RRL

DATE:
February 29, 2023 (Thursday)
ENTRIES:
This study assessed the efficacy and safety of ketoprofen patch compared with
placebo in patients who had rheumatoid arthritis and persistent wrist pain. Patients
(N = 676) who had achieved systemic disease control with a disease-modifying
antirheumatic drug and/or systemic corticosteroid, but still had persistent wrist
pain, were randomized to a 2-week course of once-daily treatment with application
of a 20-mg ketoprofen patch or a placebo patch to the wrist. The primary efficacy
end point was the percent change from baseline to the end of treatment in the
intensity of wrist pain scored by each patient on a 100-mm visual analog scale. The
mean ± SD percent change on the pain intensity scale was significantly larger in
patients treated with ketoprofen than in those receiving placebo (31.2% ± 30.3%
[95% confidence interval: 28.0–34.4] vs 25.5% ± 31.2% [95% confidence interval:
22.1–28.8]; P = .020). However, the actual difference of the mean pain intensity
scale between the 2 groups was small at the end of treatment. The frequency of
adverse events was similar in both groups. The ketoprofen patch was more effective
than placebo for relieving persistent local joint pain in patients with rheumatoid
arthritis. The patch was also safe and well tolerated during the 2-week treatment
period.
SOURCE/REFERENCE:

Kawai, S., Uchida, E., Kondo, M., Ohno, S., Obata, J., Nawata, Y., ... & Nagaya, I. (2010). Efficacy
and Safety of Ketoprofen Patch in Patients With Rheumatoid Arthritis: A Randomized, Double‐
Blind, Placebo‐Controlled Study. The Journal of Clinical Pharmacology, 50(10), 1171-1179.
DATE:
February 29, 2023 (Thursday)
ENTRIES:

Arthritis is a common condition that affects millions of people in India. It is characterized

by inflammation and pain in the joints, which can make it difficult to perform daily
activities. While there is no cure for arthritis, there are ways to manage the symptoms
and improve joint health. One of the ways to do this is by making dietary changes, and
rice can play a significant role in managing inflammation and joint health. Rice is a
staple food in India and is consumed in large quantities. It is a rich source of
carbohydrates, which provide energy to the body. However, not all types of rice are
created equal when it comes to managing arthritis. White rice, for example, is highly
processed and lacks the nutrients that are essential for joint health. On the other hand,
brown rice is a whole grain that is rich in fiber, vitamins, and minerals. It is also a good
source of antioxidants, which can help reduce inflammation in the body. In conclusion,
rice can play a significant role in managing inflammation and joint health. However, it is
essential to choose the right type of rice and incorporate it into a balanced diet.

SOURCE/REFERENCE:

Srinivas, G. (2023, July 4). Rice and Arthritis: Managing Inflammation and Joint
Health. FITPAA. https://www.fitpaa.com/blog/rice-and-arthritis-managing-
inflammation-and-joint-health/#
DATE:
February 29, 2023 (Thursday)
ENTRIES:
Since time immemorial, people had been using herbal medicines. With the advent
of modern medicine and the development of new drugs, people had switched to the
use of commercial medicines. These medicines had beenmanufactured from the
flora and fauna that abound.However, the availability and abundance of some of
these sources had declined due to some natural and anthropogenicfactors like
deforestation. So, in developing a new medicine, the abundance of the plant or the
animal from where it is extracted should be considered. In addition to this, there are
still a lot of people who rely on alternative medicine because of the escalating
prices of medicine. In the Philippines, many people still resort to herbal medicine. In
the ancient and medieval times, almost all medicines came from plants. Plants were
used to ease pain, heal wounds and cure fever. Today, a lot of people still rely on
medicinal plants to meet the medicinal needs of a population (Fuller,1970).The
Philippines is endowed with many different flora and fauna which have medicinal
potentials. In the Philippines, specifically in Ilocos Sur, a plant called makahiya,
having a scientific name of Mimosa pudica Linn. Is very common and abundant. This
plant is just regarded as a menace in gardens, hence being uprooted and discarded.
Makahiya thrives in any kind of soil even without receiving special care. When the
plant is still young, its stem is erect but as the plant grows with age, the stem
becomes creeping or trailing. The stem is slender, branching and sparsely to
densely prickly, growing to a length of 1.5 meter. The leaves are bipinnately
compound, with one or two pinnae pairs having 10-26leaflets per pinna. The
petioles are also prickly. Pediculate(stalked) pale pink or purple flower heads arise
from the leafaxils. The globes are 8-10 mm in diameter (excluding testaments). On
close examination, it is seen that the floret petals are red in their upper part and the
filaments are pink to lavender. The fruits consist of 2-8 pods from 1-2 cm long each.
The flowers are pollinated by the wind and insects. Since this plant is very common
in the researcher’s area, this aroused her interest to make a study on the
medicinal prospects of this plant. Hence, in this study, the phytochemical screening
and the antimicrobial propertieswere conducted in the hope that the initial findings
of this study will serve as a basis for future investigations on the medicinal
prospects of this plant makahiya and for the discovery of new therapeutic agents
from this plant.
SOURCE/REFERENCE:

Acio, M. (2022, April 3). The Medicinal Prospects of Makahiya (Mimosa Pudica Linn) Plant.
www.academia.edu.
https://www.academia.edu/75369238/The_Medicinal_Prospects_of_Makahiya_Mimosa_Pudica_Linn_P
lant

DATE:
February 29, 2023 (Thursday)
ENTRIES:

The skin is the largest organ in the human body by mass, with an area of
between 1.5 and 2.0 m2 in adults. Drugs have been applied to the skin to
treat superficial disorders, for the transdermal administration of therapeutics
to manage systemic ailments and as cosmetics, dating back to the oldest
existing medical records of man. For instance, the use of salves, ointments,
potions and even patches, consisting of plant, animal or mineral extracts,
was already popular in ancient Egypt and in Babylonian medicine (around
3000 BC) (Magner, 2005; Geller, 2010). However, the routine use of
transdermal delivery systems only became a common practice in the latter
third of the 20th century when delivery technology was developed to enable
precise and reproducible administration through the skin for systemic effects.
The goal of this review is to detail the rich history of topical and transdermal
delivery that has evolved over thousands of years, focusing particularly on
the evolution and current use of transdermal patches. The potential efficacy
and suitability of this technology for systemic therapy is normally determined
by drug blood level–time profiles, which can be compared to or predicted
from p.o. or parenteral administration. These drug concentrations in the
blood are, in turn, defined by the amount of drug released into the body from
the delivery system and the application area. Transdermal delivery is also
used to produce clinical effects, such as local anaesthesia and anti-
inflammatory activity, deep within or beneath the skin. In contrast, topical
delivery seeks to treat superficial, although at times very serious, skin
problems through a relatively local action.
SOURCE/REFERENCE:

Pastore, Michael N., et al. "Transdermal patches: history, development

and pharmacology." British journal of pharmacology 172.9 (2015):
2179-2209.
DATE:
February 29, 2023 (Thursday)
ENTRIES:
Mimosa pudica Linn, known as “makahiya” in Filipino, and “Babain” in Iloko is a
popular ornamental plant, as its leaves fold up when stimulated by touch, heat or
wind. The seeds and other parts of the Mimosa pudica Linn plant contain mimosine,
and extracts of the plant have been shown in scientific trials to be a moderate
diuretic, can depress duodenal contractions similar to atrophine sulphone, can
promote regeneration of nerves, and reduce menorrhagia. The roots and leaves are
commonly used in treatment. The roots are bitter, astringent, acrid, cooling,
vulnerary, alexipharmic, resolvent, diuretic, antispasmodic, emetic, constipating,
and febrifuge. They are useful in vitiated conditions of pitta, leucoderma,
vaginopathy, metropathy, ulcers, dysentery, inflammations, burning sensation,
hemorrhoids, jaundice, asthma, fistula, small pox, strangury, spasmodic, affections
and fevers (Pande and Pathak, 2010). Root extracts are reported to be a strong
emetic. Decoction or infusion of leaves is used in asthma, expectorant, urinary
complaints, glandular swelling, sore throat and hoarseness (Estrella, 1983). Some
studies indicate that the roots are in homeopathic treatments for many illnesses
such as urinary and vaginal infections, asthma, inflammations, and diarrhea, skin
rash, neurological disorders, and the symptoms of rheumatoid arthritis (Miley, n.d.).
Studies on the therapeutic effects of the roots of Mimosa pudica Linn are being done
in China, India, Trinidad, Panama, Haiti, Venezuela and other Southeast.
SOURCE/REFERENCE:

Balag-ey, Winston D., and Leonora E. Ngilangil. "Roots of Mimosa pudica Linn
“Makahiya” as an alternative treatment against urinary tract infections."

DATE:
February 29, 2023 (Thursday)
ENTRIES:
Mimosa belongs to the taxonomic group Magnoliopsida and family Mimosaseae.
In Latin it is called as Mimosa pudicaLinn. Ayurveda has declared that its root
is bitter, acrid, cooling, vulnerary, alexipharmic. It is used in the treatment of
leprosy, dysentery, vaginal and uterine complaints, and inflammations, burning
sensation, asthma, leucoderma, fatigue and blood diseases. Decoction of root is
used as gargle to reduce toothache. It is very useful in diarrhea (athisaara),
amoebic dysentery (raktaatisaara), bleeding piles and urinary infections. This
review gives a brief compilation of its phytochemical and pharmacological
activities. Nature has been a source of medicinal agents for thousands of years.
Various medicinal plants have been used for years in daily life to treat disease
all over the world. [1] Herbal medicine is based on the premise that plants
contain natural substances that can promote health and alleviate illness. [2-3]
The most important of These biologically active constituents of plants are
alkaloids, flavonoids, tannins and phenolic compounds. [4] There are many
herbs, which are predominantly used to treat cardiovascular problems, liver
disorders, central nervous system, digestive and metabolic disorders. The
Mimosa pudica, invites attention of the researchers worldwide for its
pharmacological activities such as antidiabetic, antitoxin, antihepatotoxin,
antioxidant and wound healing activities. It is reported to contain alkaloid,
glycoside, flavonoid and tannis. It is used in suppresses kapha and pitta heals
wounds, coagulates blood and sexual weakness. [5] All parts of the tree are
considered to possess medicinal properties and used in the treatment of
biliousness, leprosy, dysentery, vaginal and uterine complaints, inflammations,
burning sensation, fatigue, asthma, leucoderma, blood diseases.
SOURCE/REFERENCE:

Baby Joseph., Jency George, Jeevitha Mohan, (2013). Pharmacology and Traditional Uses of
Mimosa pudica.
https://www.researchgate.net/publication/288261991_Pharmacology_and_Traditional_Uses_of
_Mimosa_pudica .