFOX or CAPEOX Restagingh surveillance (REC-10A)z
or • Consider
Short-course RTs,x FOLFIRINOX Resection Systemic therapybb
contraindicated (REC-F 1 of 11)

g Principles of Surgery and Locoregional Therapies (REC-C).

h Principles of Imaging (REC-A).
q Bolus 5-FU/leucovorin/RT is an option for patients not able to tolerate capecitabine or infusional 5-FU.
r Principles of Perioperative Therapy (REC-D).
s Principles of Radiation Therapy (REC-E).
x Evaluation for short-course RT should be in a multidisciplinary setting, with a discussion of the need for downstaging and the possibility of long-term toxicity.
z In those patients who achieve a complete clinical response with no evidence of residual disease on DRE, rectal MRI, and direct endoscopic evaluation, a “watch and wait,” nonoperative
(chemotherapy and/or RT) management approach may be considered in centers with experienced multidisciplinary teams. The degree to which risk of local and/or distant failure may be
increased relative to standard surgical resection has not yet been adequately characterized. Decisions for NOM should involve a careful discussion with the patient of their risk tolerance. See
Principles of Nonoperative Management (REC-H).
aa For select patients who may be candidates for IORT, see Principles of Radiation Therapy (REC-E).
bb FOLFIRINOX is not recommended in this setting.
xx If no previous treatment with a checkpoint inhibitor.
yy In select cases (eg, a patient who is not a candidate for intensive therapy) neoadjuvant therapy with chemo/RT or RT alone may be considered prior to surgery.

Note: All recommendations are category 2A unless otherwise indicated.

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CLINICAL FINDINGS
PRESENTATION
dMMR/MSI-H or
POLE/POLD1
mutation Resectable
synchronous liver
Primary treatment (REC-16)
only and/or lung
only metastases

Nonobstructing Systemic therapy (REC-F 3 of 11)

Suspected or
proven metastatic Synchronous
synchronous abdominal/peritoneal
adenocarcinoma metastases Resectiong,cc
(T any, N any, M1) or
Obstructed Diverting ostomy
or imminent or Systemic therapy
obstruction Bowel bypass of impending obstruction (REC-F 3 of 11)
or
Stenting (for upper rectal lesions only)

Synchronous
unresectable Systemic therapy (REC-F 3 of 11)
metastasescc,zz

g Principles of Surgery and Locoregional Therapies (REC-C).

cc Consider resection only if imminent risk of obstruction, significant bleeding, perforation, or other significant tumor-related symptoms.
zz Patients with dMMR/MSI-H or POLE/POLD1 mutation disease who are not candidates for immunotherapy should be treated as recommended for pMMR/MSS
disease. See NCCN Guidelines for Management of Immunotherapy-Related Toxicities.

Note: All recommendations are category 2A unless otherwise indicated.

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FINDINGS NEOADJUVANT TREATMENT

dMMR/MSI-H
or POLE/
POLD1
mutation Staged or
synchronous
resection and/or
local therapyee
Consider holding radiation if complete for metastasesg
response to neoadjuvant therapy and resection of
Resectable rectal lesion
synchronous Checkpoint inhibitor immunotherapy or
liver only and/ Restagingh Short-course RTs,x (preferred)
(preferred)xx,aaa,bbb,ccc or
or lung only or
metastasesdd Infusional 5-FUq + pelvic RTr,s or
capecitabineq + RTr,s Surveillance
(REC-10A)
if complete
response to
immunotherapy

ee Resection is preferred over locally ablative procedures (eg, image-guided

thermal ablation or SBRT). However, these local techniques can be considered for
g Principles of Surgery and Locoregional Therapies (REC-C). liver or lung oligometastases (REC-C and REC-E).
h Principles of Imaging (REC-A). xx If no previous treatment with a checkpoint inhibitor.
q Bolus 5-FU/leucovorin/RT is an option for patients not able to tolerate aaa Checkpoint inhibitor therapy options include: nivolumab ± ipilimumab,
capecitabine or infusional 5-FU. pembrolizumab, or dostarlimab-gxly.
r Principles of Perioperative Therapy (REC-D). bbb Data are limited and the risk of early progression may be higher than with
s Principles of Radiation Therapy (REC-E). chemotherapy. Andre T, et al. N Engl J Med 2020;383:2207-2218.
x Evaluation for short-course RT should be in a multidisciplinary setting, with a ccc For patients with a contraindication to checkpoint inhibitor immunotherapy,
discussion of the need for downstaging and the possibility of long-term toxicity. neoadjuvant chemotherapy with FOLFOX, CAPEOX, or FOLFIRINOX is an
dd If obstructing lesion, consider diversion or resection (REC-7). option.

Note: All recommendations are category 2A unless otherwise indicated.

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dMMR/MSI-H or INITIAL TREATMENTzz ADJUVANT TREATMENTh (UP TO 6

POLE/POLD1 MO PERIOPERATIVE TREATMENT)
mutation
RESECTABLE
METACHRONOUS FOLFOX or CAPEOX (preferred)
METASTASES Resection (preferred)pp or
and/or local therapyee Capecitabine or 5-FU/leucovorin

No previous or
immunotherapy Observation (REC-10A)

Checkpoint inhibitor or
immunotherapyaaa Resectionpp
and/or
Local therapyee
Surveillance
Observation (preferred for previous (REC-10)
oxaliplatin-based therapy)
Resection (preferred)pp or
and/or local therapyee Systemic therapy ± biologic therapy
(REC-F) (category 2B for biologic
or therapy)
Previous
immunotherapy Neoadjuvant FOLFOX or CAPEOX
or chemotherapy (2–3 mo) or
contraindication FOLFOX (preferred) or Resection (preferred)pp Capecitabine
CAPEOX (preferred) or and/or or
Capecitabine or 5-FU/ Local therapyee 5-FU/leucovorin
leucovorin or
Observation

h Principles of Imaging (REC-A).

ee Resection is preferred over locally ablative procedures (eg, image-guided zz Patients with dMMR/MSI-H or POLE/POLD1 mutation disease who are not
thermal ablation or SBRT). However, these local techniques can be considered candidates for immunotherapy should be treated as recommended for pMMR/
for liver or lung oligometastases (REC-C and REC-E). MSS disease. See NCCN Guidelines for Management of Immunotherapy-Related
pp Hepatic artery infusion ± systemic 5-FU/leucovorin (category 2B) is also an Toxicities.
option at institutions with experience in both the surgical and medical oncologic aaa Checkpoint inhibitor therapy options include: nivolumab ± ipilimumab,
aspects of this procedure. pembrolizumab, or dostarlimab-gxly.

Note: All recommendations are category 2A unless otherwise indicated.

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Rectal Cancer Discussion

PRINCIPLES OF IMAGING1-3
Initial Workup/Staging
• Chest CT and abdominal CT or MRI
Evaluate local extent of tumor or infiltration into surrounding structures.
Assess for distant metastatic disease to lungs, thoracic and abdominal lymph nodes, liver, peritoneal cavity, and other organs.
CT performed with intravenous (IV) iodinated contrast and oral contrast material unless contraindicated.
IV contrast is not required for the chest CT (but usually given if performed with abdominal CT scan).
If IV iodinated contrast material is contraindicated because of significant contrast allergy, then MRI examination of the abdomen with IV
gadolinium-based contrast agent (GBCA) can be obtained instead. In patients with chronic renal failure (glomerular filtration rate [GFR] <30
mL/min) who are not on dialysis, IV iodinated contrast material is also contraindicated, and IV GBCA can be administered in select cases
using gadofosveset trisodium, gadoxetate disodium, gadobenate dimeglumine, or gadoteridol.
If iodinated and gadolinium contrast are both contraindicated due to significant allergy or chronic renal failure without dialysis, then
consider MRI without IV contrast or consider FDG-PET/CT imaging.
• Pelvic MRI with or without contrast or endorectal ultrasound (only if MRI is contraindicated [eg, pacemaker])
[See Pelvic MRI Requirements (REC-A 3 of 4) and Reporting (REC-A 4 of 4)]
Assess T and N stage of the primary rectal tumor.
Pelvic MRI or CT can be used for workup of synchronous metastatic disease.
Pelvic MRI can be performed with or without IV gadolinium contrast per institutional preferences.
Pelvic MRI may not be required for local staging if tumor is known to be definite T1 or if patient is not a candidate for primary tumor
resection (eg, widespread metastases, plan for permanent colonic diversion).
The rectum lies below a virtual line from the sacral promontory to the upper edge of the symphysis as determined by MRI.
• FDG-PET/CT is not routinely indicated.
FDG-PET/CT does not supplant a contrast-enhanced diagnostic CT or MRI and should only be used to evaluate an equivocal finding on a
contrast-enhanced CT or MRI scan or in patients with strong contraindications to IV contrast administration.
• Consider FDG-PET/CT (skull base to mid-thigh):
If potentially surgically curable M1 disease in selected cases.
In patients considered for image-guided liver-directed therapies for liver metastases (ie, thermal ablation, radioembolization).4-8
• If liver-directed therapy or surgery is contemplated, a hepatic MRI with IV routine extracellular or hepatobiliary GBCA is preferred over CT to
assess exact number and distribution of metastatic foci for local treatment planning.

Restaging and Follow-up/Surveillance (REC-A 2 of 4)

References (REC-A 2 of 4)

Continued

Note: All recommendations are category 2A unless otherwise indicated.

REC-A
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PRINCIPLES OF IMAGING1-3
Restaging
• Chest CT and abdominal CT or MRI and pelvic MRI
Prior to surgery for restaging
Prior to adjuvant treatment to assess response to primary therapy or resection
During re-evaluation of conversion to resectable disease
• FDG-PET/CT is not indicated.
Follow-up/Surveillance
• Stage I disease:
Imaging is not routinely indicated and should only be based on symptoms and clinical concern for recurrent/metastatic disease.
• Stage II & III disease:
C/A/P CT every 6 to 12 months (category 2B for frequency <12 months) for a total of 5 years.
MRI or EUS of the rectum every 3 to 6 months for 2 years, then every 6 months for a total of 5 years (for patients with transanal local excision
only).
FDG-PET/CT examination is not recommended.
• Stage IV disease:
C/A/P CT every 3 to 6 months (category 2B for frequency <6 months) x 2 years, then every 6 to 12 months for a total of 5 years.
MRI or EUS of the rectum every 3 to 6 months for 2 years, then every 6 months for a total of 5 years (for patients with transanal excision only).
• FDG-PET/CT is not indicated with the exception of selected patients who are considered for image-guided liver-directed therapies for hepatic
metastases (ie, thermal ablation, radioembolization) or serial CEA elevation during follow-up.

1 Niekel MC, Bipat S, Stoker J. Diagnostic imaging of colorectal liver metastases with CT, MR imaging, FDG PET, and/or FDG PET/CT: a meta-analysis of prospective
studies including patients who have not previously undergone treatment. Radiology 2010;257:674-684.
2 van Kessel CS, Buckens CF, van den Bosch MA, et al. Preoperative imaging of colorectal liver metastases after neoadjuvant chemotherapy: a meta-analysis. Ann Surg
Oncol 2012;19:2805-2813.
3 ACR manual on contrast media v10.3 https://www.acr.org/-/media/ACR/Files/Clinical-Resources/Contrast_Media.pdf. Accessed May 25, 2017.
4 Mauri G, Gennaro N, De Beni S, et al. Real-time US-18FDG-PET/CT image fusion for guidance of thermal ablation of 18FDG-PET-positive liver metastases: the added
value of contrast enhancement. Cardiovasc Intervent Radiol 2019;42:60-68.
5 Sahin DA, Agcaoglu O, Chretien C, et al. The utility of PET/CT in the management of patients with colorectal liver metastases undergoing laparoscopic radiofrequency
thermal ablation. Ann Surg Oncol 2012;19:850-855.
6 Shady W, Kishore S, Gavane S, et al. Metabolic tumor volume and total lesion glycolysis on FDG-PET/CT can predict overall survival after (90)Y radioembolization of
colorectal liver metastases: a comparison with SUVmax, SUVpeak, and RECIST 1.0. Eur J Radiol 2016;85:1224-1231.
7 Shady W, Sotirchos VS, Do RK, et al. Surrogate imaging biomarkers of response of colorectal liver metastases after salvage radioembolization using 90Y-loaded resin
microspheres. AJR Am J Roentgenol 2016;207:661-670.
8 Cornelis FH, Petre EN, Vakiani E, et al. Immediate postablation 18 F-FDG injection and corresponding SUV are surrogate biomarkers of local tumor progression after
thermal ablation of colorectal carcinoma liver metastases. J Nucl Med 2018;59:1360-1365. Continued

Note: All recommendations are category 2A unless otherwise indicated.

REC-A
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Rectal Cancer Discussion

PRINCIPLES OF IMAGING
Pelvic MRI Requirements3
Patient Preparation
Rectal distension with gel Not a requirement. There is controversy on the effect of rectal distension on accurately assessing the
distance of tumor to mesorectal fascia (MRF)
Use of spasmolytic agents Not a requirement. Can help decrease bowel movement-related artifacts if needed

MRI Hardware Requirement

Magnet strength Minimum requirement 1.5 T
1.0 T magnets produce limited signal and should be avoided when possible
Coil External surface body coil adequate and preferred to endorectal coils

MRI Sequences
2D high-resolution T2-weighted • Slice thickness 1–3 mm (no more than 4 mm). 3D T2-weighted sequences are not adequate
substitutes
• Main sequences for T staging and detection of pathologic lymph nodes
• Axial, sagittal, and coronal plane to assess extent and relationship to all surrounding structures
• Axial and coronal slices should be angulated along the short (perpendicular) and long (parallel) axis
of tumor for tumors in the middle and upper part of the rectum and along the anal canal for low rectal
tumors
T1-weighted without contrast Not a requirement for staging. May be helpful in assessing other pelvic organs and/or pathologies

Diffusion-weighted imaging (DWI) Not a requirement for T staging or detection of pathologic lymph node. Helpful in assessing treatment
response after neoadjuvant therapy (assessing the yT-stage)
T1-weighted with contrast Not a requirement for staginga

a IV contrast can be administered (after completion of non-contrast scans) if dynamic contrast-enhanced (DCE) MRI and/or perfusion assessment is needed for tumor
response evaluation, currently performed primarily in investigational setting.
3 ACR manual on contrast media v10.3 https://www.acr.org/-/media/ACR/Files/Clinical-Resources/Contrast_Media.pdf. Accessed May 25, 2017. Continued

Note: All recommendations are category 2A unless otherwise indicated.

REC-A
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PRINCIPLES OF IMAGING
Pelvic MRI Reporting3
At presentation • Distance from the anal verge or anorectal junction to the lower aspect of the tumor
(before • Tumor length
neoadjuvant • T-stage of primary mass
therapy) • Tumor deposits within the mesorectum
• Involvement of the MRF and the smallest distance (mm) between the tumor and the MRF and its locationb
• N-stage
• Presence/absence of suspicious extramesorectal lymph nodes
• Additional findings that can be provided in synoptic report:
The circumferential location of the tumor
In T3 tumor, the extent (mm) of extramural growth or depth of invasion
Number of suspicious lymph nodes
Presence/absence of extramural vascular invasion (EMVI)
Morphologic pattern of tumor growth (eg, annular, polypoid, mucinous, ulcerated, perforated)
After neoadjuvant • Distance from the anal verge or anorectal junction to the lower aspect of the remaining tumor
therapy • Tumor length
• Presence/absence of a residual tumor (high signal on T2-weighted images)
• Presence/absence of fibrosis (low signal on T2-weighted images)
• yT-stage and any remaining tumor deposits within the mesorectum
• yN-stage and number of remaining suspicious lymph nodes
• Presence of any remaining suspicious extramesorectal lymph nodes
• Persistent involvement/regression from the MRFb
• The smallest distance (mm) between the remaining tumor and the MRF and its location
• Additional findings that can be provided in synoptic report:
The circumferential location of the remaining tumor within the wall
In the case of a yT3 tumor, the extent (mm) of extramural growth
The morphologic pattern of tumor growth
Presence/absence of EMVI (no clear consensus on reporting this finding)

b Circumferential resection margin (CRM) measured at the closest distance of the tumor to the MRF. Clear CRM: Greater than 1 mm from MRF and levator muscles
and not invading into the intersphincteric plane. Involved CRM: within 1 mm of MRF; or, for lower third rectal tumors, within 1 mm from levator muscle; or, for anal
canal lesions, invasion into or beyond the intersphincteric plane.
3 ACR manual on contrast media v10.3 https://www.acr.org/-/media/ACR/Files/Clinical-Resources/Contrast_Media.pdf. Accessed May 25, 2017.

Note: All recommendations are category 2A unless otherwise indicated.

REC-A
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PRINCIPLES OF PATHOLOGIC AND MOLECULAR REVIEW

Endoscopically Removed Malignant Polyps
• A malignant polyp is defined as one with cancer invading through the muscularis mucosae and into the submucosa (pT1). pTis is not
considered to be a “malignant polyp.”
• Favorable histopathologic features: grade 1 or 2, no angiolymphatic invasion, and negative margin of resection. There is no consensus as to
the definition of what constitutes a positive margin of resection. A positive margin has been defined as: 1) tumor <1 mm from the transected
margin; 2) tumor <2 mm from the transected margin; and 3) tumor cells present within the diathermy of the transected margin.1-4
• Unfavorable histologic features grade 3 or 4, angiolymphatic invasion, or a “positive margin.” See above for definition of a positive margin.
In several studies, tumor budding has been shown to be an adverse histologic feature associated with adverse outcome and may preclude
polypectomy as an adequate treatment of endoscopically removed malignant polyps.
• There is controversy as to whether malignant colorectal polyps with a sessile configuration can be successfully treated by endoscopic
removal. The literature seems to indicate that endoscopically removed sessile malignant polyps have a significantly greater incidence of
adverse outcome (residual disease, recurrent disease, mortality, or hematogenous metastasis, but not lymph node metastasis) than do
polypoid malignant polyps. However, when one looks closely at the data, configuration by itself is not a significant variable for adverse
outcome, and endoscopically removed malignant sessile polyps with grade I or II histology, negative margin, and no lymphovascular
invasion can be successfully treated with endoscopic polypectomy.3-7

Transanal Local Excision

• Favorable histopathologic features: <3 cm size, pT1, grade 1 or 2, no lymphatic or venous invasion, or negative margins.8,9
• Unfavorable histopathologic features: >3 cm in size, >pT1, with grade 3, or lymphovascular invasion, positive margin, tumor budding, or sm3
(lower one third of the submucosa) depth of tumor invasion.8-10

Rectal Cancer Appropriate for Resection

• Histologic confirmation of primary malignant rectal neoplasm.
• The rectum lies below a virtual line from the sacral promontory to the upper edge of the symphysis as determined by MRI.

Pathologic Stage on REC-B (2 of 11)

Lymph Node Evaluation on REC-B (4 of 11)
Sentinel Lymph Node Evaluation on REC-B (4 of 11)
KRAS, NRAS, and BRAF Mutation Testing and Microsatellite Instability or Mismatch Repair Testing on REC-B (5 of 11)
HER2 Testing and NTRK Fusions on REC-B (6 of 11)
References

Note: All recommendations are category 2A unless otherwise indicated.

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PRINCIPLES OF PATHOLOGIC AND MOLECULAR REVIEW

Pathologic Stage
• The following parameters should be reported:
Grade of the cancer
Depth of penetration (pT), the pT stage, is based on viable tumor. Acellular mucin pools are not considered to be residual tumor in those
patients treated with neoadjuvant therapy.
Number of lymph nodes evaluated and number positive (N). Acellular mucin pools are not considered to be residual tumor in those patients
treated with neoadjuvant therapy.
Status of proximal, distal, circumferential (radial), and mesenteric margins11,12
Circumferential resection margin (CRM)13-17
Neoadjuvant treatment effect15,16,18-20
Lymphovascular invasion15,16,21
Perineural invasion (PNI)22-24
Tumor deposits25,26
• CRM - A positive CRM is defined as tumor ≤1 mm from the margin. This assessment includes both tumor within a lymph node as well as
direct tumor extension. However, if CRM positivity is based solely on intranodal tumor, it should be stated in the pathology report. A positive
CRM is a more powerful predictor of local recurrence in patients treated with neoadjuvant therapy. A positive CRM secondary to lymph node
metastasis in some studies has been associated with lower recurrence rates than by direct extension.13-17
• Neoadjuvant treatment effect - The most recent College of American Pathologists (CAP) Guidelines on examination specimens of the rectum
and the AJCC Cancer Staging Manual, Eighth Edition require commenting on treatment effect after neoadjuvant therapy. The minimum
requirement is:
Treatment effect present.
No definitive response identified.
• The system used to grade tumor response as recommended by the AJCC Cancer Staging Manual, Eighth Edition and the CAP Guidelines is
that as modified from Ryan R, et al. Histopathology 2005;47:141-146 and Gavioli M, et al. Dis Colon Rectum 2005;48:1851-1857.
0 - Complete response: No remaining viable cancer cells.
1 - Moderate response: Only small clusters or single cancer cells remaining.
2 - Minimal response: Residual cancer remaining, but with predominant fibrosis.
3 - Poor response: Minimal or no tumor kill; extensive residual cancer.
According to the CAP, it is optional to grade the tumor response to treatment. However, the NCCN Rectal Cancer Guidelines Panel
recommends grading tumor response. Other grading systems that are used are referenced.15,16,18-20

Pathologic Stage (continued) on REC-B (3 of 11)

Lymph Node Evaluation on REC-B (4 of 11)
Endoscopically Removed Malignant Polyps, Transanal Local Excision, Rectal Cancer Appropriate for Resection on REC-B (1 of 11)
KRAS, NRAS, and BRAF Mutation Testing and Microsatellite Instability or Mismatch Repair Testing on REC-B (5 of 11)
HER2 Testing and NTRK Fusions on REC-B (6 of 11)
References

Note: All recommendations are category 2A unless otherwise indicated.

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PRINCIPLES OF PATHOLOGIC AND MOLECULAR REVIEW

Pathologic Stage (continued)
• PNI - The presence of PNI is associated with a significantly worse prognosis. In multivariate analysis, PNI has been shown to be an
independent prognostic factor for cancer-specific, overall, and disease-free survival. For stage II rectal cancer, those with PNI have a
significantly worse 5-year disease-free survival compared to those without PNI (29% vs. 82%; P = .0005). In stage III rectal cancer, those with
PNI have a significantly worse prognosis.21-26
• Tumor deposits - Irregular discrete tumor deposits in pericolic or perirectal fat away from the leading edge of the tumor and showing no
evidence of residual lymph node tissue, but within the lymphatic drainage of the primary carcinoma, are considered to be tumor deposits or
satellite nodules and are not counted as lymph nodes replaced by tumor. Most examples are due to lymphovascular invasion or, more rarely,
PNI. Because these tumor deposits are associated with reduced disease-free and overall survival, their number should be recorded in the
surgical pathology report.
• Tumor budding - In recent years, tumor budding has been identified as a new prognostic factor in colon cancer. Recently, there was an
international consensus conference on tumor budding reporting.27 A tumor bud is defined as a single cell or a cluster of ≤4 cells detected
by hematoxylin and eosin (H&E) at the advancing edge of the invasive carcinoma. The total number of buds should be reported from a
selected hot spot measuring 0.785 mm (20x ocular in most microscopes/via a conversion factor). Budding is separated into three tiers: low
tier (0–4 buds), intermediate tier (5–9 buds), and high tier (10 or more buds). Two recent studies28,29 using this scoring system have shown
tumor budding to be an independent prognostic factor for stage II colon cancer. An ASCO guideline for stage II colon cancer designates
tumor budding as an adverse (high-risk) factor.30 Several studies have shown that high-tier tumor budding in pT1 colorectal cancers (CRCs),
including malignant polyps, is associated with an increased risk of lymph node metastasis; however, methodologies for assessing tumor
budding and grade were not uniform.31-35

Endoscopically Removed Malignant Polyps, Transanal Local Excision, Rectal Cancer Appropriate for Resection on REC-B (1 of 11)
Pathologic Stage on REC-B (2 of 11)
Lymph Node Evaluation on REC-B (4 of 11)
KRAS, NRAS, and BRAF Mutation Testing and Microsatellite Instability or Mismatch Repair Testing on REC-B (5 of 11)
HER2 Testing and NTRK Fusions on REC-B (6 of 11)
References

Note: All recommendations are category 2A unless otherwise indicated.

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PRINCIPLES OF PATHOLOGIC AND MOLECULAR REVIEW

Lymph Node Evaluation
• The AJCC and CAP recommend examination of a minimum of 12 lymph nodes to accurately stage rectal cancer.11,12,36 Sampling of 12 lymph
nodes may not be achievable in patients who received preoperative chemotherapy. The literature lacks consensus as to what is the minimum
number of lymph nodes to accurately identify stage II cancer. The minimum number of nodes has been reported as >7, >9, >13, >20, and
>30.36-44 Most of these studies have combined rectal and colon cancers and reflect those cases with surgery as the initial treatment. Two
studies confined only to rectal cancer have reported 14 and >10 lymph nodes as the minimum number to accurately identify stage II rectal
cancer.40,43 The number of lymph nodes retrieved can vary with patient age, gender, tumor grade, and tumor site.37 For stage II (pN0) colon
cancer, if fewer than 12 lymph nodes are initially identified, it is recommended that the pathologist go back to the specimen and resubmit
more tissue of potential lymph nodes. If 12 lymph nodes are still not identified, a comment in the report should indicate that an extensive
search for lymph nodes was undertaken. The mean number of lymph nodes retrieved from rectal cancers treated with neoadjuvant therapy
is significantly less than those treated by surgery alone (13 vs. 19, P < .05; 7 vs. 10, P < .001).45,46 If 12 lymph nodes is considered the
number needed to accurately stage stage II tumors, then only 20% of patients treated with neoadjuvant therapy had adequate lymph node
sampling.46 To date, the number of lymph nodes needed to accurately stage neoadjuvant-treated cases is unknown. However, it is not
known what the clinical significance of this is in the neoadjuvant setting, as postoperative therapy is indicated in all patients who receive
preoperative therapy regardless of the surgical pathology results.

Sentinel Lymph Node and Detection of Micrometastasis by Immunohistochemistry (IHC)

Examination of the lymph nodes (sentinel or routine) by intense histologic and/or immunohistochemical investigation helps to detect the
presence of metastatic disease. The detection of single cells by IHC or by multiple H&E levels and/or clumps of tumor cells <0.2 mm are
considered isolated tumor cells (pN0).47 The AJCC Cancer Staging Manual, Eighth Edition47 defines clumps of tumor cells ≥0.2 mm but ≤2 mm
in diameter or clusters of 10 to 20 tumor cells as micrometastasis and recommends that these micrometastases be considered as standard
positive lymph nodes (pN+).
• At the present time the use of sentinel lymph nodes and detection of isolated tumor cells by IHC alone should be considered investigational,
and results should be used with caution in clinical management decisions.48-55 Some studies have shown that the detection of IHC
cytokeratin-positive cells in stage II (N0) colon cancer (defined by H&E) has a worse prognosis, while others have not shown this survival
difference. In some of these studies, what are presently defined as isolated tumor cells were considered to be micrometastases.51-55

Evaluation of Mesorectum (total mesorectal excision, TME)

• The pathologist should evaluate the quality (completeness) of the mesorectum (only for low rectal cancer - distal 2/3).56-58

Endoscopically Removed Malignant Polyps, Transanal Local Excision, Rectal Cancer Appropriate for Resection on REC-B (1 of 11)
Pathologic Stage on REC-B (2 of 11)
KRAS, NRAS, and BRAF Mutation Testing and Microsatellite Instability or Mismatch Repair Testing on REC-B (5 of 11)
HER2 Testing and NTRK Fusions on REC-B (6 of 11)
References

Note: All recommendations are category 2A unless otherwise indicated.

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Methods of Testing
• The testing can be performed on formalin-fixed paraffin-embedded tissue (preferred) or blood-based assay.
• Repeat molecular testing should not be performed after standard cytotoxic chemotherapy as significant molecular changes are rarely
observed. Changes in the molecular profile can more commonly be seen after targeted therapies and repeat testing may be considered to
guide future targeted therapy decisions.
KRAS, NRAS, and BRAF Mutation Testing
• All patients with metastatic CRC should have tumor genotyped for RAS (KRAS and NRAS) and BRAF mutations individually or as part
of a next-generation sequencing (NGS) panel (preferred). Patients with any known KRAS mutation (exons 2, 3, and 4) or NRAS mutation
(exons 2, 3, and 4) should not be treated with either cetuximab or panitumumab, unless given as part of a regimen targeting a KRAS G12C
mutation.59-61 BRAF V600E mutation makes response to panitumumab or cetuximab highly unlikely.62-64
• BRAF V600E mutation testing via IHC is also an option.
• Testing for KRAS, NRAS, and BRAF mutations should be performed only in laboratories that are certified under the Clinical Laboratory
Improvement Amendments of 1988 (CLIA-88) as qualified to perform high-complexity clinical laboratory (molecular pathology) testing. No
specific methodology is recommended (eg, sequencing, hybridization).
• The testing can be performed on the primary CRCs and/or the metastasis, as literature has shown that the KRAS, NRAS, and BRAF
mutations are similar in both specimen types.65

Microsatellite Instability or Mismatch Repair Testing

• Universal MMRa or MSIa testing is recommended in all newly diagnosed patients with rectal cancer. See NCCN Guidelines for Genetic/
Familial High-Risk Assessment: Colorectal.
• The presence of a BRAF V600E mutation in the setting of MLH1 absence would preclude the diagnosis of Lynch syndrome (LS) in the vast
majority of patients. However, approximately 1% of cancers with BRAF V600E mutations (and loss of MLH1) are LS. Caution should be
exercised in excluding patients with a strong family history from germline screening in the case of BRAF V600E mutations.66
• MMR or MSI testing should be performed only in CLIA-approved laboratories.
• Testing for MSI may be accomplished by polymerase chain reaction (PCR) or a validated NGS panel, the latter especially in patients with
metastatic disease who require genotyping of RAS and BRAF.
• IHC refers to staining tumor tissue for protein expression of the four MMR genes known to be mutated in LS (MLH1, MSH2, MSH6, and
PMS2). A normal IHC test implies that all four MMR proteins are normally expressed (retained). Loss (absence) of expression of one or more
of the four DNA MMR proteins is often reported as abnormal or positive IHC. When IHC is reported as positive, caution should be taken to
ensure that positive refers to absence of mismatch expression and not presence of expression. NOTE: Normal is the presence of positive
protein staining (retained/intact) and abnormal is negative or loss of staining of protein. Loss of protein expression by IHC in any one of the
MMR genes guides further genetic testing (mutation detection to the genes where the protein expression is not observed). Abnormal MLH1
IHC should be followed by tumor testing for BRAF V600E mutation or MLH1 promoter methylation. The presence of BRAF V600E mutation or
MLH1 promoter methylation is consistent with sporadic cancer. However, caution should be exercised in excluding patients from germline
screening based on BRAF V600E mutations in the setting of a strong family history.66
HER2 Testing and NTRK Fusions on REC-B (6 of 11)
a IHC for MMR and DNA analysis for MSI are different assays and measure different biological effects caused by deficient MMR function. References

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HER2 Testing
• Diagnostic testing is via IHC, fluorescence in situ hybridization (FISH), or NGS.
• Positive by IHC is defined as: 3+ staining in more than 50% of tumor cells. 3+ staining is defined as an intense membrane staining that can
be circumferential, basolateral, or lateral. Those that have a HER2 score of 2+ should be reflexed to FISH testing.67-69 HER2 amplification by
FISH is considered positive when the HER2:CEP17 ratio is ≥2 in more than 50% of the cells.67-69 NGS is another methodology for testing for
HER2 amplification.70
• Anti-HER2 therapy with signal transduction inhibition (eg, trastuzumab/pertuzumab, trastuzumab/tucatinib, trastuzumab/lapatinib) is only
indicated in HER2-amplified tumors that are also RAS and BRAF wild-type.
• Fam-trastuzumab deruxtecan-nxki is only indicated in HER2-amplified tumors (IHC 3+).

NTRK Fusions
• NTRK fusions are extremely rare in CRCs.71 The overall incidence is approximately 0.35% in a cohort of 2314 CRCs, with NTRK fusions
confined to those tumors that are pan–wild-type KRAS, NRAS, and BRAF. In one study of eight CRCs harboring NTRK fusions, seven were
found in the small subset that were dMMR (MLH-1)/MSI-H.72 NTRK fusions are more frequently found among patients with dMMR.
• NTRK inhibitors have been shown to have activity ONLY in those cases with NTRK fusions, and NOT with NTRK point mutations.
• Methodologies for detecting NTRK fusions are IHC,73 FISH, DNA-based NGS, and RNA-based NGS.72,74 In one study, DNA-based sequencing
showed an overall sensitivity and specificity of 81.1% and 99.9%, respectively, for detection of NTRK fusions when compared to RNA-based
sequencing and IHC showed an overall sensitivity of 87.9% and specificity of 81.1%. Since approximately one in five tumors identified
as having an NTRK fusion by IHC will be a false positive, tumors that test positive by IHC should be confirmed by RNA NGS. That same
study commented that RNA-based sequencing appears to be the optimal way to approach NTRK fusions, because the splicing out of
introns simplifies the technical requirements of adequate coverage and because detection of RNA-level fusions provides direct evidence of
functional transcription.74 However, selection of the appropriate assay for NTRK fusion detection depends on tumor type and genes.

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References

Note: All recommendations are category 2A unless otherwise indicated.

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POLE/POLD1
• Polymerase genes, POLE and POLD1, encode proteins tasked with proofreading functions to recognize and correct mispaired bases
incorporated during DNA replication. Pathogenic variants (PVs) within the exonuclease domains (ED) of POLE and POLD1 result in loss of
this proofreading function leading to subsequent acquisition of numerous single nucleotide variants (SNVs).75,76
• Germline PVs within the ED of POLE and POLD1 predispose patients to multiple colorectal adenomas and carcinomas, resulting in
polymerase proofreading-associated polyposis (PPAP)75,76 (see NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal).
• Somatic POLE PVs occur in approximately 2%–8% of patients with predominately MSS/pMMR CRC while somatic POLD1 PVs are extremely
rare.75,77
• NGS of CRCs arising in patients with either germline or somatic ED PVs demonstrate an ultramutator phenotype identified as extremely
high tumor mutational burden (TMB >100 mut/Mb). TMB is calculated as the total number of somatic mutations per coding area of the tumor
genome. Although calculations vary according to assay performed, TMB >10 mut/Mb is generally regarded as TMB-high (TMB-H).77,78
• POLE/POLD1 PVs can be identified through single gene assays (PCR or Sanger sequencing). However, TMB calculation requires a larger
NGS panel, which often includes concurrent POLE/POLD1 sequencing. As such, performing a large NGS assay on CRC tumor tissue has
the advantage of not only identifying POLE/POLD1 PVs but also provides direct evidence of loss of proofreading function (TMB-H).77-79
• Patients with CRC harboring POLE/POLD1 PVs have a more favorable prognosis, likely secondary to immune responses stimulated by the
presence of numerous neoantigens produced as a consequence of aberrant proofreading function. Similarly, for these patients disease
responds well to immune checkpoint inhibitor therapy.79-84

RET Fusions
• RET is a receptor tyrosine kinase that plays a critical role in the development and maintenance of neural and genitourinary tissues,
primarily through downstream MAPK and PI3K signaling pathways.85
• Germline activating mutations in RET lead to multiple endocrine neoplasia type 2 (MEN2) (see NCCN Guidelines for Neuroendocrine and
Adrenal Tumors) and loss of function mutations are associated with Hirschsprung disease and congenital abnormalities of the kidney and
urinary tract.85
• Somatic activating alterations in RET include point mutations as well as gene rearrangements and have been identified in a variety of
tumors.85,86
• In patients with CRC, activating RET fusions involving the C-terminal kinase domain lead to constitutive upregulation of RET kinase activity
and subsequent promotion of cell proliferation and survival. The most common gene fusion partners reported include KIF5B, CCDC6, and
NCOA4.85-88
• The RET-targeted inhibitor, selpercatinib, is FDA-approved for patients with solid tumors harboring activating RET fusions.89
• The presence of RET fusions can be interrogated through a variety of techniques, including IHC, FISH, PCR, and either DNA- or RNA-based
NGS assays. RNA-based NGS assays are fusion agnostic and as such have the advantage of identifying RET fusions involving any partner
gene.86-88

References

Note: All recommendations are category 2A unless otherwise indicated.

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PRINCIPLES OF PATHOLOGIC AND MOLECULAR REVIEW – REFERENCES

1 Volk EE, Goldblum JR, Petras RE, et al. Management and outcome of 14 Wibe A, Rendedal PR, Svensson E, et al. Prognostic significance of the
patients with invasive carcinoma arising in colorectal polyps. Gastroenterology circumferential resection margin following total mesorectal excision for rectal
1995;109:1801-1807. cancer. Br J Surgery 2002;89 327-334.
2 Cooper HS, Deppisch LM, Gourley WK, et al. Endoscopically removed 15 Washington MK, Berlin J, Branton P, et al. Protocol for examination of
malignant colorectal polyps: clinical pathological correlations. Gastroenterology specimens from patients with primary carcinoma of the colon and rectum. Arch
1995;108:1657-1665. Pathol Lab Med 2009;133:1539.
3 Ueno H, Mochizuki H, Hashiguchi Y, et al. Risk factors for an adverse outcome in 16 Edge SB, Byrd D, Compton C, et al (eds). AJCC Cancer Staging Manual, 7th
early invasive colorectal carcinoma. Gastroenterology 2004;127:385-394. ed. New York: Springer; 2010.
4 Seitz U, Bohnacker S, Seewald S, et al. Is endoscopic polypectomy an adequate 17 Nagtegaal ID, Quirke P. What is the role for the circumferential margin in the
therapy for malignant colorectal polyps? Presentation of 114 patients and review modern treatment of rectal cancer? J Clin Oncol 2008;26:303-312.
of the literature. Dis Colon Rectum 2004;47:1789-1797. 18 Rodel C, Martus P, Papadoupolos T, et al. Prognostic significance of tumor
5 Morson BC, Whiteway JE, Jones EA, et al. Histopathology and prognosis regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol
of malignant colorectal polyps treated by endoscopic polypectomy. Gut 2005;23:8688-8696.
1984;25:437-444. 19 Ryan R, Gibbons D, Hyland JMP, et al. Pathological response following
6 Haggitt RC, Glotzbach RE, Soffer EE, Wruble LD. Prognostic factors in colorectal long-course adjuvant chemoradiotherapy for locally advanced rectal cancer.
carcinomas arising in adenomas: implications for lesions removed by endoscopic Histopathology 2005;47:141-146.
polypectomy. Gastroenterology 1985;89:328-336. 20 Gavioli M, Luppi G, Losi L, et al. Incidence and clinical impact of sterilized
7 Netzer P, Binck J, Hammer B, et al. Significance of histological criteria for the disease and minimal residual disease after preoperative radiochemotherapy for
management of patients with malignant colorectal polyps. Scand J Gastroenterol rectal cancer. Dis Colon Rectum 2005;48:1851-1857.
1997;323:915-916. 21 Nissan A, Stojadinovic A, Shia J, et al. Predictors of recurrence in patients with
8 Hager T, Gall FP, and Hermanek P. Local excision of cancer of the rectum. Dis T2 and early T3, N0 adenocarcinoma of the rectum treated by surgery alone. J
Colon Rect 1983;26:149-151. Clin Oncol 2006;24:4078-4084.
9 Willett, CG, Tepper JE, Donnelly S, et al. Patterns of failure following local 22 Liebig C, Ayala G, Wilks J, et al. Perineural invasion is an independent predictor
excision and local excision and postoperative radiation therapy for invasive rectal of outcome in colorectal cancer. J Clin Oncol 2009;27:5131-5137.
adenocarcinoma. J Clin Oncol 1989;7:1003-1008. 23 Fujita S, Shimoda T, Yoshimura K, et al. Prospective evaluation of prognostic
10 Nascimbeni R, Burgart LJ, Nivatvongs S, and Larson DR. Risk of lymph factors in patients with colorectal cancer undergoing curative resection. J Surg
node metastasis in T1 carcinoma of the colon and rectum. Dis Colon Rectum Oncol 2003;84:127-131.
2002;45:2001-2006. 24 Quah HM. Identification of patients with high risk stage II colon cancer for
11 Compton CC and Greene FL. The staging of colorectal cancer: 204 and beyond. adjuvant therapy. Dis Colon Rect 2008;51:503-507.
Cancer J Clin 2004;54:295-308. 25 Ueno H, Mochizuki H, Hashiguchi Y, et al. Extramural cancer deposits without
12 Compton CC, Fielding LP, Burkhardt LJ, et al. Prognostic factors in colorectal nodal structure in colorectal cancer: optimal categorization for prognostic
cancer. College of American pathologists consensus statement. Arch Pathol Lab staging. J Clin Pathol 2007;117:287-294.
Med 2000;124:979-994. 26 Lo DS, Pollett A, Siu LL, et al. Prognostic significance of mesenteric tumor
13 Nagtegaal ID, Merijnenca M, Kranenbarg EK, et al. Circumferential margin nodules in patients with stage III colorectal cancer. Cancer 2008;112:50-54.
involvement is still an important predictive local occurrence in rectal 27 Lugli A, Kirsch R, Ajioka Y, et al. Recommendations for reporting tumor budding
carcinoma. Not one millimeter but two millimeters is the limit. Am J Surg Pathol in colorectal cancer based on the International Tumor Budding Consensus
2002;26:350-357. Conference (ITBCC) 2016. Mod Pathol 2017;30:1299-1311.
28 Lee VWK, Chan KF. Tumor budding and poorly-differentiated cluster in
prognostication in Stage II colon cancer. Pathol Res Pract 2018;214:402-407.
Continued
Note: All recommendations are category 2A unless otherwise indicated.
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Rectal Cancer Discussion

PRINCIPLES OF PATHOLOGIC AND MOLECULAR REVIEW – REFERENCES

29 Romiti A, Roberto M, Marchetti P, et al. Study of histopathologic parameters to 43 Tepper JE, O’Connell MJ, Niedzwiecki D, et al. Impact of number of nodes
define the prognosis of stage II colon cancer. Int J Colorectal Dis 2019;34:905- retrieved on outcome in patients with rectal cancer. J Clin Oncol 2001;19:157-
913. 162.
30 Costas-Chavarri A, Nandakumar G, Temin S, et al. Treatment of patients with 44 Scott KWM and Grace RH. Detection of lymph node metastasis and colorectal
early-stage colorectal cancer: ASCO Resource-Stratified Guideline. J Glob carcinoma before and after fat clearance. Br J Surg 1989;76:1165-1167.
Oncol 2019;5:1-19. 45 Wichmann MW, Mollar C, Meyer G, et al. Effect of pre-operative
31 Koelzer VH, Zlobec I, Lugli A. Tumor budding in colorectal cancer – ready for radiochemotherapy on lymph node retrieval after resection of rectal cancer. Arch
diagnostic practice? Hum Pathol 2016;47:4-19. Surg 2002;137:206-210.
32 Bosch SL, Teerenstra S, de Wilt JH, et al. Predicting lymph node metastasis in 46 Baxter NN, Morris AM, Rothenberger DA, and Tepper JE. Impact of pre-
pT1 colorectal cancer: a systematic review of risk factors providing rationale for operative radiation for rectal cancer on subsequent lymph node evaluation:
therapy decisions. Endoscopy 2013;45:827-834. population based analysis. Int J Radiation Oncology Biol Phys 2005;61:426-431.
33 Brown IS, Bettington ML, Bettington A, et al. Adverse histological features in 47 Amin MB, Edge SB, Greene F, et al. (eds.) AJCC Cancer Staging Manual, 8th
malignant colorectal polyps: a contemporary series of 239 cases. J Clin Pathol ed. New York: Springer; 2017.
2016;69:292-299. 48 Turner RR, Nora DT, Trochas D, and Bilchik AJ. Colorectal carcinoma in nodal
34 Backes Y, Elias SG, Groen JN, et al. Histologic factors associated with staging. Frequency and nature of cytokeratin positive cells in sentinel and
need for surgery in patients with pedunculated T1 colorectal carcinomas. nonsentinel lymph nodes. Arch Pathol Lab Med 2003;127:673-679.
Gastroenterology 2018;154:1647-1659. 49 Wood TF, Nora DT, Morton DL, et al. One hundred consecutive cases of
35 Pai RK, Chen YW, Jakubowski MA, et al. Colorectal carcinomas with sentinel node mapping in early colorectal carcinoma. Detection of missed
submucosal invasion (pT1): analysis of histopathological and molecular factors micrometastasis. J Gastroinest Surg 2002;6:322-330.
predicting lymph node metastasis. Mod Pathol 2017;30:113-122. 50 Wiese DA, Sha S, Badin J, et al. Pathological evaluation of sentinel lymph
36 Sobin HL and Green EFL. TNM classification. Clarification of number of regional nodes in colorectal carcinoma. Arch Pathol Lab Med 2000;124:1759-1763.
lymph nodes for PN0. Cancer 2001;92:452. 51 Noura S, Yamamoto H, Ohnishi T, et al. Comparative detection of lymph
37 Sarli L, Bader G, Lusco D, et al. Number of lymph nodes examined and node micrometastasis of stage II colorectal cancer by reverse transcriptase
prognosis of TNM stage II colorectal cancer. Eur J Cancer 2005;41:272-279. polymerase chain reaction in immunohistochemistry. J Clin Oncol 2002;20:4232-
38 Chaplin S, Scerottini G-P, Bosman FT, et al. For patients with Duke’s B (TNM 4241.
stage II) colorectal carcinoma, examination of six or fewer lymph nodes is 52 Yasuda K, Adachi Y, Shiraishi N, et al. Pattern of lymph node micrometastasis
related to poor prognosis. Cancer 1998;83:666-672. and prognosis of patients with colorectal cancer. Ann Surg Oncol 2001;8:300-
39 Maurel J, Launoy G, Grosclaude P, et al. Lymph node harvest reporting in 304.
patients with carcinoma of the large bowel. A French population-based study. 53 Noura S, Yamamoto H, Miyake Y, et al. Immunohistochemical assessment of
Cancer 1998;82:1482-1486. localization of frequency of micrometastasis in lymph nodes of colorectal cancer.
40 Pocard M, Panis Y, Malassagane B, et al. Assessing the effectiveness of Clin Cancer Research 2002;8:759-767.
mesorectal excision in rectal cancer. Dis Colon Rectum 1998;41:839-845. 54 Oberg A, Stenling R, Tavelin B, Lindmark G. Are lymph node micrometastasis
41 Joseph NE, Sigurdson ER, Hamlin AL, et al. Accuracy of determining nodal of any clinical significance in Duke stages A and B colorectal cancer? Dis Colon
negativity in colorectal cancer on the basis of number of nodes retrieved on Rectum 1998;41:1244-1249.
resection. Ann of Surg Oncol 2003;10:213-218. 55 Greenson JK, Isenhart TCE, Rice R, et al. Identification of occult
42 Goldstein NS. Lymph node recurrences from 2427 PT3 colorectal resection micrometastasis in pericolonic lymph nodes of Duke’s B colorectal cancer.
specimens spanning 45 years. Recommendations for a minimum number of Patient’s using monoclonal antibodies against cytokeratin and CC49. Correlation
recovered lymph nodes based on predictive probabilities. Am J Surg Pathol with long term survival. Cancer 1994;73:563-569.
2002;26:179-189.
Continued

Note: All recommendations are category 2A unless otherwise indicated.

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PRINCIPLES OF PATHOLOGIC AND MOLECULAR REVIEW – REFERENCES

56 Parfitt 68 Evaluation of Trastuzumab in Combination With Lapatinib or Pertuzumab in
JR and Driman KR. Total mesorectal excision specimen for rectal cancer:
A review of its pathological assessment. J Clin Pathol 2007;60:849-855. Combination With Trastuzumab-Emtansine to Treat Patients With HER2-positive
57 Jass JR, O’Brien MJ, Riddell RH, Snover DC. On behalf of the association Metastatic Colorectal Cancer (HERACLES). https://clinicaltrials.gov/ct2/show/
of Directors of Anatomic and Surgical Pathology recommendations for the NCT03225937
69 Sartore-Bianchi A, Trusolino L, Martino C, et al. Dual-targeted therapy with
reporting of surgically resected specimens in colorectal carcinoma. Human
Pathol 2007;38:537-545. trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type,
58 Nagtegaal ID, van de Velde CJH, van der Derworp E, et al. Macroscopic HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept,
evaluation of the rectal cancer resection specimen: Clinical significance of the multicentre, open-label, phase 2 trial. Lancet Oncol 2016;17:738-746.
70 Cenaj O, Ligon AH, Hornick JL, et al. Detection of ERBB2 amplification by next-
pathologist in quality control. J Clin Oncol 2002;20:1729-1734.
59 Lievre A, Bachatte J-B, Blige V, et al. KRAS mutations as an independent generation sequencing predicts HER2 expression in colorectal carcinoma. Am J
prognostic factor in patients with advanced colorectal cancer treated with Clin Pathol 2019;152:97-108.
71 Solomon JP, Hechtman JF. Detection of NTRK fusions: Merits and limitations of
Cetuximab. J Clin Oncol 2008;26:374-379.
60 Amado IG, Wolf M, Peters M, et al. Wild-type KRAS is required for current diagnostic platforms. Cancer Res 2019;79:3163-3168.
72 Cocco E, Benhamida J, Middha S, et al. Colorectal carcinomas containing
panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol
2008;26:1626-1634. hypermethylated MLH1 promotor and wild-type BRAF/KRAS are enriched for
61 Douillard JY, Oliner KS, Siena S, et al. Panitumumab--FOLFOX4 treatment and targetable kinase fusions. Cancer Res 2019;79:1047-1053.
73 Hechtman JF, Benayed R, Hyman DM, et al. Pan-Trk Immunohistochemistry is
RAS mutations in colorectal cancer. N Engl J Med 2013;369:1023-1034.
62 Di Nicolantonio F, Martini M, Molinari F, et al. Wild-type BRAF is required for an efficient and reliable screen for the detection of NTRK fusions. Am J Surg
response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Pathol 2017;41:1547-1551.
74 Solomon JP, Linkov I, Rosado A, et al. NTRK fusion detection across multiple
Oncol 2008;26:5705-5712.
63 Bokmeyer C, Cutsem EV, Rougier P, et al. Addition of cetuximab to assays and 33,997 cases: diagnostic implications and pitfalls. Mod Pathol
chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal 2020;33:38-46.
75 Mur P, García-Mulero S, Del Valle J, et al. Role of POLE and POLD1 in familial
cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials.
Eur J Cancer 2012;48:1466-1475. cancer. Genet Med 2020;22:2089-2100.
64 Pietrantonio F, Petrelli F, Coinu A, et al. Predictive role of BRAF mutations 76 Mur P, Viana‑Errasti J, Garcia‑Mulero S, et al. Recommendations for the
in patients with advanced colorectal cancer receiving cetuximab and classification of germline variants in the exonuclease domain of POLE and
panitumumab: a meta-analysis. Eur J Cancer 2015;51:587-594. POLD1. Genome Med 2023;15:85.
65 Etienne-Gimeldi M-C, Formenta J-L, Francoual M, et al. KRAS mutations 77 Forgó E, Gomez AJ, Steiner D, et al. Morphological, immunophenotypical and
in treatment outcome in colorectal cancer in patients receiving exclusive molecular features of hypermutation in colorectal carcinomas with mutations in
fluoropyrimidine. Clin Cancer Research 2008;14:4830-4835. DNA polymerase ε (POLE) Histopathology 2020;76:366-374.
66 Parsms MT, Buchanan DD, Thompson B, et al. Correlation of tumor BRAF 78 Fenizia F, Wolstenholme N, Fairley JA, et al. Tumor mutation burden testing: a
mutations and MLH-1 methylation with germline mismatch repair (MMR) gene survey of the International Quality Network for Pathology (IQN Path). Virchows
mutation status: a literature review accessions utility of tumor features for MMR Arch 2021;479:1067-1072.
79 Domingo E, Freeman-Mills L, Rayner E, et al. Somatic POLE proofreading
variant classification. J Med Genet 2012;49:151-157.
67 Valtorta E, Martino C, Sartore-Bianchi A, et al. Assessment of a HER2 scoring domain mutation, immune response, and prognosis in colorectal cancer: a
system for colorectal cancer: results from a validation study. Mod Pathol retrospective, pooled biomarker study. Lancet Gastroenterol Hepatol 2016;1:207-
2015;28:1481-1491. 216.

Continued
Note: All recommendations are category 2A unless otherwise indicated.
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PRINCIPLES OF PATHOLOGIC AND MOLECULAR REVIEW – REFERENCES

80 Bourdais R, Rousseau B, Pujals A, et al. Polymerase proofreading domain mutations: New opportunities for immunotherapy in hypermutated colorectal cancer
beyond MMR deficiency. Crit Rev Oncol Hematol 2017;113:242-248.
81 Garmezy B, Gheeya J, Lin HY, et al. Clinical and molecular characterization of POLE mutations as predictive biomarkers of response to immune checkpoint inhibitors
in advanced cancers. JCO Precis Oncol 2022;6:e2100267.
82 Kelly RJ, Bever K, Chao J, et al. Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gastrointestinal
cancer. J Immunother Cancer 2023;11:e006658.
83 Mo S, Ma X, Li Y, et al. Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer. J Immunother
Cancer 2020;8:e000881.
84 Castellucci E, He T, Yitzchak Goldstein D, et al. DNA polymerase ɛ deficiency leading to an ultramutator phenotype: A novel clinically relevant entity. Oncologist
2017;22:497-502.
85 Lois M Mulligan. RET revisited: expanding the oncogenic portfolio. Nat Rev Cancer 2014;14:173-186.
86 Le Rolle AF, Klempner SJ, Garrett CR, et al. Identification and characterization of RET fusions in advanced colorectal cancer. Oncotarget 2015;6:28929-28937.
87 Heydt C, Wölwer CB, Velazquez Camacho O, et al. Detection of gene fusions using targeted next-generation sequencing: a comparative evaluation. BMC Med
Genomics 2021;14:62.
88 Pietrantonio F, Di Nicolantonio F, Schrock AB, et al. RET fusions in a small subset of advanced colorectal cancers at risk of being neglected. Ann Oncol
2018;29:1394-1401.
89 Subbiah V, Wolf J, Konda B, et al. Tumour-agnostic efficacy and safety of selpercatinib in patients with RET fusion-positive solid tumours other than lung or thyroid
tumours (LIBRETTO-001): a phase 1/2, open-label, basket trial. Lancet Oncol 2022;23:1261-1273.

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PRINCIPLES OF SURGERY AND LOCOREGIONAL THERAPIES

Workup Anticipated circumferential margins should be assessed by MRI (see
• Independent evaluation by the treating surgeon with either proctosigmoidoscopy
or flexible sigmoidoscopy is recommended for all rectal tumors. Critical Principles of Imaging, REC-A) prior to any required neoadjuvant therapy, and
characteristics to be documented, in conjunction with digital rectal examination again considered prior to surgery. If margins are involved, assessment for
(DRE), include tumor size, distances from the anal verge and the anorectal ring, feasibility of resection beyond the TME plane is required. Such an extended
orientation within the rectal lumen (eg, anterior-posterior, laterality) and/or degree resection (± reconstruction) should involve careful preoperative planning and
of circumferential involvement, extent of obstruction, extent of fixation to the rectal may require a multidisciplinary team.
wall, degree of sphincter involvement, and sphincter tone. For adequately staged, low-risk, upper-rectal T3, N0 tumors, surgery alone is
Transanal Local Excision1 an appropriate treatment option.
• Criteria Remove primary tumor with adequate circumferential and distal margins.
<30% circumference of bowel; <3 cm in size; clear surgical margin (>3 mm); Treat draining lymphatics by TME.
mobile, nonfixed; within 8 cm of anal verge; T1 only; endoscopically removed Sphincter preservation and restoration of organ integrity should be achieved
polyp with cancer or indeterminate pathology; no lymphovascular invasion without compromise of oncologic resection and consideration of anticipated
or PNI; well to moderately differentiated; no evidence of lymphadenopathy on patient functional outcome and quality of life.
pretreatment imaging • TME is a standard component of radical rectal cancer surgery. TME reduces
Surgical technique includes full thickness excision of rectal wall with goal of the positive radial margin and local recurrence rates.
≥10mm excision margin with an intact non-fragmented specimen. Extend 4 to 5 cm below distal edge of tumors for an adequate mesorectal
• When the lesion can be adequately localized to the rectum, local excision of more excision. In distal rectal cancers (ie, <5 cm from anal verge), negative distal
proximal lesions may be technically feasible using advanced techniques, such as bowel wall margin of 1 to 2 cm may be acceptable.
transanal endoscopic microsurgery (TEM) or transanal minimally invasive surgery Full rectal mobilization allows for a negative distal margin and adequate
(TAMIS). mesorectal excision.
• Local excision could be a viable option for patients who have a strong but Some studies have shown that minimally-invasive approaches (e.g.
incomplete response and are unable or unwilling to undergo standard TME
surgery. The most suitable candidates would be those meeting the near complete laparoscopic, robotic) are associated with similar short- and long-term
response (nCR) criteria as outlined in the Principles of Nonoperative Management outcomes when compared to open surgery,3,4 whereas other studies have
section (endoscopy, DRE, and MRI). shown that laparoscopy is associated with higher rates of circumferential
• The efficacy of local excision for patients who have achieved a clinical complete margin positivity and incomplete TME.5,6 Therefore, minimally invasive
response (cCR) is not yet fully established. According to current data, cCR, as resection may be considered based on the following principles:
determined through MRI, DRE, and endoscopy, typically correlates with a durable ◊ The surgeon should have experience performing minimally invasive
response. Therefore, implementing local excision might introduce unnecessary proctectomy with TME.
risks without clear benefits. Given this uncertainty and potential for added risk, ◊ It is not indicated for locally advanced disease with a threatened or high-
local excision is not routinely recommended for patients who have achieved a risk circumferential margin based on staging. For these high-risk tumors,
clear cCR. open surgery is preferred.
Transabdominal Resection: Abdominoperineal resection or low anterior resection or ◊ It is not generally indicated for acute bowel obstruction or perforation from
coloanal anastomosis using TME cancer.
• Management principles ◊ Thorough abdominal exploration is required.
The treating surgeon should be experienced in rectal cancer surgery, and • Lymph node dissection7,8
specifically with TME. For patients with predicted positive margins based on Clinically suspicious nodes beyond the field of resection should be biopsied
preoperative imaging, or lateral pelvic lymph node involvement, the surgeon and/or removed, if possible. Extensive resection of M1 lymph nodes is not
should be experienced in extended resections beyond the TME plane and have a indicated.
multidisciplinary team available if necessary.2 Extended lymph node resection is not indicated in the absence of clinically
The treating surgeon should assess the distal margin before initiating treatment suspected nodes.
by DRE ± rigid or flexible endoscopy, particularly for non-palpable lesions.
Continued
References
Note: All recommendations are category 2A unless otherwise indicated.
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Locoregional Therapies
• Image Guided Tumor Ablation9
Thermal ablation creates tumor cell death through deposition of tumoricidal heat (radiofrequency or microwave) or cold (cryoablation) in
the tumor and surrounding margins.
Non-thermal ablation such as irreversible electroporation creates tumor cell death through electrical pulses that create irreversible
membrane pores and cellular lysis/destruction.

• Liver Tumor Ablation9-11

Thermal ablation can be considered alone, or in conjunction with surgery, in appropriately selected patients with small metastases that can
be treated with margins. All original sites of disease need to be amenable to thermal ablation or resection.
Image guided thermal ablation may be considered in selected surgical candidates or medically non-surgical candidates with small tumors
that can be completely ablated with margins.
Image guided thermal ablation can be considered in selected patients with recurrence after hepatectomy or ablation as long as all visible
disease can be ablated with margins.9-11
Image guided non-thermal ablation (irreversible electroporation) can be considered in patients that cannot be safely resected or ablated
with margins due to proximity to central bile ducts or other structures that cannot be protected.

• Lung Tumor Ablation12-14

Ablative techniques may be considered alone or in conjunction with resection for resectable disease. All original sites of disease need to
be amenable to thermal ablation or resection.
Image guided thermal ablation can also be considered when unresectable and amenable to complete thermal ablation.
Image guided thermal ablation may be considered in selected surgical candidates with small tumors that can be completely ablated with
margins.
Image guided thermal ablation may be considered for recurrences after surgery or prior ablation as long as all visible disease is amenable
to thermal ablation.

Continued
References
Note: All recommendations are category 2A unless otherwise indicated.
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PRINCIPLES OF SURGERY AND LOCOREGIONAL THERAPIES

• Arterially Directed Embolic Therapy
Hepatic Transarterial Radioembolization (TARE) with Yttrium-90 (Y-90) Microspheres15,16
◊ Y-90 radioembolization (radiation lobectomy approach) can be considered instead of portal vein embolization when hepatic metastatic disease is
not optimally resectable based on insufficient remnant liver volume or when there is borderline resectable disease that would benefit from tumor
downsizing and remnant hypertrophy.
◊ Hepatic TARE with Y-90 microspheres can be considered in selected patients with chemotherapy-resistant/refractory disease and with
predominant hepatic metastases.
◊ Radiation segmentectomy approach can be used for limited volume liver disease that is not amenable to resection or thermal ablation.
Transarterial Chemoembolization (TACE)17
◊ TACE involves hepatic artery catheterization to locally deliver chemotherapy in combination with arterial embolization.
◊ TACE for hepatic metastatic tumors can be considered in highly selected cases with chemotherapy-resistant/refractory disease, preserved liver
function, and with predominant hepatic metastases.
◊ The most commonly accepted variation for the treatment of metastatic colorectal cancer involves the use of drug eluted bead TACE (DEB-TACE)
using irinotecan as the chemotherapeutic agent (DEBIRI).
◊ DEBIRI can be used along with irinotecan-based chemotherapy for unresectable liver dominant disease.

• External Beam Radiation Therapy (EBRT)

EBRT to the metastatic site can be considered in appropriately selected cases in which the patient has a limited number of metastases, including
the liver or lung or other select locations; or the patient is symptomatic; or in the setting of a clinical trial.
The possible techniques include three-dimensional conformal RT (3D-CRT), IMRT, and SBRT.
◊ SBRT is an advanced technique of hypofractionated RT with photons that delivers large ablative doses of radiation. SBRT in the
management of liver or lung metastases can be an alternative to ablation/embolization techniques or when these therapies have failed or are
contraindicated.18-23
◊ Consider SBRT for patients with oligometastatic disease. (see REC-E)

• Hepatic Arterial Infusion (HAI)

Eligibility:
◊ Multidisciplinary experience with HAI therapy
◊ Candidate for major surgery
◊ Unresectable colorectal liver metastases or resectable colorectal liver metastases at high risk for recurrence
◊ Treated with at least one line of systemic chemotherapy
◊ No extrahepatic disease; primary tumor may be in place
◊ Suitable hepatic arterial anatomy
◊ No portal hypertension
◊ No active viral hepatitis
◊ Direct Bilirubin <1.5 mg/dL, Alkaline Phos <2X ULN.
◊ HAI chemotherapy cannot be delivered with concurrent bevacizumab
◊ Prior radiation to the liver
Continued
References
Note: All recommendations are category 2A unless otherwise indicated.
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PRINCIPLES OF SURGERY AND LOCOREGIONAL THERAPIES

CRITERIA FOR RESECTABILITY OF METASTASES AND LOCOREGIONAL THERAPIES WITHIN SURGERY
Liver Lung
• Hepatic resection is the treatment of choice for resectable liver • Complete resection based on the anatomic location and extent of
metastases from CRC.24 disease with maintenance of adequate function is required.32-35
• Complete resection must be feasible based on anatomic grounds • The primary tumor must have been resected for cure (R0).
and the extent of disease; maintenance of adequate hepatic • Resectable extrapulmonary metastases do not preclude
function is required.25,26 resection.36-39
• There should be no unresectable extrahepatic sites of disease.27-29 • Re-resection and re-ablation can be considered in selected
• Partial debulking (R1/R2 resection) is not recommended. patients.40
• Patients with resectable metastatic disease and primary tumor in • Ablative techniques may be considered alone or in conjunction with
place should have both sites resected with curative intent. resection for resectable disease. All original sites of disease need to
These can be resected in one operation or as a staged approach, be amenable to thermal ablation or resection.
depending on the complexity of the hepatectomy or colectomy, • Ablative techniques can also be considered when unresectable and
comorbid diseases, surgical exposure, and surgeon expertise. amenable to complete thermal ablation.
Staged procedures can be performed as liver-first or primary-first • Thermal ablation may be considered in selected surgical candidates
approaches.30 with small tumors that can be completely ablated with margins.
• In the setting of neoadjuvant therapy, placement of pre-treatment • Patients with resectable synchronous metastases can be resected
fiducial marker(s) in smaller lesions may be considered. synchronously or using a staged approach.
• Re-resection and re-ablation can be considered in selected • Ablative EBRT may be considered in selected cases or in the setting
patients.31 of a clinical trial and should not be used indiscriminately in patients
• When hepatic metastatic disease is not optimally resectable who are potentially surgically resectable or can be percutaneously
based on insufficient remnant liver volume, approaches using ablated.
preoperative portal vein embolization or staged liver resections can
be considered. Evaluation for Conversion to Resectable or Ablatable Disease
• At the time of surgery, ablative techniques may be considered alone • Re-evaluation for resection and/or ablation should be considered
or in conjunction with resection.24 All original sites of disease in otherwise unresectable patients after 2 months of preoperative
should be amenable to thermal ablation or resection. chemotherapy and every 2 months thereafter.41-44
• Thermal ablation may be considered in selected surgical candidates • Metastatic tumor(s) with a higher likelihood of being converted to
with small tumors that can be completely ablated with margins. resectable and/or ablatable are those in which the initial disease is
• Arterially directed catheter therapy, and in particular yttrium-90 confined to limited sites.
microsphere radioembolization, is an option in selected patients • When considering whether disease has been converted to
with chemotherapy-resistant/-refractory disease and with resectable and/or ablatable, all original sites need to be amenable
predominant hepatic metastases. to treatment.45 Preoperative chemotherapy regimens with high
• Ablative external beam RT (EBRT) may be considered in selected response rates should be considered for patients with potentially
cases or in the setting of a clinical trial and should not be used convertible disease.46
indiscriminately in patients who are potentially surgically resectable
or can be percutaneously ablated with margins.
Continued
References
Note: All recommendations are category 2A unless otherwise indicated.
REC-C
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ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD)
Therapeutic Principles Curative Resection
• ESD is a minimally invasive, organ-preserving procedure that can • Based on both the Japanese51 and European47 guidelines, resection
provide curative resection for early rectal cancers by removing of rectal lesions can be considered curative when:
these lesions en bloc. Negative circumferential and deep vertical tumor margins
• ESD usually involves using an injection with submucosal dissection Submucosal invasion depth <1000 µm
of the lesion to achieve complete en bloc resection. Absence of lymphovascular invasion
• ESD can provide either curative resection after en bloc removal or, if Absent or grade 1 (low-grade) tumor budding
not curative, can provide an accurate pathologic staging of disease. Well (G1) to moderately (G2) differentiated tumor histology
◊ If a removed lesion does not meet the above criteria, a
Pre-ESD Endoscopic Evaluation multidisciplinary team including an endoscopist, surgeon,
• Successful curative resection of rectal lesions requires a thorough and pathologist should use a shared decision-making process
assessment of the lesion, including subclassification of laterally to decide whether to proceed with surgery vs. intensive
spreading tumor (LST), as well as vessel, surface, and pit pattern.47 surveillance.
• The morphology of all lesions should be described using the Paris
classification, which has been shown to correlate to the likelihood Surveillance After ESD49
of invasive cancer. 48 • Risk of lymph node metastasis after curative resection of superficial
• ESD should be performed at a high-volume center by an T1 rectal cancer with submucosal invasion <1000µm is estimated to
experienced endoscopist or surgeon.47 be 3%–6%.
• EUS or MRI should be used in the rectum prior to resection when • Flexible sigmoidoscopy is recommended 3–6 months after ESD
suspicious features of deep submucosal invasion are present.47 assuming prior colonoscopy.
• Second follow-up endoscopy is recommended 3–6 months after first
Criteria for Resection surveillance exam or colonoscopy if 1 year from ESD.
• ESD with en bloc resection should be considered for rectal lesions • Surveillance using flexible sigmoidoscopy is recommended every 6
at risk for submucosally invasive cancer49,50 months for a total of 5 years from ESD.
Type V Kudo pit pattern • EUS or pelvic MRI with contrast is recommended every 3–6 months
Depressed component (Paris 0–IIc) for 2 years, then every 6 months to complete 5 years.
Complex morphology (0–Is or 0–IIa+Is)
Nongranular, laterally spreading tumor >20 mm in size Surgery vs. ESD
Granular, laterally spreading tumor >30 mm in size • Prior retrospective studies have found that ESD and TEM/TAMIS
• Residual or recurrent colorectal adenomas do not differ in terms of outcomes, including local recurrence, R0
• Rectal lesions that have surface features (vascular or pit pattern) resection rate, and adverse events.52-54
suggestive of advanced dysplasia or early submucosally invasive • The decision between surgery and ESD should be determined based
carcinoma on the patient’s candidacy for surgery, availability of expertise in
ESD, and patient preference.

References

Note: All recommendations are category 2A unless otherwise indicated.

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PRINCIPLES OF SURGERY AND LOCOREGIONAL THERAPIES – REFERENCES

1 Nash GM, Weiser MR, Guillem JG, et al. Long-term survival after transanal 13 de Baere T, Aupérin A, Deschamps F, et al. Radiofrequency ablation is a valid
excision of T1 rectal cancer. Dis Colon Rectum 2009;52:577-582. treatment option for lung metastases: experience in 566 patients with 1037
2 Beyond TME Collaborative. Consensus statement on the multidisciplinary metastases. Ann Oncol 2015;26:987–991.
management of patients with recurrent and primary rectal cancer beyond total 14 Callstrom MR, Woodrum DA, Nichols FC, et al. Multicenter Study of Metastatic
mesorectal excision planes. Br J Surg 2013;100:1009-1014. Lung Tumors Targeted by Interventional Cryoablation Evaluation (SOLSTICE).
3 Fleshman J, Branda ME, Sargent DJ, et al. Disease-free survival and local J Thorac Oncol 2020;15:1200-1209.
recurrence for laparoscopic resection compared with open resection of stage II to 15 Mulcahy MF, Mahvash A, Pracht M, et al. Radioembolization With
III rectal cancer: Follow-up results of the ACOSOG Z6051 randomized controlled Chemotherapy for Colorectal Liver Metastases: A Randomized, Open-Label,
trial. Ann Surg 2019;269:589-595. International, Multicenter, Phase III Trial. J Clin Oncol 2021;39:3897-3907.
4 Jayne D, Pigazzi A, Marshall H, et al. Effect of Robotic-Assisted vs Conventional 16 Wasan HS, Gibbs P, Sharma NK, et al. First-line selective internal radiotherapy
Laparoscopic Surgery on Risk of Conversion to Open Laparotomy Among plus chemotherapy versus chemotherapy alone in patients with liver metastases
Patients Undergoing Resection for Rectal Cancer: The ROLARR Randomized from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a
Clinical Trial. JAMA 2017;318:1569-1580. combined analysis of three multicentre, randomised, phase 3 trials. Lancet
5 Fleshman J, Branda M, Sargent DJ, et al. Effect of laparoscopic-assisted Oncol 2017;18:1159-1171.
resection vs open resection of stage II or III rectal cancer on pathologic 17 Fiorentini G, Aliberti C, Tilli M, et al. Intra-arterial infusion of irinotecan-loaded
outcomes. The ACOSOG Z6051 randomized clinical trial. JAMA 2015;314:1346- drug-eluting beads (DEBIRI) versus intravenous therapy (FOLFIRI) for hepatic
1355. metastases from colorectal cancer: final results of a phase III study. Anticancer
6 Stevenson ARL, Solomon MJ, Lumley JW, et al. Effect of laparoscopic-assisted Res 2012;32:1387-95. Erratum in: Anticancer Res.2013;33:5211.
resection vs open resection on pathological outcomes in rectal cancer. The 18 Goodman BD, Mannina EM, Althouse SK, et al. Long-term safety and efficacy
ALacaRT randomized clinical trial. JAMA 2015;314:1356-1363. of stereotactic body radiation therapy for hepatic oligometastases. Pract Radiat
7 Gunderson LL, Sargent DJ, Tepper JB, et al. Impact of T and N stage and Oncol 2016;6:86-95.
treatment on survival and relapse in adjuvant rectal cancer: a pooled analysis. J 19 Joo JH, Park JH, Kim JC, et al. Local Control Outcomes Using Stereotactic
Clin Oncol 2004;22:1785-1796. Body Radiation Therapy for Liver Metastases From Colorectal Cancer. Int J
8 Greene FL, Stewart AK, Norton HJ. New tumor-node-metastasis staging Radiat Oncol Biol Phys 2017;99:876-883.
strategy for node-positive (stage III) rectal cancer: an analysis. J Clin Oncol 20 Agolli L, Bracci S, Nicosia L, et al. Lung Metastases Treated With Stereotactic
2004;22:1778-1784. Ablative Radiation Therapy in Oligometastatic Colorectal Cancer Patients:
9 Chlorogiannis DD, Sotirchos VS, Georgiades C, et al. The Importance of Optimal Outcomes and Prognostic Factors After Long-Term Follow-Up. Clin Colorectal
Thermal Ablation Margins in Colorectal Liver Metastases: A Systematic Review Cancer 2017;16:58-64.
and Meta-Analysis of 21 Studies. Cancers (Basel) 2023;15:5806. 21 Jingu K, Matsuo Y, Onishi H, et al. Dose Escalation Improves Outcome in
10 Ruers T, Van Coevorden F, Punt CJ, et al. Local Treatment of Unresectable Stereotactic Body Radiotherapy for Pulmonary Oligometastases from Colorectal
Colorectal Liver Metastases: Results of a Randomized Phase II Trial. J Natl Cancer. Anticancer Res 2017;37:2709-2713.
Cancer Inst 2017;109:djx015. 22 Nicosia L, Franceschini D, Perrone-Congedi F, et al. A multicenter LArge
11 Vasiniotis Kamarinos N, Vakiani E, Gonen M, et al. Biopsy and Margins retrospectIve daTabase on the personalization of stereotactic ABlative
Optimize Outcomes after Thermal Ablation of Colorectal Liver Metastases. radiotherapy use in lung metastases from colon-rectal cancer: The LaIT-SABR
Cancers (Basel) 2022;14:693. study. Radiother Oncol 2022;166:92-99.
12 Kurilova I, Gonzalez-Aguirre A, Beets-Tan RG, et al. Microwave Ablation in 23 Sharma A, Baker S. Duijm M, et al. Prognostic factors for local control and
the Management of Colorectal Cancer Pulmonary Metastases. Cardiovasc survival for inoperable pulmonary colorectal oligometastases treated with
Intervent Radiol 2018;41:1530-1544. stereotactic body radiotherapy. Radiother Oncol 2020;144:23-29.

Continued
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PRINCIPLES OF SURGERY AND LOCOREGIONAL THERAPIES – REFERENCES

24 Abdalla EK, Vauthey JN, Ellis LM, et al. Recurrence and outcomes following 39 Yano T, Hara N, Ichinose Y, et al. Results of pulmonary resection of metastatic
hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal cancer and its application. J Thorac Cardiovasc Surg 1993;106:875-
colorectal liver metastases. Ann Surg 2004;239:818-825; discussion 825-827. 879.
25 Resection of the liver for colorectal carcinoma metastases: a multi-institutional 40 Hendriks JM, Romijn S, Van Putte B, et al. Long-term results of surgical
study of indications for resection. Registry of Hepatic Metastases. Surgery resection of lung metastases. Acta Chir Belg 2001;101:267-272.
1988;103:278-288. 41  Adam R, Avisar E, Ariche A, et al. Five-year survival following hepatic resection
26 Hughes KS, Simon R, Songhorabodi S, et al. Resection of the liver for after neoadjuvant therapy for nonresectable colorectal. Ann Surg Oncol
colorectal carcinoma metastases: a multi-institutional study of patterns of 2001;8:347-353.
recurrence. Surgery 1986;100:278-284. 42  Rivoire M, De Cian F, Meeus P, et al. Combination of neoadjuvant
27 Fong Y, Cohen AM, Fortner JG, et al. Liver resection for colorectal metastases. chemotherapy with cryotherapy and surgical resection for the treatment
J Clin Oncol 1997;15:938-946. of unresectable liver metastases from colorectal carcinoma. Cancer
28 Nordlinger B, Quilichini MA, Parc R, et al. Surgical resection of liver metastases 2002;95:2283-2292.
from colo-rectal cancers. Int Surg 1987;72:70-72. 43 Vauthey JN, Pawlik TM, Ribero D, et al. Chemotherapy regimen predicts
29 Fong Y, Fortner J, Sun RL, et al. Clinical score for predicting recurrence after steatohepatitis and an increase in 90-day mortality after surgery for hepatic
hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive colorectal metastases. J Clin Oncol 2006;24:2065-2072.
cases. Ann Surg 1999;230:309-318; discussion 318-321. 44 Pawlik TM, Olino K, Gleisner AL, et al. Preoperative chemotherapy for
30 Giuliante F, Viganò L, De Rose AM, et al. Liver-First Approach for Synchronous colorectal liver metastases: impact on hepatic histology and postoperative
Colorectal Metastases: Analysis of 7360 Patients from the LiverMetSurvey outcome. J Gastrointest Surg 2007;11:860-868.
Registry. Ann Surg Oncol 2021;28:8198–8208. 45 Benoist S, Brouquet A, Penna C, et al. Complete response of colorectal
31  Adam R, Bismuth H, Castaing D, et al. Repeat hepatectomy for colorectal liver liver metastases after chemotherapy: does it mean cure? J Clin Oncol
metastases. Ann Surg 1997;225:51-62. 2006;24:3939-3945.
32 McAfee MK, Allen MS, Trastek VF, et al. Colorectal lung metastases: results of 46 Bartlett DL, Berlin J, Lauwers GY, et al. Chemotherapy and regional therapy of
surgical excision. Ann Thorac Surg 1992;53:780-785; discussion 785-786. hepatic colorectal metastases: expert consensus statement. Ann Surg Oncol
33 Regnard JF, Grunenwald D, Spaggiari L, et al. Surgical treatment of hepatic and 2006;13:1284-1292.
pulmonary metastases from colorectal cancers. Ann Thorac Surg 1998;66:214- 47 Pimentel-Nunes P, Libânio D, Bastiaansen BAJ, et al. Endoscopic submucosal
218; discussion 218-219. dissection for superficial gastrointestinal lesions: European Society of
34  Inoue M, Kotake Y, Nakagawa K, et al. Surgery for pulmonary metastases from Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022. Endoscopy
colorectal carcinoma. Ann Thorac Surg 2000;70:380-383. 2022;54:591-622.
35 Sakamoto T, Tsubota N, Iwanaga K, et al. Pulmonary resection for metastases 48 Endoscopic Classification Review Group. Update on the paris classification of
from colorectal cancer. Chest 2001;119:1069-1072. superficial neoplastic lesions in the digestive tract. Endoscopy 2005;37:570-
36 Rena O, Casadio C, Viano F, et al. Pulmonary resection for metastases from 578.
colorectal cancer: factors influencing prognosis. Twenty-year experience. Eur J 49 Wang AY, Hwang JH, Bhatt A, Draganov PV. AGA clinical practice update on
Cardiothorac Surg 2002;21:906-912. surveillance after pathologically curative endoscopic submucosal dissection
37  Irshad K, Ahmad F, Morin JE, Mulder DS. Pulmonary metastases from of early gastrointestinal neoplasia in the United States: Commentary.
colorectal cancer: 25 years of experience. Can J Surg 2001;44:217-221. Gastroenterology 2021;161:2030-2040.e1.
38 Ambiru S, Miyazaki M, Ito H, et al. Resection of hepatic and pulmonary 50 Moss A, Bourke MJ, Williams SJ, et al. Endoscopic mucosal resection
metastases in patients with colorectal carcinoma. Cancer 1998;82:274-278. outcomes and prediction of submucosal cancer from advanced colonic mucosal
neoplasia. Gastroenterology 2011;140:1909-1918.

Continued
Note: All recommendations are category 2A unless otherwise indicated.
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PRINCIPLES OF SURGERY AND LOCOREGIONAL THERAPIES – REFERENCES

51 Tanaka S, Kashida H, Saito Y, et al. Japan Gastroenterological Endoscopy Society guidelines for colorectal endoscopic submucosal dissection/endoscopic mucosal
resection. Dig Endosc 2020;32:219-239.
52 Kim M, Bareket R, Eleftheriadis NP, et al. Endoscopic submucosal dissection (ESD) offers a safer and more cost-effective alternative to transanal endoscopic
microsurgery (TEM). J Clin Gastroenterol 2023;57:486-489.
53 Kiriyama S, Saito Y, Matsuda T, et al. Comparing endoscopic submucosal dissection with transanal resection for non-invasive rectal tumor: A retrospective study. J
Gastroenterol Hepatol 2011;26:1028-1033.
54 Park SU, Min YW, Shin JU, et al. Endoscopic submucosal dissection or transanal endoscopic microsurgery for nonpolypoid rectal high grade dysplasia and
submucosa-invading rectal cancer. Endoscopy 2012;44:1031-1036.

Note: All recommendations are category 2A unless otherwise indicated.

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PRINCIPLES OF PERIOPERATIVE THERAPY

Not every patient with rectal cancer requires trimodality treatment—trials with adaptive designs have demonstrated some patients will have
favorable outcomes with selective usage of radiation or selective usage of surgery, based on reassessment of response during therapy.1,2
The regimens used in patients who will undergo or have undergone surgery include both concurrent chemotherapy/RT and chemotherapy
alone. Perioperative treatment is recommended for up to a total of 3 to 6 months.

Perioperative Chemotherapy:
• mFOLFOX 63,4,5
Oxaliplatin 85 mg/m2 IV, day 1,a leucovorin 400 mg/m2 IV day 1,b 5-FU 400 mg/m2 IV bolus on day 1, followed by 1200 mg/m2/day x 2 days
(total 2400 mg/m2 over 46–48 hours) continuous infusion. Repeat every 2 weeks to a total of 6 mo perioperative therapy.
• CAPEOX6,7
Oxaliplatin 130 mg/m2 IV day 1.a Capecitabine 1000 mg/m2 PO twice daily for 14 days every 3 weeks. Repeat every 3 weeks to a total of
6 months perioperative therapy.
• FOLFIRINOX8,c
Oxaliplatin 85 mg/m² IV on day 1,a leucovorin 400 mg/m² IV over 2 hours on day 1,b irinotecan 180 mg/m² IV over 30–90 minutes on day 1,
5-FU 400 mg/m² IV push day 1, 5-FU 1200 mg/m²/day x 2 days (total 2400 mg/m² over 46 hours) continuous infusion.
Repeat every 2 weeks.
• Modified FOLFIRINOX9,c
Oxaliplatin 85 mg/m² IV on day 1,a leucovorin 400 mg/m² IV over 2 hours on day 1,b irinotecan 150 mg/m² IV over 30–90 minutes on day 1,
5-FU 1200 mg/m²/day x 2 days (total 2400 mg/m² over 46 hours) continuous infusion. Repeat every 2 weeks.

Dosing Schedules for Concurrent Chemotherapy/RT:

• RT + continuous infusion 5-FU10
5-FU 225 mg/m2 IV over 24 hours daily on days 1–5 or days 1–7 for 5 weeks with RT
• RT + capecitabine11,12
Capecitabine 825 mg/m2 PO BID, Monday–Friday, on days of radiation treatment only, throughout the duration of RT (typically 28–30
treatment days)
• RT + 5-FU/leucovorin13,d
5-FU 400 mg/m2 IV bolus + leucovorin 20 mg/m2 IV bolus for 4 days during weeks 1 and 5 of RT

a Oxaliplatin may be given either over 2 hours, or may be infused over a shorter time at a rate of 1 mg/m2/min. Leucovorin infusion should match infusion time of
oxaliplatin. Cercek A, Park V, Yaeger R, et al. Faster FOLFOX: oxaliplatin can be safely infused at a rate of 1 mg/m2/min. J Oncol Pract 2016;12:e548-553.
b Leucovorin 400 mg/m2 is the equivalent of levoleucovorin 200 mg/m2.
c FOLFIRINOX is recommended instead of FOLFOXIRI because FOLFOXIRI uses a high dose of 5-FU (3,200 mg/m² over 48 hours). Patients in the United States have
been shown to have greater toxicity with 5-FU. The dose of 5-FU (2,400 mg/m² over 46 hours) is a starting dose consistent with the dose recommended in FOLFOX or
FOLFIRI and should be strongly considered for U.S. patients.
d Bolus 5-FU/leucovorin/RT is an option for patients not able to tolerate capecitabine or infusional 5-FU. References

Note: All recommendations are category 2A unless otherwise indicated.

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Rectal Cancer Discussion

PRINCIPLES OF PERIOPERATIVE THERAPY – REFERENCES

1 Schrag D, Shi Q, Weiser M, et al. Preoperative treatment of locally advanced rectal cancer. N Engl J Med 2023;389:322-334.
2 Garcia-Aguilar J, Patil S, Gollub M, et al. Organ preservation in patients with rectal adenocarcinoma treated with total neoadjuvant therapy. J Clin Oncol 2022;40:2546-
2556.
3 Andre T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 2004;350:2343-2351.
4 Cheeseman SL, Joel SP, Chester JD, et al. A ‘modified de Gramont’ regimen of fluorouracil, alone and with oxaliplatin, for advanced colorectal cancer. Br J Cancer
2002;87:393-399.
5 Maindrault-Goebel F, deGramont A, Louvet C, et al. Evaluation of oxaliplatin dose intensity in bimonthly leucovorin and 48-hour 5-fluorouracil continuous infusion
regimens (FOLFOX) in pretreated metastatic colorectal cancer. Ann Oncol 2000;11:1477-1483.
6 Schmoll HJ, Cartwright T, Tabernero J, et al. Phase III trial of capecitabine plus oxaliplatin as adjuvant therapy for stage III colon cancer: a planned safety analysis in
1,864 patients. J Clin Oncol 2007;25:102-109.
7 Haller DG, Tabernero J, Maroun J, et al. Capecitabine plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for stage III colon cancer. J Clin
Oncol 2011;29:1465-1471.
8 Conroy T, Bosset J-F, Etienne P-L, et al. Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal
cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol 2021;22:702-715.
9 Bennouna J, Andre T, Campion L, et al. Rationale and design of the IROCAS study: multicenter, international, randomized phase 3 trial comparing adjuvant modified
(m) FOLFIRINOX to mFOLFOX6 in patients with high-risk stage III (pT4 and/or N2) colon cancer-A UNICANCER GI-PRODIGE Trial. Clin Colorectal Cancer
2019;18:e69-e73.
10 O’Connell MJ, Martenson JA, Wieand HS, et al. Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after
curative surgery. N Engl J Med 1994; 331:502-507.
11 O’Connell MJ, Colangelo LH, Beart RW, et al. Capecitabine and oxaliplatin in the preoperative multimodality treatment of rectal cancer: surgical end points from
National Surgical Adjuvant Breast and Bowel Project trial R-04. J Clin Oncol 2014;32:1927-1934.
12 Hofheinz R, Wenz FK, Post S, et al. Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: A randomized, multicentre, non-
inferiority, phase 3 trial. Lancet Oncol 2012;13:579-588.
13 Tepper JE, O’Connell M, Niedzwiecki D, et al. Adjuvant therapy in rectal cancer: analysis of stage, sex, and local control--final report of Intergroup 0114. J Clin Oncol
2002;20:1744-1750.

Note: All recommendations are category 2A unless otherwise indicated.

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PRINCIPLES OF RADIATION THERAPY

General Principles
• Chemotherapy with a fluoropyrimidine in oral or continuous venous infusion form should be delivered concurrently with conventionally
fractionated RT.
• In patients with a limited number of liver or lung metastases, ablative radiotherapy to the metastatic site can be considered in highly selected cases
or in the setting of a clinical trial. Radiotherapy should not be used in the place of surgical resection. Radiotherapy should be delivered in a highly
conformal manner. The techniques can include 3D conformal RT, intensity-modulated RT (IMRT), or stereotactic body RT (SBRT).
Treatment Information
• Image-guided RT (IGRT) with kilovoltage (kV) imaging or cone-beam CT imaging should be routinely used during the course of treatment with IMRT
and SBRT.
• IMRT is preferred for reirradiation of previously treated patients with recurrent disease, patients treated postoperatively due to increased acute
or later toxicity,1 or in unique anatomical situations (eg, coverage of external iliac lymph nodes for T4 tumors invading anterior pelvic organs or
inguinal lymph nodes for low-lying tumors involving the anal canal or avoidance of small bowel).
• In patients with locally recurrent disease after prior pelvic RT, consider use of hyperfractionated pelvic re-irradiation if re-treatment is planned.2
• IORT, if available, may be considered for very close or positive margins after resection, as an additional boost, especially for patients with T4 or
recurrent cancers.
• Arterially directed catheter therapy, and in particular yttrium-90 microsphere selective internal radiation, is an option in highly selected patients
with chemotherapy-resistant/-refractory disease and with predominant hepatic metastases.
• SBRT can be used alone or in conjunction with other metastatic-directed therapies for patients with oligometastatic disease. SBRT can be
considered for larger lesions or more extensive disease, if there is sufficient uninvolved liver/lung and liver/lung radiation tolerance can be
respected. There should be no other systemic disease or it should be minimal and addressed in a comprehensive management plan. RT
dosing to consider, depending on the ability to meet normal organ constraints and underlying liver/lung function:
SBRT: 30-60 Gy (typically in 3-5 fractions).
Hypofractionation: 37.5-67.5 Gy in 10-15 fractions.

Treatment Information – Target Volumes, RT Dosing; Supportive Care REC-E 2 of 2

1 Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004;351:1731-1740.
2 Tao R, Tsai CJ, Jensen G, et al. Hyperfractionated accelerated reirradiation for rectal cancer: an analysis of outcomes and toxicity. Radiother Oncol 2017;122:146-151.

Note: All recommendations are category 2A unless otherwise indicated.

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PRINCIPLES OF RADIATION THERAPY

Treatment Information
• Target Volumes
Target volume definition should be performed per ICRU 50 recommendations.
Gross tumor volume (GTV) should include all primary tumor and involved lymph nodes, using information from physical examination,
endoscopic findings, diagnostic imaging, and the simulation planning study for delineation. Clinical target volume (CTV) should include the
GTV plus areas at risk for microscopic spread from the primary tumor and at-risk nodal areas. A consensus atlas may be helpful to review when
defining elective nodal CTVs.3
At-risk nodal regions include mesorectal, presacral, posterior obturator nodes, and internal iliac nodes. The external iliac nodes should also be
included for T4 tumors involving anterior structures. Consider including the inguinal nodes for low-lying tumors involving the anal canal.
Fusion of the pelvic MRI is strongly recommended to optimally define gross disease.
If using 3D conformal radiation, multiple RT fields should be used (generally a 3- or 4-field technique). Prone positioning, full bladder, and other
techniques to minimize the volume of small bowel in the fields are encouraged.
For postoperative patients treated by abdominoperineal resection, the perineal wound should be included within the fields.
• RT Dosing
45–54 Gy in 25–30 fractions to the pelvis.
◊ For resectable cancers, after 45 Gy a tumor bed boost with a 2-cm margin of 5.4 to 9.0 Gy in 3 to 5 fractions could be considered for
preoperative radiation.
◊ Small bowel max point dose should be limited to 50 Gy, V45 Gy should be <195 cc for a bowel bag avoidance, or V15 should be <120 cc for
individual small bowel loops.
◊ For unresectable cancers, doses higher than 54 Gy may be required, if technically feasible.
Short-course RT (25 Gy in 5 fractions) can also be considered for patients for preoperative radiation.
◊ For high-risk rectal cancer (clinical tumor stage cT4a or cT4b, EMVI, clinical nodal stage cN2, involved MRF, [tumor or lymph node 1
mm or less from the MRF] or enlarged lateral lymph nodes considered to be metastatic), the 5-year follow-up of the RAPIDO trial now
indicates a statistically higher locoregional recurrence rate (10%) in the experimental arm of short-course RT → chemotherapy → surgery
versus control arm (6%) of chemoRT → surgery → adjuvant chemotherapy.4
Supportive Care
• Patients should be considered for vaginal dilators and instructed on the symptoms of vaginal stenosis.
• Patients of childbearing potential should be counseled about the effects of premature menopause and consideration should be given to referral for
discussion of hormone replacement strategies.
• Patients of childbearing potential should be counseled that an irradiated uterus cannot carry a fetus to term.
• Patients should be counseled on sexual dysfunction, potential for future low testosterone levels, and infertility risks and given information
regarding sperm banking or oocyte, egg, or ovarian tissue banking, as appropriate, prior to treatment.
3 Myerson RJ, Garofalo MC, El Naqa I, et al. Elective clinical target volumes for conformal therapy in anorectal cancer: a radiation therapy oncology group consensus
panel contouring atlas. Int J Radiat Oncol Biol Phys 2009;74:824-830.
4 Dijkstra E, Nilsson PJ, Hospers GAP, et al. Locoregional failure during and after short-course radiotherapy followed by chemotherapy and surgery compared to long-
course chemoradiotherapy and surgery - A five-year follow-up of the RAPIDO trial. Ann Surg 2023;278:e766-e772.

Note: All recommendations are category 2A unless otherwise indicated.

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Rectal Cancer Discussion

pMMR/MSS CONTINUUM OF CARE - SYSTEMIC THERAPY FOR ADVANCED OR METASTATIC DISEASEa,b

(or dMMR/MSI-H
or POLE/POLD1 INITIAL THERAPYc
mutation that is
ineligible for or
progressed on FOLFOXd ± bevacizumabe
checkpoint or
inhibitor CAPEOXd ± bevacizumabe
or Progression REC-F 2 of 11
immunotherapy)
FOLFOXd + (cetuximab or panitumumab)f
(KRAS/NRAS/BRAF WTg)
Intensive or
therapy CAPEOXd + (cetuximab or panitumumab)f
recommended (KRAS/NRAS/BRAF WTg)
or
FOLFIRIh ± bevacizumabe
or Progression REC-F 2 of 11
FOLFIRIh + (cetuximab or panitumumab)f
(KRAS/NRAS/BRAF WTg)
or
FOLFIRINOXd,h,i,j ± bevacizumabe Progression REC-F 2 of 11

Consider initial
Improvement in therapy as abovem
5-FU ± leucovorin ± bevacizumabe
functional status or
or
If previous
Capecitabine ± bevacizumabe
fluoropyrimidine,
or
Intensive see REC-F 2 of 11
(Cetuximab or panitumumab)f Progression
therapy NOT
(category 2B) (KRAS/NRAS/BRAF WTg)
recommended Best supportive
or
(Trastuzumabk + [pertuzumab or lapatinib or tucatinib])l No improvement in care
(HER2-amplified and RAS and BRAF WT)f functional status NCCN Guidelines
for Palliative Care
For dMMR/MSI-H or POLE/POLD1 mutation, see REC-F 3 of 11
Footnotes REC-F 4 of 11

Note: All recommendations are category 2A unless otherwise indicated.

REC-F
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Rectal Cancer Discussion

CONTINUUM OF CARE - SYSTEMIC THERAPY FOR ADVANCED OR METASTATIC DISEASEa,b,n

pMMR/MSS (or dMMR/MSI-H or POLE/POLD1 mutation that is ineligible for or progressed on checkpoint inhibitor immunotherapy)
SECOND-LINE AND SUBSEQUENT THERAPY OPTIONS (if not previously given)c,o
Previous oxaliplatin-based therapy without Previous therapy with oxaliplatin and irinotecan Biomarker-directed therapy
irinotecan
• FOLFIRIh or irinotecanh • If KRAS/NRAS/BRAF WTg: • BRAF V600E mutation positivef
• FOLFIRIh + (bevacizumabe,p [preferred] or (Cetuximab or panitumumab)f,r ± irinotecanh Encorafenib + (cetuximab or panitumumab)s
ziv-afliberceptp,q or ramucirumabp,q)
• Irinotecanh + (bevacizumabe,p [preferred] or • Biomarker-directed therapy (see Biomarker- • HER2-amplified and RAS and BRAF WTf
ziv-afliberceptp,q or ramucirumabp,q) directed therapy) (Trastuzumabk + [pertuzumab or lapatinib or
tucatinib])l
• If KRAS/NRAS/BRAF WTg: • For disease that has progressed through all
FOLFIRIh + (cetuximab or panitumumab)f,r available regimens: • HER2-amplified (IHC 3+)
(Cetuximab or panitumumab)f,r ± irinotecanh Fruquintinib Fam-trastuzumab deruxtecan-nxkit
Regorafenib
• Biomarker-directed therapy (see Biomarker- Trifluridine + tipiracil ± bevacizumabe • KRAS G12C mutation positivef
directed therapy) (bevacizumab combo preferred) (Sotorasib or adagrasib)u + (cetuximab or
panitumumab)
• Best supportive care (NCCN Guidelines for
Palliative Care) • NTRK gene fusion-positive
Previous irinotecan-based therapy without Previous therapy without oxaliplatin or irinotecan Entrectinib
oxaliplatin Larotrectinib
Repotrectinibv
• FOLFOXd or CAPEOXd • FOLFOXd or CAPEOXd
• FOLFOXd + bevacizumabe • (FOLFOX or CAPEOX)d + bevacizumabe • RET gene fusion-positive
• CAPEOXd + bevacizumabe • FOLFIRIh or irinotecanh Selpercatinib
• (FOLFIRI or irinotecan)h + (bevacizumabe,p
g
• If KRAS/NRAS/BRAF WT : [preferred] or ziv-afliberceptp,q or
d
FOLFOX + (cetuximab or panitumumab) f ramucirumabp,q)
d
CAPEOX + (cetuximab or panitumumab) f • Irinotecanh + oxaliplatind ± bevacizumabe
(Cetuximab or panitumumab) ± irinotecan • FOLFIRINOXd,j ± bevacizumabe
f,r h

• Biomarker-directed therapy (see Biomarker- • If KRAS/NRAS/BRAF WTg:

directed therapy) FOLFIRIh + (cetuximab or panitumumab)f,r
(Cetuximab or panitumumab)f,r ± irinotecanh
• Biomarker-directed therapy (see Biomarker-
directed therapy)
Footnotes
REC-F 4 of 11
Note: All recommendations are category 2A unless otherwise indicated.
REC-F
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dMMR/MSI-H Rectal Cancer Discussion

CONTINUUM OF CARE - SYSTEMIC THERAPY FOR ADVANCED OR METASTATIC DISEASEa,b

dMMR/MSI-H or POLE/POLD1 mutation

Any line of therapy

Surveillance (REC-10A)
Candidate for or
immunotherapy Surgery ± RT
Checkpoint inhibitor Re-evaluate disease
and no prior or
immunotherapy*,w,x,y status every 2–3 mo
immunotherapy Continue immunotherapy
received or
Systemic therapy (REC-F 1 of 11)

Prior
immunotherapy Systemic therapy (REC-F 1 of 11)
received

Footnotes REC-F 4 of 11
* Patients should be followed closely for 10 weeks to assess for response.

Note: All recommendations are category 2A unless otherwise indicated.

REC-F
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Rectal Cancer Discussion

SYSTEMIC THERAPY FOR ADVANCED OR METASTATIC DISEASE – FOOTNOTES

a For chemotherapy references, see Chemotherapy Regimens and References (REF-F [5 of 11]).
b For infection risk, monitoring, and prophylaxis recommendations for targeted therapies, see INF-A in the NCCN Guidelines for Prevention and Treatment of Cancer-
Related Infections.
c C/A/P CT with contrast or chest CT and abdomen/pelvis MRI with contrast to monitor progress of therapy. FDG-PET/CT should not be used. See Principles of Imaging
(REC-A).
d Discontinuation of oxaliplatin should be strongly considered after 3 to 4 months of therapy (or sooner for unacceptable neurotoxicity) while maintaining other agents
until time of progression. Oxaliplatin may be reintroduced if it was discontinued for neurotoxicity rather than for disease progression.
e An FDA-approved biosimilar is an appropriate substitute for bevacizumab.
f Principles of Pathologic Review (REC-B 5 of 11).
g Patients with BRAF mutations other than V600E may be considered for anti-EGFR therapy.
h Irinotecan should be used with caution in patients with Gilbert syndrome or elevated serum bilirubin. There is a commercially available test for UGT1A1. Guidelines for
use in clinical practice have not been established.
i FOLFIRINOX should be strongly considered for patients with excellent performance status.
j FOLFIRINOX is recommended instead of FOLFOXIRI because FOLFOXIRI uses a high dose of 5-FU (3,200 mg/m² over 48 hours). Patients in the United States have
been shown to have greater toxicity with 5-FU. The dose of 5-FU (2,400 mg/m² over 46 hours) is a starting dose consistent with the dose recommended in FOLFOX or
FOLFIRI and should be strongly considered for U.S. patients.
k An FDA-approved biosimilar is an appropriate substitute for trastuzumab.
l If no previous treatment with HER2 inhibitor.
m The use of single-agent capecitabine after progression on a fluoropyrimidine-containing regimen has been shown to be ineffective; therefore, this is not recommended.
n Arterially directed catheter therapy, and in particular yttrium-90 microsphere selective internal radiation, is an option in highly selected patients with chemotherapy-
resistant/-refractory disease and with predominant hepatic metastases. See Principles of Surgery and Locoregional Therapies (REC-C).
o If patients had therapy stopped for reasons other than progression (eg, cumulative toxicity, elective treatment break, patient preference), rechallenge is an option at
time of progression.
p Bevacizumab is the preferred anti-angiogenic agent based on toxicity and/or cost.
q There are no data to suggest activity of FOLFIRI-ziv-aflibercept or FOLFIRI-ramucirumab in a patient who has progressed on FOLFIRI-bevacizumab, or vice versa.
Ziv-aflibercept and ramucirumab have only shown activity when given in conjunction with FOLFIRI in FOLFIRI-naïve patients.
r Cetuximab or panitumumab are recommended in combination with irinotecan-based therapy or as single-agent therapy for patients who cannot tolerate irinotecan.
s In the second-line setting for BRAF V600E mutation-positive tumors, there is phase 3 evidence for better efficacy with targeted therapies over FOLFIRI.
t Some activity was seen after a previous HER2-targeted regimen. May not be indicated in patients with underlying lung issues due to lung toxicity (3.5% report of drug-
related deaths from interstitial lung disease on the DESTINY-CRC01 trial).
u If patient is unable to tolerate EGFR inhibitor due to toxicity, single-agent adagrasib or sotorasib can be considered.
v On the TRIDENT-1 trial, repotrectinib showed activity in both NTRK TKI-naïve and NTRK TKI-pretreated patients.
w Checkpoint inhibitor therapy options include: nivolumab ± ipilimumab, pembrolizumab, or dostarlimab-gxly. Nivolumab + ipilimumab combination is category 2B when
intensive therapy is not recommended due to toxicity concerns.
x NCCN Guidelines for Management of Immunotherapy-Related Toxicities.
y If disease response, consider discontinuing checkpoint inhibitor after 2 years of treatment.

Note: All recommendations are category 2A unless otherwise indicated.

REC-F
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Rectal Cancer Discussion

SYSTEMIC THERAPY FOR ADVANCED OR METASTATIC DISEASE - CHEMOTHERAPY REGIMENS

mFOLFOX 61,2,3 CAPEOX + bevacizumab8,e,bb
Oxaliplatin 85 mg/m2 IV day 1z Oxaliplatin 130 mg/m2 IV day 1z
Leucovorin 400 mg/m2 IV day 1aa Capecitabine 1000cc mg/m2 PO twice daily for 14 days
5-FU 400 mg/m2 IV bolus on day 1, followed by 1200 mg/m2/day x 2 days Bevacizumab 7.5 mg/kg IV day 1
(total 2400 mg/m2 over 46–48 hours) IV continuous infusion Repeat every 3 weeks
Repeat every 2 weeks
CAPEOX + cetuximab9-11 (KRAS/NRAS/BRAF WT)
mFOLFOX 74 Cetuximab 400 mg/m2 IV over 2 hours first infusion, followed by 250 mg/m2 IV
Oxaliplatin 85 mg/m2 IV day 1z over 60 minutes weekly
Leucovorin 400 mg/m2 IV day 1aa or Cetuximab 500 mg/m2 IV over 2 hours, day 1, every 2 weeks
5-FU 1200 mg/m2/day x 2 days (total 2400 mg/m2 over 46–48 hours) (preferred for every 2 weeks)
IV continuous infusion
Repeat every 2 weeks CAPEOX + panitumumab9-11 (KRAS/NRAS/BRAF WT)
Panitumumab 6 mg/kg IV over 60 minutes, day 1
FOLFOX + bevacizumab5,e,bb Repeat every 2 weeks
Bevacizumab 5 mg/kg IV, day 1
Repeat every 2 weeks FOLFIRI12,13
Irinotecan 180 mg/m2 IV over 30–90 minutes, day 1
FOLFOX + panitumumab6 (KRAS/NRAS/BRAF WT) Leucovorinaa 400 mg/m2 IV infusion to match duration of irinotecan infusion,
Panitumumab 6 mg/kg IV over 60 minutes, day 1 day 1
Repeat every 2 weeks 5-FU 400 mg/m2 IV bolus day 1, followed by 1200 mg/m2/day x 2 days (total
2400 mg/m2 over 46–48 hours) continuous infusion
FOLFOX + cetuximab7 (KRAS/NRAS/BRAF WT) Repeat every 2 weeks
Cetuximab 400 mg/m2 IV over 2 hours first infusion,
followed by 250 mg/m2 IV over 60 minutes weekly FOLFIRI + bevacizumab14,e,bb
or Cetuximab 500 mg/m2 IV over 2 hours, day 1, every 2 weeks Bevacizumab 5 mg/kg IV, day 1
(preferred for every 2 weeks) Repeat every 2 weeks
CAPEOX8 FOLFIRI + cetuximab (KRAS/NRAS/BRAF WT)
Oxaliplatin 130 mg/m2 IV day 1z Cetuximab 400 mg/m2 IV over 2 hours first infusion,
Capecitabine 1000cc mg/m2 twice daily PO for 14 days followed by 250 mg/m2 IV over 60 minutes weekly15
Repeat every 3 weeks or Cetuximab 500 mg/m2 IV over 2 hours, day 1, every 2 weeks16 (preferred
for every 2 weeks)

bb Bevacizumab may be safely given at a rate of 0.5 mg/kg/min (5 mg/kg over 10

e An FDA-approved biosimilar is an appropriate substitute for bevacizumab.
minutes and 7.5 mg/kg over 15 minutes).
cc The majority of safety and efficacy data for this regimen have been developed
z Oxaliplatin may be given either over 2 hours, or may be infused over a shorter
in Europe, where a capecitabine starting dose of 1000 mg/m2 twice daily for 14
time at a rate of 1 mg/m2/min. Leucovorin infusion should match infusion time of days, repeated every 21 days, is standard. Evidence suggests that North American
oxaliplatin. Cercek A, Park V, Yaeger R, et al. Faster FOLFOX: oxaliplatin can be patients may experience greater toxicity with capecitabine (as well as with other
safely infused at a rate of 1 mg/m2/min. J Oncol Pract 2016;12:e548-553. fluoropyrimidines) than European patients, and may require a lower dose of
aa Leucovorin 400 mg/m2 is the equivalent of levoleucovorin 200 mg/m2. capecitabine. Continued
References
Note: All recommendations are category 2A unless otherwise indicated.
REC-F
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SYSTEMIC THERAPY FOR ADVANCED OR METASTATIC DISEASE - CHEMOTHERAPY REGIMENS

FOLFIRI + panitumumab17 (KRAS/NRAS/BRAF WT) IROX25
Panitumumab 6 mg/kg IV over 60 minutes, day 1 Oxaliplatin 85 mg/m2 IV,z
Repeat every 2 weeks followed by irinotecan 200 mg/m2 over 30–90 minutes every 3 weeks

FOLFIRI + ziv-aflibercept18 IROX + bevacizumabe,bb

Ziv-aflibercept 4 mg/kg IV over 60 minutes, day 1 Bevacizumab 7.5 mg/kg IV on day 1
Repeat every 2 weeks Repeat every 3 weeks

FOLFIRI + ramucirumab19 Bolus or infusional 5-FU/leucovorin

Ramucirumab 8 mg/kg over 60 minutes, day 1 Roswell Park regimen26
Repeat every 2 weeks Leucovorin 500 mg/m2 IV over 2 hours, days 1, 8, 15, 22, 29, and 36
5-FU 500 mg/m2 IV bolus 1 hour after start of leucovorin,
FOLFIRINOX20,j days 1, 8, 15, 22, 29, and 36
Oxaliplatin 85 mg/m² IV on day 1,z leucovorin 400 mg/m² IV over 2 Repeat every 8 weeks
hours on day 1, irinotecan 165–180 mg/m² IV over 30–90 minutes on
day 1, 5-FU 400 mg/m² IV push day 1, 5-FU 1200 mg/m²/day x 2 days Simplified biweekly infusional 5-FU/leucovorin (sLV5FU2)12
(total 2400 mg/m² over 46 hours) continuous infusion. Leucovorinaa 400 mg/m2 IV over 2 hours on day 1,
Repeat every 2 weeks followed by 5-FU bolus 400 mg/m2 followed by 1200 mg/m2/day x 2
days (total 2400 mg/m2 over 46–48 hours) continuous infusion
Repeat every 2 weeks
Modified FOLFIRINOX21-23,j Weekly Leucovorin 20 mg/m2 IV over 2 hours on day 1, 5-FU 500 mg/
Oxaliplatin 85 mg/m² IV on day 1,z leucovorin 400 mg/m² IV over 2 m2 IV bolus injection 1 hour after the start of leucovorin. Repeat
hours on day 1, irinotecan 150 mg/m² IV over 30–90 minutes on day weekly27
1, 5-FU 1200 mg/m²/day x 2 days (total 2400 mg/m² over 46 hours) or
continuous infusion. Repeat every 2 weeks 5-FU 2600 mg/m2 by 24-hour infusion plus leucovorin 500 mg/m2
Repeat every week27
FOLFIRINOX or mFOLFIRINOX + bevacizumab24,e,bb
Bevacizumab 5 mg/kg IV, day 1
Repeat every 2 weeks

e An FDA-approved biosimilar is an appropriate substitute for bevacizumab.

j FOLFIRINOX is recommended instead of FOLFOXIRI because FOLFOXIRI uses a high dose of 5-FU (3,200 mg/m² over 48 hours). Patients in the United States have
been shown to have greater toxicity with 5-FU. The dose of 5-FU (2,400 mg/m² over 46 hours) is a starting dose consistent with the dose recommended in FOLFOX or
FOLFIRI and should be strongly considered for U.S. patients.
z Oxaliplatin may be given either over 2 hours, or may be infused over a shorter time at a rate of 1 mg/m2/min. Leucovorin infusion should match infusion time of
oxaliplatin. Cercek A, Park V, Yaeger R, et al. Faster FOLFOX: oxaliplatin can be safely infused at a rate of 1 mg/m2/min. J Oncol Pract 2016;12:e548-553.
aa Leucovorin 400 mg/m2 is the equivalent of levoleucovorin 200 mg/m2.
bb Bevacizumab may be safely given at a rate of 0.5 mg/kg/min (5 mg/kg over 10 minutes and 7.5 mg/kg over 15 minutes). Continued
References
Note: All recommendations are category 2A unless otherwise indicated.
REC-F
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SYSTEMIC THERAPY FOR ADVANCED OR METASTATIC DISEASE - CHEMOTHERAPY REGIMENS

Bolus or infusional 5-FU + bevacizumabe,bb Irinotecan + bevacizumab34,e,bb
Bevacizumab 5 mg/kg IV on day 1 Irinotecan 180 mg/m2 IV, day 1
Repeat every 2 weeks Bevacizumab 5 mg/kg IV, day 1
Repeat every 2 weeks
Capecitabine28,cc or
Capecitabine 850–1250 mg/m2 PO twice daily for 14 days Irinotecan 300–350 mg/m2 IV, day 1
Repeat every 3 weeks Bevacizumab 7.5 mg/kg IV, day 1
Repeat every 3 weeks
Capecitabine + bevacizumab29,e,bb
Bevacizumab 7.5 mg/kg IV, day 1 Irinotecan + ramucirumab19
Repeat every 3 weeks Ramucirumab 8 mg/kg IV over 60 minutes every 2 weeks

Irinotecan Irinotecan + ziv-aflibercept

Irinotecan 125 mg/m2 IV over 30–90 minutes, days 1 and 8 Irinotecan 180 mg/m2 IV, day 1
Repeat every 3 weeks30,31 Ziv-aflibercept 4 mg/kg IV, day 1
or Irinotecan 180 mg/m2 IV over 30–90 minutes, day 1 Repeat every 2 weeks
Repeat every 2 weeks
or Irinotecan 300–350 mg/m2 IV over 30–90 minutes, day 1 Cetuximab (KRAS/NRAS/BRAF WT)
Repeat every 3 weeks Cetuximab 400 mg/m2 first infusion, followed by 250 mg/m2 IV
weekly32
Irinotecan + cetuximab (KRAS/NRAS/BRAF WT) or Cetuximab 500 mg/m2 IV over 2 hours, day 1, every 2 weeks16
Cetuximab 400 mg/m2 first infusion, followed by 250 mg/m2 IV (preferred for every 2 weeks)
weekly32
or Cetuximab 500 mg/m2 IV over 2 hours, day 1, every 2 weeks16 Panitumumab35 (KRAS/NRAS/BRAF WT)
(preferred for every 2 weeks) Panitumumab 6 mg/kg IV over 60 minutes every 2 weeks

Irinotecan + panitumumab17,33 Regorafenib

Regorafenib 160 mg PO daily on days 1–2136
(KRAS/NRAS/BRAF WT) or
Panitumumab 6 mg/kg IV over 60 minutes every 2 weeks First cycle: Regorafenib 80 mg PO daily on days 1–7, followed by
120 mg PO daily on days 8–14, followed by 160 mg PO daily on days
15–2137
Subsequent cycles: Regorafenib 160 mg PO daily on days 1–21
Repeat every 28 days

e An FDA-approved biosimilar is an appropriate substitute for bevacizumab.

bb Bevacizumab may be safely given at a rate of 0.5 mg/kg/min (5 mg/kg over 10 minutes and 7.5 mg/kg over 15 minutes).
cc The majority of safety and efficacy data for this regimen have been developed in Europe, where a capecitabine starting doseof 1000 mg/m2 twice daily for 14
days, repeated every 21 days, is standard. Evidence suggests that North American patients may experience greater toxicity with capecitabine (as well as with other
fluoropyrimidines) than European patients, and may require a lower dose of capecitabine. Continued
References
Note: All recommendations are category 2A unless otherwise indicated.
REC-F
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SYSTEMIC THERAPY FOR ADVANCED OR METASTATIC DISEASE - CHEMOTHERAPY REGIMENS

Trifluridine + tipiracil ± bevacizumabe,38,39 Fam-trastuzumab deruxtecan-nxki47 (HER2-amplified, IHC 3+)
Trifluridine + tipiracil 35 mg/m2 up to a maximum dose of 80 mg per dose Fam-trastuzumab deruxtecan-nxki 5.4 mg/kg IV on day 1
(based on the trifluridine component) Repeat every 21 days
PO twice daily days 1–5 and 8–12
Bevacizumab 5 mg/kg on days 1 and 15 Encorafenib + cetuximab48-50
Repeat every 28 days (BRAF V600E mutation positive)
Encorafenib 300 mg PO daily
Pembrolizumab40 (dMMR/MSI-H or POLE/POLD1 mutation) Cetuximab 400 mg/m2 IV followed by 250 mg/m2 IV weekly
Pembrolizumab 2 mg/kg IV every 3 weeks or Cetuximab 500 mg/m2 IV every 2 weeks
or Pembrolizumab 200 mg IV every 3 weeks
or Pembrolizumab 400 mg IV every 6 weeks Encorafenib + panitumumab48-50
(BRAF V600E mutation positive)
Nivolumab41 (dMMR/MSI-H or POLE/POLD1 mutation) Encorafenib 300 mg PO daily
Nivolumab 3 mg/kg every 2 weeks Panitumumab 6 mg/kg IV every 14 days
or Nivolumab 240 mg IV every 2 weeks
or Nivolumab 480 mg IV every 4 weeks Larotrectinib51 (NTRK gene fusion-positive)
100 mg PO twice daily
Nivolumab + ipilimumab42 (dMMR/MSI-H or POLE/POLD1 mutation)
Nivolumab 3 mg/kg (30-minute IV infusion) and ipilimumab 1 mg/kg Entrectinib52 (NTRK gene fusion-positive)
(30-minute IV infusion) once every 3 weeks for four doses, followed by 600 mg PO once daily
Nivolumab 3 mg/kg IV or nivolumab 240 mg IV every 2 weeks or Nivolumab
480 mg IV every 4 weeks Repotrectinib53 (NTRK gene fusion-positive)
160 mg PO daily for first 14 days,
Dostarlimab-gxly43 (dMMR/MSI-H or POLE/POLD1 mutation) Then increase to 160 mg PO twice daily
Dostarlimab-gxly 500 mg IV every 3 weeks for 4 doses followed by 1000 mg
IV every 6 weeks Selpercatinib54 (RET gene fusion-positive)
Patients ≥50 kg: 160 mg PO twice daily
Trastuzumabk + pertuzumab44 Patients <50 kg: 120 mg PO twice daily
(HER2-amplified and RAS and BRAF WT)
Trastuzumab 8 mg/kg IV loading dose on day 1 of cycle 1, Adagrasib + cetuximab55 (KRAS G12C mutation positive)
followed by 6 mg/kg IV every 21 days Adagrasib 600 mg PO BID
Pertuzumab 840 mg IV loading dose on day 1 of cycle 1, Cetuximab 500 mg/m2 IV every 2 weeks
followed by 420 mg IV every 21 days
Adagrasib + panitumumab (KRAS G12C mutation positive)
Trastuzumabk + lapatinib45 Adagrasib 600 mg PO BID
(HER2-amplified and RAS and BRAF WT) Panitumumab 6 mg/kg IV every 2 weeks
Trastuzumab 4 mg/kg IV loading dose on day 1 of cycle 1,
followed by 2 mg/kg IV weekly Sotorasib + cetuximab (KRAS G12C mutation positive)
Lapatinib 1000 mg PO daily Sotorasib 960 mg PO daily
Cetuximab 500 mg/m2 IV every 2 weeks
Trastuzumabk + tucatinib46
(HER2-amplified and RAS and BRAF WT), Sotorasib + panitumumab56 (KRAS G12C mutation positive)
Trastuzumab 8 mg/kg IV loading dose on day 1 of cycle 1, Sotorasib 960 mg PO daily
followed by 6 mg/kg IV every 21 days Panitumumab 6 mg/kg IV every 2 weeks
Tucatinib 300 mg PO twice daily
Fruquintinib57
5 mg PO daily on days 1–21
Repeat every 28 days
e An FDA-approved biosimilar is an appropriate substitute for bevacizumab.
k An FDA-approved biosimilar is an appropriate substitute for trastuzumab.
References
Note: All recommendations are category 2A unless otherwise indicated.
REC-F
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Rectal Cancer Discussion

SYSTEMIC THERAPY FOR ADVANCED OR METASTATIC DISEASE – REFERENCES

1 deGramont A, 11 Maughan T, Adams RA, Smith CG, et al. Addition of cetuximab to oxaliplatin-
Figer A, Seymour M, et al. Leucovorin and fluorouracil with or
without oxaliplatin as first-line treatment in advanced rectal cancer. J Clin Oncol based first-line combination chemotherapy for treatment of advanced
2000;18:2938-2947. colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet
2 Cheeseman SL, Joel SP, Chester JD, et al. A ‘modified de Gramont’ regimen 2011;377:2103-2114.
12 Andre T, Louvet C, Maindrault-Goebel F, et al. CPT-11 (irinotecan) addition
of fluorouracil, alone and with oxaliplatin, for advanced colorectal cancer. Br J
Cancer 2002;87:393-399. to bimonthly, high-dose leucovorin and bolus and continuous-infusion
3 Maindrault-Goebel F, deGramont A, Louvet C, et al. Evaluation of oxaliplatin dose 5-fluorouracil (FOLFIRI) for pretreated metastatic colorectal cancer. Eur J Cancer
intensity in bimonthly leucovorin and 48-hour 5-fluorouracil continuous infusion 1999;35:1343-1347.
13 Fuchs CS, Marshall J, Mitchell E, et al. Randomized, controlled trial of irinotecan
regimens (FOLFOX) in pretreated metastatic colorectal cancer. Ann Oncol
2000;11:1477-1483. plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic
4 Hochster HS, Grothey A, Hart L, et al. Improved time to treatment failure with an colorectal cancer: results from the BICC-C Study. J Clin Oncol 2007;25:4779-
intermittent oxaliplatin strategy: results of CONcePT. Ann Oncol 2014;25:1172- 4786.
14 Heinemann V, von Weikersthal LF, Decker T, et al. FOLFIRI plus cetuximab
1178.
5 Emmanouilides C, Sfakiotaki G, Androulakis N, et al. Front-line bevacizumab in versus FOLFIRI plus bevacizumab as first-line treatment for patients with
combination with oxaliplatin, leucovorin and 5-fluorouracil (FOLFOX) in patients metastatic colorectal cancer (FIRE-3): a randomized, open-label, phase 3 trial.
with metastatic colorectal cancer: a multicenter phase II study. BMC Cancer Lancet Oncol 2014;15:1065-1075.
15 Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and
2007;7:91.
6 Douillard JY, Siena S, Cassidy J, et al. Randomized, phase III trial of cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N
panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) Engl J Med 2004;351:337-345.
16 Martín-Martorell P, Roselló S, Rodríguez-Braun E, et al. Biweekly cetuximab
versus FOLFOX4 alone as first-line treatment in patients with previously
untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol and irinotecan in advanced colorectal cancer patients progressing after at least
2010;28:4697-4705. one previous line of chemotherapy: results of a phase II single institution trial. Br
7 Venook AP, Niedzwiecki D, Lenz HJ, et al. Effect of first-line chemotherapy J Cancer 2008;99:455-458.
17 Peeters M, Price TJ, Cervantes A, et al. Randomized phase III study of
combined with cetuximab or bevacizumab on overall survival in patients with
KRAS wild-type advanced or metastatic colorectal cancer: A randomized clinical panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared
trial. JAMA 2017;317:2392-2401. with FOLFIRI alone as second-line treatment in patients with metastatic
8 Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with colorectal cancer. J Clin Oncol 2010;28:4706-4713.
18 Van Cutsem E, Tabernero J, Lakomy R, et al. Addition of aflibercept to
oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal
cancer: a randomized phase III study. J Clin Oncol 2008;26:2013-2019. fluorouracil, leucovorin, and irinotecan improves survival in a phase III
9 Iwamoto S, Maeda H, Hazama S, et al. Efficacy of CapeOX plus cetuximab randomized trial in patients with metastatic colorectal cancer previously treated
treatment as a first-line therapy for patients with extended RAS/BRAF/PIK3CA with an oxaliplatin-based regimen. J Clin Oncol 2012;30:3499-3506.
19 Tabernero J, Yoshino T, Cohn AL, et al. Ramucirumab versus placebo in
wild-type advanced or metastatic colorectal cancer. J Cancer 2018;9:4092-4098.
10 Bridgewater JA, Pugh SA, Maishman T, et al. Systemic chemotherapy with or combination with second-line FOLFIRI in patients with metastatic colorectal
without cetuximab in patients with resectable colorectal liver metastasis (New carcinoma that progressed during or after first-line therapy with bevacizumab,
EPOC): long-term results of a multicentre, randomised, controlled, phase 3 trial. oxaliplatin, and a fluoropyrimidine (RAISE): a randomized, double-blind,
Lancet Oncol 2020;21:398-411. multicentre, phase 3 study. Lancet Oncol 2015;16:499-508.
20 Conroy T, Bosset J-F, Etienne P-L, et al. Neoadjuvant chemotherapy with
FOLFIRINOX and preoperative chemoradiotherapy for patients with locally
advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised,
open-label, phase 3 trial. Lancet Oncol 2021;22:702-715.
Continued
Note: All recommendations are category 2A unless otherwise indicated.
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SYSTEMIC THERAPY FOR ADVANCED OR METASTATIC DISEASE – REFERENCES

21 Bennouna J, Andre T, Campion L, et al. Rationale and design of the IROCAS 31 Fuchs CS, Moore MR, Harker G, et al. Phase III comparison of two irinotecan
study: multicenter, international, randomized phase 3 trial comparing adjuvant dosing regimens in second-line therapy of metastatic colorectal cancer. J Clin
modified (m) FOLFIRINOX to mFOLFOX6 in patients with high-risk stage III Oncol 2003;21:807-814.
(pT4 and/or N2) colon cancer-A UNICANCER GI-PRODIGE Trial. Clin Colorectal 32 Van Cutsem E, Tejpar S, Vanbeckevoort D, et al. Intrapatient cetuximab dose
Cancer 2019;18:e69-e73. escalation in metastatic colorectal cancer according to the grade of early skin
22 Lamarca A, Foster L, Valle J, et al. FOLFIRINOX or FOLFOXIRI in locally reactions: the randomized EVEREST study. J Clin Oncol 2012;30:2861-2868.
advanced duodenal adenocarcinoma: are we missing out? ESMO Open 33 Andre T, Blons H, Mabro M, et al. Panitumumab combined with irinotecan for
2020;5:e000633. patients with KRAS wild-type metastatic colorectal cancer refractory to standard
23 Broquet A, Bachet JB, Huguet F, et al. NORAD01-GRECCAR16 multicenter chemotherapy: a GERCOR efficacy, tolerance, and translational molecular study.
phase III non-inferiority randomized trial comparing preoperative modified Ann Oncol 2013;24:412-419.
FOLFIRINOX without irradiation to radiochemotherapy for resectable locally 34 Yildiz R, Buyukberber S, Uner A, et al. Bevacizumab plus irinotecan-based
advanced rectal cancer (intergroup FRENCH-GRECCAR-PRODIGE trial). BMC therapy in metastatic colorectal cancer patients previously treated with oxaliplatin-
Cancer 2020;20:485. based regimens. Cancer Invest 2010;28:33-37.
24 Cremolini C, Loupakis F, Antoniotti C, et al. FOLFOXIRI plus bevacizumab 35 Van Cutsem E, Peeters M, Siena S, et al. Open-label phase III trial of
versus FOLFIRI plus bevacizumab as first-line treatment of patients with panitumumab plus best supportive care compared with best supportive care
metastatic colorectal cancer: updated overall survival and molecular subgroup alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin
analyses of the open-label, phase 3 TRIBE study. Lancet Oncol 2015;16:1306- Oncol 2007;25:1658-1664.
1315. 36 Grothey A, Van Cutsem E, Sobrero A, et al. Regorafenib monotherapy for
25 Haller DG, Rothenberg ML, Wong AO, et al. Oxaliplatin plus irinotecan previously treated metastatic colorectal cancer (CORRECT): an international,
compared with irinotecan alone as second-line treatment after single agent multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2013;381:303-
fluoropyrimidine therapy for metastatic colorectal carcinoma. J Clin Oncol 312.
2008;26:4544-4550. 37 Bekaii-Saab, TS, Ou F-S, Ahn DH, et al. Regorafenib-dose optimisation in
26Wolmark N, Rockette H, Fisher B, et al. The benefit of leucovorin-modulated patients with refractory metastatic colorectal cancer (reDOS): a randomised,
fluorouracil as postoperative adjuvant therapy for primary colon cancer: results multicentre, open-label, phase 2 study. Lancet Oncol 2019;20:1070-1082.
from National Surgical Adjuvant Breast and Bowel Protocol C-03. J Clin Oncol 38 Mayer RJ, Van Cutsem E, Falcone A, et al. Randomized trial of TAS-102
1993;11:1879-1887. for refractory metastatic colorectal cancer (RECOURSE). N Engl J Med
27 Jäger E, Heike M, Bernhard H, et al. Weekly high-dose leucovorin versus low- 2015;372:1909-1919.
dose leucovorin combined with fluorouracil in advanced colorectal cancer: results 39 Pfeiffer PP, Yilmaz M, Moller S, et al. TAS-102 with or without bevacizumab
of a randomized multicenter trial. J Clin Oncol 1996;14:2274-2279. in patients with chemorefractory metastatic colorectal cancer: an investigator-
28 Van Cutsem E, Twelves C, Cassidy J, et al. Oral capecitabine compared with initiated, open-label, randomised, phase 2 trial. Lancet Oncol 2020;21:412-420.
intravenous fluorouracil plus leucovorin in patients with metastatic colorectal 40 Le DT, Uram JN, Wang H, et al. PD-1 blockade in tumors with mismatch-repair
cancer: results of a large phase III study. J Clin Oncol 2001;19:4097-4106. deficiency. N Engl J Med 2015;372:2509-2520.
29 Cunningham D, Lang I, Marcuello E, et al. Bevacizumab plus capecitabine 41 Overman MJ, McDermott R, Leach JL, et al. Nivolumab in patients with
versus capecitabine alone in elderly patients with previously untreated metastatic metastatic DNA mismatch repair deficient/microsatellite instability-high colorectal
colorectal cancer (AVEX): an open-label, randomised phase 3 trial. Lancet Oncol cancer (CheckMate 142): results of an open-label, multicentre, phase 2 study.
2013;14:1077-1085. Lancet Oncol 2017;18:1182-1191.
30 Cunningham D, Pyrhonen S, James R, et al. Randomised trial of irinotecan plus 42 Overman MJ, Lonardi S, Wong K, et al. Durable clinical benefit with nivolumab
supportive care versus supportive care alone after fluorouracil failure for patients plus ipilimumab in DNA mismatch repair–deficient/microsatellite instability–high
with metastatic colorectal cancer. The Lancet 1998;352:1413-1418. metastatic colorectal cancer. J Clin Oncol 2018;36:773-779.
Continued
Note: All recommendations are category 2A unless otherwise indicated.
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SYSTEMIC THERAPY FOR ADVANCED OR METASTATIC DISEASE – REFERENCES

43 Berton D, Banerjee SN, Curigliano G, et al. Antitumor activity of dostarlimab in patients with mismatch repair-deficient/microsatellite instability–high tumors: A
combined analysis of two cohorts in the GARNET study [abstract]. J Clin Oncol 2021;39(Suppl): Abstract 2564.
44 Meric-Bernstam F, Hurwitz H, Raghav KPS, et al. Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report
from a multicentre, open-label, phase 2a, multiple basket study. Lancet Oncol 2019;20:518-530.
45 Sartore-Bianchi A, Trusolino L, Martino C, et al. Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-
positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial. Lancet Oncol 2016;17:738-746.
46 Strickler JH, Cercek A, Siena S, et al. Additional analyses of MOUNTAINEER: A phase II study of tucatinib and trastuzumab for HER2-positive mCRC [abstract]. Ann
Oncol 2022;33:S808-S869.
47 Raghav KPS, Siena S, Takashima A,et al. Trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2-overexpressing/amplified (HER2+) metastatic colorectal
cancer (mCRC): Primary results from the multicenter, randomized, phase 2 DESTINY-CRC02 study. J Clin Oncol 2023;41:3501.
48 Van Cutsem E, Huijberts S, Grothey A, et al. Binimetinib, encorafenib, and cetuximab triplet therapy for patients with BRAF V600E-mutant metastatic colorectal
cancer: Safety lead-in results from the phase III BEACON colorectal cancer study. J Clin Oncol 2019;37:1460-1469.
49 Kopetz S, Grothey A, Yaeger R, et al. Encorafenib, binimetinib, and cetuximab in BRAF V600E-mutated colorectal cancer. N Engl J Med 2019;381:1632-1643.
50 Kopetz S, Grothey A, Van Cutsem E, et al. Quality of life with encorafenib plus cetuximab with or without binimetinib treatment in patients with BRAF V600E-mutant
metastatic colorectal cancer: patient-reported outcomes from BEACON CRC. ESMO Open 2022;7:100477.
51 Drilon A, Laetsch TW, Kummar S, et al. Efficacy of larotrectinib in TRK fusion-positive cancers in adults and children. N Engl J Med 2018;378:731-739.
52 Doebele RC, Drilon A, Paz-Ares L, et al. Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase
1-2 trials. Lancet Oncol 2020;21:271-282.
53 Solomon BJ, Drilon A, Lin JJ, et al. Repotrectinib in patients (pts) with NTRK fusion-positive (NTRK+) advanced solid tumors, including NSCLC: Update from the
phase I/II TRIDENT-1 trial. Annals of Oncology 2023;34:S755-S851.
54 Subbiah V, Wolf J, Konda B, et al. Tumour agnostic efficacy and safety of selpercatinib in patients with RET fusion-positive solid tumours other than lung or thyroid: a
global, phase 1/2, multicentre, open-label trial (LIBRETTO-001). Lancet Oncol 2022;23:1261-1273.
55 Yaeger R, Weiss J, Pelster M, et al. Adagrasib with or without cetuximab in colorectal cancer with mutated KRAS G12C. N Engl J Med 2023;388:44-54.
56 Kuboki Y, Yaeger R, Fakih MG, et al. Sotorasib in combination with panitumumab in refractory KRAS G12C-mutated colorectal cancer: Safety and efficacy for phase
Ib full expansion cohort. Ann Oncol 2022;33:S136-S196.
57 Dasari A , Lonardi S, Garcia-Carbonero R, et al. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international,
multicentre, randomised, double-blind, phase 3 study. Lancet 2023;402:41-53.

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PRINCIPLES OF SURVIVORSHIP – COLORECTAL LONG-TERM FOLLOW-UP CARE

Colorectal Cancer Surveillance • For oxaliplatin-induced neuropathy
• See REC-10. Consider duloxetine for painful neuropathy only, not effective for
• Long-term surveillance should be carefully managed with routine good numbness, tingling, or cold sensitivity.7
medical care and monitoring, including cancer screening, routine Refer to pain management specialist for refractory cases.
health care, and preventive care. Pregabalin or gabapentin are not recommended.
• Routine CEA monitoring and routine CT scanning are not recommended • Urogenital dysfunction after resection and/or pelvic radiation8,9
beyond 5 years. Screen for sexual dysfunction, erectile dysfunction, dyspareunia, and
vaginal dryness.
Survivorship Care Planning Screen for urinary incontinence, frequency, and urgency.
The oncologist and primary care provider should have defined roles in the Consider referral to urologist or gynecologist for persistent
surveillance period, with roles communicated to the patient.1 symptoms.
• Develop survivorship care plan that includes: • Potential for pelvic fractures/decreased bone density after pelvic
Overall summary of treatment, including all surgeries, radiation radiation
treatments, and chemotherapy received Consider bone density monitoring.
Description of possible expected time to resolution of acute toxicities,
long-term effects of treatment, and possible late sequelae of treatment Counseling Regarding Healthy Lifestyle and Wellness10
Surveillance recommendations (NCCN Guidelines for Survivorship)
Delineation of appropriate timing of transfer of care with specific • Undergo all age- and gender-appropriate cancer and preventive health
responsibilities identified for primary care physician and oncologist screenings as per national guidelines.
Health behavior recommendations • Maintain a healthy body weight throughout life.
Fertility counseling • Adopt a physically active lifestyle (at least 30 minutes of moderate-
intensity activity on most days of the week). Activity recommendations
Management of Late/Long-Term Sequelae of Disease or Treatment2-6 may require modification based on treatment sequelae (ie, ostomy,
• For issues related to distress, pain, neuropathy, fatigue, or sexual neuropathy).
dysfunction, see NCCN Guidelines for Survivorship. • Consume a healthy diet with an emphasis on plant sources. Diet
• Bowel function changes: chronic diarrhea, incontinence, stool recommendations may be modified based on severity of bowel
frequency, stool clustering, urgency, and cramping dysfunction.
Consider anti-diarrheal agents, bulk-forming agents, diet • Consider daily aspirin 325 mg for secondary prevention.
manipulation, pelvic floor rehabilitation, and protective • Drink alcohol sparingly, if at all.
undergarments. • Seek smoking cessation counseling as appropriate.
Management of an ostomy
◊ Consider participation in an ostomy support group or coordination Additional health monitoring and immunizations should be performed
of care with a health care provider specializing in ostomy care (ie, as indicated under the care of a primary care physician. Survivors are
ostomy nurse). encouraged to maintain a therapeutic relationship with a primary care
◊ Screen for distress around body changes (NCCN Guidelines for physician throughout their lifetime.
Distress Management) and precautions around involvement with
physical activity (SPA-A in the NCCN Guidelines for Survivorship).

References

Note: All recommendations are category 2A unless otherwise indicated.

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PRINCIPLES OF SURVIVORSHIP – COLORECTAL LONG-TERM FOLLOW-UP CARE

REFERENCES
1 Hewitt M, Greenfield S, Stovall E. From Cancer Patient to Cancer Survivor: Lost in Transition. Washington, D.C.:The National Academies Press; 2006.
2 Schneider EC, Malin JL, Kahn KL, et al. Surviving colorectal cancer. Cancer 2007;110: 2075-2082.
3 Sprangers MAG, Taal BG, Aaronson NK, et al. Quality of life in colorectal cancer: stoma vs. nonstoma patients. Dis Colon Rectum 1995;38:361-369.
4 Gami B, Harrington K, Blake P, et al. How patients manage gastrointestinal symptoms after pelvic radiotherapy. Aliment Pharmacol Ther 2003;18:987-994.
5 DeSnoo L, Faithfull S. A qualitative study of anterior resection syndrome: the experiences of cancer survivors who have undergone resection surgery. Eur J Cancer
Care 2006;15:244-251.
6 McGough C, Baldwin C, Frost C, Andreyev HJN. Role of nutritional intervention in patients treated with radiotherapy for pelvic malignancy. Br J Cancer 2004;90:2278-
2287.
7 Lavoie Smith EM, Pang H, Cirrincione C, et al. Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral
neuropathy. JAMA 2013;309:1359-1367.
8 Lange MM, Mass CP, Marijnen CAM, et al. Risk factors for sexual dysfunction after rectal cancer treatment. Eur J Cancer 2009;45:1578-1588.
9 Lange MM, Mass CP, Marijnen CAM, et al. Urinary dysfunction after rectal cancer treatment is mainly caused by surgery. Brit J Cancer 2008;95:1020-1028.
10 Kushi LH, Byers T, Doyle C, et al and The American Cancer Society 2006 Nutrition and Physical Activity Guidelines Advisory Committee. American Cancer Society
Guidelines on Nutrition and Physical Activity for cancer prevention: Reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin
2006;56:254-281.

Note: All recommendations are category 2A unless otherwise indicated.

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PRINCIPLES OF NONOPERATIVE MANAGEMENT

To provide nonoperative management (NOM) for patients with rectal cancer, the multidisciplinary team's diagnostic skills are crucial. They
must accurately assess clinical, radiologic, and pathologic findings, determining patient eligibility for NOM and closely monitoring progress.
The team's expertise extends to tracking treatment responses, identifying surgical needs promptly, and adjusting the management plan
as necessary. Additionally, the team should maintain a comprehensive understanding of the watchful waiting literature and surveillance
methodology, adeptly treating patients with complete or near-complete clinical responses and regularly monitoring for potential tumor
recurrence or progression. Given this, NOM is recommended only at centers with experienced multidisciplinary teams and for patients
committed to intensive surveillance.
Criteria for Complete Clinical Response Near Complete Response6,7
• High-definition flexible endoscopy1 • If the patient has had a near complete response and wishes to avoid
Pale smooth scar with or without telangiectasia surgery, then an additional 8 weeks of observation followed by
No ulceration, nodularity, or mucosal irregularities reassessment can be considered.
No stricture An nCR is defined by:
• DRE1 ◊ Smooth induration or superficial minor mucosal irregularity on
Smooth, flat scar DRE
No nodularity ◊ Endoscopic appearance with irregular small mucosal nodules,
• Diffusion-weighted MRI2 superficial ulceration, or mild persistent erythema
Fibrotic, linear scar with low signal intensity on T2-weighted ◊ T2-weighted MRI with downstaging with or without residual
images fibrosis, small area of residual signal, and complete or partial
No diffusion restriction regression of lymph nodes
No suspicious lymph nodes ◊ Diffusion-weighted MRI with small area of residual high signal
• All of the criteria must be satisfied in order to define a complete intensity
clinical response
• Biopsy offers no added diagnostic value if the criteria are met3,4 Indications for Surgery
• Circulating tumor DNA (ctDNA) has no proven role in the NOM of • Radical surgery is indicated for patients who do not ultimately
patients achieve a complete clinical response based on the above criteria or
patients who have tumor regrowth after a clinical response.
Timing of Assessment for Complete Clinical Response • If residual tumor or regrowth is suspected at the time of
• For patients treated with chemotherapy first followed by radiation assessment, it is not necessary to perform biopsies. False-negative
(induction chemotherapy), assessment should be performed no biopsies are common in this scenario and a high degree of
earlier than 8 weeks after completion of radiotherapy to allow time suspicion for tumor is sufficient as an indication for surgery.8
for delayed response to radiation.5
• For patients treated with radiation first followed by chemotherapy
(consolidation chemotherapy), assessment should be completed
within a month of completion of chemotherapy.

References
Note: All recommendations are category 2A unless otherwise indicated.
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PRINCIPLES OF NONOPERATIVE MANAGEMENT – REFERENCES

1 Habr-Gama A, Perez R, Proscurshim I, et al. Complete clinical response after neoadjuvant chemoradiation for distal rectal cancer. Surg Oncol Clin N Am 2010;19:829-
845.
2 Barbaro B, Fiorucci C, Tebala C, et al. Locally advanced rectal cancer: MR imaging in prediction of response after preoperative chemotherapy and radiation therapy.
Radiology 2009;250:730-9.
3 Maas M, Lambregts DMJ, Nelemans P, et al. Assessment of clinical complete response after chemoradiation for rectal cancer with digital rectal examination,
endoscopy, and MRI: Selection for organ-saving treatment. Ann Surg Oncol 2015;22:3873-3880.
4 Martens M, Maas M, Heijnen L, et al. Long-term outcome of an organ preservation program after neoadjuvant treatment for rectal cancer. J Natl Cancer Inst
2016;108:djw171.
5 Garcia-Aguilar J, Patil S, Gollub M, et al. Organ preservation in patients with rectal adenocarcinoma treated with total neoadjuvant therapy. J Clin Oncol 2022;40:2546-
2556.
6 Hupkens BJP, Maas M, Martens M, et al. Organ preservation in rectal cancer after chemoradiation: Should we extend the observation period in patients with a clinical
near-complete response? Ann Surg Oncol 2018;25:197-203.
7 Custers P, van der Sande M, Grotenhuis B, et al. Long-term quality of life and functional outcome of patients with rectal cancer following a watch-and-wait approach.
JAMA Surg 2023;158:e230146.
8 Fokas E, Appelt A, Glynne-Jones R, et al. International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in
patients with rectal cancer. Nat Rev Clin Oncol 2021;18:805-816.

Note: All recommendations are category 2A unless otherwise indicated.

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American Joint Committee on Cancer (AJCC) TNM Staging Classification for Rectal Cancer 8th ed., 2017
Table 1. Definitions for T, N, M N Regional Lymph Nodes
T Primary Tumor NX Regional lymph nodes cannot be assessed
TX Primary tumor cannot be assessed N0 No regional lymph node metastasis
T0 No evidence of primary tumor N1 One to three regional lymph nodes are positive (tumor in lymph
Tis Carcinoma in situ: intramucosal carcinoma (involvement of lamina nodes measuring ≥0.2 mm), or any number of tumor deposits are
propria with no extension through muscularis mucosae) present and all identifiable lymph nodes are negative
T1 Tumor invades the submucosa (through the muscularis mucosa N1a One regional lymph node is positive
but not into the muscularis propria) N1b Two or three regional lymph nodes are positive
T2 Tumor invades the muscularis propria N1c No regional lymph nodes are positive, but there are tumor
T3 Tumor invades through the muscularis propria into pericolorectal deposits in the subserosa, mesentery, or nonperitonealized
tissues pericolic, or perirectal/mesorectal tissues
T4 Tumor invades* the visceral peritoneum or invades or adheres** to N2 Four or more regional lymph nodes are positive
adjacent organ or structure N2a Four to six regional lymph nodes are positive
T4a Tumor invades* through the visceral peritoneum (including gross N2b Seven or more regional lymph nodes are positive
perforation of the bowel through tumor and continuous invasion of
tumor through areas of inflammation to the surface of the visceral
peritoneum) M Distant Metastasis
T4b Tumor directly invades* or adheres** to adjacent organs or M0 No distant metastasis by imaging, etc.; no evidence of tumor
structures in distant sites or organs. (This category is not assigned by
pathologists)
M1 Metastasis to one or more distant sites or organs or peritoneal
metastasis is identified
M1a Metastasis to one site or organ is identified without peritoneal
metastasis
M1b Metastasis to two or more sites or organs is identified without
peritoneal metastasis
M1c Metastasis to the peritoneal surface is identified alone or with
other site or organ metastases
* Direct invasion in T4 includes invasion of other organs or other segments of the colorectum as a result of direct extension through the serosa, as confirmed on
microscopic examination (for example, invasion of the sigmoid colon by a carcinoma of the cecum) or, for cancers in a retroperitoneal or subperitoneal location, direct
invasion of other organs or structures by virtue of extension beyond the muscularis propria (i.e., respectively, a tumor on the posterior wall of the descending colon
invading the left kidney or lateral abdominal wall; or a mid or distal rectal cancer with invasion of prostate, seminal vesicles, cervix, or vagina).
** Tumor that is adherent to other organs or structures, grossly, is classified cT4b. However, if no tumor is present in the adhesion, microscopically, the classification
should be pT1-4a depending on the anatomical depth of wall invasion. The V and L classification should be used to identify the presence or absence of vascular or
lymphatic invasion whereas the PN prognostic factor should be used for perineural invasion.
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition
(2017) published by Springer International Publishing.
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Rectal Cancer Discussion

American Joint Committee on Cancer (AJCC)

TNM Staging System for Rectal Cancer 8th ed., 2017
Table 2. Prognostic Groups
T N M
Stage 0 Tis N0 M0
Stage I T1, T2 N0 M0
Stage IIA T3 N0 M0
Stage IIB T4a N0 M0
Stage IIC T4b N0 M0
Stage IIIA T1-T2 N1/N1c M0
T1 N2a M0
Stage IIIB T3-T4a N1/N1c M0
T2-T3 N2a M0
T1-T2 N2b M0
Stage IIIC T4a N2a M0
T3-T4a N2b M0
T4b N1-N2 M0
Stage IVA Any T Any N M1a
Stage IVB Any T Any N M1b
Stage IVC Any T Any N M1c

Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition
(2017) published by Springer International Publishing.
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Rectal Cancer Discussion

ABBREVIATIONS

ASCO American Society of Clinical FAP familial adenomatous polyposis PCR polymerase chain reaction
Oncology FISH fluorescence in situ hybridization pMMR proficient mismatch repair
PNI perineural invasion
C/A/P chest/abdomen/pelvis
GBCA gadolinium-based contrast agent PPAP polymerase proofreading-
CAP College of American Pathologists associated polyposis
GFR glomerular filtration rate
CBC complete blood count PV pathogenic variant
GTV gross tumor volume
cCR clinical complete response
CEA carcinoembryonic antigen SBRT stereotactic body radiation therapy
H&E hematoxylin and eosin
CLIA Clinical Laboratory Improvement SNV single nucleotide variant
Amendments
CLIA-88 clinical laboratory improvement IGRT image-guided radiation therapy
TAMIS transanal minimally invasive surgery
amendments of 1988 IHC immunohistochemistry
TEM transanal endoscopic microsurgery
CRC colorectal cancer IMRT intensity-modulated radiation
therapy TMB tumor mutational burden
CRM circumferential resection margin
IORT intraoperative radiation therapy TMB-H tumor mutational burden-high
ctDNA circulating tumor DNA
TME total mesorectal excision
CTV clinical target volume
LS Lynch syndrome

DCE dynamic contrast-enhanced LST laterally spreading tumor

dMMR mismatch repair deficient

DRE digital rectal examination MMR mismatch repair

DWI diffusion-weighted imaging MRF mesorectal fascia

MSI microsatellite instability

EBRT external beam radiation therapy MSI-H microsatellite instability-high

ED exonuclease domain MSS microsatellite stable

EMVI extramural vascular invasion
ESD endoscopic submucosal dissection nCR near complete response
EUS endoscopic ultrasound NGS next-generation sequencing
NOM nonoperative management

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NCCN Categories of Evidence and Consensus

Category 1 Based upon high-level evidence (≥1 randomized phase 3 trials or high-quality, robust meta-analyses), there is
uniform NCCN consensus (≥85% support of the Panel) that the intervention is appropriate.
Category 2A Based upon lower-level evidence, there is uniform NCCN consensus (≥85% support of the Panel) that the
intervention is appropriate.
Category 2B Based upon lower-level evidence, there is NCCN consensus (≥50%, but <85% support of the Panel) that the
intervention is appropriate.
Category 3 Based upon any level of evidence, there is major NCCN disagreement that the intervention is appropriate.
All recommendations are category 2A unless otherwise indicated.

NCCN Categories of Preference

Interventions that are based on superior efficacy, safety, and evidence; and, when appropriate,
Preferred intervention affordability.
Other recommended Other interventions that may be somewhat less efficacious, more toxic, or based on less mature data;
intervention or significantly less affordable for similar outcomes.
Useful in certain
Other interventions that may be used for selected patient populations (defined with recommendation).
circumstances
All recommendations are considered appropriate.

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Discussion This discussion corresponds to the NCCN Guidelines Determining Resectability .......................................................... MS-37
f or Rectal Cancer. Last updated January 25, 2023
Neoadjuvant Therapy and Conversion to Resectability .............. MS-38
Table of Contents
Perioperative Therapy for Resectable Metachronous Metastatic
Overview......................................................................................... MS-2 Disease ..................................................................................... MS-42
Guidelines Update Methodology................................................... MS-2 Systemic Therapy for Advanced or Metastatic Disease ............. MS-43
Literature Search Criteria .............................................................. MS-2 Recommendations for Treatment of Resectable Synchronous
Sensitive/Inclusive Language Usage ............................................ MS-3 Metastases................................................................................ MS-44

Risk Assessment ........................................................................... MS-3 Recommendations for Treatment of Unresectable Synchronous

Metastases................................................................................ MS-45
Lynch Syndrome.......................................................................... MS-3
Recommendations for Treatment of Metachronous Metastases. MS-46
The Role of Vitamin D in CRC ..................................................... MS-4
Endpoints for Advanced CRC Clinical Trials ............................. MS-47
Other Risk Factors for CRC ......................................................... MS-5
Post-Treatment Surveillance....................................................... MS-47
TNM Staging ................................................................................... MS-6
Managing an Increasing CEA Level........................................... MS-50
Pathology ....................................................................................... MS-6
Treatment of Locally Recurrent Disease .................................... MS-50
Clinical Presentation and Treatment of Nonmetastatic Disease . MS-9
Survivorship................................................................................. MS-51
Management of Malignant Polyps ................................................ MS-9
Healthy Lifestyles for Survivors of CRC ..................................... MS-52
Management of Localized Rectal Cancer................................... MS-10
Secondary Chemoprevention for CRC Survivors ....................... MS-53
NCCN Recommendations for Nonmetastatic Rectal Cancer ...... MS-30
Summary ...................................................................................... MS-53
Management of Metastatic Disease ............................................ MS-32
Figure 1. Definition of Rectum .................................................... MS-55
Surgical Management of Colorectal Metastases ........................ MS-32
References ................................................................................... MS-56
Local Therapies for Metastases ................................................. MS-33

Peritoneal Carcinomatosis ......................................................... MS-37

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The authors estimate that the incidence rates for colon and rectal cancers
Overview will increase by 90.0% and 124.2%, respectively, for patients 20 to 34
Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer years by 2030. The cause of this trend is currently unknown. One review
and the second leading cause of cancer death in the United States. In suggests that CRC that occurs in young adult patients may be
2022, an estimated 44,850 new cases of rectal cancer will occur in the clinicopathologically and genetically different from CRC in older adults,
United States (26,650 cases in males; 18,200 cases in females). During although this has not been confirmed broadly. If cancer in this population
the same year, it is estimated that 52,580 people will die from rectal and is different, there would be a need to develop specific treatment strategies
colon cancer combined.1 Despite these high numbers, the incidence of for this population.5
colon and rectal cancers per 100,000 people decreased from 60.5 in 1976
to 46.4 in 2005 and, more recently, 38.7 in 2016.2,3 In addition, mortality This Discussion summarizes the NCCN Clinical Practice Guidelines in
from CRC has been decreasing for decades (since 1947 in females and Oncology (NCCN Guidelines®) Rectal Cancer. These guidelines begin with
since 1980 in males) and is currently down by more than 50% from peak the clinical presentation of the patient to the primary care physician or
mortality rates.1,3 These improvements in incidence of and mortality from gastroenterologist and address diagnosis, pathologic staging, surgical
CRC are thought to be a result of cancer prevention and earlier diagnoses management, perioperative treatment, management of recurrent and
through screening and of better treatment modalities. Recent data show metastatic disease, patient surveillance, and survivorship. These
continued rapid declines in incidence among those aged ≥65 years, with a guidelines overlap considerably with the NCCN Guidelines® for Colon
decrease of 3.3% annually between 2011 and 2016.3 CRC incidence and Cancer, especially in the treatment of metastatic disease. The
mortality rates vary by race and ethnicity with the highest rates in non- recommendations in these guidelines are classified as category 2A except
Hispanic Black individuals and lowest in Asian Americans/Pacific where noted. The panel unanimously endorses patient participation in a
Islanders.3 The magnitude of disparity in mortality rates is double that of clinical trial over standard or accepted therapy, especially for cases of
incidence rates. Reasons for these racial disparities include differences in advanced disease and for patients with locally aggressive CRC who are
risk factor prevalence, access to health care and other social determinants receiving combined modality treatment.
of health, comorbidities, and tumor characteristics.
Guidelines Update Methodology
Conversely, incidence has increased among those younger than 65 years, The complete details of the Development and Update of the NCCN
with a 1% annual increase in those aged 50 to 64 years and 2% annual Guidelines are available at www.NCCN.org.
increase in those younger than 50 years. CRC death rates also showed
age-dependent trends, declining by 3% annually for those ≥65 years of Literature Search Criteria
age, compared to a 0.6% annual decline for individuals aged 50 to 64 Prior to the update of the NCCN Guidelines for Rectal Cancer, an
years and a 1.3% annual increase for individuals younger than 50 years.3 electronic search of the PubMed database was performed to obtain key
A retrospective cohort study of the SEER CRC registry also found that the literature in colorectal cancer published since the previous Guidelines
incidence of CRC in patients younger than 50 years has been increasing.4 update, using the search terms: “colon cancer, colorectal cancer, rectal

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cancer.” The PubMed database was chosen because it remains the most future studies and organizations to use more inclusive and accurate
widely used resource for medical literature and indexes peer-reviewed language in their future analyses.
biomedical literature.6
Risk Assessment
The search results were narrowed by selecting studies in humans Approximately 20% of cases of CRC are associated with familial
published in English. Results were confined to the following article types: clustering, and first-degree relatives of patients with colorectal adenomas
Clinical Trial, Phase III; Clinical Trial, Phase IV; Guideline; Randomized or invasive CRC are at increased risk for CRC.7-11 Genetic susceptibility to
Controlled Trial; Meta-Analysis; Systematic Reviews; and Validation CRC includes well-defined inherited syndromes, such as Lynch syndrome
Studies. The data from key PubMed articles as well as articles from (also known as hereditary nonpolyposis CRC [HNPCC]) and familial
additional sources deemed as relevant to these guidelines as discussed adenomatous polyposis (FAP).12-14 Therefore, it is recommended that all
by the panel during the Guidelines update have been included in this patients with CRC be queried regarding their family history and considered
version of the Discussion section. Recommendations for which high-level for risk assessment, as detailed in the NCCN Guidelines for Colorectal
evidence is lacking are based on the panel’s review of lower-level Cancer Screening. Results from a randomized controlled trial (RCT)
evidence and expert opinion. suggest that most individuals without a personal history of CRC and with
one first-degree relative with CRC diagnosed before age 50 years or two
Sensitive/Inclusive Language Usage
first-degree relatives with CRC diagnosed at any age can safely be
NCCN Guidelines strive to use language that advances the goals of screened with colonoscopy every 6 years.15
equity, inclusion, and representation. NCCN Guidelines endeavor to use
language that is person-first; not stigmatizing; anti-racist, anti-classist, anti- CRC is a heterogeneous disease. An international consortium recently
misogynist, anti-ageist, anti-ableist, and anti-fat-biased; and inclusive of reported a molecular classification, defining four different subtypes: CMS1
individuals of all sexual orientations and gender identities. NCCN (MSI Immune), hypermutated, microsatellite unstable (see Lynch
Guidelines incorporate non-gendered language, instead focusing on Syndrome and Microsatellite Instability, below), with strong immune
organ-specific recommendations. This language is both more accurate activation; CMS2 (Canonical), epithelial, chromosomally unstable, with
and more inclusive and can help fully address the needs of individuals of marked WNT and MYC signaling activation; CMS3 (Metabolic), epithelial,
all sexual orientations and gender identities. NCCN Guidelines will with evident metabolic dysregulation; and CMS4 (Mesenchymal),
continue to use the terms men, women, female, and male when citing prominent transforming growth factor β activation, stromal invasion, and
statistics, recommendations, or data from organizations or sources that do angiogenesis.16 However, this classification is not yet recommended in
not use inclusive terms. Most studies do not report how sex and gender clinical practice.
data are collected and use these terms interchangeably or inconsistently.
If sources do not differentiate gender from sex assigned at birth or organs Lynch Syndrome
present, the information is presumed to predominantly represent cisgender Lynch syndrome is the most common form of genetically determined CRC
individuals. NCCN encourages researchers to collect more specific data in predisposition, accounting for 2% to 4% of all CRC cases.12,13,17,18 This

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hereditary syndrome results from germline mutations in DNA mismatch Association.28,29 The Cleveland Clinic recently reported on its experiences
repair (MMR) genes (MLH1, MSH2, MSH6, and PMS2). Although implementing such a screening approach.30
identifying a germline mutation in an MMR gene through sequencing is
definitive for Lynch syndrome, patients usually undergo selection by The NCCN Colon/Rectal Cancer Panel endorses universal MMR or MSI
considering family history and performing an initial test on tumor tissue testing of all patients with newly diagnosed colon or rectal cancer to
before sequencing. One of two different initial tests can be performed on identify individuals with Lynch syndrome. This testing is also relevant for
CRC specimens to identify individuals who might have Lynch syndrome: treatment selection in stage IV disease (see Systemic Therapy for
1) immunohistochemical analysis for MMR protein expression, which is Advanced or Metastatic Disease, below). An infrastructure needs to be in
often diminished because of mutation; or 2) analysis for microsatellite place to handle the screening results in either case. A more detailed
instability (MSI), which results from MMR deficiency and is detected as discussion is available in the NCCN Guidelines for Colorectal Cancer
changes in the length of repetitive DNA elements in tumor tissue caused Screening.
by the insertion or deletion of repeated units.19 Testing the BRAF gene for
The Role of Vitamin D in CRC
mutation is indicated when immunohistochemical analysis shows that
MLH1 expression is absent in the tumor. The presence of a BRAF Prospective studies have suggested that vitamin D deficiency may
mutation indicates that MLH1 expression is down-regulated through contribute to CRC incidence and/or that vitamin D supplementation may
somatic methylation of the promoter region of the gene and not through a decrease CRC risk.31-37 Furthermore, several prospective studies have
germline mutation.19 shown that low vitamin D levels are associated with increased mortality of
patients with CRC.38-41 In fact, a systematic review and meta-analysis of
Many NCCN Member Institutions and other comprehensive cancer centers five studies totaling 2330 patients with CRC compared the outcomes of
now perform immunohistochemistry and sometimes MSI testing on all patients in the highest and lowest categories of vitamin D levels and found
newly diagnosed colorectal and endometrial cancers regardless of family better overall survival (OS) (hazard ratio [HR], 0.71; 95% CI, 0.55–0.91)
history to determine which patients should have genetic testing for Lynch and disease-specific mortality (HR, 0.65; 95% CI, 0.49–0.86) in those with
syndrome.20-23 The cost-effectiveness of this approach, referred to as higher vitamin D levels.42 Another meta-analysis determined that the
universal or reflex testing, has been confirmed for CRC, and this approach relationship between vitamin D levels and mortality is linear.43
has been endorsed by the Evaluation of Genomic Applications in Practice
and Prevention (EGAPP) working group at the Centers for Disease Results of a recent randomized, double-blind, placebo-controlled trial,
Control and Prevention (CDC)24-26 and by the American Society for Clinical however, showed that supplementation with vitamin D and/or calcium had
Pathology (ASCP), College of American Pathologists (CAP), Association no effect on the recurrence of colorectal adenomas within 3 to 5 years
for Molecular Pathology (AMP), and ASCO in a guideline on molecular after removal of adenomas in 2259 participants.44 A later analysis of the
biomarkers for CRC.27 The U.S. Multi-Society Task Force on Colorectal same study reported that the effect of vitamin D supplementation on
Cancer also recommends universal genetic testing of tumors of all patients recurrence of advanced adenomas varied significantly based on the
with newly diagnosed CRC, as does the American Gastroenterological genotype of the vitamin D receptor, indicating that only individuals with

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specific vitamin D receptor alleles may benefit from vitamin D consumption, and healthy diet) had an HR for the development of CRC of
supplementation for prevention of advanced adenomas.45 0.63 (95% CI, 0.54–0.74) compared with those who adhered to less than
or equal to one of the factors.71 Other large studies support the conclusion
Furthermore, no study has yet definitively shown that vitamin D that adherence to healthy lifestyle factors can reduce the risk of CRC.72,73
supplementation improves outcomes in patients with CRC. Several studies
have reported that supplementation did not improve survival.46-48 In Some data suggest that consumption of dairy may lower risk for the
addition, while the randomized, double-blind, phase II SUNSHINE trial development of CRC.69,74,75 However, a recent systematic review and
reported a longer progression-free survival (PFS) for patients with meta-analysis of 15 cohort studies (>900,000 subjects; >5200 cases of
previously untreated metastatic CRC (mCRC) randomized to standard CRC) only found an association between risk for colon cancer in males
treatment plus high-dose vitamin D supplementation compared to those and the consumption of nonfermented milk.76 No association was seen for
randomized to standard treatment plus low-dose vitamin D rectal cancer in males or for colon or rectal cancer in females, and no
supplementation (13.0 vs. 11.0 months), this difference was not significant association was seen with consumption of solid cheese or fermented milk.
(HR, 0.64; 95% CI, 0–0.90; P = .02).49 There was also no significant Large cohort studies and meta-analyses suggest that other dietary factors
difference between high- and standard-dose vitamin D supplementation may also lower the risk for CRC, including the consumption of fish and
for overall response rate (ORR) or OS. In a 2010 report, the Institute of legumes.77-79 Furthermore, the use of aspirin or nonsteroidal anti-
Medicine (now known as the National Academy of Medicine) concluded inflammatory drugs (NSAIDs) may also decrease the risk for CRC,80-85
that data supporting a role for vitamin D were only conclusive in bone although evidence supporting this association is limited and variable.86
health, and not in cancer and other diseases.50 Citing this report and the The updated U.S. Preventive Services Task Force (USPSTF) guidance
lack of level 1 evidence, the panel does not currently recommend routine concluded that there was insufficient evidence that aspirin use reduces
screening for vitamin D deficiency or supplementation of vitamin D in CRC incidence and, therefore, recommends that the decision to initiate
patients with CRC. low-dose aspirin for primary prevention of cardiovascular disease in adults
aged 40 to 59 years with a 10-year cardiovascular disease risk greater
Other Risk Factors for CRC than or equal to 10% should be individualized as the net benefit of aspirin
It is well-recognized that individuals with inflammatory bowel disease (ie, use in this group is small.87
ulcerative colitis, Crohn’s disease) are at an increased risk for CRC.51-53
Other possible risk factors for the development of CRC include smoking, In addition, some data suggest that smoking, metabolic syndrome,
the consumption of red and processed meats, alcohol consumption, obesity, and red/processed meat consumption are associated with a poor
diabetes mellitus, low levels of physical activity, metabolic syndrome, and prognosis.60,88-92 Conversely, post-diagnosis fish consumption may be
obesity/high body mass index (BMI).52,54-70 In fact, in the European associated with a better prognosis.93 A family history of CRC increases
Prospective Investigation into Cancer and Nutrition (EPIC) cohort of risk while improving prognosis.94 Data on the effect of dairy consumption
almost 350,000 individuals, those who adhered to five healthy lifestyle on prognosis after diagnosis of CRC are conflicting.95,96
factors (healthy weight, physical activity, non-smoking, limited alcohol

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The relationship between diabetes and CRC is complex. Whereas mesentery, or non-peritonealized pericolic or perirectal tissues without
diabetes and insulin use may increase the risk of developing CRC, regional nodal metastasis (ie, satellite tumor nodules) have been classified
treatment with metformin appears to decrease risk, at least in females.97- as N1c. Within each T stage, survival is inversely correlated with N stage
106 Results of a small randomized study suggest that 1 year of low-dose (N0, N1a, N1b, N2a, and N2b).114
metformin in patients who are non-diabetic with previously resected
colorectal adenomas or polyps may reduce the likelihood of subsequent In rectal cancer, T stage has more prognostic value than N stage: patients
adenomas or polyps.107 In addition, although patients with CRC and with stage IIIA disease (T1–2) have longer rectal cancer-specific survival
diabetes appear to have a worse prognosis than those without than patients with stage IIA (T3), IIB (T4a), and IIC (T4b) rectal cancer.115
diabetes,108,109 patients with CRC and diabetes treated with metformin
Metastatic disease is classified as M1a when metastases are to only one
seem to have a survival benefit over those not treated with
site/solid organ (including to lymph nodes outside the primary tumor
metformin.103,110,111 The data regarding the effects of metformin on CRC
regional drainage area). M1b is used for metastases to multiple distant
incidence and mortality, however, are not completely consistent, with
sites or solid organs, exclusive of peritoneal carcinomatosis. The 8th
some studies seeing no effect.112,113
edition of the AJCC Cancer Staging Manual includes the M1c category for
TNM Staging peritoneal carcinomatosis with or without blood-borne metastasis to
visceral organs.114 Patients with peritoneal metastases have a shorter PFS
The NCCN Guidelines for Rectal Cancer adhere to the current TNM
and OS than those without peritoneal involvement.116
(tumor, node, metastases) staging system of the American Joint
Committee on Cancer (AJCC) Cancer Staging Manual (Table 1 of the The prefixes “p” and “yp” used in TNM staging denote pathologic staging
guidelines).114 The TNM categories reflect very similar survival outcomes and pathologic staging following neoadjuvant therapy, respectively.114
for rectal and colon cancer; these diseases therefore share the same
staging system. Pathology
Pathologic staging information is provided by examination of the surgical
In the 8th edition of the AJCC Cancer Staging Manual, T1 tumors involve
specimen. Some of the information that should be detailed in the report of
the submucosa; T2 tumors penetrate through the submucosa into the
the pathologic evaluation of rectal cancer includes: 1) gross description of
muscularis propria; T3 tumors penetrate through the muscularis propria;
the tumor and specimen; 2) grade of the cancer; 3) depth of penetration
T4a tumors directly penetrate to the surface of the visceral peritoneum;
and extension to adjacent structures (T); 4) number of regional lymph
and T4b tumors directly invade or are adherent to other organs or
nodes evaluated; 5) number of positive regional lymph nodes (N); 6) the
structures.114
presence of distant metastases to other organs or sites including non-
Regional lymph node classification includes N1a (1 positive lymph node); regional lymph nodes (M); 7) the status of proximal, distal, circumferential
N1b (2–3 positive lymph nodes), N2a (4–6 positive nodes); and N2b (7 or (radial), and mesenteric margins117-121; 8) neoadjuvant treatment
more positive nodes). In addition, tumor deposit(s) in the subserosa, effect122,123; 9) lymphovascular invasion (LVI)124; 10) perineural invasion
(PNI)125-127; and 11) the number of tumor deposits.128-132
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Margins when postoperative treatment decisions are made. Furthermore, in a

The 8th edition of the AJCC Cancer Staging Manual includes the retrospective study of more than 17,000 patients with rectal cancer, CRM
suggestion that the surgeon mark the area of the specimen with the was found to be a better predictor of local recurrence for patients
deepest tumor penetration so that the pathologist can directly evaluate the undergoing surgery as initial therapy than for those who had received
status of the resection margins.114 preoperative therapy.120 CRM positivity based solely on intranodal tumor
should be noted as such; some studies have shown that positive
The circumferential margin or circumferential resection margin (CRM) is intranodal CRM is associated with lower recurrence rates than a positive
an important pathologic staging parameter in rectal cancer.133 The radial CRM by direct tumor extension. Additional components of the pathologic
margin for resected segments of the colon that are completely encased by evaluation of the surgical specimen following a total mesorectal excision
a peritonealized (serosal) surface is also referred to as the peritoneal (TME) are described under Surgical Approaches, below.
margin. The CRM is very important in segments of the colon or rectum
that are either not encased or only partially encased in peritoneum.133 The Lymph Nodes
CRM is the closest radial margin between the deepest penetration of the The AJCC and CAP recommend evaluation of 12 lymph nodes to
tumor and the edge of resected soft tissue around the rectum (ie, the accurately identify early-stage CRCs.114,133,141 The number of lymph nodes
retroperitoneal or subperitoneal aspect of the tumor) or from the edge of a that can be retrieved varies with age and gender of the patient and on
lymph node and should be measured in millimeters. Identification of the tumor grade or site.142 The literature lacks consensus regarding the
CRM is determined through evaluation of the outer circumference of the minimal number of lymph nodes needed to accurately identify early-stage
rectal and mesorectal specimen that often requires inking of the outer rectal cancer.143 Most of these studies have combined rectal and colon
surfaces and “bread-loaf” slicing of the specimen.134 The panel defines an cancers with surgery as the initial treatment. Two studies confined only to
involved or threatened CRM as tumor within 1 mm from the resected rectal cancer have reported 14 and greater than 10 lymph nodes as the
margin.119,121,135,136 This definition differs slightly from the minimal number to accurately identify stage II rectal cancer.144,145 A more
recommendations of the 2016 European Society of Gastrointestinal and recent analysis of patients with stage I or II rectal cancer in the SEER
Abdominal Radiology (ESGAR) consensus meeting in that ESGAR database found that OS improved with greater numbers of lymph nodes
defined the mesorectal fascia as “involved” when the distance between the retrieved.146 Furthermore, the mean number of lymph nodes retrieved from
mesorectal fascia and the tumor is less than or equal to 1 mm, while in rectal cancers treated with neoadjuvant therapy is significantly less than
their template, “threatened/involved” is listed as less than or equal to 2 those treated by surgery alone (13 vs. 19, P < .05; 7 vs. 10, P ≤ .0001).147-
mm.137 149 In fact, retrieval of fewer lymph nodes may be a marker of a higher

tumor response and better prognosis following neoadjuvant treatment.150-

Accurate pathologic assessment of the CRM of resected rectal tumor 152

specimens is crucial, because the CRM has been shown to be a strong

predictor of both local recurrence and OS,133,135,138,139 including in patients Results of studies evaluating the sentinel node for micrometastatic
undergoing neoadjuvant therapy,120,140 and is an important consideration disease through use of hematoxylin and eosin (H&E) staining to identify

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small foci of tumor cells and the identification of particular tumor antigens Response to Treatment
through immunohistochemical analysis have been reported.153,154 Although The most recent CAP Guidelines require that the pathology report
results of some of these studies seem promising, there is no uniformity in comment on treatment effects of neoadjuvant therapy.162 The tumor
the definition of “true” clinically relevant metastatic carcinoma. Some response should be graded on a scale of 0 (complete response – no
studies have considered detection of single cells by immunohistochemistry viable cancer cells observed) to 3 (poor response – minimal or no tumor
or by H&E, so-called isolated tumor cells (ITCs), to be kill; extensive residual cancer).122,123,162,163
micrometastasis.154,155 In addition, results of one study demonstrated that,
following neoadjuvant radiotherapy for rectal cancer, the sensitivity for the Perineural Invasion
sentinel node procedure was only 40%.156 Furthermore, in a recent study Several studies have demonstrated that the presence of PNI is associated
involving 156 patients with colon cancer and 44 patients with rectal with a significantly worse prognosis.125-127,164-166 For example, one
cancer, this “ultrastaging” of lymph nodes only changed the staging for 1% retrospective analysis of 269 consecutive patients who had colorectal
of patients.157 Others have noted that micrometastasis found in node- tumors resected at one institution found a 4-fold greater 5-year survival in
negative patients did not predict outcome.158 In contrast, a recent meta- patients without PNI versus patients whose tumors invaded nearby neural
analysis found that the presence of micrometastases increases the structures.126 Multivariate analysis of patients with stage II rectal cancer
likelihood of disease recurrence, whereas the presence of ITCs does showed that patients with PNI have a significantly worse 5-year disease-
not.159 free survival (DFS) compared to those without PNI (29% vs. 82%; P =
.0005).127 Similar results were seen for patients with stage III disease.125 A
There is also potential benefit of assessing regional lymph nodes for ITCs.
meta-analysis that included 58 studies and 22,900 patients also found that
One study of 312 consecutive patients with pN0 disease found that
PNI is associated with a worse 5-year OS (relative risk [RR], 2.09; 95% CI,
positive cytokeratin staining was associated with a higher risk of
1.68–2.61) and 5-year DFS (RR, 2.35; 95% CI, 1.66–3.31).165 PNI is
recurrence.160 Relapse occurred in 14% of patients with positive nodes
therefore included as a high-risk factor for systemic recurrence.
compared to 4.7% of those with negative nodes (HR, 3.00; 95% CI, 1.23–
7.32; P = .013). A recent systematic review and meta-analysis reached a Tumor Deposits
similar conclusion, finding decreased survival in patients with pN0 disease
Tumor deposits, or satellite nodules, are irregular discrete tumor deposits
with immunohistochemical or reverse transcriptase polymerase chain
in the perirectal fat that are away from the leading edge of the tumor and
reaction (RT-PCR) evidence of tumor cells in regional nodes.161 The 8th
show no evidence of residual lymph node tissue, but that are within the
edition of the AJCC Cancer Staging Manual notes that micrometastases
lymphatic drainage of the primary tumor. They are not counted as lymph
have been defined as clusters of 10 to 20 tumor cells or clumps of tumor
nodes replaced by tumor. Most of these tumor deposits are thought to be
greater than or equal to 0.2 mm in diameter and recommends that these
due to LVI or occasionally PNI. The number of tumor deposits should be
micrometastases be considered as standard positive nodes.114
recorded in the pathology report, since they have been shown to be
associated with reductions in DFS and OS.128-132,166 Multivariate survival
analysis in one study showed that patients with pN0 tumors without
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satellite nodules had a 91.5% 5-year survival rate compared to 37.0% for chemotherapy. For these patients, 5-year DSS was 98% for low-tier tumor
patients with pN0 tumors and the presence of satellite nodules (P < budding versus 80% for high-tier (P = .008). Tumor budding is therefore
.0001).132 Another retrospective study found a similar difference in 5-year included as a high-risk factor for recurrence and may inform decisions
OS rates (80.3% vs. 34.9%, respectively; P < .001).167 The association of related to adjuvant therapy.
tumor deposits with decreased survival also holds in patients with rectal
cancer who had neoadjuvant chemoradiation (chemoRT).168-170 Tumor Clinical Presentation and Treatment of Nonmetastatic
deposits are classified as pN1c.114 Disease
Management of Malignant Polyps
Tumor Budding
A malignant rectal polyp is defined as an adenoma that harbors a focus of
Tumor budding is defined as the presence of a single cell or a cluster of cancer invading through the muscularis mucosae and into the submucosa
four or fewer neoplastic cells as detected by H&E staining at the (pT1).179 Conversely, polyps classified as carcinoma in situ (pTis) have not
advancing edge of an invasive carcinoma. As specified by the 2016 penetrated into the submucosa and are therefore incapable of regional
International Tumor Budding Consensus Conference (ITBCC), the total nodal metastasis.133 Before making a decision about formal surgical
number of buds should be reported from a selected hot spot measuring resection for an endoscopically resected pedunculated or sessile
0.785 mm2.171 Budding is separated into three tiers: low (0–4 buds), malignant polyp, physicians should review the pathology180 and consult
intermediate (5–9 buds), and high (≥10 buds). with the patient. The panel recommends marking the malignant polyp site
at the time of colonoscopy or within 2 weeks if deemed necessary by the
Several studies have shown that high-grade tumor budding in pT1
surgeon. All patients with a malignant polyp should undergo MMR or MSI
colorectal cancer or malignant polyps is associated with an increased risk
testing at diagnosis.
of lymph node metastasis, although the methodologies for assessing
tumor budding were not uniform.172-176 Studies have also supported tumor In patients with pedunculated polyps (adenomas), no additional surgery is
budding as an independent prognostic factor for stage II colon cancer. A required if the polyp has been completely removed endoscopically with
retrospective study that assessed tumor budding in 135 stage II colon favorable histologic features.180,181 Favorable histologic features include
cancer specimens according to ITBCC criteria found that tumor budding lesions of grade 1 or 2 without angiolymphatic invasion and with a negative
correlated with survival outcomes.177 Disease-specific survival (DSS) was resection margin.180 There is controversy as to whether malignant
89% for low-tier tumor budding, 73% for intermediate-tier, and 52% for colorectal polyps with a sessile configuration can be successfully treated
high-tier (P = .001). Another retrospective study evaluated 174 stage II by endoscopic removal. The literature seems to indicate that
colon cancer specimens for tumor budding.178 This study also used the endoscopically removed sessile malignant polyps have a significantly
ITBCC criteria and found tumor budding to be independently associated greater incidence of adverse outcomes (residual disease, recurrent
with DSS (P = .01); specifically, 5-year DSS was 96% for low-tier tumor disease, mortality, and hematogenous metastasis, but not lymph node
budding compared to 92% for high-tier for all patients. The difference was metastasis) than do pedunculated malignant polyps. However, when one
even more dramatic for those patients who received no adjuvant closely looks at the data, configuration by itself is not a significant variable

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NCCN Guidelines Version 4.2024

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for adverse outcome, and endoscopically removed malignant sessile Management of Localized Rectal Cancer
polyps with grade I or II histology, negative margins, and no Rectal cancer is a cancerous lesion in the rectum, which lies below a
lymphovascular invasion can be successfully treated with endoscopic virtual line from the sacral promontory to the upper edge of the symphysis
polypectomy alone. Also see the section on Endoscopically Removed as determined by MRI (see Figure 1). The rectum ends at the superior
Malignant Polyps in Principles of Pathologic Review in the algorithm. border of the functional anal canal, defined as the palpable upper border
Rectal surgery is also an option for these patients. of the anal sphincter and puborectalis muscles of the anorectal ring.

Rectal surgery is also recommended for patients with malignant polyps The determination of an optimal treatment plan for an individual patient
with unfavorable histologic features or when the specimen is fragmented with rectal cancer is a complex process. In addition to decisions relating to
or margins cannot be assessed. A complete workup is recommended prior the intent of rectal cancer surgery (ie, curative or palliative), consideration
to surgery for patients with malignant polyps showing these characteristics must also be given to the likely functional results of treatment, including
since more extensive disease is more likely in this situation (see section the probability of maintaining or restoring normal bowel function/anal
on Clinical Evaluation/Staging under Management of Localized Rectal continence and preserving genitourinary functions. For patients with distal
Cancer). Unfavorable histologic features for adenomas are grade 3 or 4, rectal cancer, in particular, the simultaneous achievement of the goals of
angiolymphatic invasion, or a positive/unassessable margin of resection. cure and of minimal impact on quality of life can be challenging.189
In such cases, risk of nodal involvement is higher. It should be noted that Furthermore, the risk of pelvic recurrence is higher in patients with rectal
no consensus currently exists as to the definition of what constitutes a cancer compared to those with colon cancer, and locally recurrent rectal
positive margin of resection. A positive margin for an endoscopically cancer is associated with a poor prognosis.190-192 Careful patient selection
removed polyp has been defined as the presence of tumor within 1 to 2 with respect to particular treatment options and the use of sequenced
mm from the transected margin or by the presence of tumor cells within multimodality therapy that combines chemoRT, chemotherapy, and
the diathermy of the transected margin.180,182-184 In addition, several operative treatment for most patients is recommended.193
studies have shown that tumor budding is an adverse histologic feature
associated with adverse outcome and may preclude polypectomy as an Clinical Evaluation/Staging
adequate treatment of endoscopically removed malignant polyps.185-188 The initial clinical workup of patients with rectal cancer provides important
preoperative information on the clinical stage of disease. Since the clinical
Rectal surgery consists of either a transanal local excision, if appropriate, stage is used to direct decisions regarding choice of primary treatment,
or a transabdominal resection. In patients with unfavorable pathologic including surgical intent (eg, curative or palliative) and whether to
features, transabdominal resection should be considered in order to recommend total neoadjuvant therapy (TNT), the implications of either
include lymphadenectomy. All patients who have malignant polyps clinically understaging or overstaging rectal cancer can be substantial.
removed by transanal local excision or transabdominal resection should Based on this, a multidisciplinary team evaluation is recommended,
undergo total colonoscopy to rule out other synchronous polyps and including a formal surgical evaluation. A discussion of infertility risks and
should undergo surveillance as described in the guidelines.

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NCCN Guidelines Version 4.2024

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counseling on fertility preservation, if appropriate, should be carried out Preoperative Pelvic Imaging in Rectal Cancer
prior to the start of treatment. The accessibility of rectal cancer to evaluation by pelvic MRI with contrast
makes possible preoperative assessments of depth of tumor penetration
Patients who present with rectal cancer appropriate for resection require a and the presence of local lymph nodal metastases.194,195 Pelvic MRI has
complete staging evaluation, which includes total colonoscopy to evaluate the ability to provide accurate images of soft tissue structures in the
for synchronous lesions or other pathologic conditions of the colon and mesorectum, including the mesorectal fascia, so as to provide information
rectum. Proctoscopy can be useful in determining the distance of the useful in the prediction of the circumferential resection margin (CRM) prior
cancer from the anal verge and length and, therefore, is a consideration. to radical surgery.196-201 The CRM by MRI is measured at the closest
Patients with rectal cancer also require a complete physical examination,
distance of the tumor to the mesorectal fascia. The panel defines a clear
including carcinoembryonic antigen (CEA) determination and assessment
CRM as greater than 1 mm from mesorectal fascia and levator muscles
of performance status to determine operative risk.
and not invading into the intersphincteric plane. An involved or threatened
Clinical staging is also based on histopathologic examination of the CRM, in contrast, is within 1 mm of mesorectal fascia; or, for lower third
specimen obtained via biopsy or local excision (eg, excised polyps). rectal tumors, within 1 mm from levator muscle.136 Published 5-year follow-
Endoscopic biopsy specimens of the lesion should undergo careful up results of the MERCURY trial show that high-resolution MRI can
pathology review for evidence of invasion into the muscularis mucosa. If accurately assess the CRM preoperatively, differentiating patients with
removal of the rectum is contemplated, early consultation with an low- and high-risk disease.202 Patients with MRI-clear CRM had a 5-year
enterostomal therapist is recommended for preoperative marking of the OS of 62.2% compared with 42.2% in patients with MRI-involved CRM
site and patient teaching purposes. All patients with rectal cancer should (HR, 1.97; 95% CI, 1.27–3.04; P < .01). The preoperative MRI imaging
undergo MMR or MSI testing at diagnosis to aid in the diagnosis of Lynch also predicted DFS (HR, 1.65; 95% CI, 1.01–2.69; P < .05) and local
syndrome and for clinical trial availability, especially related to checkpoint recurrence (HR, 3.50; 95% CI, 1.53–8.00; P < .05). MRI has also been
inhibitors as neoadjuvant therapy (see section on dostarlimab-gxly in shown to be accurate for the prediction of T and N stage.203 ESGAR has
Preoperative Systemic Therapy Without Chemoradiation, below). Those developed consensus guidelines for standardized imaging of rectal cancer
with loss of MMR proteins and/or MSI should be referred for genetic by MRI.137
counseling and testing.
Only a limited number of studies using CT for the purpose of T-staging
Imaging also plays a critical role in preoperative evaluation, for evaluation have been performed, and it is not currently considered to be an optimal
of the primary tumor, regional adenopathy, and to assess for the presence method for staging the extent of tumor penetration.196,199,204 In addition, CT
of distant metastases. Preoperative imaging for rectal cancer includes has poor sensitivity for the prediction of CRM status.205 Furthermore, CT
chest/abdominal CT and pelvic MRI or chest CT and abdominal/pelvic has lower sensitivity and specificity for the prediction of lymph node
MRI, as described below. involvement than MRI (CT, 55% and 74%; MRI, 66% and 76%).204
Therefore, pelvic CT is not recommended for rectal staging.

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A 2004 meta-analysis showed that endoscopic ultrasound (EUS) and MRI Approach for Clinical Complete Responders and Preoperative Systemic
have similar sensitivities and specificities for evaluation of lymph nodes Therapy Without Chemoradiation, below). MRI, CT, and EUS have been
(EUS, 67% and 78%; MRI, 66% and 76%).204 However, newer data used for restaging after neoadjuvant treatment, but the accuracy of these
suggest that EUS is not very accurate for rectal cancer staging.206 techniques for determining T stage and lymph node involvement is
Furthermore, EUS cannot fully image high or bulky rectal tumors nor limited.212-220 As with initial staging, the panel recommends pelvic MRI for
regions beyond the immediate area of the primary tumor (eg, tumor restaging with chest and abdominal imaging to assess for distant disease.
deposits, vascular invasion).196 Another disadvantage of EUS is a high Abdominal/pelvic CT has been shown to identify resectable liver
degree of operator dependence.204 At this time, the panel recommends metastases in 2.2% (95% CI, 0.8%–5.1%) of patients during restaging,
that EUS may be used to evaluate the pelvis if MRI is contraindicated (eg, with false-positive findings that could cause unnecessary treatment in
because of a pacemaker), or it may be considered as an alternative for 1.3% (95% CI, 0.3%–3.9%) of patients.221 In this study, the use of
superficial lesions. restaging abdominal/pelvic CT was at the physician’s discretion, and no
difference was seen in relapse-free survival (RFS) for those who had an
Preoperative Imaging for Distant Metastases abdominal/pelvic CT before resection compared with those who did not.
Additional information regarding the occurrence of distant metastases
should be determined preoperatively through chest and abdominal Advanced functional MRI techniques (eg, dynamic contrast-enhanced
imaging. Chest imaging should be by CT scan, whereas imaging of the MRI, diffusion-weighted MRI) allow for the measurement of
abdomen can be performed with CT or MRI. Lung metastases occur in microcirculation, vascular permeability, and tissue cellularity and thus may
approximately 4% to 9% of patients with colon and rectal cancer,207-209 and be useful for determining response to neoadjuvant treatment and
studies have shown that 20% to 34% of patients with CRC present with restaging patients with rectal cancer.219,222-224 FDG PET/CT is also being
synchronous liver metastases.210,211 investigated for its ability to accurately determine response to neoadjuvant
treatment.223,225
The consensus of the panel is that a PET scan is not indicated for
preoperative staging of rectal cancer. PET/CT, if done, does not supplant At this time, the panel recommends chest CT, abdominal CT or MRI, and
a contrast-enhanced diagnostic CT scan. PET/CT should only be used to pelvic MRI for restaging.
evaluate an equivocal finding on a contrast-enhanced CT scan or in
Surgical Approaches
patients with a strong contraindication to IV contrast.
A variety of surgical approaches, depending on the location and extent of
Restaging/Assessing Treatment Response disease, are used to treat primary rectal cancer lesions.226,227 These
Restaging after neoadjuvant treatment is done to detect distant methods include local procedures, such as polypectomy, transanal local
metastases that would change the treatment strategy, to plan the surgical excision, and transanal endoscopic microsurgery (TEM), and more
approach, and, increasingly, to determine if additional therapy or resection invasive procedures involving a transabdominal resection (eg, low anterior
can be avoided for select patients (see Watch-and-Wait Nonoperative resection [LAR], proctectomy with TME and coloanal anastomosis,
abdominoperineal resection [APR]).226,227

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Transanal Local Excision tumors.233 A meta-analysis reported a substantial risk of local recurrence
Transanal local excision is only appropriate for selected T1, N0 early- in patients with high-risk pT1 and pT2 rectal cancer who receive no
stage cancers. Small (<3 cm), well to moderately differentiated tumors that additional therapy following local excision.234 Completion TME or adjuvant
are within 8 cm of the anal verge and limited to less than 30% of the rectal chemoRT (for pT1) were found to mitigate that risk. Results of a multi-
circumference and for which there is no evidence of nodal involvement institutional, single-arm, open-label, non-randomized, phase II trial suggest
can be approached with transanal local excision with negative margins.228 that chemoradiotherapy with CAPEOX followed by local excision may be a
In addition, full-thickness excision must be feasible. safe alternative to transabdominal resection in patients with T2N0 distal
rectal cancer.235 A meta-analysis also suggests that this approach of
TEM can facilitate excision of small tumors through the anus when lesions neoadjuvant chemoRT followed by local excision may be a safe and
can be adequately identified in the rectum. TEM may be technically effective alternative for patients with any T and any N stage of rectal
feasible for more proximal lesions. Although data are limited, a 2015 meta- cancer who refuse or are unfit for transabdominal resection.236 Further
analysis found that TEM may achieve superior oncologic outcomes studies in this area are needed.
compared with transanal local excision.229 A small prospective, single-
blind, randomized trial compared laparoscopic surgery with laparoscopy Advantages of a local procedure include minimal morbidity (eg, a
combined with TEM in 60 patients with rectal cancer.230 The TEM group sphincter-sparing procedure) and mortality and rapid postoperative
had shorter operation times and hospital stays, and no local nor distant recovery.189,233 Limitations of a local excision include the absence of
recurrences were seen in either group after a median follow-up of 28 pathologic staging of nodal involvement. Further, evidence indicates that
months. lymph node micrometastases are both common in early rectal lesions and
unlikely to be identified by endorectal ultrasound.237 These observations
Both transanal local excision and TEM involve a full-thickness excision may underlie the findings that patients undergoing local excision have a
performed perpendicularly through the bowel wall into the perirectal fat. higher local recurrence rate than those undergoing radical
Negative (>3 mm) deep and mucosal margins are required, and tumor resection.233,238,239 A retrospective study of 282 patients undergoing either
fragmentation should be avoided. transanal local excision or radical resection for T1 rectal cancer from 1985
to 2004 showed respective local recurrence rates of 13.2% and 2.7% for
The locally excised specimen should be oriented and pinned before
these two groups (P = .001).239 A similar retrospective study of 2124
fixation and brought to the pathologist by the surgeon to facilitate an
patients showed local recurrence rates of 12.5% and 6.9% for patients
oriented histopathologic evaluation of the specimen. If pathologic
undergoing local excision versus standard resection, respectively (P =
examination reveals adverse features such as positive margins, LVI, poor
.003).233 More recently, an analysis of greater than 164,000 individuals
differentiation, or invasion into the lower third of the submucosa (sm3
from the National Cancer Database (NCDB) with resected, invasive,
level),231,232 a more radical resection is recommended.
nonmetastatic rectal cancer diagnosed from 1998 to 2010 found that
Data are limited on long-term patient outcomes, including risk of local positive margins were more likely after local excision compared to
recurrence, for patients undergoing local excision for high-risk T1 or T2 transabdominal excision in both the T1 and T2 populations (95% vs. 76%

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NCCN Guidelines Version 4.2024

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in T1/T2 combined; P < .001).240 In the T1, N0 population, a small but dissection beyond the field of resection (eg, into the distribution of iliac
significant decrease in OS was also noted in the local excision group. lymph nodes) unless these nodes are clinically suspicious. In cases where
Interestingly, limited data suggest that TEM might have superior oncologic anal function is intact and distal clearance is adequate, the TME may be
outcomes in patients with stage I rectal cancer compared with radical followed by creation of a coloanal anastomosis.
resection,238,241 although not all studies have seen such results.242
For lesions in the mid to upper rectum, an LAR extended 4 to 5 cm below
Thus, careful patient selection for local excision of T1, N0 rectal cancer is the distal edge of the tumor using TME, followed by creation of a
important, as is the careful examination of the resection specimen with colorectal anastomosis, is the treatment of choice. Where creation of an
subsequent transabdominal resection in patients found to have T2 disease anastomosis is not possible, colostomy is required. Wide TME is
or high-risk features, as described above. recommended in order to facilitate adequate lymphadenectomy and
improve the probability of achieving negative circumferential margins.
Transabdominal Resection
Patients with rectal cancer who do not meet requirements for local surgery An APR with TME should be performed when the tumor directly involves
should be treated with a transabdominal resection. Organ-preserving the anal sphincter or the levator muscles. An APR is also necessary in
procedures that maintain sphincter function are preferable, but not cases where a margin-negative resection of the tumor would result in loss
possible in all cases. Preoperative chemoRT or TNT may result in tumor of anal sphincter function and incontinence. An APR involves en bloc
downsizing and a decrease in tumor bulk (see section on Neoadjuvant and resection of the rectosigmoid, the rectum, and the anus, as well as the
Adjuvant Therapy for Resectable Nonmetastatic Disease, below); surrounding mesentery, mesorectum (TME), and perianal soft tissue, and
sphincter preservation may become possible in cases where initial tumor it necessitates creation of a colostomy.246 In the NSABP R-04 trial,
bulk prevented consideration of such surgery and exposure to the tumor is patients who had an APR reported worse body image, worse micturition
improved by neoadjuvant treatment. symptoms, and less sexual enjoyment at 1-year post surgery than those
who had sphincter-sparing surgery.247 An extralevator APR may have
In transabdominal resections, TME is recommended. A TME involves an benefits over a conventional APR approach, including lower rates of
en bloc removal of the mesorectum, including associated vascular and intraoperative perforation, CRM involvement, and local recurrence,
lymphatic structures, fatty tissue, and mesorectal fascia as a “tumor although inconsistencies are seen between studies.248,249
package” through sharp dissection and is designed to spare the autonomic
nerves.189,227,243 The lymphatic drainage regions of rectal tumors are Pathologists play a key role in evaluating the surgical specimen, including
influenced by their position in the rectum. More distal tumors are more a macroscopic assessment of both its external appearance/completeness
likely to be characterized by both upward and lateral lymphatic drainage, and the CRM.250,251 The panel defines an involved or threatened CRM as
whereas the likelihood of only upward mesorectal drainage is much higher tumor within 1 mm from the resected margin (see Pathology,
for more proximal tumors.244 The TME approach is designed to radically above).119,121,135,136 Detailed descriptions of how the quality of the
remove lymphatic drainage regions of tumors located above the level of mesorectal specimens should be scored were provided in the Dutch
the levator muscles.245 The panel does not recommend extension of nodal
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Rectal Cancer Trial, and these guidelines are endorsed by the NCCN In the CLASICC trial comparing laparoscopically assisted resection to
Panel.119 open resection, nearly half of the 794 patients were diagnosed with rectal
cancer.262 No significant differences in local recurrence, DFS, or OS were
Recent retrospective comparisons of the outcomes of patients undergoing observed between the two groups of patients with colon or rectal cancer
an APR versus an LAR in the treatment of rectal cancer have shown that based on surgical approach. A 5-year follow-up of the CLASICC trial
those treated with an APR have worse local control and OS.252,253 Whether showed that this lack of difference in local recurrence, DFS, or OS was
these differences can be attributed to the surgical procedure alone, to maintained for patients with rectal cancer, despite a trend towards better
patient- and tumor-related characteristics, or some combination of these 5-year OS after laparoscopic surgery (52.9% and 60.3% for open and
factors is presently unclear. However, results from a recent retrospective laparoscopic surgery, respectively; P = .132).263
study of 3633 patients with T3–4 rectal cancer tumors included in five
large European trials suggest that there is an association between the The COREAN trial randomized patients with stage II or III low- to mid-
APR procedure itself and the increased risks of recurrence and death.252 rectal cancer to an open or laparoscopic resection, with short-term
Importantly, quality of life between patients with or without a permanent benefits seen with the laparoscopic approach.264 The primary endpoint, 3-
colostomy appears to be fairly comparable.254,255 year DFS, did not differ between the two groups at 72.5% (95% CI,
65.0%–78.6%) for open surgery and 79.2% (95% CI, 72.3%–84.6%) for
Laparoscopic Resection the laparoscopic group.257 Factors that may confound conclusions drawn
Data from randomized studies evaluating use of laparoscopic surgery in from randomized studies comparing open surgery to laparoscopically
the treatment of patients with rectal cancer have matured in recent assisted surgery for CRC have been described,265 and longer-term
years.256-259 One large prospective multicenter study, which included 4405 outcomes from laparoscopic rectal surgery have not been reported.
patients with rectal cancer but was not randomized, found no differences
in recurrence or survival, although complications and other measures of Two other trials, ACOSOG Z6051 and ALaCaRT, have reported
quality indicated a benefit to the laparoscopic approach.260 The phase III pathologic outcomes.258,259 In Z6051, the primary endpoint was a
COLOR II trial, powered for non-inferiority, randomized patients with composite of CRM greater than 1 mm, negative distal margin, and TME
localized rectal cancer to laparoscopic or open surgery. Short-term completeness.258 No significant differences were observed between the
secondary endpoints were met, with patients in the laparoscopic arm arms in these three measures or in the composite of successful resection.
losing less blood, having shorter hospital stays, and having a quicker For example, complete or nearly complete TME was achieved in 92.1%
return of bowel function, but with longer operation times.261 No differences (95% CI, 88.7%–95.5%) in the laparoscopic resection arm and 95.1%
were seen in completeness of resection, percentage of patients with a (95% CI, 92.2%–97.9%) in the open resection arm, for a difference of −3.0
positive CRM, morbidity, or mortality between the arms. The primary (95% CI, -7.4 to 1.5; P = .20). However, the criteria for non-inferiority of
endpoint of locoregional recurrence at 3 years was identical in the two the laparoscopic approach were not met in these initial results. Follow-up
groups, at 5.0%, and no statistically significant differences were seen in results of Z6051 reported similar 2-year DFS rates between laparoscopic
DFS or OS.256 (79.5%) and open resection (83.2%).266 Locoregional and distant

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recurrence rates were also found to be similar between laparoscopic and surgery,256,257 whereas other studies have shown the laparoscopic
open resection (4.6% vs. 4.5% for locoregional recurrences and 14.6% vs. approach to be associated with higher rates of CRM positivity and
16.7% for distant recurrences). In ALaCaRT, the primary endpoint was incomplete TME.258,259 The panel defined principles by which minimally
also a composite of resection quality measures.259 Successful resections invasive resection of rectal cancer can be considered: the procedure can
were achieved in 82% of the laparoscopic resection arm and 89% of the be considered by an experienced surgeon, should include thorough
open resection arm, for a difference of -7.0% (95% CI, -12.4% to infinity). abdominal exploration, and should be limited to lower-risk tumors, as
A negative CRM was achieved in 93% and 97%, respectively (risk outlined in the guidelines. An international group of experts has defined
difference, -3.7%; 95% CI, -7.6% to 0.1%; P = .06). Follow-up results for standards for the technical details of laparoscopic TME.289
ALaCaRT showed similar recurrence, DFS, and OS rates for laparoscopic
versus open resection after 2 years.267 Two-year locoregional recurrence Neoadjuvant and Adjuvant Therapy for Resectable Nonmetastatic Disease
rates were 5.4% and 3.1%, 2-year DFS rates were 80% and 82%, and 2- Neoadjuvant/adjuvant therapy for stage II (T3–4, node-negative disease
year OS rates were 94% and 93% for laparoscopic resection and open with tumor penetration through the muscle wall) or stage III (node-positive
resection, respectively. As in Z6051, the criteria for non-inferiority of the disease without distant metastasis) rectal cancer usually includes
laparoscopic approach were not met in the initial ALaCaRT report, but the locoregional treatment due to the relatively high risk of locoregional
techniques were found to not differ significantly after longer follow-up with recurrence. This risk is associated with the close proximity of the rectum to
oncologic outcomes. pelvic structures and organs, the absence of a serosa surrounding the
rectum, and technical difficulties associated with obtaining wide surgical
An analysis of results from greater than 18,000 individuals in the NCDB margins at resection. In contrast, adjuvant treatment of colon cancer is
undergoing LAR for rectal cancer found short-term oncologic outcomes to more focused on preventing distant metastases since this disease is
be similar between the open and laparoscopic approaches.268 In addition, characterized by lower rates of local recurrence.
older reviews and meta-analyses consistently found the laparoscopic
approach to be safe and feasible,257,269-282 even though a meta-analysis Although radiation therapy (RT) has been associated with decreased rates
published in 2017 found that the risk for a non-complete mesorectal of local recurrence of rectal cancer, it is also associated with increased
excision is significantly higher in patients receiving a laparoscopic toxicity (eg, radiation-induced injury, hematologic toxicities) relative to
resection compared with those receiving an open resection.283 Several surgery alone.134,290,291 It has been suggested that some patients with
studies have also compared outcomes of robotic-assisted resection to disease at lower risk of local recurrence (eg, proximal rectal cancer staged
conventional laparoscopic resection.284-288 Comparable results are as T3, N0, M0, characterized by clear margins and favorable prognostic
generally seen between the approaches in conversion to open resection, features) may be adequately treated with surgery and adjuvant
TME quality, postoperative complications, and quality of life. chemotherapy.134,292,293 However, 22% of 188 patients clinically staged
with T3, N0 rectal cancer by either EUS or MRI who subsequently
In conclusion, some studies have shown that laparoscopy is associated received preoperative chemoRT had positive lymph nodes following
with similar short- and long-term outcomes when compared to open pathologic review of the surgical specimens according to results of a

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retrospective multicenter study,294 suggesting that many patients are rates in patients with stage II–III rectal cancer treated with chemoRT alone
under-staged and would benefit from chemoRT. Therefore, the guidelines or chemoRT followed by increasing durations of FOLFOX prior to
recommend preoperative treatment for patients with T3, N0 disease. resection found that delivery of FOLFOX was independently associated
with higher rates of pathologic complete response, with the highest
Combined-modality therapy consisting of surgery, concurrent complete response rate (38%) following six cycles of neoadjuvant
fluoropyrimidine-based chemotherapy with ionizing radiation to the pelvis FOLFOX and the lowest (18%) in the group that received chemoRT
(chemoRT), and chemotherapy is recommended for the majority of alone.303 However, it is difficult to determine if the higher pathologic
patients with stage II or stage III rectal cancer. Use of perioperative pelvic complete response rate with FOLFOX was due to the increased duration
RT in the treatment of patients with stage II/III rectal cancer continues to of FOLFOX, the longer duration of time between chemoRT and surgery, or
evolve. The current guidelines recommend several possible sequences of some combination of the two.
therapy, depending on predicted CRM status and response to initial
therapy. More recently, the TNT approach has been tested in phase III trials.
RAPIDO, a randomized phase III trial, compared a standard treatment
The Total Neoadjuvant Therapy Approach approach (chemoRT, followed by TME, then optional adjuvant
A treatment approach for stage II or III rectal cancer, including courses of chemotherapy with CAPEOX or FOLFOX) to an experimental TNT
both chemoRT and chemotherapy given as neoadjuvant therapy before approach (short-course RT, followed by chemotherapy before TME) in 912
transabdominal resection, has been gaining prominence. This approach, patients with locally advanced rectal cancer.304 At 3 years after
called TNT, was first tested in several small, phase II trials, but more randomization, the rate of disease-related treatment failure was 23.7%
recently has been supported by phase III trial data.295-300 with TNT compared to 30.4% with standard treatment (HR, 0.75; 95% CI,
0.60–0.95; P = .019). No differences were found in the secondary
In the Spanish GCR-3 randomized phase II trial, patients were randomized
endpoint of OS. Serious adverse events occurred in 38% of the TNT group
to receive CAPEOX either before chemoRT or after surgery.297,301 Similar
and 34% in the standard treatment group. Another randomized phase III
pathologic complete response rates and 5-year DFS and OS were seen,
trial, UNICANCER-PRODIGE 23, compared a neoadjuvant therapy
and induction chemotherapy appeared to be less toxic and better
approach including both FOLFIRINOX and chemoRT prior to TME to a
tolerated. The GCR-3 trial provided the rationale for RAPIDO and
standard approach of neoadjuvant chemoRT alone followed by TME for
demonstrated that the TNT approach increased compliance, lowered
461 patients with locally advanced rectal cancer.305 Both arms followed
acute toxicity, and yielded similar outcomes compared to the traditional
TME by adjuvant FOLFOX, although the duration of adjuvant treatment
approach. A pooled analysis of two phase II trials, EXPERT and EXPERT-
was shorter in the group that had received neoadjuvant chemotherapy.
C, assessed the safety and efficacy of neoadjuvant chemotherapy
After a median follow-up of 46.5 months, 3-year DFS was 76% in the
followed by chemoRT and surgery.302 Of the 269 patients who were
group that received neoadjuvant chemotherapy, compared to 69% in the
included, 91.1% completed chemotherapy, 88.1% completed chemoRT,
standard treatment group (HR, 0.69; 95% CI, 0.49–0.97; P = .034). During
and 89.2% underwent curative surgery. Five-year PFS and OS rates were
the whole treatment period, serious adverse events occurred in 11% of
66.4% and 73.3%, respectively. Another phase II trial comparing response
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NCCN Guidelines Version 4.2024

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patients in the neoadjuvant chemotherapy group and 23% in the standard- received chemotherapy first compared to 9.9% who received chemoRT
of-care group (P = .0049). No postoperative deaths occurred within 30 first. Collectively, these data suggest that the TNT approach of chemoRT
days in the neoadjuvant group, while five deaths occurred in the standard followed by chemotherapy results in a higher rate of pathologic complete
treatment group (4 from cardiac or vascular events, 1 from suicide). response while showing no significant differences in DFS, locoregional
recurrence, distant metastases, or toxicities.
These results have also been supported by systemic review and meta-
analyses showing a higher pathologic complete response rate with A few trials have investigated the use of FOLFIRINOX or FOLFOXIRI as
TNT.306,307 In a single-institution retrospective cohort analysis of patients neoadjuvant chemotherapy for locally advanced rectal cancer. One of
with T3/4 or node-positive rectal cancer, patients in the TNT group these trials was the randomized, phase III UNICANCER-PRODIGE 23
received a greater percentage of the planned chemotherapy dose than study, which was described above.305 The prospective, single-arm phase II
those in the adjuvant chemotherapy group.308 The complete response FORTUNE study investigated the use of FOLFOXIRI as initial therapy for
rates were 36% and 21% in the TNT and adjuvant chemotherapy groups, patients with stage II or III rectal cancer.313 After initial chemotherapy,
respectively. patients were either treated with surgery or RT/chemoRT followed by
surgery, depending on the response to initial FOLFOXIRI. Of 103 patients
It is not established whether it is better to start with chemotherapy, then who completed neoadjuvant therapy, pathologic complete response and
follow with chemoRT, or vice versa when following a TNT approach. tumor downstaging rates were 20.4% and 42.7%, respectively. Another
Results from the phase II Organ Preservation in Rectal Adenocarcinoma phase II trial of patients with node-positive, cT4, or high-risk T3 rectal
(OPRA) trial suggest that initiating treatment with chemoRT may improve cancer investigated the use of induction FOLFOXIRI plus bevacizumab
TME-free survival.309,310 The randomized phase II CAO/ARO/AIO-12 study followed by capecitabine-based chemoRT with bevacizumab.314 Surgery
also looked at this question, comparing TNT approaches using either was performed 8 weeks after completion of the chemoRT. Of 49 enrolled
induction chemotherapy with FOLFOX followed by 5-FU/oxaliplatin patients, 44 completed surgery and 2-year DFS was 80%. While the
chemoRT or chemoRT followed by consolidation chemotherapy.311 This NCCN Panel recommends induction chemotherapy with FOLFIRINOX as
trial reported that upfront chemoRT led to higher completion rates for an option for T4, node-positive rectal cancer, the addition of targeted
chemoRT, but lower completion rates for chemotherapy compared to agents (such as bevacizumab) is not currently recommended in this
upfront chemotherapy. Pathologic complete response was observed in setting. While UNICANCER-PRODIGE 23 enrolled patients with cT3 and
17% of those who received upfront chemotherapy and 25% of those who cT4, node-negative tumors,305 the NCCN Panel only recommends the use
received upfront chemoRT. A secondary analysis reporting long-term of FOLFIRINOX for the cT4, N+ tumors due to the higher toxicity of
(median, 43 months) results from the CAO/ARO/AIO-12 study showed FOLFIRINOX compared to FOLFOX or CAPEOX and the results observed
similar long-term outcomes between the two groups, including 3-year DFS with CAPEOX or FOLFOX in RAPIDO, which enrolled patients at higher
(73% for both groups; HR, 0.95; 95% CI, 0.63–1.45), 3-year incidence of risk of recurrence.304 It is important to note that the trials evaluating TNT
local recurrence (6% vs. 5%), and distant metastases (18% vs. 16%).312 with FOLFIRINOX or FOLFOXIRI compared the TNT regimen to a
Chronic toxicity of grade 3 or higher occurred in 11.8% of patients who standard preoperative chemoRT approach, not to a TNT strategy using

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FOLFOX; therefore, there is insufficient data to compare FOLFOX to Putative advantages to preoperative radiation, as opposed to radiation
FOLFIRINOX in this setting. given postoperatively, are related to both tumor response and preservation
of normal tissue. First, reducing tumor volume may facilitate resection and
The TNT approach has demonstrated benefits including the early increase the likelihood of a sphincter-sparing procedure. Although some
prevention or eradication of micrometastases, higher rates of pathologic studies have indicated that preoperative radiation or chemoRT is
complete response and longer PFS,303-308 minimizing the length of time associated with increased rates of sphincter preservation in patients with
patients need an ileostomy,308 facilitating resection, and improving the rectal cancer,315,317 this conclusion is not supported by two meta-analyses
tolerance and completion rates of chemotherapy.297,303-305 For some of randomized trials involving preoperative chemoRT in the treatment of
patients, surgery may be avoided if a complete response is achieved as a rectal cancer.318,319 Second, irradiating tissue that is surgery-naïve and
result of neoadjuvant therapy (see Watch-and-Wait Nonoperative thus better oxygenated may result in increased sensitivity to RT. Third,
Approach for Clinical Complete Responders, below). Based on this, the preoperative radiation can avoid the occurrence of radiation-induced injury
NCCN Panel recommends TNT as the preferred approach for stage II–III to small bowel trapped in the pelvis by post-surgical adhesions. Finally,
rectal cancer. preoperative radiation that includes structures that will be resected
increases the likelihood that an anastomosis with healthy colon can be
Preoperative Chemoradiation
performed (ie, the anastomosis remains unaffected by the effects of RT
When not using a TNT approach, preoperative chemoRT is recommended
because irradiated tissue is resected).
for patients with stage II/III rectal cancer. Postoperative chemoRT is
recommended when stage I rectal cancer is upstaged to stage II or III after Regimens for Concurrent ChemoRT
pathologic review of the surgical specimen. A number of randomized trials have established the benefit of adding
chemotherapy (most often 5-FU/leucovorin or capecitabine) to RT for
A large, prospective, randomized trial from the German Rectal Cancer
treatment of localized rectal cancer. Putative benefits of the addition of
Study Group (the CAO/ARO/AIO-94 trial) compared preoperative versus
chemotherapy concurrent with RT include local RT sensitization and
postoperative chemoRT in the treatment of clinical stage II/III rectal
systemic control of disease (ie, eradication of micrometastases).
cancer.315 Results of this study indicated that preoperative therapy was
Preoperative chemoRT also has the potential to increase rates of
associated with a significant reduction in local recurrence (6% vs. 13%; P
pathologic complete response and sphincter preservation.
= .006) and treatment-associated toxicity (27% vs. 40%; P = .001),
although OS was similar in the two groups. Long-term follow-up of this trial In a study of patients with T3–4 rectal cancer without evidence of distant
was later published.316 The improvement in local control persisted, with the metastases who were randomly assigned to receive either preoperative
10-year cumulative incidence of local recurrence at 7.1% and 10.1% in the RT alone or preoperative concurrent chemoRT with 5-FU/LV, no
preoperative and postoperative treatment arms, respectively (P = .048). difference in OS or sphincter preservation was observed in the two
OS at 10 years was again similar between the groups (59.6% and 59.9%, groups, although patients receiving chemoRT were significantly more
respectively; P = .85), as was DFS and the occurrence of distant likely to exhibit a pathologic complete response (11.4% vs. 3.6%; P < .05)
metastases.
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NCCN Guidelines Version 4.2024

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and grade 3/4 toxicity (14.6% vs. 2.7%; P < .05) and less likely to exhibit Treatment Group (NCCTG) showed that postoperative administration of
local recurrence of disease (8.1% vs. 16.5%; P < .05).320 infusional 5-FU during pelvic irradiation was associated with longer OS
when compared to bolus 5-FU.327 Most of the patients in this study had
Preliminary results of a phase III trial that included an evaluation of the node-positive disease. The panel considers bolus 5-FU/LV/RT as an
addition of chemotherapy to preoperative RT in patients with T3–4 option for patients not able to tolerate capecitabine or infusional 5-FU.
resectable rectal cancer demonstrated that use of 5-FU/leucovorin (LV)
chemotherapy enhanced the tumoricidal effect of RT when the two Recent studies have shown that capecitabine is equivalent to 5-FU in
approaches were used concurrently.321 Significant reductions in tumor perioperative chemoRT therapy.328,329 The randomized NSABP R-04 trial
size, pTN stage, lymphatic invasion, vascular invasion, and PNI rates were compared the preoperative use of infusional 5-FU with or without
observed.321 More mature results from this trial reported that no significant oxaliplatin to capecitabine with or without oxaliplatin in 1608 patients with
differences in OS were associated with adding 5-FU–based chemotherapy stage II or III rectal cancer.329,330 No differences in locoregional events,
preoperatively or postoperatively.322 DFS, OS, complete pathologic response, sphincter-saving surgery, or
surgical downstaging were seen between the regimens, while toxicity was
The conclusions of these trials have been supported in a 2009 systematic increased with the inclusion of oxaliplatin.
review that included four RCTs.323 In addition, a recent Cochrane review of
six RCTs found that chemotherapy added to preoperative radiation in Similarly, a phase III randomized trial in which 401 patients with stage II or
patients with stage III, locally advanced rectal cancer reduced the risk of III rectal cancer received capecitabine– or 5-FU–based chemoRT either
local recurrence, but had no effect on OS, 30-day mortality, sphincter pre- or postoperatively showed that capecitabine was non-inferior to 5-FU
preservation, and late toxicity.324 Similarly, a separate Cochrane review of with regard to 5-year OS (capecitabine 75.7% vs. 5-FU 66.6%; P = .0004),
stage II and III resectable disease found that the addition of chemotherapy with capecitabine showing borderline significance for superiority (P =
to preoperative radiation enhances pathologic response and improves .053).328 Furthermore, in this trial capecitabine demonstrated a significant
local control, but has no effect on DFS or OS.325 Another recent meta- improvement in 3-year DFS (75.2% vs. 66.6%; P = .034).328 Because of
analysis of five RCTs comparing neoadjuvant chemoRT with neoadjuvant these studies, capecitabine given concurrently with RT is listed in the
radiotherapy reached similar conclusions.291 guidelines as an acceptable alternative to infusional 5-FU in those patients
who are able to manage the responsibilities inherent in self-administered,
With respect to the type of chemotherapy administered concurrently with oral chemotherapy.
RT,293 the equivalence of bolus 5-FU/LV and infusional 5-FU in concurrent
chemoRT for rectal cancer is supported by the results of a phase III trial Addition of oxaliplatin: In attempts to improve on the outcomes achieved
(median follow-up of 5.7 years) in which similar outcomes with respect to with neoadjuvant 5-FU/RT or capecitabine/RT, several large randomized
OS and RFS were observed when an infusion of 5-FU or bolus 5-FU plus phase III trials (ACCORD 12, STAR-01, R-04, CAO/ARO/AIO-04,
LV was administered concurrently with postoperative RT, although FOWARC, and PETACC 6) addressed the addition of oxaliplatin to the
hematologic toxicity was greater in the group of patients receiving bolus 5- regimens. In a planned interim report of primary tumor response in the
FU.326 However, results from an earlier trial from the North Central Cancer STAR-01 trial, grade 3 and 4 adverse events occurred more frequently in

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patients receiving infusional 5-FU/oxaliplatin/RT than in those receiving (P = .03).335 Importantly, oxaliplatin was also added to the adjuvant
infusional 5-FU/RT (24% vs. 8%; P < .001), while there was no difference therapy in the AIO-04 trial but not in the other trials, so cross-trial
in pathologic response between the arms of the study (16% pathologic comparisons are limited.
complete response in both arms).331 Results of the NSABP R-04 trial also
showed that the addition of oxaliplatin did not improve clinical outcomes In line with CAO/ARO/AIO-04, early results from the Chinese FOWARC
including the endpoints of locoregional events, DFS, OS, pathologic phase III open-label, multicenter trial, which randomized patients with
complete response, sphincter-saving surgery, and surgical downstaging, locally advanced rectal cancer to neoadjuvant treatment consisting of
while it increased toxicity.329,330 infusional 5-FU/LV-RT, FOLFOX-RT, or FOLFOX, found that FOLFOX-RT
resulted in higher rates of pathologic complete response and downstaging
Similar results were seen in the ACCORD 12/0405-Prodige 2 trial, in than the other regimens.338 However, final results from FOWARC showed
which capecitabine/RT (45 Gy) was compared to CAPEOX/RT (50 Gy) no significant improvement in 3-year DFS, local recurrence rates, or OS
and the primary endpoint was pathologic complete response.332 The for FOLFOX with or without RT compared to 5-FU/LV-RT.339
pathologic complete response rates were similar at 19.2% and 13.9% (P =
.09) for the oxaliplatin-containing arm and the control arm, respectively. Another randomized, multicenter, phase III trial looked at the addition of
Although patients treated with oxaliplatin and the higher radiation dose in oxaliplatin during concurrent capecitabine chemoRT in the adjuvant setting
the ACCORD 12 trial had an increased rate of minimal residual disease at for pathologic stage II/III disease.340 Interim analysis showed no significant
the time of surgery (39.4% vs. 28.9%; P = .008), this did not translate to difference in 3-year DFS, OS, local recurrences, or distant metastases,
improved local recurrence rates, DFS, or OS at 3 years. The results did with an increase in grade 3/4 acute toxicity in the CAPEOX-RT group.
not change after longer term follow-up.333 The PETACC 6 trial also
Based on the results available to date, the addition of oxaliplatin to
investigated whether the addition of oxaliplatin to pre- and postoperative
neoadjuvant chemoRT is not recommended at this time.
capecitabine would improve DFS for locally advanced rectal cancer.334
Similar to other trials, oxaliplatin was found to impair tolerability without Addition of targeted agents: The randomized phase II EXPERT-C trial
improving efficacy. assessed complete response rate with the addition of cetuximab to
radiation treatment in 165 patients.341 Patients in the control arm received
Results of the German CAO/ARO/AIO-04 trial have been published.335,336
CAPEOX followed by capecitabine/RT, then surgery followed by
This trial also assessed the addition of oxaliplatin to a fluorouracil RT
CAPEOX. Patients randomized to the cetuximab arm received the same
regimen. In contrast to STAR-01, R-04, and ACCORD 12, higher rates of
therapy with weekly cetuximab throughout all phases. A significant
pathologic complete response were seen in the oxaliplatin arm (17% vs.
improvement in OS was seen in patients with KRAS exon 2/3 wild-type
13%, P = .038),336 but this result could be because of differences in the
tumors treated with cetuximab (HR, 0.27; 95% CI, 0.07–0.99; P = .034).
fluorouracil schedule between the arms.337 The primary endpoint of this
However, the primary endpoint of complete response rate was not met,
trial, the 3-year DFS rate, was 75.9% (95% CI, 72.4%–79.5%) in the
and other phase II trials have not shown a clear benefit to the addition of
oxaliplatin arm versus 71.2% (95% CI, 67.6%–74.9%) in the control group

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NCCN Guidelines Version 4.2024

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cetuximab in this setting.342,343 Further evaluation of this regimen is At this time the panel does not endorse the use of bevacizumab,
warranted. cetuximab, panitumumab, irinotecan, or oxaliplatin with concurrent
radiotherapy for rectal cancer.
The randomized, multicenter, phase II SAKK 41/07 trial evaluated the
addition of panitumumab to preoperative capecitabine-based chemoRT in Preoperative Systemic Therapy Without Chemoradiation
patients with locally advanced, KRAS wild-type rectal cancer.344 The A small, single-center, phase II pilot trial treated patients with stage II or III
primary endpoint was pathologic near-complete plus complete tumor rectal cancer with induction FOLFOX/bevacizumab chemotherapy
response, which occurred in 53% (95% CI, 36%–69%) of patients in the followed by chemoRT only in those with stable or progressive disease and
panitumumab arm versus 32% (95% CI, 16%–52%) in the control arm. resection in all patients.352 All 32 of the participants had an R0 resection,
Patients receiving panitumumab experienced increased rates of grade 3 or and the 4-year DFS was 84% (95% CI, 67%–94%). Another phase II trial,
greater toxicity. which included 60 patients with stage II/III rectal cancer (excluding cT4b)
from eight institutions, assessed the R0 resection rate after FOLFOX plus
Another phase II study, RaP Study/STAR-03, also assessed the potential
either bevacizumab or cetuximab.353 An R0 resection was achieved in
role of panitumumab in neoadjuvant chemoRT in patients with KRAS wild-
98.3% of the participants, and the pathologic complete response rate was
type, cT3, N0 or cT2–3, N1–2, mid to low rectal cancer with a predicted
16.7%.
negative CRM.345 All patients were treated with panitumumab-chemoRT
followed by resection and adjuvant FOLFOX. The primary endpoint of The phase III FOWARC trial, discussed above, compared neoadjuvant
pathologic complete response was observed in 10.9% (95% CI, 4.7%– therapy with and without radiation (without additional therapy for those
17.1%) of participants, not meeting the pre-specified level of 16%. with stable or progressive disease) and found that neoadjuvant FOLFOX
without radiation gave lower rates of pathologic complete response than
A phase II study of 57 patients with resectable T3/T4 rectal cancer
regimens that included radiation (6.6% vs. 14.0% for 5-FU-RT and 27.5%
evaluated preoperative treatment with capecitabine, oxaliplatin,
for FOLFOX-RT).338 The rate of downstaging in the FOLFOX group was
bevacizumab, and RT, followed by surgery 8 weeks later and adjuvant
similar to the 5-FU-RT group but lower than the FOLFOX-RT group
FOLFOX/bevacizumab.346 The 5-year OS rate was 80%, and the 5-year
(35.5% vs. 37.1% for 5-FU-RT and 56.4% for FOLFOX-RT). However,
RFS rate was 81%. However, the primary endpoint of pathologic complete
final results from FOWARC showed no significant improvement in DFS,
response was not met, significant toxicities were observed, and
local recurrence rates, or OS for FOLFOX with or without RT compared to
compliance with adjuvant therapy was low. Other randomized trials have
5-FU/LV-RT.339 Three-year DFS was 72.9%, 77.2%, and 73.5% (P =
also investigated the use of targeted therapies (eg, bevacizumab, ziv-
.709); 3-year local recurrence rate after resection was 8.0%, 7.0%, and
aflibercept) within neoadjuvant therapy for localized rectal cancer with
8.3% (P = .873); and 3-year OS was 91.3%, 89.1%, and 90.7% (P = .971)
mixed conclusions.314,347-351
for 5-FU/LV-RT, FOLFOX-RT, and FOLFOX without RT, respectively.

A 2015 systematic review identified one randomized phase III trial, six
single-arm phase II trials, and one retrospective case series study that
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NCCN Guidelines Version 4.2024

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addressed the effectiveness of neoadjuvant chemotherapy (without Technical Aspects of Radiation Therapy
chemoRT) and surgery in patients with locally advanced rectal cancer.354 Multiple RT fields should include the tumor or tumor bed with a 2- to 5-cm
The ranges of R0 resection and pathologic complete response rates were margin, the mesorectum, the presacral nodes, and the internal iliac nodes.
90% to 100% and 4% to 33%, respectively. The external iliac nodes should also be included for T4 tumors involving
anterior structures; inclusion of the inguinal nodes for tumors invading into
The N1048/C81001/Z6092 PROSPECT trial by the Alliance for Clinical the distal anal canal can also be considered. Recommended doses of
Trials in Oncology is also asking whether chemotherapy alone is effective radiation are typically 45 to 50 Gy in 25 to 28 fractions to the pelvis using
in treating stage II or III high rectal cancer in patients with at least 20% three or four fields. Positioning and other techniques to minimize radiation
tumor regression following neoadjuvant treatment (clinicaltrials.gov to the small bowel are encouraged. The Radiation Therapy Oncology
NCT01515787). Accrual for this trial has been closed and results are Group (RTOG) has established normal pelvic contouring atlases (available
awaited. online at https://seor.es/wp-
This approach could spare patients the morbidities associated with content/uploads/2014/03/RTOGAnorectalContouringGuidelines-1.pdf).356
radiation, but the panel considers it investigational at this time for most Intensity-modulated RT (IMRT) should be considered for clinical situations
patients with stage II/III rectal cancer. One exception is the panel’s such as re-irradiation of previously treated recurrent disease, patients
recommendation of adjuvant FOLFOX or CAPEOX alone as an option for treated postoperatively due to increased acute or late toxicity, T4 primary
pT3, N0, M0, margin-negative tumors, high in the rectum or at the tumors given the more anterior field changes with coverage of the external
rectosigmoid junction. However, this approach is only appropriate in this iliac nodes, which includes more small bowel, or unique anatomical
small subset of tumors that behave more like colon tumors, and therefore situations where IMRT facilitates the delivery of recommended target
may be treated as such. volumes while respecting accepted normal tissue dose-volume
constraints.357 Ablative stereotactic body radiotherapy (SBRT) should only
The checkpoint inhibitor, dostarlimab-gxly, has also been investigated as be used in the setting of a clinical trial or in the setting of oligometastasis
neoadjuvant therapy in a small phase II study of patients with dMMR/MSI- to the lung, liver, or an abdominopelvic node when other modalities are not
H stage II or III rectal cancer.355 In this study, patients were initially treated appropriate.
with dostarlimab-gxly for 6 months, with chemoRT and surgery planned for
those with residual disease. Remarkably, all 12 patients in this trial Coordination of preoperative chemoRT and surgery is important. Although
showed a complete clinical response to dostarlimab-gxly and no patients longer intervals from completion of chemoRT to surgery have been shown
at the date of publication had required chemoRT or surgery. No cases of to be associated with an increase in pathologic complete response
progression or recurrence were reported during follow-up (range, 6–25 rates,358-363 it is unclear whether such longer intervals are associated with
months). While this data is encouraging, it has not yet been added as a clinical benefit. Results of one NCDB analysis suggest that an interval of
recommended treatment approach in the guidelines. greater than 8 weeks is associated with increased odds of pathologic
complete response,364 whereas other similar analyses concluded that an
interval greater than 56 or 60 days (8–8.5 weeks) is associated with higher

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NCCN Guidelines Version 4.2024

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rates of positive margins, lower rates of sphincter preservation, and/or significantly affected despite improvements in local control of disease.372-
shorter survival.365,366 A pooled analysis of seven randomized trials 374 A more recent multicenter, randomized study of 1350 patients with

concluded that the best time to achieve pathologic complete response was rectal cancer compared 1) short-course preoperative RT and no
at 10 weeks following neoadjuvant chemoRT, with 95% of pathologic postoperative treatment with 2) no preoperative RT and a postoperative
complete response events occurring within that time period.367 approach that included chemoRT in selected patients (ie, those with a
positive CRM following resection) and no RT in patients without evidence
The GRECCAR-6 phase III, multicenter, randomized, open-label, parallel- of residual disease following surgery.375 Results indicated that patients in
group controlled trial randomized patients with stage II/III rectal cancer the preoperative RT arm had significantly lower local recurrence rates and
treated with chemoRT to a 7- or 11-week interval before surgery.368 The a 6% absolute improvement in 3-year DFS (P = .03), although no
pathologic complete response rate was not different between the groups difference in OS was observed between the arms of the study.375,376
(15.0% vs. 17.4%; P = .60), but the morbidity (44.5% vs. 32%; P = .04),
medical complications (32.8% vs. 19.2%; P = .01), and rate of complete Long-term (12 years) follow-up of one of the short-course RT trials (the
mesorectal resection (78.7% vs. 90%; P = .02) were worse in the 11-week Dutch TME trial373) was reported.377 The analysis showed that 10-year
group. The rate of anastomotic leaks and the mean length of hospital stay survival was significantly improved in patients with stage III disease and a
were similar between the groups. Three-year survival results from the negative CRM in the RT plus surgery group compared to the group that
GRECCAR-6 trial showed no difference in 3-year OS (P = .8868), DFS (P received surgery alone (50% vs. 40%; P = .032).377 However, this long
= .9409), distant recurrence (P = .7432), or local recurrence (P = .3944) follow-up showed that secondary malignancies and other non-rectal
between the 7- or 11-week interval groups.369 cancer causes of death were more frequent in the RT group than in the
control group (14% vs. 9% for secondary malignancies), negating any
Short-Course Radiation survival advantage in the node-negative subpopulation.
Several European studies have looked at the efficacy of a shorter course
of preoperative RT (25 Gy over 5 days), not combined with chemotherapy, A few studies have compared short-course RT to long-course chemoRT.
for the treatment of rectal cancer. The results of the Swedish Rectal One randomized study of 312 patients in Poland directly compared
Cancer Trial evaluating the use of short-course RT administered preoperative short-course RT and more conventional preoperative long-
preoperatively for resectable rectal cancer showed a survival advantage course chemoRT and found no differences in local recurrence or
and a decreased rate of local recurrence with this approach compared survival.378 Similarly, an Australian/New Zealand trial (Trans-Tasman
with surgery alone.370 However, a follow-up study published in 2005 Radiation Oncology Group [TROG] trial 01.04) that randomized 326
showed that the patients with short-course preoperative RT had increased patients to short-course RT or long-course chemoRT found no differences
RR for postoperative hospitalization due to bowel obstructions and other in local recurrence and OS rates.379 In addition, rates of late toxicity,
gastrointestinal complications.371 A number of other studies also distant recurrence, and RFS were not significantly different between the
investigating the effectiveness of preoperative short-course RT in patients arms. Patients in the long-course arm were more likely to experience
with rectal cancer staged as T1–3 have demonstrated that OS was not serious adverse events (eg, radiation dermatitis rates, 0% vs. 5.6%; P =

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NCCN Guidelines Version 4.2024

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.003), whereas patients in the short-course arm were more likely to have a the two arms. A more mature analysis of the RAPIDO trial reported that in
permanent stoma (38.0% vs. 29.8%; P = .13).380 However, no overall 920 randomized patients, pathologic complete response rates were 28%
difference was seen in health-related quality of life between the groups.381 for the short-course arm compared to 14% for the long-course arm (OR,
Finally, a trial compared short-course RT with long-course chemoRT with 2.37; 95% CI, 1.67–3.37; P < .0001).304 The primary outcome of 3-year
delayed surgery in both groups.382 Although the long-course arm disease-related treatment failure was lower in the short-course arm
experienced greater tumor downsizing and downstaging compared with compared to the long-course arm (23.7% vs. 30.4%; HR, 0.75 [0.60–0.95];
short-course treatment, no differences were seen in the R0 resection rates P = .019). Probability of distant metastasis and locoregional disease
or postoperative morbidity. The 3-year DFS was better in the long-course progression was also lower for the short-course RT arm compared to the
arm than in the short course arm (75% vs. 59%; P = .022), with no long-course RT arm. Overall health, quality of life, and LAR syndrome
difference in OS.383 score were comparable between the two treatment arms.304,387
Subsequently, an abstract reporting patterns of locoregional disease
The randomized phase III Polish II study randomized patients with progression and distant metastases in the RAPIDO trial reported an
cT3/cT4 rectal cancer to either preoperative short-course radiation increase in locoregional disease progression at 5 years for the short-
followed by FOLFOX4 or preoperative long-course chemoRT with bolus 5- course RT arm compared to long-course (7% vs. 10%; HR, 1.60).388
FU/LV and oxaliplatin.384 Of 515 patients eligible for analysis, preoperative Therefore, caution should be exercised in the use of short-course RT for
acute treatment toxicity was lower with short-course RT (P = .006). No high-risk rectal cancer.
differences in local efficacy or 3-year DFS were observed between the
groups, although 3-year OS was higher for the short-course group (73% Stockholm III was another randomized, phase III study that compared
vs. 65%, P = .046). However, long-term results of this trial showed no short-course RT to long-course RT in 840 patients with resectable rectal
difference in 8-year OS (49% for both groups).385 The rate of late cancer.389,390 This trial included two randomizations, a two-arm
complications was also similar between the two groups. randomization that compared short-course RT with immediate surgery to
short-course RT with delayed surgery (described below), and a three-arm
The randomized RAPIDO trial assessed the use of preoperative short- randomization that compared short-course RT with immediate surgery,
course (5 x 5 Gy) RT followed by 6 cycles of CAPEOX or 9 cycles of short-course RT with delayed surgery, and long-course RT with delayed
FOLFOX4 compared to long-course (25–28 x 2.0–1.8 Gy) capecitabine- surgery. For the 385 patients in the three-arm randomization, the
based chemoRT before resection in patients with clinical stage T3 or T4 incidence of local recurrence was 2.3% for short-course with immediate
rectal cancer. Early results of 901 evaluable patients showed a high surgery, 3.1% for short-course with delayed surgery, and 5.4% for long-
percentage of patients who completed at least 75% of their prescribed course RT with a median follow-up of 5.7 years.389 Median OS was 8.1,
chemotherapy (84% for the short-course arm compared to 57% in the 10.3, and 10.5 years for short-course RT with immediate surgery, short-
long-course arm).386 While considerable toxicity did occur during course with delayed surgery, and long-course RT respectively. No
preoperative therapy, there were no significant differences noted in the comparisons showed statistically significant differences and long-term
surgical procedures performed or postoperative complications between health-related quality of life was also similar between the groups.

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STELLAR is a randomized, phase III trial that compared short-course RT rectal cancer. A multidisciplinary evaluation, including a discussion of the
followed by CAPEOX to capecitabine-based long-course chemoRT as need for downstaging and the possibility of long-term toxicity, is
neoadjuvant therapy in 599 patients with stage 2–3 rectal cancer.391 Both recommended when considering short-course RT.
groups received TME 6 to 8 weeks after preoperative treatment and
adjuvant chemotherapy was given based on preoperative treatment. Response to Neoadjuvant Treatment
Three-year DFS was 64.5% for short-course RT and 62.3% for long- Fifty percent to 60% of patients are downstaged following neoadjuvant
course chemoRT. There was also no significant difference in metastasis- therapy, with about 20% of patients showing a pathologic complete
free survival or locoregional recurrence between the two groups. Three- response.393-399 Recent studies have suggested that the response to
year OS was higher in the short-course RT group (86.5% vs. 75.1%; P = neoadjuvant treatment correlates with long-term outcomes in patients with
.033), but the prevalence of acute grade ≥3 toxicities during preoperative rectal cancer. In the MERCURY prospective cohort trial, 111 patients were
treatment was higher with short-course RT (26.5% vs. 12.6%; P < .001). assessed by MRI and pathologic staging.400 On multivariate analysis, MRI-
assessed tumor regression grade was significantly associated with OS
A 2014 systematic review identified 16 studies (RCTs, phase II trials, and and DFS. Patients with poor tumor regression grade had 5-year survival
retrospective studies) that addressed the interval between short-course rates of 27% versus 72% for patients with good tumor regression grade (P
RT and resection of rectal cancer.392 Lower rates of severe acute post- = .001), and DFS rates were 31% versus 64% (P = .007). Similarly, in the
radiation toxicity but higher rates of minor postoperative complications CAO/ARO/AIO-94 trial, patients with pathologic complete regression had
were seen in the immediate-surgery group (1- to 2-week interval) 10-year cumulative incidence of distant metastasis and DFS of 10.5% and
compared with the delayed surgery group (5- to 13-week interval). The 89.5%, respectively, while those with poor regression had corresponding
pathologic complete response rates were significantly higher in the incidences of 39.6% and 63%.401 A recent retrospective review of 725
delayed-surgery group, with no differences in sphincter preservation and patients with rectal cancer found similar results.397 In this study,
R0 resection rates. The Stockholm III trial also investigated the optimal pathologically determined response to neoadjuvant treatment correlated
interval between short-course radiotherapy and surgery in 455 patients with long-term outcomes. Five-year RFS rates were 90.5%, 78.7%, and
within the two-arm randomization.389,390 This trial showed similar oncologic 58.5% for patients with complete, intermediate, and poor responses,
outcomes and long-term health-related quality of life between the respectively (P < .001). Distant metastases and local recurrences also
immediate surgery versus 4 to 8 weeks delay following short-course RT correlated with the level of response. Other studies have also shown a
groups,389 but a lower rate of postoperative complications in the group that prognostic effect of response to neoadjuvant treatment.402,403
delayed surgery following short-course RT (53% vs. 41%; OR, 0.61; 95%
CI, 0.45–0.83; P = .001).390 In addition to its prognostic value, there is some initial evidence of
predictive value to neoadjuvant treatment response. Subgroup analysis of
Overall, it appears that short-course RT gives effective local control and the EORTC 22921 trial showed that patients downstaged to ypT0–2 were
the same OS as more conventional RT schedules, and therefore is more likely to benefit from adjuvant chemotherapy than patients with
considered as an appropriate option for patients with locally advanced

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NCCN Guidelines Version 4.2024

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ypT3–4 staging.393 Similar results were seen from another retrospective Other non-randomized, prospective studies have added to the growing
review.404 evidence that the nonoperative approach may warrant further study.408-410
For example, one study showed that 49% of patients experienced a
Watch-and-Wait Nonoperative Approach for Clinical Complete complete clinical response after 5-FU–based chemoRT, and found that
Responders
strict surveillance in these patients, with resection of recurrences when
As preoperative treatment and imaging modalities have improved, some possible, resulted in a 5-year RFS of 69%, which rose to 94% after
have suggested that patients with a clinical complete response to resections were performed.409 A retrospective case series analysis
chemoRT may be able to be spared the morbidities of surgery. In 2004, compared patients who agreed to a watch-and-wait strategy after having a
Habr-Gama et al405 retrospectively compared the outcomes of 71 patients clinical complete response on neoadjuvant therapy with those who
who were observed without surgery following complete clinical response underwent surgery following neoadjuvant therapy and were found to have
(27% of patients) to the outcome of 22 patients (8%) who had incomplete a pathologic complete response at resection.411 This study found that the
clinical responses but complete pathologic responses post-TME. The OS watch-and-wait strategy resulted in excellent rectal preservation and pelvic
and DFS rates at 5 years were 100% and 92%, respectively, in the tumor control. However, worse survival and a higher incidence of distant
nonoperative group compared to 88% and 83%, respectively, in the tumor progression were noted in patients in the watch-and-wait group with
resected group. However, other studies did not achieve as impressive local regrowth versus those without. Several systematic reviews have
results, and many clinicians were skeptical of the approach.406 been published on the nonoperative approach.412-414 They all show that the
approach is likely safe with the use of resection in patients with tumor
A more recent prospective study included a more thorough assessment of
regrowth, but that the data are very limited.
treatment response and used very strict criteria to select 21 of 192
patients (11%) with clinical complete responses who were then observed The International Watch & Wait Database (IWWD) aims to collect data to
with careful follow-up and compared to 20 patients with a complete expand knowledge on the benefits, risks, and safety of organ preservation
pathologic response after resection.407 Only one patient in the in rectal cancer using a large-scale registry of pooled individual patient
nonoperative group developed a local recurrence after a mean follow-up of data from multiple institutions. A 2018 analysis included data from 880
25 months; that patient underwent successful surgery. No statistical patients in the IWWD with disease that had a complete clinical response
differences in long-term outcomes were seen between the groups. The following neoadjuvant therapy and were managed by watch-and-wait.415 In
cumulative probabilities for 2-year DFS and OS were 89% (95% CI, 43%–
this analysis, the 2-year incidence of local recurrence was 25.2% and 88%
98%) and 100%, respectively, in the watch-and-wait group and 93% (95%
of local recurrences occurred in the first 2 years. Distant metastases
CI, 59%–99%) and 91% (95% CI, 59%–99%), respectively, in the resected
occurred in 8% of patients, 5-year OS was 85%, and 5-year disease-
group. Short-term functional outcomes, however, were better in the watch-
specific survival was 94%. A 2021 analysis of the IWWD showed similar
and-wait group, with better bowel function scores, less incontinence, and
results.416 This analysis included 793 patients with clinical complete
10 patients avoiding permanent colostomy.
response who were managed using the watch-and-wait strategy. With a
median follow-up of 55.2 months, the probability of remaining free of local

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NCCN Guidelines Version 4.2024

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recurrence for an additional 2 years was 88.1% after 1 year of DFS, 97.3% considered in centers with experienced multidisciplinary teams after a
after 3 years of DFS, and 98.6% after 5 years of DFS. These same careful discussion with the patient about their risk tolerance.
measures for distant metastasis free survival was 93.8% for 1 year, 97.8%
for 3 years, and 96.6% for 5 years. Together, current data from the IWWD Careful surveillance is essential for those considering a watch-and-wait
suggests that disease recurrence occurs most frequently in the first 2 to 3 approach in order
years following complete response and a more intense surveillance
to treat tumor regrowth in a timely manner. The OPRA trial included the
schedule is recommended for that time period.415,416
following surveillance protocol for watch-and-wait: DRE, flexible
The OPRA trial is a randomized, phase II trial of the watch-and-wait sigmoidoscopy, and CEA every 4 months for the first 2 years, then every 6
approach.310 OPRA assessed the outcomes of 324 patients with stage II or months for years 3 to 5; MRI every 6 months for the first 2 years, then
III rectal cancer treated with TNT using either an induction chemotherapy every 12 months for years 3 to 5; CT chest/abdomen/pelvis once a year
followed by chemoRT approach or an approach using chemoRT followed for 5 years; and colonoscopy once at year 1 and again at year 5.310 Watch-
by consolidation chemotherapy. Following neoadjuvant treatment, patients and-wait surveillance protocols are an area of active investigation and
received either TME or observation (watch-and-wait) based on tumor other protocols have been suggested.415,416,420 The watch-and-wait
response. Organ preservation was achievable in about half of patients surveillance schedule recommended by the NCCN Panel based on clinical
treated with TNT on OPRA with 3-year TME-free survival of 41% in the and institutional experiences is similar to the OPRA protocol and includes
induction chemotherapy group and 53% in the consolidation DRE and proctoscopy every 3 to 4 months for 2 years, then every 6
chemotherapy group. The primary endpoint of DFS was 76% for both months for the next 3 years, and MRI of the rectum every 6 months for at
groups, which is in line with the 75% 3-year DFS rate observed least 3 years.
historically. No differences were observed between the groups for RFS,
The use of nonoperative management of rectal cancer has been
distant metastasis-free survival, or OS.
increasing in the United States, likely representing some early adoption of
Despite the impressive results of prospective trials, many still believe that the approach described herein as well as disparities in the receipt of
longer follow-up, larger sample sizes, and additional careful observational appropriate rectal cancer resection.421
studies are needed before patients with a clinical complete response are
Adjuvant Chemotherapy
routinely managed by a watch-and-wait approach.417 Furthermore, recent
Adjuvant chemotherapy is recommended for patients with stage II/III rectal
studies have found that neither FDG-PET, nor MRI, nor CT can accurately
cancer following neoadjuvant chemoRT and surgery if they did not receive
determine a pathologic complete response, complicating the selection of
neoadjuvant chemotherapy regardless of the surgical pathology results;
appropriate patients for a nonoperative approach.212-220,418 In addition,
however, few studies have evaluated the effect of adjuvant chemotherapy
lymph node metastases are still seen in a subset of patients with
in patients with rectal cancer, and its role is not well-defined.422,423 The
pathologic complete response.419 Keeping these caveats in mind, the
addition of 5-FU adjuvant chemotherapy to preoperative chemoRT
panel believes that a nonoperative management approach may be
provided no benefit to the rate of local recurrence in the EORTC

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Radiotherapy Group Trial 22921.322 However, this study showed an additional adjuvant chemotherapy found 5-year DFS and OS rates of 96%
improvement in DFS (HR, 0.87; 95% CI, 0.72–1.04; P = .13) of patients and 100%, respectively.430 In addition, a meta-analysis of four randomized
receiving adjuvant chemotherapy (+/- RT) following preoperative RT (+/- 5- trials (1196 patients) concluded that adjuvant fluorouracil-based
FU–based chemotherapy).322 Long-term results of the 22921 trial chemotherapy (5-FU/LV, capecitabine, or CAPEOX) after preoperative
confirmed that adjuvant 5-FU chemotherapy did not improve OS, and the therapy and surgery did not improve OS, DFS, or the rate of distant
difference in DFS was less pronounced than following the previous recurrences in patients with stage II or III rectal cancer.431 However, more
analysis (HR, 0.91; 95% CI, 0.77–1.08; P = .29).424 Limitations of this trial recent trials that found a DFS benefit to the addition of adjuvant
include the fact that only 43% of participants received the full course of oxaliplatin-based adjuvant therapy were not included in this study, and
adjuvant chemotherapy. Other trials have shown no improvement in OS or other meta-analyses have reached the opposite conclusion.432,433 A
DFS with adjuvant therapy with a fluoropyrimidine alone in this systematic review published in 2017 identified eight phase III trials and
setting.425,426 one randomized phase II trial comparing adjuvant chemotherapy with
observation in patients with nonmetastatic rectal cancer treated with
Other trials have investigated the use of more modern agents in the neoadjuvant chemoRT.434 The authors report that the data are not robust
adjuvant setting. The phase III ECOG E3201 trial was designed to enough to warrant routine use of adjuvant therapy in this population. Most
investigate the effect of adding either oxaliplatin (FOLFOX) or irinotecan database studies have also failed to see much of a benefit to adjuvant
(FOLFIRI) to 5-FU/LV-based adjuvant chemotherapy administered to chemotherapy in this setting.435-437 However, two similar analyses that
patients with stage II/III rectal cancer after either preoperative or used the NCDB from 2006 to 2013 or from 2006 and 2012 and that looked
postoperative chemoRT. This study was replaced with an alternative trial only at patients achieving a pathologic complete response after
with bevacizumab, but results from an initial 165 patients indicate that neoadjuvant chemoRT (n = 2891; n = 2764) found a significant
adjuvant FOLFOX can be safely used in this patient population.427 The improvement in OS with the use of adjuvant chemotherapy.438,439 Another
open-label phase II ADORE trial randomized 321 patients with resected analysis of the NCDB from the same time period reported that while
rectal cancer and neoadjuvant therapy to adjuvant 5-FU/LV or FOLFOX.428 oxaliplatin-based adjuvant therapy was associated with improved OS in
The FOLFOX arm had higher 3-year DFS, at 71.6% versus 62.9% (HR, patients with pathologic stage III disease, this association was not seen in
0.66; 95% CI, 043–0.99; P = .047). A long-term analysis confirmed these patients with pathologic stage 0 or 1 disease.440 Therefore, the authors of
results with a 6-year DFS of 68.2% in the FOLFOX arm compared to this study conclude that oxaliplatin may be omitted from adjuvant therapy
56.8% in the 5-FU/LV arm (HR, 0.63; 95% CI, 0.43–0.93; P = .018).429 The for tumors that exhibit a pathologic complete response.
CAO/ARO/AIO-04 trial found an improvement in 3-year DFS when
oxaliplatin was added to 5-FU in both neoadjuvant and adjuvant treatment A randomized, phase III study of the ECOG-ACRIN Research Group
(75.9% vs. 71.2%; P = .03).335 (E5204) compared FOLFOX alone to FOLFOX in combination with
bevacizumab as adjuvant treatment for patients with stage II or III rectal
A study in which patients who received neoadjuvant chemoRT and cancer who had already undergone neoadjuvant chemoRT and complete
experienced a pathologic complete response were observed without resection.441 While the trial was terminated due to poor accrual, in the 355

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registered patients, no difference was seen in 5-year OS or 5-year DFS resection (preferred) followed by adjuvant therapy based on pathologic
between the two arms. However, the bevacizumab-containing arm had stage (see Adjuvant Treatment Recommendations for cT1–2 N0 Rectal
higher rates of early therapy discontinuation and patient withdrawal from Cancer, below); or 2) chemoRT. For patients treated with transanal local
the trial. excision and then chemoRT, options for the next phase of treatment
depend on whether there is evidence of residual disease. If there is no
A 2011 systematic review and meta-analysis of 10 studies involving more evidence of disease, observation or chemotherapy without resection may
than 15,000 patients with colon or rectal cancer looked at the effect of be considered. If there is evidence of disease, transabdominal resection
timing of adjuvant therapy following primary tumor resection.442 Results of should be performed, with or without adjuvant chemotherapy. Results of a
this analysis showed that each 4-week delay in chemotherapy results in a meta-analysis suggest that transanal local excision followed by chemoRT
14% decrease in OS, indicating that adjuvant therapy should be without a transabdominal resection may be associated with higher rates of
administered as soon as the patient is medically able. These results are local recurrence than transanal local excision followed by transabdominal
consistent with other similar analyses.443 The optimal duration of adjuvant resection.447 Careful surveillance of patients forgoing transabdominal
treatment in rectal cancer is still unclear.444,445 In the MOSAIC trial, resection in this setting is advised.
patients with stage II/III colon cancer were treated with 6 months of
adjuvant FOLFOX.446 The use of a shorter course of adjuvant FOLFOX in Node-negative T2 lesions are treated with transabdominal resection, since
rectal cancer (ie, 4 months) is justified when preoperative chemoRT is local recurrence rates of 11% to 45% have been observed for T2 lesions
administered. following local excision alone.189,448,449 Following transabdominal resection
of patients with clinical stage T1–2 N0 rectal cancer, patients should
Although conclusive data on the benefits of adjuvant therapy in patients receive adjuvant therapy based on pathologic stage (see Adjuvant
with stage II/III rectal cancer are lacking, the panel recommends adjuvant Treatment Recommendations for cT1–2 N0 Rectal Cancer, below).
treatment with FOLFOX or CAPEOX following resection when not
following the TNT approach. Adjuvant Treatment Recommendations for cT1–2 N0 Rectal Cancer
Patients who had a transabdominal resection for stage cT1–2 rectal
NCCN Recommendations for Nonmetastatic Rectal Cancer cancer are given further treatment based on the pathologic stage. Patients
Recommendations for Patients with T1 and T2 Lesions with tumors staged as pT1–2, N0, M0 require no further treatment. If
Node-negative T1 lesions are treated with transabdominal resection or pathology review reveals pT3, N0, M0, chemoRT, given either before or
transanal local excision, as appropriate. If pathology review after local after chemotherapy, is one option. Observation can also be considered in
excision reveals no high-risk features, then no additional treatment is these patients if the tumor was well-differentiated or moderately well-
required. If, however, pathology review after local excision reveals a poorly differentiated carcinoma invading less than 2 mm into the mesorectum,
differentiated histology, positive margins, invasion into the lower third of without lymphatic or venous vessel involvement and was located in the
the submucosa (sm3 level), or LVI or if the tumor is restaged to pT2, upper rectum.450 Finally, chemotherapy with FOLFOX or CAPEOX alone is
additional treatment is required. The options are: 1) transabdominal an option for margin-negative proximal tumors.

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For resected patients with positive nodes and/or pT4 disease, surgical resection has not yet been adequately characterized. Decisions
chemotherapy and chemoRT can be given sequentially with for nonoperative management should involve a careful discussion with the
chemotherapy followed by concurrent chemoRT or vice-versa.293,326,327 patient of their risk tolerance and a careful surveillance schedule must be
The panel recommends perioperative therapy for a total duration of up to 6 followed. The data supporting this approach are discussed in Watch-and-
months. Wait Nonoperative Approach for Clinical Complete Responders, above.

Recommendations for Patients with T3, N any Lesions with Clear CRM by When a TNT approach is followed, resection should be performed unless
MRI or with T1–2, N1–2 Lesions there is a clear contraindication or a watch-and-wait nonoperative
Patients clinically staged with T3 disease, N any with prediction of clear approach is being pursued. When resection is contraindicated following
margins by MRI have the same treatment options as those clinically primary treatment, patients should be treated with a systemic regimen for
staged as T1–2, N1–2. Prediction of CRM status by MRI is discussed advanced disease (see discussion of Systemic Therapy for Advanced or
above (see Preoperative Pelvic Imaging in Rectal Cancer). Two potential Metastatic Disease in the NCCN Guidelines for Colon Cancer).
treatment courses are recommended for this group of patients, either TNT, FOLFIRINOX is not recommended in this setting.
followed by transabdominal resection or a more traditional perioperative
therapy approach, including both neoadjuvant and adjuvant therapy. Recommendations for Patients with T3, N any Lesions with Involved or
Threatened CRM by MRI, with T4, N any Lesions, with Locally
Of these two options, the preferred approach is TNT, consisting of Unresectable Disease, or Who Are Medically Inoperable
chemotherapy with FOLFOX or CAPEOX given either before or after For patients with higher-risk stage II or III rectal cancer, including cT3
chemoRT. Alternatively, short-course RT may be used in place of long- lesions with involved or threatened CRM by MRI, cT4 lesions, and locally
course chemoRT when following a TNT approach. If short-course RT is unresectable or medically inoperable disease, TNT is the only
considered, its feasibility should be evaluated in a multidisciplinary setting recommended approach. This is because a pathologic complete response
with discussion of the need for downstaging and the possibility of long- is less likely following an initial course of only chemoRT or short-course
term toxicity. Following neoadjuvant therapy, the tumor should be restaged RT and the full course of neoadjuvant chemoRT/short-course RT and
prior to transabdominal resection. The second option for the sequence of chemotherapy is warranted prior to resection. In the TNT approach, 12 to
treatment in this population is chemoRT or short-course RT followed by 16 weeks of chemotherapy are followed by chemoRT or short-course RT,
restaging, transabdominal resection, and then adjuvant chemotherapy. restaging, and transabdominal resection. Alternatively, a TNT approach
may start with chemoRT or short-course RT, followed by 12 to 16 weeks
In those patients who achieve a complete clinical response to neoadjuvant of chemotherapy, then restaging and transabdominal resection. FOLFOX
therapy with no evidence of residual disease on digital rectal examination, or CAPEOX are generally used for chemotherapy, although FOLFIRINOX
rectal MRI, and direct endoscopic evaluation, a watch-and-wait is also an option for T4, N+ disease (see The Total Neoadjuvant Therapy
nonoperative management approach may be considered in centers with Approach, above).
experienced multidisciplinary teams. The degree to which risk of local
and/or distant disease progression may be increased relative to standard

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In those patients with a complete clinical response to neoadjuvant therapy colorectal liver disease is associated with a more disseminated disease
with no evidence of residual disease on digital rectal examination, rectal state and a worse prognosis than metastatic colorectal liver disease that
MRI, and direct endoscopic evaluation, a watch-and-wait nonoperative develops metachronously. In a retrospective study of 155 patients who
management approach may be considered in centers with experienced underwent hepatic resection for colorectal liver metastases, patients with
multidisciplinary teams. The degree to which risk of local and/or distant synchronous liver metastases had more sites of liver involvement (P =
disease progression may be increased relative to standard surgical .008) and more bilobar metastases (P = .016) than patients diagnosed
resection has not yet been adequately characterized. Decisions for with metachronous liver metastases.463
nonoperative management should involve a careful discussion with the
patient of their risk tolerance and a careful surveillance schedule must be It has been estimated that more than half of patients who die of CRC have
followed. The data supporting this approach are discussed in Watch-and- liver metastases at autopsy, with metastatic liver disease as the cause of
Wait Nonoperative Approach for Clinical Complete Responders, above. death in most patients.464 Reviews of autopsy reports of patients who died
from CRC showed that the liver was the only site of metastatic disease in
When resection is contraindicated following primary treatment, patients one-third of patients.461 Furthermore, several studies have shown rates of
should be treated with a systemic regimen for advanced disease (see 5-year survival to be low in patients with metastatic liver disease not
discussion of Systemic Therapy for Advanced or Metastatic Disease in the undergoing surgery.457,465 Certain clinicopathologic factors, such as the
NCCN Guidelines for Colon Cancer). presence of extrahepatic metastases, the presence of more than three
tumors, and a disease-free interval of fewer than 12 months, have been
For unresectable cancers, doses higher than 54 Gy may be required; the associated with a poor prognosis in patients with CRC.210,466-470
dose of RT to the small bowel should be limited to 50 Gy. For patients with
T4 tumors or recurrent cancers or if margins are very close or positive, Other groups, including European Society for Medical Oncology (ESMO),
intraoperative RT (IORT),451-455 which involves direct exposure of tumors to have established guidelines for the treatment of mCRC.471 The NCCN
RT during surgery while removing normal structures from the field of recommendations are discussed below.
treatment, may be considered as an additional boost to facilitate resection.
Surgical Management of Colorectal Metastases
Management of Metastatic Disease Studies of selected patients undergoing surgery to remove colorectal liver
Approximately 50% to 60% of patients diagnosed with CRC will develop metastases have shown that cure is possible in this population and should
colorectal metastases,456-458 and 80% to 90% of these patients have be the goal for a substantial number of these patients.457,472 Reports have
unresectable metastatic liver disease.211,457,459-461 Metastatic disease most shown 5-year DFS rates of approximately 20% in patients who have
frequently develops metachronously after treatment for locoregional CRC, undergone resection of liver metastases,467,470 and a recent meta-analysis
with the liver as the most common site of involvement.462 However, 20% to reported a median 5-year survival of 38%.473 In addition, retrospective
34% of patients with CRC present with synchronous liver analyses and meta-analyses have shown that patients with solitary liver
metastases.210,211 Some evidence indicates that synchronous metastatic metastases have a 5-year OS rate as high as 71% following resection.474-

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476Therefore, decisions relating to patient suitability, or potential suitability, in a retrospective analysis, 5-year survival was shown to decrease with
and subsequent selection for metastatic colorectal surgery are critical each subsequent curative-intent surgery, and the presence of extrahepatic
junctures in the management of metastatic colorectal liver disease477 disease at the time of surgery was independently associated with a poor
(discussed further in Determining Resectability). prognosis.491-494 In a more recent retrospective analysis of 43 patients who
underwent repeat hepatectomy for recurrent disease, 5-year OS and PFS
Colorectal metastatic disease sometimes occurs in the lung.456 Most of the rates were reported to be 73% and 22%, respectively.491 A recent meta-
treatment recommendations discussed for metastatic colorectal liver analysis of 27 studies including greater than 7200 patients found that
disease also apply to the treatment of colorectal pulmonary those with longer disease-free intervals; those whose recurrences were
metastases.478-480 A series of 378 patients found that resection of solitary, smaller, or unilobular; and those lacking extrahepatic disease
pulmonary metastases resulted in a 3-year RFS rate of 28% and a 3-year derived more benefit from repeat hepatectomy.495 Panel consensus is that
OS rate of 78%.480 Combined pulmonary and hepatic resections of re-resection of liver or lung metastases can be considered in carefully
resectable metastatic disease have been performed in very highly selected patients.479,496,497
selected cases479,481-485 and an analysis of patients who underwent hepatic
resection followed by subsequent pulmonary resection showed positive Patients with a resectable primary rectal tumor and resectable
outcomes.486 synchronous metastases can be treated with a staged or simultaneous
resection, as discussed below in Recommendations for Treatment of
Evidence supporting resection of extrahepatic metastases in patients with Resectable Synchronous Metastases. For patients presenting with
mCRC is limited. In a recent retrospective analysis of patients undergoing unresectable metastases and an intact primary that is not acutely
concurrent complete resection of hepatic and extrahepatic disease, the 5- obstructed, palliative resection of the primary is rarely indicated, and
year survival rate was lower than in patients without extrahepatic disease, systemic chemotherapy is the preferred initial maneuver (discussed in
and virtually all patients who underwent resection of extrahepatic more detail below in Recommendations for Treatment of Unresectable
metastases experienced disease recurrence.487,488 However, a recent Synchronous Metastases).498
international analysis of 1629 patients with colorectal liver metastases
showed that 16% of the 171 patients (10.4%) who underwent concurrent Local Therapies for Metastases
resection of extrahepatic and hepatic disease remained disease-free at a The standard of care for patients with resectable metastatic disease is
median follow-up of 26 months, suggesting that concurrent resection may surgical resection. Image-guided ablation has historically been used for
be of significant benefit in well-selected patients (ie, those with a smaller patients who are not candidates for surgery.499-501 but is also indicated for
total number of metastases).485 A recent systematic review concluded small metastases that can be treated with margins, in combination with
similarly that carefully selected patients might benefit from this surgery or alone, as long as all visible disease is treated.502 SBRT (also
approach.489 called stereotactic ablative radiotherapy [SABR]) is a reasonable option for
patients who cannot be resected or ablated, as discussed in subsequent
Recent data suggest that a surgical approach to the treatment of recurrent
paragraphs.460,503,504 Many patients, however, are not surgical candidates
hepatic disease isolated to the liver can be safely undertaken.490 However,

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and/or have disease that cannot be ablated with clear margins500 or safely on the use of HAIC include the potential for biliary toxicity461 and the
treated by SBRT. In select patients with liver-only or liver-dominant requirement of specific technical expertise. Panel consensus is that HAIC
metastatic disease that cannot be resected or ablated, other local, should be considered selectively, and only at institutions with extensive
arterially directed treatment options may be offered.505-507 experience in both the surgical and medical oncologic aspects of the
procedure.
A meta-analysis of 90 studies concluded that hepatic arterial infusion
chemotherapy (HAIC), yttrium-90 microsphere radioembolization, and Arterially Directed Embolic Therapy
transcatheter arterial chemoembolization (TACE) have similar efficacy in
Transhepatic Arterial Chemoembolization
patients with unresectable colorectal hepatic metastases.508 Local
TACE involves hepatic artery catheterization to locally deliver
therapies are described in more detail below. The exact role and timing of
chemotherapy followed by arterial occlusion.506 A randomized trial
using non-extirpative local therapies in the treatment of colorectal
compared the arterial delivery of irinotecan-loaded drug-eluting beads
metastases remains controversial.
(DEBIRI) and reported an OS benefit (22 vs. 15 months; P = .031) of
Hepatic Arterial Infusion DEBIRI when compared to systemic FOLFIRI.515 A 2013 meta-analysis
Placement of a hepatic arterial port or implantable pump during surgical identified five observational studies and one randomized trial and
intervention for liver resection with subsequent infusion of chemotherapy concluded that, although DEBIRI appears to be safe and effective for
directed to the liver metastases through the hepatic artery (ie, HAIC) is an patients with unresectable colorectal liver metastases, additional trials are
option (category 2B). In a randomized study of patients who had needed.516 A more recent trial randomized 30 patients with colorectal liver
undergone hepatic resection, administration of floxuridine with metastases to FOLFOX/bevacizumab and 30 patients to
dexamethasone through HAIC and intravenous 5-FU with or without LV FOLFOX/bevacizumab/DEBIRI.517 DEBIRI resulted in an improvement in
was shown to be superior to a similar systemic chemotherapy regimen the primary outcome measure of response rate (78% vs. 54% at 2 months;
alone with respect to 2-year survival free of hepatic disease.461,509 The P = .02).
study was not powered for long-term survival, but a trend (not significant)
Doxorubicin-eluting beads have also been studied; the strongest data
was seen toward better long-term outcome in the group receiving HAIC at
supporting their effectiveness come from several phase II trials in
later follow-up periods.461,510 Several other clinical trials have shown
hepatocellular carcinoma.518-523 A 2013 systematic review concluded that
significant improvement in response or time to hepatic disease
progression when HAIC was compared with systemic chemotherapy, data are not strong enough to recommend TACE for the treatment of
although most have not shown a survival benefit of HAIC.461,511 Results of colorectal liver metastases except as part of a clinical trial.524
some studies also suggest that HAIC may be useful in the conversion of Radioembolization
disease from an unresectable to a resectable status.512-514
A prospective, randomized, phase III trial of 44 patients showed that
Some of the uncertainties regarding patient selection for preoperative radioembolization combined with chemotherapy can lengthen time to
chemotherapy are also relevant to the application of HAIC.472 Limitations progression in patients with liver-limited mCRC following progression on

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initial therapy (2.1 vs. 4.5 months; P = .03).525 The effect on the primary Results from the phase III randomized controlled SIRFLOX trial (yttrium-90
endpoint of time to liver progression was more pronounced (2.1 vs. 5.5 resin microspheres with FOLFOX +/- bevacizumab vs. FOLFOX +/-
months; P = .003). Treatment of liver metastases with yttrium-90 glass bevacizumab) were reported.533 The trial assessed the safety and efficacy
radioembolization in a prospective, multicenter, phase II study resulted in of yttrium-90 radioembolization as first-line therapy in 530 patients with
a median PFS of 2.9 months for patients with colorectal primaries who colorectal liver metastases. Although the primary endpoint was not met,
were refractory to standard treatment.526 In the refractory setting, a CEA with PFS in the FOLFOX +/- bevacizumab arm at 10.2 months versus 10.7
level greater than or equal to 90 and LVI at the time of primary resection months in the FOLFOX/yttrium-90 arm (HR, 0.93; 95% CI, 0.77–1.12; P =
were negative prognostic factors for OS.527 Additional risk factors include .43), a prolonged liver PFS was demonstrated for the study arm (20.5
tumor volume and liver replacement by disease as well as albumin and months for the FOLFOX/yttrium-90 arm vs. 12.6 months for the
bilirubin levels, performance status, and the presence of extrahepatic chemotherapy only arm; HR, 0.69; 95% CI, 0.55–0.90; P = .002).
disease for both glass528 and resin529 microspheres. Several large case Additionally, the SIRFLOX trial reported a higher proportion of patients
series have been reported for yttrium-90 radioembolization in patients with with disease that became technically resectable on the yttrium-90 arm
refractory unresectable colorectal liver metastases, and the technique compared to control (38.1% vs. 28.9%; P < .001).534
appears to be safe with some clinical benefit.528,530,531 Median survival after
radioembolization in the chemorefractory setting has been reported from 9 The FOXFIRE and FOXFIREGlobal studies were performed in the same
to 15.1 months.526-531 Survival at 1 year from radioembolization of patients manner as the SIRFLOX trial with the intention to compile all data and
with heavily pretreated disease varies considerably based on the allow assessment of oncologic outcomes in a larger cohort.535 Pooled data
accumulation of risk factors such as extrahepatic disease, large tumor from 1103 patients in these three prospective trials showed similar findings
size, poor differentiation, higher CEA and alanine transaminase (ALT), and as in the SIRFLOX trial with prolongation of the liver PFS in the group
lower albumin levels.529 treated by radioembolization but no difference in OS and PFS. Of interest
was the finding of a median OS benefit with radioembolization plus
The randomized, phase III EPOCH trial studied the effect of yttrium-90 chemotherapy compared to chemotherapy alone in the subgroup of
radioembolization in 428 patients who had previously experienced disease patients with right-sided primary origin (22.0 vs. 17.1 months; HR, 0.641; P
progression on first-line therapy and were randomized to receive second- = .008).536 Based on these data, further investigation is needed to identify
line therapy with or without yttrium-90 radioembolization.532 The primary the role of radioembolization at earlier stages of disease in patients with
endpoints of median PFS and hepatic PFS were longer with right-sided primary origin.
radioembolization (PFS, 8.0 vs. 7.2 months; HR, 0.69; 95% CI, 0.54–0.88;
P = .0013) and (hepatic PFS, 9.1 vs. 7.2 months; HR, 0.59; 95% CI, 0.46– Whereas very little data show any impact on patient survival and the data
0.77; P < .0001). Overall survival was similar between the two groups supporting its efficacy are limited, toxicity with radioembolization is
(14.0 and 14.4 months) and grade 3 adverse events were reported more relatively low.533,537-539 Consensus amongst panel members is that
frequently with radioembolization (68.5% vs. 49.3%). arterially directed catheter therapy and, in particular, yttrium-90
microsphere selective internal radiation is an option in highly selected

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patients with chemotherapy-resistant/-refractory disease and with arm compared to 55.2%, 30.3%, and 8.9% for the chemotherapy alone
predominant hepatic metastases. arm.502 This study documented a long-term survival benefit for patients
receiving RFA in addition to chemotherapy compared to those treated by
Tumor Ablation
chemotherapy only.
Resection is the standard approach for the local treatment of resectable
metastatic disease. However, patients with liver or lung oligometastases Data on ablative techniques other than RFA are growing.541,552-559
can also be considered for tumor ablation therapy, particularly in cases However, in a comparison of RFA with MW ablation, outcomes were
that may not be optimal for resection.540,541 Ablative techniques include similar with no local tumor progression for metastases ablated with
radiofrequency ablation (RFA),500,542 microwave (MW) ablation, margins greater than 10 mm (A0) and a relatively better control of
cryoablation, and electrocoagulation (irreversible electroporation).543 There perivascular tumors with the use of MW (P = .021).559 Similarly, two recent
is extensive evidence on the use of RFA as a reasonable treatment option studies and a position paper by a panel of experts indicated that ablation
for non-surgical candidates and for recurrent disease after hepatectomy may provide acceptable oncologic outcomes for selected patients with
with small liver metastases that can be treated with clear margins.500,542,544- small liver metastases that can be ablated with sufficient margins.499-501 In
546
the same way, a 2018 systematic review confirmed that MW provides
oncologic outcomes similar to resection.560 Recent publications indicated
A small number of older retrospective studies have compared RFA and that the significance of margin creation is particularly important for RAS-
resection in the treatment of liver or lung metastases.475,547-550 Most of mutant metastases.561-563
these studies have shown RFA to be relatively inferior to resection in
terms of rates of local recurrence and 5-year OS.540,547 Whether the Regarding pulmonary ablation, a large prospective database of two
differences in outcome observed for patients with liver metastases treated French cancer centers enrolled 566 consecutive patients with 1037 lung
with RFA versus resection alone are from patient selection bias, lack of metastases (the majority colorectal in origin) who received initial treatment
treatment assessment based on the ability to achieve margins, technologic with RFA and 136 patients (24%) underwent repeat RFA.564 PFS rates at
limitations of RFA, or a combination of these factors remains unclear.549 years 1 through 4 were 40.2%, 23.3%, 16.4%, and 13.1%, respectively.
Five-year OS after RFA in CRC pulmonary ablation ranged from 40.7% to
A 2012 phase II trial randomized 119 patients to receive systemic 67.5% depending on risk factors. Microwave ablation has been used
treatment alone (FOLFOX with or without bevacizumab) or systemic increasingly within the latest years with a recent report indicating no local
treatment plus RFA, with or without resection.551 No difference in OS was progression for small tumors ablated with margins of at least 5 mm.565
initially seen, but PFS was improved at 3 years in the RFA group (27.6%
vs. 10.6%; HR, 0.63; 95% CI, 0.42–0.95; P = .025). A subsequent analysis A recent multicenter, prospective phase II study (SOLSTICE) included 128
following prolonged follow-up of the same population in this phase II patients with 224 metastatic lung tumors that were targeted by pulmonary
randomized, controlled trial showed that OS was improved in the cryoablation.566 In this trial, investigators demonstrated a local response of
combined modality arm (HR, 0.58; 95% CI, 0.38–0.88, P = .01), with a 3-, the ablated tumor at 1 and 2 years of 85.1% and 77.2%, respectively. With
5-, and 8-year OS of 56.9%, 43.1%, and 35.9% for the combined modality the use of a second cryoablation for recurrent tumor, 1- and 2-year local

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tumor control reached 91.1% and 84.4%, respectively. In this study, 1- and II trial with multiple cancer types, including a small number of CRC origin,
2-year survival rates were 97.6% and 86.6%, respectively. The grade 3 and up to five metastatic lesions in different organs demonstrated an
and grade 4 complication rates were low, at 4.7% and 0.6%. improvement in OS with the addition of SBRT to standard of care
treatment.579 In patients with liver- or lung-limited disease that is not
An emergent indication for ablation is the discontinuation of chemotherapy amenable to complete resection or ablation, SBRT may be considered as
while controlling oligometastatic pulmonary disease.565,567 The median local therapy in centers with expertise. SBRT for the treatment of
chemotherapy-free survival (time interval between ablation and resuming extrahepatic disease can be considered in select cases, or as part of a
chemotherapy or death without chemotherapy) was 12.2 months. Patients clinical trial.
with no extra-pulmonary metastases had a longer median chemotherapy-
free survival compared to those without (20.9 vs. 9.2 months).567 Peritoneal Carcinomatosis
Approximately 17% of patients with mCRC have peritoneal
Resection or ablation (either alone or in combination with resection)
carcinomatosis, with 2% having the peritoneum as the only site of
should be reserved for patients with metastatic disease that is entirely
metastasis. Patients with peritoneal metastases generally have a shorter
amenable to local therapy with adequate margins. Use of surgery,
PFS and OS than those without peritoneal involvement.116,580 The goal of
ablation, or the combination of both modalities, with the goal of less-than-
treatment for most abdominal/peritoneal metastases is palliative, rather
complete eradication of all known sites of disease, is not recommended
than curative, and primarily consists of systemic therapy (see Systemic
other than in the scope of a clinical trial.
Therapy for Advanced or Metastatic Disease in the NCCN Guidelines for
Liver- or Lung-Directed External Beam Radiation Colon Cancer) with palliative surgery or stenting (upper rectal lesions only)
EBRT to the metastatic site can be considered in highly selected cases in if needed for obstruction or impending obstruction.581-583 A prospective
which the patient has a limited number of metastases, including the liver or randomized trial of 46 patients with stage IV rectal cancer and subacute
lung; or the patient is symptomatic; or in the setting of a clinical trial. It large bowel obstruction found that patients who were randomized to
should be delivered in a highly conformal manner and should not be used placement of a self-expandable metal stunt had a significantly lower 1-
in place of surgical resection. The possible techniques include three- year OS rate compared with those who were randomized to primary tumor
dimensional conformal RT (CRT), SBRT,460,503,504,568 and IMRT, which resection.584 The panel cautions that the use of bevacizumab in patients
uses computer-assisted inverse treatment planning to focus radiation to with colon or rectal stents is associated with a possible increased risk of
the tumor site and potentially decrease toxicity to healthy tissue.569-573 bowel perforation.585,586

While colorectal cancer has been shown to be a relatively radioresistant Determining Resectability
histology,574,575 multiple studies have demonstrated effective local control The consensus of the panel is that patients diagnosed with potentially
with minimal toxicity using SBRT in the treatment of liver,569,576 and resectable mCRC should undergo an upfront evaluation by a
lung577,578 metastases. In addition, data on the benefit of using SBRT to multidisciplinary team, including surgical consultation (ie, with an
treat multiple metastatic lesions are emerging. A recent randomized phase experienced hepatic surgeon in cases involving liver metastases) to

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assess resectability status. The criteria for determining patient suitability with significant response to conversion systemic therapy can be converted
for resection of metastatic disease are the likelihood of achieving complete from unresectable to resectable status.540
resection of all evident disease with negative surgical margins and
maintaining adequate liver reserve.587-590 When the remnant liver is Any active metastatic systemic regimen can be used in an attempt to
insufficient in size based on cross-sectional imaging volumetrics, convert a patient’s unresectable status to a resectable status, because the
preoperative portal vein embolization of the involved liver can be done to goal is not specifically to eradicate micrometastatic disease, but rather to
expand the future liver remnant.591 It should be noted that size alone is obtain the optimal size regression of the visible metastases. An important
rarely a contraindication to resection of a tumor. Resectability differs point to keep in mind is that irinotecan- and oxaliplatin-based
fundamentally from endpoints that focus more on palliative measures. chemotherapeutic regimens may cause liver steatohepatitis and sinusoidal
Instead, the resectability endpoint is focused on the potential of surgery to liver injury, respectively.593-597 Studies have reported that chemotherapy-
cure the disease.592 Resection should not be undertaken unless complete associated liver injury (including severe sinusoidal dilatation and
removal of all known tumor is realistically possible (R0 resection), because steatohepatitis) is associated with morbidity and complications following
incomplete resection or debulking (R1/R2 resection) has not been shown hepatectomy for colorectal liver metastases.593,594,597,598 To limit the
to be beneficial.458,587 development of hepatotoxicity, it is therefore recommended that surgery
be performed as soon as possible after the disease becomes resectable.
The role of PET/CT in determining resectability of patients with mCRC is Some of the trials addressing various conversion therapy regimens are
discussed in Recommendations for Treatment of Metachronous discussed below.
Metastases, below.
In a study by Pozzo et al, it was reported that chemotherapy with
Neoadjuvant Therapy and Conversion to Resectability irinotecan combined with 5-FU/LV enabled a significant portion (32.5%) of
The majority of patients diagnosed with metastatic colorectal disease have the patients with initially unresectable liver metastases to undergo liver
unresectable disease. However, for those with liver-limited unresectable resection.589 The median time to progression was 14.3 months, with all of
disease that, because of involvement of critical structures, cannot be these patients alive at a median follow-up of 19 months. In a phase II
resected unless regression is accomplished, preoperative chemotherapy study conducted by the NCCTG,459 42 patients with unresectable liver
is being increasingly considered in highly selected cases in an attempt to metastases were treated with FOLFOX. Twenty-five patients (60%) had
downsize colorectal metastases and convert them to a resectable status. tumor reduction and 17 patients (40%; 68% of the responders) were able
Patients presenting with large numbers of metastatic sites within the liver to undergo resection after a median period of 6 months of chemotherapy.
or lung are unlikely to achieve an R0 resection simply on the basis of a In another study, 1104 patients with initially unresectable colorectal liver
favorable response to chemotherapy, as the probability of complete disease were treated with chemotherapy, which included oxaliplatin in the
eradication of a metastatic deposit by chemotherapy alone is low. These majority of cases, and 138 patients (12.5%) classified as “good
patients should be regarded as having unresectable disease not amenable responders” underwent secondary hepatic resection.466 The 5-year DFS
to conversion therapy. In some highly selected cases, however, patients rate for these 138 patients was 22%. In addition, results from a

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NCCN Guidelines Version 4.2024

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retrospective analysis of 795 previously untreated patients with mCRC hepatotoxicity, it is therefore recommended that surgery be performed as
enrolled in the Intergroup N9741 randomized phase III trial evaluating the soon as possible after the patient becomes resectable.
efficacy of mostly oxaliplatin-containing chemotherapy regimens indicated
that 24 patients (3.3%; 2 of the 24 had lung metastases) were able to It is important to note that some of the treatment approaches for patients
undergo curative resection after treatment.599 The median OS time in this diagnosed with rectal cancer and synchronous lung or liver metastases
group was 42.4 months. differ relative to those for patients diagnosed with similarly staged colon
cancer. In particular, initial treatment options for synchronous resectable
In addition, first-line FOLFOXIRI (infusional 5-FU, LV, oxaliplatin, rectal cancer include preoperative chemoRT directed toward treatment of
irinotecan) has been compared with FOLFIRI (infusional 5-FU, LV, the primary cancer; a preoperative chemotherapy regimen to target
irinotecan) in two randomized clinical trials in patients with unresectable metastatic disease; and a surgical approach (ie, staged or synchronous
disease.600,601 In both studies, FOLFOXIRI led to an increase in R0 resection of metastases and rectal lesion). Advantages of an initial
secondary resection rates: 6% versus 15%, P = .033 in the Gruppo chemoRT approach include a possible decreased risk of pelvic recurrence
Oncologico Nord Ovest (GONO) trial600; and 4% versus 10%, P = .08 in following surgery, while a disadvantage is that preoperative pelvic RT may
the Gastrointestinal Committee of the Hellenic Oncology Research Group decrease tolerance to systemic bevacizumab-containing adjuvant
(HORG) trial.601 In a follow-up study of the GONO trial, the 5-year survival regimens, thereby limiting subsequent treatment of systemic disease. Data
rate was higher in the group receiving FOLFOXIRI (15% vs. 8%), with a to guide decisions regarding optimal treatment approaches in this
median OS of 23.4 versus 16.7 months (P = .026).602 population of patients are very limited.

Chemotherapy regimens may be combined with bevacizumab or with Neoadjuvant Bevacizumab for Metastatic Disease
cetuximab or panitumumab for KRAS/NRAS/BRAF wild-type unresectable The efficacy of bevacizumab in combination with FOLFOX and FOLFIRI in
synchronous disease. In addition, checkpoint inhibitors may be considered the treatment of unresectable metastatic disease (see Systemic Therapy
for microsatellite instability-high (MSI-H)/deficient mismatch repair (dMMR) for Advanced or Metastatic Disease in the NCCN Guidelines for Colon
disease as an alternative to chemotherapy-containing regimens. See the Cancer) has led to a study of its use in combination with these regimens in
following sections for data supporting these treatment approaches. the preoperative setting. However, the safety of administering
bevacizumab preoperatively in combination with 5-FU–based regimens
When chemotherapy is planned for patients with initially unresectable has not been adequately evaluated. A retrospective evaluation of data
disease, the panel recommends that a surgical re-evaluation be planned 2 from two randomized clinical trials of 1132 patients receiving
months after initiation of chemotherapy, and that those patients who chemotherapy with or without bevacizumab as initial therapy for mCRC
continue to receive chemotherapy undergo surgical re-evaluation every 2 indicated that the incidence of wound healing complications was increased
months thereafter.597,603-605 Reported risks associated with chemotherapy for the group of patients undergoing a major surgical procedure while
include the potential for development of liver sinusoidal dilatation, receiving a bevacizumab-containing regimen when compared to the group
steatosis, or steatohepatitis.593,598,606 To limit the development of receiving chemotherapy alone while undergoing major surgery (13% vs.

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3.4%, respectively; P = .28).607 However, when chemotherapy plus The role of bevacizumab in the patient with unresectable mCRC, whose
bevacizumab or chemotherapy alone was administered prior to surgery, disease is felt to be potentially convertible to resectability with a reduction
the incidence of wound healing complications in either group of patients in tumor size, has also been studied. Data seem to suggest that
was low (1.3% vs. 0.5%; P = .63). The randomized phase III HEPATICA bevacizumab modestly improves the response rate to irinotecan-based
trial, which closed prematurely due to poor accrual, found that global regimens.614 As such, when an irinotecan-based regimen is selected for an
quality-of-life scores were higher in patients receiving CAPEOX plus attempt to convert unresectable disease to resectability, the use of
bevacizumab than those receiving CAPEOX alone after resection of liver bevacizumab would seem to be an appropriate consideration. The data on
metastases, but no conclusions could be drawn regarding the primary use of bevacizumab with oxaliplatin-based therapy in the conversion to
endpoint of DFS.608 resectability are mixed. On one hand, a 1400-patient, randomized, double-
blind, placebo-controlled trial of CAPEOX or FOLFOX with or without
A meta-analysis of RCTs published in 2011 demonstrated that the addition bevacizumab showed no benefit in terms of response rate or tumor
of bevacizumab to chemotherapy was associated with a higher incidence regression for the addition of bevacizumab, as measured by both
of treatment-related mortality than chemotherapy alone (RR, 1.33; 95% CI, investigators and an independent radiology review committee.615 On the
1.02–1.73; P = .04); hemorrhage (23.5%), neutropenia (12.2%), and other hand, the randomized BECOME trial of 241 patients with initially
gastrointestinal perforation (7.1%) were the most common causes of unresectable RAS mutant CRC liver metastases showed improvement in
fatality.609 Venous thromboembolisms, however, were not increased in the resectability of liver metastases as well as response rates and survival
patients receiving bevacizumab with chemotherapy versus those receiving with mFOLFOX6 plus bevacizumab compared to mFOLFOX6 alone.616 R0
chemotherapy alone.610 Another meta-analysis showed that bevacizumab resection rates were 22.3% in the bevacizumab combo versus 5.8% with
was associated with a significantly higher risk of hypertension, mFOLFOX6 alone (P < .01). Because it is not known in advance whether
gastrointestinal hemorrhage, and perforation, although the overall risk for resectability will be achieved, the use of bevacizumab with oxaliplatin-
hemorrhage and perforation is quite low.611 The risk of stroke and other based therapy in this setting is acceptable.
arterial events is increased in patients receiving bevacizumab, especially
in those aged 65 years or older. Gastrointestinal perforation is a rare but A pooled analysis of the phase III TRIBE and TRIBE2 studies compared
important side effect of bevacizumab therapy in patients with CRC.607,612 upfront FOLFOXIRI plus bevacizumab to chemotherapy doublets
Extensive prior intra-abdominal surgery, such as peritoneal stripping, may (FOLFOX or FOLFIRI) plus bevacizumab for oligometastatic mCRC.617 In
predispose patients to gastrointestinal perforation. The U.S. Food and agreement with the primary outcomes from these studies, the benefits of
Drug Administration (FDA) approved a safety label warning of the risk for using the chemotherapy triplet compared to the doublet were retained in
necrotizing fasciitis, sometimes fatal and usually secondary to wound the patient population that had oligometastatic disease, with interaction P
healing complications, gastrointestinal perforation, or fistula formation after scores above significance for PFS, OS, and ORR outcome measures.
bevacizumab use.613 Therefore, the authors of this study conclude that FOLFOXIRI provides a
benefit for oligometastatic CRC, including when used as upfront treatment
in conjunction with locoregional treatments, such as resection.

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Furthermore, an analysis of individual patient data from five trials that cetuximab arm and 7.4% in the control arm (P < .01). In addition, surgery
compared upfront FOLFOXIRI plus bevacizumab to doublet chemotherapy improved the median survival time compared to unresected participants in
plus bevacizumab reported a higher R0 resection rate in the FOLFOXIRI both arms, with longer survival in patients receiving cetuximab (46.4 vs.
arm.618 25.7 months; P = .007 for the cetuximab arm and 36.0 vs. 19.6 months; P
= .016 for the control arm).
The panel recommends against the use of bevacizumab as neoadjuvant
treatment of patients with resectable metastatic rectal cancer. For patients The randomized, phase II VOLFI trial compared the efficacy and safety of
who receive bevacizumab for unresectable disease and are converted to a mFOLFOXIRI in combination with panitumumab to FOLFOXIRI alone in
resectable state, the panel recommends at least a 6-week interval (which patients with RAS wild-type, primarily non-resectable mCRC.622 Of the
corresponds to two half-lives of the drug613) between the last dose of cohort with unresectable, potentially convertible metastases, 75% were
bevacizumab and surgery. Re-initiation of bevacizumab should be delayed ultimately converted to resectable with FOLFOXIRI + panitumumab
at least 6 to 8 weeks postoperatively. compared to 36.4% with FOLFOXIRI alone. ORR was also improved in
the combination compared to FOLFOXIRI alone while PFS was similar
Neoadjuvant Cetuximab and Panitumumab for Metastatic Disease between the two treatments and OS showed a trend in favor of the
More recent favorable results of randomized clinical trials evaluating combination. A recent meta-analysis of four RCTs concluded that the
FOLFIRI, FOLFOX, or FOLFOXIRI in combination with anti-epidermal addition of cetuximab or panitumumab to chemotherapy significantly
growth factor receptor (EGFR) inhibitors for the purpose of conversion of increased the response rate, the R0 resection rate (from 11%–18%; RR,
unresectable disease to resectable disease have been reported. For 1.59; P = .04), and PFS, but not OS in patients with wild-type KRAS exon
instance, in the CELIM phase II trial, patients were randomized to receive 2-containing tumors.623
cetuximab with either FOLFOX6 or FOLFIRI.619 Retrospective analysis
showed that in both treatment arms combined resectability increased from The randomized, phase III TRIPLETE study compared mFOLFOXIRI plus
32% to 60% after chemotherapy in patients with wild-type KRAS exon 2 panitumumab to mFOLFOX6 plus panitumumab as initial therapy for 435
with the addition of cetuximab (P < .0001). Final analysis of this trial patients with unresectable RAS and BRAF wild-type mCRC.624,625 This trial
showed that the median OS of the entire cohort was 35.7 months (95% CI, found that intensification of the chemotherapy regimen did not provide
27.2–44.2 months), with no difference between the arms.620 Another additional benefit when combined with panitumumab and led to higher
recent RCT compared chemotherapy (mFOLFOX6 or FOLFIRI) plus rates of gastrointestinal (GI) toxicity. Response rates (73% vs. 76%), early
cetuximab to chemotherapy alone in patients with unresectable CRC tumor shrinkage (57% vs. 58%), depth of response (48% vs. 47%), R0
metastatic to the liver.621 The primary endpoint was the rate of conversion resection rate (25% vs. 29%), and median PFS (12.7 vs. 12.3 months)
to resectability based on evaluation by a multidisciplinary team. After were similar between mFOLFOXIRI plus panitumumab and mFOLFOX
evaluation, 20 of 70 patients (29%) in the cetuximab arm and 9 of 68 plus panitumumab, respectively. Reflecting this data, the combination of
patients (13%) in the control arm were determined to be eligible for FOLFIRINOX with cetuximab or panitumumab is a category 2B
curative-intent hepatic resection. R0 resection rates were 25.7% in the recommendation for unresectable synchronous liver or lung only

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metastases, while the FOLFIRI or FOLFOX combinations are category 2A metastases.630 Additional recent meta-analyses have also shown no
recommendations within the same setting. statistically significant OS benefit with the addition of adjuvant
chemotherapy in resectable mCRC.631-633
Neoadjuvant Checkpoint Inhibitors for Metastatic Disease
While there are a lack of data in this setting, the panel considers The choice of chemotherapy regimen in the perioperative setting depends
pembrolizumab or nivolumab, as a monotherapy or in combination with on several factors, including the chemotherapy history of the patient and
ipilimumab, as options for neoadjuvant therapy of dMMR/MSI-H mCRC. the response rates and safety/toxicity issues associated with the
While there are no clinical trial data supporting this approach, a few case regimens, as outlined in the guidelines. Biologics are not recommended in
studies have reported notable responses to pembrolizumab and the perioperative setting for metachronous metastases, with the exception
nivolumab when used as a neoadjuvant therapy for dMMR advanced or of initial therapy in patients with unresectable metastatic disease that may
mCRC.626-628 The panel notes that special caution should be taken to be converted to a resectable state.
monitor for signs of progression, which could potentially cause a
previously resectable tumor to become unresectable. While this is a Although the benefits of perioperative chemotherapy for patients with liver
concern for any regimen being used as neoadjuvant therapy in the metastases have not yet been fully validated in randomized clinical trials,
resectable mCRC setting, the risk is possibly higher with immunotherapy the EORTC phase III study (EORTC 40983) evaluating use of
compared to traditional chemotherapy options. perioperative FOLFOX (six cycles before and six cycles after surgery) for
patients with initially resectable liver metastases demonstrated absolute
Perioperative Therapy for Resectable Metachronous Metastatic improvements in 3-year PFS of 8.1% (P = .041) and 9.2% (P = .025) for all
Disease eligible patients and all resected patients, respectively, when
Perioperative administration of chemotherapy is recommended for most chemotherapy in conjunction with surgery was compared with surgery
patients undergoing liver or lung resection for metachronous metastases alone.634 The partial response rate after preoperative FOLFOX was 40%,
with the goal of increasing the likelihood that residual microscopic disease and operative mortality was <1% in both treatment groups. However, no
will be eradicated. A meta-analysis identified three randomized clinical difference in OS was seen between the groups, perhaps because second-
trials comparing surgery alone to surgery plus systemic therapy with 642 line therapy was given to 77% of the patients in the surgery only arm and
evaluable patients with colorectal liver metastases.629 The pooled analysis to 59% of the patients in the chemotherapy arm.635 Furthermore, a multi-
showed a benefit of chemotherapy in PFS (pooled HR, 0.75; CI, 0.62– institutional phase II study investigating the feasibility and efficacy of
0.91; P = .003) and DFS (pooled HR, 0.71; CI, 0.58–0.88; P = .001), but preoperative mFOLFOX6 for patients with resectable liver metastases
not in OS (pooled HR, 0.74; CI, 0.53–1.05; P = .088). Another meta- demonstrated the feasibility of this approach.636 Three-year OS and PFS
analysis published in 2015 combined data on 1896 patients from 10 rates were 81.9% and 47.4%, respectively.
studies and also found that perioperative chemotherapy improved DFS
(HR, 0.81; 95% CI, 0.72–0.91; P = .0007) but not OS (HR, 0.88; 95% CI, The New EPOC trial, which was stopped early because it met protocol-
0.77–1.01; P = .07) in patients with resectable colorectal liver defined futility criteria, found a lack of benefit to cetuximab with
chemotherapy in the perioperative metastatic setting (>85% received

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FOLFOX or CAPEOX; patients with prior oxaliplatin received medical oncologists, radiologists, surgeons, and patients so that a
FOLFIRI).637,638 In fact, with less than half of expected events observed, treatment strategy can be developed that optimizes exposure to the
PFS was significantly reduced in the cetuximab arm (14.8 vs. 24.2 preoperative regimen and facilitates an appropriately timed surgical
months; HR 1.50; 95% CI, 1.00–2.25; P < .048) and longer-term follow-up intervention.593
confirmed these results with shorter median PFS (15.5 vs. 22.2 months)
and median OS (55.4 vs. 81.0 months) with addition of cetuximab to Other reported risks associated with the preoperative therapy approach
chemotherapy. The panel thus recommends against panitumumab and include the potential for development of liver steatohepatitis and sinusoidal
cetuximab as perioperative treatment for resectable metachronous liver injury when irinotecan- and oxaliplatin-based chemotherapeutic
metastatic disease. The panel also notes that cetuximab and regimens are administered, respectively.593-597 To reduce the development
panitumumab should be used with caution in patients with unresectable of hepatotoxicity, the neoadjuvant period is usually limited to 2 to 3
disease that could potentially be converted to a resectable status. months, and patients should be carefully monitored by a multidisciplinary
team.
The optimal sequencing of systemic therapy and resection remains
unclear. Patients with resectable disease may undergo resection first, Systemic Therapy for Advanced or Metastatic Disease
followed by postoperative adjuvant chemotherapy. Alternatively, The current management of disseminated mCRC involves various active
perioperative (neoadjuvant plus postoperative) systemic therapy can be drugs, either in combination or as single agents. The choice of therapy is
used.631,639 based on consideration of the goals of therapy, the type and timing of prior
therapy, the mutational profile of the tumor, and the differing toxicity
Potential advantages of preoperative therapy include: earlier treatment of profiles of the constituent drugs. Although the specific regimens listed in
micrometastatic disease, determination of responsiveness to therapy the guideline are designated according to whether they pertain to initial
(which can be prognostic and help in planning postoperative therapy), and therapy, therapy after first progression, or therapy after second
avoidance of local therapy for those patients with early disease progression, it is important to clarify that these recommendations
progression. Potential disadvantages include missing the “window of represent a continuum of care and that these lines of treatment are blurred
opportunity” for resection because of the possibility of disease progression rather than discrete.644 For example, if oxaliplatin is administered as part of
or achievement of a complete response, thereby making it difficult to an initial treatment regimen but is discontinued after 12 weeks or earlier
identify areas for resection.461,640,641 In fact, results from recent studies of for escalating neurotoxicity, continuation of the remainder of the treatment
patients with CRC receiving preoperative therapy indicated that viable regimen would still be considered initial therapy.
cancer was still present in most of the original sites of metastases when
these sites were examined pathologically despite achievement of a Principles to consider at the start of therapy include: 1) preplanned
complete response as evaluated on CT scan.641-643 Therefore, during strategies for altering therapy for patients exhibiting a tumor response or
treatment with preoperative systemic therapy, frequent evaluations must disease characterized as stable or progressive; and 2) plans for adjusting
be undertaken and close communication must be maintained among therapy for patients who experience certain toxicities. For example,

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NCCN Guidelines Version 4.2024

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decisions related to therapeutic choices after first progression of disease Recommendations for Treatment of Resectable Synchronous
should be based, in part, on the prior therapies received (ie, exposing the Metastases
patient to a range of cytotoxic agents). Furthermore, an evaluation of the When patients present with rectal cancer and synchronous liver- or lung-
efficacy and safety of these regimens for a patient must consider not only only metastases, the panel now recommends a TNT approach, with
the component drugs, but also the doses, schedules, and methods of choice of preoperative therapy based on the predicted status of the CRM
administration of these agents, and the potential for surgical cure as well by MRI. Upfront systemic treatment has the goal of early eradication of
as the patient’s quality of life. micrometastases, whereas the goal of short-course RT or long-course
chemoRT is local control of disease prior to surgery/local therapy. Those
The continuum of care approach to the management of metastatic rectal
with a predicted clear CRM should receive systemic therapy as described
cancer is the same as described for metastatic colon cancer. Please refer
in the guidelines followed by short-course RT (preferred) or long-course
to Systemic Therapy for Advanced or Metastatic Disease in the NCCN
chemoRT. Those with a CRM predicted to be involved can receive 1)
Guidelines for Colon Cancer for a detailed discussion of the various systemic therapy followed by long-course chemoRT; or 2) short-course RT
options for systemic treatment. The roles of biomarkers for treatment or long-course chemoRT followed by systemic therapy. Restaging should
selection in the advanced and metastatic disease setting are also be performed before resection.
discussed.
Biomarkers for Systemic Therapy There is NCCN Member Institutional variation in the choice of neoadjuvant
As the role of targeted therapy for treatment of advanced CRC or mCRC therapy approach for resectable synchronous metastases. Standard
has become increasingly prominent, the NCCN Panel has expanded its practice at some institutions is to start with chemotherapy and then to
recommendations regarding biomarker testing. Currently, determination of stratify further treatment based on the degree of metastatic disease and
tumor gene status for KRAS/NRAS and BRAF mutations, as well as HER2 the response to initial therapy. If the risk of distant progression is deemed
amplifications and MSI/MMR status (if not previously done), are to be the greater concern, resection would be the next course of
recommended for patients with mCRC. Testing may be carried out for treatment. If local progression appears more likely, then RT would be
individual genes or as part of a tissue- or blood-based next-generation given before surgery.
sequencing (NGS) panel, although no specific methodology is
Resection of the primary tumor and liver can be done in a simultaneous or
recommended. NGS panels have the advantage of being able to pick up
staged approach following neoadjuvant treatment.645-652 Historically, in the
rare and actionable genetic alterations, such as neurotrophic tyrosine
staged approach, the primary tumor was usually resected first. However,
receptor kinase (NTRK) fusions. Discussion about each of these
the approach of liver resection before resection of the primary tumor is
biomarkers may be found in the Biomarkers for Systemic Therapy section
now well-accepted. In addition, emerging data suggest that chemotherapy,
of the NCCN Guidelines for Colon Cancer.
followed by resection of liver metastases before resection of the primary
tumor, might be an effective approach in some patients, although more
studies are needed.653-655 In addition, neoadjuvant short-course radiation

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of T1–T3 primary rectal tumors is an option in this setting.656 Locally retrospective analyses have also shown a potential benefit.658-664 Separate
ablative procedures can be considered instead of or in addition to analyses of the SEER database and the National Cancer Database also
resection in cases of liver or lung oligometastases (see Local Therapies identified a survival benefit of primary tumor resection in this setting.665,666
for Metastases, above), but resection is preferred.
However, a different analysis of the National Cancer Database came to
The panel acknowledges that some patients may not be candidates for the opposite conclusion.667 The randomized phase III JCOG1007 study
systemic therapy or radiation; clinical judgment should be used in such also concluded that primary tumor resection followed by chemotherapy in
cases. patients with synchronous unresectable metastases conferred no survival
benefit over chemotherapy alone.668 For the 165 patients enrolled in this
Recommendations for Treatment of Unresectable Synchronous study, median OS was 25.9 months with primary tumor resection plus
Metastases
chemotherapy compared to 26.7 months for chemotherapy alone. Median
Patients with unresectable synchronous liver- or lung-only metastases or PFS was 10.4 and 12.1 months, respectively. Three patients in this study
who are medically inoperable are treated with intensive systemic therapy died following primary tumor resection due to postoperative complications.
for advanced or metastatic disease to attempt to render these patients Furthermore, the prospective, multicenter, phase II NSABP C-10 trial
candidates for disease resection (see Determining Resectability and showed that patients with an asymptomatic primary colon tumor and
Neoadjuvant Therapy and Conversion to Resectability, above). unresectable metastatic disease who received mFOLFOX6 with
Chemotherapy regimens with high response rates should be considered bevacizumab experienced an acceptable level of morbidity without upfront
for patients with potentially convertible disease.657 These patients should resection of the primary tumor.669 The median OS was 19.9 months.
be re-evaluated for resection after 2 months of chemotherapy and every 2 Notably, symptomatic improvement in the primary is often seen with
months thereafter while undergoing such therapy. Patients who become systemic chemotherapy even within the first 1 to 2 weeks.
resectable should receive short-course RT (preferred) or long-course
chemoRT followed by immediate or delayed staged or synchronous Complications from the intact primary lesion are uncommon in this
resection and/or local therapy for metastases and resection of the rectal setting,498 and its removal delays initiation of systemic therapy. In fact, a
lesion. Patients with disease that remains unresectable after initial systematic review concluded that resection of the primary tumor does not
systemic therapy should proceed to second-line systemic therapy for reduce complications and does not improve OS.670 Another systematic
advanced or metastatic disease and local therapy may be considered for review and meta-analysis identified five studies that compared open to
select patients. Palliative RT or chemoRT can be given prior to second- laparoscopic palliative colectomies in this setting.671 The laparoscopic
line therapy if progression of the primary tumor occurred during first-line approach resulted in shorter lengths of hospital stays (P < .001), fewer
treatment. postoperative complications (P = .01), and lower estimated blood loss (P <
.01).
Results from one study suggest that there may be some benefit in both
OS and PFS from resection of the primary tumor in the setting of Overall, the panel believes that the risks of surgery outweigh the possible
unresectable colorectal metastases.658 Other systematic reviews and benefits of resection of asymptomatic primary tumors in the setting of

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unresectable colorectal metastases. Routine palliative resection of a additional metastatic disease was identified (bone, peritoneum/omentum,
synchronous primary lesion should therefore only be considered if the and abdominal nodes). In addition, 1.5% of patients had more extensive
patient has an unequivocal imminent risk of obstruction, acute significant hepatic resections and 3.4% had additional organ surgery. An additional
bleeding, perforation, or other significant tumor-related symptoms. 8.4% of patients in the PET/CT arm had false-positive results, many of
which were investigated with biopsies or additional imaging. A meta-
An intact primary tumor is not a contraindication to bevacizumab use. The analysis of 18 studies including 1059 patients with hepatic colorectal
risk of gastrointestinal perforation in the setting of bevacizumab is not metastases found that PET or PET/CT results changed management in
decreased by removal of the primary tumor, because large bowel 24% of patients.676
perforations, in general, and perforation of the primary lesion, in particular,
are rare (see Systemic Therapy for Advanced or Metastatic Disease in the As with other conditions in which stage IV disease is diagnosed, a tumor
Discussion section of the NCCN Guidelines for Colon Cancer). analysis (metastases or original primary) for KRAS/NRAS and BRAF
mutations and HER2 amplifications, as well as MSI/MMR testing if not
Recommendations for Treatment of Metachronous Metastases previously done, should be performed (see Neoadjuvant Cetuximab and
In a single-institution, retrospective analysis of 735 patients with stage II/III Panitumumab for Metastatic Disease, above). Close communication
rectal cancer treated with preoperative chemoRT followed by TME, the 5- between members of the multidisciplinary treatment team is
year rates of liver and lung recurrences were 6.3% and 10.2%, recommended, including upfront evaluation by a surgeon experienced in
respectively.672 Resection of liver- and lung-only recurrences resulted in the resection of hepatobiliary and lung metastases.
comparable survival (5.3 years and 5.1 years, respectively; P = .39).
The management of metachronous metastatic disease is distinguished
On documentation of metachronous, potentially resectable, metastatic from that of synchronous disease through also including an evaluation of
disease with dedicated contrast-enhanced CT or MRI, characterization of the chemotherapy history of the patient and through the absence of
the disease extent using PET/CT scan should be considered in select transabdominal resection. Patients with resectable disease are classified
cases if a surgical cure of M1 disease is feasible. PET/CT is used at this according to whether they have undergone previous chemotherapy. For
juncture to promptly characterize the extent of metastatic disease, and to patients who have resectable metastatic disease, treatment is resection
identify possible sites of extrahepatic disease that could preclude with up to 6 months of perioperative chemotherapy (pre- or postoperative
surgery.673,674 Specifically, Joyce et al reported that the preoperative PET or a combination of both), with choice of regimens based on previous
changed or precluded curative-intent liver resection in 25% of patients.673 therapy. Locally ablative procedures can be considered instead of or in
A recent randomized clinical trial of patients with resectable metachronous addition to resection in cases of liver or lung oligometastases (see Local
metastases also assessed the role of PET/CT in the workup of potential Therapies for Metastases, above), but resection is preferred. For patients
curable disease.675 While there was no impact of PET/CT on survival, without a history of chemotherapy use, FOLFOX or CAPEOX are
surgical management was changed in 8% of patients after PET/CT. For preferred, with capecitabine and 5-FU/LV as additional category 2B
example, resection was not undertaken for 2.7% of patients because options. There are also cases when perioperative chemotherapy is not

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NCCN Guidelines Version 4.2024

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recommended in resectable metachronous disease. In particular, patients treatment; and time to failure of strategy, which includes intervals between
with a history of previous chemotherapy and upfront resection can be treatment courses and ends when the planned lines of treatment end
observed or may be given an active regimen for advanced disease (because of death, progression, or administration of a new agent).679 The
(category 2B for the use of biologic agents in these settings). Observation authors found a better correlation between these endpoints and OS than
is preferred if oxaliplatin-based therapy was previously administered. between PFS and OS. Another alternative endpoint, time to tumor growth,
has also been suggested to predict OS.682,683 Further evaluation of these
Patients determined to have unresectable disease through cross-sectional and other surrogate endpoints is warranted.
imaging scan (including those considered potentially convertible) should
receive an active systemic therapy regimen based on prior chemotherapy Post-Treatment Surveillance
history (see Second-line or Subsequent Systemic Therapy in the After curative-intent surgery and adjuvant chemotherapy, if administered,
Discussion section of the NCCN Guidelines for Colon Cancer). In the case post-treatment surveillance of patients with CRC is performed to evaluate
of liver metastases only, HAIC with or without systemic 5-FU/LV (category for possible therapeutic complications, discover a recurrence that is
2B) is an option at centers with experience in the surgical and medical potentially resectable for cure, and identify new metachronous neoplasms
oncologic aspects of this procedure. Patients receiving palliative systemic at a preinvasive stage. An analysis of data from 20,898 patients enrolled in
therapy should be monitored with CT or MRI scans approximately every 2 18 large, adjuvant colon cancer, randomized trials showed that 80% of
to 3 months. recurrences occurred in the first 3 years after surgical resection of the
primary tumor,684 and a recent study found that 95% of recurrences
Endpoints for Advanced CRC Clinical Trials
occurred in the first 5 years.685
In the past few years, there has been much debate over what endpoints
are most appropriate for clinical trials in advanced CRC.677 Quality of life is Advantages of more intensive follow-up of patients after treatment of stage
an outcome that is rarely measured but is of unquestioned clinical II and/or stage III disease have been demonstrated prospectively in
relevance.678 While OS is also of clear clinical relevance, it is often not several older studies686-688 and in multiple meta-analyses of RCTs
used because large numbers of patients and long follow-up periods are designed to compare low-intensity and high-intensity programs of
required.678 PFS is often used as a surrogate, but its correlation with OS is surveillance.689-693 In the final analysis of the Intergroup trial 0114
inconsistent at best, especially when subsequent lines of therapy are comparing bolus 5-FU to bolus 5-FU/LV in patients with surgically
administered.678-680 In 2011, the GRUPO Español Multidisciplinar en resectable rectal cancer, local recurrence rates continued to rise after 5
Cáncer Digestivo (GEMCAD) proposed particular aspects of clinical trial years.293 Further, a population-based report indicated that long-term
design to be incorporated into trials that use PFS as an endpoint.681 survival is possible in patients treated for local recurrence of rectal cancer
(overall 5-year relative survival rate of 15.6%), thereby providing support
A study, in which individual patient data from three RCTs were pooled, for more intensive post-treatment follow-up in these patients.694
tested endpoints that take into account subsequent lines of therapy:
duration of disease control, which is the sum of PFS times of each active

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Results from the randomized controlled FACS trial of 1202 patients with The randomized phase III PRODIGE 13 trial is comparing 5-year OS after
resected stage I to III disease showed that intensive surveillance imaging intensive radiologic monitoring (abdominal ultrasound,
or CEA screening resulted in an increased rate of curative-intent surgical chest/abdomen/pelvis CT, and CEA) with a lower intensity program
treatment compared with a minimum follow-up group that only received (abdominal ultrasound and chest x-ray) in patients with resected stage II
testing if symptoms occurred, but no advantage was seen in the CEA and or III colon or rectal tumors.700 An abstract reporting results from 1995
CT combination arm (2.3% in the minimum follow-up group, 6.7% in the patients on this trial concluded that the more intensive surveillance
CEA group, 8% in the CT group, and 6.6% in the CEA plus CT group).695 program did not provide any benefit in 5-year OS, but did result in more
In this study, no mortality benefit to regular monitoring with CEA, CT, or curative intent secondary surgeries for colon cancer. Surgical treatment of
both was observed compared with minimum follow-up (death rate, 18.2% recurrence was performed in 40.9% of patients receiving minimal
vs. 15.9%; difference, 2.3%; 95% CI, -2.6% to 7.1%). The authors surveillance (no CT, no CEA), 66.3% of patients receiving lower intensity
concluded that any strategy of surveillance is unlikely to provide a large imaging plus CEA, 50.7% of patients receiving no CEA but higher intensity
survival advantage over a symptom-based approach.695 The randomized imaging, and 59.5% in the maximum surveillance group with both CEA
COLOFOL trial of 2509 patients with stage II or III CRC looked at follow-up and CT (P = .0035).701
testing with CT of the thorax and abdomen and CEA screening, comparing
a high-frequency surveillance approach (CT and CEA at 6, 12, 18, 24, and Meta-analyses support the conclusion that more intensive surveillance of
36 months post-surgery) to a low-frequency approach (CT and CEA at 12 patients with resected CRC results in earlier detection of recurrences,
and 36 months post-surgery).696 This trial reported no significant difference without any effect on survival.690,691
in 5-year overall mortality or CRC-specific mortality between the two
Patients who had resection of mCRC can undergo subsequent curative-
screening approaches.
intent resection of recurrent disease (see Surgical Management of
The CEAwatch trial compared usual follow-up care to CEA measurements Colorectal Metastases, above), and therefore should undergo post-
every 2 months, with imaging performed if CEA increases were seen treatment surveillance. A retrospective analysis of 952 patients who
twice, in 3223 patients treated for non-mCRC at 11 hospitals in the underwent resection at Memorial Sloan Kettering Cancer Center showed
Netherlands.697 The intensive CEA surveillance protocol resulted in the that 27% of patients with recurrent disease underwent curative-intent
detection of more total recurrences and recurrences that could be treated resection and that 25% of those patients (6% of recurrences; 4% of the
with curative intent than usual follow-up, and the time to detection of initial population) were free of disease for greater than or equal to 36
recurrent disease was shorter. However, no OS or disease-specific months.702
survival benefit was seen.698 Another randomized trial of 1228 patients
Controversies remain regarding selection of optimal strategies for
found that more intensive surveillance led to earlier detection of
following patients after potentially curative CRC surgery, and the panel’s
recurrences than a less intensive program (less frequent colonoscopy and
recommendations are based mainly on consensus. The panel endorses
liver ultrasound and the absence of an annual chest x-ray) but also did not
surveillance as a means to identify patients who are potentially curable of
affect OS.699
metastatic disease with surgical resection.

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The panel recommendations for post-treatment surveillance pertain to for a total of 5 years; and a CEA test (also see Managing an Increasing
patients who have undergone successful treatment (ie, no known residual CEA Level, below) is recommended at baseline and every 3 to 6 months
disease) and are separated into three groups: 1) those who received for 2 years,706 then every 6 months for a total of 5 years for patients with
transanal local excision only; 2) patients with stage I disease and full stage III disease and those with stage II disease if the clinician determines
surgical staging; and 3) patients with stage II–IV disease. that the patient is a potential candidate for aggressive curative
surgery.689,706,707 Chest, abdominal, and pelvic CT scans are
For all three groups, colonoscopy is recommended at approximately 1 recommended every 3 to 6 months for 2 years and then every 6 to 12
year following resection (or at approximately 3 to 6 months post-resection months for up to 5 years.689,708 CT scan is recommended to monitor for the
if not performed preoperatively due to an obstructing lesion). Repeat presence of potentially resectable metastatic lesions, primarily in the lung
colonoscopy is typically recommended at 3 years, and then every 5 years and the liver. Hence, CT scan is not routinely recommended in patients
thereafter, unless follow-up colonoscopy indicates advanced adenoma who are not candidates for potentially curative resection of liver or lung
(villous polyp, polyp >1 cm, or high-grade dysplasia), in which case metastases. A recent analysis of patients with resected or ablated
colonoscopy should be repeated in 1 year.703 More frequent colonoscopies colorectal liver metastases found that the frequency of surveillance
may be indicated in patients who present with CRC before age 50.703 imaging did not correlate with time to second procedure or median survival
Surveillance colonoscopies are primarily aimed at identifying and duration.709 Those scanned once per year survived a median of 54 months
removing metachronous polyps since data show that patients with a versus 43 months for those scanned three to four times per year (P = .08),
history of CRC have an increased risk of developing second cancers,704 suggesting that annual scans may be sufficient in this population.
particularly in the first 2 years following resection. The use of post-
treatment surveillance colonoscopy has not been shown to improve Routine CEA monitoring and CT scanning are not recommended beyond 5
survival through the early detection of recurrence of the original CRC.703 years. In addition, use of PET/CT to monitor for disease recurrence is not
recommended.708,710 The CT that accompanies a PET/CT is usually a
Proctoscopy with EUS or MRI is recommended to evaluate the rectal noncontrast CT, and therefore is not of ideal quality for routine
anastomosis for local recurrence in patients treated with transanal local surveillance.
excision only. Proctoscopy is not recommended for other patients,
because isolated local recurrences are rarely found in these patients and The American Society of Clinical Oncology (ASCO) Clinical Practice
are rarely curable. In fact, in a single-center study of 112 patients who had Guidelines Committee has endorsed the Follow-up Care, Surveillance
TME for rectal cancer, only one local recurrence occurred, and it was not Protocol, and Secondary Prevention Measures for Survivors of Colorectal
identified by rectal surveillance but by CEA and symptoms.705 In these 112 Cancer, from Cancer Care Ontario (CCO).711,712 These guidelines differ
patients, 20 anoscopies, 44 proctoscopies, and 495 flexible only slightly from the surveillance recommendations in these NCCN
sigmoidoscopies were performed. Guidelines for Rectal Cancer. While ASCO/CCO recommend abdominal
and chest CT annually for 3 years, the NCCN Panel recommends semi-
For the stage II–IV group, history and physical examination is annual to annual scans for 5 years (category 2B for more frequent than
recommended every 3 to 6 months for 2 years, and then every 6 months

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NCCN Guidelines Version 4.2024

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annual scanning). The panel bases its recommendation on the fact that A PET/CT scan may be considered in the scenario of an elevated CEA
approximately 10% of disease recurrences occur after 3 years.685,713 The with negative, good-quality CT scans. A systematic review and meta-
American Society of Colon and Rectal Surgeons also released analysis found 11 studies (510 patients) that addressed the use of PET/CT
surveillance guidelines, which are also very similar to NCCN surveillance in this setting.718 The pooled estimates of sensitivity and specificity for the
recommendations.714 One exception is the inclusion of intensive detection of tumor recurrence were 94.1% (95% CI, 89.4%–97.1%) and
surveillance for patients with resected stage I colon or rectal cancer if the 77.2% (95% CI, 66.4%–85.9%), respectively. An analysis of outcomes of
provider deems the patient to be at increased risk for recurrence. 88 patients treated for CRC under surveillance who had normal or
equivocal conventional imaging results with an elevated CEA found that
All patients with rectal cancer should be counseled for family history. For PET/CT had a sensitivity of 88% and a specificity of 88% for the detection
patients with suspected Lynch syndrome, FAP, or attenuated FAP, see the of recurrences.719
NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal.
The panel does not recommend a so-called blind or CEA-directed
Managing an Increasing CEA Level laparotomy or laparoscopy for patients whose workup for an increased
Management of an elevated CEA level after resection should include CEA level is negative,720 nor do they recommend use of anti-CEA–
colonoscopy; chest, abdominal, and pelvic CT scans; physical radiolabeled scintigraphy.
examination; and consideration of a PET/CT scan. If imaging study results
are normal in the face of a rising CEA, repeat CT scans are recommended Treatment of Locally Recurrent Disease
every 3 months until either disease is identified or CEA level stabilizes or Locally recurrent rectal cancer is characterized by isolated
declines. pelvic/anastomotic recurrence of disease. In a single-center study, Yu et al
reported low rates of 5-year local recurrence (ie, 5-year locoregional
In a recent retrospective chart review at Memorial Sloan Kettering Cancer
control rate of 91%) for patients with rectal cancer treated with surgery and
Center, approximately half of elevations in CEA levels after R0 resection
either RT or chemoRT, and 49% of recurrences occurred in the low pelvic
of locoregional CRC were false positives, with most being single high
and presacral regions with an additional 14% occurring in the mid and high
readings or repeat readings in the range of 5 to 15 ng/mL.715 In this study,
pelvis.721 In a more recent, single-institution, retrospective analysis of 735
false-positive results greater than 15 ng/mL were rare, and all results
patients with stage II/III rectal cancer treated with preoperative chemoRT
greater than 35 ng/mL represented true positives. Following a systematic followed by TME, locoregional recurrence rate at 5 years was 4.6%,
review and meta-analysis, the pooled sensitivity and specificity of CEA at occurring at a median of 24.7 months.672
a cutoff of 10 ng/mL were calculated at 68% (95% CI, 53%–79%) and 97%
(95% CI, 90%–99%), respectively.716,717 In the first 2 years post-resection, The panel recommends that patients with unresectable lesions be treated
a CEA cutoff of 10 ng/mL is estimated to detect 20 recurrences, miss 10 with systemic therapy, chemoRT, or short-course RT according to their
recurrences, and result in 29 false positives. ability to tolerate therapy. Debulking that results in gross residual cancer is
not recommended. Potentially resectable isolated pelvic/anastomotic

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NCCN Guidelines Version 4.2024

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recurrence may be managed with neoadjuvant therapy, including sequelae of treatment should be described. Finally, surveillance and
chemotherapy before or after chemoRT or short-course RT, followed by health behavior recommendations should be part of the care plan.
resection. When following this approach, starting neoadjuvant therapy with
chemotherapy is preferred. IORT or brachytherapy should be considered Disease preventive measures, such as immunizations; early disease
with resection if it can be safely delivered.453,722-724 Alternatively, resection detection through periodic screening for second primary cancers (eg,
may be done first, followed by adjuvant chemoRT. breast, cervical, or prostate cancers); and routine good medical care and
monitoring are recommended (see the NCCN Guidelines for Survivorship).
A retrospective study found that re-resection was not associated with Additional health monitoring should be performed as indicated under the
improved survival in patients with isolated locoregional recurrence (3.6 care of a primary care physician. Survivors are encouraged to maintain a
years with surgery vs. 3.2 years without surgery; P = .353).672 Older therapeutic relationship with a primary care physician throughout their
studies have shown that patients with disease recurrence at the lifetime.732
anastomotic site are more likely to be cured following re-resection than
those with an isolated pelvic recurrence.725,726 In a study of 43 consecutive Other recommendations include monitoring for late sequelae of rectal
patients with advanced pelvic recurrence of CRC who had not undergone cancer or of the treatment of rectal cancer, such as bowel function
prior RT, treatment with 5 weeks of 5-FU by infusion concurrent with RT changes (eg, patients with stoma).733-738 Urogenital dysfunction following
enabled the majority of patients (77%) to undergo re-resection with resection and/or pelvic irradiation is common.733,739-741 Patients should be
curative intent.726 Studies of patients who previously received pelvic screened for sexual dysfunction, erectile dysfunction, dyspareunia, vaginal
radiation show that re-irradiation can be effective, with acceptable rates of dryness, and urinary incontinence, frequency, and urgency. Referral to a
toxicity.727-730 In one such study of 48 patients with recurrent rectal cancer gynecologist or urologist can be considered for persistent symptoms.
and a history of pelvic radiation, the 3-year rate of grade 3–4 late toxicity Other long-term problems common to CRC survivors include oxaliplatin-
was 35%, and 36% of patients treated were able to undergo surgery induced peripheral neuropathy, fatigue, insomnia, cognitive dysfunction,
following radiation.727 IMRT can be used in this setting of re-irradiation. and emotional or social distress.742-747 Specific management interventions
to address side effects of CRC have been described,748 and a survivorship
Survivorship care plan for patients with CRC has been published.749
The panel recommends that a prescription for survivorship and transfer of
The NCCN Guidelines for Survivorship provide screening, evaluation, and
care to the primary care physician be written.731 The oncologist and
treatment recommendations for common consequences of cancer and
primary care provider should have defined roles in the surveillance period,
cancer treatment to aid health care professionals who work with survivors
with roles communicated to the patient. The care plan should include an of adult-onset cancer in the post-treatment period, including those in
overall summary of treatments received, including surgeries, radiation
specialty cancer survivor clinics and primary care practices. These
treatments, and chemotherapy. The possible expected time to resolution
guidelines include many topics with potential relevance to survivors of
of acute toxicities, long-term effects of treatment, and possible late
CRC, including anxiety, depression, and distress; cognitive dysfunction;
fatigue; pain; sexual dysfunction; healthy lifestyles; and immunizations.

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NCCN Guidelines Version 4.2024

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Concerns related to employment, insurance, and disability are also Recent analyses confirm the increased risk for recurrence and death in
discussed. The American Cancer Society (ACS) has also established patients affected by obesity.89 Data from the ACCENT database also
guidelines for the care of survivors of CRC, including surveillance for found that pre-diagnosis BMI has a prognostic impact on outcomes in
recurrence, screening for subsequent primary malignancies, the patients with stage II/III CRC undergoing adjuvant therapy.759 However, a
management of physical and psychosocial effects of cancer and its recent analysis of participants in the Cancer Prevention Study II Nutrition
treatment, and promotion of healthy lifestyles.732 Cohort who subsequently developed non-mCRC found that pre-diagnosis
obesity but not post-diagnosis obesity was associated with higher all-
Healthy Lifestyles for Survivors of CRC cause and CRC-specific mortality.760 A meta-analysis of prospective
Evidence indicates that certain lifestyle characteristics, such as smoking cohort studies found that pre-diagnosis obesity was associated with
cessation, maintaining a healthy BMI, engaging in regular exercise, and increased CRC-specific and all-cause mortality.761 Other analyses confirm
making certain dietary choices are associated with improved outcomes the increased risk for recurrence and death in patients affected by
and quality of life after treatment for CRC. In a prospective observational obesity.89,762-765
study of patients with stage III colon cancer enrolled in the CALGB 89803
adjuvant chemotherapy trial, DFS was found to be directly related to how In contrast, pooled data from first-line clinical trials in the ARCAD
much exercise these patients received.750 In addition, a recent study of a database indicate that a low BMI may be associated with an increased risk
large cohort of men treated for stage I–III CRC showed an association of progression and death in the metastatic setting, whereas a high BMI
between increased physical activity and lower rates of CRC-specific may not be.766 In addition, results of one retrospective observational study
mortality and overall mortality.751 More recent data support the conclusion of a cohort of 3408 patients with resected stage I–III CRC suggest that the
that physical activity improves outcomes. In a cohort of greater than 2000 relationship between mortality and BMI might be U shaped, with the lowest
survivors of non-mCRC, those who spent more time in recreational activity mortality for those with a BMI 28 kg/m2.767 However, several possible
had a lower mortality than those who spent more leisure time sitting.752 In explanations for this so-called “obesity paradox” have been suggested.768
addition, recent evidence suggests that both pre- and post-diagnosis Overall the panel believes that survivors of CRC should be encouraged to
physical activity decrease CRC mortality. Those enrolled in the Women's achieve and maintain a healthy body weight (see the NCCN Guidelines for
Health Initiative study who subsequently developed CRC had lower CRC- Survivorship).
specific mortality (HR, 0.68; 95% CI, 0.41–1.13) and all-cause mortality
A diet consisting of more fruits, vegetables, poultry, and fish, less red
(HR, 0.63; 95% CI, 0.42–0.96) if they reported high levels of physical
meat, more whole grains, and fewer refined grains and concentrated
activity.753 Similar results were seen in other studies and in recent meta-
sweets was found to be associated with an improved outcome in terms of
analyses of prospective studies.754-757
cancer recurrence or death.769 There is also some evidence that higher
A retrospective study of patients with stage II and III colon cancer enrolled postdiagnosis intake of total milk and calcium may be associated with a
in NSABP trials from 1989 to 1994 showed that patients with a BMI of 35 lower risk of death in patients with stage I, II, or III CRC.95 Recent analysis
kg/m2 or greater had an increased risk of disease recurrence and death.758 of the CALGB 89803 trial found that higher dietary glycemic load was also

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NCCN Guidelines Version 4.2024

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associated with an increased risk of recurrence and mortality in patients 95% CI, 0.68–0.85; P < .001) and cancer-specific survival (HR, 0.70; 95%
with stage III disease.770 Another analysis of the data from CALGB 89803 CI, 0.60–0.81; P < .001).776
found an association between high intake of sugar-sweetened beverages
and an increased risk of recurrence and death in patients with stage III Abundant data show that low-dose aspirin therapy after a diagnosis of
colon cancer.771 The link between red and processed meats and mortality CRC decreases the risk of recurrence and death.778-784 For example, a
in survivors of non-mCRC has been further supported by recent data from population-based, observational, retrospective cohort study of 23,162
the Cancer Prevention Study II Nutrition Cohort, in which survivors with patients with CRC in Norway found that post-diagnosis aspirin use was
consistently high intake had a higher risk of CRC-specific mortality than associated with improved CRC-specific survival (HR, 0.85; 95% CI, 0.79–
those with low intake (RR, 1.79; 95% CI, 1.11–2.89).91 0.92) and OS (HR, 0.95; 95% CI, 0.90–1.01).778 Some evidence suggests
that tumor mutations in PIK3CA may be predictive of response to aspirin,
A discussion of lifestyle characteristics that may be associated with a although the data are somewhat inconsistent and other predictive markers
decreased risk of CRC recurrence, such as those recommended by the have also been suggested.780,785-790 In addition, a meta-analysis of 15
ACS,772 also provides “a teachable moment” for the promotion of overall RCTs showed that while non-aspirin NSAIDs were better for preventing
health, and an opportunity to encourage patients to make choices and recurrence, low-dose aspirin was safer and thereby had a more favorable
changes compatible with a healthy lifestyle. In addition, a recent trial risk-to-benefit profile.791
showed that telephone-based health behavior coaching had a positive
effect on physical activity, diet, and BMI in survivors of CRC, suggesting Based on these data, the panel believes that survivors of CRC can
that survivors may be open to health behavior change.773 consider taking 325 mg aspirin daily to reduce their risk of recurrence and
death. Importantly, aspirin may increase the risk of gastrointestinal
Therefore, survivors of CRC should be encouraged to maintain a healthy bleeding and hemorrhagic stroke, and these risks should be discussed
body weight throughout life; adopt a physically active lifestyle (at least 30 with CRC survivors.792
minutes of moderate-intensity activity on most days of the week); consume
a healthy diet with emphasis on plant sources; eliminate or limit alcohol Summary
consumption; and quit smoking.774 Activity recommendations may require The NCCN Rectal Cancer Panel believes that a multidisciplinary
modification based on treatment sequelae (ie, ostomy, neuropathy), and approach, including representation from gastroenterology, medical
diet recommendations may be modified based on the severity of bowel oncology, surgical oncology/colorectal surgery, radiation oncology, and
dysfunction.775 radiology is necessary for treating patients with rectal cancer. Adequate
pathologic assessment of the resected lymph nodes is important. Patients
Secondary Chemoprevention for CRC Survivors with very-early-stage tumors that are node-negative by endorectal
Limited data suggest a link between post-colorectal-cancer-diagnosis ultrasound or endorectal or pelvic MRI and who meet carefully defined
statin use and increased survival.112,776,777 A meta-analysis that included criteria can be managed with a transanal local excision. A transabdominal
four studies found that post-diagnosis statin use increased OS (HR, 0.76; resection is appropriate for other rectal lesions. A TNT approach

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consisting of chemoRT/short-course RT and chemotherapy is preferred for

the majority of patients with suspected or proven T3–4 disease and/or
regional node involvement.

The recommended post-treatment surveillance program for patients

following treatment for rectal cancer includes serial CEA determinations,
as well as periodic chest, abdominal, and pelvic CT scans, and periodic
evaluation by colonoscopy. Patients with recurrent localized disease
should be considered for resection with chemotherapy and radiation. If
resection is not possible, then systemic therapy, chemoRT, or RT alone
may be given.

A patient with metastatic disease in the liver or lung should be considered

for surgical resection if he or she is a candidate for surgery and if complete
resection (R0) can be achieved. Preoperative systemic therapy, and
sometimes chemoRT or short-course RT, are used in the synchronous
setting, and perioperative chemotherapy is used in the metachronous
setting.

Recommendations for patients with disseminated, unresectable metastatic

disease represent a continuum of care in which lines of treatment are
blurred rather than discrete. Principles to consider at the start of therapy
include pre-planned strategies for altering therapy for patients in both the
presence and absence of disease progression and plans for adjusting
therapy for patients who experience certain toxicities. Recommended
systemic therapy options for advanced or metastatic disease depend on
whether the patient is appropriate for intensive therapy; the biomarker
status of the tumor; and for patients with progressive disease, the choice
of initial therapy.

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Figure 1. Definition of Rectum

Used with permission of Mayo Foundation for Medical Education and Research. All rights reserved.

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9. Hemminki K, Eng C. Clinical genetic counselling for familial cancers

References requires reliable data on familial cancer risks and general action plans. J
1. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Med Genet 2004;41:801-807. Available at:
Cancer J Clin 2022;72:7-33. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15520403.
https://www.ncbi.nlm.nih.gov/pubmed/35020204.
10. Hemminki K, Chen B. Familial risk for colorectal cancers are mainly
2. Cheng L, Eng C, Nieman LZ, et al. Trends in colorectal cancer due to heritable causes. Cancer Epidemiol Biomarkers Prev
incidence by anatomic site and disease stage in the United States from 2004;13:1253-1256. Available at:
1976 to 2005. Am J Clin Oncol 2011;34:573-580. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15247139.
http://www.ncbi.nlm.nih.gov/pubmed/21217399.
11. Quintero E, Carrillo M, Leoz ML, et al. Risk of advanced neoplasia in
3. Siegel RL, Miller KD, Goding Sauer A, et al. Colorectal cancer statistics, first-degree relatives with colorectal cancer: a large multicenter cross-
2020. CA Cancer J Clin 2020;70:145-164. Available at: sectional study. PLoS Med 2016;13:e1002008. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/32133645. http://www.ncbi.nlm.nih.gov/pubmed/27138769.

4. Bailey CE, Hu CY, You YN, et al. Increasing disparities in the age- 12. Hampel H, Frankel WL, Martin E, et al. Feasibility of screening for
related incidences of colon and rectal cancers in the United States, 1975- Lynch syndrome among patients with colorectal cancer. J Clin Oncol
2010. JAMA Surg 2014:1-6. Available at: 2008;26:5783-5788. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/25372703. http://www.ncbi.nlm.nih.gov/pubmed/18809606.

5. Weinberg BA, Marshall JL, Salem ME. The Growing Challenge of 13. Lynch HT, de la Chapelle A. Hereditary colorectal cancer. N Engl J
Young Adults With Colorectal Cancer. Oncology (Williston Park) Med 2003;348:919-932. Available at:
2017;31:381-389. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12621137.
https://www.ncbi.nlm.nih.gov/pubmed/28516436.
14. Galiatsatos P, Foulkes WD. Familial adenomatous polyposis. Am J
6. PubMed Overview. Available at: https://pubmed.ncbi.nlm.nih.gov/about/. Gastroenterol 2006;101:385-398. Available at:
Accessed September 30, 2022. http://www.ncbi.nlm.nih.gov/pubmed/16454848.

7. Ahsan H, Neugut AI, Garbowski GC, et al. Family history of colorectal 15. Hennink SD, van der Meulen-de Jong AE, Wolterbeek R, et al.
adenomatous polyps and increased risk for colorectal cancer. Ann Intern Randomized comparison of surveillance intervals in familial colorectal
Med 1998;128:900-905. Available at: cancer. J Clin Oncol 2015;33:4188-4193. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/9634428. http://www.ncbi.nlm.nih.gov/pubmed/26527788.

8. Bonelli L, Martines H, Conio M, et al. Family history of colorectal cancer 16. Guinney J, Dienstmann R, Wang X, et al. The consensus molecular
as a risk factor for benign and malignant tumours of the large bowel. A subtypes of colorectal cancer. Nat Med 2015;21:1350-1356. Available at:
case-control study. Int J Cancer 1988;41:513-517. Available at: http://www.ncbi.nlm.nih.gov/pubmed/26457759.
http://www.ncbi.nlm.nih.gov/pubmed/3356486.
17. Aaltonen LA, Salovaara R, Kristo P, et al. Incidence of hereditary
nonpolyposis colorectal cancer and the feasibility of molecular screening

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for the disease. N Engl J Med 1998;338:1481-1487. Available at: 25. Palomaki GE, McClain MR, Melillo S, et al. EGAPP supplementary
http://www.ncbi.nlm.nih.gov/pubmed/9593786. evidence review: DNA testing strategies aimed at reducing morbidity and
mortality from Lynch syndrome. Genet Med 2009;11:42-65. Available at:
18. Hampel H, Frankel WL, Martin E, et al. Screening for the Lynch http://www.ncbi.nlm.nih.gov/pubmed/19125127.
syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med
2005;352:1851-1860. Available at: 26. Ladabaum U, Wang G, Terdiman J, et al. Strategies to identify the
http://www.ncbi.nlm.nih.gov/pubmed/15872200. Lynch syndrome among patients with colorectal cancer: a cost-
effectiveness analysis. Ann Intern Med 2011;155:69-79. Available at:
19. Hendriks YM, de Jong AE, Morreau H, et al. Diagnostic approach and http://www.ncbi.nlm.nih.gov/pubmed/21768580.
management of Lynch syndrome (hereditary nonpolyposis colorectal
carcinoma): a guide for clinicians. CA Cancer J Clin 2006;56:213-225. 27. Sepulveda AR, Hamilton SR, Allegra CJ, et al. Molecular Biomarkers
Available at: http://www.ncbi.nlm.nih.gov/pubmed/16870997. for the Evaluation of Colorectal Cancer: Guideline From the American
Society for Clinical Pathology, College of American Pathologists,
20. Ward RL, Hicks S, Hawkins NJ. Population-based molecular screening Association for Molecular Pathology, and American Society of Clinical
for Lynch syndrome: implications for personalized medicine. J Clin Oncol Oncology. J Mol Diagn 2017;19:187-225. Available at:
2013;31:2554-2562. Available at: https://www.ncbi.nlm.nih.gov/pubmed/28185757.
http://www.ncbi.nlm.nih.gov/pubmed/23733757.
28. Giardiello FM, Allen JI, Axilbund JE, et al. Guidelines on genetic
21. Matloff J, Lucas A, Polydorides AD, Itzkowitz SH. Molecular tumor evaluation and management of Lynch syndrome: a consensus statement
testing for Lynch syndrome in patients with colorectal cancer. J Natl by the US Multi-Society Task Force on Colorectal Cancer. Am J
Compr Canc Netw 2013;11:1380-1385. Available at: Gastroenterol 2014;109:1159-1179. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24225971. http://www.ncbi.nlm.nih.gov/pubmed/25070057.
22. Burt RW. Who should have genetic testing for the lynch syndrome? 29. Rubenstein JH, Enns R, Heidelbaugh J, et al. American
Ann Intern Med 2011;155:127-128. Available at: Gastroenterological Association Institute guideline on the diagnosis and
http://www.ncbi.nlm.nih.gov/pubmed/21768586. management of Lynch syndrome. Gastroenterology 2015;149:777-782.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/26226577.
23. Beamer LC, Grant ML, Espenschied CR, et al. Reflex
immunohistochemistry and microsatellite instability testing of colorectal 30. Heald B, Plesec T, Liu X, et al. Implementation of universal
tumors for Lynch syndrome among US cancer programs and follow-up of microsatellite instability and immunohistochemistry screening for
abnormal results. J Clin Oncol 2012;30:1058-1063. Available at: diagnosing lynch syndrome in a large academic medical center. J Clin
http://www.ncbi.nlm.nih.gov/pubmed/22355048. Oncol 2013;31:1336-1340. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/23401454.
24. Recommendations from the EGAPP Working Group: genetic testing
strategies in newly diagnosed individuals with colorectal cancer aimed at 31. Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health: a
reducing morbidity and mortality from Lynch syndrome in relatives. Genet systematic review. Lancet Diabetes Endocrinol 2014;2:76-89. Available at:
Med 2009;11:35-41. Available at: http://www.ncbi.nlm.nih.gov/pubmed/24622671.
http://www.ncbi.nlm.nih.gov/pubmed/19125126.

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32. Chung M, Lee J, Terasawa T, et al. Vitamin D with or without calcium 2008;26:2984-2991. Available at:
supplementation for prevention of cancer and fractures: an updated meta- http://www.ncbi.nlm.nih.gov/pubmed/18565885.
analysis for the U.S. Preventive Services Task Force. Ann Intern Med
2011;155:827-838. Available at: 40. Fedirko V, Riboli E, Tjonneland A, et al. Prediagnostic 25-
http://www.ncbi.nlm.nih.gov/pubmed/22184690. hydroxyvitamin D, VDR and CASR polymorphisms, and survival in
patients with colorectal cancer in western European populations. Cancer
33. Ekmekcioglu C, Haluza D, Kundi M. 25-Hydroxyvitamin D Status and Epidemiol Biomarkers Prev 2012;21:582-593. Available at:
Risk for Colorectal Cancer and Type 2 Diabetes Mellitus: A Systematic http://www.ncbi.nlm.nih.gov/pubmed/22278364.
Review and Meta-Analysis of Epidemiological Studies. Int J Environ Res
Public Health 2017;14:127. Available at: 41. Yuan C, Sato K, Hollis BW, et al. Plasma 25-Hydroxyvitamin D Levels
https://www.ncbi.nlm.nih.gov/pubmed/28134804. and Survival in Patients with Advanced or Metastatic Colorectal Cancer:
Findings from CALGB/SWOG 80405 (Alliance). Clin Cancer Res
34. Gorham ED, Garland CF, Garland FC, et al. Optimal vitamin D status 2019:7497-7505. Available at:
for colorectal cancer prevention: a quantitative meta analysis. Am J Prev https://www.ncbi.nlm.nih.gov/pubmed/31548349.
Med 2007;32:210-216. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/17296473. 42. Maalmi H, Ordonez-Mena JM, Schottker B, Brenner H. Serum 25-
hydroxyvitamin D levels and survival in colorectal and breast cancer
35. Lappe JM, Travers-Gustafson D, Davies KM, et al. Vitamin D and patients: systematic review and meta-analysis of prospective cohort
calcium supplementation reduces cancer risk: results of a randomized studies. Eur J Cancer 2014;50:1510-1521. Available at:
trial. Am J Clin Nutr 2007;85:1586-1591. Available at: http://www.ncbi.nlm.nih.gov/pubmed/24582912.
http://www.ncbi.nlm.nih.gov/pubmed/17556697.
43. Ou B, Zhao J, Guan S, Lu A. Plasma 25-hydroxyvitamin D levels and
36. Ma Y, Zhang P, Wang F, et al. Association between vitamin D and risk survival of colorectal cancer patients: a meta-analysis. Eur J Cancer
of colorectal cancer: a systematic review of prospective studies. J Clin 2015;51:786-788. Available at:
Oncol 2011;29:3775-3782. Available at: http://www.ncbi.nlm.nih.gov/pubmed/25746389.
http://www.ncbi.nlm.nih.gov/pubmed/21876081.
44. Baron JA, Barry EL, Mott LA, et al. A trial of calcium and vitamin D for
37. McCullough ML, Zoltick ES, Weinstein SJ, et al. Circulating Vitamin D the prevention of colorectal adenomas. N Engl J Med 2015;373:1519-
and Colorectal Cancer Risk: An International Pooling Project of 17 1530. Available at: http://www.ncbi.nlm.nih.gov/pubmed/26465985.
Cohorts. JNCI: Journal of the National Cancer Institute 2019;111:158-169.
Available at: http://dx.doi.org/10.1093/jnci/djy087. 45. Barry EL, Peacock JL, Rees JR, et al. Vitamin D Receptor Genotype,
Vitamin D3 Supplementation, and Risk of Colorectal Adenomas: A
38. Zgaga L, Theodoratou E, Farrington SM, et al. Plasma vitamin D Randomized Clinical Trial. JAMA Oncol 2017;3:628-635. Available at:
concentration influences survival outcome after a diagnosis of colorectal https://www.ncbi.nlm.nih.gov/pubmed/27978548.
cancer. J Clin Oncol 2014;32:2430-2439. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/25002714. 46. Urashima M, Ohdaira H, Akutsu T, et al. Effect of Vitamin D
Supplementation on Relapse-Free Survival Among Patients With
39. Ng K, Meyerhardt JA, Wu K, et al. Circulating 25-hydroxyvitamin D Digestive Tract Cancers: The AMATERASU Randomized Clinical Trial.
levels and survival in patients with colorectal cancer. J Clin Oncol

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Jama 2019;321:1361-1369. Available at: 54. Schmid D, Leitzmann MF. Television viewing and time spent
https://www.ncbi.nlm.nih.gov/pubmed/30964526. sedentary in relation to cancer risk: a meta-analysis. J Natl Cancer Inst
2014;106:dju098. Available at:
47. Lewis C, Xun P, He K. Vitamin D supplementation and quality of life http://www.ncbi.nlm.nih.gov/pubmed/24935969.
following diagnosis in stage II colorectal cancer patients: a 24-month
prospective study. Support Care Cancer 2016;24:1655-1661. Available at: 55. Parajuli R, Bjerkaas E, Tverdal A, et al. The increased risk of colon
https://www.ncbi.nlm.nih.gov/pubmed/26408324. cancer due to cigarette smoking may be greater in women than men.
Cancer Epidemiol Biomarkers Prev 2013;22:862-871. Available at:
48. Jeffreys M, Redaniel MT, Martin RM. The effect of pre-diagnostic http://www.ncbi.nlm.nih.gov/pubmed/23632818.
vitamin D supplementation on cancer survival in women: a cohort study
within the UK Clinical Practice Research Datalink. BMC Cancer 56. Magalhaes B, Peleteiro B, Lunet N. Dietary patterns and colorectal
2015;15:670. Available at: cancer: systematic review and meta-analysis. Eur J Cancer Prev
https://www.ncbi.nlm.nih.gov/pubmed/26458897. 2012;21:15-23. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/21946864.
49. Ng K, Nimeiri HS, McCleary NJ, et al. Effect of High-Dose vs
Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival 57. Ma Y, Yang Y, Wang F, et al. Obesity and risk of colorectal cancer: a
Among Patients With Advanced or Metastatic Colorectal Cancer: The systematic review of prospective studies. PLoS One 2013;8:e53916.
SUNSHINE Randomized Clinical Trial. Jama 2019;321:1370-1379. Available at: http://www.ncbi.nlm.nih.gov/pubmed/23349764.
Available at: https://www.ncbi.nlm.nih.gov/pubmed/30964527.
58. Lauby-Secretan B, Scoccianti C, Loomis D, et al. Body fatness and
50. Ross AC, Taylor CL, Yaktine AL, Valle HBD, eds. Dietary Reference cancer--viewpoint of the IARC Working Group. N Engl J Med
Intakes for Calcium and Vitamin D. Washington (DC): National Academies 2016;375:794-798. Available at:
Press (US); 2011. http://www.ncbi.nlm.nih.gov/pubmed/27557308.

51. Lutgens MW, van Oijen MG, van der Heijden GJ, et al. Declining risk 59. Keum N, Greenwood DC, Lee DH, et al. Adult weight gain and
of colorectal cancer in inflammatory bowel disease: an updated meta- adiposity-related cancers: a dose-response meta-analysis of prospective
analysis of population-based cohort studies. Inflamm Bowel Dis observational studies. J Natl Cancer Inst 2015;107:dju428. Available at:
2013;19:789-799. Available at: http://www.ncbi.nlm.nih.gov/pubmed/25618901.
http://www.ncbi.nlm.nih.gov/pubmed/23448792.
60. Esposito K, Chiodini P, Capuano A, et al. Colorectal cancer
52. Johnson CM, Wei C, Ensor JE, et al. Meta-analyses of colorectal association with metabolic syndrome and its components: a systematic
cancer risk factors. Cancer Causes Control 2013;24:1207-1222. Available review with meta-analysis. Endocrine 2013;44:634-647. Available at:
at: http://www.ncbi.nlm.nih.gov/pubmed/23563998. http://www.ncbi.nlm.nih.gov/pubmed/23546613.

53. Beaugerie L, Svrcek M, Seksik P, et al. Risk of colorectal high-grade 61. De Bruijn KM, Arends LR, Hansen BE, et al. Systematic review and
dysplasia and cancer in a prospective observational cohort of patients with meta-analysis of the association between diabetes mellitus and incidence
inflammatory bowel disease. Gastroenterology 2013;145:166-175 e168. and mortality in breast and colorectal cancer. Br J Surg 2013;100:1421-
Available at: http://www.ncbi.nlm.nih.gov/pubmed/23541909. 1429. Available at: http://www.ncbi.nlm.nih.gov/pubmed/24037561.

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Rectal Cancer

62. Cheng J, Chen Y, Wang X, et al. Meta-analysis of prospective cohort studies, an update of the evidence of the WCRF-AICR Continuous Update
studies of cigarette smoking and the incidence of colon and rectal cancers. Project. Ann Oncol 2017;28:1788-1802. Available at:
Eur J Cancer Prev 2014;24:6-15. Available at: https://www.ncbi.nlm.nih.gov/pubmed/28407090.
http://www.ncbi.nlm.nih.gov/pubmed/24722538.
70. Botteri E, Borroni E, Sloan EK, et al. Smoking and Colorectal Cancer
63. Kitahara CM, Berndt SI, de Gonzalez AB, et al. Prospective Risk, Overall and by Molecular Subtypes: A Meta-Analysis. Am J
investigation of body mass index, colorectal adenoma, and colorectal Gastroenterol 2020;115:1940-1949. Available at:
cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. https://www.ncbi.nlm.nih.gov/pubmed/32773458.
J Clin Oncol 2013;31:2450-2459. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/23715565. 71. Aleksandrova K, Pischon T, Jenab M, et al. Combined impact of
healthy lifestyle factors on colorectal cancer: a large European cohort
64. Klatsky AL, Li Y, Nicole Tran H, et al. Alcohol intake, beverage choice, study. BMC Med 2014;12:168. Available at:
and cancer: a cohort study in a large kaiser permanente population. Perm http://www.ncbi.nlm.nih.gov/pubmed/25319089.
J 2015;19:28-34. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/25785639. 72. Song M, Giovannucci E. Preventable incidence and mortality of
carcinoma associated with lifestyle factors among white adults in the
65. Kyu HH, Bachman VF, Alexander LT, et al. Physical activity and risk of United States. JAMA Oncol 2016;2:1154-1161. Available at:
breast cancer, colon cancer, diabetes, ischemic heart disease, and http://www.ncbi.nlm.nih.gov/pubmed/27196525.
ischemic stroke events: systematic review and dose-response meta-
analysis for the Global Burden of Disease Study 2013. BMJ 73. Kohler LN, Garcia DO, Harris RB, et al. Adherence to diet and physical
2016;354:i3857. Available at: activity cancer prevention guidelines and cancer outcomes: a systematic
http://www.ncbi.nlm.nih.gov/pubmed/27510511. review. Cancer Epidemiol Biomarkers Prev 2016;25:1018-1028. Available
at: http://www.ncbi.nlm.nih.gov/pubmed/27340121.
66. Luo W, Cao Y, Liao C, Gao F. Diabetes mellitus and the incidence and
mortality of colorectal cancer: a meta-analysis of 24 cohort studies. 74. Murphy N, Norat T, Ferrari P, et al. Consumption of dairy products and
Colorectal Dis 2012;14:1307-1312. Available at: colorectal cancer in the European Prospective Investigation into Cancer
http://www.ncbi.nlm.nih.gov/pubmed/23046351. and Nutrition (EPIC). PLoS One 2013;8:e72715. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24023767.
67. Moore SC, Lee IM, Weiderpass E, et al. Association of leisure-time
physical activity with risk of 26 types of cancer in 1.44 million adults. JAMA 75. Keum N, Aune D, Greenwood DC, et al. Calcium intake and colorectal
Intern Med 2016;176:816-825. Available at: cancer risk: dose-response meta-analysis of prospective observational
http://www.ncbi.nlm.nih.gov/pubmed/27183032. studies. Int J Cancer 2014;135:1940-1948. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24623471.
68. Shen D, Mao W, Liu T, et al. Sedentary behavior and incident cancer:
a meta-analysis of prospective studies. PLoS One 2014;9:e105709. 76. Ralston RA, Truby H, Palermo CE, Walker KZ. Colorectal cancer and
Available at: http://www.ncbi.nlm.nih.gov/pubmed/25153314. nonfermented milk, solid cheese, and fermented milk consumption: a
systematic review and meta-analysis of prospective studies. Crit Rev Food
69. Vieira AR, Abar L, Chan DSM, et al. Foods and beverages and Sci Nutr 2014;54:1167-1179. Available at:
colorectal cancer risk: a systematic review and meta-analysis of cohort http://www.ncbi.nlm.nih.gov/pubmed/24499149.

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77. Zhu B, Sun Y, Qi L, et al. Dietary legume consumption reduces risk of 85. Cao Y, Nishihara R, Wu K, et al. Population-wide impact of long-term
colorectal cancer: evidence from a meta-analysis of cohort studies. Sci use of aspirin and the risk for cancer. JAMA Oncol 2016;2:762-769.
Rep 2015;5:8797. Available at: Available at: http://www.ncbi.nlm.nih.gov/pubmed/26940135.
http://www.ncbi.nlm.nih.gov/pubmed/25739376.
86. Guirguis-Blake JM, Evans CV, Perdue LA, et al. Aspirin Use to
78. Orlich MJ, Singh PN, Sabate J, et al. Vegetarian dietary patterns and Prevent Cardiovascular Disease and Colorectal Cancer: Updated
the risk of colorectal cancers. JAMA Intern Med 2015;175:767-776. Evidence Report and Systematic Review for the US Preventive Services
Available at: http://www.ncbi.nlm.nih.gov/pubmed/25751512. Task Force. JAMA 2022;327:1585-1597. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/35471507.
79. Yu XF, Zou J, Dong J. Fish consumption and risk of gastrointestinal
cancers: a meta-analysis of cohort studies. World J Gastroenterol 87. Force USPST, Davidson KW, Barry MJ, et al. Aspirin Use to Prevent
2014;20:15398-15412. Available at: Cardiovascular Disease: US Preventive Services Task Force
http://www.ncbi.nlm.nih.gov/pubmed/25386090. Recommendation Statement. JAMA 2022;327:1577-1584. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/35471505.
80. Rothwell PM, Wilson M, Elwin CE, et al. Long-term effect of aspirin on
colorectal cancer incidence and mortality: 20-year follow-up of five 88. Walter V, Jansen L, Hoffmeister M, Brenner H. Smoking and survival
randomised trials. Lancet 2010;376:1741-1750. Available at: of colorectal cancer patients: systematic review and meta-analysis. Ann
http://www.ncbi.nlm.nih.gov/pubmed/20970847. Oncol 2014;25:1517-1525. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24692581.
81. Friis S, Riis AH, Erichsen R, et al. Low-dose aspirin or nonsteroidal
anti-inflammatory drug use and colorectal cancer risk: a population-based, 89. Sinicrope FA, Foster NR, Yoon HH, et al. Association of obesity with
case-control study. Ann Intern Med 2015;163:347-355. Available at: DNA mismatch repair status and clinical outcome in patients with stage II
http://www.ncbi.nlm.nih.gov/pubmed/26302241. or III colon carcinoma participating in NCCTG and NSABP adjuvant
chemotherapy trials. J Clin Oncol 2012;30:406-412. Available at:
82. Friis S, Poulsen AH, Sorensen HT, et al. Aspirin and other non- http://www.ncbi.nlm.nih.gov/pubmed/22203756.
steroidal anti-inflammatory drugs and risk of colorectal cancer: a Danish
cohort study. Cancer Causes Control 2009;20:731-740. Available at: 90. Phipps AI, Shi Q, Newcomb PA, et al. Associations between cigarette
http://www.ncbi.nlm.nih.gov/pubmed/19122977. smoking status and colon cancer prognosis among participants in North
Central Cancer Treatment Group phase III trial N0147. J Clin Oncol
83. Flossmann E, Rothwell PM, British Doctors Aspirin T, the UKTIAAT. 2013;31:2016-2023. Available at:
Effect of aspirin on long-term risk of colorectal cancer: consistent evidence http://www.ncbi.nlm.nih.gov/pubmed/23547084.
from randomised and observational studies. Lancet 2007;369:1603-1613.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/17499602. 91. McCullough ML, Gapstur SM, Shah R, et al. Association between red
and processed meat intake and mortality among colorectal cancer
84. Chan AT, Giovannucci EL, Meyerhardt JA, et al. Long-term use of survivors. J Clin Oncol 2013;31:2773-2782. Available at:
aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal http://www.ncbi.nlm.nih.gov/pubmed/23816965.
cancer. JAMA 2005;294:914-923. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/16118381. 92. Yang B, Jacobs EJ, Gapstur SM, et al. Active smoking and mortality
among colorectal cancer survivors: the Cancer Prevention Study II

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nutrition cohort. J Clin Oncol 2015;33:885-893. Available at: 100. Rokkas T, Portincasa P. Colon neoplasia in patients with type 2
http://www.ncbi.nlm.nih.gov/pubmed/25646196. diabetes on metformin: A meta-analysis. Eur J Intern Med 2016;33:60-66.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/27318643.
93. Song M, Zhang X, Meyerhardt JA, et al. Marine omega-3
polyunsaturated fatty acid intake and survival after colorectal cancer 101. Nie Z, Zhu H, Gu M. Reduced colorectal cancer incidence in type 2
diagnosis. Gut 2016;66:1790-1796. Available at: diabetic patients treated with metformin: a meta-analysis. Pharm Biol
http://www.ncbi.nlm.nih.gov/pubmed/27436272. 2016;54:2636-2642. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/27159666.
94. Morris EJ, Penegar S, Whitehouse LE, et al. A retrospective
observational study of the relationship between family history and survival 102. Karlstad O, Starup-Linde J, Vestergaard P, et al. Use of insulin and
from colorectal cancer. Br J Cancer 2013;108:1502-1507. Available at: insulin analogs and risk of cancer - systematic review and meta-analysis
http://www.ncbi.nlm.nih.gov/pubmed/23511565. of observational studies. Curr Drug Saf 2013;8:333-348. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24215311.
95. Yang B, McCullough ML, Gapstur SM, et al. Calcium, vitamin D, dairy
products, and mortality among colorectal cancer survivors: the Cancer 103. He XK, Su TT, Si JM, Sun LM. Metformin is associated with slightly
Prevention Study-II nutrition cohort. J Clin Oncol 2014;32:2335-2343. reduced risk of colorectal cancer and moderate survival benefits in
Available at: http://www.ncbi.nlm.nih.gov/pubmed/24958826. diabetes mellitus: A meta-analysis. Medicine (Baltimore) 2016;95:e2749.
Available at: https://www.ncbi.nlm.nih.gov/pubmed/26886616.
96. Dik VK, Murphy N, Siersema PD, et al. Prediagnostic intake of dairy
products and dietary calcium and colorectal cancer survival-results from 104. Guraya SY. Association of type 2 diabetes mellitus and the risk of
the EPIC Cohort Study. Cancer Epidemiol Biomarkers Prev 2014;23:1813- colorectal cancer: A meta-analysis and systematic review. World J
1823. Available at: http://www.ncbi.nlm.nih.gov/pubmed/24917183. Gastroenterol 2015;21:6026-6031. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/26019469.
97. Zhang ZJ, Li S. The prognostic value of metformin for cancer patients
with concurrent diabetes: a systematic review and meta-analysis. Diabetes 105. Cardel M, Jensen SM, Pottegard A, et al. Long-term use of metformin
Obes Metab 2014;16:707-710. Available at: and colorectal cancer risk in type II diabetics: a population-based case-
http://www.ncbi.nlm.nih.gov/pubmed/24460896. control study. Cancer Med 2014;3:1458-1466. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/25091592.
98. Singh S, Singh H, Singh PP, et al. Antidiabetic medications and the
risk of colorectal cancer in patients with diabetes mellitus: a systematic 106. Bu WJ, Song L, Zhao DY, et al. Insulin therapy and the risk of
review and meta-analysis. Cancer Epidemiol Biomarkers Prev colorectal cancer in patients with type 2 diabetes: a meta-analysis of
2013;22:2258-2268. Available at: observational studies. Br J Clin Pharmacol 2014;78:301-309. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24042261. http://www.ncbi.nlm.nih.gov/pubmed/25099257.

99. Sehdev A, Shih YC, Vekhter B, et al. Metformin for primary colorectal 107. Higurashi T, Hosono K, Takahashi H, et al. Metformin for
cancer prevention in patients with diabetes: a case-control study in a US chemoprevention of metachronous colorectal adenoma or polyps in post-
population. Cancer 2015;121:1071-1078. Available at: polypectomy patients without diabetes: a multicentre double-blind,
http://www.ncbi.nlm.nih.gov/pubmed/25424411. placebo-controlled, randomised phase 3 trial. Lancet Oncol 2016;17:475-
483. Available at: http://www.ncbi.nlm.nih.gov/pubmed/26947328.

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NCCN Guidelines Version 4.2024

Rectal Cancer

108. Zhu B, Wu X, Wu B, et al. The relationship between diabetes and 2016;7:79787-79796. Available at:
colorectal cancer prognosis: A meta-analysis based on the cohort studies. https://www.ncbi.nlm.nih.gov/pubmed/27806332.
PLoS One 2017;12:e0176068. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/28423026. 116. Franko J, Shi Q, Goldman CD, et al. Treatment of colorectal
peritoneal carcinomatosis with systemic chemotherapy: a pooled analysis
109. Mills KT, Bellows CF, Hoffman AE, et al. Diabetes mellitus and of north central cancer treatment group phase III trials N9741 and N9841.
colorectal cancer prognosis: a meta-analysis. Dis Colon Rectum J Clin Oncol 2012;30:263-267. Available at:
2013;56:1304-1319. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22162570.
http://www.ncbi.nlm.nih.gov/pubmed/24105007.
117. Compton CC, Fielding LP, Burgart LJ, et al. Prognostic factors in
110. Meng F, Song L, Wang W. Metformin improves overall survival of colorectal cancer. College of American Pathologists Consensus Statement
colorectal cancer patients with diabetes: A meta-analysis. J Diabetes Res 1999. Arch Pathol Lab Med 2000;124:979-994. Available at:
2017;2017:5063239. Available at: http://www.ncbi.nlm.nih.gov/pubmed/10888773.
https://www.ncbi.nlm.nih.gov/pubmed/28271076.
118. Compton CC, Greene FL. The staging of colorectal cancer: 2004 and
111. Mei ZB, Zhang ZJ, Liu CY, et al. Survival benefits of metformin for beyond. CA Cancer J Clin 2004;54:295-308. Available at:
colorectal cancer patients with diabetes: a systematic review and meta- http://www.ncbi.nlm.nih.gov/pubmed/15537574.
analysis. PLoS One 2014;9:e91818. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24647047. 119. Nagtegaal ID, Marijnen CA, Kranenbarg EK, et al. Circumferential
margin involvement is still an important predictor of local recurrence in
112. Zanders MM, van Herk-Sukel MP, Vissers PA, et al. Are metformin, rectal carcinoma: not one millimeter but two millimeters is the limit. Am J
statin and aspirin use still associated with overall mortality among Surg Pathol 2002;26:350-357. Available at:
colorectal cancer patients with diabetes if adjusted for one another? Br J http://www.ncbi.nlm.nih.gov/pubmed/11859207.
Cancer 2015;113:403-410. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/26180924. 120. Nagtegaal ID, Quirke P. What is the role for the circumferential
margin in the modern treatment of rectal cancer? J Clin Oncol
113. Kowall B, Stang A, Rathmann W, Kostev K. No reduced risk of 2008;26:303-312. Available at:
overall, colorectal, lung, breast, and prostate cancer with metformin http://www.ncbi.nlm.nih.gov/pubmed/18182672.
therapy in diabetic patients: database analyses from Germany and the UK.
Pharmacoepidemiol Drug Saf 2015;24:865-874. Available at: 121. Wibe A, Rendedal PR, Svensson E, et al. Prognostic significance of
http://www.ncbi.nlm.nih.gov/pubmed/26132313. the circumferential resection margin following total mesorectal excision for
rectal cancer. Br J Surg 2002;89:327-334. Available at:
114. Amin MB, Greene FL, Edge S, et al., eds. AJCC Cancer Staging http://www.ncbi.nlm.nih.gov/pubmed/11872058.
Manual (ed 8th Edition). New York: Springer; 2017.
122. Gavioli M, Luppi G, Losi L, et al. Incidence and clinical impact of
115. Huang B, Mo S, Zhu L, et al. The survival and clinicopathological sterilized disease and minimal residual disease after preoperative
differences between patients with stage IIIA and stage II rectal cancer: An radiochemotherapy for rectal cancer. Dis Colon Rectum 2005;48:1851-
analysis of 12,036 patients in the SEER database. Oncotarget 1857. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16132481.

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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Rectal Cancer

123. Rodel C, Martus P, Papadoupolos T, et al. Prognostic significance of 131. Ueno H, Mochizuki H. Clinical significance of extrabowel skipped
tumor regression after preoperative chemoradiotherapy for rectal cancer. J cancer infiltration in rectal cancer. Surg Today 1997;27:617-622. Available
Clin Oncol 2005;23:8688-8696. Available at: at: http://www.ncbi.nlm.nih.gov/pubmed/9306563.
http://www.ncbi.nlm.nih.gov/pubmed/16246976.
132. Ueno H, Mochizuki H, Hashiguchi Y, et al. Extramural cancer
124. Nissan A, Stojadinovic A, Shia J, et al. Predictors of recurrence in deposits without nodal structure in colorectal cancer: optimal
patients with T2 and early T3, N0 adenocarcinoma of the rectum treated categorization for prognostic staging. Am J Clin Pathol 2007;127:287-294.
by surgery alone. J Clin Oncol 2006;24:4078-4084. Available at: Available at: http://www.ncbi.nlm.nih.gov/pubmed/17210518.
http://www.ncbi.nlm.nih.gov/pubmed/16943525.
133. Compton CC. Key issues in reporting common cancer specimens:
125. Fujita S, Shimoda T, Yoshimura K, et al. Prospective evaluation of problems in pathologic staging of colon cancer. Arch Pathol Lab Med
prognostic factors in patients with colorectal cancer undergoing curative 2006;130:318-324. Available at:
resection. J Surg Oncol 2003;84:127-131. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16519558.
http://www.ncbi.nlm.nih.gov/pubmed/14598355.
134. Lai LL, Fuller CD, Kachnic LA, Thomas CR, Jr. Can pelvic
126. Liebig C, Ayala G, Wilks J, et al. Perineural invasion is an radiotherapy be omitted in select patients with rectal cancer? Semin Oncol
independent predictor of outcome in colorectal cancer. J Clin Oncol 2006;33:S70-74. Available at:
2009;27:5131-5137. Available at: http://www.ncbi.nlm.nih.gov/pubmed/17178292.
http://www.ncbi.nlm.nih.gov/pubmed/19738119.
135. Glynne-Jones R, Mawdsley S, Novell JR. The clinical significance of
127. Quah HM, Chou JF, Gonen M, et al. Identification of patients with the circumferential resection margin following preoperative pelvic chemo-
high-risk stage II colon cancer for adjuvant therapy. Dis Colon Rectum radiotherapy in rectal cancer: why we need a common language.
2008;51:503-507. Available at: Colorectal Dis 2006;8:800-807. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/18322753. http://www.ncbi.nlm.nih.gov/pubmed/17032329.

128. Lo DS, Pollett A, Siu LL, et al. Prognostic significance of mesenteric 136. Diagnostic accuracy of preoperative magnetic resonance imaging in
tumor nodules in patients with stage III colorectal cancer. Cancer predicting curative resection of rectal cancer: prospective observational
2008;112:50-54. Available at: study. Bmj 2006;333:779. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/18008365. https://pubmed.ncbi.nlm.nih.gov/16984925/.

129. Nagtegaal ID, Quirke P. Colorectal tumour deposits in the 137. Beets-Tan RGH, Lambregts DMJ, Maas M, et al. Magnetic
mesorectum and pericolon; a critical review. Histopathology 2007;51:141- resonance imaging for clinical management of rectal cancer: Updated
149. Available at: http://www.ncbi.nlm.nih.gov/pubmed/17532768. recommendations from the 2016 European Society of Gastrointestinal and
Abdominal Radiology (ESGAR) consensus meeting. Eur Radiol
130. Puppa G, Maisonneuve P, Sonzogni A, et al. Pathological 2018;28:1465-1475. Available at:
assessment of pericolonic tumor deposits in advanced colonic carcinoma: https://www.ncbi.nlm.nih.gov/pubmed/29043428.
relevance to prognosis and tumor staging. Mod Pathol 2007;20:843-855.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/17491597. 138. Adam IJ, Mohamdee MO, Martin IG, et al. Role of circumferential
margin involvement in the local recurrence of rectal cancer. Lancet

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1994;344:707-711. Available at: 2001;19:157-163. Available at:

http://www.ncbi.nlm.nih.gov/pubmed/7915774. http://www.ncbi.nlm.nih.gov/pubmed/11134208.

139. Mawdsley S, Glynne-Jones R, Grainger J, et al. Can histopathologic 146. Kidner TB, Ozao-Choy JJ, Yoon J, Bilchik AJ. Should quality
assessment of circumferential margin after preoperative pelvic measures for lymph node dissection in colon cancer be extrapolated to
chemoradiotherapy for T3-T4 rectal cancer predict for 3-year disease-free rectal cancer? Am J Surg 2012;204:843-847; discussion 847-848.
survival? Int J Radiat Oncol Biol Phys 2005;63:745-752. Available at: Available at: http://www.ncbi.nlm.nih.gov/pubmed/22981183.
http://www.ncbi.nlm.nih.gov/pubmed/16199310.
147. Baxter NN, Morris AM, Rothenberger DA, Tepper JE. Impact of
140. Hwang MR, Park JW, Park S, et al. Prognostic impact of preoperative radiation for rectal cancer on subsequent lymph node
circumferential resection margin in rectal cancer treated with preoperative evaluation: a population-based analysis. Int J Radiat Oncol Biol Phys
chemoradiotherapy. Ann Surg Oncol 2014;21:1345-1351. Available at: 2005;61:426-431. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24468928. http://www.ncbi.nlm.nih.gov/pubmed/15667963.

141. Tang L, Berlin J, Branton P, et al. Protocol for the examination of 148. Han J, Noh GT, Yeo SA, et al. The number of retrieved lymph nodes
specimens from patients with primary carcinoma of the colon and rectum. needed for accurate staging differs based on the presence of preoperative
College of American Pathologists 2016. Available at: chemoradiation for rectal cancer. Medicine (Baltimore) 2016;95:e4891.
http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution%20F Available at: https://www.ncbi.nlm.nih.gov/pubmed/27661032.
olders/WebContent/pdf/cp-colon-16protocol-3400.pdf.
149. Wichmann MW, Muller C, Meyer G, et al. Effect of preoperative
142. Sarli L, Bader G, Iusco D, et al. Number of lymph nodes examined radiochemotherapy on lymph node retrieval after resection of rectal
and prognosis of TNM stage II colorectal cancer. Eur J Cancer cancer. Arch Surg 2002;137:206-210. Available at:
2005;41:272-279. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11822961.
http://www.ncbi.nlm.nih.gov/pubmed/15661553.
150. de Campos-Lobato LF, Stocchi L, de Sousa JB, et al. Less than 12
143. Wong SL, Ji H, Hollenbeck BK, et al. Hospital lymph node nodes in the surgical specimen after total mesorectal excision following
examination rates and survival after resection for colon cancer. JAMA neoadjuvant chemoradiation: it means more than you think! Ann Surg
2007;298:2149-2154. Available at: Oncol 2013;20:3398-3406. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/18000198. http://www.ncbi.nlm.nih.gov/pubmed/23812804.

144. Pocard M, Panis Y, Malassagne B, et al. Assessing the effectiveness 151. Kim HJ, Jo JS, Lee SY, et al. Low lymph node retrieval after
of mesorectal excision in rectal cancer: prognostic value of the number of preoperative chemoradiation for rectal cancer is associated with improved
lymph nodes found in resected specimens. Dis Colon Rectum prognosis in patients with a good tumor response. Ann Surg Oncol
1998;41:839-845. Available at: 2015;22:2075-2081. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/9678368. http://www.ncbi.nlm.nih.gov/pubmed/25395150.

145. Tepper JE, O'Connell MJ, Niedzwiecki D, et al. Impact of number of 152. Abdulla FA, Wagh M, Muralee M, et al. Prognostic Implications of
nodes retrieved on outcome in patients with rectal cancer. J Clin Oncol Nodal Yield in Rectal Cancer After Neoadjuvant Therapy: Is Nodal Yield

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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Still Relevant Post Neoadjuvant Therapy? Indian Journal of Surgery 2021. systematic review and meta-analysis. Eur J Surg Oncol 2014;40:263-269.
Available at: https://doi.org/10.1007/s12262-021-03154-w. Available at: http://www.ncbi.nlm.nih.gov/pubmed/24368050.

153. Turner RR, Nora DT, Trocha SD, Bilchik AJ. Colorectal carcinoma 160. Mescoli C, Albertoni L, Pucciarelli S, et al. Isolated tumor cells in
nodal staging. Frequency and nature of cytokeratin-positive cells in regional lymph nodes as relapse predictors in stage I and II colorectal
sentinel and nonsentinel lymph nodes. Arch Pathol Lab Med cancer. J Clin Oncol 2012;30:965-971. Available at:
2003;127:673-679. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22355061.
http://www.ncbi.nlm.nih.gov/pubmed/12741889.
161. Rahbari NN, Bork U, Motschall E, et al. Molecular detection of tumor
154. Wood TF, Nora DT, Morton DL, et al. One hundred consecutive cells in regional lymph nodes is associated with disease recurrence and
cases of sentinel lymph node mapping in early colorectal carcinoma: poor survival in node-negative colorectal cancer: a systematic review and
detection of missed micrometastases. J Gastrointest Surg 2002;6:322- meta-analysis. J Clin Oncol 2012;30:60-70. Available at:
329; discussion 229-330. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22124103.
http://www.ncbi.nlm.nih.gov/pubmed/12022982.
162. Kakar S, Shi C, Berho ME, et al. Protocol for the Examination of
155. Yasuda K, Adachi Y, Shiraishi N, et al. Pattern of lymph node Specimens From Patients With Primary Carcinoma of the Colon and
micrometastasis and prognosis of patients with colorectal cancer. Ann Rectum. College of American Pathologists 2017. Available at:
Surg Oncol 2001;8:300-304. Available at: https://documents.cap.org/protocols/cp-gilower-colonrectum-17protocol-
http://www.ncbi.nlm.nih.gov/pubmed/11352302. 4010.pdf.

156. Braat AE, Oosterhuis JW, Moll FC, et al. Sentinel node detection 163. Ryan R, Gibbons D, Hyland JM, et al. Pathological response
after preoperative short-course radiotherapy in rectal carcinoma is not following long-course neoadjuvant chemoradiotherapy for locally
reliable. Br J Surg 2005;92:1533-1538. Available at: advanced rectal cancer. Histopathology 2005;47:141-146. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/16231281. http://www.ncbi.nlm.nih.gov/pubmed/16045774.

157. Wiese D, Sirop S, Yestrepsky B, et al. Ultrastaging of sentinel lymph 164. Al-Sukhni E, Attwood K, Gabriel EM, et al. Lymphovascular and
nodes (SLNs) vs. non-SLNs in colorectal cancer--do we need both? Am J perineural invasion are associated with poor prognostic features and
Surg 2010;199:354-358; discussion 358. Available at: outcomes in colorectal cancer: A retrospective cohort study. Int J Surg
http://www.ncbi.nlm.nih.gov/pubmed/20226909. 2016;37:42-49. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/27600906.
158. Noura S, Yamamoto H, Miyake Y, et al. Immunohistochemical
assessment of localization and frequency of micrometastases in lymph 165. Knijn N, Mogk SC, Teerenstra S, et al. Perineural invasion is a strong
nodes of colorectal cancer. Clin Cancer Res 2002;8:759-767. Available at: prognostic factor in colorectal cancer: a systematic review. Am J Surg
http://www.ncbi.nlm.nih.gov/pubmed/11895906. Pathol 2016;40:103-112. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/26426380.
159. Sloothaak DA, Sahami S, van der Zaag-Loonen HJ, et al. The
prognostic value of micrometastases and isolated tumour cells in 166. Mayo E, Llanos AA, Yi X, et al. Prognostic value of tumour deposit
histologically negative lymph nodes of patients with colorectal cancer: a and perineural invasion status in colorectal cancer patients: a SEER-

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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Rectal Cancer

based population study. Histopathology 2016;69:230-238. Available at: 174. Pai RK, Cheng YW, Jakubowski MA, et al. Colorectal carcinomas
http://www.ncbi.nlm.nih.gov/pubmed/26802566. with submucosal invasion (pT1): analysis of histopathological and
molecular factors predicting lymph node metastasis. Mod Pathol
167. Yagi R, Shimada Y, Kameyama H, et al. Clinical significance of 2017;30:113-122. Available at:
extramural tumor deposits in the lateral pelvic lymph node area in low https://pubmed.ncbi.nlm.nih.gov/27713420/.
rectal cancer: a retrospective study at two institutions. Ann Surg Oncol
2016;23:552-558. Available at: 175. Backes Y, Elias SG, Groen JN, et al. Histologic Factors Associated
https://www.ncbi.nlm.nih.gov/pubmed/27393567. With Need for Surgery in Patients With Pedunculated T1 Colorectal
Carcinomas. Gastroenterology 2018;154:1647-1659. Available at:
168. Gopal P, Lu P, Ayers GD, et al. Tumor deposits in rectal https://pubmed.ncbi.nlm.nih.gov/29366842/.
adenocarcinoma after neoadjuvant chemoradiation are associated with
poor prognosis. Mod Pathol 2014;27:1281-1287. Available at: 176. Brown IS, Bettington ML, Bettington A, et al. Adverse histological
http://www.ncbi.nlm.nih.gov/pubmed/24434897. features in malignant colorectal polyps: a contemporary series of 239
cases. J Clin Pathol 2016;69:292-299. Available at:
169. Zhang LN, Xiao WW, Xi SY, et al. Tumor deposits: markers of poor https://pubmed.ncbi.nlm.nih.gov/26424814/.
prognosis in patients with locally advanced rectal cancer following
neoadjuvant chemoradiotherapy. Oncotarget 2015;7:6335-6344. Available 177. Lee VWK, Chan KF. Tumor budding and poorly-differentiated cluster
at: http://www.ncbi.nlm.nih.gov/pubmed/26695441. in prognostication in Stage II colon cancer. Pathol Res Pract
2018;214:402-407. Available at:
170. Lord AC, Graham Martínez C, D'Souza N, et al. The significance of https://pubmed.ncbi.nlm.nih.gov/29487008/.
tumour deposits in rectal cancer after neoadjuvant therapy: a systematic
review and meta-analysis. Eur J Cancer 2019;122:1-8. Available at: 178. Romiti A, Roberto M, Marchetti P, et al. Study of histopathologic
https://pubmed.ncbi.nlm.nih.gov/31593786/. parameters to define the prognosis of stage II colon cancer. Int J
Colorectal Dis 2019;34:905-913. Available at:
171. Lugli A, Kirsch R, Ajioka Y, et al. Recommendations for reporting https://pubmed.ncbi.nlm.nih.gov/30915540/.
tumor budding in colorectal cancer based on the International Tumor
Budding Consensus Conference (ITBCC) 2016. Mod Pathol 179. Hamilton SR, Bosman FT, Boffetta P, et al. Carcinoma of the colon
2017;30:1299-1311. Available at: and rectum. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, eds.
https://pubmed.ncbi.nlm.nih.gov/28548122/. WHO Classification of Tumours of the Digestive System. Lyon: IARC;
2010.
172. Bosch SL, Teerenstra S, de Wilt JH, et al. Predicting lymph node
metastasis in pT1 colorectal cancer: a systematic review of risk factors 180. Cooper HS, Deppisch LM, Gourley WK, et al. Endoscopically
providing rationale for therapy decisions. Endoscopy 2013;45:827-834. removed malignant colorectal polyps: clinicopathologic correlations.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/23884793. Gastroenterology 1995;108:1657-1665. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/7768369.
173. Koelzer VH, Zlobec I, Lugli A. Tumor budding in colorectal cancer--
ready for diagnostic practice? Hum Pathol 2016;47:4-19. Available at: 181. Yoshii S, Nojima M, Nosho K, et al. Factors associated with risk for
https://pubmed.ncbi.nlm.nih.gov/26476568/. colorectal cancer recurrence after endoscopic resection of T1 tumors. Clin

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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Rectal Cancer

Gastroenterol Hepatol 2014;12:292-302 e293. Available at: 189. Baxter NN, Garcia-Aguilar J. Organ preservation for rectal cancer. J
http://www.ncbi.nlm.nih.gov/pubmed/23962552. Clin Oncol 2007;25:1014-1020. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/17350952.
182. Seitz U, Bohnacker S, Seewald S, et al. Is endoscopic polypectomy
an adequate therapy for malignant colorectal adenomas? Presentation of 190. Rajput A, Bullard Dunn K. Surgical management of rectal cancer.
114 patients and review of the literature. Dis Colon Rectum 2004;47:1789- Semin Oncol 2007;34:241-249. Available at:
1796. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15622570. http://www.ncbi.nlm.nih.gov/pubmed/17560986.

183. Ueno H, Mochizuki H, Hashiguchi Y, et al. Risk factors for an adverse 191. Weiser MR, Landmann RG, Wong WD, et al. Surgical salvage of
outcome in early invasive colorectal carcinoma. Gastroenterology recurrent rectal cancer after transanal excision. Dis Colon Rectum
2004;127:385-394. Available at: 2005;48:1169-1175. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/15300569. http://www.ncbi.nlm.nih.gov/pubmed/15793645.

184. Volk EE, Goldblum JR, Petras RE, et al. Management and outcome 192. Wiig JN, Larsen SG, Giercksky KE. Operative treatment of locally
of patients with invasive carcinoma arising in colorectal polyps. recurrent rectal cancer. Recent Results Cancer Res 2005;165:136-147.
Gastroenterology 1995;109:1801-1807. Available at: Available at: http://www.ncbi.nlm.nih.gov/pubmed/15865028.
http://www.ncbi.nlm.nih.gov/pubmed/7498644.
193. Morino M, Risio M, Bach S, et al. Early rectal cancer: the European
185. Choi DH, Sohn DK, Chang HJ, et al. Indications for subsequent Association for Endoscopic Surgery (EAES) clinical consensus
surgery after endoscopic resection of submucosally invasive colorectal conference. Surg Endosc 2015;29:755-773. Available at:
carcinomas: a prospective cohort study. Dis Colon Rectum 2009;52:438- https://www.ncbi.nlm.nih.gov/pubmed/25609317.
445. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19333043.
194. Bartram C, Brown G. Endorectal ultrasound and magnetic resonance
186. Choi JY, Jung SA, Shim KN, et al. Meta-analysis of predictive imaging in rectal cancer staging. Gastroenterol Clin North Am
clinicopathologic factors for lymph node metastasis in patients with early 2002;31:827-839. Available at:
colorectal carcinoma. J Korean Med Sci 2015;30:398-406. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12481733.
http://www.ncbi.nlm.nih.gov/pubmed/25829807.
195. Zhang G, Cai YZ, Xu GH. Diagnostic accuracy of MRI for
187. Park KJ, Choi HJ, Roh MS, et al. Intensity of tumor budding and its assessment of T category and circumferential resection margin
prognostic implications in invasive colon carcinoma. Dis Colon Rectum involvement in patients with rectal cancer: A meta-analysis. Dis Colon
2005;48:1597-1602. Available at: Rectum 2016;59:789-799. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/15937624. https://www.ncbi.nlm.nih.gov/pubmed/27384098.

188. Rogers AC, Winter DC, Heeney A, et al. Systematic review and 196. Balyasnikova S, Brown G. Optimal imaging strategies for rectal
meta-analysis of the impact of tumour budding in colorectal cancer. Br J cancer staging and ongoing management. Curr Treat Options Oncol
Cancer 2016;115:831-840. Available at: 2016;17:32. Available at: https://www.ncbi.nlm.nih.gov/pubmed/27255100.
http://www.ncbi.nlm.nih.gov/pubmed/27599041.
197. Battersby NJ, How P, Moran B, et al. Prospective validation of a low
rectal cancer magnetic resonance imaging staging system and

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Rectal Cancer

development of a local recurrence risk stratification model: The 205. Wolberink SV, Beets-Tan RG, de Haas-Kock DF, et al. Conventional
MERCURY II Study. Ann Surg 2016;263:751-760. Available at: CT for the prediction of an involved circumferential resection margin in
https://www.ncbi.nlm.nih.gov/pubmed/25822672. primary rectal cancer. Dig Dis 2007;25:80-85. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/17384512.
198. Beets-Tan RG, Beets GL. Rectal cancer: review with emphasis on
MR imaging. Radiology 2004;232:335-346. Available at: 206. Ashraf S, Hompes R, Slater A, et al. A critical appraisal of endorectal
http://www.ncbi.nlm.nih.gov/pubmed/15286305. ultrasound and transanal endoscopic microsurgery and decision-making in
early rectal cancer. Colorectal Dis 2012;14:821-826. Available at:
199. Klessen C, Rogalla P, Taupitz M. Local staging of rectal cancer: the https://www.ncbi.nlm.nih.gov/pubmed/21920011.
current role of MRI. Eur Radiol 2007;17:379-389. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/17008990. 207. Choi DJ, Kwak JM, Kim J, et al. Preoperative chest computerized
tomography in patients with locally advanced mid or lower rectal cancer:
200. Lahaye MJ, Engelen SM, Nelemans PJ, et al. Imaging for predicting its role in staging and impact on treatment strategy. J Surg Oncol
the risk factors--the circumferential resection margin and nodal disease--of 2010;102:588-592. Available at:
local recurrence in rectal cancer: a meta-analysis. Semin Ultrasound CT https://www.ncbi.nlm.nih.gov/pubmed/20607759.
MR 2005;26:259-268. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/16152740. 208. Grossmann I, Avenarius JK, Mastboom WJ, Klaase JM. Preoperative
staging with chest CT in patients with colorectal carcinoma: not as a
201. Xie H, Zhou X, Zhuo Z, et al. Effectiveness of MRI for the routine procedure. Ann Surg Oncol 2010;17:2045-2050. Available at:
assessment of mesorectal fascia involvement in patients with rectal https://www.ncbi.nlm.nih.gov/pubmed/20151212.
cancer: a systematic review and meta-analysis. Dig Surg 2014;31:123-
134. Available at: http://www.ncbi.nlm.nih.gov/pubmed/24942675. 209. Qiu M, Hu J, Yang D, et al. Pattern of distant metastases in colorectal
cancer: a SEER based study. Oncotarget 2015;6:38658-38666. Available
202. Taylor FG, Quirke P, Heald RJ, et al. Preoperative magnetic at: https://www.ncbi.nlm.nih.gov/pubmed/26484417.
resonance imaging assessment of circumferential resection margin
predicts disease-free survival and local recurrence: 5-year follow-up 210. Hayashi M, Inoue Y, Komeda K, et al. Clinicopathological analysis of
results of the MERCURY study. J Clin Oncol 2014;32:34-43. Available at: recurrence patterns and prognostic factors for survival after hepatectomy
http://www.ncbi.nlm.nih.gov/pubmed/24276776. for colorectal liver metastasis. BMC Surg 2010;10:27. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/20875094.
203. Faletti R, Gatti M, Arezzo A, et al. Preoperative staging of rectal
cancer using magnetic resonance imaging: comparison with pathological 211. Muratore A, Zorzi D, Bouzari H, et al. Asymptomatic colorectal cancer
staging. Minerva Chir 2018;73:13-19. Available at: with un-resectable liver metastases: immediate colorectal resection or up-
https://www.ncbi.nlm.nih.gov/pubmed/28497665. front systemic chemotherapy? Ann Surg Oncol 2007;14:766-770.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/17103261.
204. Bipat S, Glas AS, Slors FJM, et al. Rectal cancer: local staging and
assessment of lymph node involvement with endoluminal US, CT, and MR 212. de Jong EA, Ten Berge JC, Dwarkasing RS, et al. The accuracy of
imaging--a meta-analysis. Radiology 2004;232:773-783. Available at: MRI, endorectal ultrasonography, and computed tomography in predicting
http://www.ncbi.nlm.nih.gov/pubmed/15273331. the response of locally advanced rectal cancer after preoperative therapy:

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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a metaanalysis. Surgery 2016;159:688-699. Available at: meta-analysis. Radiology 2013;269:101-112. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/26619929. http://www.ncbi.nlm.nih.gov/pubmed/23801777.

213. Dickman R, Kundel Y, Levy-Drummer R, et al. Restaging locally 220. Zhao RS, Wang H, Zhou ZY, et al. Restaging of locally advanced
advanced rectal cancer by different imaging modalities after preoperative rectal cancer with magnetic resonance imaging and endoluminal
chemoradiation: a comparative study. Radiat Oncol 2013;8:278. Available ultrasound after preoperative chemoradiotherapy: a systemic review and
at: http://www.ncbi.nlm.nih.gov/pubmed/24286200. meta-analysis. Dis Colon Rectum 2014;57:388-395. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24509465.
214. Guillem JG, Ruby JA, Leibold T, et al. Neither FDG-PET Nor CT can
distinguish between a pathological complete response and an incomplete 221. Park HJ, Jang JK, Park SH, et al. Restaging abdominopelvic
response after neoadjuvant chemoradiation in locally advanced rectal computed tomography before surgery after preoperative
cancer: a prospective study. Ann Surg 2013;258:289-295. Available at: chemoradiotherapy in patients with locally advanced rectal cancer. JAMA
http://www.ncbi.nlm.nih.gov/pubmed/23187748. Oncol 2018;4:259-262. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/29181529.
215. Hanly AM, Ryan EM, Rogers AC, et al. Multicenter Evaluation of
Rectal cancer ReImaging pOst Neoadjuvant (MERRION) therapy. Ann 222. Hotker AM, Garcia-Aguilar J, Gollub MJ. Multiparametric MRI of
Surg 2014;259:723-727. Available at: rectal cancer in the assessment of response to therapy: a systematic
http://www.ncbi.nlm.nih.gov/pubmed/23744576. review. Dis Colon Rectum 2014;57:790-799. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24807605.
216. Kuo LJ, Chiou JF, Tai CJ, et al. Can we predict pathologic complete
response before surgery for locally advanced rectal cancer treated with 223. Joye I, Deroose CM, Vandecaveye V, Haustermans K. The role of
preoperative chemoradiation therapy? Int J Colorectal Dis 2012;27:613- diffusion-weighted MRI and (18)F-FDG PET/CT in the prediction of
621. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22080392. pathologic complete response after radiochemotherapy for rectal cancer: a
systematic review. Radiother Oncol 2014;113:158-165. Available at:
217. Memon S, Lynch AC, Bressel M, et al. Systematic review and meta- https://www.ncbi.nlm.nih.gov/pubmed/25483833.
analysis of the accuracy of MRI and endorectal ultrasound in the restaging
and response assessment of rectal cancer following neoadjuvant therapy. 224. Lambregts DM, Rao SX, Sassen S, et al. MRI and diffusion-weighted
Colorectal Dis 2015;17:748-761. Available at: MRI molumetry for identification of complete tumor responders after
http://www.ncbi.nlm.nih.gov/pubmed/25891148. preoperative chemoradiotherapy in patients with rectal cancer: a bi-
institutional validation study. Ann Surg 2015;262:1034-1039. Available at:
218. Ryan JE, Warrier SK, Lynch AC, Heriot AG. Assessing pathological https://www.ncbi.nlm.nih.gov/pubmed/25211270.
complete response to neoadjuvant chemoradiotherapy in locally advanced
rectal cancer: a systematic review. Colorectal Dis 2015;17:849-861. 225. Memon S, Lynch AC, Akhurst T, et al. Systematic review of FDG-
Available at: http://www.ncbi.nlm.nih.gov/pubmed/26260213. PET prediction of complete pathological response and survival in rectal
cancer. Ann Surg Oncol 2014;21:3598-3607. Available at:
219. van der Paardt MP, Zagers MB, Beets-Tan RG, et al. Patients who https://www.ncbi.nlm.nih.gov/pubmed/24802909.
undergo preoperative chemoradiotherapy for locally advanced rectal
cancer restaged by using diagnostic MR imaging: a systematic review and

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NCCN Guidelines Version 4.2024

Rectal Cancer

226. Guillem JG, Cohen AM. Current issues in colorectal cancer surgery. 2007;245:726-733. Available at:
Semin Oncol 1999;26:505-513. Available at: http://www.ncbi.nlm.nih.gov/pubmed/17457165.
http://www.ncbi.nlm.nih.gov/pubmed/10528898.
234. van Oostendorp SE, Smits LJH, Vroom Y, et al. Local recurrence
227. Lindsetmo RO, Joh YG, Delaney CP. Surgical treatment for rectal after local excision of early rectal cancer: a meta-analysis of completion
cancer: an international perspective on what the medical TME, adjuvant (chemo)radiation, or no additional treatment. Br J Surg
gastroenterologist needs to know. World J Gastroenterol 2008;14:3281- 2020;107:1719-1730. Available at:
3289. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18528924. https://www.ncbi.nlm.nih.gov/pubmed/32936943.

228. Willett CG, Compton CC, Shellito PC, Efird JT. Selection factors for 235. Garcia-Aguilar J, Renfro LA, Chow OS, et al. Organ preservation for
local excision or abdominoperineal resection of early stage rectal cancer. clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy
Cancer 1994;73:2716-2720. Available at: and local excision (ACOSOG Z6041): results of an open-label, single-arm,
http://www.ncbi.nlm.nih.gov/pubmed/8194011. multi-institutional, phase 2 trial. Lancet Oncol 2015;16:1537-1546.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/26474521.
229. Clancy C, Burke JP, Albert MR, et al. Transanal endoscopic
microsurgery versus standard transanal excision for the removal of rectal 236. Shaikh I, Askari A, Ouru S, et al. Oncological outcomes of local
neoplasms: a systematic review and meta-analysis. Dis Colon Rectum excision compared with radical surgery after neoadjuvant
2015;58:254-261. Available at: chemoradiotherapy for rectal cancer: a systematic review and meta-
http://www.ncbi.nlm.nih.gov/pubmed/25585086. analysis. Int J Colorectal Dis 2015;30:19-29. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/25367179.
230. Chen Y, Guo R, Xie J, et al. Laparoscopy combined with transanal
endoscopic microsurgery for rectal cancer: A prospective, single-blinded, 237. Landmann RG, Wong WD, Hoepfl J, et al. Limitations of early rectal
randomized clinical trial. Surg Laparosc Endosc Percutan Tech cancer nodal staging may explain failure after local excision. Dis Colon
2015;25:399-402. Available at: Rectum 2007;50:1520-1525. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/26429049. http://www.ncbi.nlm.nih.gov/pubmed/17674104.

231. Nascimbeni R, Burgart LJ, Nivatvongs S, Larson DR. Risk of lymph 238. Kidane B, Chadi SA, Kanters S, et al. Local resection compared with
node metastasis in T1 carcinoma of the colon and rectum. Dis Colon radical resection in the treatment of T1N0M0 rectal adenocarcinoma: a
Rectum 2002;45:200-206. Available at: systematic review and meta-analysis. Dis Colon Rectum 2015;58:122-140.
http://www.ncbi.nlm.nih.gov/pubmed/11852333. Available at: http://www.ncbi.nlm.nih.gov/pubmed/25489704.

232. Yamamoto S, Watanabe M, Hasegawa H, et al. The risk of lymph 239. Nash GM, Weiser MR, Guillem JG, et al. Long-term survival after
node metastasis in T1 colorectal carcinoma. Hepatogastroenterology transanal excision of T1 rectal cancer. Dis Colon Rectum 2009;52:577-
2004;51:998-1000. Available at: 582. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19404055.
http://www.ncbi.nlm.nih.gov/pubmed/15239233.
240. Stitzenberg KB, Sanoff HK, Penn DC, et al. Practice patterns and
233. You YN, Baxter NN, Stewart A, Nelson H. Is the increasing rate of long-term survival for early-stage rectal cancer. J Clin Oncol
local excision for stage I rectal cancer in the United States justified?: a 2013;31:4276-4282. Available at:
nationwide cohort study from the National Cancer Database. Ann Surg http://www.ncbi.nlm.nih.gov/pubmed/24166526.

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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NCCN Guidelines Version 4.2024

Rectal Cancer

241. Sajid MS, Farag S, Leung P, et al. Systematic review and meta- 249. Negoi I, Hostiuc S, Paun S, et al. Extralevator vs conventional
analysis of published trials comparing the effectiveness of transanal abdominoperineal resection for rectal cancer-A systematic review and
endoscopic microsurgery and radical resection in the management of early meta-analysis. Am J Surg 2016;212:511-526. Available at:
rectal cancer. Colorectal Dis 2014;16:2-14. Available at: https://www.ncbi.nlm.nih.gov/pubmed/27317475.
http://www.ncbi.nlm.nih.gov/pubmed/24330432.
250. Nagtegaal ID, van de Velde CJ, van der Worp E, et al. Macroscopic
242. Lu JY, Lin GL, Qiu HZ, et al. Comparison of transanal endoscopic evaluation of rectal cancer resection specimen: clinical significance of the
microsurgery and total mesorectal excision in the treatment of T1 rectal pathologist in quality control. J Clin Oncol 2002;20:1729-1734. Available
cancer: a meta-analysis. PLoS One 2015;10:e0141427. Available at: at: http://www.ncbi.nlm.nih.gov/pubmed/11919228.
http://www.ncbi.nlm.nih.gov/pubmed/26505895.
251. Parfitt JR, Driman DK. The total mesorectal excision specimen for
243. Heald RJ, Husband EM, Ryall RD. The mesorectum in rectal cancer rectal cancer: a review of its pathological assessment. J Clin Pathol
surgery--the clue to pelvic recurrence? Br J Surg 1982;69:613-616. 2007;60:849-855. Available at:
Available at: http://www.ncbi.nlm.nih.gov/pubmed/6751457. http://www.ncbi.nlm.nih.gov/pubmed/17046842.

244. Steup WH, Moriya Y, van de Velde CJH. Patterns of lymphatic 252. den Dulk M, Putter H, Collette L, et al. The abdominoperineal
spread in rectal cancer. A topographical analysis on lymph node resection itself is associated with an adverse outcome: the European
metastases. Eur J Cancer 2002;38:911-918. Available at: experience based on a pooled analysis of five European randomised
http://www.ncbi.nlm.nih.gov/pubmed/11978516. clinical trials on rectal cancer. Eur J Cancer 2009;45:1175-1183. Available
at: http://www.ncbi.nlm.nih.gov/pubmed/19128956.
245. Schlag PM. Surgical sphincter preservation in rectal cancer.
Oncologist 1996;1:288-292. Available at: 253. Pahlman L, Bohe M, Cedermark B, et al. The Swedish rectal cancer
http://www.ncbi.nlm.nih.gov/pubmed/10388006. registry. Br J Surg 2007;94:1285-1292. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/17661309.
246. Marr R, Birbeck K, Garvican J, et al. The modern abdominoperineal
excision: the next challenge after total mesorectal excision. Ann Surg 254. Digennaro R, Tondo M, Cuccia F, et al. Coloanal anastomosis or
2005;242:74-82. Available at: abdominoperineal resection for very low rectal cancer: what will benefit,
http://www.ncbi.nlm.nih.gov/pubmed/15973104. the surgeon's pride or the patient's quality of life? Int J Colorectal Dis
2013;28:949-957. Available at:
247. Russell MM, Ganz PA, Lopa S, et al. Comparative effectiveness of http://www.ncbi.nlm.nih.gov/pubmed/23274737.
sphincter-sparing surgery versus abdominoperineal resection in rectal
cancer: patient-reported outcomes in National Surgical Adjuvant Breast 255. Pachler J, Wille-Jorgensen P. Quality of life after rectal resection for
and Bowel Project randomized trial R-04. Ann Surg 2015;261:144-148. cancer, with or without permanent colostomy. Cochrane Database Syst
Available at: http://www.ncbi.nlm.nih.gov/pubmed/24670844. Rev 2012;12:CD004323. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/23235607.
248. Huang A, Zhao H, Ling T, et al. Oncological superiority of extralevator
abdominoperineal resection over conventional abdominoperineal 256. Bonjer HJ, Deijen CL, Abis GA, et al. A randomized trial of
resection: a meta-analysis. Int J Colorectal Dis 2014;29:321-327. Available laparoscopic versus open surgery for rectal cancer. N Engl J Med
at: http://www.ncbi.nlm.nih.gov/pubmed/24385025.

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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2015;372:1324-1332. Available at: versus open surgery for colorectal cancer. Br J Surg 2010;97:1638-1645.
http://www.ncbi.nlm.nih.gov/pubmed/25830422. Available at: http://www.ncbi.nlm.nih.gov/pubmed/20629110.

257. Jeong SY, Park JW, Nam BH, et al. Open versus laparoscopic 264. Kang SB, Park JW, Jeong SY, et al. Open versus laparoscopic
surgery for mid-rectal or low-rectal cancer after neoadjuvant surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy
chemoradiotherapy (COREAN trial): survival outcomes of an open-label, (COREAN trial): short-term outcomes of an open-label randomised
non-inferiority, randomised controlled trial. Lancet Oncol 2014;15:767-774. controlled trial. Lancet Oncol 2010;11:637-645. Available at:
Available at: http://www.ncbi.nlm.nih.gov/pubmed/24837215. http://www.ncbi.nlm.nih.gov/pubmed/20610322.

258. Fleshman J, Branda M, Sargent DJ, et al. Effect of laparoscopic- 265. Wagman LD. Laparoscopic and open surgery for colorectal cancer:
assisted resection vs open resection of stage II or III rectal cancer on reaching equipoise? J Clin Oncol 2007;25:2996-2998. Available at:
pathologic outcomes: the ACOSOG Z6051 randomized clinical trial. JAMA http://www.ncbi.nlm.nih.gov/pubmed/17634477.
2015;314:1346-1355. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/26441179. 266. Fleshman J, Branda ME, Sargent DJ, et al. Disease-free Survival and
Local Recurrence for Laparoscopic Resection Compared With Open
259. Stevenson AR, Solomon MJ, Lumley JW, et al. Effect of Resection of Stage II to III Rectal Cancer: Follow-up Results of the
laparoscopic-assisted resection vs open resection on pathological ACOSOG Z6051 Randomized Controlled Trial. Ann Surg 2019;269:589-
outcomes in rectal cancer: the ALaCaRT randomized clinical trial. JAMA 595. Available at: https://pubmed.ncbi.nlm.nih.gov/30080730/.
2015;314:1356-1363. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/26441180. 267. Stevenson ARL, Solomon MJ, Brown CSB, et al. Disease-free
Survival and Local Recurrence After Laparoscopic-assisted Resection or
260. Lujan J, Valero G, Biondo S, et al. Laparoscopic versus open surgery Open Resection for Rectal Cancer: The Australasian Laparoscopic Cancer
for rectal cancer: results of a prospective multicentre analysis of 4,970 of the Rectum Randomized Clinical Trial. Ann Surg 2019;269:596-602.
patients. Surg Endosc 2013;27:295-302. Available at: Available at: https://pubmed.ncbi.nlm.nih.gov/30247332/.
http://www.ncbi.nlm.nih.gov/pubmed/22736289.
268. Nussbaum DP, Speicher PJ, Ganapathi AM, et al. Laparoscopic
261. van der Pas MH, Haglind E, Cuesta MA, et al. Laparoscopic versus versus open low anterior resection for rectal cancer: results from the
open surgery for rectal cancer (COLOR II): short-term outcomes of a National Cancer Data Base. J Gastrointest Surg 2014;19:124-131;
randomised, phase 3 trial. Lancet Oncol 2013;14:210-218. Available at: discussion 131-122. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/23395398. http://www.ncbi.nlm.nih.gov/pubmed/25091847.

262. Jayne DG, Guillou PJ, Thorpe H, et al. Randomized trial of 269. Araujo SE, da Silva eSousa AH, Jr., de Campos FG, et al.
laparoscopic-assisted resection of colorectal carcinoma: 3-year results of Conventional approach x laparoscopic abdominoperineal resection for
the UK MRC CLASICC Trial Group. J Clin Oncol 2007;25:3061-3068. rectal cancer treatment after neoadjuvant chemoradiation: results of a
Available at: http://www.ncbi.nlm.nih.gov/pubmed/17634484. prospective randomized trial. Rev Hosp Clin Fac Med Sao Paulo
2003;58:133-140. Available at:
263. Jayne DG, Thorpe HC, Copeland J, et al. Five-year follow-up of the http://www.ncbi.nlm.nih.gov/pubmed/12894309.
Medical Research Council CLASICC trial of laparoscopically assisted

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NCCN Guidelines Version 4.2024

Rectal Cancer

270. Gopall J, Shen XF, Cheng Y. Current status of laparoscopic total and long-term outcomes. J Gastrointest Surg 2015;19:1497-1512.
mesorectal excision. Am J Surg 2012;203:230-241. Available at: Available at: http://www.ncbi.nlm.nih.gov/pubmed/26040854.
http://www.ncbi.nlm.nih.gov/pubmed/22269656.
278. Morneau M, Boulanger J, Charlebois P, et al. Laparoscopic versus
271. Kuhry E, Schwenk WF, Gaupset R, et al. Long-term results of open surgery for the treatment of colorectal cancer: a literature review and
laparoscopic colorectal cancer resection. Cochrane Database Syst Rev recommendations from the Comite de l'evolution des pratiques en
2008:CD003432. Available at: oncologie. Can J Surg 2013;56:297-310. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/18425886. http://www.ncbi.nlm.nih.gov/pubmed/24067514.

272. Lee JK, Delaney CP, Lipman JM. Current state of the art in 279. Ng SS, Lee JF, Yiu RY, et al. Long-term oncologic outcomes of
laparoscopic colorectal surgery for cancer: Update on the multi-centric laparoscopic versus open surgery for rectal cancer: a pooled analysis of 3
international trials. Ann Surg Innov Res 2012;6:5. Available at: randomized controlled trials. Ann Surg 2014;259:139-147. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/22846394. http://www.ncbi.nlm.nih.gov/pubmed/23598381.

273. Trastulli S, Cirocchi R, Listorti C, et al. Laparoscopic vs open 280. Vennix S, Pelzers L, Bouvy N, et al. Laparoscopic versus open total
resection for rectal cancer: a meta-analysis of randomized clinical trials. mesorectal excision for rectal cancer. Cochrane Database Syst Rev
Colorectal Dis 2012;14:e277-296. Available at: 2014;4:CD005200. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/22330061. http://www.ncbi.nlm.nih.gov/pubmed/24737031.

274. Xiong B, Ma L, Zhang C. Laparoscopic versus open total mesorectal 281. Zhang FW, Zhou ZY, Wang HL, et al. Laparoscopic versus open
excision for middle and low rectal cancer: a meta-analysis of results of surgery for rectal cancer: a systematic review and meta-analysis of
randomized controlled trials. J Laparoendosc Adv Surg Tech A randomized controlled trials. Asian Pac J Cancer Prev 2014;15:9985-
2012;22:674-684. Available at: 9996. Available at: http://www.ncbi.nlm.nih.gov/pubmed/25520140.
http://www.ncbi.nlm.nih.gov/pubmed/22881123.
282. Zhao D, Li Y, Wang S, Huang Z. Laparoscopic versus open surgery
275. Ahmad NZ, Racheva G, Elmusharaf H. A systematic review and for rectal cancer: a meta-analysis of 3-year follow-up outcomes. Int J
meta-analysis of randomized and non-randomized studies comparing Colorectal Dis 2016;31:805-811. Available at:
laparoscopic and open abdominoperineal resection for rectal cancer. http://www.ncbi.nlm.nih.gov/pubmed/26847617.
Colorectal Dis 2013;15:269-277. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/22958456. 283. Martinez-Perez A, Carra MC, Brunetti F, de'Angelis N. Pathologic
outcomes of laparoscopic vs open mesorectal excision for rectal cancer: A
276. Arezzo A, Passera R, Scozzari G, et al. Laparoscopy for rectal systematic review and meta-analysis. JAMA Surg 2017;152:e165665.
cancer reduces short-term mortality and morbidity: results of a systematic Available at: https://www.ncbi.nlm.nih.gov/pubmed/28196217.
review and meta-analysis. Surg Endosc 2013;27:1485-1502. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/23183871. 284. Huang YM, Huang YJ, Wei PL. Outcomes of robotic versus
laparoscopic surgery for mid and low rectal cancer after neoadjuvant
277. Jiang JB, Jiang K, Dai Y, et al. Laparoscopic versus open surgery for chemoradiation therapy and the effect of learning curve. Medicine
mid-low rectal cancer: a systematic review and meta-analysis on short- (Baltimore) 2017;96:e8171. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/28984767.

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NCCN Guidelines Version 4.2024

Rectal Cancer

285. Jayne D, Pigazzi A, Marshall H, et al. effect of robotic-assisted vs 292. Gunderson LL, Sargent DJ, Tepper JE, et al. Impact of T and N stage
conventional laparoscopic surgery on risk of conversion to open and treatment on survival and relapse in adjuvant rectal cancer: a pooled
laparotomy among patients undergoing resection for rectal cancer: The analysis. J Clin Oncol 2004;22:1785-1796. Available at:
ROLARR randomized clinical trial. JAMA 2017;318:1569-1580. Available http://www.ncbi.nlm.nih.gov/pubmed/15067027.
at: https://www.ncbi.nlm.nih.gov/pubmed/29067426.
293. Tepper JE, O'Connell M, Niedzwiecki D, et al. Adjuvant therapy in
286. Kim MJ, Park SC, Park JW, et al. Robot-assisted versus laparoscopic rectal cancer: analysis of stage, sex, and local control--final report of
surgery for rectal cancer: A phase II open label prospective randomized intergroup 0114. J Clin Oncol 2002;20:1744-1750. Available at:
controlled trial. Ann Surg 2018;267:243-251. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11919230.
https://www.ncbi.nlm.nih.gov/pubmed/28549014.
294. Guillem JG, Diaz-Gonzalez JA, Minsky BD, et al. cT3N0 rectal
287. Li X, Wang T, Yao L, et al. The safety and effectiveness of robot- cancer: potential overtreatment with preoperative chemoradiotherapy is
assisted versus laparoscopic TME in patients with rectal cancer: A meta- warranted. J Clin Oncol 2008;26:368-373. Available at:
analysis and systematic review. Medicine (Baltimore) 2017;96:e7585. http://www.ncbi.nlm.nih.gov/pubmed/18202411.
Available at: https://www.ncbi.nlm.nih.gov/pubmed/28723798.
295. Cercek A, Goodman KA, Hajj C, et al. Neoadjuvant chemotherapy
288. Prete FP, Pezzolla A, Prete F, et al. Robotic versus laparoscopic first, followed by chemoradiation and then surgery, in the management of
minimally invasive surgery for rectal cancer: A systematic review and locally advanced rectal cancer. J Natl Compr Canc Netw 2014;12:513-
meta-analysis of randomized controlled trials. Ann Surg 2018;267:1034- 519. Available at: http://www.ncbi.nlm.nih.gov/pubmed/24717570.
1046. Available at: https://www.ncbi.nlm.nih.gov/pubmed/28984644.
296. Chau I, Brown G, Cunningham D, et al. Neoadjuvant capecitabine
289. Miskovic D, Foster J, Agha A, et al. Standardization of laparoscopic and oxaliplatin followed by synchronous chemoradiation and total
total mesorectal excision for rectal cancer: a structured international expert mesorectal excision in magnetic resonance imaging-defined poor-risk
consensus. Ann Surg 2015;261:716-722. Available at: rectal cancer. J Clin Oncol 2006;24:668-674. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/25072446. http://www.ncbi.nlm.nih.gov/pubmed/16446339.

290. Peeters KC, van de Velde CJ, Leer JW, et al. Late side effects of 297. Fernandez-Martos C, Pericay C, Aparicio J, et al. Phase II,
short-course preoperative radiotherapy combined with total mesorectal randomized study of concomitant chemoradiotherapy followed by surgery
excision for rectal cancer: increased bowel dysfunction in irradiated and adjuvant capecitabine plus oxaliplatin (CAPOX) compared with
patients--a Dutch colorectal cancer group study. J Clin Oncol induction CAPOX followed by concomitant chemoradiotherapy and
2005;23:6199-6206. Available at: surgery in magnetic resonance imaging-defined, locally advanced rectal
http://www.ncbi.nlm.nih.gov/pubmed/16135487. cancer: Grupo cancer de recto 3 study. J Clin Oncol 2010;28:859-865.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/20065174.
291. Rahbari NN, Elbers H, Askoxylakis V, et al. Neoadjuvant radiotherapy
for rectal cancer: meta-analysis of randomized controlled trials. Ann Surg 298. Perez K, Safran H, Sikov W, et al. Complete neoadjuvant treatment
Oncol 2013;20:4169-4182. Available at: for rectal cancer: The Brown University Oncology Group CONTRE study.
http://www.ncbi.nlm.nih.gov/pubmed/24002536. Am J Clin Oncol 2014;40:283-287. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/25374145.

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NCCN Guidelines Version 4.2024

Rectal Cancer

299. Marechal R, Vos B, Polus M, et al. Short course chemotherapy 305. Conroy T, Bosset JF, Etienne PL, et al. Neoadjuvant chemotherapy
followed by concomitant chemoradiotherapy and surgery in locally with FOLFIRINOX and preoperative chemoradiotherapy for patients with
advanced rectal cancer: a randomized multicentric phase II study. Ann locally advanced rectal cancer (UNICANCER-PRODIGE 23): a
Oncol 2012;23:1525-1530. Available at: multicentre, randomised, open-label, phase 3 trial. Lancet Oncol
http://www.ncbi.nlm.nih.gov/pubmed/22039087. 2021;22:702-715. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/33862000.
300. Nogue M, Salud A, Vicente P, et al. Addition of bevacizumab to
XELOX induction therapy plus concomitant capecitabine-based 306. Petrelli F, Trevisan F, Cabiddu M, et al. Total Neoadjuvant Therapy in
chemoradiotherapy in magnetic resonance imaging-defined poor- Rectal Cancer: A Systematic Review and Meta-analysis of Treatment
prognosis locally advanced rectal cancer: the AVACROSS study. Outcomes. Ann Surg 2020;271:440-448. Available at:
Oncologist 2011;16:614-620. Available at: https://www.ncbi.nlm.nih.gov/pubmed/31318794.
http://www.ncbi.nlm.nih.gov/pubmed/21467148.
307. Kasi A, Abbasi S, Handa S, et al. Total Neoadjuvant Therapy vs
301. Fernandez-Martos C, Garcia-Albeniz X, Pericay C, et al. Standard Therapy in Locally Advanced Rectal Cancer: A Systematic
Chemoradiation, surgery and adjuvant chemotherapy versus induction Review and Meta-analysis. JAMA Netw Open 2020;3:e2030097. Available
chemotherapy followed by chemoradiation and surgery: long-term results at: https://www.ncbi.nlm.nih.gov/pubmed/33326026.
of the Spanish GCR-3 phase II randomized trialdagger. Ann Oncol
2015;26:1722-1728. Available at: 308. Cercek A, Roxburgh CSD, Strombom P, et al. Adoption of Total
http://www.ncbi.nlm.nih.gov/pubmed/25957330. Neoadjuvant Therapy for Locally Advanced Rectal Cancer. JAMA Oncol
2018;4:e180071. Available at:
302. Sclafani F, Brown G, Cunningham D, et al. PAN-EX: a pooled https://www.ncbi.nlm.nih.gov/pubmed/29566109.
analysis of two trials of neoadjuvant chemotherapy followed by
chemoradiotherapy in MRI-defined, locally advanced rectal cancer. Ann 309. Smith JJ, Chow OS, Gollub MJ, et al. Organ Preservation in Rectal
Oncol 2016;27:1557-1565. Available at: Adenocarcinoma: a phase II randomized controlled trial evaluating 3-year
https://www.ncbi.nlm.nih.gov/pubmed/27217542. disease-free survival in patients with locally advanced rectal cancer
treated with chemoradiation plus induction or consolidation chemotherapy,
303. Garcia-Aguilar J, Chow OS, Smith DD, et al. Effect of adding and total mesorectal excision or nonoperative management. BMC Cancer
mFOLFOX6 after neoadjuvant chemoradiation in locally advanced rectal 2015;15:767. Available at: https://pubmed.ncbi.nlm.nih.gov/26497495/.
cancer: a multicentre, phase 2 trial. Lancet Oncol 2015;16:957-966.
Available at: https://www.ncbi.nlm.nih.gov/pubmed/26187751. 310. Garcia-Aguilar J, Patil S, Gollub MJ, et al. Organ Preservation in
Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant
304. Bahadoer RR, Dijkstra EA, van Etten B, et al. Short-course Therapy. J Clin Oncol 2022;40:2546-2556. Available at:
radiotherapy followed by chemotherapy before total mesorectal excision https://www.ncbi.nlm.nih.gov/pubmed/35483010.
(TME) versus preoperative chemoradiotherapy, TME, and optional
adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a 311. Fokas E, Allgauer M, Polat B, et al. Randomized Phase II Trial of
randomised, open-label, phase 3 trial. Lancet Oncol 2021;22:29-42. Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as
Available at: https://www.ncbi.nlm.nih.gov/pubmed/33301740. Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer:
CAO/ARO/AIO-12. J Clin Oncol 2019;37:3212-3222. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/31150315.

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NCCN Guidelines Version 4.2024

Rectal Cancer

312. Fokas E, Schlenska-Lange A, Polat B, et al. Chemoradiotherapy Plus Radiother Oncol 2006;80:4-12. Available at:
Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy http://www.ncbi.nlm.nih.gov/pubmed/16730086.
for Patients With Locally Advanced Rectal Cancer: Long-term Results of
the CAO/ARO/AIO-12 Randomized Clinical Trial. JAMA Oncol 319. Wong RK, Tandan V, De Silva S, Figueredo A. Pre-operative
2022;8:e215445. Available at: radiotherapy and curative surgery for the management of localized rectal
https://www.ncbi.nlm.nih.gov/pubmed/34792531. carcinoma. Cochrane Database Syst Rev 2007:CD002102. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/17443515.
313. Zhang J, Huang M, Cai Y, et al. Neoadjuvant Chemotherapy With
mFOLFOXIRI Without Routine Use of Radiotherapy for Locally Advanced 320. Gerard JP, Conroy T, Bonnetain F, et al. Preoperative radiotherapy
Rectal Cancer. Clin Colorectal Cancer 2019;18:238-244. Available at: with or without concurrent fluorouracil and leucovorin in T3-4 rectal
https://pubmed.ncbi.nlm.nih.gov/31378655/. cancers: results of FFCD 9203. J Clin Oncol 2006;24:4620-4625.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/17008704.
314. Masi G, Vivaldi C, Fornaro L, et al. Total neoadjuvant approach with
FOLFOXIRI plus bevacizumab followed by chemoradiotherapy plus 321. Bosset JF, Calais G, Mineur L, et al. Enhanced tumorocidal effect of
bevacizumab in locally advanced rectal cancer: the TRUST trial. Eur J chemotherapy with preoperative radiotherapy for rectal cancer: preliminary
Cancer 2019;110:32-41. Available at: results--EORTC 22921. J Clin Oncol 2005;23:5620-5627. Available at:
https://pubmed.ncbi.nlm.nih.gov/30739838/. http://www.ncbi.nlm.nih.gov/pubmed/16009958.

315. Sauer R, Becker H, Hohenberger W, et al. Preoperative versus 322. Bosset JF, Collette L, Calais G, et al. Chemotherapy with
postoperative chemoradiotherapy for rectal cancer. N Engl J Med preoperative radiotherapy in rectal cancer. N Engl J Med 2006;355:1114-
2004;351:1731-1740. Available at: 1123. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16971718.
http://www.ncbi.nlm.nih.gov/pubmed/15496622.
323. Ceelen WP, Van Nieuwenhove Y, Fierens K. Preoperative
316. Sauer R, Liersch T, Merkel S, et al. Preoperative versus chemoradiation versus radiation alone for stage II and III resectable rectal
postoperative chemoradiotherapy for locally advanced rectal cancer: cancer. Cochrane Database Syst Rev 2009:CD006041. Available at:
results of the German CAO/ARO/AIO-94 randomized phase III trial after a http://www.ncbi.nlm.nih.gov/pubmed/19160264.
median follow-up of 11 years. J Clin Oncol 2012;30:1926-1933. Available
at: http://www.ncbi.nlm.nih.gov/pubmed/22529255. 324. McCarthy K, Pearson K, Fulton R, Hewitt J. Pre-operative
chemoradiation for non-metastatic locally advanced rectal cancer.
317. Wagman R, Minsky BD, Cohen AM, et al. Sphincter preservation in Cochrane Database Syst Rev 2012;12:CD008368. Available at:
rectal cancer with preoperative radiation therapy and coloanal http://www.ncbi.nlm.nih.gov/pubmed/23235660.
anastomosis: long term follow-up. Int J Radiat Oncol Biol Phys
1998;42:51-57. Available at: 325. De Caluwe L, Van Nieuwenhove Y, Ceelen WP. Preoperative
http://www.ncbi.nlm.nih.gov/pubmed/9747819. chemoradiation versus radiation alone for stage II and III resectable rectal
cancer. Cochrane Database Syst Rev 2013;2:CD006041. Available at:
318. Bujko K, Kepka L, Michalski W, Nowacki MP. Does rectal cancer http://www.ncbi.nlm.nih.gov/pubmed/23450565.
shrinkage induced by preoperative radio(chemo)therapy increase the
likelihood of anterior resection? A systematic review of randomised trials. 326. Smalley SR, Benedetti JK, Williamson SK, et al. Phase III trial of
fluorouracil-based chemotherapy regimens plus radiotherapy in

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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Rectal Cancer

postoperative adjuvant rectal cancer: GI INT 0144. J Clin Oncol 333. Azria D, Doyen J, Jarlier M, et al. Late toxicities and clinical outcome
2006;24:3542-3547. Available at: at 5 years of the ACCORD 12/0405-PRODIGE 02 trial comparing two
http://www.ncbi.nlm.nih.gov/pubmed/16877719. neoadjuvant chemoradiotherapy regimens for intermediate-risk rectal
cancer. Ann Oncol 2017;28:2436-2442. Available at:
327. O'Connell MJ, Martenson JA, Wieand HS, et al. Improving adjuvant https://www.ncbi.nlm.nih.gov/pubmed/28961836.
therapy for rectal cancer by combining protracted-infusion fluorouracil with
radiation therapy after curative surgery. N Engl J Med 1994;331:502-507. 334. Schmoll HJ, Stein A, Van Cutsem E, et al. Pre- and Postoperative
Available at: http://www.ncbi.nlm.nih.gov/pubmed/8041415. Capecitabine Without or With Oxaliplatin in Locally Advanced Rectal
Cancer: PETACC 6 Trial by EORTC GITCG and ROG, AIO, AGITG,
328. Hofheinz RD, Wenz F, Post S, et al. Chemoradiotherapy with BGDO, and FFCD. J Clin Oncol 2021;39:17-29. Available at:
capecitabine versus fluorouracil for locally advanced rectal cancer: a https://www.ncbi.nlm.nih.gov/pubmed/33001764.
randomised, multicentre, non-inferiority, phase 3 trial. Lancet Oncol
2012;13:579-588. Available at: 335. Rodel C, Graeven U, Fietkau R, et al. Oxaliplatin added to
http://www.ncbi.nlm.nih.gov/pubmed/22503032. fluorouracil-based preoperative chemoradiotherapy and postoperative
chemotherapy of locally advanced rectal cancer (the German
329. O'Connell MJ, Colangelo LH, Beart RW, et al. Capecitabine and CAO/ARO/AIO-04 study): final results of the multicentre, open-label,
oxaliplatin in the preoperative multimodality treatment of rectal cancer: randomised, phase 3 trial. Lancet Oncol 2015;16:979-989. Available at:
surgical end points from National Surgical Adjuvant Breast and Bowel http://www.ncbi.nlm.nih.gov/pubmed/26189067.
Project trial R-04. J Clin Oncol 2014;32:1927-1934. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24799484. 336. Rodel C, Liersch T, Becker H, et al. Preoperative chemoradiotherapy
and postoperative chemotherapy with fluorouracil and oxaliplatin versus
330. Allegra CJ, Yothers G, O'Connell MJ, et al. Neoadjuvant 5-FU or fluorouracil alone in locally advanced rectal cancer: initial results of the
capecitabine plus radiation with or without oxaliplatin in rectal cancer German CAO/ARO/AIO-04 randomised phase 3 trial. Lancet Oncol
patients: a phase III randomized clinical trial. J Natl Cancer Inst 2012;13:679-687. Available at:
2015;107:djv248. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22627104.
http://www.ncbi.nlm.nih.gov/pubmed/26374429.
337. Glynne-Jones R. Rectal cancer--the times they are a-changing.
331. Aschele C, Cionini L, Lonardi S, et al. Primary tumor response to Lancet Oncol 2012;13:651-653. Available at:
preoperative chemoradiation with or without oxaliplatin in locally advanced http://www.ncbi.nlm.nih.gov/pubmed/22627103.
rectal cancer: pathologic results of the STAR-01 randomized phase III trial.
J Clin Oncol 2011;29:2773-2780. Available at: 338. Deng Y, Chi P, Lan P, et al. Modified FOLFOX6 with or without
http://www.ncbi.nlm.nih.gov/pubmed/21606427. radiation versus fluorouracil and leucovorin with radiation in neoadjuvant
treatment of locally advanced rectal cancer: initial results of the Chinese
332. Gerard JP, Azria D, Gourgou-Bourgade S, et al. Clinical outcome of FOWARC multicenter, open-label, randomized three-arm phase III trial. J
the ACCORD 12/0405 PRODIGE 2 randomized trial in rectal cancer. J Clin Oncol 2016;34:3300-3307. Available at:
Clin Oncol 2012;30:4558-4565. Available at: https://www.ncbi.nlm.nih.gov/pubmed/27480145.
http://www.ncbi.nlm.nih.gov/pubmed/23109696.
339. Deng Y, Chi P, Lan P, et al. Neoadjuvant Modified FOLFOX6 With or
Without Radiation Versus Fluorouracil Plus Radiation for Locally

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Rectal Cancer

Advanced Rectal Cancer: Final Results of the Chinese FOWARC Trial. J 346. Landry JC, Feng Y, Prabhu RS, et al. Phase II trial of preoperative
Clin Oncol 2019;37:3223-3233. Available at: radiation with concurrent capecitabine, oxaliplatin, and bevacizumab
https://pubmed.ncbi.nlm.nih.gov/31557064/. followed by surgery and postoperative 5-fluorouracil, leucovorin, oxaliplatin
(FOLFOX), and bevacizumab in patients with locally advanced rectal
340. Feng YR, Zhu Y, Liu LY, et al. Interim analysis of postoperative cancer: 5-year clinical outcomes ECOG-ACRIN Cancer Research Group
chemoradiotherapy with capecitabine and oxaliplatin versus capecitabine E3204. Oncologist 2015;20:615-616. Available at:
alone for pathological stage II and III rectal cancer: a randomized http://www.ncbi.nlm.nih.gov/pubmed/25926352.
multicenter phase III trial. Oncotarget 2016;7:25576-25584. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/27014909. 347. Borg C, Mantion G, Boudghène F, et al. Efficacy and Safety of Two
Neoadjuvant Strategies With Bevacizumab in MRI-Defined Locally
341. Dewdney A, Cunningham D, Tabernero J, et al. Multicenter Advanced T3 Resectable Rectal Cancer: Final Results of a Randomized,
randomized phase II clinical trial comparing neoadjuvant oxaliplatin, Noncomparative Phase 2 INOVA Study. Clin Colorectal Cancer
capecitabine, and preoperative radiotherapy with or without cetuximab 2019;18:200-208.e201. Available at:
followed by total mesorectal excision in patients with high-risk rectal https://pubmed.ncbi.nlm.nih.gov/31311761/.
cancer (EXPERT-C). J Clin Oncol 2012;30:1620-1627. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/22473163. 348. Maeda K, Shibutani M, Otani H, et al. Neoadjuvant Radiotherapy with
Capecitabine Plus Bevacizumab for Locally Advanced Lower Rectal
342. Eisterer W, De Vries A, Ofner D, et al. Preoperative treatment with Cancer: Results of a Single-institute Phase II Study. Anticancer Res
capecitabine, cetuximab and radiotherapy for primary locally advanced 2018;38:4193-4197. Available at:
rectal cancer--a phase II clinical trial. Anticancer Res 2014;34:6767-6773. https://pubmed.ncbi.nlm.nih.gov/29970549/.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/25368289.
349. Spigel DR, Bendell JC, McCleod M, et al. Phase II study of
343. Kripp M, Horisberger K, Mai S, et al. Does the addition of cetuximab bevacizumab and chemoradiation in the preoperative or adjuvant
to radiochemotherapy improve outcome of patients with locally advanced treatment of patients with stage II/III rectal cancer. Clin Colorectal Cancer
rectal cancer? Long-term results from phase II trials. Gastroenterol Res 2012;11:45-52. Available at:
Pract 2015;2015:273489. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21840771.
http://www.ncbi.nlm.nih.gov/pubmed/25861256.
350. Fernández-Martos C, Pericay C, Losa F, et al. Effect of Aflibercept
344. Helbling D, Bodoky G, Gautschi O, et al. Neoadjuvant Plus Modified FOLFOX6 Induction Chemotherapy Before Standard
chemoradiotherapy with or without panitumumab in patients with wild-type Chemoradiotherapy and Surgery in Patients With High-Risk Rectal
KRAS, locally advanced rectal cancer (LARC): a randomized, multicenter, Adenocarcinoma: The GEMCAD 1402 Randomized Clinical Trial. JAMA
phase II trial SAKK 41/07. Ann Oncol 2013;24:718-725. Available at: Oncol 2019;5:1566-1573. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/23139259. https://pubmed.ncbi.nlm.nih.gov/31465088/.
345. Pinto C, Di Bisceglie M, Di Fabio F, et al. Phase II study of 351. Bendell JC, Thompson D, Hemphill BM, et al. A Phase 2 Study of 5-
preoperative treatment with external radiotherapy plus panitumumab in Fluorouracil (5-FU), Ziv-Aflibercept, and Radiation for the Preoperative
low-risk, locally advanced rectal cancer (RaP Study/STAR-03). Oncologist and Adjuvant Treatment of Patients with Stage II/III Rectal Cancer. Cancer
2018;23:912-918. Available at: Invest 2017;35:535-540. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/29523646. https://pubmed.ncbi.nlm.nih.gov/28792245/.

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Rectal Cancer

352. Schrag D, Weiser MR, Goodman KA, et al. Neoadjuvant 359. Habr-Gama A, Perez RO, Proscurshim I, et al. Interval between
chemotherapy without routine use of radiation therapy for patients with surgery and neoadjuvant chemoradiation therapy for distal rectal cancer:
locally advanced rectal cancer: a pilot trial. J Clin Oncol 2014;32:513-518. does delayed surgery have an impact on outcome? Int J Radiat Oncol Biol
Available at: http://www.ncbi.nlm.nih.gov/pubmed/24419115. Phys 2008;71:1181-1188. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/18234443.
353. Hasegawa S, Goto S, Matsumoto T, et al. A multicenter phase 2
study on the feasibility and efficacy of neoadjuvant chemotherapy without 360. Moore HG, Gittleman AE, Minsky BD, et al. Rate of pathologic
radiotherapy for locally advanced rectal cancer. Ann Surg Oncol complete response with increased interval between preoperative
2017;24:3587-3595. Available at: combined modality therapy and rectal cancer resection. Dis Colon Rectum
https://www.ncbi.nlm.nih.gov/pubmed/28685354. 2004;47:279-286. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/14991488.
354. Jalil O, Claydon L, Arulampalam T. Review of neoadjuvant
chemotherapy alone in locally advanced rectal cancer. J Gastrointest 361. Petrelli F, Sgroi G, Sarti E, Barni S. Increasing the interval between
Cancer 2015;46:219-236. Available at: neoadjuvant chemoradiotherapy and surgery in rectal cancer: a meta-
https://www.ncbi.nlm.nih.gov/pubmed/26133151. analysis of published studies. Ann Surg 2016;263:458-464. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/24263329.
355. Cercek A, Lumish M, Sinopoli J, et al. PD-1 Blockade in Mismatch
Repair-Deficient, Locally Advanced Rectal Cancer. N Engl J Med 362. Sloothaak DA, Geijsen DE, van Leersum NJ, et al. Optimal time
2022;386:2363-2376. Available at: interval between neoadjuvant chemoradiotherapy and surgery for rectal
https://www.ncbi.nlm.nih.gov/pubmed/35660797. cancer. Br J Surg 2013;100:933-939. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/23536485.
356. Gay HA, Barthold HJ, O'Meara E, et al. Pelvic normal tissue
contouring guidelines for radiation therapy: a radiation therapy oncology 363. Tulchinsky H, Shmueli E, Figer A, et al. An interval >7 weeks
group consensus panel atlas. Int J Radiat Oncol Biol Phys 2012;83:e353- between neoadjuvant therapy and surgery improves pathologic complete
362. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22483697. response and disease-free survival in patients with locally advanced rectal
cancer. Ann Surg Oncol 2008;15:2661-2667. Available at:
357. Bae BK, Kang MK, Kim JC, et al. Simultaneous integrated boost http://www.ncbi.nlm.nih.gov/pubmed/18389322.
intensity-modulated radiotherapy versus 3-dimensional conformal
radiotherapy in preoperative concurrent chemoradiotherapy for locally 364. Probst CP, Becerra AZ, Aquina CT, et al. Extended intervals after
advanced rectal cancer. Radiat Oncol J 2017;35:208-216. Available at: neoadjuvant therapy in locally advanced rectal cancer: the key to
https://pubmed.ncbi.nlm.nih.gov/29037023/. improved tumor response and potential organ preservation. J Am Coll
Surg 2015;221:430-440. Available at:
358. Francois Y, Nemoz CJ, Baulieux J, et al. Influence of the interval http://www.ncbi.nlm.nih.gov/pubmed/26206642.
between preoperative radiation therapy and surgery on downstaging and
on the rate of sphincter-sparing surgery for rectal cancer: the Lyon R90-01 365. Huntington CR, Boselli D, Symanowski J, et al. Optimal timing of
randomized trial. J Clin Oncol 1999;17:2396. Available at: surgical resection after radiation in locally advanced rectal
http://www.ncbi.nlm.nih.gov/pubmed/10561302. adenocarcinoma: an analysis of the National Cancer Database. Ann Surg
Oncol 2016;23:877-887. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/26514119.

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NCCN Guidelines Version 4.2024

Rectal Cancer

366. Sun Z, Adam MA, Kim J, et al. Optimal timing to surgery after benefit in irradiated patients with resectable rectal carcinoma. Ann Surg
neoadjuvant chemoradiotherapy for locally advanced rectal cancer. J Am 2007;246:693-701. Available at:
Coll Surg 2016;222:367-374. Available at: http://www.ncbi.nlm.nih.gov/pubmed/17968156.
http://www.ncbi.nlm.nih.gov/pubmed/26897480.
374. Siegel R, Burock S, Wernecke KD, et al. Preoperative short-course
367. Gambacorta MA, Masciocchi C, Chiloiro G, et al. Timing to achieve radiotherapy versus combined radiochemotherapy in locally advanced
the highest rate of pCR after preoperative radiochemotherapy in rectal rectal cancer: a multi-centre prospectively randomised study of the Berlin
cancer: a pooled analysis of 3085 patients from 7 randomized trials. Cancer Society. BMC Cancer 2009;9:50. Available at:
Radiother Oncol 2021;154:154-160. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19200365.
https://www.ncbi.nlm.nih.gov/pubmed/32966845.
375. Sebag-Montefiore D, Stephens RJ, Steele R, et al. Preoperative
368. Lefevre JH, Mineur L, Kotti S, et al. Effect of interval (7 or 11 weeks) radiotherapy versus selective postoperative chemoradiotherapy in patients
between neoadjuvant radiochemotherapy and surgery on complete with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre,
pathologic response in rectal cancer: a multicenter, randomized, controlled randomised trial. Lancet 2009;373:811-820. Available at:
trial (GRECCAR-6). J Clin Oncol 2016;34:3773-3780. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19269519.
https://www.ncbi.nlm.nih.gov/pubmed/27432930.
376. Stephens RJ, Thompson LC, Quirke P, et al. Impact of short-course
369. Lefevre JH, Mineur L, Cachanado M, et al. Does A Longer Waiting preoperative radiotherapy for rectal cancer on patients' quality of life: data
Period After Neoadjuvant Radio-chemotherapy Improve the Oncological from the Medical Research Council CR07/National Cancer Institute of
Prognosis of Rectal Cancer?: Three Years' Follow-up Results of the Canada Clinical Trials Group C016 randomized clinical trial. J Clin Oncol
Greccar-6 Randomized Multicenter Trial. Ann Surg 2019;270:747-754. 2010;28:4233-4239. Available at:
Available at: https://www.ncbi.nlm.nih.gov/pubmed/31634178. http://www.ncbi.nlm.nih.gov/pubmed/20585099.

370. Improved survival with preoperative radiotherapy in resectable rectal 377. van Gijn W, Marijnen CA, Nagtegaal ID, et al. Preoperative
cancer. Swedish Rectal Cancer Trial. N Engl J Med 1997;336:980-987. radiotherapy combined with total mesorectal excision for resectable rectal
Available at: http://www.ncbi.nlm.nih.gov/pubmed/9091798. cancer: 12-year follow-up of the multicentre, randomised controlled TME
trial. Lancet Oncol 2011;12:575-582. Available at:
371. Birgisson H, Pahlman L, Gunnarsson U, Glimelius B. Adverse effects http://www.ncbi.nlm.nih.gov/pubmed/21596621.
of preoperative radiation therapy for rectal cancer: long-term follow-up of
the Swedish Rectal Cancer Trial. J Clin Oncol 2005;23:8697-8705. 378. Bujko K, Nowacki MP, Nasierowska-Guttmejer A, et al. Long-term
Available at: http://www.ncbi.nlm.nih.gov/pubmed/16314629. results of a randomized trial comparing preoperative short-course
radiotherapy with preoperative conventionally fractionated chemoradiation
372. Kapiteijn E, Marijnen CA, Nagtegaal ID, et al. Preoperative for rectal cancer. Br J Surg 2006;93:1215-1223. Available at:
radiotherapy combined with total mesorectal excision for resectable rectal http://www.ncbi.nlm.nih.gov/pubmed/16983741.
cancer. N Engl J Med 2001;345:638-646. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/11547717. 379. Ngan SY, Burmeister B, Fisher RJ, et al. Randomized trial of short-
course radiotherapy versus long-course chemoradiation comparing rates
373. Peeters KCMJ, Marijnen CAM, Nagtegaal ID, et al. The TME trial of local recurrence in patients with T3 rectal cancer: Trans-Tasman
after a median follow-up of 6 years: increased local control but no survival

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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Radiation Oncology Group trial 01.04. J Clin Oncol 2012;30:3827-3833. Polish II study. Ann Oncol 2019;30:1298-1303. Available at:
Available at: http://www.ncbi.nlm.nih.gov/pubmed/23008301. https://www.ncbi.nlm.nih.gov/pubmed/31192355.

380. Ansari N, Solomon MJ, Fisher RJ, et al. Acute Adverse Events and 386. van der Valk MJM, Marijnen CAM, van Etten B, et al. Compliance
Postoperative Complications in a Randomized Trial of Preoperative Short- and tolerability of short-course radiotherapy followed by preoperative
course Radiotherapy Versus Long-course Chemoradiotherapy for T3 chemotherapy and surgery for high-risk rectal cancer - Results of the
Adenocarcinoma of the Rectum: Trans-Tasman Radiation Oncology international randomized RAPIDO-trial. Radiother Oncol 2020;147:75-83.
Group Trial (TROG 01.04). Ann Surg 2017;265:882-888. Available at: Available at: https://www.ncbi.nlm.nih.gov/pubmed/32240909.
https://www.ncbi.nlm.nih.gov/pubmed/27631775.
387. Dijkstra EA, Hospers GAP, Kranenbarg EM, et al. Quality of life and
381. McLachlan SA, Fisher RJ, Zalcberg J, et al. The impact on health- late toxicity after short-course radiotherapy followed by chemotherapy or
related quality of life in the first 12 months: A randomised comparison of chemoradiotherapy for locally advanced rectal cancer - The RAPIDO trial.
preoperative short-course radiation versus long-course chemoradiation for Radiother Oncol 2022;171:69-76. Available at:
T3 rectal cancer (Trans-Tasman Radiation Oncology Group Trial 01.04). https://www.ncbi.nlm.nih.gov/pubmed/35447283.
Eur J Cancer 2016;55:15-26. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/26771873. 388. Bahadoer R, Dijkstra E. Patterns of locoregional failure and distant
metastases in patients treated for locally advanced rectal cancer in the
382. Latkauskas T, Pauzas H, Gineikiene I, et al. Initial results of a RAPIDO trial [abstract]. European Journal of Surgical Oncology
randomized controlled trial comparing clinical and pathological 2022;48:e34. Available at: https://doi.org/10.1016/j.ejso.2021.12.439.
downstaging of rectal cancer after preoperative short-course radiotherapy
or long-term chemoradiotherapy, both with delayed surgery. Colorectal Dis 389. Erlandsson J, Fuentes S, Radu C, et al. Radiotherapy regimens for
2012;14:294-298. Available at: rectal cancer: long-term outcomes and health-related quality of life in the
http://www.ncbi.nlm.nih.gov/pubmed/21899712. Stockholm III trial. BJS Open 2021;5. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/35040942.
383. Latkauskas T, Pauzas H, Kairevice L, et al. Preoperative
conventional chemoradiotherapy versus short-course radiotherapy with 390. Erlandsson J, Holm T, Pettersson D, et al. Optimal fractionation of
delayed surgery for rectal cancer: results of a randomized controlled trial. preoperative radiotherapy and timing to surgery for rectal cancer
BMC Cancer 2016;16:927. Available at: (Stockholm III): a multicentre, randomised, non-blinded, phase 3, non-
https://www.ncbi.nlm.nih.gov/pubmed/27903247. inferiority trial. Lancet Oncol 2017;18:336-346. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/28190762.
384. Bujko K, Wyrwicz L, Rutkowski A, et al. Long-course oxaliplatin-
based preoperative chemoradiation versus 5 x 5 Gy and consolidation 391. Jin J, Tang Y, Hu C, et al. Multicenter, Randomized, Phase III Trial of
chemotherapy for cT4 or fixed cT3 rectal cancer: results of a randomized Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term
phase III study. Ann Oncol 2016;27:834-842. Available at: Chemoradiotherapy in Locally Advanced Rectal Cancer (STELLAR). J Clin
https://www.ncbi.nlm.nih.gov/pubmed/26884592. Oncol 2022;40:1681-1692. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/35263150.
385. Cisel B, Pietrzak L, Michalski W, et al. Long-course preoperative
chemoradiation vs. 5 x 5 Gy and consolidation chemotherapy for clinical 392. Bujko K, Partycki M, Pietrzak L. Neoadjuvant radiotherapy (5 x 5 Gy):
T4 and fixed clinical T3 rectal cancer: Long-term results of the randomized immediate versus delayed surgery. Recent Results Cancer Res

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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Rectal Cancer

2014;203:171-187. Available at: preoperative chemoradiation. Ann Surg 2010;251:261-264. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/25103005. http://www.ncbi.nlm.nih.gov/pubmed/19864936.

393. Collette L, Bosset J-F, den Dulk M, et al. Patients with curative 400. Patel UB, Taylor F, Blomqvist L, et al. Magnetic resonance imaging-
resection of cT3-4 rectal cancer after preoperative radiotherapy or detected tumor response for locally advanced rectal cancer predicts
radiochemotherapy: does anybody benefit from adjuvant fluorouracil- survival outcomes: MERCURY experience. J Clin Oncol 2011;29:3753-
based chemotherapy? A trial of the European Organisation for Research 3760. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21876084.
and Treatment of Cancer Radiation Oncology Group. J Clin Oncol
2007;25:4379-4386. Available at: 401. Fokas E, Liersch T, Fietkau R, et al. Tumor regression grading after
http://www.ncbi.nlm.nih.gov/pubmed/17906203. preoperative chemoradiotherapy for locally advanced rectal carcinoma
revisited: updated results of the CAO/ARO/AIO-94 trial. J Clin Oncol
394. Das P, Skibber JM, Rodriguez-Bigas MA, et al. Clinical and 2014;32:1554-1562. Available at:
pathologic predictors of locoregional recurrence, distant metastasis, and http://www.ncbi.nlm.nih.gov/pubmed/24752056.
overall survival in patients treated with chemoradiation and mesorectal
excision for rectal cancer. Am J Clin Oncol 2006;29:219-224. Available at: 402. Fokas E, Strobel P, Fietkau R, et al. Tumor regression grading after
http://www.ncbi.nlm.nih.gov/pubmed/16755173. preoperative chemoradiotherapy as a prognostic factor and individual-level
surrogate for disease-free survival in rectal cancer. J Natl Cancer Inst
395. Das P, Skibber JM, Rodriguez-Bigas MA, et al. Predictors of tumor 2017;109. Available at: https://www.ncbi.nlm.nih.gov/pubmed/29206996.
response and downstaging in patients who receive preoperative
chemoradiation for rectal cancer. Cancer 2007;109:1750-1755. Available 403. Karagkounis G, Thai L, Mace AG, et al. Prognostic implications of
at: http://www.ncbi.nlm.nih.gov/pubmed/17387743. pathological response to neoadjuvant chemoradiation in pathologic stage
III rectal cancer. Ann Surg 2019;269:1117-1123. Available at:
396. Fietkau R, Barten M, Klautke G, et al. Postoperative chemotherapy https://www.ncbi.nlm.nih.gov/pubmed/29465458.
may not be necessary for patients with ypN0-category after neoadjuvant
chemoradiotherapy of rectal cancer. Dis Colon Rectum 2006;49:1284- 404. Janjan NA, Crane C, Feig BW, et al. Improved overall survival among
1292. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16758130. responders to preoperative chemoradiation for locally advanced rectal
cancer. Am J Clin Oncol 2001;24:107-112. Available at:
397. Park IJ, You YN, Agarwal A, et al. Neoadjuvant treatment response http://www.ncbi.nlm.nih.gov/pubmed/11319280.
as an early response indicator for patients with rectal cancer. J Clin Oncol
2012;30:1770-1776. Available at: 405. Habr-Gama A, Perez RO, Nadalin W, et al. Operative versus
http://www.ncbi.nlm.nih.gov/pubmed/22493423. nonoperative treatment for stage 0 distal rectal cancer following
chemoradiation therapy: long-term results. Ann Surg 2004;240:711-717;
398. Silberfein EJ, Kattepogu KM, Hu CY, et al. Long-term survival and discussion 717-718. Available at:
recurrence outcomes following surgery for distal rectal cancer. Ann Surg http://www.ncbi.nlm.nih.gov/pubmed/15383798.
Oncol 2010;17:2863-2869. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/20552409. 406. Glynne-Jones R, Wallace M, Livingstone JI, Meyrick-Thomas J.
Complete clinical response after preoperative chemoradiation in rectal
399. Smith KD, Tan D, Das P, et al. Clinical significance of acellular mucin cancer: is a "wait and see" policy justified? Dis Colon Rectum 2008;51:10-
in rectal adenocarcinoma patients with a pathologic complete response to

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Rectal Cancer

19; discussion 19-20. Available at: Surg Oncol 2017;24:1904-1915. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/18043968. https://www.ncbi.nlm.nih.gov/pubmed/28324284.

407. Maas M, Beets-Tan RG, Lambregts DM, et al. Wait-and-see policy 414. Kong JC, Guerra GR, Warrier SK, et al. Outcome and salvage
for clinical complete responders after chemoradiation for rectal cancer. J surgery following "watch and wait" for rectal cancer after neoadjuvant
Clin Oncol 2011;29:4633-4640. Available at: therapy: A systematic review. Dis Colon Rectum 2017;60:335-345.
http://www.ncbi.nlm.nih.gov/pubmed/22067400. Available at: https://www.ncbi.nlm.nih.gov/pubmed/28177997.

408. Appelt AL, Ploen J, Harling H, et al. High-dose chemoradiotherapy 415. van der Valk MJM, Hilling DE, Bastiaannet E, et al. Long-term
and watchful waiting for distal rectal cancer: a prospective observational outcomes of clinical complete responders after neoadjuvant treatment for
study. Lancet Oncol 2015;16:919-927. Available at: rectal cancer in the International Watch & Wait Database (IWWD): an
http://www.ncbi.nlm.nih.gov/pubmed/26156652. international multicentre registry study. Lancet 2018;391:2537-2545.
Available at: https://www.ncbi.nlm.nih.gov/pubmed/29976470.
409. Habr-Gama A, Gama-Rodrigues J, Sao Juliao GP, et al. Local
recurrence after complete clinical response and watch and wait in rectal 416. Fernandez LM, Sao Juliao GP, Figueiredo NL, et al. Conditional
cancer after neoadjuvant chemoradiation: impact of salvage therapy on recurrence-free survival of clinical complete responders managed by
local disease control. Int J Radiat Oncol Biol Phys 2014;88:822-828. watch and wait after neoadjuvant chemoradiotherapy for rectal cancer in
Available at: http://www.ncbi.nlm.nih.gov/pubmed/24495589. the International Watch & Wait Database: a retrospective, international,
multicentre registry study. Lancet Oncol 2021;22:43-50. Available at:
410. Li J, Liu H, Yin J, et al. Wait-and-see or radical surgery for rectal https://www.ncbi.nlm.nih.gov/pubmed/33316218.
cancer patients with a clinical complete response after neoadjuvant
chemoradiotherapy: a cohort study. Oncotarget 2015;6:42354-42361. 417. Glynne-Jones R, Hughes R. Critical appraisal of the 'wait and see'
Available at: http://www.ncbi.nlm.nih.gov/pubmed/26472284. approach in rectal cancer for clinical complete responders after
chemoradiation. Br J Surg 2012;99:897-909. Available at:
411. Smith JJ, Strombom P, Chow OS, et al. Assessment of a Watch-and- http://www.ncbi.nlm.nih.gov/pubmed/22539154.
Wait Strategy for Rectal Cancer in Patients With a Complete Response
After Neoadjuvant Therapy. JAMA Oncol 2019;5:e185896. Available at: 418. Nahas SC, Rizkallah Nahas CS, Sparapan Marques CF, et al.
https://www.ncbi.nlm.nih.gov/pubmed/30629084. Pathologic complete response in rectal cancer: can we detect it? Lessons
learned from a proposed randomized trial of watch-and-wait treatment of
412. Dossa F, Chesney TR, Acuna SA, Baxter NN. A watch-and-wait rectal cancer. Dis Colon Rectum 2016;59:255-263. Available at:
approach for locally advanced rectal cancer after a clinical complete https://www.ncbi.nlm.nih.gov/pubmed/26953983.
response following neoadjuvant chemoradiation: a systematic review and
meta-analysis. Lancet Gastroenterol Hepatol 2017;2:501-513. Available 419. Tranchart H, Lefevre JH, Svrcek M, et al. What is the incidence of
at: https://www.ncbi.nlm.nih.gov/pubmed/28479372. metastatic lymph node involvement after significant pathologic response of
primary tumor following neoadjuvant treatment for locally advanced rectal
413. Sammour T, Price BA, Krause KJ, Chang GJ. Nonoperative cancer? Ann Surg Oncol 2013;20:1551-1559. Available at:
management or 'watch and wait' for rectal cancer with complete clinical http://www.ncbi.nlm.nih.gov/pubmed/23188545.
response after neoadjuvant chemoradiotherapy: A critical appraisal. Ann

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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Rectal Cancer

420. Renehan AG, Malcomson L, Emsley R, et al. Watch-and-wait randomized phase III trial. Ann Oncol 2015;26:696-701. Available at:
approach versus surgical resection after chemoradiotherapy for patients http://www.ncbi.nlm.nih.gov/pubmed/25480874.
with rectal cancer (the OnCoRe project): a propensity-score matched
cohort analysis. Lancet Oncol 2016;17:174-183. Available at: 427. Benson AB, Catalan P, Meropol NJ, et al. ECOG E3201: Intergroup
http://www.ncbi.nlm.nih.gov/pubmed/26705854. randomized phase III study of postoperative irinotecan, 5- fluorouracil
(FU), leucovorin (LV) (FOLFIRI) vs oxaliplatin, FU/LV (FOLFOX) vs FU/LV
421. Ellis CT, Samuel CA, Stitzenberg KB. National trends in nonoperative for patients (pts) with stage II/ III rectal cancer receiving either pre or
management of rectal adenocarcinoma. J Clin Oncol 2016;34:1644-1651. postoperative radiation (RT)/ FU [abstract]. J Clin Oncol 2006;24 (June 20
Available at: https://www.ncbi.nlm.nih.gov/pubmed/27022115. suppl):3526. Available at:
http://ascopubs.org/doi/abs/10.1200/jco.2006.24.18_suppl.3526.
422. Bujko K, Glimelius B, Valentini V, et al. Postoperative chemotherapy
in patients with rectal cancer receiving preoperative radio(chemo)therapy: 428. Hong YS, Nam BH, Kim KP, et al. Oxaliplatin, fluorouracil, and
A meta-analysis of randomized trials comparing surgery +/- a leucovorin versus fluorouracil and leucovorin as adjuvant chemotherapy
fluoropyrimidine and surgery + a fluoropyrimidine +/- oxaliplatin. Eur J for locally advanced rectal cancer after preoperative chemoradiotherapy
Surg Oncol 2015;41:713-723. Available at: (ADORE): an open-label, multicentre, phase 2, randomised controlled trial.
https://www.ncbi.nlm.nih.gov/pubmed/25911110. Lancet Oncol 2014;15:1245-1253. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/25201358.
423. Wolmark N, Wieand HS, Hyams DM, et al. Randomized trial of
postoperative adjuvant chemotherapy with or without radiotherapy for 429. Hong YS, Kim SY, Lee JS, et al. Oxaliplatin-Based Adjuvant
carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Chemotherapy for Rectal Cancer After Preoperative Chemoradiotherapy
Project Protocol R-02. J Natl Cancer Inst 2000;92:388-396. Available at: (ADORE): Long-Term Results of a Randomized Controlled Trial. J Clin
http://www.ncbi.nlm.nih.gov/pubmed/10699069. Oncol 2019;37:3111-3123. Available at:
https://pubmed.ncbi.nlm.nih.gov/31593484/.
424. Bosset JF, Calais G, Mineur L, et al. Fluorouracil-based adjuvant
chemotherapy after preoperative chemoradiotherapy in rectal cancer: 430. Garcia-Albeniz X, Gallego R, Hofheinz RD, et al. Adjuvant therapy
long-term results of the EORTC 22921 randomised study. Lancet Oncol sparing in rectal cancer achieving complete response after
2014;15:184-190. Available at: chemoradiation. World J Gastroenterol 2014;20:15820-15829. Available
http://www.ncbi.nlm.nih.gov/pubmed/24440473. at: http://www.ncbi.nlm.nih.gov/pubmed/25400468.

425. Sainato A, Cernusco Luna Nunzia V, Valentini V, et al. No benefit of 431. Breugom AJ, Swets M, Bosset JF, et al. Adjuvant chemotherapy after
adjuvant fluorouracil leucovorin chemotherapy after neoadjuvant preoperative (chemo)radiotherapy and surgery for patients with rectal
chemoradiotherapy in locally advanced cancer of the rectum (LARC): long cancer: a systematic review and meta-analysis of individual patient data.
term results of a randomized trial (I-CNR-RT). Radiother Oncol Lancet Oncol 2015;16:200-207. Available at:
2014;113:223-229. Available at: http://www.ncbi.nlm.nih.gov/pubmed/25589192.
http://www.ncbi.nlm.nih.gov/pubmed/25454175.
432. Petersen SH, Harling H, Kirkeby LT, et al. Postoperative adjuvant
426. Breugom AJ, van Gijn W, Muller EW, et al. Adjuvant chemotherapy chemotherapy in rectal cancer operated for cure. Cochrane Database Syst
for rectal cancer patients treated with preoperative (chemo)radiotherapy Rev 2012;3:CD004078. Available at:
and total mesorectal excision: a Dutch Colorectal Cancer Group (DCCG) http://www.ncbi.nlm.nih.gov/pubmed/22419291.

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NCCN Guidelines Version 4.2024

Rectal Cancer

433. Petrelli F, Coinu A, Lonati V, Barni S. A systematic review and meta- 440. Margalit O, Mamtani R, Kopetz S, et al. Refining the Use of Adjuvant
analysis of adjuvant chemotherapy after neoadjuvant treatment and Oxaliplatin in Clinical Stage II or III Rectal Adenocarcinoma. Oncologist
surgery for rectal cancer. Int J Colorectal Dis 2015;30:447-457. Available 2019;24:e671-e676. Available at:
at: http://www.ncbi.nlm.nih.gov/pubmed/25433820. https://www.ncbi.nlm.nih.gov/pubmed/30696723.

434. Carvalho C, Glynne-Jones R. Challenges behind proving efficacy of 441. Chakravarthy AB, Zhao F, Meropol NJ, et al. Intergroup Randomized
adjuvant chemotherapy after preoperative chemoradiation for rectal Phase III Study of Postoperative Oxaliplatin, 5-Fluorouracil, and
cancer. Lancet Oncol 2017;18:e354-e363. Available at: Leucovorin Versus Oxaliplatin, 5-Fluorouracil, Leucovorin, and
https://www.ncbi.nlm.nih.gov/pubmed/28593861. Bevacizumab for Patients with Stage II or III Rectal Cancer Receiving
Preoperative Chemoradiation: A Trial of the ECOG-ACRIN Research
435. Loree JM, Kennecke HF, Lee-Ying RM, et al. Impact of postoperative Group (E5204). Oncologist 2020;25:e798-e807. Available at:
adjuvant chemotherapy following long-course chemoradiotherapy in stage https://pubmed.ncbi.nlm.nih.gov/31852811/.
II rectal cancer. Am J Clin Oncol 2018;41:643-648. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/27819876. 442. Biagi JJ, Raphael MJ, Mackillop WJ, et al. Association between time
to initiation of adjuvant chemotherapy and survival in colorectal cancer: a
436. Hu X, Li YQ, Li QG, et al. Adjuvant chemotherapy seemed not to systematic review and meta-analysis. JAMA 2011;305:2335-2342.
have survival benefit in rectal cancer patients with ypTis-2N0 after Available at: http://www.ncbi.nlm.nih.gov/pubmed/21642686.
preoperative radiotherapy and surgery from a population-based propensity
score analysis. Oncologist 2019;24:803-811. Available at: 443. Des Guetz G, Nicolas P, Perret GY, et al. Does delaying adjuvant
https://www.ncbi.nlm.nih.gov/pubmed/29674444. chemotherapy after curative surgery for colorectal cancer impair survival?
A meta-analysis. Eur J Cancer 2010;46:1049-1055. Available at:
437. Garlipp B, Ptok H, Benedix F, et al. Adjuvant treatment for resected http://www.ncbi.nlm.nih.gov/pubmed/20138505.
rectal cancer: impact of standard and intensified postoperative
chemotherapy on disease-free survival in patients undergoing 444. Fakih M. Treating rectal cancer: key issues reconsidered. Oncology
preoperative chemoradiation-a propensity score-matched analysis of an (Williston Park) 2008;22:1444-1446. Available at:
observational database. Langenbecks Arch Surg 2016;401:1179-1190. http://www.ncbi.nlm.nih.gov/pubmed/19322952.
Available at: https://www.ncbi.nlm.nih.gov/pubmed/27830368.
445. Minsky BD, Guillem JG. Multidisciplinary management of resectable
438. Polanco PM, Mokdad AA, Zhu H. Association of adjuvant rectal cancer. New developments and controversies. Oncology (Williston
chemotherapy with overall survival in patients with rectal cancer and Park) 2008;22:1430-1437. Available at:
pathologic complete response following neoadjuvant chemotherapy and http://www.ncbi.nlm.nih.gov/pubmed/19086601.
resection. JAMA Oncol 2018;4:938-943. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/29710272. 446. Andre T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil,
and leucovorin as adjuvant treatment for colon cancer. N Engl J Med
439. Shahab D, Gabriel E, Attwood K, et al. Adjuvant chemotherapy is 2004;350:2343-2351. Available at:
associated with improved overall survival in locally advanced rectal cancer http://www.ncbi.nlm.nih.gov/pubmed/15175436.
after achievement of a pathologic complete response to chemoradiation.
Clin Colorectal Cancer 2017;16:300-307. Available at: 447. Borstlap WA, Coeymans TJ, Tanis PJ, et al. Meta-analysis of
https://www.ncbi.nlm.nih.gov/pubmed/28420585. oncological outcomes after local excision of pT1-2 rectal cancer requiring

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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adjuvant (chemo)radiotherapy or completion surgery. Br J Surg 455. Willett CG, Czito BG, Tyler DS. Intraoperative radiation therapy. J
2016;103:1105-1116. Available at: Clin Oncol 2007;25:971-977. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/27302385. http://www.ncbi.nlm.nih.gov/pubmed/17350946.

448. Garcia-Aguilar J, Mellgren A, Sirivongs P, et al. Local excision of 456. Lee WS, Yun SH, Chun HK, et al. Pulmonary resection for
rectal cancer without adjuvant therapy: a word of caution. Ann Surg metastases from colorectal cancer: prognostic factors and survival. Int J
2000;231:345-351. Available at: Colorectal Dis 2007;22:699-704. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/10714627. http://www.ncbi.nlm.nih.gov/pubmed/17109105.

449. Sengupta S, Tjandra JJ. Local excision of rectal cancer: what is the 457. Van Cutsem E, Nordlinger B, Adam R, et al. Towards a pan-
evidence? Dis Colon Rectum 2001;44:1345-1361. Available at: European consensus on the treatment of patients with colorectal liver
http://www.ncbi.nlm.nih.gov/pubmed/11584215. metastases. Eur J Cancer 2006;42:2212-2221. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/16904315.
450. Willett CG, Badizadegan K, Ancukiewicz M, Shellito PC. Prognostic
factors in stage T3N0 rectal cancer: do all patients require postoperative 458. Yoo PS, Lopez-Soler RI, Longo WE, Cha CH. Liver resection for
pelvic irradiation and chemotherapy? Dis Colon Rectum 1999;42:167-173. metastatic colorectal cancer in the age of neoadjuvant chemotherapy and
Available at: https://www.ncbi.nlm.nih.gov/pubmed/10211491. bevacizumab. Clin Colorectal Cancer 2006;6:202-207. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/17026789.
451. Alberda WJ, Verhoef C, Nuyttens JJ, et al. Intraoperative radiation
therapy reduces local recurrence rates in patients with microscopically 459. Alberts SR, Horvath WL, Sternfeld WC, et al. Oxaliplatin, fluorouracil,
involved circumferential resection margins after resection of locally and leucovorin for patients with unresectable liver-only metastases from
advanced rectal cancer. Int J Radiat Oncol Biol Phys 2014;88:1032-1040. colorectal cancer: a North Central Cancer Treatment Group phase II
Available at: http://www.ncbi.nlm.nih.gov/pubmed/24661656. study. J Clin Oncol 2005;23:9243-9249. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/16230673.
452. Hahnloser D, Haddock MG, Nelson H. Intraoperative radiotherapy in
the multimodality approach to colorectal cancer. Surg Oncol Clin N Am 460. Dawood O, Mahadevan A, Goodman KA. Stereotactic body radiation
2003;12:993-1013, ix. Available at: therapy for liver metastases. Eur J Cancer 2009;45:2947-2959. Available
http://www.ncbi.nlm.nih.gov/pubmed/14989129. at: http://www.ncbi.nlm.nih.gov/pubmed/19773153.

453. Hyngstrom JR, Tzeng CW, Beddar S, et al. Intraoperative radiation 461. Kemeny N. Management of liver metastases from colorectal cancer.
therapy for locally advanced primary and recurrent colorectal cancer: ten- Oncology (Williston Park) 2006;20:1161-1176, 1179; discussion 1179-
year institutional experience. J Surg Oncol 2014;109:652-658. Available 1180, 1185-1166. Available at:
at: http://www.ncbi.nlm.nih.gov/pubmed/24510523. http://www.ncbi.nlm.nih.gov/pubmed/17024869.

454. Valentini V, Balducci M, Tortoreto F, et al. Intraoperative 462. Fong Y, Cohen AM, Fortner JG, et al. Liver resection for colorectal
radiotherapy: current thinking. Eur J Surg Oncol 2002;28:180-185. metastases. J Clin Oncol 1997;15:938-946. Available at:
Available at: http://www.ncbi.nlm.nih.gov/pubmed/11884054. http://www.ncbi.nlm.nih.gov/pubmed/9060531.

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463. Tsai M-S, Su Y-H, Ho M-C, et al. Clinicopathological features and 471. Van Cutsem E, Cervantes A, Adam R, et al. ESMO consensus
prognosis in resectable synchronous and metachronous colorectal liver guidelines for the management of patients with metastatic colorectal
metastasis. Ann Surg Oncol 2007;14:786-794. Available at: cancer. Ann Oncol 2016;27:1386-1422. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/17103254. https://www.ncbi.nlm.nih.gov/pubmed/27380959.

464. Foster JH. Treatment of metastatic disease of the liver: a skeptic's 472. Venook AP. The Kemeny article reviewed: management of liver
view. Semin Liver Dis 1984;4:170-179. Available at: metastases from colorectal cancer: review 2. Oncology 2006;20. Available
http://www.ncbi.nlm.nih.gov/pubmed/6205450. at: http://www.cancernetwork.com/display/article/10165/108033.

465. Stangl R, Altendorf-Hofmann A, Charnley RM, Scheele J. Factors 473. Kanas GP, Taylor A, Primrose JN, et al. Survival after liver resection
influencing the natural history of colorectal liver metastases. Lancet in metastatic colorectal cancer: review and meta-analysis of prognostic
1994;343:1405-1410. Available at: factors. Clin Epidemiol 2012;4:283-301. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/7515134. http://www.ncbi.nlm.nih.gov/pubmed/23152705.

466. Adam R, Delvart V, Pascal G, et al. Rescue surgery for unresectable 474. Aloia TA, Vauthey JN, Loyer EM, et al. Solitary colorectal liver
colorectal liver metastases downstaged by chemotherapy: a model to metastasis: resection determines outcome. Arch Surg 2006;141:460-466;
predict long-term survival. Ann Surg 2004;240:644-657; discussion 657- discussion 466-467. Available at:
648. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15383792. http://www.ncbi.nlm.nih.gov/pubmed/16702517.

467. Choti MA, Sitzmann JV, Tiburi MF, et al. Trends in long-term survival 475. Hur H, Ko YT, Min BS, et al. Comparative study of resection and
following liver resection for hepatic colorectal metastases. Ann Surg radiofrequency ablation in the treatment of solitary colorectal liver
2002;235:759-766. Available at: metastases. Am J Surg 2009;197:728-736. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/12035031. http://www.ncbi.nlm.nih.gov/pubmed/18789428.

468. Elias D, Liberale G, Vernerey D, et al. Hepatic and extrahepatic 476. Lee WS, Yun SH, Chun HK, et al. Clinical outcomes of hepatic
colorectal metastases: when resectable, their localization does not matter, resection and radiofrequency ablation in patients with solitary colorectal
but their total number has a prognostic effect. Ann Surg Oncol liver metastasis. J Clin Gastroenterol 2008;42:945-949. Available at:
2005;12:900-909. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18438208.
http://www.ncbi.nlm.nih.gov/pubmed/16184442.
477. Charnsangavej C, Clary B, Fong Y, et al. Selection of patients for
469. Fong Y, Salo J. Surgical therapy of hepatic colorectal metastasis. resection of hepatic colorectal metastases: expert consensus statement.
Semin Oncol 1999;26:514-523. Available at: Ann Surg Oncol 2006;13:1261-1268. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/10528899. http://www.ncbi.nlm.nih.gov/pubmed/16947009.

470. Pawlik TM, Scoggins CR, Zorzi D, et al. Effect of surgical margin 478. Gonzalez M, Poncet A, Combescure C, et al. Risk factors for survival
status on survival and site of recurrence after hepatic resection for after lung metastasectomy in colorectal cancer patients: a systematic
colorectal metastases. Ann Surg 2005;241:715-722, discussion 722-714. review and meta-analysis. Ann Surg Oncol 2013;20:572-579. Available at:
Available at: http://www.ncbi.nlm.nih.gov/pubmed/15849507. http://www.ncbi.nlm.nih.gov/pubmed/23104709.

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Rectal Cancer

479. Gonzalez M, Gervaz P. Risk factors for survival after lung metastases. PLoS One 2017;12:e0173933. Available at:
metastasectomy in colorectal cancer patients: systematic review and https://www.ncbi.nlm.nih.gov/pubmed/28328956.
meta-analysis. Future Oncol 2015;11:31-33. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/25662325. 487. Carpizo DR, Are C, Jarnagin W, et al. Liver resection for metastatic
colorectal cancer in patients with concurrent extrahepatic disease: results
480. Onaitis MW, Petersen RP, Haney JC, et al. Prognostic factors for in 127 patients treated at a single center. Ann Surg Oncol 2009;16:2138-
recurrence after pulmonary resection of colorectal cancer metastases. Ann 2146. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19495884.
Thorac Surg 2009;87:1684-1688. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/19463577. 488. Carpizo DR, D'Angelica M. Liver resection for metastatic colorectal
cancer in the presence of extrahepatic disease. Ann Surg Oncol
481. Brouquet A, Vauthey JN, Contreras CM, et al. Improved survival after 2009;16:2411-2421. Available at:
resection of liver and lung colorectal metastases compared with liver-only http://www.ncbi.nlm.nih.gov/pubmed/19554376.
metastases: a study of 112 patients with limited lung metastatic disease. J
Am Coll Surg 2011;213:62-69. Available at: 489. Chua TC, Saxena A, Liauw W, et al. Hepatectomy and resection of
http://www.ncbi.nlm.nih.gov/pubmed/21700179. concomitant extrahepatic disease for colorectal liver metastases--a
systematic review. Eur J Cancer 2012;48:1757-1765. Available at:
482. Hadden WJ, de Reuver PR, Brown K, et al. Resection of colorectal http://www.ncbi.nlm.nih.gov/pubmed/22153217.
liver metastases and extra-hepatic disease: a systematic review and
proportional meta-analysis of survival outcomes. HPB (Oxford) 490. Wurster EF, Tenckhoff S, Probst P, et al. A systematic review and
2016;18:209-220. Available at: meta-analysis of the utility of repeated versus single hepatic resection for
https://www.ncbi.nlm.nih.gov/pubmed/27017160. colorectal cancer liver metastases. HPB (Oxford) 2017;19:491-497.
Available at: https://www.ncbi.nlm.nih.gov/pubmed/28347640.
483. Headrick JR, Miller DL, Nagorney DM, et al. Surgical treatment of
hepatic and pulmonary metastases from colon cancer. Ann Thorac Surg 491. Andreou A, Brouquet A, Abdalla EK, et al. Repeat hepatectomy for
2001;71:975-979; discussion 979-980. Available at: recurrent colorectal liver metastases is associated with a high survival
http://www.ncbi.nlm.nih.gov/pubmed/11269484. rate. HPB (Oxford) 2011;13:774-782. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/21999590.
484. Marin C, Robles R, Lopez Conesa A, et al. Outcome of strict patient
selection for surgical treatment of hepatic and pulmonary metastases from 492. de Jong MC, Mayo SC, Pulitano C, et al. Repeat curative intent liver
colorectal cancer. Dis Colon Rectum 2013;56:43-50. Available at: surgery is safe and effective for recurrent colorectal liver metastasis:
http://www.ncbi.nlm.nih.gov/pubmed/23222279. results from an international multi-institutional analysis. J Gastrointest
Surg 2009;13:2141-2151. Available at:
485. Pulitano C, Bodingbauer M, Aldrighetti L, et al. Liver resection for http://www.ncbi.nlm.nih.gov/pubmed/19795176.
colorectal metastases in presence of extrahepatic disease: results from an
international multi-institutional analysis. Ann Surg Oncol 2011;18:1380- 493. Homayounfar K, Bleckmann A, Conradi LC, et al. Metastatic
1388. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21136180. recurrence after complete resection of colorectal liver metastases: impact
of surgery and chemotherapy on survival. Int J Colorectal Dis
486. Wiegering A, Riegel J, Wagner J, et al. The impact of pulmonary 2013;28:1009-1017. Available at:
metastasectomy in patients with previously resected colorectal cancer liver http://www.ncbi.nlm.nih.gov/pubmed/23371333.

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Rectal Cancer

494. Neeff HP, Drognitz O, Holzner P, et al. Outcome after repeat 2012;265:958-968. Available at:
resection of liver metastases from colorectal cancer. Int J Colorectal Dis http://www.ncbi.nlm.nih.gov/pubmed/23091175.
2013;28:1135-1141. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/23468250. 502. Ruers T, Van Coevorden F, Punt CJ, et al. Local Treatment of
Unresectable Colorectal Liver Metastases: Results of a Randomized
495. Luo LX, Yu ZY, Huang JW, Wu H. Selecting patients for a second Phase II Trial. J Natl Cancer Inst 2017;109. Available at:
hepatectomy for colorectal metastases: An systemic review and meta- https://www.ncbi.nlm.nih.gov/pubmed/28376151.
analysis. Eur J Surg Oncol 2014;40:1036-1048. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24915859. 503. Lee MT, Kim JJ, Dinniwell R, et al. Phase I study of individualized
stereotactic body radiotherapy of liver metastases. J Clin Oncol
496. Adam R, Bismuth H, Castaing D, et al. Repeat hepatectomy for 2009;27:1585-1591. Available at:
colorectal liver metastases. Ann Surg 1997;225:51-60; discussion 60-52. http://www.ncbi.nlm.nih.gov/pubmed/19255313.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/8998120.
504. Rusthoven KE, Kavanagh BD, Cardenes H, et al. Multi-institutional
497. Salah S, Watanabe K, Park JS, et al. Repeated resection of phase I/II trial of stereotactic body radiation therapy for liver metastases. J
colorectal cancer pulmonary oligometastases: pooled analysis and Clin Oncol 2009;27:1572-1578. Available at:
prognostic assessment. Ann Surg Oncol 2013;20:1955-1961. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19255321.
http://www.ncbi.nlm.nih.gov/pubmed/23334254.
505. Alsina J, Choti MA. Liver-directed therapies in colorectal cancer.
498. Poultsides GA, Servais EL, Saltz LB, et al. Outcome of primary tumor Semin Oncol 2011;38:561-567. Available at:
in patients with synchronous stage IV colorectal cancer receiving http://www.ncbi.nlm.nih.gov/pubmed/21810515.
combination chemotherapy without surgery as initial treatment. J Clin
Oncol 2009;27:3379-3384. Available at: 506. Johnston FM, Mavros MN, Herman JM, Pawlik TM. Local therapies
http://www.ncbi.nlm.nih.gov/pubmed/19487380. for hepatic metastases. J Natl Compr Canc Netw 2013;11:153-160.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/23411382.
499. Gillams A, Goldberg N, Ahmed M, et al. Thermal ablation of
colorectal liver metastases: a position paper by an international panel of 507. Park J, Chen YJ, Lu WP, Fong Y. The evolution of liver-directed
ablation experts, the interventional oncology sans frontieres meeting 2013. treatments for hepatic colorectal metastases. Oncology (Williston Park)
Eur Radiol 2015;25:3438-3454. Available at: 2014;28:991-1003. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/25994193. http://www.ncbi.nlm.nih.gov/pubmed/25403632.

500. Shady W, Petre EN, Gonen M, et al. Percutaneous radiofrequency 508. Zacharias AJ, Jayakrishnan TT, Rajeev R, et al. Comparative
ablation of colorectal cancer liver metastases: factors affecting outcomes- effectiveness of hepatic artery based therapies for unresectable colorectal
a 10-year experience at a single center. Radiology 2016;278:601-611. liver metastases: a meta-analysis. PLoS One 2015;10:e0139940.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/26267832. Available at: http://www.ncbi.nlm.nih.gov/pubmed/26448327.

501. Solbiati L, Ahmed M, Cova L, et al. Small liver colorectal metastases 509. Kemeny N, Huang Y, Cohen AM, et al. Hepatic arterial infusion of
treated with percutaneous radiofrequency ablation: local response rate chemotherapy after resection of hepatic metastases from colorectal
and long-term survival with up to 10-year follow-up. Radiology

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cancer. N Engl J Med 1999;341:2039-2048. Available at: liver metastases: systematic review. J Vasc Interv Radiol 2013;24:1209-
http://www.ncbi.nlm.nih.gov/pubmed/10615075. 1217. Available at: http://www.ncbi.nlm.nih.gov/pubmed/23885916.

510. Kemeny NE, Gonen M. Hepatic arterial infusion after liver resection. 517. Martin RC, 2nd, Scoggins CR, Schreeder M, et al. Randomized
N Engl J Med 2005;352:734-735. Available at: controlled trial of irinotecan drug-eluting beads with simultaneous FOLFOX
http://www.ncbi.nlm.nih.gov/pubmed/15716576. and bevacizumab for patients with unresectable colorectal liver-limited
metastasis. Cancer 2015;121:3649-3658. Available at:
511. Ghiringhelli F, Vincent J, Bengrine L, et al. Hepatic arterial http://www.ncbi.nlm.nih.gov/pubmed/26149602.
chemotherapy with raltitrexed and oxaliplatin versus standard
chemotherapy in unresectable liver metastases from colorectal cancer 518. Lammer J, Malagari K, Vogl T, et al. Prospective randomized study of
after conventional chemotherapy failure (HEARTO): a randomized phase- doxorubicin-eluting-bead embolization in the treatment of hepatocellular
II study. J Cancer Res Clin Oncol 2019;145:2357-2363. Available at: carcinoma: results of the PRECISION V study. Cardiovasc Intervent
https://www.ncbi.nlm.nih.gov/pubmed/31273511. Radiol 2010;33:41-52. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/19908093.
512. Chan DL, Alzahrani NA, Morris DL, Chua TC. Systematic review and
meta-analysis of hepatic arterial infusion chemotherapy as bridging 519. Martin RC, Howard J, Tomalty D, et al. Toxicity of irinotecan-eluting
therapy for colorectal liver metastases. Surg Oncol 2015;24:162-171. beads in the treatment of hepatic malignancies: results of a multi-
Available at: https://www.ncbi.nlm.nih.gov/pubmed/26133575. institutional registry. Cardiovasc Intervent Radiol 2010;33:960-966.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/20661569.
513. Levi FA, Boige V, Hebbar M, et al. Conversion to resection of liver
metastases from colorectal cancer with hepatic artery infusion of 520. Pawlik TM, Reyes DK, Cosgrove D, et al. Phase II trial of sorafenib
combined chemotherapy and systemic cetuximab in multicenter trial combined with concurrent transarterial chemoembolization with drug-
OPTILIV. Ann Oncol 2016;27:267-274. Available at: eluting beads for hepatocellular carcinoma. J Clin Oncol 2011;29:3960-
https://www.ncbi.nlm.nih.gov/pubmed/26578731. 3967. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21911714.

514. Pak LM, Kemeny NE, Capanu M, et al. Prospective phase II trial of 521. Reyes DK, Vossen JA, Kamel IR, et al. Single-center phase II trial of
combination hepatic artery infusion and systemic chemotherapy for transarterial chemoembolization with drug-eluting beads for patients with
unresectable colorectal liver metastases: Long term results and curative unresectable hepatocellular carcinoma: initial experience in the United
potential. J Surg Oncol 2018;117:634-643. Available at: States. Cancer J 2009;15:526-532. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/29165816. http://www.ncbi.nlm.nih.gov/pubmed/20010173.

515. Fiorentini G, Aliberti C, Tilli M, et al. Intra-arterial infusion of 522. van Malenstein H, Maleux G, Vandecaveye V, et al. A randomized
irinotecan-loaded drug-eluting beads (DEBIRI) versus intravenous therapy phase II study of drug-eluting beads versus transarterial
(FOLFIRI) for hepatic metastases from colorectal cancer: final results of a chemoembolization for unresectable hepatocellular carcinoma. Onkologie
phase III study. Anticancer Res 2012;32:1387-1395. Available at: 2011;34:368-376. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/22493375. http://www.ncbi.nlm.nih.gov/pubmed/21734423.

516. Richardson AJ, Laurence JM, Lam VW. Transarterial 523. Vogl TJ, Lammer J, Lencioni R, et al. Liver, gastrointestinal, and
chemoembolization with irinotecan beads in the treatment of colorectal cardiac toxicity in intermediate hepatocellular carcinoma treated with

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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PRECISION TACE with drug-eluting beads: results from the PRECISION 530. Kennedy AS, Ball D, Cohen SJ, et al. Multicenter evaluation of the
V randomized trial. AJR Am J Roentgenol 2011;197:W562-570. Available safety and efficacy of radioembolization in patients with unresectable
at: http://www.ncbi.nlm.nih.gov/pubmed/21940527. colorectal liver metastases selected as candidates for (90)Y resin
microspheres. J Gastrointest Oncol 2015;6:134-142. Available at:
524. Riemsma RP, Bala MM, Wolff R, Kleijnen J. Transarterial http://www.ncbi.nlm.nih.gov/pubmed/25830033.
(chemo)embolisation versus no intervention or placebo intervention for
liver metastases. Cochrane Database Syst Rev 2013;4:CD009498. 531. Saxena A, Meteling B, Kapoor J, et al. Is yttrium-90 radioembolization
Available at: http://www.ncbi.nlm.nih.gov/pubmed/23633373. a viable treatment option for unresectable, chemorefractory colorectal
cancer liver metastases? A large single-center experience of 302 patients.
525. Hendlisz A, Van den Eynde M, Peeters M, et al. Phase III trial Ann Surg Oncol 2015;22:794-802. Available at:
comparing protracted intravenous fluorouracil infusion alone or with http://www.ncbi.nlm.nih.gov/pubmed/25323474.
yttrium-90 resin microspheres radioembolization for liver-limited metastatic
colorectal cancer refractory to standard chemotherapy. J Clin Oncol 532. Mulcahy MF, Mahvash A, Pracht M, et al. Radioembolization With
2010;28:3687-3694. Available at: Chemotherapy for Colorectal Liver Metastases: A Randomized, Open-
http://www.ncbi.nlm.nih.gov/pubmed/20567019. Label, International, Multicenter, Phase III Trial. J Clin Oncol
2021;39:3897-3907. Available at:
526. Benson AB, 3rd, Geschwind JF, Mulcahy MF, et al. https://www.ncbi.nlm.nih.gov/pubmed/34541864.
Radioembolisation for liver metastases: results from a prospective 151
patient multi-institutional phase II study. Eur J Cancer 2013;49:3122-3130. 533. van Hazel GA, Heinemann V, Sharma NK, et al. SIRFLOX:
Available at: http://www.ncbi.nlm.nih.gov/pubmed/23777743. randomized phase III trial comparing first-line mFOLFOX6 (plus or minus
bevacizumab) versus mFOLFOX6 (plus or minus bevacizumab) plus
527. Sofocleous CT, Violari EG, Sotirchos VS, et al. Radioembolization as selective internal radiation therapy in patients with metastatic colorectal
a salvage therapy for heavily pretreated patients with colorectal cancer cancer. J Clin Oncol 2016;34:1723-1731. Available at:
liver metastases: factors that affect outcomes. Clin Colorectal Cancer http://www.ncbi.nlm.nih.gov/pubmed/26903575.
2015;14:296-305. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/26277696. 534. Garlipp B, Gibbs P, Van Hazel GA, et al. Secondary technical
resectability of colorectal cancer liver metastases after chemotherapy with
528. Hickey R, Lewandowski RJ, Prudhomme T, et al. 90Y or without selective internal radiotherapy in the randomized SIRFLOX trial.
radioembolization of colorectal hepatic metastases using glass Br J Surg 2019;106:1837-1846. Available at:
microspheres: safety and survival outcomes from a 531-patient multicenter https://www.ncbi.nlm.nih.gov/pubmed/31424576.
study. J Nucl Med 2016;57:665-671. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/26635340. 535. Wasan HS, Gibbs P, Sharma NK, et al. First-line selective internal
radiotherapy plus chemotherapy versus chemotherapy alone in patients
529. Kurilova I, Beets-Tan RGH, Flynn J, et al. Factors Affecting with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and
Oncologic Outcomes of 90Y Radioembolization of Heavily Pre-Treated FOXFIRE-Global): a combined analysis of three multicentre, randomised,
Patients With Colon Cancer Liver Metastases. Clin Colorectal Cancer phase 3 trials. Lancet Oncol 2017;18:1159-1171. Available at:
2019;18:8-18. Available at: https://www.ncbi.nlm.nih.gov/pubmed/28781171.
https://www.ncbi.nlm.nih.gov/pubmed/30297264.

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NCCN Guidelines Version 4.2024

Rectal Cancer

536. Gibbs P, Heinemann V, Sharma NK, et al. Effect of Primary Tumor 543. Scheffer HJ, Vroomen LG, Nielsen K, et al. Colorectal liver metastatic
Side on Survival Outcomes in Untreated Patients With Metastatic disease: efficacy of irreversible electroporation--a single-arm phase II
Colorectal Cancer When Selective Internal Radiation Therapy Is Added to clinical trial (COLDFIRE-2 trial). BMC Cancer 2015;15:772. Available at:
Chemotherapy: Combined Analysis of Two Randomized Controlled https://www.ncbi.nlm.nih.gov/pubmed/26497813.
Studies. Clin Colorectal Cancer 2018;17:e617-e629. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/30033117. 544. Elias D, De Baere T, Smayra T, et al. Percutaneous radiofrequency
thermoablation as an alternative to surgery for treatment of liver tumour
537. Rosenbaum CE, Verkooijen HM, Lam MG, et al. Radioembolization recurrence after hepatectomy. Br J Surg 2002;89:752-756. Available at:
for treatment of salvage patients with colorectal cancer liver metastases: a http://www.ncbi.nlm.nih.gov/pubmed/12027986.
systematic review. J Nucl Med 2013;54:1890-1895. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24071510. 545. Sofocleous CT, Petre EN, Gonen M, et al. CT-guided radiofrequency
ablation as a salvage treatment of colorectal cancer hepatic metastases
538. Saxena A, Bester L, Shan L, et al. A systematic review on the safety developing after hepatectomy. J Vasc Interv Radiol 2011;22:755-761.
and efficacy of yttrium-90 radioembolization for unresectable, Available at: http://www.ncbi.nlm.nih.gov/pubmed/21514841.
chemorefractory colorectal cancer liver metastases. J Cancer Res Clin
Oncol 2014;140:537-547. Available at: 546. Sucandy I, Cheek S, Golas BJ, et al. Longterm survival outcomes of
http://www.ncbi.nlm.nih.gov/pubmed/24318568. patients undergoing treatment with radiofrequency ablation for
hepatocellular carcinoma and metastatic colorectal cancer liver tumors.
539. Townsend A, Price T, Karapetis C. Selective internal radiation HPB (Oxford) 2016;18:756-763. Available at:
therapy for liver metastases from colorectal cancer. Cochrane Database http://www.ncbi.nlm.nih.gov/pubmed/27593593.
Syst Rev 2009:CD007045. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/19821394. 547. de Jong MC, Pulitano C, Ribero D, et al. Rates and patterns of
recurrence following curative intent surgery for colorectal liver metastasis:
540. Abdalla EK. Commentary: Radiofrequency ablation for colorectal liver an international multi-institutional analysis of 1669 patients. Ann Surg
metastases: do not blame the biology when it is the technology. Am J Surg 2009;250:440-448. Available at:
2009;197:737-739. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19730175.
http://www.ncbi.nlm.nih.gov/pubmed/18789420.
548. Gillams A, Khan Z, Osborn P, Lees W. Survival after radiofrequency
541. Correa-Gallego C, Gonen M, Fischer M, et al. Perioperative ablation in 122 patients with inoperable colorectal lung metastases.
complications influence recurrence and survival after resection of hepatic Cardiovasc Intervent Radiol 2013;36:724-730. Available at:
colorectal metastases. Ann Surg Oncol 2013;20:2477-2484. Available at: http://www.ncbi.nlm.nih.gov/pubmed/23070108.
https://www.ncbi.nlm.nih.gov/pubmed/23608971.
549. Gleisner AL, Choti MA, Assumpcao L, et al. Colorectal liver
542. Wang X, Sofocleous CT, Erinjeri JP, et al. Margin size is an metastases: recurrence and survival following hepatic resection,
independent predictor of local tumor progression after ablation of colon radiofrequency ablation, and combined resection-radiofrequency ablation.
cancer liver metastases. Cardiovasc Intervent Radiol 2013;36:166-175. Arch Surg 2008;143:1204-1212. Available at:
Available at: http://www.ncbi.nlm.nih.gov/pubmed/22535243. http://www.ncbi.nlm.nih.gov/pubmed/19075173.

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NCCN Guidelines Version 4.2024

Rectal Cancer

550. Reuter NP, Woodall CE, Scoggins CR, et al. Radiofrequency ablation 558. Wong SL, Mangu PB, Choti MA, et al. American Society of Clinical
vs. resection for hepatic colorectal metastasis: therapeutically equivalent? Oncology 2009 clinical evidence review on radiofrequency ablation of
J Gastrointest Surg 2009;13:486-491. Available at: hepatic metastases from colorectal cancer. J Clin Oncol 2010;28:493-508.
http://www.ncbi.nlm.nih.gov/pubmed/18972167. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19841322.

551. Ruers T, Punt C, Van Coevorden F, et al. Radiofrequency ablation 559. Shady W, Petre EN, Do KG, et al. Percutaneous Microwave versus
combined with systemic treatment versus systemic treatment alone in Radiofrequency Ablation of Colorectal Liver Metastases: Ablation with
patients with non-resectable colorectal liver metastases: a randomized Clear Margins (A0) Provides the Best Local Tumor Control. J Vasc Interv
EORTC Intergroup phase II study (EORTC 40004). Ann Oncol Radiol 2018;29:268-275.e261. Available at:
2012;23:2619-2626. Available at: https://www.ncbi.nlm.nih.gov/pubmed/29203394.
http://www.ncbi.nlm.nih.gov/pubmed/22431703.
560. Meijerink MR, Puijk RS, van Tilborg A, et al. Radiofrequency and
552. Bala MM, Riemsma RP, Wolff R, Kleijnen J. Microwave coagulation Microwave Ablation Compared to Systemic Chemotherapy and to Partial
for liver metastases. Cochrane Database Syst Rev 2013;10:CD010163. Hepatectomy in the Treatment of Colorectal Liver Metastases: A
Available at: http://www.ncbi.nlm.nih.gov/pubmed/24122576. Systematic Review and Meta-Analysis. Cardiovasc Intervent Radiol
2018;41:1189-1204. Available at:
553. Bala MM, Riemsma RP, Wolff R, Kleijnen J. Cryotherapy for liver https://www.ncbi.nlm.nih.gov/pubmed/29666906.
metastases. Cochrane Database Syst Rev 2013;6:CD009058. Available
at: http://www.ncbi.nlm.nih.gov/pubmed/23740609. 561. Odisio BC, Yamashita S, Huang SY, et al. Local tumour progression
after percutaneous ablation of colorectal liver metastases according to
554. Cirocchi R, Trastulli S, Boselli C, et al. Radiofrequency ablation in the RAS mutation status. Br J Surg 2017;104:760-768. Available at:
treatment of liver metastases from colorectal cancer. Cochrane Database https://www.ncbi.nlm.nih.gov/pubmed/28240361.
Syst Rev 2012;6:CD006317. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/22696357. 562. Calandri M, Yamashita S, Gazzera C, et al. Ablation of colorectal liver
metastasis: Interaction of ablation margins and RAS mutation profiling on
555. Riemsma RP, Bala MM, Wolff R, Kleijnen J. Percutaneous ethanol local tumour progression-free survival. Eur Radiol 2018;28:2727-2734.
injection for liver metastases. Cochrane Database Syst Rev Available at: https://www.ncbi.nlm.nih.gov/pubmed/29417253.
2013;5:CD008717. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/23728679. 563. Shady W, Petre EN, Vakiani E, et al. Kras mutation is a marker of
worse oncologic outcomes after percutaneous radiofrequency ablation of
556. Riemsma RP, Bala MM, Wolff R, Kleijnen J. Electro-coagulation for colorectal liver metastases. Oncotarget 2017;8:66117-66127. Available at:
liver metastases. Cochrane Database Syst Rev 2013;5:CD009497. https://www.ncbi.nlm.nih.gov/pubmed/29029497.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/23728692.
564. de Baere T, Auperin A, Deschamps F, et al. Radiofrequency ablation
557. Weng M, Zhang Y, Zhou D, et al. Radiofrequency ablation versus is a valid treatment option for lung metastases: experience in 566 patients
resection for colorectal cancer liver metastases: a meta-analysis. PLoS with 1037 metastases. Ann Oncol 2015;26:987-991. Available at:
One 2012;7:e45493. Available at: https://www.ncbi.nlm.nih.gov/pubmed/25688058.
http://www.ncbi.nlm.nih.gov/pubmed/23029051.

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Rectal Cancer

565. Kurilova I, Gonzalez-Aguirre A, Beets-Tan RG, et al. Microwave 2007;6:348-356. Available at:
Ablation in the Management of Colorectal Cancer Pulmonary Metastases. http://www.ncbi.nlm.nih.gov/pubmed/17311699.
Cardiovasc Intervent Radiol 2018;41:1530-1544. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/29845348. 573. Topkan E, Onal HC, Yavuz MN. Managing liver metastases with
conformal radiation therapy. J Support Oncol 2008;6:9-13, 15. Available
566. Callstrom MR, Woodrum DA, Nichols FC, et al. Multicenter Study of at: http://www.ncbi.nlm.nih.gov/pubmed/18257395.
Metastatic Lung Tumors Targeted by Interventional Cryoablation
Evaluation (SOLSTICE). J Thorac Oncol 2020;15:1200-1209. Available at: 574. Ahmed KA, Caudell JJ, El-Haddad G, et al. Radiosensitivity
https://www.ncbi.nlm.nih.gov/pubmed/32151777. Differences Between Liver Metastases Based on Primary Histology
Suggest Implications for Clinical Outcomes After Stereotactic Body
567. Fonck M, Perez JT, Catena V, et al. Pulmonary Thermal Ablation Radiation Therapy. Int J Radiat Oncol Biol Phys 2016;95:1399-1404.
Enables Long Chemotherapy-Free Survival in Metastatic Colorectal Available at: https://www.ncbi.nlm.nih.gov/pubmed/27319288.
Cancer Patients. Cardiovasc Intervent Radiol 2018;41:1727-1734.
Available at: https://www.ncbi.nlm.nih.gov/pubmed/29766240. 575. Ahmed KA, Scott JG, Arrington JA, et al. Radiosensitivity of Lung
Metastases by Primary Histology and Implications for Stereotactic Body
568. Agolli L, Bracci S, Nicosia L, et al. Lung metastases treated with Radiation Therapy Using the Genomically Adjusted Radiation Dose. J
stereotactic ablative radiation therapy in oligometastatic colorectal cancer Thorac Oncol 2018;13:1121-1127. Available at:
patients: outcomes and prognostic factors after long-term follow-up. Clin https://www.ncbi.nlm.nih.gov/pubmed/29733909.
Colorectal Cancer 2016;16:58-64. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/27522627. 576. Joo JH, Park JH, Kim JC, et al. Local Control Outcomes Using
Stereotactic Body Radiation Therapy for Liver Metastases From Colorectal
569. Chang DT, Swaminath A, Kozak M, et al. Stereotactic body Cancer. Int J Radiat Oncol Biol Phys 2017;99:876-883. Available at:
radiotherapy for colorectal liver metastases: a pooled analysis. Cancer https://www.ncbi.nlm.nih.gov/pubmed/29063852.
2011;117:4060-4069. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/21432842. 577. Siva S, MacManus M, Ball D. Stereotactic radiotherapy for pulmonary
oligometastases: a systematic review. J Thorac Oncol 2010;5:1091-1099.
570. ACR practice parameter for intensity modulated radiation therapy Available at: https://www.ncbi.nlm.nih.gov/pubmed/20479693.
(IMRT). The American College of Radiology; 2016. Available at:
https://www.acr.org/-/media/ACR/Files/Practice-Parameters/imrt- 578. Helou J, Thibault I, Poon I, et al. Stereotactic Ablative Radiation
ro.pdf?la=en. Accessed June 23, 2020. Therapy for Pulmonary Metastases: Histology, Dose, and Indication
Matter. Int J Radiat Oncol Biol Phys 2017;98:419-427. Available at:
571. Hong TS, Ritter MA, Tome WA, Harari PM. Intensity-modulated https://www.ncbi.nlm.nih.gov/pubmed/28463162.
radiation therapy: emerging cancer treatment technology. Br J Cancer
2005;92:1819-1824. Available at: 579. Palma DA, Olson R, Harrow S, et al. Stereotactic Ablative
http://www.ncbi.nlm.nih.gov/pubmed/15856036. Radiotherapy for the Comprehensive Treatment of Oligometastatic
Cancers: Long-Term Results of the SABR-COMET Phase II Randomized
572. Meyer J, Czito B, Yin F-F, Willett C. Advanced radiation therapy Trial. J Clin Oncol 2020;38:2830-2838. Available at:
technologies in the treatment of rectal and anal cancer: intensity- https://www.ncbi.nlm.nih.gov/pubmed/32484754.
modulated photon therapy and proton therapy. Clin Colorectal Cancer

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NCCN Guidelines Version 4.2024

Rectal Cancer

580. Franko J, Shi Q, Meyers JP, et al. Prognosis of patients with 587. Altendorf-Hofmann A, Scheele J. A critical review of the major
peritoneal metastatic colorectal cancer given systemic therapy: an indicators of prognosis after resection of hepatic metastases from
analysis of individual patient data from prospective randomised trials from colorectal carcinoma. Surg Oncol Clin N Am 2003;12:165-192. Available
the Analysis and Research in Cancers of the Digestive System (ARCAD) at: http://www.ncbi.nlm.nih.gov/pubmed/12735137.
database. Lancet Oncol 2016;17:1709-1719. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/27743922. 588. Pawlik TM, Schulick RD, Choti MA. Expanding criteria for
resectability of colorectal liver metastases. Oncologist 2008;13:51-64.
581. Klaver YL, Leenders BJ, Creemers GJ, et al. Addition of biological Available at: http://www.ncbi.nlm.nih.gov/pubmed/18245012.
therapies to palliative chemotherapy prolongs survival in patients with
peritoneal carcinomatosis of colorectal origin. Am J Clin Oncol 589. Pozzo C, Basso M, Cassano A, et al. Neoadjuvant treatment of
2013;36:157-161. Available at: unresectable liver disease with irinotecan and 5-fluorouracil plus folinic
http://www.ncbi.nlm.nih.gov/pubmed/22314003. acid in colorectal cancer patients. Ann Oncol 2004;15:933-939. Available
at: http://www.ncbi.nlm.nih.gov/pubmed/15151951.
582. Takahashi H, Okabayashi K, Tsuruta M, et al. Self-expanding metallic
stents versus surgical intervention as palliative therapy for obstructive 590. Vauthey J-N, Zorzi D, Pawlik TM. Making unresectable hepatic
colorectal cancer: a meta-analysis. World J Surg 2015;39:2037-2044. colorectal metastases resectable--does it work? Semin Oncol
Available at: http://www.ncbi.nlm.nih.gov/pubmed/25894403. 2005;32:118-122. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/16399448.
583. van Hooft JE, van Halsema EE, Vanbiervliet G, et al. Self-expandable
metal stents for obstructing colonic and extracolonic cancer: European 591. Covey AM, Brown KT, Jarnagin WR, et al. Combined portal vein
Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. embolization and neoadjuvant chemotherapy as a treatment strategy for
Gastrointest Endosc 2014;80:747-761 e741-775. Available at: resectable hepatic colorectal metastases. Ann Surg 2008;247:451-455.
http://www.ncbi.nlm.nih.gov/pubmed/25436393. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18376189.

584. Fiori E, Crocetti D, Lamazza A, et al. Resection or Stenting in the 592. Folprecht G, Grothey A, Alberts S, et al. Neoadjuvant treatment of
Treatment of Symptomatic Advanced Metastatic Rectal Cancer: A unresectable colorectal liver metastases: correlation between tumour
Dilemma. Anticancer Res 2019;39:6781-6786. Available at: response and resection rates. Ann Oncol 2005;16:1311-1319. Available
https://www.ncbi.nlm.nih.gov/pubmed/31810943. at: http://www.ncbi.nlm.nih.gov/pubmed/15870084.

585. Cennamo V, Fuccio L, Mutri V, et al. Does stent placement for 593. Bilchik AJ, Poston G, Curley SA, et al. Neoadjuvant chemotherapy for
advanced colon cancer increase the risk of perforation during metastatic colon cancer: a cautionary note. J Clin Oncol 2005;23:9073-
bevacizumab-based therapy? Clin Gastroenterol Hepatol 2009;7:1174- 9078. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16361615.
1176. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19631290.
594. Choti MA. Chemotherapy-associated hepatotoxicity: do we need to
586. Small AJ, Coelho-Prabhu N, Baron TH. Endoscopic placement of be concerned? Ann Surg Oncol 2009;16:2391-2394. Available at:
self-expandable metal stents for malignant colonic obstruction: long-term http://www.ncbi.nlm.nih.gov/pubmed/19554374.
outcomes and complication factors. Gastrointest Endosc 2010;71:560-
572. Available at: http://www.ncbi.nlm.nih.gov/pubmed/20189515. 595. Kishi Y, Zorzi D, Contreras CM, et al. Extended preoperative
chemotherapy does not improve pathologic response and increases

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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NCCN Guidelines Version 4.2024

Rectal Cancer

postoperative liver insufficiency after hepatic resection for colorectal liver 602. Masi G, Vasile E, Loupakis F, et al. Randomized trial of two induction
metastases. Ann Surg Oncol 2010;17:2870-2876. Available at: chemotherapy regimens in metastatic colorectal cancer: an updated
http://www.ncbi.nlm.nih.gov/pubmed/20567921. analysis. J Natl Cancer Inst 2011;103:21-30. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/21123833.
596. Rubbia-Brandt L, Audard V, Sartoretti P, et al. Severe hepatic
sinusoidal obstruction associated with oxaliplatin-based chemotherapy in 603. Adam R, Avisar E, Ariche A, et al. Five-year survival following hepatic
patients with metastatic colorectal cancer. Ann Oncol 2004;15:460-466. resection after neoadjuvant therapy for nonresectable colorectal. Ann Surg
Available at: http://www.ncbi.nlm.nih.gov/pubmed/14998849. Oncol 2001;8:347-353. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/11352309.
597. Vauthey J-N, Pawlik TM, Ribero D, et al. Chemotherapy regimen
predicts steatohepatitis and an increase in 90-day mortality after surgery 604. Pawlik TM, Olino K, Gleisner AL, et al. Preoperative chemotherapy
for hepatic colorectal metastases. J Clin Oncol 2006;24:2065-2072. for colorectal liver metastases: impact on hepatic histology and
Available at: http://www.ncbi.nlm.nih.gov/pubmed/16648507. postoperative outcome. J Gastrointest Surg 2007;11:860-868. Available
at: http://www.ncbi.nlm.nih.gov/pubmed/17492335.
598. Zhao J, van Mierlo KMC, Gomez-Ramirez J, et al. Systematic review
of the influence of chemotherapy-associated liver injury on outcome after 605. Rivoire M, De Cian F, Meeus P, et al. Combination of neoadjuvant
partial hepatectomy for colorectal liver metastases. Br J Surg chemotherapy with cryotherapy and surgical resection for the treatment of
2017;104:990-1002. Available at: unresectable liver metastases from colorectal carcinoma. Cancer
https://www.ncbi.nlm.nih.gov/pubmed/28542731. 2002;95:2283-2292. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/12436433.
599. Delaunoit T, Alberts SR, Sargent DJ, et al. Chemotherapy permits
resection of metastatic colorectal cancer: experience from Intergroup 606. van Mierlo KM, Zhao J, Kleijnen J, et al. The influence of
N9741. Ann Oncol 2005;16:425-429. Available at: chemotherapy-associated sinusoidal dilatation on short-term outcome
http://www.ncbi.nlm.nih.gov/pubmed/15677624. after partial hepatectomy for colorectal liver metastases: A systematic
review with meta-analysis. Surg Oncol 2016;25:298-307. Available at:
600. Falcone A, Ricci S, Brunetti I, et al. Phase III trial of infusional https://www.ncbi.nlm.nih.gov/pubmed/27566036.
fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared
with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first- 607. Scappaticci FA, Fehrenbacher L, Cartwright T, et al. Surgical wound
line treatment for metastatic colorectal cancer: the Gruppo Oncologico healing complications in metastatic colorectal cancer patients treated with
Nord Ovest. J Clin Oncol 2007;25:1670-1676. Available at: bevacizumab. J Surg Oncol 2005;91:173-180. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/17470860. http://www.ncbi.nlm.nih.gov/pubmed/16118771.

601. Souglakos J, Androulakis N, Syrigos K, et al. FOLFOXIRI (folinic 608. Snoeren N, van Hillegersberg R, Schouten SB, et al. Randomized
acid, 5-fluorouracil, oxaliplatin and irinotecan) vs FOLFIRI (folinic acid, 5- phase iii study to assess efficacy and safety of adjuvant CAPOX with or
fluorouracil and irinotecan) as first-line treatment in metastatic colorectal without bevacizumab in patients after resection of colorectal liver
cancer (MCC): a multicentre randomised phase III trial from the Hellenic metastases: HEPATICA study. Neoplasia 2017;19:93-99. Available at:
Oncology Research Group (HORG). Br J Cancer 2006;94:798-805. https://www.ncbi.nlm.nih.gov/pubmed/28088688.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/16508637.

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Rectal Cancer

609. Ranpura V, Hapani S, Wu S. Treatment-related mortality with 616. Tang W, Ren L, Liu T, et al. Bevacizumab Plus mFOLFOX6 Versus
bevacizumab in cancer patients: a meta-analysis. JAMA 2011;305:487- mFOLFOX6 Alone as First-Line Treatment for RAS Mutant Unresectable
494. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21285426. Colorectal Liver-Limited Metastases: The BECOME Randomized
Controlled Trial. J Clin Oncol 2020;38:3175-3184. Available at:
610. Hurwitz HI, Saltz LB, Van Cutsem E, et al. Venous thromboembolic https://www.ncbi.nlm.nih.gov/pubmed/32749938.
events with chemotherapy plus bevacizumab: a pooled analysis of
patients in randomized phase II and III studies. J Clin Oncol 617. Moretto R, Rossini D, Zucchelli G, et al. Oligometastatic colorectal
2011;29:1757-1764. Available at: cancer: prognosis, role of locoregional treatments and impact of first-line
http://www.ncbi.nlm.nih.gov/pubmed/21422411. chemotherapy-a pooled analysis of TRIBE and TRIBE2 studies by Gruppo
Oncologico del Nord Ovest. Eur J Cancer 2020;139:81-89. Available at:
611. Dai F, Shu L, Bian Y, et al. Safety of bevacizumab in treating https://pubmed.ncbi.nlm.nih.gov/32979645/.
metastatic colorectal cancer: a systematic review and meta-analysis of all
randomized clinical trials. Clin Drug Investig 2013;33:779-788. Available 618. Cremolini C, Antoniotti C, Stein A, et al. Individual Patient Data Meta-
at: http://www.ncbi.nlm.nih.gov/pubmed/23979925. Analysis of FOLFOXIRI Plus Bevacizumab Versus Doublets Plus
Bevacizumab as Initial Therapy of Unresectable Metastatic Colorectal
612. Hochster HS, Hart LL, Ramanathan RK, et al. Safety and efficacy of Cancer. J Clin Oncol 2020:Jco2001225. Available at:
oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as https://pubmed.ncbi.nlm.nih.gov/32816630/.
first-line treatment of metastatic colorectal cancer: results of the TREE
Study. J Clin Oncol 2008;26:3523-3529. Available at: 619. Folprecht G, Gruenberger T, Bechstein WO, et al. Tumour response
http://www.ncbi.nlm.nih.gov/pubmed/18640933. and secondary resectability of colorectal liver metastases following
neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase
613. U.S. Food & Drug Administration Package Insert. bevacizumab 2 trial. Lancet Oncol 2010;11:38-47. Available at:
injection, for intravenous use. 2022. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19942479.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/125085s340l
bl.pdf. Accessed February 13, 2023. 620. Folprecht G, Gruenberger T, Bechstein W, et al. Survival of patients
with initially unresectable colorectal liver metastases treated with
614. Fuchs CS, Marshall J, Mitchell E, et al. Randomized, controlled trial FOLFOX/cetuximab or FOLFIRI/cetuximab in a multidisciplinary concept
of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line (CELIM study). Ann Oncol 2014;25:1018-1025. Available at:
treatment of metastatic colorectal cancer: results from the BICC-C Study. http://www.ncbi.nlm.nih.gov/pubmed/24585720.
J Clin Oncol 2007;25:4779-4786. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/17947725. 621. Ye LC, Liu TS, Ren L, et al. Randomized controlled trial of cetuximab
plus chemotherapy for patients with KRAS wild-type unresectable
615. Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination colorectal liver-limited metastases. J Clin Oncol 2013;31:1931-1938.
with oxaliplatin-based chemotherapy as first-line therapy in metastatic Available at: http://www.ncbi.nlm.nih.gov/pubmed/23569301.
colorectal cancer: a randomized phase III study. J Clin Oncol
2008;26:2013-2019. Available at: 622. Modest DP, Martens UM, Riera-Knorrenschild J, et al. FOLFOXIRI
http://www.ncbi.nlm.nih.gov/pubmed/18421054. Plus Panitumumab As First-Line Treatment of RAS Wild-Type Metastatic
Colorectal Cancer: The Randomized, Open-Label, Phase II VOLFI Study

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(AIO KRK0109). J Clin Oncol 2019;37:3401-3411. Available at: systematic review and meta-analysis of randomized controlled trials.
https://pubmed.ncbi.nlm.nih.gov/31609637/. Oncol Rep 2012;27:1849-1856. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/22446591.
623. Petrelli F, Barni S. Resectability and outcome with anti-EGFR agents
in patients with KRAS wild-type colorectal liver-limited metastases: a 630. Wang ZM, Chen YY, Chen FF, et al. Peri-operative chemotherapy for
meta-analysis. Int J Colorectal Dis 2012;27:997-1004. Available at: patients with resectable colorectal hepatic metastasis: A meta-analysis.
http://www.ncbi.nlm.nih.gov/pubmed/22358385. Eur J Surg Oncol 2015;41:1197-1203. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/26094113.
624. Rossini D, Antoniotti C, Lonardi S, et al. Upfront Modified
Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan Plus Panitumumab 631. Araujo R, Gonen M, Allen P, et al. Comparison between perioperative
Versus Fluorouracil, Leucovorin, and Oxaliplatin Plus Panitumumab for and postoperative chemotherapy after potentially curative hepatic
Patients With RAS/BRAF Wild-Type Metastatic Colorectal Cancer: The resection for metastatic colorectal cancer. Ann Surg Oncol 2013;20:4312-
Phase III TRIPLETE Study by GONO. J Clin Oncol 2022;40:2878-2888. 4321. Available at: http://www.ncbi.nlm.nih.gov/pubmed/23897009.
Available at: https://www.ncbi.nlm.nih.gov/pubmed/35666229.
632. Khoo E, O'Neill S, Brown E, et al. Systematic review of systemic
625. Borelli B, Moretto R, Lonardi S, et al. TRIPLETE: a randomised adjuvant, neoadjuvant and perioperative chemotherapy for resectable
phase III study of modified FOLFOXIRI plus panitumumab versus colorectal-liver metastases. HPB (Oxford) 2016;18:485-493. Available at:
mFOLFOX6 plus panitumumab as initial therapy for patients with https://www.ncbi.nlm.nih.gov/pubmed/27317952.
unresectable RAS and BRAF wild-type metastatic colorectal cancer.
ESMO Open 2018;3:e000403. Available at: 633. Brandi G, De Lorenzo S, Nannini M, et al. Adjuvant chemotherapy for
https://pubmed.ncbi.nlm.nih.gov/30018814/. resected colorectal cancer metastases: Literature review and meta-
analysis. World J Gastroenterol 2016;22:519-533. Available at:
626. Zhang J, Cai J, Deng Y, Wang H. Complete response in patients with https://www.ncbi.nlm.nih.gov/pubmed/26811604.
locally advanced rectal cancer after neoadjuvant treatment with
nivolumab. Oncoimmunology 2019;8:e1663108. Available at: 634. Nordlinger B, Sorbye H, Glimelius B, et al. Perioperative
https://pubmed.ncbi.nlm.nih.gov/31741760/. chemotherapy with FOLFOX4 and surgery versus surgery alone for
resectable liver metastases from colorectal cancer (EORTC Intergroup
627. Demisse R, Damle N, Kim E, et al. Neoadjuvant Immunotherapy- trial 40983): a randomised controlled trial. Lancet 2008;371:1007-1016.
Based Systemic Treatment in MMR-Deficient or MSI-High Rectal Cancer: Available at: http://www.ncbi.nlm.nih.gov/pubmed/18358928.
Case Series. J Natl Compr Canc Netw 2020;18:798-804. Available at:
https://pubmed.ncbi.nlm.nih.gov/32634770/. 635. Nordlinger B, Sorbye H, Glimelius B, et al. Perioperative FOLFOX4
chemotherapy and surgery versus surgery alone for resectable liver
628. Baimas-George M, Baker E, Kamionek M, et al. A Complete metastases from colorectal cancer (EORTC 40983): long-term results of a
Pathological Response to Pembrolizumab following ex vivo Liver randomised, controlled, phase 3 trial. Lancet Oncol 2013;14:1208-1215.
Resection in a Patient with Colorectal Liver Metastases. Chemotherapy Available at: http://www.ncbi.nlm.nih.gov/pubmed/24120480.
2018;63:90-94. Available at: https://pubmed.ncbi.nlm.nih.gov/29621772/.
636. Nagayama S, Hasegawa S, Hida K, et al. Multi-institutional phase II
629. Ciliberto D, Prati U, Roveda L, et al. Role of systemic chemotherapy study on the feasibility of liver resection following preoperative
in the management of resected or resectable colorectal liver metastases: a mFOLFOX6 therapy for resectable liver metastases from colorectal

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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Rectal Cancer

cancers. Int J Clin Oncol 2017;22:316-323. Available at: 644. Goldberg RM, Rothenberg ML, Van Cutsem E, et al. The continuum
https://www.ncbi.nlm.nih.gov/pubmed/27752787. of care: a paradigm for the management of metastatic colorectal cancer.
Oncologist 2007;12:38-50. Available at:
637. Primrose J, Falk S, Finch-Jones M, et al. Systemic chemotherapy http://www.ncbi.nlm.nih.gov/pubmed/17227899.
with or without cetuximab in patients with resectable colorectal liver
metastasis: the New EPOC randomised controlled trial. Lancet Oncol 645. Adam R, Miller R, Pitombo M, et al. Two-stage hepatectomy
2014;15:601-611. Available at: approach for initially unresectable colorectal hepatic metastases. Surg
http://www.ncbi.nlm.nih.gov/pubmed/24717919. Oncol Clin N Am 2007;16:525-536. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/17606192.
638. Bridgewater JA, Pugh SA, Maishman T, et al. Systemic
chemotherapy with or without cetuximab in patients with resectable 646. Boostrom SY, Vassiliki LT, Nagorney DM, et al. Synchronous rectal
colorectal liver metastasis (New EPOC): long-term results of a multicentre, and hepatic resection of rectal metastatic disease. J Gastrointest Surg
randomised, controlled, phase 3 trial. Lancet Oncol 2020;21:398-411. 2011;15:1583-1588. Available at:
Available at: https://www.ncbi.nlm.nih.gov/pubmed/32014119. http://www.ncbi.nlm.nih.gov/pubmed/21748454.

639. Bilchik AJ, Poston G, Adam R, Choti MA. Prognostic variables for 647. Chen J, Li Q, Wang C, et al. Simultaneous vs. staged resection for
resection of colorectal cancer hepatic metastases: an evolving paradigm. J synchronous colorectal liver metastases: a metaanalysis. Int J Colorectal
Clin Oncol 2008;26:5320-5321. Available at: Dis 2011;26:191-199. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/18936470. http://www.ncbi.nlm.nih.gov/pubmed/20669024.

640. Leonard GD, Brenner B, Kemeny NE. Neoadjuvant chemotherapy 648. Lykoudis PM, O'Reilly D, Nastos K, Fusai G. Systematic review of
before liver resection for patients with unresectable liver metastases from surgical management of synchronous colorectal liver metastases. Br J
colorectal carcinoma. J Clin Oncol 2005;23:2038-2048. Available at: Surg 2014;101:605-612. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/15774795. http://www.ncbi.nlm.nih.gov/pubmed/24652674.

641. van Vledder MG, de Jong MC, Pawlik TM, et al. Disappearing 649. Mayo SC, Pulitano C, Marques H, et al. Surgical management of
colorectal liver metastases after chemotherapy: should we be concerned? patients with synchronous colorectal liver metastasis: a multicenter
J Gastrointest Surg 2010;14:1691-1700. Available at: international analysis. J Am Coll Surg 2013;216:707-716; discussion 716-
http://www.ncbi.nlm.nih.gov/pubmed/20839072. 708. Available at: http://www.ncbi.nlm.nih.gov/pubmed/23433970.

642. Benoist S, Brouquet A, Penna C, et al. Complete response of 650. Slesser AA, Simillis C, Goldin R, et al. A meta-analysis comparing
colorectal liver metastases after chemotherapy: does it mean cure? J Clin simultaneous versus delayed resections in patients with synchronous
Oncol 2006;24:3939-3945. Available at: colorectal liver metastases. Surg Oncol 2013;22:36-47. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/16921046. http://www.ncbi.nlm.nih.gov/pubmed/23253399.

643. Bischof DA, Clary BM, Maithel SK, Pawlik TM. Surgical management 651. Worni M, Mantyh CR, Akushevich I, et al. Is there a role for
of disappearing colorectal liver metastases. Br J Surg 2013;100:1414- simultaneous hepatic and colorectal resections? A contemporary view
1420. Available at: http://www.ncbi.nlm.nih.gov/pubmed/24037559. from NSQIP. J Gastrointest Surg 2012;16:2074-2085. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/22972010.

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Rectal Cancer

652. Reddy SK, Pawlik TM, Zorzi D, et al. Simultaneous resections of 659. Karoui M, Roudot-Thoraval F, Mesli F, et al. Primary colectomy in
colorectal cancer and synchronous liver metastases: a multi-institutional patients with stage IV colon cancer and unresectable distant metastases
analysis. Ann Surg Oncol 2007;14:3481-3491. Available at: improves overall survival: results of a multicentric study. Dis Colon Rectum
http://www.ncbi.nlm.nih.gov/pubmed/17805933. 2011;54:930-938. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/21730780.
653. De Rosa A, Gomez D, Brooks A, Cameron IC. "Liver-first" approach
for synchronous colorectal liver metastases: is this a justifiable approach? 660. Venderbosch S, de Wilt JH, Teerenstra S, et al. Prognostic value of
J Hepatobiliary Pancreat Sci 2013;20:263-270. Available at: resection of primary tumor in patients with stage IV colorectal cancer:
http://www.ncbi.nlm.nih.gov/pubmed/23325126. retrospective analysis of two randomized studies and a review of the
literature. Ann Surg Oncol 2011;18:3252-3260. Available at:
654. Jegatheeswaran S, Mason JM, Hancock HC, Siriwardena AK. The http://www.ncbi.nlm.nih.gov/pubmed/21822557.
liver-first approach to the management of colorectal cancer with
synchronous hepatic metastases: a systematic review. JAMA Surg 661. Ishihara S, Nishikawa T, Tanaka T, et al. Benefit of primary tumor
2013;148:385-391. Available at: resection in stage IV colorectal cancer with unresectable metastasis: a
http://www.ncbi.nlm.nih.gov/pubmed/23715907. multicenter retrospective study using a propensity score analysis. Int J
Colorectal Dis 2015;30:807-812. Available at:
655. Lam VW, Laurence JM, Pang T, et al. A systematic review of a liver- http://www.ncbi.nlm.nih.gov/pubmed/25922146.
first approach in patients with colorectal cancer and synchronous
colorectal liver metastases. HPB (Oxford) 2014;16:101-108. Available at: 662. Ahmed S, Shahid RK, Leis A, et al. Should noncurative resection of
http://www.ncbi.nlm.nih.gov/pubmed/23509899. the primary tumour be performed in patients with stage iv colorectal
cancer? A systematic review and meta-analysis. Curr Oncol
656. Yoon HI, Koom WS, Kim TH, et al. Upfront systemic chemotherapy 2013;20:e420-441. Available at:
and short-course radiotherapy with delayed surgery for locally advanced http://www.ncbi.nlm.nih.gov/pubmed/24155639.
rectal cancer with distant metastases: outcomes, compliance, and
favorable prognostic factors. PLoS One 2016;11:e0161475. Available at: 663. Anwar S, Peter MB, Dent J, Scott NA. Palliative excisional surgery for
https://www.ncbi.nlm.nih.gov/pubmed/27536871. primary colorectal cancer in patients with incurable metastatic disease. Is
there a survival benefit? A systematic review. Colorectal Dis 2012;14:920-
657. Bartlett DL, Berlin J, Lauwers GY, et al. Chemotherapy and regional 930. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21899714.
therapy of hepatic colorectal metastases: expert consensus statement.
Ann Surg Oncol 2006;13:1284-1292. Available at: 664. Clancy C, Burke JP, Barry M, et al. A meta-analysis to determine the
http://www.ncbi.nlm.nih.gov/pubmed/16955384. effect of primary tumor resection for stage IV colorectal cancer with
unresectable metastases on patient survival. Ann Surg Oncol
658. Faron M, Pignon JP, Malka D, et al. Is primary tumour resection 2014;21:3900-3908. Available at:
associated with survival improvement in patients with colorectal cancer http://www.ncbi.nlm.nih.gov/pubmed/24849523.
and unresectable synchronous metastases? A pooled analysis of
individual data from four randomised trials. Eur J Cancer 2015;51:166- 665. Gulack BC, Nussbaum DP, Keenan JE, et al. Surgical resection of
176. Available at: http://www.ncbi.nlm.nih.gov/pubmed/25465185. the primary tumor in stage IV colorectal cancer without metastasectomy is
associated with improved overall survival compared with

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Rectal Cancer

chemotherapy/radiation therapy alone. Dis Colon Rectum 2016;59:299- 672. Ikoma N, You YN, Bednarski BK, et al. Impact of recurrence and
305. Available at: https://www.ncbi.nlm.nih.gov/pubmed/26953988. salvage surgery on survival after multidisciplinary treatment of rectal
cancer. J Clin Oncol 2017;35:2631-2638. Available at:
666. Tarantino I, Warschkow R, Worni M, et al. Prognostic relevance of https://www.ncbi.nlm.nih.gov/pubmed/28657814.
palliative primary tumor removal in 37,793 metastatic colorectal cancer
patients: a population-based, propensity score-adjusted trend analysis. 673. Joyce DL, Wahl RL, Patel PV, et al. Preoperative positron emission
Ann Surg 2015;262:112-120. Available at: tomography to evaluate potentially resectable hepatic colorectal
http://www.ncbi.nlm.nih.gov/pubmed/25373464. metastases. Arch Surg 2006;141:1220-1226; discussion 1227. Available
at: http://www.ncbi.nlm.nih.gov/pubmed/17178965.
667. Alawadi Z, Phatak UR, Hu CY, et al. Comparative effectiveness of
primary tumor resection in patients with stage IV colon cancer. Cancer 674. Pelosi E, Deandreis D. The role of 18F-fluoro-deoxy-glucose positron
2016;123:1124-1133. Available at: emission tomography (FDG-PET) in the management of patients with
https://www.ncbi.nlm.nih.gov/pubmed/27479827. colorectal cancer. Eur J Surg Oncol 2007;33:1-6. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/17126522.
668. Kanemitsu Y, Shitara K, Mizusawa J, et al. Primary Tumor Resection
Plus Chemotherapy Versus Chemotherapy Alone for Colorectal Cancer 675. Moulton CA, Gu CS, Law CH, et al. Effect of PET before liver
Patients With Asymptomatic, Synchronous Unresectable Metastases resection on surgical management for colorectal adenocarcinoma
(JCOG1007; iPACS): A Randomized Clinical Trial. J Clin Oncol metastases: a randomized clinical trial. JAMA 2014;311:1863-1869.
2021;39:1098-1107. Available at: Available at: http://www.ncbi.nlm.nih.gov/pubmed/24825641.
https://www.ncbi.nlm.nih.gov/pubmed/33560877.
676. Maffione AM, Lopci E, Bluemel C, et al. Diagnostic accuracy and
669. McCahill LE, Yothers G, Sharif S, et al. Primary mFOLFOX6 plus impact on management of (18)F-FDG PET and PET/CT in colorectal liver
bevacizumab without resection of the primary tumor for patients metastasis: a meta-analysis and systematic review. Eur J Nucl Med Mol
presenting with surgically unresectable metastatic colon cancer and an Imaging 2015;42:152-163. Available at:
intact asymptomatic colon cancer: definitive analysis of NSABP trial C-10. http://www.ncbi.nlm.nih.gov/pubmed/25319712.
J Clin Oncol 2012;30:3223-3228. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/22869888. 677. Gill S, Berry S, Biagi J, et al. Progression-free survival as a primary
endpoint in clinical trials of metastatic colorectal cancer. Curr Oncol
670. Cirocchi R, Trastulli S, Abraha I, et al. Non-resection versus resection 2011;18 Suppl 2:S5-S10. Available at:
for an asymptomatic primary tumour in patients with unresectable Stage IV http://www.ncbi.nlm.nih.gov/pubmed/21969810.
colorectal cancer. Cochrane Database Syst Rev 2012;8:CD008997.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/22895981. 678. Booth CM, Eisenhauer EA. Progression-free survival: meaningful or
simply measurable? J Clin Oncol 2012;30:1030-1033. Available at:
671. Yang TX, Billah B, Morris DL, Chua TC. Palliative resection of the http://www.ncbi.nlm.nih.gov/pubmed/22370321.
primary tumour in patients with Stage IV colorectal cancer: systematic
review and meta-analysis of the early outcome after laparoscopic and 679. Chibaudel B, Bonnetain F, Shi Q, et al. Alternative end points to
open colectomy. Colorectal Dis 2013;15:e407-419. Available at: evaluate a therapeutic strategy in advanced colorectal cancer: evaluation
http://www.ncbi.nlm.nih.gov/pubmed/23895669. of progression-free survival, duration of disease control, and time to failure
of strategy--an Aide et Recherche en Cancerologie Digestive Group

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Study. J Clin Oncol 2011;29:4199-4204. Available at: Dis Colon Rectum 1998;41:1127-1133. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/21969501. http://www.ncbi.nlm.nih.gov/pubmed/9749496.

680. Shi Q, de Gramont A, Grothey A, et al. Individual patient data 687. Rodriguez-Moranta F, Salo J, Arcusa A, et al. Postoperative
analysis of progression-free survival versus overall survival as a first-line surveillance in patients with colorectal cancer who have undergone
end point for metastatic colorectal cancer in modern randomized trials: curative resection: a prospective, multicenter, randomized, controlled trial.
findings from the analysis and research in cancers of the digestive system J Clin Oncol 2006;24:386-393. Available at:
database. J Clin Oncol 2015;33:22-28. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16365182.
http://www.ncbi.nlm.nih.gov/pubmed/25385741.
688. Secco GB, Fardelli R, Gianquinto D, et al. Efficacy and cost of risk-
681. Carrera G, Garcia-Albeniz X, Ayuso JR, et al. Design and endpoints adapted follow-up in patients after colorectal cancer surgery: a
of clinical and translational trials in advanced colorectal cancer. a proposal prospective, randomized and controlled trial. Eur J Surg Oncol
from GROUP Espanol Multidisciplinar en Cancer Digestivo (GEMCAD). 2002;28:418-423. Available at:
Rev Recent Clin Trials 2011;6:158-170. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12099653.
http://www.ncbi.nlm.nih.gov/pubmed/21241233.
689. Desch CE, Benson AB, Somerfield MR, et al. Colorectal cancer
682. Claret L, Gupta M, Han K, et al. Evaluation of tumor-size response surveillance: 2005 update of an American Society of Clinical Oncology
metrics to predict overall survival in Western and Chinese patients with Practice Guideline. J Clin Oncol 2005;23:8512-8519. Available at:
first-line metastatic colorectal cancer. J Clin Oncol 2013;31:2110-2114. http://www.ncbi.nlm.nih.gov/pubmed/16260687.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/23650411.
690. Jeffery M, Hickey BE, Hider PN, See AM. Follow-up strategies for
683. Sharma MR, Gray E, Goldberg RM, et al. Resampling the N9741 trial patients treated for non-metastatic colorectal cancer. Cochrane Database
to compare tumor dynamic versus conventional end points in randomized Syst Rev 2016;11:CD002200. Available at:
phase II trials. J Clin Oncol 2015;33:36-41. Available at: https://www.ncbi.nlm.nih.gov/pubmed/27884041.
http://www.ncbi.nlm.nih.gov/pubmed/25349295.
691. Mokhles S, Macbeth F, Farewell V, et al. Meta-analysis of colorectal
684. Sargent D, Sobrero A, Grothey A, et al. Evidence for cure by adjuvant cancer follow-up after potentially curative resection. Br J Surg
therapy in colon cancer: observations based on individual patient data 2016;103:1259-1268. Available at:
from 20,898 patients on 18 randomized trials. J Clin Oncol 2009;27:872- https://www.ncbi.nlm.nih.gov/pubmed/27488593.
877. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19124803.
692. Renehan AG, Egger M, Saunders MP, O'Dwyer ST. Impact on
685. Seo SI, Lim SB, Yoon YS, et al. Comparison of recurrence patterns survival of intensive follow up after curative resection for colorectal cancer:
between ≤5 years and >5 years after curative operations in colorectal systematic review and meta-analysis of randomised trials. BMJ
cancer patients. J Surg Oncol 2013;108:9-13. Available at: 2002;324:813-813. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/23754582. http://www.ncbi.nlm.nih.gov/pubmed/11934773.

686. Pietra N, Sarli L, Costi R, et al. Role of follow-up in management of 693. Pita-Fernandez S, Alhayek-Ai M, Gonzalez-Martin C, et al. Intensive
local recurrences of colorectal cancer: a prospective, randomized study. follow-up strategies improve outcomes in nonmetastatic colorectal cancer
patients after curative surgery: a systematic review and meta-analysis.

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Ann Oncol 2015;26:644-656. Available at: 701. Lepage C, Phelip JM, Cany L, et al. Effect of 5 years of imaging and
http://www.ncbi.nlm.nih.gov/pubmed/25411419. CEA follow-up to detect recurrence of colorectal cancer (CRC) -
PRODIGE 13 a FFCD phase III trial [abstract]. Annals of Oncology
694. Guyot F, Faivre J, Manfredi S, et al. Time trends in the treatment and 2020;31:S410. Available at: https://doi.org/10.1016/j.annonc.2020.08.509.
survival of recurrences from colorectal cancer. Ann Oncol 2005;16:756-
761. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15790673. 702. Butte JM, Gonen M, Allen PJ, et al. Recurrence after partial
hepatectomy for metastatic colorectal cancer: potentially curative role of
695. Primrose JN, Perera R, Gray A, et al. Effect of 3 to 5 years of salvage repeat resection. Ann Surg Oncol 2015;22:2761-2771. Available
scheduled cea and ct follow-up to detect recurrence of colorectal cancer: at: http://www.ncbi.nlm.nih.gov/pubmed/25572686.
The facs randomized clinical trial. JAMA 2014;311:263-270. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24430319. 703. Kahi CJ, Boland CR, Dominitz JA, et al. Colonoscopy surveillance
after colorectal cancer resection: recommendations of the US Multi-
696. Wille-Jorgensen P, Syk I, Smedh K, et al. Effect of More vs Less Society Task Force on Colorectal Cancer. Gastroenterology
Frequent Follow-up Testing on Overall and Colorectal Cancer-Specific 2016;150:758-768 e711. Available at:
Mortality in Patients With Stage II or III Colorectal Cancer: The COLOFOL https://www.ncbi.nlm.nih.gov/pubmed/26892199.
Randomized Clinical Trial. Jama 2018;319:2095-2103. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/29800179. 704. Green RJ, Metlay JP, Propert K, et al. Surveillance for second
primary colorectal cancer after adjuvant chemotherapy: an analysis of
697. Verberne CJ, Zhan Z, van den Heuvel E, et al. Intensified follow-up in Intergroup 0089. Ann Intern Med 2002;136:261-269. Available at:
colorectal cancer patients using frequent Carcino-Embryonic Antigen http://www.ncbi.nlm.nih.gov/pubmed/11848723.
(CEA) measurements and CEA-triggered imaging: results of the
randomized "CEAwatch" trial. Eur J Surg Oncol 2015;41:1188-1196. 705. Martin LA, Gross ME, Mone MC, et al. Routine endoscopic
Available at: http://www.ncbi.nlm.nih.gov/pubmed/26184850. surveillance for local recurrence of rectal cancer is futile. Am J Surg
2015;210:996-1002. Available at:
698. Verberne CJ, Zhan Z, van den Heuvel ER, et al. Survival analysis of http://www.ncbi.nlm.nih.gov/pubmed/26453291.
the CEAwatch multicentre clustered randomized trial. Br J Surg
2017;104:1069-1077. Available at: 706. Locker GY, Hamilton S, Harris J, et al. ASCO 2006 update of
https://www.ncbi.nlm.nih.gov/pubmed/28376235. recommendations for the use of tumor markers in gastrointestinal cancer.
J Clin Oncol 2006;24:5313-5327. Available at:
699. Rosati G, Ambrosini G, Barni S, et al. A randomized trial of intensive http://www.ncbi.nlm.nih.gov/pubmed/17060676.
versus minimal surveillance of patients with resected Dukes B2-C
colorectal carcinoma. Ann Oncol 2016;27:274-280. Available at: 707. Macdonald JS. Carcinoembryonic antigen screening: pros and cons.
https://www.ncbi.nlm.nih.gov/pubmed/26578734. Semin Oncol 1999;26:556-560. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/10528904.
700. Lepage C, Phelip JM, Cany L, et al. Effect of 5 years of imaging and
CEA follow-up to detect recurrence of colorectal cancer: The FFCD 708. Pfister DG, Benson AB, 3rd, Somerfield MR. Clinical practice.
PRODIGE 13 randomised phase III trial. Dig Liver Dis 2015;47:529-531. Surveillance strategies after curative treatment of colorectal cancer. N
Available at: http://www.ncbi.nlm.nih.gov/pubmed/25933809. Engl J Med 2004;350:2375-2382. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/15175439.

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Rectal Cancer

709. Hyder O, Dodson RM, Mayo SC, et al. Post-treatment surveillance of 716. Nicholson BD, Shinkins B, Mant D. Blood measurement of
patients with colorectal cancer with surgically treated liver metastases. carcinoembryonic antigen level for detecting recurrence of colorectal
Surgery 2013;154:256-265. Available at: cancer. JAMA 2016;316:1310-1311. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/23889953. https://www.ncbi.nlm.nih.gov/pubmed/27673308.

710. Patel K, Hadar N, Lee J, et al. The lack of evidence for PET or 717. Nicholson BD, Shinkins B, Pathiraja I, et al. Blood CEA levels for
PET/CT surveillance of patients with treated lymphoma, colorectal cancer, detecting recurrent colorectal cancer. Cochrane Database Syst Rev
and head and neck cancer: a systematic review. J Nucl Med 2015:CD011134. Available at:
2013;54:1518-1527. Available at: http://www.ncbi.nlm.nih.gov/pubmed/26661580.
http://www.ncbi.nlm.nih.gov/pubmed/23776200.
718. Lu YY, Chen JH, Chien CR, et al. Use of FDG-PET or PET/CT to
711. Meyerhardt JA, Mangu PB, Flynn PJ, et al. Follow-up care, detect recurrent colorectal cancer in patients with elevated CEA: a
surveillance protocol, and secondary prevention measures for survivors of systematic review and meta-analysis. Int J Colorectal Dis 2013;28:1039-
colorectal cancer: american society of clinical oncology clinical practice 1047. Available at: http://www.ncbi.nlm.nih.gov/pubmed/23407908.
guideline endorsement. J Clin Oncol 2013;31:4465-4470. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24220554. 719. Khan K, Athauda A, Aitken K, et al. Survival outcomes in
asymptomatic patients with normal conventional imaging but raised
712. Follow-up Care, Surveillance Protocols and Secondary Prevention carcinoembryonic antigen levels in colorectal cancer following positron
Measures for Survivors of Colorectal Cancer. Cancer Care Ontario; 2021. emission tomography-computed tomography imaging. Oncologist
Available at: https://www.cancercareontario.ca/en/guidelines-advice/types- 2016;21:1502-1508. Available at:
of-cancer/256. Accessed September 30, 2022. https://www.ncbi.nlm.nih.gov/pubmed/27742904.

713. Sargent DJ, Wieand HS, Haller DG, et al. Disease-free survival 720. Martin EW, Minton JP, Carey LC. CEA-directed second-look surgery
versus overall survival as a primary end point for adjuvant colon cancer in the asymptomatic patient after primary resection of colorectal
studies: individual patient data from 20,898 patients on 18 randomized carcinoma. Ann Surg 1985;202:310-317. Available at:
trials. J Clin Oncol 2005;23:8664-8670. Available at: http://www.ncbi.nlm.nih.gov/pubmed/4037904.
http://www.ncbi.nlm.nih.gov/pubmed/16260700.
721. Yu TK, Bhosale PR, Crane CH, et al. Patterns of locoregional
714. Steele SR, Chang GJ, Hendren S, et al. Practice guideline for the recurrence after surgery and radiotherapy or chemoradiation for rectal
surveillance of patients after curative treatment of colon and rectal cancer. cancer. Int J Radiat Oncol Biol Phys 2008;71:1175-1180. Available at:
Dis Colon Rectum 2015;58:713-725. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18207667.
http://www.ncbi.nlm.nih.gov/pubmed/26163950.
722. Dresen RC, Gosens MJ, Martijn H, et al. Radical resection after
715. Litvka A, Cercek A, Segal N, et al. False-positive elevations of IORT-containing multimodality treatment is the most important determinant
carcinoembryonic antigen in patients with a history of resected colorectal for outcome in patients treated for locally recurrent rectal cancer. Ann Surg
cancer. J Natl Compr Canc Netw 2014;12:907-913. Available at: Oncol 2008;15:1937-1947. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24925201. http://www.ncbi.nlm.nih.gov/pubmed/18389321.

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NCCN Guidelines Version 4.2024

Rectal Cancer

723. Kuehne J, Kleisli T, Biernacki P, et al. Use of high-dose-rate cancer: A meta-analysis and systematic review. Radiother Oncol
brachytherapy in the management of locally recurrent rectal cancer. Dis 2019;140:10-19. Available at:
Colon Rectum 2003;46:895-899. Available at: https://www.ncbi.nlm.nih.gov/pubmed/31176204.
http://www.ncbi.nlm.nih.gov/pubmed/12847362.
731. Hewitt M, Greenfield S, Stovall E. From Cancer Patient to Cancer
724. Wang JJ, Yuan HS, Li JN, et al. CT-guided radioactive seed Survivor: Lost in Transition. 2006. Available at:
implantation for recurrent rectal carcinoma after multiple therapy. Med http://www.nap.edu/openbook.php?isbn=0309095956.
Oncol 2010;27:421-429. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/19415534. 732. El-Shami K, Oeffinger KC, Erb NL, et al. American Cancer Society
Colorectal Cancer Survivorship Care Guidelines. CA Cancer J Clin
725. Hoffman JP, Riley L, Carp NZ, Litwin S. Isolated locally recurrent 2015;65:428-455. Available at:
rectal cancer: a review of incidence, presentation, and management. http://www.ncbi.nlm.nih.gov/pubmed/26348643.
Semin Oncol 1993;20:506-519. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/8211198. 733. Desnoo L, Faithfull S. A qualitative study of anterior resection
syndrome: the experiences of cancer survivors who have undergone
726. Lowy AM, Rich TA, Skibber JM, et al. Preoperative infusional resection surgery. Eur J Cancer Care (Engl) 2006;15:244-251. Available
chemoradiation, selective intraoperative radiation, and resection for locally at: http://www.ncbi.nlm.nih.gov/pubmed/16882120.
advanced pelvic recurrence of colorectal adenocarcinoma. Ann Surg
1996;223:177-185. Available at: 734. Downing A, Morris EJ, Richards M, et al. Health-related quality of life
http://www.ncbi.nlm.nih.gov/pubmed/8597512. after colorectal cancer in England: a patient-reported outcomes study of
individuals 12 to 36 months after diagnosis. J Clin Oncol 2015;33:616-624.
727. Das P, Delclos ME, Skibber JM, et al. Hyperfractionated accelerated Available at: http://www.ncbi.nlm.nih.gov/pubmed/25559806.
radiotherapy for rectal cancer in patients with prior pelvic irradiation. Int J
Radiat Oncol Biol Phys 2010;77:60-65. Available at: 735. Gami B, Harrington K, Blake P, et al. How patients manage
http://www.ncbi.nlm.nih.gov/pubmed/19695792. gastrointestinal symptoms after pelvic radiotherapy. Aliment Pharmacol
Ther 2003;18:987-994. Available at:
728. Guren MG, Undseth C, Rekstad BL, et al. Reirradiation of locally http://www.ncbi.nlm.nih.gov/pubmed/14616164.
recurrent rectal cancer: a systematic review. Radiother Oncol
2014;113:151-157. Available at: 736. McGough C, Baldwin C, Frost G, Andreyev HJ. Role of nutritional
http://www.ncbi.nlm.nih.gov/pubmed/25613395. intervention in patients treated with radiotherapy for pelvic malignancy. Br
J Cancer 2004;90:2278-2287. Available at:
729. Valentini V, Morganti AG, Gambacorta MA, et al. Preoperative http://www.ncbi.nlm.nih.gov/pubmed/15162154.
hyperfractionated chemoradiation for locally recurrent rectal cancer in
patients previously irradiated to the pelvis: A multicentric phase II study. 737. Schneider EC, Malin JL, Kahn KL, et al. Surviving colorectal cancer :
Int J Radiat Oncol Biol Phys 2006;64:1129-1139. Available at: patient-reported symptoms 4 years after diagnosis. Cancer
http://www.ncbi.nlm.nih.gov/pubmed/16414206. 2007;110:2075-2082. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/17849466.
730. Lee J, Kim CY, Koom WS, Rim CH. Practical effectiveness of re-
irradiation with or without surgery for locoregional recurrence of rectal

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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NCCN Guidelines Version 4.2024

Rectal Cancer

738. Sprangers MA, Taal BG, Aaronson NK, te Velde A. Quality of life in 746. Vardy JL, Dhillon HM, Pond GR, et al. Cognitive function in patients
colorectal cancer. Stoma vs. nonstoma patients. Dis Colon Rectum with colorectal cancer who do and do not receive chemotherapy: a
1995;38:361-369. Available at: prospective, longitudinal, controlled study. J Clin Oncol 2015;33:4085-
http://www.ncbi.nlm.nih.gov/pubmed/7720441. 4092. Available at: https://www.ncbi.nlm.nih.gov/pubmed/26527785.

739. Baxter NN, Habermann EB, Tepper JE, et al. Risk of pelvic fractures 747. Wright P, Downing A, Morris EJ, et al. Identifying social distress: a
in older women following pelvic irradiation. JAMA 2005;294:2587-2593. cross-sectional survey of social outcomes 12 to 36 months after colorectal
Available at: http://www.ncbi.nlm.nih.gov/pubmed/16304072. cancer diagnosis. J Clin Oncol 2015;33:3423-3430. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/26282636.
740. Lange MM, Maas CP, Marijnen CA, et al. Urinary dysfunction after
rectal cancer treatment is mainly caused by surgery. Br J Surg 748. Denlinger CS, Barsevick AM. The challenges of colorectal cancer
2008;95:1020-1028. Available at: survivorship. J Natl Compr Canc Netw 2009;7:883-893. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/18563786. http://www.ncbi.nlm.nih.gov/pubmed/19755048.

741. Lange MM, Marijnen CA, Maas CP, et al. Risk factors for sexual 749. Faul LA, Shibata D, Townsend I, Jacobsen PB. Improving
dysfunction after rectal cancer treatment. Eur J Cancer 2009;45:1578- survivorship care for patients with colorectal cancer. Cancer Control
1588. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19147343. 2010;17:35-43. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/20010517.
742. Jansen L, Herrmann A, Stegmaier C, et al. Health-related quality of
life during the 10 years after diagnosis of colorectal cancer: a population- 750. Meyerhardt JA, Heseltine D, Niedzwiecki D, et al. Impact of physical
based study. J Clin Oncol 2011;29:3263-3269. Available at: activity on cancer recurrence and survival in patients with stage III colon
http://www.ncbi.nlm.nih.gov/pubmed/21768465. cancer: findings from CALGB 89803. J Clin Oncol 2006;24:3535-3541.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/16822843.
743. Lynch BM, Steginga SK, Hawkes AL, et al. Describing and predicting
psychological distress after colorectal cancer. Cancer 2008;112:1363- 751. Meyerhardt JA, Giovannucci EL, Ogino S, et al. Physical activity and
1370. Available at: https://www.ncbi.nlm.nih.gov/pubmed/18318044. male colorectal cancer survival. Arch Intern Med 2009;169:2102-2108.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/20008694.
744. Mols F, Beijers T, Lemmens V, et al. Chemotherapy-induced
neuropathy and its association with quality of life among 2- to 11-year 752. Campbell PT, Patel AV, Newton CC, et al. Associations of
colorectal cancer survivors: results from the population-based PROFILES recreational physical activity and leisure time spent sitting with colorectal
registry. J Clin Oncol 2013;31:2699-2707. Available at: cancer survival. J Clin Oncol 2013;31:876-885. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/23775951. http://www.ncbi.nlm.nih.gov/pubmed/23341510.

745. Thong MS, Mols F, Wang XS, et al. Quantifying fatigue in (long-term) 753. Kuiper JG, Phipps AI, Neuhouser ML, et al. Recreational physical
colorectal cancer survivors: a study from the population-based patient activity, body mass index, and survival in women with colorectal cancer.
reported outcomes following initial treatment and long term evaluation of Cancer Causes Control 2012;23:1939-1948. Available at:
survivorship registry. Eur J Cancer 2013;49:1957-1966. Available at: http://www.ncbi.nlm.nih.gov/pubmed/23053793.
https://www.ncbi.nlm.nih.gov/pubmed/23453750.

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Rectal Cancer

754. Arem H, Pfeiffer RM, Engels EA, et al. Pre- and postdiagnosis prospective cohort studies. PLoS One 2015;10:e0120706. Available at:
physical activity, television viewing, and mortality among patients with http://www.ncbi.nlm.nih.gov/pubmed/25811460.
colorectal cancer in the National Institutes of Health-AARP Diet and Health
Study. J Clin Oncol 2015;33:180-188. Available at: 762. Cespedes Feliciano EM, Kroenke CH, Meyerhardt JA, et al.
http://www.ncbi.nlm.nih.gov/pubmed/25488967. Metabolic dysfunction, obesity, and survival among patients with early-
stage colorectal cancer. J Clin Oncol 2016. Available at:
755. Je Y, Jeon JY, Giovannucci EL, Meyerhardt JA. Association between https://www.ncbi.nlm.nih.gov/pubmed/27601537.
physical activity and mortality in colorectal cancer: A meta-analysis of
prospective cohort studies. Int J Cancer 2013;133:1905-1913. Available 763. Daniel CR, Shu X, Ye Y, et al. Severe obesity prior to diagnosis limits
at: http://www.ncbi.nlm.nih.gov/pubmed/23580314. survival in colorectal cancer patients evaluated at a large cancer centre. Br
J Cancer 2016;114:103-109. Available at:
756. Schmid D, Leitzmann MF. Association between physical activity and https://www.ncbi.nlm.nih.gov/pubmed/26679375.
mortality among breast cancer and colorectal cancer survivors: a
systematic review and meta-analysis. Ann Oncol 2014;25:1293-1311. 764. Doleman B, Mills KT, Lim S, et al. Body mass index and colorectal
Available at: http://www.ncbi.nlm.nih.gov/pubmed/24644304. cancer prognosis: a systematic review and meta-analysis. Tech
Coloproctol 2016;20:517-535. Available at:
757. Wu W, Guo F, Ye J, et al. Pre- and post-diagnosis physical activity is https://www.ncbi.nlm.nih.gov/pubmed/27343117.
associated with survival benefits of colorectal cancer patients: a
systematic review and meta-analysis. Oncotarget 2016;7:52095-52103. 765. Laake I, Larsen IK, Selmer R, et al. Pre-diagnostic body mass index
Available at: http://www.ncbi.nlm.nih.gov/pubmed/27437765. and weight change in relation to colorectal cancer survival among incident
cases from a population-based cohort study. BMC Cancer 2016;16:402.
758. Dignam JJ, Polite BN, Yothers G, et al. Body mass index and Available at: https://www.ncbi.nlm.nih.gov/pubmed/27387027.
outcomes in patients who receive adjuvant chemotherapy for colon
cancer. J Natl Cancer Inst 2006;98:1647-1654. Available at: 766. Renfro LA, Loupakis F, Adams RA, et al. Body mass index is
http://www.ncbi.nlm.nih.gov/pubmed/17105987. prognostic in metastatic colorectal cancer: pooled analysis of patients from
first-line clinical trials in the ARCAD database. J Clin Oncol 2016;34:144-
759. Sinicrope FA, Foster NR, Yothers G, et al. Body mass index at 150. Available at: http://www.ncbi.nlm.nih.gov/pubmed/26503203.
diagnosis and survival among colon cancer patients enrolled in clinical
trials of adjuvant chemotherapy. Cancer 2013;119:1528-1536. Available 767. Kroenke CH, Neugebauer R, Meyerhardt J, et al. Analysis of body
at: http://www.ncbi.nlm.nih.gov/pubmed/23310947. mass index and mortality in patients with colorectal cancer using causal
diagrams. JAMA Oncol 2016;2:1137-1145. Available at:
760. Campbell PT, Newton CC, Dehal AN, et al. Impact of body mass https://www.ncbi.nlm.nih.gov/pubmed/27196302.
index on survival after colorectal cancer diagnosis: the Cancer Prevention
Study-II Nutrition Cohort. J Clin Oncol 2012;30:42-52. Available at: 768. Renehan AG, Sperrin M. The obesity paradox and mortality after
http://www.ncbi.nlm.nih.gov/pubmed/22124093. colorectal cancer: a causal conundrum. JAMA Oncol 2016;2:1127-1129.
Available at: https://www.ncbi.nlm.nih.gov/pubmed/27195485.
761. Lee J, Meyerhardt JA, Giovannucci E, Jeon JY. Association between
body mass index and prognosis of colorectal cancer: a meta-analysis of 769. Meyerhardt JA, Niedzwiecki D, Hollis D, et al. Association of dietary
patterns with cancer recurrence and survival in patients with stage III colon

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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Rectal Cancer

cancer. JAMA 2007;298:754-764. Available at: 777. Cardwell CR, Hicks BM, Hughes C, Murray LJ. Statin use after
http://www.ncbi.nlm.nih.gov/pubmed/17699009. colorectal cancer diagnosis and survival: a population-based cohort study.
J Clin Oncol 2014;32:3177-3183. Available at:
770. Meyerhardt JA, Sato K, Niedzwiecki D, et al. Dietary glycemic load http://www.ncbi.nlm.nih.gov/pubmed/25092779.
and cancer recurrence and survival in patients with stage III colon cancer:
findings from CALGB 89803. J Natl Cancer Inst 2012;104:1702-1711. 778. Bains SJ, Mahic M, Myklebust TA, et al. Aspirin as secondary
Available at: http://www.ncbi.nlm.nih.gov/pubmed/23136358. prevention in patients with colorectal cancer: an unselected population-
based study. J Clin Oncol 2016;34:2501-2508. Available at:
771. Fuchs MA, Sato K, Niedzwiecki D, et al. Sugar-sweetened beverage http://www.ncbi.nlm.nih.gov/pubmed/27247217.
intake and cancer recurrence and survival in CALGB 89803 (Alliance).
PLoS One 2014;9:e99816. Available at: 779. Bastiaannet E, Sampieri K, Dekkers OM, et al. Use of aspirin
http://www.ncbi.nlm.nih.gov/pubmed/24937507. postdiagnosis improves survival for colon cancer patients. Br J Cancer
2012;106:1564-1570. Available at:
772. Kushi LH, Byers T, Doyle C, et al. American Cancer Society http://www.ncbi.nlm.nih.gov/pubmed/22454078.
Guidelines on Nutrition and Physical Activity for cancer prevention:
reducing the risk of cancer with healthy food choices and physical activity. 780. Chan AT, Ogino S, Fuchs CS. Aspirin use and survival after
CA Cancer J Clin 2006;56:254-281; quiz 313-254. Available at: diagnosis of colorectal cancer. JAMA 2009;302:649-658. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/17005596. http://www.ncbi.nlm.nih.gov/pubmed/19671906.

773. Hawkes AL, Chambers SK, Pakenham KI, et al. Effects of a 781. Goh CH, Leong WQ, Chew MH, et al. Post-operative aspirin use and
telephone-delivered multiple health behavior change intervention colorectal cancer-specific survival in patients with stage I-III colorectal
(CanChange) on health and behavioral outcomes in survivors of colorectal cancer. Anticancer Res 2014;34:7407-7414. Available at:
cancer: a randomized controlled trial. J Clin Oncol 2013;31:2313-2321. http://www.ncbi.nlm.nih.gov/pubmed/25503181.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/23690410.
782. Li P, Wu H, Zhang H, et al. Aspirin use after diagnosis but not
774. Rock CL, Doyle C, Demark-Wahnefried W, et al. Nutrition and prediagnosis improves established colorectal cancer survival: a meta-
physical activity guidelines for cancer survivors. CA Cancer J Clin analysis. Gut 2015;64:1419-1425. Available at:
2012;62:242-274. Available at: http://www.ncbi.nlm.nih.gov/pubmed/25239119.
http://www.ncbi.nlm.nih.gov/pubmed/22539238.
783. McCowan C, Munro AJ, Donnan PT, Steele RJ. Use of aspirin post-
775. Sun V, Grant M, Wendel CS, et al. Dietary and behavioral diagnosis in a cohort of patients with colorectal cancer and its association
adjustments to manage bowel dysfunction after surgery in long-term with all-cause and colorectal cancer specific mortality. Eur J Cancer
colorectal cancer survivors. Ann Surg Oncol 2015;22:4317-4324. Available 2013;49:1049-1057. Available at:
at: https://www.ncbi.nlm.nih.gov/pubmed/26159443. http://www.ncbi.nlm.nih.gov/pubmed/23182687.

776. Cai H, Zhang G, Wang Z, et al. Relationship between the use of 784. Ng K, Meyerhardt JA, Chan AT, et al. Aspirin and COX-2 inhibitor use
statins and patient survival in colorectal cancer: a systematic review and in patients with stage III colon cancer. J Natl Cancer Inst 2015;107:345.
meta-analysis. PLoS One 2015;10:e0126944. Available at: Available at: http://www.ncbi.nlm.nih.gov/pubmed/25432409.
http://www.ncbi.nlm.nih.gov/pubmed/26030771.

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Rectal Cancer

785. Domingo E, Church DN, Sieber O, et al. Evaluation of PIK3CA Preventive Services Task Force. Ann Intern Med 2016;164:826-835.
mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug Available at: http://www.ncbi.nlm.nih.gov/pubmed/27064261.
therapy in colorectal cancer. J Clin Oncol 2013;31:4297-4305. Available
at: http://www.ncbi.nlm.nih.gov/pubmed/24062397.

786. Elwood PC, Morgan G, Pickering JE, et al. Aspirin in the treatment of
cancer: reductions in metastatic spread and in mortality: a systematic
review and meta-analyses of published studies. PLoS One
2016;11:e0152402. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/27096951.

787. Liao X, Lochhead P, Nishihara R, et al. Aspirin use, tumor PIK3CA

mutation, and colorectal-cancer survival. N Engl J Med 2012;367:1596-
1606. Available at: http://www.ncbi.nlm.nih.gov/pubmed/23094721.

788. Nan H, Hutter CM, Lin Y, et al. Association of aspirin and NSAID use
with risk of colorectal cancer according to genetic variants. JAMA
2015;313:1133-1142. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/25781442.

789. Paleari L, Puntoni M, Clavarezza M, et al. PIK3CA mutation, aspirin

use after diagnosis and survival of colorectal cancer. a systematic review
and meta-analysis of epidemiological studies. Clin Oncol (R Coll Radiol)
2016;28:317-326. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/26712086.

790. Reimers MS, Bastiaannet E, Langley RE, et al. Expression of HLA

class I antigen, aspirin use, and survival after a diagnosis of colon cancer.
JAMA Intern Med 2014;174:732-739. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/24687028.

791. Dulai PS, Singh S, Marquez E, et al. Chemoprevention of colorectal

cancer in individuals with previous colorectal neoplasia: systematic review
and network meta-analysis. Bmj 2016;355:i6188. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/27919915.

792. Whitlock EP, Burda BU, Williams SB, et al. Bleeding risks with aspirin
use for primary prevention in adults: a systematic review for the U.S.

Version 4.2024 © 2024 National Comprehensive Cancer Network© (NCCN© ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN.
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