[Total No.
of Pages : 2 011 1 38
First M.B.B.S. (2019) Examination, (Phase - lll) Winter -2021
BIOCHEMISTRY - II
Total Duration : Section A+B = 3 Hours Section B Marks: 80
SECTION . B
lnstructions: 1) IJse btuelblack ball point pen only.
2) Do not wite anything on the blank pottion of the question Paper.
tf wriften anything, such type of actwillbe considered as an attempt
to resort to unfair means.
s) All questions are comPulsory.
4) The number to the right indicates full marks'
5) DraW diagrams wherever necessary.
6) Distribution of syllabus rn Question Paper is only meant to cover
entire syllabus within the stiputated frame. The Question paper
pattern is a mere guideline. Quesfions can be asked from any
'pape/s
'that syllabus inio any question paper. Sfudenfs cannot claim
the Question is qut of.syltabus. As if is only for the placement
sake, the distribution has been done.
[Jse a common answer book for section B'
2) Brief answer question (any Ten out of Eleven) : [10 x 2=201
Give the composition of Coenzyme A and write its function'
")
b) Functions of vitamin K.
c) TWo differences between colorimeter and spectrophotometer'
d) Write the role of chaPerons.
e) Name the bile salts and tests used for detection of bile salts.
0 Enlist amino acids involved in one carbon rnetabolism.
g) Action of carbonic anhydrase in acid base balance.
h) Enumerate the enzymes required for transcription.
D Write the products formed after pyrimidine catabolism.
) Write the importance of Wobble hypothesis'
k) Enumeratedeficiencymanifestationsofhypokalaemia.
P.T.O.
N-30
I
\l
01 11 38
3) Short answer question (any Eight out of Nine) : [8x5:401
a) Write piinciple, types and applications of ELISAtechnique.
b) Various types of normal hemoglobin.
c) What is proteinuria? Write its causes and clinical significance.
d) Functions of magnesium.
e) Typeiof body buffers in acid base balance.
0 A 30 year old male presented with history of intermittent abdominal
pain and episodes of confusion and psychiatric problerns. Laboratory
test revealed urinary delta-amino levulinate and porphobilinogen.
I. What is the probable diagnosis? (l mark) II. What is the pattern of
inheritance? (1 mark) III. Write reaction catalysed by the deficient
enzyme. (2 marks) IV. Give reason for the increase in colour of urine
when kept on standing. (1 mark)
g) A 9 year old girl presented with muscle pain and cramps' tingling of
hands and feet, stiffness, recurrent carpopedal spasms, and tetanic
posturing of both hands and feet. She was a strict vegetarian with
no milk or milk products.. Other siblings were normal. On
examination, Trousseau'S sign was positive. Calcium level was
6.5 mg/dl. I. What is the diagnosis? (1 mark) II.What are the causes
for the disease? (2 marks) III. What other investigation are needed
to come to a confirmatory diagnosis? (2 marks)
h) Principle and applications of polymerase chain reaction.
D Role of Vasopressin in water balance.
4) Long answer question (any Two out of Three) : x ra -- 201
12
a) How glycine is synthesized and metabolised? Explain its role in
biosynthesis of variety of specialized products. Add a note on inborn
disorders associated with metabolism of glycine.
b) Describe the metabolism, biochemical functions, deficiency manifestations
and toxicity of the vitamin Bl2 and folic acid.
c) Describe the metabolic changes during fed and starvation states with
role of specific organs.
VVVV
N-30 -2-
