Bioenergetic Fundamentals
Inspired by Dr. Ray Peat | Danny Roddy | Georgi Dinkov | Dr. Gilbert Ling
                  *Difficulty digesting ANY food CAN be solved with proper nuance & context
         Carbohydrates                                                   Proteins
         Ideal Range 300+ Grams A Day                           Ideal Range 100-125 Grams A Day
     Pulp-Free Organic Orange Juice                          Milk Without Added Vitamin A/D
  (Not from concentrate, preferably organic or          (A2 for those more sensitive or Camel's milk and
from ripe sweet oranges that you juice yourself          make sure there is no added [fortified] vitamin
   and strain ALL fibers out, but can be store-           D or A. Raw preferred but pasteurized works.
     bought. Potassium modulates insulin.)               Liposomal colostrum to reverse dairy allergy.)
                    Honey                                                Duck/Chicken Eggs
       (Local, Raw, Organic, Unheated.)                      (If sulfur issues consider molybdenum with
                                                                eggs and address dysbiosis in the gut.)
                    Sugar
 (No brown sugar. So long as calcium is high                      Gelatin/Collagen Peptides
   [eggshell/dairy with K2 5-10mg a day])                 (Make some gelatin, add some pulp-free juice
                                                          and let sit overnight, and have gelatin snacks
                 Ripe Fruits
                                                         throughout the day. This is the best amino-acid
(Typically with skins taken off, avoid banana's
                                                          profile really of all the protein sources due to
  in general due to their proclivity in raising
                                                         high glycine/proline and no tryptophan. Go for
                   serotonin.)
                                                             Collagen Peptides if Gelatin is irritating.)
             White Russet Potato
                                                                   Goat/Bovine/Sheep Cheese
  (May spike insulin too much initially. Only eat
                                                          (If digestion is slow keep low or with functional
fresh out of the oven or heat source, do not put
                                                         fibers listed below. The more aged cheeses have
in the refrigerator and reheat later as they turn
                                                                 more histamine content in general.)
into a resistant starch once cooled, which feeds
bacteria in the gut indiscriminately which leads              Meats from beef, bison, cod, sole,
   to dysbiosis and more endotoxin-load. Best            oysters, crab, shrimp, lobster, and lamb.
 eaten without the skins, can add butter, it goes          [avoid chicken/turkey/pork/salmon especially]
 best with a little protein with it such as cheese.)      (You generally want cysteine, methionine, and
                                                             especially tryptophan to be lower as these
                                                           amino acids oppose proper thyroid function
                      Fats                                and increase serotonin. Muscle meat is rich in
         Ideal Range ~ Less Than Carbs                     these amino acids and you can counteract it
                                                         with collagen peptides [Vital Proteins] taken 1-2
              Butter/Ghee/Milk
                                                           scoops with the meat or just prior, or gelatin,
 (Once you reverse any sensitivity to these, this
                                                         and take with dairy or eggshell calcium to keep
          is the ideal saturated fats.)
                                                          calcium to phosphorus ratio in balance cause
                Animal Fat                                 muscle meat is rich in phosphorus but not in
   (From meats to the right preferably from               calcium. And you want calcium to typically be
       species-appropriately fed diets.)                    2:1 or 1:1 ratio of calcium to phosphorus.)
                    Coconut
           (Refined or virigin coconut.)
                                                               Functional Fibers
             Superfoods                                      Organic White Button Mushroom
                                                          (Boil Medium-High for 3 full hours with open-
       Pasture-Raised Bovine Liver                          air ventilation to remove most of the toxic
   (The retinol [Vitamin A] is superior to any                       hydrazine and agaritine.)
       form known to research, as is the
 bioavailable copper which helps proper iron                   Raw Carrots Grated Length-Wise
  metabolism. I no longer recommend dried                    (Add 1-2 tsp organic white vinegar, 1-2tsp
 capsules of liver. Pan-searing it then adding                refined coconut oil, sea salt for a salad.)
 some honey and sea salt with mushrooms is
  very tasty. Get 6-9oz in A WEEK. Your skin                        Boiled Bamboo Shoots
     and immune system will thank you.)                    (Add to a soup. Use canned bamboo shoots.)
                   Oysters
 (The selenium, zinc is critical to balancing the                          AVOID
      copper found in the liver. These two
  superfoods are also critical as you increase                    PUFA's [polyunsaturated fats]
    carbohydrate metabolism so you don't                   (PUFA is linked to damage of the beta cells in
  experience downsides to sugar metabolism                the pancreas, damage to the thyroid. Leads to
     increasing. Use Oyster Extract by Bulk              rapid aging. Avoid ALL vegetable/plant/nut/seed
   Supplements, and add a tsp to one of my                              oils [minus coconut]).
   meals each day. I'd recommend cooking if
                                                           Nuts, Seeds [minus coffee], Soy [minus
             you eat them straight.)
                                                             Natto], Dried Fruit, Unripe Fruit,
                                                           Uncooked Vegetables [minus carrot],
               Organic Coffee
                                                         Legumes, Beans, Grains [minus white rice],
 (When mixed with milk/creamer, and a sugar
                                                          Carrageenan, Guar Gum, Acacia Gum,
  source ONLY. Best taken post-meal to down-
                                                          Most Fermented Foods, Breads/Baked
   regulate iron. Magnesium is high as well.)
                                                         Goods, Corn, HF Corn Syrup, Citric Acid.
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                 Vitamin Fundamentals
     Inspired by Ray Peat | Danny Roddy | Georgi Dinkov | Gilbert Ling | Hans Selye | Albert Szent-Györgyi
       ~ To heal fast, move gently & methodically ~
 Thiamine (Vitamin B1) Thiamine HCL | TTFD tetrahydrofurfuryl disulfide | Supplement
ALL B vitamins are capable of improving carbohydrate metabolism. In my opinion, it's one of
the most important variables when navigating Ray Peat's work. Start with HCL version as it's
   low in bioavailability, and isn't sulfur-bound, so it is less apt to cause bizarre symptoms.
  Most critical ranges are 200-1,200mg a day. And the TTFD version is lower around 100-
      250mg, and usually needs co-factors such as B2/molybdenum/selenium if sulfur
 metabolism isn't ideal. Methylated B-Complex, multi-magnesium, and potassium chloride
     are all important co-factors in minimizing symptoms from high-dose thiamine. This
  substance can entirely alter your mitochondrial health. And can particularly help restore
     vagal nerve tone, improve gut motility, blood pressure regulation, sleep apnea, etc.
              Niacinamide (Vitamin B3) - Beef Liver | NOT Niacin | Supplement
     50-100mg of niacinamide a few times a day for conditions like arthritis and diabetes.
  Nothing more than 2 grams a day in most circumstances. Glucose and niacinamide work
  very closely with each other, and with thyroid hormone, in the maintenance and repair of
 cells and tissues. When one of these energy-producing factors is lacking, the changes in cell
         functions – a sort of pre-inflammatory state – activate corrective processes.
       B-Complex - Beef Liver | Phosphorylated | Methylated | Topical | Supplement
  B2 Riboflavin 5 phosphate | B3 Niacinamide | B4 Choline/Adenine| B5 Pantothenic Acid
   Calcium D-Pantothenate | B6 Pyridoxine HCL/Pyridoxal 5' Phosphate | B7 biotin | B8
Inositol | B9 Folate L-5-Methylfolate/glucosamine salt | B10 PABA Para Amino Benzoic Acid
    | B11 Salicylic acid | B12 methylcobalamin, adenosylcobalamin, hydroxocobalamin.
         Vitamin A (Retinol) - Grass-fed Beef Liver | Rarely Supplement | Topical
       Approx. 6-12oz a week in general of pan-seared beef liver. I no longer recommend
  encapsulated dehydrated beef liver due to retinol oxidation. This is very critical to improve
  carbohydrate metabolism, and always balance this with oysters, as the copper in the liver
          really should be balanced by the bioavailable form of zinc in the oysters.
             Vitamin D3 - Biological Light | Food Sources | Supplement | Topical
     Photobiomodulation therapy (sunlight) is undeniable. Beef liver/Egg Yolk/Goat's Milk. And
 nowadays so is supplemental vitamin D3. I would suggest aiming for approximately 5,000IU
 for most people. This can shift considerably depending on a variety of contexts. Remember
          all fat-soluble vitamins (A,D,E,K) are best taken together, especially K2/D3.
             Vitamin K2 (MK4 Primarily) - Food Sources | Supplement | Topical
  Beef Liver/Egg Yolks/Gouda 13 weeks+, Edam/Maasdam 5 weeks+, Raw Milk Cheese, etc./Natto.
  This substance in my experience is best at 5-10mg (5mg twice a day) at minimum for most
     in MK4 (Thorne Research). In some instances 45mg a day. Top recommendation for
             preventing the likelihood of stroke, atherosclerosis, and osteoporosis.
   Vitamin E (8 types) - Food Sources | Supplement | Topical | Take 4 hours away from K2
       Beef Liver/Palm Oil/Wheat Germ Oil/Grass-Fed Beef. Vitamin E reduces oxidative stress
     significantly. Vitamin E, like progesterone and aspirin, acts within the cellular regulatory
systems, to prevent inflammation and inappropriate excitation. Besides antagonizing some of
 the end effects of the toxic fatty acids, vitamin E inhibits lipolysis, lowering the concentration
 of free fatty acids (the opposite of estrogen’s effect), and it also binds to and inactivates free
       fatty acids. Approximately 0.4mg of alpha-tocopherol per gram of PUFA ought to be
    consumed. The more PUFA you consume the more E you NEED. Grass-fed beef has 4.07
     (ug/g tissue) of alpha-tocopherol than Grain-fed 0.75. In other words, it has 1.3-5.4-fold
      higher vitamin E than grain-fed beef. As with all fat-soluble vitamins, the more fat you
consume, the greater the absorption rate of these you'll experience. I rarely recommend oral
supplementation unless consuming PUFA rich meals or for a medical reason. D-version only,
as DL-versions are synthetic, and this doesn't seem to be a wise one to be taken synthetically.
  If taken orally, Natural Origins Tocomin SupraBio or Allergy Research Group are my current
                    recommendations. Ideal Labs Tocovit as well for transdermal.
         Vitamin C - Food Sources | Food-Sourced Supplement | NOT Ascorbic Acid
     Pulp-Free Orange Juice [not from concentrate]/Raw Beef Liver. Is a major component for
     transforming cholesterol to bile acids, and when deficits occur in the liver you see a
   decrease in proper cholesterol function in the body. Fasting blood glucose, triglycerides,
 total cholesterol, low and high-density (LDL, HDL), glycated hemoglobin HbA(1c), and serum
   insulin all improve around 1 gram of supplemented vitamin C a day. Pure Synergy Pure
   Radiance C is the only product I recommend aside from occasional liposomal use or IV.
                                  Why Pay Attention?
  Often times when recovering from illness in order to restore metabolism you'll need to dig
  deep on micronutrient status, as it impacts mitochondrial function massively. Some people
  will require much higher therapeutic doses of B vitamins in specific forms than others. This
          can literally make the difference in reversing disease at its fundamental level.
*Difficulty metabolizing ANY compound CAN be resolved with proper nuance, patience & context
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                 Origins of Disease 001
 Inspired by Dr. Ray Peat | Danny Roddy | Georgi Dinkov | Dr. Gilbert Ling | Functional Performance Systems
              *Powerful Compounds That Influence Diseased States | Quotes From Dr. Ray Peat
          Iron Overload                                            Nitric Oxide
   "During aging, our tissues tend to store an                 “Nitric oxide is increasingly seen as an
   excess of iron. There is a remarkably close                important factor in nerve degeneration
    association between the amount of iron               (Doherty, 2011). Nitric oxide activates processes
   stored in our tissues and the risk of death              (Obukuro, et al., 2013) that can lead to cell
     from cancer, heart disease, or from all                death. Inhibition on the production of nitric
   causes. This relationship between iron and             oxide protects again various kinds of dementia
  death rate exists even during childhood, but             (Sharma & Sharma, 2013, Sharma & Singh,
   the curve is downward until the age of 12,             2013). Brain trauma cases see a large increase
    and then it rises steadily until death. The              in nitric oxide formation, and blocking its
    shape of this curve, representing the iron             synthesis improves recovery (Huttenmann, et
   burden, is amazingly similar to the curves                       al., 2008); Gahn, et al., 2006).
 representing the rate of death in general, and
   the rate of death from cancer. There is no           “Nitric oxide, a third cultic substance along with
  other relationship in biology that I know of               serotonin and estrogen, is invoked as a
       that has this peculiar shape, with its           normalizer of brain circulation and protector of
 minimum at the age of 12, and its maximum                  nerve cells from peroxidation. Whether a
         in old age at the time of death.                 substance is an antioxidant or pro-oxidant
                                                          depends on its environment, and both nitric
    "An excess of iron, by destroying vitamin E         oxide and estrogen are pro-oxidants, promoters
     and oxidizing the unsaturated fats in red            of lipid peroxidation and other forms of cell
      blood cells, can contribute to hemolytic              damage, under a variety of physiological
  anemia, in which red cells are so fragile that                             situations.”
   they break down too fast. In aging, red cells
  break down faster, and are usually produced
      more slowly, increasing the tendency to             Unopposed Estrogen
  become anemic, but additional iron tends to
       be more dangerous for older people."              “Estrogen and PUFA create insulin resistance,
                                                             and the resulting state of “diabetes” and
                                                               stress de-energizes tissues, with the
               Serotonin                                       mitochondria that are damaged by
                                                           unsaturated fatty acids, nitric oxide, tumor
   "There are people who advocate the use of             necrosis factor (TNT), serotonin, etc., failing to
 tryptophan supplementation or other means                    meet the tissues’ energy needs. Stress,
     to increase serotonin in the tissues as a           endotoxinemia, and increased estrogen tend
 treatment for the fibromyalgia syndrome, but               to activate TNF, which has a role in brain
      the evidence increasingly suggests that             degenerative diseases and osteoporosis and
   excessive serotonin, interfering with muscle            multiple organ failure. Much research has
       mitochondria, is a major factor in the             focussed on a search for a single substance
    development of that syndrome. In 1965,                   that is responsible for the inflammatory
     Hans Selye showed that the injection of                  conditions of Alzheimer’s disease, but
     serotonin caused muscular dystrophy."                inflammation and aging are processes that
                                                            involve many causes and mediators, with
                                                         each individual’s history causing variations in
             Endotoxins                                                     the details.”
   “Bacterial endotoxin increases serotonin                 "All of the unpleasant consequences of
 release from the intestine, and increases its           estrogen excess happen to resemble some of
  synthesis in the brain (Nolan, et al., 2000)          the events of aging. If aging involves the same
 and liver (Bado, 1983). It also stimulates its          processes that are created by estrogen, then
release from platelets, and reduces the lungs’            our knowledge of how to protect ourselves
     ability to destroy it. The formation of                against estrogen can be used to protect
serotonin in the intestine is also stimulated by            ourselves against aging. Estrogen steals
the lactate, propionate, and butyrate that are           oxygen from mitochondria, shifting patterns
   formed by bacteria fermenting fiber and                         of growth and adaptation."
    starch, but these bacteria also produce
   endotoxin. The inflammation-producing
  effects of lactate, serotonin, and endotoxin              Lactate/Lactic Acid
   are overlapping, additive, and sometimes
synergistic, along with histamine, nitric oxide,           "The presence of lactic acid in our tissues is
         bradykinin, and the cytokines.”                  very meaningful, but it is normally treated as
                                                           only an indicator, rather than as a cause, of
   “The maladaptive sequence, starting from                biological problems. Its presence in rosacea,
    stress or hypothyroidism, would typically             arthritis, heart disease, diabetes, neurological
  involve increased absorption of endotoxin,                diseases and cancer has been recognized,
  leading to interference with mitochondrial                  and recently it is being recognized that
       respiration, a shift to fat oxidation,             suppressing it can be curative, after fifty years
   inflammation, and the increase of a wide                of denial. The influence of politics on science
    range of stress hormones. Each of these                 is so profound that neither historians nor
  happens to interfere with the production of               scientists often care to consider it honestly
     progesterone, leading to increased LH.”                               and in depth."
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