PHARMACOLOGY - TEST 2

BDS III, BCUR III, BANS I

BSc Physiotherapy III

Date : 4 August 2014

Time : 1 Hour
Marks : 60

STUDENT INFORMATION:

i) Fill in on the answer sheet your surname, initials and student number.
ii) Mark with  beneath the surname, initials and student number the
appropriate letter or number.

INSTRUCTIONS:

SECTION A:
Answer this section on the provided answer sheet (questions 1- 15). 15marks

SECTION B:
Answer this section on the same answer sheet (questions 16-30). 15 marks

SECTION C:
Answer this section on the same answer sheet (questions 31-40) 10 marks

SECTION D:
Answer this section on area provided (questions 41-50) 10 marks

SECTION E:
Answer this section on area provided (questions 51-60) 10 marks

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 INSTRUCTIONS
SECTION A

STUDENT INFORMATION:

i) Fill in on the answer sheet your surname, initials and student number.
ii) Select the correct answers by marking with  the appropriate letter or number.

ANSWERING THE QUESTIONS :

i) NOTE: One mark awarded for each correct answer and 0,5 mark subtracted for
each wrong answer.
ii) If the answer is true, mark column A. If the answer is false, mark column B.
iii) Each question corresponds to a similar number on the answer sheet.
iv) If both columns are marked, one mark will be subtracted.

e.g. Question Z:

Concerning drugs:

1. Theophylline is a beta-blocker
2. Atropine decreases mucus secretion

NOTE: REMEMBER TO MARK “A” TO INDICATE “TRUE”

AND “B” TO INDICATE “FALSE”

Answer Sheet:

A B C D E F
1.      
2.      

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SECTION A:

1. Theophylline has a narrow therapeutic index T

2. Inhaled corticosteroids and salbutamol combined can increase asthma attacks F
3. Short acting β2 agonists are recommended for quick relief of symptoms in asthma T
4. The treatment for status asthmaticus will include methylprednisone via IV T
5. Cimetidine can decrease the absorption of ketoconazole T
6. Proton pump inhibitors reduce acid by stimulation the H+/K+ ATPase proton pump F
7. Terbinafine is the antifungal of choice for deep systemic mycoses. F
8. Fluconazole is used for fungal meningitis. T
9. Metronidazole is a potent anti-fungal. F
10. Praziquantel increase permeability of cell membrane to calcium. T
11. It is safe to combine diltiazem with atenolol. F
12. Nitroglycerin can cause bradycardia. F
13. Digoxin is the mainstay of treatment of vascular constriction and fluid retention F
14. Nifedipine should not be given to a pregnant, hypertensive woman F
15. Carvedilol has α and β receptor blocking properties. T

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 INSTRUCTIONS
SECTION B

i) Choose the correct answer from the options under each question.

ii) No negative marking for this section.

iii) One mark will be awarded for each correct answer, no mark allocated for wrong or unanswered
questions.

iv) Each question corresponds to a similar number on the answer sheet.

EXAMPLE: Question X:

Which of the following are antibiotics:

1) Penicillin
2) Fanta
3) Coca Cola
4) Ampicillin
5) Tab

A = 1,2 B = 2,3 C = 3,4 D = 4,5 E = 1,4

Penicillin and ampicillin are antibiotics, therefore the correct answer is E.

Mark E on the answer sheet.

A B C D E

1.     

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SECTION B:

16. The following statements are true about chloroquine:

1. Drug of choice for P.falciparum, except in resistant strains
2. It is an allylamine drug
3. It has a low therapeutic index
4. Less effective against P.vivax
5. It is used in combination with ketoconazole

A = 1,3 B = 2,3 C = 2,5 #D = 1,4 E = All of the above

17. Nystatin is an antifungal drug with the following properties:

1. It binds ergosterol in fungal cell wall
2. It is not absorbed when taken orally
3. It is used for superficial candida infections
4. It is recommended for treatment of dermatophyte infections
5. It has serious systemic adverse effects

#A = 1,2,3 B = 1,3,5 C = 1,4,5 D = 2,3,4 E = 1,2,4

18. Terbinafine is an antifungal drug with the following properties:

1. It is effective against candida species
2. Its indications include oropharyngeal thrush
3. It accumulates in breast milk; therefore it is not for nursing mothers
4. Inhibits metabolism of tricyclic antidepressants and beta blockers
5. It is administered intravenously for cutaneous infections

A = 1,2 #B = 3,4 C = 2,5 D = 1,5 E = 4,5

19. Amphotericin B is an antifungal with the following properties:

1. It is not absorbed orally
2. Its indications include oropharyngeal thrush
3. It accumulates in breast milk; therefore it is not for nursing mothers
4. Inhibits metabolism of tricyclic antidepressants and beta blockers
5. It is a naturally occurring polygene macrolide antibiotic produced by Streptomyces nodosus

A = 1,2 B = 3,4 C = 2,5 #D = 1,5 E = 4,5

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20. The following drugs are short acting β2 agonists:

1. Salmeterol
2. Albuterol
3. Formeterol
4. Salbutamol
5. Terbutaline

A = 1,2,3 B =2,3,4 #C = 2,4,5 D = 3,4,5 E = All of the above

21. An adverse effect of inhaled corticosteroids:

1. Mucus secretion
2. Seizures
3. Oropharyngeal candidiasis
4. Bronchoconstriction
5. Bad taste in mouth

A = 1,2 B =2,3 C = 2,4 #D = 3,5 E = 1,4

22. Nasal decongestants include:

1. Loratadine
2. Phenylephrine
3. Cetirizine
4. Oxymetazoline
5. Cyclizine

A = 1,2 B =2,3 #C = 2,4 D = 3,5 E = 1,4

23. Effective cough treatments include:

1. Montelukast
2. Codeine
3. Ipratropium
4. Dextromethorphan
5. Theophylline

A = 1,2 B =2,3 #C = 2,4 D = 3,5 E = 1,4

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24. Nausea and vomiting can be treated with:

1. Prochlorpramide
2. Odansetron
3. Metoclopramide
4. Palonosetron
5. Loperamide

A=1 B =1,2 C = 1,2,3 #D = 1,2,3,4 E = All of the above

25. The following drugs are included in the triple therapy against Helicobacter pylori.

1. Omeprazole
2. Metronidazole
3. Aspirin
4. Bismuth subsalicylate
5. Clarithromycin

A = 1,2,3 B =2,3,4 C = 1,4,5 #D = 1,2,5 E = 2,4,5

26. Angiotensin converting enzyme inhibitors (ACEI’s):

1. Can cause angioedema
2. Are safe in pregnancy
3. Can cause cough as a side effect
4. Can increase bradykinin levels
5. Cannot be combined with diuretics

A = 1,2,3 B = 2,3,4 C = 3,4,5 #D = 1,3,4 E = 2,4,5

27. In which of the following conditions are  adrenergic blockers use therapeutically:
1. Myocardial infarction
2. Supraventricular tachycardia
3. Hypertension
4. Nasal decongestion
5. Migraine prophylaxis

A = 1,2,3 B = 1,2,3,4 C = 1,2,4 #D = 1,2,3,5 E = all of the above

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28. Which of the following is/are contra-indications for the use of
non-selective  blockers:
1. Patients with high plasma levels of cholesterol and triglycerides
2. Patients with bradycardia
3. Patients with elevated blood pressure
4. Diabetic patients
5. Patients with COPD

#A = 1,2,4,5 B = 1,2,3,4 C = 1, 3,4 D = 1,2,3,5 E = 1,3,5

29. Side effects of osmotic diuretics include:

1. Hypertension
2. Nausea and vomiting
3. Headache
4. Hyponatremia
5. Hypernatremia

A = 1,2,4 #B = 2,3,4 C = 1, 3,4 D = 2,3,5 E = 1,3,5

30. The following drug is a calcium channel blocker.

1. Verapamil
2. Prazocin
3. Methyldopa
4. Hydralazine
5. Atenolol

#A = 1 B=2 C=3 D=4 E =5

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 INSTRUCTIONS
SECTION C

STUDENT INFORMATION:

i) Fill in on the answer sheet your surname, initials and student number.
ii) Mark with  beneath the surname, initials and student number the
appropriate letter or number.

ANSWERING THE QUESTIONS :

i) NOTE: One mark awarded for each correct answer

ii) Match the best answer from the choices provided for each set of questions as indicated.
Answers may
be repeated, or not used at all.
iii) Each question corresponds to a similar number on the answer sheet.

e.g.

A. Coke D. Beer
B. Water E. Milk
C. Tea F. Brandy

1. contains carbonated water and caffeine A

2. contains saturated fats E
3. contains between 5-10% alcohol D
4. contains tannins C
5. is derived from fermented yeast D
6. is a molecule made of 2 hydrogen atoms and 1 oxygen atom B

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SECTION C:
Match the drug with the correct group name.
A. Calcium carbonate
B. Lansoprazole
C. Montelukast
D. Ipratropium
E. Prednisone
F. Cimetidine

31. Cholinergic antagonist D

32. Anti-leukotriene drug C
33. Corticosteroid E
34. Proton pump inhibitor B
35. H2 histamine receptor blocker F
36. Antacid A

Match the following drugs with the infections they treat below:
A. Thiabendazole
B. Praziquantel
C. Co-trimoxazole
D. Amphotericin B

Infections:
37. Toxoplasmosis C
38. Leishmaniasis D
39. Filariasis A
40. Schistosomiasis B

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 INSTRUCTIONS
SECTION D

STUDENT INFORMATION:

i) Fill in on the sheet provided your course, name, initials and student number.

ANSWERING THE QUESTIONS:

i) Answer the questions by writing the correct single word, term or name in the space
provided.

ii) NOTE: No negative marking.

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MEMO

SECTION D:

Course: BDS III, BCUR III, BANS I , BSC PHYS III TEST 2
Date: 4 August 2014

41. Name (8) considerations to take into account before writing a prescription for a patient. (4)

1. Age of the patient (special care in elderly and peads)

2. Disease contra indications
3. Medicine interactions
4. Patient allergies
5. Drug-dietary interactions
6. Medicine with black box warnings
7. Pregnancy and breastfeeding
8. Co-existing patients conditions
9. Concomitant treatment by different physicians
Any 8

42. Describe the mechanism of action of Mebendazole, a drug effective against single or mixed
helminthic intestinal infections (roundworm, hookworm, pinworm, and whipworm) (2)

Acts by binding to and interfering with the assembly of the parasite’s microtubules and
also by decreasing glucose uptake

43. Malignant hyperthermia caused by halothane or succinylcholine can be treated with? (1)
Dantrolene
44. Name two (2) inotropic agents used in heart failure. (2)
Amrinone, Digitoxin, Digoxin, Dobutamine, Milrinone.
45. What is the most important to know about a drug in your opinion? (1)
Dosage, side effects, drug interactions, contraindications.

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 INSTRUCTIONS
SECTION E

STUDENT INFORMATION:

i) Fill in on the sheet provided your course, name, initials and student number.

ANSWERING THE QUESTIONS:

i) Answer the questions by writing the correct single word, term or name in the space
provided.

ii) NOTE: No negative marking.

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MEMO

SECTION E:

Course: BDS III, BCUR III, BANS I , BSC PHYS III TEST 2
Date: 4 August 2014

Case study:
51. A patient is admitted with an anaphylactic shock at the emergency ward.
a. Which drug will be the first drug you will administer? (1)
Adrenaline
b. Which receptors are involved and will be stimulated? (3)
α or α1, β1 and β2
c. Which two effects on the body caused by anaphylactic shock can cause death? (2)
Cardiovascular collapse, bronchoconstriction
d. Name two other drug groups that can also be given to assist. (2)
Corticosteroids, Antihistamines, Beta 2 agonists
e. How will you treat an anaphylactic/allergic reaction and what is the difference from (2)

anaphylactic shock

With antihistamines.
It is not life threatening can be itching, swelling, red eyes etc. Will not cause respiratory
constriction or other effects.

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