nystatin (Rx) - Mycostatin, Nilstat, more..
Class: Antifungals, Other;
Antifungals, Systemic
Dosing & Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Dosing & Uses
Adult
Dosing Forms & Strengths
oral powder
100,000units/g
oral suspension
100,000units/mL
oral tablet
500,000units
capsule
500,000units
1,000,000units
Oropharyngeal Candidiasis
Oral suspension: 400,000-600,000 units PO q6hr; swish in mouth several minutes and then
swallow
Intestinal Candidiasis
Oral tablets: 500,000-1,000,000 units q8hr
Powder: 1/8 to 1/4 teaspoonful in 1/2 cup of water (500,000-1,000,000 units) PO q8hr
Invasive Fungal Infections (Orphan)
Liposomal nystatin: Treatment of invasive fungal infections
Orphan indication sponsor
The University of Texas, M.D. Anderson Cancer Center, Unit 038; Houston, TX
77030
Administration
Retain suspension in mouth as long as possible before swallowing
Pediatric
Oropharyngeal Candidiasis
Premature infants
100,000 units PO q6hr; paint suspension into recesses of the mouth
Infants
200,000 units PO q6hr (100,000 units in each side of mouth); paint suspension into
recesses of the mouth
Children
Oral suspension: 400,000-600,000 units PO q6hr; swish in mouth several minutes and
then swallow
Intestinal Candidiasis
Oral tablets: 500,000 units-1,000,000 units q8hr
Powder: 1/8 to 1/4 teaspoonful in 1/2 cup of water (500,000-1,000,000 units) PO q8hr
Drug Interactions
Interaction Checker
nystatin and
Type a dru
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Contraindicated (1)
allogeneic cultured keratinocytes/fibroblasts in bovine collagen
nystatin decreases effects of allogeneic cultured keratinocytes/fibroblasts in bovine
collagen by Other (see comment). Never use combination. Comment: Exposure to
topical antibiotics has been shown to degrade Gintuit; if exposed, irrigate the wound
thoroughly with saline and allow a suitable wash-out period to elapse before applying
Gintuit.
Serious - Use Alternative (0)
Significant - Monitor Closely (0)
Minor (0)
Adverse Effects
Frequency not defined
Diarrhea
Nausea
Stomach pain
Vomiting
Contact dermatitis
Stevens-Johnson syndrome
Hypersensitivity reactions
Contraindications & Cautions
Contraindications
Hypersensitivity
Cautions
Not for use in systemic mycoses
Discontinue therapy if irritation or sensitization observed during use
Pregnancy & Lactation
Pregnancy category: C
Lactation: Not known if excreted in breast milk; use caution
Pregnancy Categories
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal
risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or
animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies
not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive
evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives
exist.
NA:Information not available.
Pharmacology
Mechanism of Action
Binds sterols in fungal cell membrane, altering permeability and thus causing cellular
contents to leak
Absorption
Poor PO absorption
Onset: Symptom relief for oral candidiasis 24-72 hr
Elimination
Excretion: Feces (as unchanged drug)
Patient Handout
nystatin topical
nystatin oral
Print w/ Office Info
Print w/out Office Info
62
Patient Education
nystatin topical
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT
have all possible information about this product. This information does not assure that this
product is safe, effective, or appropriate for you. This information is not individual medical
advice and does not substitute for the advice of your health care professional. Always ask
your health care professional for complete information about this product and your specific
health needs.
NYSTATIN POWDER - TOPICAL
(NYE-stat-in)
COMMON BRAND NAME(S): Nystop, Pedi-dri
USES:
Nystatin is used to treat fungal skin infections. Nystatin is an antifungal that works by
stopping the growth of fungus.
HOW TO USE:
Use this medication on the skin only. Clean and thoroughly dry the area to be treated. Apply
this medication to the affected skin, usually twice a day or as directed by your doctor. Dosage
and length of treatment depends on the type of infection being treated. Do not apply this more
often than prescribed.
Apply enough powder to lightly coat the affected area and some of the surrounding skin.
After applying this medication, wash your hands unless you are using this medication to treat
the hands. Do not wrap, cover or bandage the area unless directed to do so by your doctor. If
used in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.
Do not apply this medication in the eyes, nose, mouth, or vagina.
Use this medication regularly in order to get the most benefit from it. Remember to use it at
the same times each day.
Continue to use this medication until the full prescribed amount is finished, even if symptoms
disappear after starting nystatin. Stopping the medication too early may allow the fungus to
continue to grow, which may result in a return of the infection.
Inform your doctor if your condition persists after 2 weeks of treatment or worsens at any
time.
SIDE EFFECTS:
Skin irritation or redness may occur. If either of these effects persist or worsen, notify your
doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that
the benefit to you is greater than the risk of side effects. Many people using this medication
do not have serious side effects.
A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention
if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling
(especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above,
contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side
effects to Health Canada at 1-866-234-2345.
PRECAUTIONS:
Before using nystatin, tell your doctor or pharmacist if you are allergic to it; or if you have
any other allergies. This product may contain inactive ingredients, which can cause allergic
reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history.
This medication should be used only if clearly needed during pregnancy. Discuss the risks
and benefits with your doctor.
It is not known whether this drug passes into breast milk. Consult your doctor before breast-
feeding.
DRUG INTERACTIONS:
Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any
possible drug interactions and may be monitoring you for it. Do not start, stop or change the
dosage of any medicine before checking with them first.
Before using this medication, tell your doctor or pharmacist of all prescription and
nonprescription/herbal products you may use.
Keep a list of all your medications with you, and share the list with your doctor and
pharmacist.
OVERDOSE:
This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact
a poison control center or emergency room immediately. US residents can call their local
poison control center at 1-800-222-1222. Canada residents can call a provincial poison
control center.Symptoms that may occur after swallowing include: nausea, vomiting or
stomach upset.
NOTES:
Do not share this medication with others.
This medication should be used for your current condition only. Do not use it later for
another infection unless told to do so by your doctor. A different medication may be
necessary in those cases.
MISSED DOSE:
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip
the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
STORAGE:
Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and
moisture. Do not store in the bathroom. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
Properly discard this product when it is expired or no longer needed. Consult your pharmacist
or local waste disposal company for more details about how to safely discard your product.
Information last revised March 2013. Copyright(c) 2013 First Databank, Inc.
Patient Education
nystatin oral
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT
have all possible information about this product. This information does not assure that this
product is safe, effective, or appropriate for you. This information is not individual medical
advice and does not substitute for the advice of your health care professional. Always ask
your health care professional for complete information about this product and your specific
health needs.
NYSTATIN POWDER SUSPENSION - ORAL
(nye-STAT-in)
COMMON BRAND NAME(S): Barstatin, Nilstat
USES:
This medication is used to treat fungal infections of the mouth or intestines. Nystatin is an
antifungal that works by stopping the growth of fungus.
Nystatin powder for suspension should not be used to treat fungal infections of the blood.
HOW TO USE:
Unless otherwise instructed by your doctor, use this medication as follows: Add the
prescribed amount (usually 1/8 teaspoonful) of dry powder to a half glass (4 ounces or about
120 milliliters) of water. Stir well and divide the mixture into a number of smaller portions as
your doctor directs. Use all portions for each treatment. Each treatment must be used
immediately after mixing. Do not mix and store for later use.
Place one portion of the liquid in the mouth. Swish it around the mouth and gargle if so
directed. Keep the liquid in your mouth for as long as possible, then swallow or spit out as
directed. Use the other portions as your doctor directs. Ask your doctor or pharmacist for
more details. Avoid eating for 5-10 minutes after using this medication.
This medication is most often used four times a day or as directed by your doctor. It may take
from several days to several months to complete treatment. Use this medication regularly in
order to get the most benefit from it. Remember to use it at the same times each day. Dosage
is based on your medical condition and response to therapy.
Continue to use this medication until the full prescribed amount is finished, even if symptoms
disappear after a few days. Stopping the medication too early may allow the infection to
continue, resulting in a return of the infection.
Inform your doctor if your condition persists after several days of treatment or worsens at any
time.
SIDE EFFECTS:
Mouth irritation, diarrhea, nausea, vomiting, or stomach upset may occur. If any of these
effects persist or worsen, notify your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that
the benefit to you is greater than the risk of side effects. Many people using this medication
do not have serious side effects.
A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention
if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling
(especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above,
contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side
effects to Health Canada at 1-866-234-2345.
PRECAUTIONS:
Before taking nystatin, tell your doctor or pharmacist if you are allergic to it; or if you have
any other allergies. This product may contain inactive ingredients, which can cause allergic
reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially
of: HIV disease, diabetes, kidney disease.
Denture wearers need to be careful to properly clean and maintain their dentures during
treatment with this medication.
This medication should be used only when clearly needed during pregnancy. Discuss the
risks and benefits with your doctor.
It is not known whether this drug passes into breast milk. Consult your doctor before breast-
feeding.
DRUG INTERACTIONS:
Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any
possible drug interactions and may be monitoring you for it. Do not start, stop or change the
dosage of any medicine before checking with them first.
Before using this medication, tell your doctor or pharmacist of all prescription and
nonprescription/herbal products you may use.
Keep a list of all your medications with you, and share the list with your doctor and
pharmacist.
OVERDOSE:
If overdose is suspected, contact a poison control center or emergency room immediately. US
residents can call their local poison control center at 1-800-222-1222. Canada residents can
call a provincial poison control center.
NOTES:
Do not share this medication with others.
This medication has been prescribed for your current condition only. Do not use it later for
another infection unless told to do so by your doctor. A different medication may be
necessary in those cases.
MISSED DOSE:
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip
the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
STORAGE:
Refrigerate the powder between 36-46 degrees F (2-8 degrees C). Protect from light. Once
the container is opened, the powder is good for 90 days. Discard any unused portion after that
time.
After mixing, the liquid form must be used immediately. Do not store it for later use.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
Properly discard this product when it is expired or no longer needed. Consult your pharmacist
or local waste disposal company for more details about how to safely discard your product.
Information last revised March 2013. Copyright(c) 2013 First Databank, Inc.
