Elite Psychiatry
Elite Psychiatry
psychiatry
HOW TO USE THIS NOTE
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                          FOR BETTER RESULTS
                          Start Early :
                          Use this notes as early as possible while learning the basic medical
                          science. The first semester of your first year is not too early! Devise a study
                          plan and make an early decision on resources to use and do not shift on
                          your resources. Its always better to keep things simple and stick to one
                          resource rather than confusing yourself with multiple sources.
                          BOX ANNOTATION :
                          We have introduced concept of Box annotation
                          1. RED BOX : Includes the most repeated topic along with the next
                             potential MCQ that we believe will be tested in future exam
                      Coined - Free association, Oedipus, penis envy, Id, ego and superego
                                                 - -
                      Cocaine in Psychiatry        Psychosexual Topographical theory
                      Psychodynamic theory         Development              of mind
                      Wrote book - Interpretation of dreams
  Alfred Adler     Coined - Inferiority complex
Approach to patient
Reliability of information
                                                          Previous Year Questions            AIIMS NOV17
• Relation to Patient                                   Q. Basis of reliability of information of patient
• Intimacy with the patient                             provided by informants depends on all except?
• Interest of the patient’
                                                     A. Biological relation
• Does the Informant live with the patient?
                                                     B. Educational status
                                                    :
• Duration of stay with the patient
                                                     C. Observation skill
• Intellectual and observational ability
                                                     D. Duration of stay with the patient
                                                                               burner    transference
                                                                                                  12
  Gait, freedom of movement, any unusual or sustained postures, pacing, and handwriting
 Speech
   Elements considered include fluency, amount, rate, tone, and volume.
Mood and affect
                Mood                                               Affect
                                                       Bipolar                 Schizophrenia
                                                                                                           13
 Thought           →    By Schneider
HEALTHY THINKING
   CONSTANCY- Persistence of a completed thought whether simple or complex.
   Organisation- Contents are related but do not blend with each other but organised
   Continuity- Thoughts or ideas are arranged in order
Disorders of thought
                     Stream                                      Content
           Flow of ideas
               1. Disorders of tempo-                1. Overvalued idea
                       i. Flight of ideas            2. Magical thinking
                       ii. Inhibition of thinking    3. Superstition
              2. Disorders of Continuing-            4. Delusion - Fixed, firm belief in
                      i. Perseveration                            something that is not a fact
                      ii. Thought blocking                        ( false fixed belief)
Possesion Form
Possesion
   Thought insertion                     Thought withdrawal               Thought broadcasting
 The patient believes that                The patient believes that    The patient believes that his
 thoughts that are not his own            thoughts have been taken     thoughts are broadcast so that he
 have been inserted into his mind.        away from his mind.          himself or others can hear them.
  Clanging              A severe form of flight of ideas whereby ideas are related only by
                       similar or rhyming sounds rather than actual meaning
                       Commonly seen in bipolar disorder (manic phase)
                        Eg:"I heard the bell. Well, hell, then I fell."
               Q
  Derailment            The words make sentences, but the sentences do not make sense.
                        Eg. "The next day when I'd be going out you know, I took control, like uh, I
                        put bleach on my hair in California."
                                                                                                 NEET 2021
                                                                          Predicted Question
                                                                    Previous   Year Questions
                                                               B. Obsession
  Loosening of associations- knight's move thinking.
                                                               C. Somatic delusion
       (Derailment)             In schizophrenia
                                                               D. Thought insertion
                                                                                                    15
Perception
Perceptual disturbances include hallucinations, illusions, depersonalization, and derealization.
             Hallucinations                                    Illusions
     False perceptions of internal stimuli               Misinterpretation of real stimuli
                        ( no stimuli present)
     Considered to be abnormal and associated         Considered to be fairly common to be
     with a pathological state of the mind            experienced by a healthy, normal individual
                                                                                                Q
                                                                  Depersonalisation is more
                                                                  common after life
                                                                  threatening trauma
depersonalization derealization
Insight
   Degree of personal awareness and understanding of illness
   The patient may have no insight, partial insight, or full insight.
   The amount of insight is not an indicator of the severity of the illness.
Insight scale
   1 . Complete denial of illness
   2. Slight awareness of being sick and needing help but denying it at the same time
   3. Awareness of being sick but blaming it on others, on external factors, on medical or
   unknown organic factors
   4. Intellectual insight: Admission of illness and recognition that symptoms or failures in
   social adjustment are due to irrational feelings or disturbances, without applying that
   knowledge to future experiences
   5. True emotional insight: Emotional awareness of the motives and feelings within, of the
   underlying meaning of symptoms.
                                                                                                      17
 Eg: "I know that there are not really little men talking to me when I am alone, but I
 feel like I can see them and hear their voices."
1 . Alertness (Observation)
 6. Fund of knowledge What is the distance between New York and Los Angeles? What body of
                      water lies between South America and Africa?
 7. Abstract reasoning Which one does not belong in this group: a pair of scissors, a canary,
                       and a spider? Why? How are an apple and an orange alike?
                                                                                                      18
Memory
                     encoding                              retrieving
                                                                                   Necessary
            When a person puts information             Ability to get information out
            into the "filing cabinet drawer."           of the "file cabinet drawer"
encoding                                   A
  It is usually measured by immediate recall of newly learned information (e.g., narrative
  stories or designs) or by demonstrating the ability to learn new material that has been
  presented across multiple "learning trials" (e.g., word lists).
a. Remote memory: Childhood data, important events known to have occurred when the patient
was younger or free of illness, personal matters, neutral material
b. Recent past memory: Past few months
c. Recent memory: Past few days, what did patient do yesterday, the day before, have for
breakfast, lunch, dinner
d. Immediate retention and recall: Ability to repeat six figures after examiner dictates them-first
forward, then backward, then after a few minutes' interruption; other test questions; did same
questions, if repeated, call forth different answers
at different times
e. Effect of defect on patient: Mechanisms patient has developed to cope with defect
Amnesia
 Loss of new learning ability that extends across all sensory modalities and stimulus domains.
      Anterograde amnesia: Decreased ability to retain new information
      Retrograde Amnesia: Loss of information that was acquired before the onset of amnesia.
                                                                                                 19
Neuropsychological tests
 The Mini–Mental State Examination (MMSE) or Folstein test is a 30-point questionnaire that is
 used extensively in clinical and research settings to measure cognitive impairment.
Classification in Psychiatry
The two most widely established systems of psychiatric classification are:
         Diagnostic and Statistical Manuel of Mental Disorders (DSM)
         International Classification for Diseases (ICD)
                    ICD 10                                     DSM 5
                      WHO                                     APA
             Used more in Europe and other             Official diagnostic system for
             parts of the world                        mental disorders in the US
               Different criteria for                    One version for both
               clinical and research use
                   All languages                                English
     Types of BFRB
      •   Skin
                 Dermatillomania (excoriation disorder), skin picking
                 Dermatophagia, skin nibbling
      •   Mouth
              Morsicatio buccarum, cheek biting
                 Morsicatio labiorum, inner lip biting
                 Morsicatio linguarum, tongue biting
      •   Hands
              Onychophagia, nail biting
                 Onychotillomania, nail picking
      •   Nose
              Rhinotillexomania, compulsive nose picking[2]
      •   Hair
                 Trichophagia, hair nibbling
                 Trichotemnomania, hair cutting
                 Trichotillomania, hair pulling
      •   Eyes
                 Mucus fishing syndrome - compulsion to remove or "fish"
                 strands of mucus from the eye
                          Q. Body focused repetitive behaviour comes under which OCD in ICD 11?
                            a. Hypochondriacal disorders         Predicted Question
                         Formal
   11 - end of         operations              Combinatorial system, whereby variables are
   adolescence                                 isolated and all possible combinations are
                     Abstract thinking
                                               examined; hypotheticodeductive thinking
                                                                                                       26
                             :
 Proposed by Sigmund Freud
 If the child experienced frustration at any of the psychosexual developmental stages, they would
 experience anxiety that would persist into adulthood as a neurosis, a functional mental disorder.
Latency 6–puberty
Genital Puberty–death
Latency
 Anal          Bowel and bladder     Anal retentive: Obsessively organized, or excessively neat
               elimination           Anal expulsive: reckless, careless, defiant, disorganized,
                                     coprophiliac
                                                      Q
Phallic          Genitalia           Oedipus complex (in boys and girls); according to Sigmund Freud.
                                     Electra complex (in girls); according to Carl Jung.
                                     Promiscuity and low self-esteem in both sexes.
  ID
       Pleasure principle
       Present at birth
       Primitive features that are driven by an
       unconscious need for pleasure
 Ego
       Reality principle
       Develops around the age of 2
       Reduces the conflict between Id and Superego
       by implementing defence mechanism
 Superego
    Morality principle
    Develops around the age of 5
    Internal morals that we learn from
    same sex parent, that punishes our
    ego for any wrong through guilt
                                                                                                       28
                                     Repression
                                   Conscious mind       Currently thinking
               =
               Pre- conscious Were thinking , Easily recollected
Consciousness
   Subjective phenomenon whose content can be communicated only by means of
   language or behavior.
   Perceptions coming from the outside world or from within the body or mind are brought
   into awareness.
preconscious
    Serves to maintain the repressive barrier and to censor unacceptable wishes and desires.
unconscious
    Characterized byprimaryprocess thinking, which is principally aimed at facilitating wish fulfill
    ment and instinctual discharge.
                                                                                                         29
Defense Mechanisms
Hypochondriosis Sexualization
Blocking Intellectualization
Narcissistic defenses:
                                        Q
  Most primitive and appear in children and persons                    Predicted Question
  who are psychotically disturbed.
                                                                     Q. Which one of these is a Mature
Immature defenses:
                                                                     defence mechanism ?
  Seen in adolescents and some nonpsychotic patients
                                                                     a. Somatization
Neurotic defenses:
                                        Q                            b. Rationalization
   Encountered in obsessive-compulsive and
                                                                     c. Anticipation
   hysterical patients, adults under stress.
                                                                     d.Projection
Mature defences:
   Commonly found among emotionally healthy adults
Narcissistic defenses
Immature defenses
   Acting out   Direct expression of an unconscious wish or impulse in action, without
                conscious awareness of the emotion that drives the expressive behavior
                 Eg: Instead of saying, “I'm angry with you,” a person who acts out may instead
                 throw a book at the person, or punch a hole through a wall.
                 Temper tantrum, Self harm
   Regression Reversion to an earlier stage of development
                 Eg: A person who is depressed may withdraw to his or her room, curl up in a
                 fetal position on the bed.
   Passive-   Indirect expression of hostility
   aggressive
              Eg: “She agreed to share her notes with me, but after class she went
   Behaviour
              straight home.”
   Schizioid    Tendency to retreat into fantasy in order to resolve inner and outer conflicts
   Fanatasy     Eg: A young boy who could not help his sick father due to shortage of money, day
                dreams that he has got lot of money from lottery ticket and his father, mother
                and family members has best of the facilities for everything.
   Somatization Psych problems becomes physical
                Eg: “ I had a terrible headache during the exam.”
Neurotic defenses
   Displacement Emotion or drive shifted to another person or object
                  Eg: A husband who is angry at his boss shouts at his wife on reaching home.
  Rationalization Convincing oneself that no wrong has been done and that all is or was all
                  right through faulty and false reasoning.
                   Eg: A husband does not enjoy the company of wife outside the the home and
                   usually leave his wife at home. He gives logic that his wife is social shy.
Mature defenses
  Altruism     Constructive service to others that brings pleasure and personal satisfaction
               Eg: A cruel CEO regularly donates to charity and takes part in the
               charity organization activities.
Anxiety Repression
      Phobia               Displacement
                           Regression
      Depression           Regression
                           Turning of aggression against self
                           Denial
      Mania
                           Projection
                           Regression
                          Projection
      Paranoid            Regression
                          Rationalisation
                          Regression
     Schizophrenia
                          Projection
                          Isolation of affect
                                                                                                         34
Dreams
  Conscious expression of unconscious fantasies or wishes not readily acceptable to conscious waking
  experience.
  The analysis of dreams elicits material that has been repressed (hidden).
  These unconscious thoughts and wishes include
          Nocturnal sensory stimuli
               (sensory impressions such as pain, hunger, thirst, urinary urgency),
           Day residue
              (thoughts and ideas that are connected with the activities and
                preoccupations of the dreamer's current waking life),
          Repressed unacceptable impulses
                                                                                 Not understood by
  Understood by                     layers of dream content                    clients, needs help for
client themselves                                                                     decoding
         The manifest content refers to            The latent content involves the
         what is recalled by the dreamer           unconscious thoughts and wishes that
                      v
                                                   threaten to awaken the dreamer
                                                                     v
 Dream Work
   Conscious process that transforms latent content into manifest content.
   E
                                                 Condensation
 All our internal
 conflicts, ideas,
                                                 Displacement
      desires                                                                      Manifest
 -                                                                                  Dream
  Latent layer of                                 Projection
                                                                              (What we can see
  dream content
                                                   Symbolic                    as our dream)
                                                Representation
A psychiatrist after listening to the manifest dream of the client helps them to
trace it back to understand the latent dream.
primary process
  Condensation
  Mechanism by which several unconscious wishes, impulses, or attitudes can be combined
  into a single image in the manifest dream content.
   •             Bk           •
                                       } Unconscious wishes / impulses
✓ V L
 Eg: In a child’s nightmare an attacking monster may be a representation of not only his father but
 also some aspects of his mother and even the child’s own hostile conditions in an abusive family.
 Diffusion
  The converse of condensation
  An irradiation or of a single latent wish or impulse that is distributed through multiple repre-
  sentations in the manifest dream content.
                 •
                                  } Unconscious wishes / impulses
                 ~
       L                  ✓
  Displacement
  The mechanism of displacement refers to the transfer of amounts of energy (cathexis)
  from an original object to a substitute or symbolic representation of the object.
   Eg: In a dream mother may be represented visually by an unknown female figure
  Projection
   Allows dreamers to rid themselves of their own unacceptable wishes or impulses and experience
   them as coming from another person or independent sources.
   Eg: A person who wants to be unfaithful to his wife may dream that his wife has been unfaithful to
   him.
  Symbolic Representation
  An abstract concept or a complex set of feelings toward a person could be symbolized by a
  simple, concrete, or sensory image.
 secondary process
   Secondary Revision
    Dreams become somewhat more rational.
    A more mature and reasonable aspect of ego works during dreams to organise primitive aspects
    of dream into a more logical form.
   Affects in Dreams
   Secondary emotions may not appear in the dream at all, or they may be
   experienced in somewhat altered form.
   Eg: Repressed rage toward a person's father may take the form of mild annoyance.
Punishment Dreams
    Dreams in which dreamers experience punishment
     Reflects a compromise between the repressed wish and the repressing agency or conscience.
     The wish for punishment on the part of the patient's conscience is satisfied by giving
     expression to punishment fantasies.
Psychoanalysis techniques
free association
   Requires patients to tell the analyst everything that comes into their heads-however
   disagreeable, unimportant, or nonsensical
   To let themselves go
   Patient's thoughts into words
   Eg: "cabbages to kings."
                                                                                          37
 Hypnosis
   State in which the person is relaxed and drowsy, and more suggestible than usual.
 Abreaction
   Reliving an experience to purge it of its emotional excesses
    In this process the person not only recalls but also relives the repressed
    material causing an emotional release
    Eg: A rape victim forgets the incident happened by recalling the repressed memories
    with emotional outburst
   Type of catharsis
 Catharsis
     Emotional release
     Primary through art
     Purification and purgation of emotions—particularly pity and fear—through art
4 components of Psychoanalysis
                                                                                                  38
Predicted Question
                          Q
            39
 Stage 1
 Infancy
 Stage 2
  Early
childhood
 Stage 3
Preschool
              40
 Stage 4
School age
  Stage 5
Adolescent
  Stage 6
Young adult
            41
 Stage 7
  Middle
adulthood
 Stage 8
Maturity
                                                                                                      42
Projective Tests
 *
Sleep
 Naturally recurring state of mind and body, characterized by altered consciousness, relatively
 inhibited sensory activity, reduced muscle activity and inhibition of nearly all voluntary muscles
 during rapid eye movement (REM) sleep,and reduced interactions with surroundings.
               NREM                                   REM
            Non-rapid eye                           Rrapid eye
           movement sleep                         movement sleep.
                                                Paradoxical sleep
     N1        N2         N3       N4           Main occasion for dreams and nightmares
          :
          Largest       Delta sleep or          Saw tooth waves
          percentage slow-wave sleep
          of sleep time Deepest sleep           N1         N2           N3          N2         REM.
Insomnia Disorder
  Difficulty falling asleep or staying asleep is characteristic of insomnia disorder.
  Non organic insomnia
     A. The individual complains of difficulty falling asleep, difficulty maintaining sleep, or
     nonrefreshing sleep.
     B. The sleep disturbance occurs at least 3 times a week for at least 1 month.
     C. The sleep disturbance results in marked personal distress or interference with
     personal functioning in daily living.
     D. There is no known causative organic factor, such as a neurological or other medical
     condition, psychoactive substance use disorder, or a medication.
   Primary insomnia is characterized both by difficulty falling asleep and by repeated awakening.
   Primary insomniais commonly treated with benzodiazepines, zolpidem, eszopiclone
   (Lunesta), zaleplon (Sonata), and other hypnotics.
 melancholia
    "Endogenous depression"
     Severe form of major depression
                                                                 Q
     Characterized by severe anhedonia, early morning awakening, weight loss,
     and profound feelings of guilt (often over trivial events).
     Also carries with it a high risk of suicide
                                                         Previous Year Questions         AIIMS 2019
                                                         What are the features of Melancholia?
                                                                                         45
Narcolepsy
  Disorder characterised by excessive day- time sleepiness, often disturbed night-
  time sleep and disturbances in the REM-sleep.
  The hallmark of this disorder is decreased REM latency,
  i.e. decreased latent period before the first REM period occurs
          These are vivid perceptions, usually dream-like, which occur at the onset of
          sleep and are associated with fearfulness.
          When these occur at awakening, they are called hypno pompic hallucinations.
   iv. Sleep paralysis (least common):
         This occurs either at awakening in the morning (usually) or at sleep onset.
         The person is conscious but unable to move his body.
         The episode may last from 30 seconds to a few minutes and may cause
         significant distress.
Kleine-Levin Syndrome
•
    Narcolepsy is due to the decrease in orexin/hypocretin from lateral hypothalamus which is
    responsible for promoting wakefulness.
    Treatment - Modafinil (DOC), Armodafinil {dopamine reuptake inhibitors}
                Almorexant, Suvorexant, Lemborexant {orexin receptor antagonist}
•
    Restless Leg Syndrome - always rule out Fe deficiency, uremia & pregnancy
•
    Somnambulism
    - Max seen between 4-8yrs of age
    - They don’t harm themselves or others during such episodes
    - Treatment: Benzodiazepines, TCA {reduce NREM 3 sleep}
•
    Somniloquy
    - Sleep talking seen during NREM 3 sleep
Sleep-Related Bruxism
  Teeth grinding occurs in any sleep stage but appears to be most com mon at
  transition to sleep, in stage 2 sleep, and during REM sleep.
        It worsens during periods of stress.          Predicted Question
Sleepwalking
  The predominant symptom is repeated (two or more) episodes of rising from bed, usually during
  the first third of nocturnal sleep, and walking about for between several minutes and half an hour.
  During an episode, the individual has a blank, staring face, is relatively unresponsive to the efforts
  of others to influence the event or to communicate with him or her, and can be awakened only with
  considerable difficulty.
  Upon awakening (either from an episode or the next morning), the individual has amnesia for the
  episode.
  Within several minutes of awakening from the episode, there is no impairment of mental activity
  or behavior, although there may initially be a short period of some confusion and disorientation.
  There is no evidence of an organic mental disorder, such as dementia, or a physical disorder, such
  as epilepsy.
Polysomnography
   Continuous, attended, comprehensive recording of the biophysiological
   changes that occur during sleep.
   Each 30-second segment of the recording is considered an "epoch."
        Typically recorded at night and lasts between 6 and 8 hours.
         Gold Standard diagnosis of sleep disorder.
  ooh
        The following are measured
            Brain wave activity (EEG from occipital and parietal leads)         respiratory effort
            eye movements (EOG)                                                 oxyhemoglobin saturation
            submental electromyography activity (EMG)                           heart rhythm (ECG)
            nasal-oral airflow                                                  leg movements during sleep
        Indications
           (1) diagnosis of sleep-related breathing disorders,
           (2) positive airway pressure titration and assessment oftreatment efficacy,
           (3) evaluation of sleep-related behaviors that are violent or may potentially harm
           the patient or bed partner.
                                                                                               48
hypnogram
   A form of polysomnography; it is a graph that represents the stages of sleep as a
   function of time.
   It was developed as an easy way to present the recordings of the brain wave activity
   from an electroencephalogram during a period of sleep.
                                                 Q
     Previous Year Questions      AIIMS 2018           Previous Year Questions     NEET 2019
   Identify the investigation from the graph ?        What are the features of Somnambulism?
Hierarchy of needs
                                                                                                      49
                  :
 Abraham Maslow’s hierarchy of needs is a theory of psychology explaining human motivation based
 on the pursuit of different levels of needs.
 The theory states that humans are motivated to fulfill their needs in a hierarchical order. This order
 begins with the most basic needs before moving on to more advanced needs.
 The ultimate goal, according to this theory, is to reach the fifth level of the hierarchy:
 self-actualization.
Learning theories
                                                                                            50
Operant conditioning
                                     Positive                           Negative
                                   Applies Stimulus                    Applies Stimulus
   Reinforcement
 Increases the frequency               Positive                              Negative
 of desirable behaviour              Reinforcement                          Reinforcement
     Punishment                                                             Negative
                                       Positive
 Decreases the frequency              Punishment                             Punishment
 of desirable behaviour
Premack principle
  Operant conditioning                         First                 Then
   Theory of reinforcement that states that a less desired behavior can be
   reinforced by the opportunity to engage in a more desired behavior.
  "Grandma's rule"         First you eat spinach then you can have candy.
                                                                                                  51
Classical conditioning
(also known as Pavlovian or respondent conditioning)
Psychotic Disorders
Psychosis Neurosis
Delusions
  A fixed belief that is not amenable to change in light of conflicting evidence.
      Bizarre delusion                                 Non-bizarre delusion
 Clearly implausible and not understandable           A delusion that, though false, is at least
 to same-culture peers and do not derive              technically possible
 from ordinary life experiences
                                                                        v
  Any delusion with content consistent                   A delusion that does not relate to the
  with either a depressive or manic state.               sufferer's emotional state;
                   v                                                          r
  Eg: a depressed person believes that news             Eg: a belief that an extra limb is growing
  anchors on television highly disapprove of            out of the back of one's head is neutral to
  them, or a person in a manic state might              either depression or mania.
  believe they are a powerful deity.
                                                                                                     54
Types of Delusions
  Erotomanic type: This subtype applies when the central theme of the delusion is that another
  (De Clarembault) person is in love with the individual.
                  :
  Grandiose type:    This subtype applies when the central theme of the delusion is the conviction
                     of having some great (but unrecognized) talent or insight or having some
                     important discovery.
  Jealous type:      This subtype applies when the central theme of the individual's delusion
   (Othello)         is that his or her spouse or lover is unfaithfuI.
   Prosecutory type: This subtype applies when the central theme of delusion involves the
    (Nihilistic)     individual's belief that he or she is being conspired against, cheated, spied
                     on, followed, poisoned or drugged, maliciously maligned, harassed, or
                     obstructed in the pursuit of long-term goals.
    Somatic type:     This subtype applies when the central theme ofthe delusion involved bodily
                      functions or sensations.
   Mixed type:       This subtype applies when no one delusional theme predominates.
   Unspecified type: This subtype applies when the dominant delusional belief cannot
                     be clearly determined or is not described in the specific types
                     (e.g., referential delusions without a prominent persecutory or
                     grandiose component).
                                                                                                        55
                  :
    Advanced age                                              Q. Which of the following is not a risk
    Sensory impairment or isolation                           factor for Delusional Disorders?
    Family history                                            A. Young age
    Social isolation                                          B. Family history
    Personality features                                      C. Isolation
    Recent immigration                                        D. Recent immigration
Fregoli delusion A person holds a delusional belief that different people are in fact a single
                 person who changes appearance or is in disguise.
Nihilistic delusions Delusional belief of being dead or even not existing entirely as a human being.
Cotard delusion A false belief that you or your body parts are dead, dying, or don't exist.
REACTIVE PSYCHOSIS
  1. A sudden onset of symptoms.
  2. Presence of a major stress before the onset (the quantum of stress
  should be severe enough to be stressful to a majority of people).
  3. A clear temporal relation between stress and the onset of psychotic symptoms.
  4. No organic cause underlying the psychosis.
                                                                                                   56
CAPGRAS’ SYNDROME
(THE DELUSION OF DOUBLES)
 1. Typical Capgras’ syndrome (Illusion des sosies):
 Here the patient sees a familiar person as a complete stranger who is imposing on him
 as a familiar person.
 2. Illusion de Fregoli: The patient falsely identifies stranger(s) as familiar person(s).
 3. Syndrome of subjective doubles: The patient’s own self is perceived as being replaced
 by a double.
 4. Intermetamorphosis: Here the patient’s misidentification is complete and the patient
 misidentifies not only the ‘external appearance’ (as in the previous three types) but
 also the complete personality.
                  Predicted Question
              Previous    Year Questions                                              AIIMS 2017
               A young patient is admitted with acute psychosis. He wakes up and asks for his
               Wife. Upon pointing her out He denies that it is his wife and claims that she is
               an imposter. What is the diagnosis?
Schizophrenia
      1. Auditory hallucinations
      2. Broadcasting, insertion/                  1. Flattened affect
             withdrawal of thoughts                2. Avolition - Apathy &
      3. Bizarre behaviour                                          loss of drive
      4. Controlled feelings,                      3. Autism - Social isolation
                 impulses or acts                                  & withdrawal
                                                                                  Q
      5. Delusions esp persecutory                 4 Alogia - Poverty of speech
      6. Disorganised thought                      5. Poor self care
                             :
ICD -11 criteria of diagnosis
   Episode lasting for at least 1 month
Dopamine in schizophrenia ②
D2 receptor activation
                                                              Decreased activity of
                                                              the nucleus caudatus
                                                                  •
Endophenotypic markers of genetically transmitted schizophrenia
• Smooth pursuit eye movements
• Anti saccadic eye movement
• P50 auditory evoked potential
• Pre pulse inhibition
                                                                                                  61
                                 Catatonic Schizophrenia
                                               ✓
                                                             ⑧
 excited catatonia               stuporous catatonia              Catatonia alternating between
                                                                      excitement and stupor
Management
  1. Somatic treatment
  a. Pharmacological treatment:
        Atypical (or the second generation) antipsychotic drugs, such as risperidone,
        olanzapine, quetiapine, aripiprazole, and ziprasidone, are more commonly used.
  b. Electro-convulsive therapy (ECT) - Schizophrenia is not a primary indication
  c. Miscellaneous treatments- Limbic leucotomy (not routinely indicated)
  2. Psychosocial treatment and rehabilitation.
             Psychoeducation
             Group psychotherapy
             Family therapy
             Milieu therapy (or therapeutic community)
             Individual psychotherapy
             Psychosocial rehabilitation
                                                                                                 63
Mood Disorders
Hypomania
  Similar to a maniac episode and last at least 4 days
  Not sufficiently severe to cause impairment in social or occupational functioning
Dysthymia
  Low mood occurring for at least two years, along with at least two other symptoms
  of depression.
                                                                                                         64
 Cyclothymia
   Characterized by marked swings of mood between depression and elation for at least two years
 Bipolar I disorder
   A clinical course of one or more manic episodes and sometimes major depressive episodes.
 Bipolar II disorder     Q
Mania
 Manic syndrome:- State of abnormally elevated arousal, affect, and energy level
 During a manic episode, an individual will experience rapidly changing emotions and moods,
 highly influenced by surrounding stimuli.
 Although mania is often conceived as a "mirror image" to depression, the heightened mood can
 be either euphoric or dysphoric.
symptoms                                                 Previous Year Questions
                                                             Predicted Question           NEET 2021
    elevated mood (either euphoric or irritable),
    flight of ideas                                          Q. 16 year old female patient
    pressure of speech,                                      presented with overfamiliarity, flight of
    increased energy,                                        ideas, elevated mood, increased sexual
    decreased need and desire for sleep,                     desires, pseudo hallucinations. What is
    hyperactivity.                                           the diagnosis?
  To be classified as a manic episode, while the disturbed mood and an increase in goal-
  directed activity or energy is present, at least three (or four, if only irritability is
  present) of the following must have been consistently present:
    1 Inflated self-esteem or grandiosity.
    2 Decreased need for sleep (e.g., feels rested after 3 hours of sleep).
    3 More talkative than usual, or acts pressured to keep talking.
    4 Flights of ideas or subjective experience that thoughts are racing.
    5 Increase in goal-directed activity, or psychomotor acceleration.
    6 Distractibility (too easily drawn to unimportant or irrelevant external stimuli).
    7 Excessive involvement in activities with a high likelihood of painful consequences.
        (e.g., extravagant shopping, improbable commercial schemes, hypersexuality).[18]
                                                                                                              65
Treatment
  The acute treatment of a manic episode of bipolar disorder involves the utilization of either
  Mood stabilizer
       Carbamazepine,       lithium,
       valproate,           lamotrigine
  Atypical antipsychotic
       olanzapine,          risperidone,
       quetiapine,          aripiprazole
  When the manic behaviours have gone, long-term treatment then focuses on prophylactic
  treatment to try to stabilize the patient's mood, typically through a combination of
  pharmacotherapy and psychotherapy.
                                                                    “omega melancholicum”
   Triangular palpebral folds running diagonally from            Resembles Greek alphabet ‘Ω’
   the lateral corners of the eyes, medially upward to   Vertical wrinkling between the eyebrows joined
   the medial end of the eyebrows                        at the top by a horizontal crease (white arrow)
Atypical depression
 According to the DSM-IV, symptoms of depression with atypical features include the following
   A Mood reactivity (i.e., mood brightens in response to positive events)
   B Two or more of the following features, present for most of the time, for at least two weeks:
      1 Increased appetite
      2 Increased sleep
      3 Leaden paralysis (i.e., heavy, leaden feelings in arms or legs)
      4 Interpersonal rejection sensitivity (not limited to episodes of mood disturbance)
          resulting in significant social or occupational impairment
   C Criteria are not met for melancholic or catatonic features of depression.
Cognitive distortions
  Beck proposes that those with depression develop cognitive distortions
  Faulty or unhelpful thinking patterns.
       The primary goal in the acute phase is to achieve a response using psychotherapy,
       medications, or a combination of the two forms of therapy, eventually resulting in
       remission. (Paradoxical suicide in Acute phase)
       Response: A significant improvement in depressive symptoms, although residual
       symptoms are usually present.
       Remission is achieved when the patient has achieved a full restoration of normal
       capacity for social and occupational function.
       The goal in the continuation phase of treatment is to prevent relapse, and this phase
       lasts for up to 9 months.
       The maintenance phase of treatment typically lasts for a year after a patient's first
       episode of depression, but may continue indefinitely, depending on the patient's likelihood
       risk for recurrence.
                                                                                                          70
  •
    A combination of psychotherapy and pharmacotherapy is the most effective treatment for
    major depressive disorder.
psychotherapy
   Cognitive Behavioral Therapy (CBT) is one of the most common types of talk therapy
   used in the treatment for depression
             Education (pinpointing the life problems that contribute to a patient's depression
             & which aspects of those problems they may be able to solve or improve)
             Improving self-esteem (a patient's sense of self-regard, confidence & hope)
             Psychological (ego) functioning (cognitive abilities, affect regulation, morals &
             ability to relate to others)
             Adaptive skills (behaviors associated with effective function with friends, family &
             coworkers)
      Interpersonal Therapy
          Consists of 12 to 1 6 weekly sessions and is characterized by an active therapeutic approach.
   Behavior Therapy
       By addressing maladaptive behaviors in therapy, patients learn to function in the
       world in such a way that they receive positive reinforcement.
pharmacotherapy
                                      AIIMS 2018
      Patients with atypical depression respond
      effectively to treatment with MAOIs and
      SSRIs than TCAs
                     71
Somatic modalities
                                                                                                                 72
       Symptoms may meet syndromal criteria for            Any symptoms as defined by DSM-5
       major depressive episode, but the survivor
       rarely has morbid feelings of guilt and
       worthlessness, suicidal ideation, or
       psychomotor retardation
        Considers self bereaved                             May consider self weak, defective, or bad
Stages of grief
                           Q
 Proposed by Kubler-Ross
    Mnemonics
   D         Denial
   A         Anger
   B       Bargaining
   D       Depression
   A       Acceptance
                                                                                                    74
Bipolar disorder
   Recurrent episodes of mania and depression in the same patient at different times
                                                                                                          75
                                                             Hypomania
                                                   Mania
       Normal mood                                                       Mixed episode
                   Depression
                                    Subsyndromal
                                     depression
                                                        Depression
           Mania
Bipolar in mania
  Bipolar mood disorder has an earlier age of onset (third decade) than recurrent depressive
  (unipolar) disorder.
  Unipolar depression is common in two age groups: late third decade and fifth to sixth decades.
  An average manic episode lasts for 3-4 months
  A depressive episode lasts from 4-6 months.
  Unipolar depression usually lasts longer than bipolar depression.
                                                                                      76
rapid cyclers
  Patients with bipolar mood disorder have more than 4 episodes per year.
  About 70-80% of all rapid cyclers are women.
ultra-rapid cycling
   When phases of mania and depression alternate very rapidly (e.g. in matter of
   hours or days)
Factors associated with rapid cycling
      Use of antidepressants (especially tricyclic antidepres- sants),
      low thyroxin levels,
      female gender,
      bipolar II pattern of illness,
      Presence of neurological disease.
                                                Rapid cycling
Normal mood
                        Depression
                                           l           12 months
Prognostic Factors
  Good Prognostic Factors
  1. Acute or abrupt onset
  2. Typical clinical features
  3. Severedepression
  4. Well-adjusted premorbid personality
  5. Good response to treatment.
                                Antimaniac
                  A
                 2014           Bipolar in depression
                                                        Bipolar in normal
             Bipolar in Mania          B                                    Mood stabilisers
                                      2015        2016
                                                    C
                                               Antidepressants
                                Neurotic disorders
         Anxiety disorder
                Generalised Anxiety Disorder
                Phobic disorders
                Panic disorders
          Obsessive- Compulsive and related disorders (OCD)
                OCD
                Hoarding disorder
                Trichotillomania
                Skin picking disorder
                Body Dysmorphic Disorder
         Trauma and Stress - related disorders
             Acute stress reaction
             Adjustment disorders
             Post- traumatic stress disorder
         Dissociative disorders
               Dissociative Fugue
               Dissociative identity disorder
               Depersonalisation and Derealization
               Dissociative Amnesia
         Somatic Symptom and Related disorders
              Somatic Symptom Disorder
              Illness anxiety disorder
              Pain disorder
              Functional neurological symptom disorder
Anxiety disorder
 Generalized anxiety disorders
      Anxiety is continous, although it may fluctuate in intensity.
 Phobic anxiety disorders
      Anxiety is intermittent, arising in particular circumstances.
 Panic disorder
     Anxiety is intermittent, but its occurrence is unrelated to any particular circumstances.
                           Previous Year Questions                                        NEET 2020
                              Q.A Medical student     presented to opd with intermittent episodes of
                                              Predicted Question
 Sleep disturbance
       Insomnia
       Night terror
 Associated
                          Avoidance               Escape                        Agitation
 behaviour
  Somatic
                          With exposure             Episodic                   Persistent
  Symptoms
                                                                                               80
                                  ni
                                Feeling of impending doom             anxiety disorder
        Episodic                          Episodic
                                                       Panic attack     Always worried
                                                                         Continuous
                                                                      -
N For 6 months
PHOBIC DISORDER
   Irrational fear of a specific object, situation or activity, often leading to persistent
   avoidance of the feared object, situation or activity.
(Most common)
Treatment of Phobia
                                                      Drug Treatment
                         :
  Behaviour Therapy
    1. Flooding.                              Benzodiazepines
    2. Systematic desensitisation.            Alprazolam (DOC) is stated to have anti-
    3. Exposure and response prevention.      phobic, anti-panic and anti-anxiety properties.
    4. Relaxation techniques.                  Antidepressants
                                               SSRIs( DOC)
                                                 - paroxetine (most widely used drug)
          Graded exposure
                                                            Sudden exposure
                 +
             Relaxation
                                             Better              Flooding
        Systemic desensitisation
                                                                                                      84
obsession
  1. An idea, impulse or image which intrudes into the conscious awareness repeatedly.
  2. One’s own idea, impulse or image but is perceived as ego-alien (foreign to one’s personality).
  3. Recognised as irrational and absurd (insight is present).
  4. Patient tries to resist against it but is unable to.
                                                                  Compulsions may diminish
  5. Failure to resist, leads to marked distress.                 the anxiety associated
                                                                     with obsessions.
compulsion
  1. Usually follows obsessions.
  2. Aimed at either preventing or neutralising the distress or fear arising out of obsession.
  3. The behaviour is not realistic and is either irrational or excessive.
  4. Insight is present, so the patient realises the irrationality of compulsion.
  5. The behaviour is performed with a sense of subjective compulsion (urge or impulse to act).
Treatment
  Psychotherapy
     Psychoanalytic psychotherapy
     Supportive psychotherapy
  Behaviour Therapy and Cognitive Behaviour Therapy
     i. Thought-stopping (and its modifications).
     ii. Response prevention.
     iii. Systematic desensitisation.
     iv. Modelling.
  Drug Treatment
     Benzodiazepines (e.g. alprazolam, clonazepam)
     Antidepressants ( e.g. Clomipramine, Fluoxetine)
     Antipsychotics (e.g. haloperidol, risperidone, olanzapine, aripiprazole, pimozide)
     Buspirone
  Electroconvulsive Therapy
  Psychosurgery
    i. Stereotactic limbic leucotomy.
    ii. Stereotactic subcaudate tractotomy.
                                                                                                             87
Treatment of OCD
  DOC : SSRI
                                                                Therapy : ERP
        •    fluoxetine                            Exposure and Response prevention
        •    fluvoxamine
                 Do not respond                    Make the                        Don’t make
                         Be                        hands dirty                     him wash
            Clomipramine
   (The 1st FDA approved drug for OCD)
             Most effective
                                                              Predicted Question
                           •
             Resperidone
                                                       Q. Treatment of choice in OCD?
       (augmentation strategies
           in resistant OCD)
                                                      A. SSRI
                                                      B. ECT
                                                      C. CBT
                                                      -
               ECT
       ( for comorbid depression )                    D. Psychoanalytic psychotherapy
             Psychosurgery
                             Q
            “ Cingulotomy”
Hoarding Disorder
    Characterized by acquiring and not discard ing things that are deemed to be of
    little or no value, resulting in excessive clutter of living spaces.
    Challenges posed by hoarding patients to typical CBT treatment include poor insight
    to the behavior and low motivation and resistance to treatment.
    The most effective treatment for the disorder is a cognitive behavioral model that
    includes training in decision making and categorizing; exposure and habituation to
    discarding; and cognitive restructuring.
trichotillomania
   Hair-pulling disorder
   Chronic disorder characterized by repetitive hair pulling, leading to variable
   hair loss that may be visible to others.
   There is an intense urge to pull out hair with mounting tension before the act
   and a sense of relief afterwards.
    The management of impulse control disorders consists of behaviour therapy (e.g. aversion
    therapy), cognitive behaviour therapy (CBT), individual psychotherapy, and occasionally
                                                                                        Q
    pharmacotherapy (e.g. carbamazepine for intermittent explosive disorder; fluoxetine for
    trichotillomania).
                                                                                                             89
Diogenes syndrome
 •
  Diogenes Syndrome is a behavioral disorder that affects older adults.
 •
  It occurs in both men and women.
 •
  The main symptoms are excessive hoarding, dirty homes, and poor personal hygiene.
 •
  People with Diogenes syndrome also withdraw from life and society.
  They often live alone and are unaware that anything is wrong with the condition of their
Timeline
  Timeline of events that occur after a stressful event                    Dysthmia
                                                                           (chronic depression)
             Acute stress                                  Adjustment      Cyclothymia
                                      Depression
               reaction                                     disorder       (mood swings)
    Stress
    Event        <2days 2days- 1month >2wks >1month <6months >6months >2yrs
                                                                        Chronic
                         Acute stress
                           disorder                 PTSD                 grief
                      Timeline in Psychiatry
                          Mania       1 week
                     Hypomania        4 consecutive days
      Major Depressive Disorder       >= 2 weeks for 6 - 12 months
                   Cyclothymia        >= 2 years
                     Dysthymia        >= 2 years
                Maternal Blues        2 weeks
 Post Partum Mood disturbances        Within 4 weeks of delivery
       Brief Psychotic Disorder       < 1 month                              Tourette
     Schizophreniform disorder        1 - 6 months                            < 18 years age onset
                                                                             ••
Treatment of PTSD
  1. Prevention: Anticipation of disasters in the high risk areas, with the training of personnel
  in disaster management.
  2. Disaster management: Here the speed of providing practical help is of paramount
  importance. This is also a preventive measure.
  3. Supportive psychotherapy.
  4. Cognitive behaviour therapy (CBT).
  5. Drug treatment: Antidepressants and benzodiazepines (in low doses for short periods) are
  useful in treatment, if anxiety and/or depression are present.
      mood even worse. He was more irritated towards the people in his home, but
      occasionally went for a movie with his friends and was able to enjoy with them
      but after returning back to his home, he again had similar symptoms.
      What is the probable diagnosis?
      A. Adjustment disorder
                                                                                                    94
Adjustment disorder
 Mental symptoms include:
              •   rebellious or impulsive actions
                                                                        •   withdrawn attitude
              •   anxiousness
                                                                        •   lack of concentration
              •   feelings of sadness, hopelessness, or being trapped
                                                                        •   loss of self-esteem
              •   crying                                                •   suicidal thoughts
   Clinical Subtypes
      1. Adjustment disorder with depressed mood
      2. Adjustment disorder with anxiety
      3. Adjustment disorder with disturbance of conduct
      4. Adjustment disorder with disturbance of emotion and conduct
   Treatment
       1. Supportive psychotherapy remains the treatment of choice.
       2. Crisis intervention
       3. Stress management training and Coping skills training.
       4. Drug treatment anxiety (benzodiazepines) and/or depressive symptoms (antidepressants)
DSM-5 Diagnosis
Symptoms
Cause
Treatment
                                                                                               95
Dissociative Disorders
Depersonalization
     Alexithymia, or an inability to recognize or describe emotions
     Feeling physically numb to sensations
     Feeling robotic or unable to control speech or movement
     Feeling unconnected to your body, mind, feelings, or sensations
     Inability to attach emotions to memories
     The sense that your body and limbs are distorted (swollen or shrunken)
     The sense that your head is wrapped in cotton
Derealization
     Distance and the size or shape of objects may be distorted.
     You may have a heightened awareness of your surroundings.
     Recent events may seem to have happened in the distant past.
     Surroundings may seem blurry, colorless, two-dimensional, unreal, or larger-than-
     life or cartoonish.
          Conversion disorder
            Loss of functioning in some part of the body for psychological rather than physical reasons
            Patient is not bothered by/ is comfortable in spite of symptoms.
            La belle indifference.
 ik
          Somatization disorder
             History of complaints about physical symptoms, affecting many different areas of the
             body, for which medical attention has been sought but no physical cause found
ik
          Pain disorder
             History of complaints about pain, for which medical attention has been sought
             but that appears to have no physical cause
 ik
          Hypchondriasis
             Chronic worry that one has a physical disease in the absence of evidence that one does;
             frequently seek medical attention
     ik
          Body dysmorphic disorder
             Excessive preoccupation with some part of the body the person believes is defective
                                                                                              97
Factitious Disorder
   Also called Munchausen syndrome,
   Deliberate feigning of physical or psychological symptoms to assume the sick role.
   Factitious disorder is distinguished from malingering in which symptoms are also falsely
   reported; however, the motivation in malingering is external incentives, such as
   avoidance of responsibility, obtaining financial compensation, or obtaining substances.
   Pseudologia fantastica
      The patients distort their clinical histories, laboratory tests’ reports,
      and even facts about other aspects of their lives
   Factitious disorder by proxy
       Factitius disorder imposed on another is when one person presents the other
       person as ill, most often mother and child.
   Grid-iron abdomen
       Evidence of earlier treatment, usually surgical procedures, is often available
       in the form of multiple scars
                                                                          98
Ganser Syndrome
   Seen in prisoners under trial
 : Conversion symptoms, hallucinations, confusion, approximate answers.
                                                                                                    99
                              Neurocognitive Disorders
Organic mental disorders
  Reduced brain function due to illnesses that are not psychiatric in nature.
    F00 Dementia in Alzheimer’s disease
    F01 Vascular dementia
    F02 Dementia in other diseases classified elsewhere
    F03 Unspecified dementia
    F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
    F05 Delirium, not induced by alcohol and other psychoactive substances
    F06 Other mental disorders due to brain damage and dysfunction and to physical disease
    F07 Personality and behavioural disorders due to brain disease, damage and dysfunction
    F09 Unspecified organic or symptomatic mental disorder
Dementia
Progressive cognitive impairment in clear consciousness.
 1. Impairment of intellectual functions,
 2. Impairment of memory (predominantly of recent memory, especially in early stages),
 3. Deterioration of personality with lack of personal care
 Additional features
     Emotional lability - marked variation in emotional expression.
     Catastrophic reaction- when confronted with an assignment which is beyond the residual
     intellectual capacity, patient may go into a sudden rage.
     Thought abnormalities, e.g. perseveration, delusions.
     Urinary and faecal incontinence may develop in later stages.
     Disorientation in time; disorientation in place and person may also develop in later stages.
     Neurological signs may or may not be present, depending on the underlying cause.
                     100
Causes of Dementia
Causes of Delirium
                                                                          101
Dementia
                                                         Core features
                                                           Memory impairment (amnesia), with
    Risk factors for non- familial Alzheimer’s disease
                                                          Other features
                                                            Depression
                                                            Psychosis
                                                            Behavioural symptoms
                                                            (e.g. agitation, wandering)
                                                            Personality change
                                                                                       103
                                          Lewy body
                                          Progressive disease involving
                                          abnormal deposits of a protein
                                          called alpha-synuclein in the brain
                                                   Q
  The swallow tail sign describes the normal axial imaging appearance of nigrosome-1
  within the substantia nigra on high-resolution T2*/SWI weighted MRI.
  Absence of the sign (absent swallow tail sign) is reported to have a diagnostic
  accuracy of greater than 90% for Parkinson disease and dementia with Lewy bodies
                                                                                          104
Parkinson’s Disease
   Parkinsonism is a clinical syndrome involving bradykinesia, plus at least one of
   the following three features: tremor, rigidity and postural instability.
    All patients with Parkinson's disease have parkinsonism, but not all patients with
   parkinsonism have Parkinson's disease.
Clinical features
 The presentation is usually asymmetrical, e.g. a resting tremor in an upper limb.
 Typical features of an established case include:
 Bradykinesia: Slowness in initiating or repeating movements, impaired fine
 movements (causing small handwriting) and expressionless face. The patient is slow to
 start walking, with reduced arm swing, rapid small steps and a tendency to run
 (festination).
 Tremor: Present at rest (4–6 Hz), diminished on action; it starts in the fingers/thumb
 and may affect arms, legs, feet, jaw and tongue.
 Rigidity: Cogwheel type mostly affects upper limbs; plastic (lead-pipe) type mostly
 affects legs.
 Non-motor symptoms may precede typical motor symptoms and include:
 ● Depression
 ● Anxiety
 ● Cognitive impairment
 Investigations
    Diagnosis is clinical.
    CT may be needed if any features suggest pyramidal, cerebellar or autonomic
    involvement, or if the diagnosis is in doubt, but is usually normal for age.
    Patients <50 yrs should be tested for Wilson’s disease and Huntington’s disease.
                                                          Mnemonics
       The cardinal triad of idiopathic
       Parkinson’s disease is                        T   Tremor at rest,
               a rest tremor,                        R   Rigidity,
             cog-wheel rigidity,                     A   Akinesia (or bradykinesia)
                bradykinesia.                        P   Postural instability.
                                                    105
                                           Mnemonics
                          Extrapyramidal side effects of anti- psychotic drugs
                            P - Parkinsonian syndrome
                            A - Akathisia      PAARTy Night
                            A - Acute dystonia
                            R - Rabbit syndrome
                            T - Tardive dyskinesia
                            N - Neuroleptic malignant syndrome
                                                                                                107
Delirium
 Delirium is characterised by
    1. A relatively acute onset,
    2. Clouding of consciousness, characterised by a decreased awareness of surroundings
    and a decreased ability to respond to environmental stimuli,
    3. Disorientation (time > place > person), associated with a decreased attention span and
    distractibility.
 Disturbance of sleep-wake cycle;( insomnia at night with daytime drowsiness)
 sun downing
    Diurnal variation is marked, usually with worsening of symptoms in the evening and night.
Predisposing Factors
 1. Pre-existing brain damage or dementia                    Previous Year Questions          NEET 2018
 2. Extremes of age (very old or very young)                                     Predicted Question
                                                                 A. Which of the following is in
 3. Previous history of delirium
                                                                 favour of delirium ?
 4. Alcohol or drug dependence
                                                               A. Occurs gradually
 5. Generalised or focal cerebral lesion
                                                    :
                                                               B. Fluctuating
 6. Chronic medical illness
                                                               C. Preserved consciousness
 7. Surgical procedure and postoperative period
                                                               D. Auditory hallucinations
 8. Severe psychological symptoms (such as fear)
  9. Treatment with psychotropic medicines
 10. Present or past history of head injury                                    Mnemonic
 11. Individual susceptibility to delirium                                    OCD CAMPS
Wernicke's encephalopathy.
   Acute neuropsychiatric condition due to an initially reversible biochemical brain
   lesion caused by depletion of vitamin B1 (thiamine).
 Causes
  • Chronic alcohol use
  • Protein-calorie malnutrition from malabsorption or forced/self-imposed inadequate diet
  • Patients with protracted vomiting
  • Carbohydrate loading (intravenous or oral) when thiamine stores are minimal
  • Chronic renal failure
  • Hyperalimentation, AIDS, and drug misuse
  • Genetic abnormality of transketolase enzyme
 Clinical Features
   • Mental disturbances:
      • Progressive depression of the state of consciousness.
      • Global confusional apathetic state, profound listlessness,
        inattentiveness and disorientation.
   • Paralysis of eye movements:
      • Vlth nerve palsy and diplopia.
      • Nystagmus.
      • Internuclear ophthalmoplegia.
   • Ataxia of gait-this affects stance and gait predominantly.
                                                                                            111
Management
 • Immediate administration of thiamine.
 • Magnesium is often required as it is a cofactor required for normal functioning of
 thiamine-dependent enzymes.
 • Intravenous glucose solutions should not be given particularly in malnourished
 patients, as they may exhaust the patient's reserve of B vitamins and either
 precipitates Wernicke's disease in a previously unaffected patient or cause a rapid
 worsening of an early form of the disease.
Korsakoff psychosis
   A late complication of persistent Wernicke encephalopathy and results in memory
   deficits, confusion, and behavioral changes.
   Korsakoff psychosis occurs in 80% of untreated patients with Wernicke encephalopathy.
   Korsakoff syndrome is often accompanied by Wernicke encephalopathy; this
   combination is called Wernicke–Korsakoff syndrome.
  Symptoms
    1 anterograde amnesia, memory loss for events after the onset of the syndrome
    2 retrograde amnesia, memory loss extends back for some time before the onset
        of the syndrome
    3 amnesia of fixation, also known as fixation amnesia (loss of immediate memory, a
        person being unable to remember events of the past few minutes)
    4 confabulation, that is, invented memories which are then taken as true, due to
        gaps in memory, with such gaps sometimes associated with blackouts
    5 minimal content in conversation
    6 lack of insight
    7 apathy – interest in things is quickly lost, and there is an indifference to change
              Mnemonics                                   Mnemonics
         Wernicke's encephalopathy.                     Korsakoff psychosis
     C   Confusion                                 R   Retrograde amnesia
     O   Ophthalmoplegia                           A   Anterograde amnesia
     A   Ataxia                                    C   Confabulation
     T   Thiamine deficiency                       K   Korsakoff’s psychosis
   Confabulation
   To fill in the memory gaps, the patient uses imaginary events in the early
   phase of illness.
                                                                                                       112
Catatonia
   A state of psycho-motor immobility and behavioural abnormality.
   Often associated with Schizophrenia
   Types- i. Catatonia with other medical disorders
         ii. Catatonia due to other medical disorders
         iii. Unspecific Catatonia
 Clinical features
                                        Symptoms
Stupor Excitment
w
                                Addiction Mechanism
A. Alpha (α)
                                                      B. Beta (β)
i. Excessive and inappropriate drinking to relieve
                                                      i. Excessive and inappropriate drinking.
physical and/or emotional pain.
                                                      ii. Physical complications (e.g. cirrhosis,
ii. No loss of control.
                                                      gastritis and neuritis) due to cultural
iii. Ability to abstain present.
                                                      drinking patterns and poor nutrition.
                                                      iii. No dependence.
C. Gamma (γ); malignant alcoholism
i. Progressivecourse.                                 D. Delta (δ)
ii. Physical dependence with tolerance and            i. Inability to abstain.
with- drawal symptoms.                                ii. Tolerance.
iii. Psychological dependence, with                   iii. Withdrawal symptoms.
inability to control drinking.                        iv. The amount of alcohol consumed can
                                                      be controled.
E. Epsilon (ε)                                        v. Social disruption is minimal.
i. Dipsomania (compulsive-drinking).
ii. Spree-drinking.
                          118
  Mnemonics
Alcohol intoxication
S -SPEECH SLURRED
A -ATTENTION IMPAIRMENT
M -MEMORY IMPAIRMENT
S -STUPOR OR COMA
G -GAIT UNSTEADY
I -INCOORDINATION
N -NYSTAGMUS
119
                                                                                                       120
Withdrawal Syndrome
1. Delirium tremens
  Delirium tremens (DTs) is a rapid onset of confusion usually caused by withdrawal from
  alcohol.
  When it occurs, it is often three days into the withdrawal symptoms and lasts for two to
  three days.
  Physical effects may include shaking, shivering, irregular heart rate, and sweating.
  People may also hallucinate.
   Occasionally, a very high body temperature or seizures may result in death.
 Symptoms
   nightmares,
                                              fever,
   agitation,
                                              high blood pressure,
   global confusion,
                                              heavy sweating,
   disorientation,
                                              other signs of autonomic hyperactivity
   visual and auditory hallucinations,
                                              (fast heart rate and high blood pressure).
   tactile hallucinations,
   These symptoms may appear suddenly but typically develop two to three days
   after the stopping of heavy drinking, being worst on the fourth or fifth day.
   These symptoms are characteristically worse at night
Treatment
  • Benzodiazepines- lorazepam (Ativan), diazepam (Valium), or chlordiazepoxide
    (Librium), which can effectively
  • Barbiturates, like phenobarbital
  • Antipsychotics, such as haloperidol (Haldol), may be used in low doses to help reduce
    problematic behaviors
CAGE questionnaire
Alcoholics Anonymous
                                                         Motivation cycle
                                                             Cycle of change
                                                         Prochaska & DiClemente
v. Psychosocial rehabilitation
                                                                                Q
                                                              Magnan's sign
                                    Followed by
       cocaine ‘runs’ (binges)                        cocaine ‘crashes’ (interruption of use).
treatment of overdose
    Oxygenation,                                                 Triphasic withdrawel
    Muscle relaxants,
    IV thiopentone and/or IV diazepam
    (for seizures and severe anxiety).
Treatment of Chronic Cocaine Use
        Bromocriptine (a dopaminergic agonist)
                                                  I
                                                      Reduce cocaine craving
        Amantadine (an antiparkinsonian)
        Supportive psychotherapy and
                                                      Prevention of relapse
        Contingent behaviour therapy
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                        Parenteral mode
    heroin
                        Smoked or ‘Chased’ (chasing the dragon)
                                                :
    Impure form          ‘smack’ or ‘brown sugar’ in India
     More addicting than morphine and can cause
     dependence even after a short period of exposure.
Acute Intoxication
   Apathy,                    Respiratory depression,
   Bradycardia,               Subnormal core body temperature,
   Hypotension,               Pin-point pupils.
   Later, delayed reflexes, thready pulse and coma may occur in case of a large overdose.
   In severe intoxication, mydriasis may occur due to hypoxia.
Withdrawal Syndrome
                                          Peaks
                                   within 24-72 hours
               Onset of symptoms
               within 12-24 hours
                                    ^                         Subside
                                                        within 7-10 days
         Lacrimation,                   Insomnia,
         Rhinorrhoea,                   Raised body temperature,
         Pupillary dilation,            Muscle cramps,
         Sweating,                      Generalised bodyache,
         Diarrhoea,                     Severe anxiety,
         Yawning,                       Piloerection,
         Tachycardia,                   Nausea and vomiting
         Mild hypertension,             Anorexia.
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laboratory tests
  1. Naloxone challenge test (to precipitate withdrawal symptoms).
  2. Urinary opioids testing:
      Radioimmunoassay (RIA),                 Gas-liquid chromatography (GLC),
      Free radical assay technique (FRAT), High pressure liquid chromatography (HPLC) or
      Thin layer chromatography (TLC),        Enzyme-multiplied immunoassay technique (EMIT).
                            Personality Disorders
                         and Miscellaneous Disorders
Personality types
                                                                            *o
    A psychopathology        a relentless drive for thinness or a
                             morbid fear of fatness
   A physiological
   symptomatology            Presence of medical signs and
                             symptoms resulting from starvation
  Binge-eating/ purging type: During the last 3 months, the individual is engaging in
  recurrent episodes of binge eating or purging behavior (i.e., self-induced vomiting or the
  misuse of laxatives, diuretics, or enemas).
 DSM-5 Diagnostic Criteria for Anorexia Nervosa
   A. Restriction of energy intake relative to requirements, leading to a significantly low body
   weight in the context of age, sex, developmental trajectory, and physical health.
   B. Intense fear of gaining weight or of becoming fat, or persistent behavior that interferes
   with weight gain, even though at a significantly low weight.
  C. Disturbance in the way in which one's body weight or shape is experienced, undue
  influence of body weight or shape on self-evaluation, or persistent lack of
  recognition of the seriousness of the current low body weight.
   B. Recurrent inappropriate compensatory behaviors in order to prevent weight gain, such as self-
   induced vomiting; misuse of laxatives, diuretics, or other medications; fasting; or excessive
   exercise.
   C. The binge eating and inappropriate compensatory behaviors both occur, on average, at least
   once a week for 3 months.
   D. Self-evaluation is unduly influenced by body shape and weight.
   E. The disturbance does not occur exclusively during episodes of anorexia nervosa.
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Predicted Question
                                Psychosexual and
                            gender identity disorders
                                      Sexual disorders
Homosexuality
SEXUAL DYSFUNCTIONS
normal human sexual response cycle
 1. Appetitive Phase: The phase before the actual sexual response cycle. This
 consists of sexual fantasies and a desire to have sexual activity.
 2. Excitement Phase: The first true phase of the cycle, which starts with physical
 stimulation and/or by appetitive phase.
 3. Plateau Phase: The intermediate phase just before actual orgasm, at the height of
 excitement.
 4. Orgasmic Phase: The phase with peak of sexual excitement followed by release of
 sexual tension, and rhythmic contractions of pelvic reproductive organs.
 5. Resolution Phase: A general sense of relaxation and well-being, after the slight
 clouding of consciousness during the orgasmic phase
 •
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             Phases                                      Dysfunction
           Desire or Appetitive                       Hypoactive sexual desire disorder
                  phase                               Sexual aversion disorder
  sed: Frigidity
                                            Orgasm         Q
                                          Shortest stage
Premature ejaculation
   Ejaculation before the completion of satisfactory sexual activity for both partners.
   In severe cases, it is characterised by ejaculation either before penile entry into
   vagina or soon after penetration.
               biological                           psychological
          (relatively uncommon)                (e.g. performance anxiety).
   Doc: SSRI
   Squeeze technique (Seman’s technique)
       Dual Sex therapy : Patient + Partner
PARAPHILIAS
(DISORDERS OF SEXUAL PREFERENCE)
 Fetishism
     The sexual arousal occurs either solely or predominantly with a nonliving
     object, which is usually intimately associated with the human body.
 Fetishistic Transvestism
     The person actually or in fantasy wears clothes of the opposite sex (cross-
     dressing) for sexual arousal. This disorder should be differentiated from
     dual-role transvestism and transexualism.
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Sexual Sadism
  The person (the ‘sadist’) is sexually aroused by physical and/or psychological
  humiliation, suffering or injury of the sexual partner (the ‘victim’).
Sexual Masochism
 Exhibitionism
  Persistent (or recurrent) and significant method of sexual arousal by
  the exposure of one’s genitalia to an unsuspecting stranger.
 Voyeurism
  Persistent or recurrent tendency to observe unsuspecting persons (usually
  of the other sex) naked, disrobing or engaged in sexual activity.
Frotteurism
 Persistent or recurrent involvement in the act of touching and rubbing against
 an unsuspecting, nonconsenting person (usually of the other sex).
Paedophilia
Zoophilia (Bestiality)
 Persistent and significant involvement in sexual activity with animals is
 rare.
Others
Sexual arousal with urine (urophilia); faeces (coprophilia); enemas
(klismaphilia); corpses (necrophilia),
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Dhat Syndrome
 Seen in sexually illiterate people.
 Belief that seminal discharge causes loss of energy, fatigue, somatic symptoms.
Koro Syndrome
 Fear of shrinking of male sex organs into the abdomen causing fear, depression.
Mental Retardation
 INTELLECTUAL DEVELOPMENT
    Sensori-Motor Stage
       Birth to 2 years of age
         i. Actions related to sucking, orality and assimilation of objects.
         ii. Ability to think of only one thought at a time.
         iii. Inanimate objects are given human qualities.
         iv. ‘Out of sight’ means ceasing to exist.
     Pre operational Stage
MENTAL RETARDATION
 Significantly sub-average general intellectual functioning, associated with
 significant deficit or impairment in adaptive functioning, which manifests during
 the developmental period (before 18 years of age).
                                            mental age
     Intelligence Quotient                                         × 100
                                          chronological age
Developmental delay
                  Developmental quotient (DQ)=
            developmental age/ chronological age x 100
Infantile autism
  Childhood onset autism or childhood onset pervasive developmental disorder.
  The onset occurs before the age of 2 1⁄2 years
Sex ratio Male > Female Male >> Female Females only Male > Female
Social skills           Very poor                Poor            Varies with age         Very poor
Communication
                       Usually poor              Fair              Very poor              Very poor
   skills
 Circumscribed           Variable               Marked                NA                     NA
     interest          (Mechanical)             (Facts)
                        Severe MR              Mild MR
    IQ range                                                       Severe MR               Severe MR
                        to normal              to normal
Rhett Syndrome
 - Associated with MECP2 gene in Chromosome X (so affects female more).
Childhood Disintegrative Psychosis (Heller Syndrome)
 - Bowel and Bladder disturbances present.
 3. Residual type:
      It is usually diagnosed in a patient in adulthood, with a past history of ADD
      and presence of a few residual features in adult life.
 4. Hyperkinetic disorder with conduct disorder (Hyperkinetic
 conduct disorder).
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Treatment
  Pharmacotherapy
  Stimulant medication:
                                                     Stimulation of the         Decreasing
     Dextroamphetamine
     methylphenidate      }   Act on the reticular
                              activating system
                                                     inhibitory influences on
                                                     the cerebral cortex
                                                                                hyperactivity and/or
                                                                                distractibility.
   In pre - school children, 4 methyl phenidate can cause sympathomimetic side effects like a raise
   in BP, tachycardia, insomnia and has abuse potential.
   Drugs like Atomocetine (SNRI) is preferred in such cases.
   Behaviour Modification
   Counselling and Supportive Psychotherapy
CONDUCT DISORDERS
 Characterised by a persistent and significant pattern of conduct, in which the
 basic rights of others are violated or rules of society are not followed.
  According to ICD-10, there are four subtypes of conduct disorder:
              1. Conduct disorder confined to the family context.
              2. Unsocialised conduct disorder.
              3. Socialised conduct disorder.
              4. Oppositional defiant disorder.
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€0
     For conduct disorder, >= 6 months of symptoms is required.
€0
     Symptoms must start at < 18 years ( after 18 years, it is anti social personality disorder)
€0
     Destructive, deceitful gang activities.
Oppositional Defiant Disorder
  Age < 10 years
     •
     Adoptive Trial
     •
      Birth parents, adoptive parents, adopted child.
     Encopresis
     •
      Soiling of clothes with feces (diagnosis at > 4 years of age).
     Enuresis
     •
      > 5 years of age.
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 TIC DISORDERS
  Tic is an abnormal involuntary movement (AIM) which occurs suddenly,
  repetitively, rapidly and is purposeless in nature.
                                                                                           Previous Year
Previous Year Questions                                                 INICET 20          Questions
                                                                                                            INICET 20
  Q A 7 year old child presented with history of bed wetting for last 1 year, at a
                                                                                              Q. Selective Mutism in
  frequency being twice a week. With thorough investigations, organic cause
                                                                                              children is indication of:
  is ruled out. What should be the initial treatment plan:
                                                                                              a. Childhood depression
  a. Pharmacotherapy with imipramine
                                                                                              b. Childhood anxiety
                                                                                              •
  b. Psychodynamic psychotherapy
                                                                                              c. Hyperkinetic disorder
  c. Bladder training with reward for delaying micturition in daytime
                                                                                              d. Childhood Psychosis
  d. Bell and pad based classical conditioning
  ✓
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Elimination Disorders
  Nocturnal enuresis
      Involuntary voiding at night after 5 yrs of age for more than 3 months
           Primary- Child has not yet had a prolonged period of dry
           Secondary- Child begins wetting after having stayed dry
   Epidemiology
             - 60% are boys
             - 50% have family history
     Treatment
          Rule out any organic causes
          1. Reassure parents. - Self limiting
                                      - Restrict fluid intake after 6pm
                                      - Child to void at bedtime
          2. Motivational therapy(initial measure)
                                     - Star chart with reward for delaying
          3. Conditioning therapy- Bell and pad alarm method.
                                           - 30%-60% success
                                           - Lower relapse rate than drugs
          4. Pharmacotherapy- with Oral Desmopressin at bedtime
          5. Combination of alarm & desmopressin- more effective
                           Psychiatric emergencies
Suicide
   Commonest cause of death among the psychiatric patients.
    Deliberate self-harm (DSH) and is defined as a human act of self-intentioned
    and self-inflicted cessation (death)
  1. A crisis that causes intense suffering with feelings of hopelessness and helplessness
  2. Conflict between unbearable stress and survival
  3. Narrowing of the person’s perceived options
  4. Wish to escape (it can often be an escape, rather than a going-towards)
  5. Often a wish to punish self and/or punish significant others with guilt
          Risk Factors for Suicide
Paradoxical suicide
      Patients recovering from suicidal depression are at high risk
      As the depression lifts, patient become energised and put their suicidal plan to action.
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                            Community psychiatry
MENTAL HEALTH ACTS IN INDIA
    Developed to protect the basic fundamental right of people “Right to live ” that
    comes under article 21 of constitution.
                                   MENTAL HEALTH ACTS IN INDIA
      PRE-INDEPENDENCE                                        POST-INDEPENDENCE
                                                                   1947:Indian Psychiatric
           1858:Indian Lunatic
                                                                   association established.
           assylum act of 1858
                                                                   1987:Mental Health act of
           1912:Indian Lunancy
                                                                   1987(indian psychiatric society)
           act of 1912
                                                                     Mental Health Care Bill
                                                                     proposed in 2013
(a) the way the person wishes to be cared for and treated for a mental illness;
(b) the way the person wishes not to be cared for and treated for a mental illness;
  (2) An advance directive may be made by a person irrespective of his past mental
  illness or treatment for the same.
  (3) An advance directive made shall be invoked only when such person ceases to
  have capacity to make mental healthcare or treatment decisions and shall remain
  effective until such person regains capacity to make mental healthcare or
  treatment decisions.
  (4) Any decision made by a person while he has the capacity to make mental
  healthcare and treatment decisions shall over-ride any previously written advance
  directive by such person.
  (5) Any advance directive made contrary to any law for the time being in force
  shall be ab initio void.
Independent Admission:
    Any person who considers himself to have mental illness and desires admission, who is not a
    minor
    Admitted if the Medical officer or Psychiatrist is satisfied that
             Mental illness of severity requiring admission
             Patient should benefit from admission and treatment
             Request made is under free will
             Has capacity to make mental health care decisions
             Informed consent
             Bound to rules and regulations of the establishment
    Limited to a period of 30 days •
    To be informed to MHRB within 7 days of admission
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Antidepressants
163
                                                           164
                                                           •
Drug of choice for resistant rheumatic chorea: Valproate
                                                 165
Risperidone
  “Off label” refers to using a drug for conditions not listed on the Food and Drug
  Administration (FDA) label of approved uses. Drugs are commonly prescribed off
  label when approved drugs cannot be used or do not work. Off-label uses may be
  supported by clinical evidence.
    • Dementia-related behavioral problems
    • Depression
    • Obsessive-compulsive disorder (OCD)
    • Post-traumatic stress disorder (PTSD)
    • Personality disorders
    • Tourette’s syndrome in children and adolescents
      S   Stomach upset
      S   Sexual dysfunction
      S   Serotonin syndrome
      S   Suicidal thoughts
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Serotonin syndrome
Manifestations
 Neuromuscular abnormalities                      Autonomic hyperactivity
    Hyperreflexia,                                    Tachycardia on admission,
    Inducible clonus,                                 Mydriasis, diaphoresis, and the
    Myoclonus,                                        Presence of bowel sounds and Diarrhea
    Ocular clonus,
    Spontaneous clonus,                           Mental status changes
    Peripheral hypertonicity,                         Agitation and delirium
    Shivering
    The onset of symptoms is usually rapid, with clinical findings often occurring within
    minutes after a change in medication or self-poisoning.
Treatment
   Stop drugs - usually resolves in no more than 24hrs
   Symptomatic measures- Cooling BDZS
Prevention
    Caution when combining or switching seratonergic antidepressants
                                                                                  Mnemonics
                                                                                Serotonin syndrome
                                                                               S Shivering
                                                                               H Hyperreflexia, myoclonus
                                                                               I Increased temperature
                                                                                 (>41C)
                                                                           S
                                                                               V Vital signs instability
                                                                           S
                                                                           S     (HR ,Rr ,BP )
                                                                           S   E Encephalopathy
                                                                                 (Altered LOC)
                                                                               R Restlessness
                                                                               S Sweating(Diaphoresis)
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psychosurgery
                               Papez circuit
  The aim of psychosurgery is to produce surgical lesions in carefully selected
  parts of limbic system and/or its connecting fibres.
  One major part of limbic system, believed to be important in emotional
  experiences, is Papez circuit.
  This important circuit, which lies within the limbic system, connects cingulate
  bundle, hippocampus, anterior thalamus, mammillary bodies, fornix and septum
 Indications
  1. Chronic, severe, incapacitating depression, which has not responded to all
  available treatments.
  2. Chronic, severe, incapacitating obsessive-compulsive disorder (OCD), which
  has not responded to all available treatments.
  3. Chronic, severe, incapacitating anxiety disorder, which has not responded to
  all available treatments.
  4. Schizophrenia with severe depressive component, which has not responded to
  all available treatments.
  5. Severe, pathological and uncontrolled aggressive behaviour associated with a
  psychiatric or neurological illness (e.g. temporal lobe epilepsy).
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 ELECTROCONVULSIVE THERAPY
   Electroconvulsive therapy (ECT) is a psychiatric treatment where a generalized
   seizure (without muscular convulsions) is electrically induced to manage refractory
   mental disorders.
 • A) According to technique:                      • B) According to placement of electrodes
     Direct ECT      Modified ECT                      Bilateral    Unilateral     Bifrontol
 Indications
   1. Major severe depression
       i. With suicidal risk (This is the first and mostimportant indication for ECT)
       ii. With stupor
       iii. With poor intake of food and fluids
       iv. With melancholia
       v. With psychotic features
       vi. With unsatisfactory response to drug therapy
       vii. Where drugs are contraindicated, or have
       serious side effects
       viii. Where speedier recovery is needed.
   2. Severe catatonia (non-organic)
       i. With stupor
       ii. With poor intake of food and fluids
       iii. With unsatisfactory response to drug therapy
       iv. Where drugs are contraindicated, or have serious side-effects.
       v. Where speedier recovery is needed.
  3. Severe psychoses (schizophrenia or mania)
        i. With risk of suicide, homicide or danger of physical assault
        ii. With unsatisfactory response to drug therapy
        iii. Where drugs are contraindicated, or have serious side effects
        iv. With very prominent depressive features (e.g. schizo-affective disorder).
Modified ECT
 • Electroconvulsive therapy is modified with the use of Anesthesia, muscle relaxation and oxygenation.
 • The use of anesthesia is necessary to allay anxiety and achieve the maximum effect.
 • It is used to modify the force of convulsion and to avoid complications like bone fractures.
 • Modified ECT is also used for the patients who are recovering from heart conditions.
                                                                                                Q
     A short acting Barbiturate, methohexial sodium (Brevital sodium) or Theopental (pentothal)
     and ultra short acting depolarizing agent succinylcholine are given intravenously.
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Other therapies
✗
   Eye movement desensitisation and reprocessing - Treatment of PTSD
   Dialectical behavioural therapy - Treatment of Borderline Personality Disorder
 : Light Therapy - Treatments of seasonal affective disorder
172