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Antiarrhythmics

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Nesrin M.Ali
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34 views5 pages

Antiarrhythmics

Uploaded by

Nesrin M.Ali
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Screening and Bioassay of

Antiarrhythmics
Dr. Ahmed Goda, Ph.D.
Associate Professor
Department of Pharmacology and Toxicology
Faculty of Pharmacy, Tanta University
Screening of antiarrhythmics
(ACH+hypokalemia) Epinephrine-
Electrical stimulation-induced
Method  electrical stim.- induced
arrhythmia
induced arrhythmia arrhythmia
In vivo
Setting In vitro In vitro
(under anesthesia??)
Animal
Rabbit, Guinea Pig Rabbit Dogs
species
Isolated
Auricle Atrium
organ
PSS Ringer-Lock Modified Ringer
ACH+hypokalemia
Stimulus Electrical Epinephrine (IV)
electrical stimulus
Determine the maximal rate of
elect. stim. that results in non-
Assessed responsiveness “refract. period” Arrhythmia
ECG monitoring
before & after TTT suppression by TTT
parameter
↑potency↓ max. elect. stim. rate (↑potency↓time)
(Antiarrhythmics ↑ action potential
duration “↑refractory period”)

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