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CLASS – XII (AKUEB)
     BIOLOGY
    (ZOOLOGY)
     TEACHER
MS. MISBAH ASHFAQ
        3
CONTENTS:ZOOLOGY         (XII)
  Chapter # 15: HOMEOSTASIS
    Chapter # 16: SUPPORT &
           MOVEMENT
  Chapter#17: COORDINATION
         AND CONTROL
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      ZOOLOGY PRACTICAL               (15 Marks)
                        CONTENTS
Portfolio                              (3 Marks)
 Stage 1------------- Spotting         (4 Marks)
Task 1 and 2
Identify the given slides/specimens
 Stage 2------------- Slide Prep. (3 Marks)
Task 3 and 4
Stage 3----------                        (5 Marks)
Task 5,6,7 and 8
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   SLO # 15.1.1
Define homeostasis
   SLO # 15.1.2
        .
  Significance of
   homeostasis
           HOMEOSTASIS
◍   HOMEOSTASIS is the maintenance of a
    constant internal environment.
             33
Q:Which of these correct statements
describes control by negative feedback?
A-An injury to body tissue activates platelets in the blood
and these activated platelets release.
                            46
OSMOCONFORMERS contain urea and
trimethylamine oxide (TMAO) in their
   blood to adjust osmotic balance.
TMAO accumulates in the tissues and
     protects against the protein-
     destabilizing effects of urea.
                 48
   B) OSMOREGULATION BY PRODUCING
               DILUTE URINE:
Fresh water animals like fishes have a
hypertonic body fluids than the
surrounding water. Thus they remove
excess water by passing large quantities
of very dilute urine. During the excretion
process, they lose some essential ions as
well. However this is overcome by actively
absorbing selected ions from outside,
through gills. E.g. Trout
                    49
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OSMOREGULATORY ADAPTATIONS IN FRESH
         WATER ANIMALAS
         Large
                                 Kidney
        volume
                             reabsorbs the
       of diluted
                             salts that are
         urine
                                required
 Actively transport                 Salts are also
   salts from the                     obtained
  outside with the                    from the
 help of special salt                    food
  cells (ionocytes)
                        51
  15.2.3: OSMOREGULATION IN AQUATIC
           (MARINE) ANIMALS:
Marine bony fishes have hypotonic internal
environment so they are liable to lose water.
So in order to conserve water, they constantly
drink water. The salts taken in along with
water are actively excreted by special
excretory cells in the gills. Moreover, the
filtration rate in their kidneys is very low so
small quantity of concentrated urine is
excreted. E.g. Mackerel
                       52
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OSMOREGULATORY ADAPTATIONS IN MARINE
             ANIMALAS
     Small
                               Excess salts are
   amount of
                               removed across
    water in
                             the gill epithelium
     scanty
                              (Na+,Cl- and K+)
      urine
                             and by the kidney
   Some fishes also          (Mg++ and Ca++)
   have special salt
  secreting glands in
  the wall of rectum
    (rectal glands)
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To combat this, freshwater fish have very efficient
kidneys that excrete water quickly. They also
reabsorb salt from their urine before it is ejected
to minimize losses and actively take salt from
their environment using special cells in the gills.
             58
a) WATER PROOF EXTERNAL COVERINGS:
To prevent water loss through external surfaces,
vertebrate like reptiles, birds and mammals have
water proof keratinized epidermis. Similarly the
insects have developed an external water-proof
layer called CUTICLE.
                        59
b) STORING AND EXCRETION OF SOLID WASTES:
Reptiles, birds and insects excrete uric acid as nitrogenous
waste, which is insoluble in water. It is stored temporarily
in cloaca where water is reabsorbed from it before its
removal from the body in semi-fluid form.
                              60
c) USE OF METABOLIC
WATER:
Some mammals like
camel, kangaroo-rat etc.
make use of water
produced during the
breakdown of body fats.
in animals
           EXCRETION
“Excretion is a process by which
metabolic waste products and toxic
substances are eliminated from the
body of an organism.”
 In vertebrates this is primarily
carried out by the lungs, kidneys
and skin.
                 63
    SLO # 15.5.1
EXCRETORY . PRODUCTS
   IN RELATION TO
       HABITAT
EXCRETORY PRODUCTS IN RELATION TO
            HABITAT
AMMONIA          CREATINIE OR
                TRIMETHYLAMINE
                 OXIDE (TMAO)
UREA
 URIC               HYPOXANTHINE
 ACID
               65
TYPES OF EXCRETORY WASTES IN DIFFERENT ANIMALS
                      66
               AMMONIA
                (NH3)
1- Ammonia is a small gaseous molecule and is
highly soluble in water.
2- It diffuses very rapidly across the plasma
membrane.
3- It is highly toxic because it tends to raise the
pH of body fluids and interferes with membrane
transport functions.
4- Excreting ammonia by an animal is
advantageous because it does not require energy.
                         67
5- Its toxicity is reduced when diluted with large
quantities of water (1 gm of nitrogen, in the form of
ammonia requires 500 ml of water to dissolve it to
nontoxic level). Such plenty of water can only be
afforded by many aquatic organisms (ammonotelic),
particularly those in freshwater.
SYSTEM IN MAN
   EXCRETION
“Excretion is a process
by which metabolic
waste products and
toxic substances are
eliminated from the        ﹡.
body of an organism.”
 In vertebrates this is
primarily carried out by
the lungs, kidneys and
skin.
                           77
    HUMAN
  EXCRETORY
SYSTEM consists of:
1- a pair of kidneys
2- a pair of ureters
3- a urinary bladder
4- the urethra
                   78
The   KIDNEYS      are a
pair of bean-shaped
organs on either side of
your spine, below your
ribs and behind your
belly. Each kidney is
about 4 or 5 inches
long, roughly the size
of a large fist.
The kidneys' job is to
filter your blood.     79
The URETERS          are 25 to 30
cm long tubes connected anteriorly
with kidneys by wide opening
called RENAL PELVIS. Posteriorly
they become narrow and extended
downward to join urinary bladder.
The URINARY BLADDER
is an elastic muscular bag located
in front of the rectum. It stores
urine.
The URETHRA           is the duct
through which urine passes from
the bladder to outside of the body.
                              80
15.4.1:STRUCTURE
AND FUNCTION OF
     KIDNEY
        81
STRUCTURE: kidneys are symmetrical,
bean shaped reddish brown structures.
LOCATION: They located just below
the rib cage, one on each side of the
vertebral column between the 12th
thoracic and 3rd lumber vertebrae.
Kidneys positioned retroperitoneal in
the abdominal cavity. The right kidney
is located slightly below the left kidney
providing space to adjust liver. Left
kidney is slightly larger and closer to
the heart.
SIZE: These are 4-5 inches long almost
size of the fist.
                                 82
OUTER LAYERS OF KIDNEY
           83
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  15.4.2:
STRUCTURE
    OF
 NEPHRON
     88
 Both kidneys are
   consisted of
    millions of
 functional units
called NEPHRONS.
 These nephrons
  are about one
  million in each
kidney and mainly
perform filtration
     of blood.
                     89
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       NEPHRON
is composed of:
1- The RENAL
CORPUSCLE consists
of a tuft
of capillaries called
a GLOMERULUS and
 BOWMAN'S
CAPSULE.
2- The RENAL TUBULE
extends from the
capsule.                93
The tubule has 4 anatomically
and functionally different
parts:
(i)The proximal
convoluted tubule followed
by a straight section
 (ii)The loop of Henle, which
has two parts, the descending
loop of Henle ("descending
loop") and the ascending loop
of Henle ("ascending loop");
(iii)The distal convoluted
tubule and
 (iv)the last part of nephron
the collecting ducts.           94
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    The efferent
 arteriole extended
down and forming a
     network of
  capillaries called
   PERITUBULAR
 CAPILLARIES that
surrounds the both
  PCT and DCT. It
 provides nutrients
 and oxygen to the
    renal cortex.      105
 Peritubular capillaries
   moves downward
   along with loop of
  henle give branches
   which are laterally
  connected with the
capillaries of renal vein
or venule in the region
    of medulla. This
  complex network of
  capillaries over the
  loop of henle called
      VASA RECTA.        106
 15.3.3: FUNCTIONS OF THE KIDNEY
                     113
       REGULATING BLOOD
        WATER POTENTIAL
◍ The water potential of the blood has to be kept
  relatively constant. Drastic changes of water
  potential can cause serious problems. For
  example, if blood plasma becomes too dilute,
  the blood cells and tissue cells will swell
  (because of endosmosis) and burst.
◍ If the blood plasma becomes too concentrated,
  exosmosis will cause the blood cells and tissue
  cells to become dehydrated and shrink.
                        114
                  OSMOREGULATION
The key point for understanding osmoregulation is that all along the length of the nephron tubule, fluid
and solutes are exchanged between the filtrate in the tubule and the blood in the capillaries. This allows
the kidneys to fine-tune the composition of the blood. The solutes and fluids that aren’t reabsorbed into
the blood are excreted as urine.
Body maintain water and electrolytes concentration at a relatively constant level by the mechanism
of osmoregulation.
Keeping your body fluids isotonic to body tissues is known as osmoregulation, and the key regulator of
your blood’s homeostatic set point for osmoregulation is the hypothalamus,
The hypothalamus is located just above the pituitary gland. When sensors in the hypothalamus detect that
the blood has become too concentrated (hypertonic), they signal the pituitary to release the
hormone ADH into the bloodstream. Antidiuretic hormone (ADH) has the
primary role in osmoregulation by controlling the amount of urine formation.
Anti-diuretic hormone (ADH) regulates the level of water reabsorption in the collecting duct.
Because it’s the antidiuretic hormone, ADH has the opposite effect that a diuretic has. ADH acts on the
lower part of the tubule, a part of the nephron tubule called the collecting duct
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DISORDERS OF
URINARY TRACT
      125
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 RENAL
STONES
  OR
 RENAL
CALCULI
          129
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1- KIDNEY STONES OR CALCULI are mainly (about
70%) composed of calcium oxalate or phosphate.
Oxalate is an end product of body metabolism and
is present naturally in the urine . The salt it forms
with calcium has a low solubility. An abnormally
high level of oxalate in urine promotes stone
formation and may be related to a diet containing
food or drinks with a high content of oxalic acid,
for example tomato, spinach, leafy vegetables etc.
About 20% of calculi are termed as infective
stones. Such calculi consist of combination of
calcium, magnesium and ammonium phosphate.
Some stones (about 5%)133are formed by uric acid.
LITHOTRIPSY is a recent method for removing
kidney and ureteral stones. In this procedure
shock waves or ultrasonic waves are used to
break up calculi for removal. Ultrasonic
lithotripsy involves the use of an ultrasonic
probe through a telescopic tube to help break
up the stones.
Shock waves lithotripsy is more advance
method in which shock waves are being
focused on stones from outside the body. After
being broken, the smaller fragments are
passed in urine.        134
         LITHONEPHRITIS
The word lithonephritis refers a
condition in which the kidneys
become inflamed due to the
presence of calculi (i.e., kidney
stones). Calculi can irritate the
cells and tissues of the kidneys,
and this irritation can lead to pain
and inflammation.135
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LITHOTRIPSY
     137
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EXTRACORPO-
    REAL
(OUTSIDE THE
BODY) SHOCK
    WAVE
LITHOTRIPSY
   (ESWL)
               139
PERCUTANEOUS NEPHROLITHOTOMY
           (PCNL)
            140
LAPAROSCOPIC PYELOLITHOTOMY
            141
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               2- KIDNEY/RENAL FAILURE
Kidney failure, also known as end-stage kidney
disease, is a medical condition in which the kidneys are
functioning at less than 15% of normal. There is a
reduction in the ability of the kidneys to filter waste
products from the blood and excrete them in urine, for
osmoregulation and to regulate the blood pressure.
As a consequence the nitrogenous wastes start
accumulating in the blood which leads to the
symptoms such as nausea, vomiting, loss of appetite,
weakness, breathlessness etc.
In severe cases, it leads to coma and death.
Associated complications may include pneumonia,
bleeding in the stomach, high blood pressure etc.
                           143
       CAUSES OF KIDNEY FAILURE
The most common causes are:
•   High blood pressure.
•   Chronic glomerulonephritis (kidney damage)
•   High blood sugar (diabetes)
•   Polycystic kidney disease.
•   Blocked urinary tract.
•   kidney infection.
•   Alcohol abuse(constant heavy drinking)
•   Severe accidents that physically damage the kidney
•   Complications from undergoing major surgery
                             144
                  DIALYSIS
In medicine, dialysis is the procedure of removing excess water,
solutes, and toxins from the blood in people whose kidneys can no
longer perform these functions naturally. This is referred to as
renal replacement therapy.
(i) HEMODIALYSIS
(ii) CONTINUOUS RENAL REPLACEMENT
    THERAPY (CRRT)and
(iii)PERITONEAL DIALYSIS
147
                  PRINCIPLE
Dialysis works on the principles of the diffusion of solutes
and ultrafiltration of fluid across a semi-permeable membrane.
Diffusion is a property of substances in water; substances in water
tend to move from an area of high concentration to an area of low
concentration. Blood flows by one side of a semi-permeable
membrane, and a dialysate, or special dialysis fluid, flows by the
opposite side. A semipermeable membrane is a thin layer of
material that contains holes of various sizes, or pores. Smaller
solutes and fluid pass through the membrane, but the membrane
blocks the passage of larger substances (for example, red blood
cells and large proteins). This replicates the filtering process that
takes place in the kidneys when the blood enters the kidneys and
the larger substances are separated from the smaller ones in
the glomerulus.                     148
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       FEATURES OF A DIALYSIS MACHINE
◍ * The dialysis fluid contains
  the same concentration of
  essential substances as
  healthy blood
◍ *The dialysis fluid
  (dialysate)does not contain
  metabolic waste products
◍ *The tubing in the machine
  is narrow, long and coiled
◍ *The direction of the blood
  flow is opposite to the flow
  of the dialysis fluid
                                        150
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                    AV FISTULA
An AV FISTULA is a connection that's made
between an artery and a vein
for dialysis access. A surgical procedure,
created by a vascular specialist. With an AV
fistula, blood flows from the artery directly
into the vein, increasing the blood pressure
and amount of blood flow through the
vein. The increased flow and pressure
causes the veins to enlarge. The enlarged
veins will be capable of delivering
the amount of blood flow necessary to
provide an adequate hemodialysis
treatment. The fistula usually requires from
8 to 12 weeks for the veins to dilate prior to
initial use.                      152
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       PERITONEAL DIALYSIS
        161
POIKILOTHERMS (COLD BLOODED)
are those animals whose body
temperature changes in
accordance with the fluctuations
of the environmental
temperature.
Examples: All invertebrates,
fishes, amphibian and most
reptiles        162
HOMOIOTHERMS (WARM BLOODED)
are those animals who have
constant body temperature which
is independent of the
environmental temperature.
Examples: Few reptiles, Birds
and Mammals
              163
ECTOTHERM are those animals
who absorb heat energy from
their environment. They have
behavioural means of
thermoregulation.
Example: Lizards basking in
the sun
              164
ENDOTHERMS are those animals
who generate their own heat
energy from their
environment. They have
physiological as well as
behavioural means of
thermoregulation.
Example: Mammals
              165
HETEROTHERMS are those
animals who generate heat of
varying degrees so their body
temperature is kept in a
wider range.
 Example: Bats, Humming
birds etc.
              166
THERMOREGULATION IN
   MAMMALS (MAN)
         167
There are two ways to increase heat
production:
1- SHIVERING THERMOGENESIS
( Heat production by increasing
contraction of muscles
                  ﹡.   through
shivering)
2- NON-SHIVERING THERMOGENESIS
(Heat production due to the action of
certain hormones)
                  168
In some mammals,
thermogenesis
occurs due to a
specialized tissue
called BROWN FAT,
which is found in the﹡ .
neck and between
the shoulders. This is
specialized for rapid
heat production.
                     169
         TEMPERATURE REGULATION
           HEAT PRODUCTION AND HEAT LOSS
171
   TEMPERATURE REGULATION
The HYPOTHALAMUS in the brain monitors
and regulates the body temperature.
The hypothalamus receives information
about temperature changes from two
sources.
(i) Thermoreceptors in the skin which
detects temperature from the environment.
(ii) Thermoreceptors in the hypothalamus
which detect temperature
                    172   of the blood.
 MECHANISMS OF THERMOREGULATION IN COLD
              TEMPERATURE
        1-                    2-
  PHYSIOLOGICAL          BEHAVIOURAL
   MECHANISMS            MECHANISMS
                  ﹡.
        Behavioural mechanisms
      include moving to a warmer
        location, huddling close
           together with other
     individuals; in humans putting
          on additional clothes.
                  176
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MECHANISMS OF THERMOREGULATION IN HOT
            TEMPERATURE
       1-                   2-
 PHYSIOLOGICAL         BEHAVIOURAL
  MECHANISMS           MECHANISMS
                 ﹡.
        Behavioural mechanisms
       include moving to a cooler
     location, in humans putting on
               thin clothes.
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ROLE OF BRAIN In
 TEMPERATURE
       ﹡.
REGULATION
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﹡.
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   👍
Thanks!
 Any questions?
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