Appendix 1: Syndrome-Specific
Growth Charts
Figure A1.1 Height centiles for girls with untreated Turner syndrome aged 1–20 years. The gray-shaded area represents the 3rd to
97th centiles for normal girls. Pubertal staging is for normal girls. Adapted from Lyon A, Preece M, Grant D. Growth curves for girls with
Turner syndrome. Arch Dis Child 1985; 60: 932–5.
238
Appendix 1: Syndrome-Specific Growth Charts
Figure A1.2 Height and weight centiles
for boys with trisomy 21 syndrome aged
3–36 months. Adapted from Cronk
C, Crocker A, Peushel S et al. Growth
charts for children with Down syndrome.
Pediatrics 1988; 81: 102–10.
239
A P P E N D I X 1: S Y NDR OME- S PE CI F I C GR OWT H CH ARTS
Figure A1.3 Height and weight centiles
for boys with trisomy 21 syndrome
aged 2–18 years. The gray-shaded areas
represent the comparable values for the
3rd to 97th centiles for normal children.
Adapted from Cronk C, Crocker A,
Peuschel S et al. Growth charts for children
with Down syndrome. Pediatrics 1988;
81: 102–10.
240
Appendix 1: Syndrome-Specific Growth Charts
Figure A1.4 Height and weight centiles
for girls with trisomy 21 syndrome aged
3–36 months. Adapted from Cronk C,
Crocker A, Peuschel S et al. Growth
charts for children with Down syndrome.
Pediatrics 1988; 81: 102–10.
241
A P P E N D I X 1: S Y NDR OME- S PE CI F I C GR OWT H CH ARTS
Figure A1.5 Height and weight centiles
for girls with trisomy 21 syndrome aged 2–
18 years. The gray-shaded areas represent
the comparable values for the 3rd to 97th
centiles for normal children. Adapted from
Cronk C, Crocker A, Peuschel S et al.
Growth charts for children with Down
syndrome. Pediatrics 1988; 81: 102–10.
242
Appendix 1: Syndrome-Specific Growth Charts
Figure A1.6 Height centiles for boys with Noonan syndrome Figure A1.7 Height centiles for girls with Noonan syndrome
aged 0–18 years compared with normal values (dashed lines). aged 0–18 years compared with normal values (dashed lines).
The data were obtained from 64 Noonan syndrome males in a The data were obtained from 48 Noonan syndrome females in a
collaborative retrospective review. Adapted from Witt D, Keena B, collaborative retrospective review. Adapted from Witt D, Keena B,
Hall J et al. Growth curves for height in Noonan syndrome. Clin Hall J et al. Growth curves for height in Noonan syndrome. Clin
Genet 1986; 30: 150–3. Genet 1986; 30: 150–3.
243
A P P E N D I X 1: S Y NDR OME- S PE CI F I C GR OWT H CH ARTS
Figure A1.8 Height centiles for boys with Silver–Russell Figure A1.9 Height centiles for girls with Silver–Russell
syndrome. The gray-shaded area indicates normal boys ⫾2 syndrome. The gray-shaded area indicates normal girls ⫾2
standard deviations (SD). Adapted from Wollman H, Kirchner T, standard deviations (SD). Adapted from Wollman H, Kirchner T,
Enders H et al. Growth and symptoms in Silver–Russell syndrome: Enders H et al. Growth and symptoms in Silver–Russell syndrome:
review on the basis of 386 patients. Eur J pediatr 1995; 154: review on the basis of 386 patients. Eur J pediatr 1995; 154:
958–68. 958–68.
244
Appendix 1: Syndrome-Specific Growth Charts
Figure A1.10 Height centiles for boys with achondroplasia Figure A1.11 Head circumference centiles for boys with
(mean ⫾2 SD) compared with normal standard curves (dashed achondroplasia compared with normal curves (dashed lines).
lines). Data derived from 189 males. Adapted from Horton Data derived from 114 males. Adapted from Horton W, Rotter
W, Rotter J, Rimoin D et al. Standard growth curves for J, Rimoin D et al. Standard gowth curves for achondroplasia. J
achondroplasia. J Pediatr 1978; 93: 435–8. Pediatr 1978; 93: 435–8.
245
A P P E N D I X 1: S Y NDR OME- S PE CI F I C GR OWT H CH ARTS
Figure A1.12 Height centiles for girls with achondroplasia Figure A1.13 Head circumference centiles for girls with
(mean ⫾2 SD) compared with normal standard curves (dashed achondroplasia compared with normal curves (dashed lines). Data
lines). Data derived from 214 females. Adapted from Horton W, derived from 145 females. Adapted from Horton W, Rotter J,
Rotter J, Rimoin D et al. Standard growth curves for Rimoin D et al. Standard growth curves for achondroplasia.
achondroplasia. J Pediatr 1978; 93: 435–8. J Pediatr 1978; 93: 435–8.
246
Appendix 1: Syndrome-Specific Growth Charts
Figure A1.14 Linear growth in hypocondroplasic boys (solid
line). Adapted from Appan S, Laurent S, Champan M et al.
Growth and growth hormone therapy in hypochondroplasia.
Acta paediatr Scand 1990; 79: 796–803.
Figure A1.15 Linear growth in hypocondroplasic girls (solid
line). Adapted from Appan S, Laurent S, Champan M et al.
Growth and growth hormone therapy in hypochondroplasia.
Acta paediatr Scand 1990; 79: 796–803.
247
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Figure A1.16 Standardized curves for
height in Prader–Willi syndrome (PWS)
in male patients (solid line) and healthy
individuals (broken line). Adapted from
Butler MG, Brunschwig A, Miller LK et al.
Standards for selected anthropometric
measurements in Prader–Willi syndrome.
Pediatrics 1991; 88: 853–60.
Figure A1.17 Standardized curves for
height in Prader–Willi syndrome (PWS) in
female patients (solid line) and healthy
individuals (broken line). Adapted from
Butler MG, Brunschwig A, Miller LK et al.
Standards for selected anthropometric
measurements in Prader–Willi syndrome.
Pediatrics 1991; 88: 853–60.
248
Appendix 1: Syndrome-Specific Growth Charts
Figure A1.18 Standardized curves for
weight in Prader–Willi syndrome (PWS)
in male patients (solid line) and healthy
individuals (broken line). Adapted from
Butler MG, Brunschwig A, Miller LK et al.
Standards for selected anthropometric
measurements in Prader–Willi syndrome.
Pediatrics 1991; 88: 853–60.
Figure A1.19 Standardized curves for
weight in Prader–Willi syndrome (PWS)
in female patients (solid line) and healthy
individuals (broken line). Adapted from
Butler MG, Brunschwig A, Miller LK et al.
Standards for selected anthropometric
measurements in Prader–Willi syndrome.
Pediatrics 1991; 88: 853–60.
249
