Cerebellum Anatomy
Cerebellum Anatomy
ANATOMY
    Transverse dissection
    diagram :-                                            Revision capsule/PYQs:-
                                                            •• Roof is formed by skin, superficial fascia,
                                                               deep fascia
                                                            •• Floor is formed by muscles, bone
                                                            •• Contents of any space: - neuromuscular
                                                               bundle (VAN)
                                                          Q. Neurovascular bundle is absent in which
                                                             compartment of leg? [AllMS MAY 18]
1. Anterior
                                                             2. Lateral
    Vein – thin walled & collapsing                          3. Superficial posterior
    Artery – thick walled & recoil
                                                             4. Deep posterior
    Nerve – no lumen, solid cord
                                                          Q. Neurovascular bundle in abdomen runs in
       •• All neurovascular bundle of our body     have      between? (DEC FMGE 21)
          sequence as vein-artery-nerve except -
                                                             1.   Between external & internal oblique
          –– 1st Intercostal space
          –– Popliteal fossa                                 2. Between external oblique & transversus
                                                                abdominis
       •• HILTON’S LAW: - Hilton observed that
          nerves supplying the MUSCLE also innervate         3. Between internal oblique & transversus
          the SKIN overlying the muscle and the JOINT           abdominis
          over which that muscle acts.
                                                             4. Between transversus abdominis & fascia
                                                                transversalis
Anatomical position
                                                          PYQs:-
                                                             Frontal plane section is termed as? (DEC
                                                             FMGE 2021)
                                                             1.   Sagittal Section
                                                             2. Coronal Section
                                                             3. Horizontal Section
                                                             4. Oblique Section
                                             JOINTS
TYPES
                                                       B. Syndesmosis
Not movable                                            2 bones are connected via Ligaments.
Present in skull bones - fibrous tissue in between 2   E.g. - Middle Radio-Ulnar joint, Middle Tibio-fibular
bones.                                                 Interosseous Membrane, Inferior Tibio-fibular joint.
Types of Fibrous joint (Mnemonic - SaSu G)
                                                       C. Gomphosis
Sa - Sutures
                                                       Joint found in Gums.
Su - Syndesmosis
G - Gomphosis                                          2. Cartilaginous joints
A. Sutures                                             A. Primary Cartilaginous/Synostosis/Synchondrosis-
                                                                F. Pivot joint
                                                                → Rotatory movements between bones around an axis.
                                                                Atlanto-axial joint → between C1 and C2 (No movement
                                                                - Below atlas)
                                                                Superior (via annular ligament) and Inferior Radio-
    A. Ball and socket joint (Mnemonic - SHIP)                  ulnar joint
•• Movements at a joint:-
   –– Muscle only help to movement of joints when
      it’s crossing 2 joints
   –– If any Muscle crossing joint from front can
      make forward movement & if crossing from
      back can perform backwards movement
•• Gliding:-
   –– Flat surfaces of two bones glide across each
      other Gliding occurs between
       Carpals
2
    Anatomy
 Circumpennate
                                                       3. Cruciate:-
                                                       Which crossing each other, ex:- Sternocleidomastoid,
                                                       masseter (strongest muscle of body)
2. Oblique muscle :-
                                                       4. Twisted / spiral :- pectoralis major
    –– Pennate
                                                       (NEET 18)
        Unipennate :- 1st & 2nd lumbrical , Palmar
          interosseous
4
    Anatomy
    PYQs:
    Q. What is the function of the lumbricals at the
       metacarpophalangeal joint? (NEET PG 2018)
       A. Flexion 			
       B. Extension
       C. Adduction
       D. Abduction
    Q. What is the nerve supply of the first lumbrical?
       (INI-CET 2022 Pattern)
       A. Radial nerve 		
       B. Median nerve
       C. Ulnar nerve
       D. Musculocutaneous nerve
    Q. Action performed by marked muscle? (June
       FMGE 2022)
       A. Abduction of shoulder joint
       B. Adduction of shoulder joint		
       C. Protraction of scapula
       D. Retraction of scapula
                              PECTORAL REGION
Bones of pectoral region:-                               •• Clavicle is the only bone which pierced by the
                                                            nerve – Intermediate supraclavicular nerve
Clavicle:-
  •• It is aka collarbone / beauty bone / key bone
                                                       Scapula:-
                                                         •• Coracoid process fits in infra clavicular groove
  •• Clavicle parts:- medial 2/3rd & lateral 1/3rd (
                                                            / fossa aka delto- pectoral groove
     Mc fracture location) < Medial 3/5th & Lateral
     2/5th                                               •• Above the spine of Scapula there is supraspinous
                                                            Fossa & below infraspinous Fossa.
  •• Clavicle is the only bone having 2 ossification
     center
2
     Anatomy
Brachial Plexus
Parts of brachial plexus - (Ramu Tailor Drinks Cold       Thickest cord of Brachial Plexus - Posterior cord
Beer)/ RTDCB
                                                          Thickest nerve of Brachial Plexus - Radial nerve
Roots - Part of nerve attached to the spinal cord. 5 in
                                                          About cords -
number → C5-C8 and T1.
                                                          All posterior divisions unite to form → Posterior Cord
Trunk - 3 in numbers → Upper, Middle & Lower Trunk.
                                                          (Radial nerve)
Divisions - 1 anterior and 1 posterior from each Trunk.
                                                          Anterior divisions of Upper and Middle trunks →
Cords - 3 in number → Medial, Lateral & Posterior         Lateral Cord (Median nerve)
Cord (named according to the anatomical relation with
                                                          Anterior divisions of Lower trunk → Medial Cord
axillary artery).
                                                          (Ulnar nerve)
Note - Sometime contribution from other segments
also present:                                             (Note - In bracket - Main continuation of respective
    •• C4 - Pre-fixed brachial plexus                     Cords)
  •• Extended elbow - defect in Coracobrachialis,          •• Nerves with all root values in brachial plexus:
     Biceps, Brachioradialis.
Aka Waiter’s/Porter’s Tip hand OR Policeman’s Tip        UPDATES: GRAY’S 42nd UPDATE
hand.
                                                         Q. Root value of Ulnar nerve?
B. KLUMPKE’s Paralysis
                                                            A. C5,6,7
Causes -
                                                            B. C6,7,8
  •• Overstretching of Arm/Axillary area.
  •• Pulling of hand during delivery.                       C. C7,8 T1
Defects - D. C7,8
                                                    Triangle of Auscultation -
                                                    Less muscles - easily get LUNGS sounds
                                                      •• Lateral border - medial border of Scapula
                                                      •• Medial border - Trapezius
                                                      •• Base - Latissimus dorsi
Dissection / Surgery :
Superficial to deep
Skin → Superficial fascia → Deep fascia → Muscles
→ Bones
Muscles:-
1. Trapezius - by XI / Accessory spinal
nerve
   •• Shrugging of shoulder → Upper fibres
   •• Retraction of scapula → Middle fibres
   •• Overhead abduction → Lower fibres
2
     Anatomy
Skin → Superficial fascia → Deep fascia → Muscles     Rotator Cuff (SITS) - Supraspinatus, Infraspinatus,
                                                           				             Teres minor & Subscapularis.
Muscles
  •• Nerve supply of deltoid : Axillary nerve           •• Muscle most commonly damaged in Rotator
     (related to Surgical neck of Humerus)                 Cuff injury - supraspinatus
  •• Teres Minor - supplied by nerve to teres minor
     (branch of Axillary Nerve → Pseudoganglion
     present).
  •• Teres Major - by Lower Subscapular nerve.
2
      Anatomy
Uses -
                                                               D. Deltoid muscle
    Revision Capsule:
    Deltoid & Shoulder abduction:                         Q. 0 to 15 degree of abduction of joint is caused
                                                             by? (CONTROVERSIAL QUESTION: AIIMS
    Deltoid is supplied by:
                                                             NOV 17)
    Another muscle supplied by axillary nerve:
                                                               A. Supraspinatus
    Characteristic Of nerve to Teres minor is:
                                                               B. Infraspinatus
    Nerve supply Of Teres major:
    Rotator / Musculo - tendinous cuff is formed by:           C. Deltoid
                                                                                               - 0-90 degree
                                                                                               Abduction
                                                                                               weakness
                                                                                               - Loss of
                                                                                               rounded
                                                                                               contour of
                                                                                               shoulder
                                                                                               - medially
                                                                                               rotated arm
                                                      Radial     Radial groove    Extensors    Wrist drop
                                                                                  of Upper
                                                                                  limb
                                                      Ulnar      Medial           Small        Ulnar/Partial
                                                                 epicondyle       muscles of   Claw hand
                                                                                  hand
                                                      Median     Supracondylar Flexors of      - Median Claw
                                                                 Area          Wrist           hand
                                                                                               - Benediction
                                                                                               hand
                                                                                               deformity
ORTHO-RADIO-ANAT INTEGRATION:
Humerus connected to 4 nerves
2
     Anatomy
    Revision Capsule:
       •• Cadaveric images
       •• Nerve supply of BBC:
       •• Clinical integration With Radio & Ortho
    PYQs
    Q. A patient visited to trauma & casualty ward with
       multiple fracture of shaft Of humerus. He was
       having the difficulty in elbow flexion & supination.
       He also complained about loss of sensation Over
       lateral side of forearm. nerve is most probably           A. A
       damaged? (NEET PG 2021)
                                                                 B. B
        A. Musculocutaneous nerve
                                                                 C. C
        B. Median nerve
C. Ulnar nerve D. D
        D. Radial nerve
                                                                                3
                                                                          ARM
A. Rotator cuff
   D. Deltoid muscle
                                                      A. Axillary nerve
Q. After a road traffic accident, a 35 yr. old
   male presents in emergency with fracture at        B. Radial nerve
   the arrow marked location. He presents with
                                                      C. Ulnar nerve
   inability to extend his wrist. On examination,
   there is loss of sensation of dorsum of lateral    D. Median nerve
   aspect of hand and fingers. Which nerve will be
   injured in this case? (FMGE 2020)
                                           FOREARM
A. Anterior Compartment
                                                             Revision Capsule:
                                                                •• Cadaveric images
    Cubital Fossa:                                              •• Nerve supply of BBC:
       •• Triangular, muscular depression in front of the       •• Clinical integration with Radio & Ortho
          elbow.
    Importance of cubital fossa -                            PYQs:
    1. Measurement of Blood Pressure                         Q. A patient visited to trauma & casualty ward with
                                                                multiple fracture of shaft of humerus. He was
    2. Biceps jerk reflex                                       having the difficulty in elbow flexion & supination.
    3. Intravenous injection site                               He also complained about loss of sensation over
                                                                lateral side of forearm. Which nerve is most
                                                                probably damaged? (NEET PG 2021)
                                                                A. Musculocutaneous nerve
B. Median nerve
C. ulnar nerve
                                                                D. Radial nerve
                                                             Q After a road traffic accident, a 35 yr old male
                                                                presents in emergency with fracture at the
                                                                arrow marked location. He presents with inability
    Boundaries -                                                to extend his wrist. On examination, there is
       •• Lateral - medial border of Brachioradialis.           loss of sensation of dorsum of lateral aspect of
       •• Medial - lateral border of Pronator teres.            hand and fingers. Which nerve will be injured in
       •• Apex - meeting point of Pronator teres and            this case? (FMGE 2020)
          Brachioradialis.
       •• Base - Imaginary line joining Medial and Lateral
          epicondyle.
       •• Roof - Skin, superficial and Deep fascia.
Causes
   •• Chronic Alcoholism
   •• Connective Tissue Disorder
   •• Rheumatoid arthritis
    Palmar interossei -
      •• Unipennate - 4/3 in number → by Ulnar nerve
                                                            A. Radial nerve
      •• Function - Adduction of fingers
                                                            B. Median nerve
      •• Middle finger has no Palmar interossei
      •• Test - Card test                                   C. Ulnar nerve
                                                            D. Musculocutaneous nerve
             ARTERIES & VEINS OF UPPER LIMB
1st part -
Vertebral artery → Lateral Medullary syndrome
Internal mammary artery → use for CABG
Thyrocervical branch → Suprascapular artery,
Inferior thyroid artery & Transverse cervical artery
(Mnemonic - SIT).
2nd part -
Costocervical trunk (only one branch)
3rd part -
Dorsal scapular artery (only one branch)
2
      Anatomy
    Allen’s test
    Make a fist → pallor occur →
    compress both radial and ulnar artery →
    open the fist → Release Ulnar artery 1st →
                                                            Reverse Allen’s test
    If redness, then ulnar artery patency is present.       Instead of Ulnar artery, release Radial artery.
    (for patency of Superficial arch)                       (for patency of Deep arch)
    Important veins of Upper limb:                          4. Medial cubital vein (Antecubital vein) → Best vein
    1. Dorsal venous arch                                      for Intravenous Infusion (as Fixed and easily seen)
    3. Basilic vein
                                                                                          3
                                                         Arteries & Veins Of Upper Limb
                                                        Dermatomes of hand:-
                                                         •• Sensory branch supplying the Lateral 3 & half
                                                            of Palmar & dorsal side(known as eye of hand)
                                                            and nail beds
                                                         •• Motor branch supplies 5 muscles of hand :- all
                                                            3 thenar muscles except adductor pollicis & 1st
                                                            & 2nd lumbrical
                                                            –– Different signs of medial nerve injury:-
                                                               (CAP-BPT)
1. Median nerve :-                                             C:- Carpal tunnel syndrome
  •• Have nerve root of C5 to T1 ( C5, C6, C7 :-               A:- Ape thumb deformity
     Lateral root, C8, T1 :- medial root)
                                                               P:- Pointing index/ Oschner’s class test
  •• This nerve gives no branch in the arm
                                                               B:- Benediction hand / pope hand deformity
  •• It passes Lateral to brachial artery and at
                                                               P:- Phalen’s sign
     coracobrachialis, it crossing it & come medially
     & reach to cubital fossa                                  T:- Tinel sign
      •• Ulnar nerve getting thickened in leprosy behind         •• E:- Egawa test( positive in dorsal interossei
         medial epicondyle.                                         damage)
Focus Areas for Exams:                                 Q. Identify the nerve involved in test? (NEET PG
                                                          2021)
  •• Cadaveric images & Nerve supply of muscles
  •• Clinical tests I signs integrated with Medicine
     & Orthopaedics
Revision Capsule/PYQs:
  •• Which nerve is known as "Labourer’s nerve”:          A. Musculocutaneous nerve
                                                          D. Musculocutaneous nerve
                        NERVE OF UPPER LIMB -2
  •• It will give rise to 3 branches Above radial              –– Superficial branch:- runs towards wrist and
     groove or axilla :- (LMP)                                    makes roof of Anatomical snuff box & gives
     –– Long head of triceps                                      cutaneous branches to the lateral 2½ dorsum
                                                                  of hand except nail beds.
     –– Medial head of triceps
                                                               –– Deep branch/      PIN:- pierces supinator
     –– posterior cutaneous nerve of arm
                                                                  muscle
  •• Gives 5 branches (3 muscular) in radial groove
     (spiral groove):- (MLA)
                                                          Clinical :-
     –– Medial head of triceps
                                                            •• Crutch palsy
     –– Lateral head of triceps
                                                               –– If fracture at axilla ( loss of extension of
     –– Anconeus                                                  elbow, wrist and fingers)
A. Radial nerve
                                                          C. Median nerve
   A. Extensor pollicis brevis and abductor pollicis
                                                          D. Ulnar nerve
      longus
   D. Treatment is surgery
       Anterior Compartment of Thigh
THIGH
                                                       Femoral Triangle
                                                          •• Triangular Muscular depression below inguinal
                                                             ligament.
                                                          •• Floor (Mnemonic - APPI) - Adductor longus,
                                                             Pectineus, Psoas major tendon & Iliacus.
                                                          •• Lateral boundary - Medial border of sartorius
                                                          •• Medial boundary - Medial border of Adductor
                                                             longus
                                                       Content - (Medial to Lateral → VAN)
                                                       V - Femoral vein
                                                       A - Femoral artery
                                                       N - Femoral nerve
                                                          •• Femoral sheath - Deep fascia modification
                                                             around femoral vessels.
                                                          •• Contents : Femoral vein, artery and Lymph
Great saphenous vein - Pierces the Cribriform fascia         nodes (Not Femoral Nerve).
by making an opening called as saphenous opening and      •• Femoral canal → medial most part of Femoral
receive 3 tributaries:                                       sheath (contain Deep Inguinal Lymph node- →
1. Superficial external pudendal vein                        aka Lymph nodes of Rossenmuller and Cloquet).
                                                       SURGERY-ANAT INTEGRATION
                                                       A. Femoral Herni
                                                       1. Wider pelvis
                                                       2. Smaller vessels
                                                       Femoral hernia reduction - By Cutting of Lacunar
                                                       ligament.
4
      Anatomy
                                                          PYQs:
                                                          Q. Identify the type of muscle shown in the image
                                                             below? (NEET PG / INICET PATTERN)
                 Posterior Compartment
2
      Anatomy
ANAT-ORTHO INTEGRATION
Trendlenberg’s Sign:
Normal = During elevation of one limb → Gluteus medius, minimus & Tensor fascia
lata of opposite side contract → Pulling/Elevate the opposite side
ASIS/Pelvis → Preventing Sagging of Pelvis.
Superior Gluteal nerve injury → Sagging of Pelvis occurs
i.e. Positive Trendelenburg’s sign.
Gait is known as
In case of Unilateral palsy - Lurching gait
In case of Bilateral palsy - Duck gait or Waddling gait
   •• Gluteus maximus is supplied by:                           C. Gluteus minimus, Tensor fascia lata &
                                                                   Piriformis
   •• Gluteus medius is supplied by:
   •• Abduction Of hip is done by:                              D. All are correct
   •• 1M injection in gluteal region is given in:           Q. Which muscle is attached in this indicated part?
                                                               [NEET PG PATTERN]
   •• Identify the Piriformis & Quadratus femoris
      (NEETPG 2016)                                             A. Gluteus maximus
B. Gluteus medius
C. Gluteus minimus
                                                                –– Popliteal vein
                                                                –– Popliteal artery
                                                                –– Popliteal lymph nodes
                                                           Revision Capsule/PYQs:
                                                             •• Hamstring muscles are supplied by:
                                                             •• Action Of hamstring:
                                                             •• Weaver’s bottom is:
                                                             •• Boundaries of popliteal fossa:
    •• Boundaries of popliteal fossa:-
                                                             •• Relation of contents of popliteal fossa from
       –– Supero-lateral - biceps femoris                       superficial to deep is:
       –– Supero-medial   -   semitendinosus   &   semi
          membranes                                        PYQs:
       –– Infero-lateral - lateral head of gastrocnemius   Q. Popliteal artery ends at?
       –– Infero-medial - medial head of gastrocnemius
                                                              A. Upper border of popliteus
          ( ossification of bone here known as Fabella)
    •• Content of popliteal fossa (medial to lateral -        B. Lower border of popliteus
       Artery → vein → nerve (AVN)
                                                              C. Upper border of plantaris
       –– Tibial nerve
                                                              D. Lower border of plantaris
       –– Common peroneal nerve
         NERVES OF LOWER LIMB ANATOMY
Lumbar plexus
1. Femoral nerve
2. Obturator nerve
FOOT DROP
                                                       Revision Capsule/PYQS:
                                                         •• Sartorius is supplied by:
                                                         •• Referred pain of knee is felt at hip joint due
                                                            to:
                                                         •• Root value of sciatic nerve:
                                                         •• Root value of superior gluteal nerve:
                                                         •• Root value of inferior gluteal nerve:
               LEG COMPARTMENT
•• March Fracture:-
3. Posterior compartment:-
  •• Superficial group - have gastrocnemius, soleus
     (helping in cardiac output so it is aka Peripheral
     heart), plantaris “(GSP)”
  •• Plantaris & palmaris longus both use in tendon
     grafting operations.
A. Anterior
B. Lateral
C. Superficial posterior
D. Deep posterior
                                       Arches of foot -
                                         •• It is due to special arrangements of foot bone
                                            due to close interlocking short & small bones.
                                         •• Arches are helpful for running , walking and
                                            standing.
                                         •• Deformities of foot:
             Radiology integration :
2
      Anatomy
                                                         PYQs:
                                                         Q. Ligaments not attached to talus?
A. Talo-navicular ligament
B. Spring ligament
C. Deltoid ligament
D. Cervical ligament
A. Talo-navicular ligament?
                                                            B. Spring ligament
 •• The lisfranc ligament connects the medial
    cuneiform to the base of the 2nd metatarsal.            C. Deltoid ligament
  •• Arches of foot & foot deformities                   the base of the 2nd metatarsal? [INI-CET 2022
                                                            Pattern]
  •• Ligaments of foot
                                                         A. Chopart
                                                         B. Spring
Revision Capsule/PYQs:
                                                         C. Lisfranc
  •• Ligament below head of talus/ supporting
     head of talus:                                      D. Deltoid
  •• Mid-inguinal point where we feel the femoral     •• At lower border of Popleteus muscles:-
     artery pulses is known as the Vascular sign of      popliteal artery continue into Anterior Tibial
     narath.                                             Artery (ATA) & Posterior Tibial Artery (PTA).
  •• Hiatus Magnus:- where femoral artery converts    •• ATA ends between 2 malleoli & continues as
     into popliteal artery.                              Dorsalis Pedis Artery (DPA).
                                                      •• PTA is palpable just behind the medial malleolus.
2
    Anatomy
              •• Clinical:-
                 –– Smoking leads to atherosclerosis, gangrene,
                    thromboangiitis obliterans or buerger’s
                    disease.
                 –– Palpable arteries of LL:-
                     Femoral Artery - at head of femur
                     Popliteal Artery - lower border of Popleteus
                     ATA- between 2 malleoli
                     PTA- behind medial malleolus
                     DPA- palpable against navicular bone
    CLINICAL :                                            PYQs:
       •• Phlebotomy :- cutting the vein                  Q. A patient Who underwent Varicose veins surgical
       •• Hemochromatosis :- excessive iron                  treatment now presents with loss of sensation in
                                                             medial leg. Which Of the following is injured in
       •• Sural nerve having S1 nerve root
                                                             this patient? [NEET pattern 2021 & 2022]
       •• Medial part of leg and foot have L4 dermatome
                                                               A. Sural Nerve
       •• GSV used for bypass surgery in 40 – 50% MI
          blockage , now a days we use internal mammary        B. Saphenous Nerve
          artery (radial & ulnar vein also)
                                                               C. Obturator Nerve
D. Plantar Nerve
                                                          PYQs:
                                                          Q. Which artery is palpated here?     (June FMGE
                                                             2022 & Dec FMGE 2021)
    Revision Capsule:
    Femoral artery is palpable against:
    Popliteal artery is palpable against:
    Dorsalis pedis artery is palpable against:
    Posterior tibial artery is palpable against:          A.      post tibial artery
    Great saphenous vein is related to which nerve:
                                                          B.      Medial plantar artery
    Short saphenous vein is related to which nerve:
                                                          C.      Anterior tibial artery
5 Layers of scalp:-
1. Skin
2. Connective tissue
3. Aponeurosis
4. Loose areolar connective tissue
5. Pericranium
Clinical:-
   •• Loose areolar connective       tissue   layer   is
      Dangerous area of scalp
   •• Surgical layers of scalp
   •• Black eye
   •• Cephalhematoma
2
      Anatomy
       •• Caput succedaneum (Risk factor - vacuum                •• Grief muscle - Depressor labii inferioris
          delivery)
                                                                 •• Dimple location:- Modiolus
    Dissection of face -
    1. Skin
    2. Superficial Fascia
    3. Deep Fascia -nt but only present in buccopharyngeal
       fascia & parotido-masseteric fascia (In all other
       part of face, thorax and abdomen Deep Fascia is
       absent)
    4. Subcutaneous Muscles (in animal it is known as
       panniculus carnosus)
       •• Remnants of this panniculus carnosus are - face
          muscle, Palmaris Brevis, dartos muscle, cutis ani.
                                                                 •• Bell’s palsy - Loss of Wrinkling, Wide palpebral
                                                                    fissure, Whistling loss, loss of nasolabial fold
                                                                    and drooling of saliva.
      •• Supra trochlear vein & supraorbital vein :- both   •• Facial vein + anterior division of        Retro
         are uniting near the medial Angle of eye → make       mandibular vein = Common Facial vein
         Angular vein
      •• Angular vein continues into Facial vein            •• Posterior division of Retromandibular vein +
                                                               Posterior auricular vein = External jugular vein
      •• Superficial Temporal Vein → uniting with
         Maxillary vein = together they make                •• Sigmoid sinus continues into Internal jugular
         Retromandibular vein                                  vein
      •• Retromandibular vein divides into Anterior &       •• EJV is used for measurement of JVP (MEDICINE
         posterior division
                                                               INTEGRATION)
    Dangerous area of face :-                               •• Lower part of nose & upper lip = known as
                                                               Dangerous area of the face
                                                            •• Deep Facial vein uniting with the veins of
                                                               pterygoid plexus
                                                            •• In brain we have 1 sinus which have multiple
                                                               caves = known as Cavernous sinus
                                                            •• Emissary veins = connects extra Cranial veins &
                                                               Intracranial veins
                                                            •• Way of spreading infection of Dangerous area
                                                               :-
                                                               –– Lower part of nose / upper lip → Facial vein
                                                                  → Deep facial vein → pterygoid plexus →
                                                                                                              3
                                                                                   Vessels & Nerves Of Face
                                                      Trigeminal neuralgia :-
                                                      Type of treatment       Mode of treatment
                                                      Medical treatment       Carbamazepine
     `                         		
                                                                              Levetiracetam
Nerves of face:-
                                                                              Topiramate
  •• Motor :- 7th Cranial nerve except LPS ( by 3rd
     Cranial nerve)                                                           Phenytoin
                                                      Treatment of choice :-
                                                      Carbamazepine > valproate , Gabapentin > Surgery
  •• Ophthalmic division (V1) branches :- “(Su Su
     LIE)”
     –– Supratrochlear nerve
     –– Supraorbital nerve
     –– Lacrimal nerve
     –– Infratrochlear nerve
     –– External Nasal nerve → supplies tip of nose
  •• Maxillary division (V2) branches :- (ZIZa)
     –– Zygomatico Temporal division
     –– Infra orbital nerve
4
    Anatomy
Revision Capsule:
  •• Contents of carotid sheath:
  •• Nerve supply of trapezius:
  •• Nerve supply of digastric:
             CRANIAL CAVITY, NERVE, VESSELS
    Focus Areas for Exams:                                 Q. Which of the marked sites SARS- COVID 19
       •• Foramen & structures passing through it             spread to the brain? (INI-CET2021 pattern)
    PYQs:                                                     B. C
    Q. A patient after a road traffic accident presents       C. B
       to the emergency room with difficulty in
       Swallowing and slurred speech. Investigations          D. A
       reveal fractures in the occipitotemporal region.
       Which of the following areas should be tested in
       order to find the nerve which is involved? [INI-
       CET2021 pattern)
       A. 1
       B. 2
       C. 3
       D. 4
FOLDS OF DURA MATER & SINUSES OF BRAIN
    Cavernous sinus:-
                                                                                                             3
                                                                                       Folds Of Dura Mater
Cavernous sinus thrombosis : Ophthalmoplegia: •• Internal Jugular vein formed by:- sigmoid sinus
                                                      Revision Capsule:
                                                         •• Great cerebral vein drains into the:
                                                         •• Straight sinus is formed by:
                                                         •• Pterion is related to Which artery:
                                                         •• IJV is formed by:
                                                         •• EJV is formed by:
                                                         •• pulsatile exophthalmos is seen in:
  •• In case of increased intracranial pressure /
     head injury :- Most common CN damage is 6th
     Cranial nerve.                                   PYQs:
  •• Cavernous sinus thrombosis :- Dangerous area     Q. Which structure is related to marked point?
     of face, if Internal Carotid artery is damaged
     then the ophthalmic artery also involves which
     leads to pulsatile exophthalmos.
  •• Central part of Pterion → k/a Sylvian point →
     Cranium is very thin here (CRANIOTOMY) →
     deep to it Middle meningeal vessels lies → so
     ruptures easily → results in EDH
B. Mandibular nerve
Cricopharyngeal junction :
  •• located at level of C6
  •• it is the narrowest part of GIT                      PYQs
  •• Here the pharynx ends & esophagus starts.            Q. A patient after a road traffic accident presents
  •• Here the larynx ends & the trachea starts.              to the emergency room With difficulty in
                                                             swallowing and slurred speech. Investigations
Pharynx:-                                                    reveal fractures in the occipitotemporal region.
Upper part of Oesophagus                                     Which of the following areas should be tested in
Boundaries:-                                                 order to find the nerve which is involved? (INI-
                                                             CET 2021 pattern]
  •• Nasopharynx:- Anterior - Nasal cavity ,
     Superior - Base of skull, Posterior - C1, Inferior      A. 1
     - Oropharynx
  •• Oropharynx:- Anterior - oral cavity, Superior           B. 2
     – Nasopharynx, Posterior - C2,C3,
                                                             C. 3
     Inferior – Laryngopharynx
  •• Laryngopharynx:- Anterior - larynx, Superior            D. 4
     – Oropharynx,Posterior - C4-C6, Inferior –
     esophagus
2
    Anatomy
    Q. A 12 year old presented with fever and          Q. Which skull foramina is formed by 3 bones?
       difficulty swallowing. He had swelling in the      (INI-CET 2022 Pattern)
       marked region and was advised to undergo
       surgery. Post-surgery the gauze continued          A. Foramen lacerum
       to soak with blood. Which of the following         B. Foramen magnum
       vessels must have been injured? (INI-CET
       2021 Pattern)                                      C. Foramen rotundum
D. Foramen jugulare
C. Paratonsillar vein
       D. Retromandibular vein
                  PARASYMPATHETIC GANGLION
                                                          1. Ciliary ganglion:-
                                                            •• It is a parasympathetic Ganglion which is
                                                               related to 3rd CN
  •• Collection of many cell bodies within the CNS          •• Size - pin head size
     is known as nucleus & outside the CNS is known
     as ganglion.
  •• Fibers before the ganglion are known as
     preganglionic fibers & after it are known as
     post ganglion fibers.
  •• Pseudoganglion is a collection of fat & connective
     tissue, no nerve elements are present but it
     appears like ganglion. It is present in the nerve
     to teres minor which is a branch of axillary
     nerve & in the radial nerve too.
      •• Parasympathetic action of ciliary ganglion:-            Superior rectus muscle & Levator palpebrae
                                                                 superioris.
         –– 3rd CN is running to the Lateral wall of
            Cavernous sinus & in its apex, it is divided      –– Inferior division supplies Medial rectus,
            into superior & inferior division .                  Inferior rectus & Inferior oblique muscle
                                                                 and ends into ciliary ganglion.
         –– It passes through superior orbital fissure,
            here superior division gives branches to          –– from ciliary ganglion Short ciliary nerves
                                                                 arise, which supply to constrictor pupillae.
•• Inferior salivatory nuclei will give impulses to      goes to the otic ganglion → mpulse continues
   9th Cranial nerve → which gives its branch to         into the Auriculotemporal nerve → which gives
   the tympanic cavity, known as Jacobson’s nerve.       parasympathetic supply to parotid gland →
                                                         which leads to salivary secretion.
•• Tympanic branch of the 9th Cranial nerve forms
   the tympanic plexus inside middle ear → and        •• Frey’s syndrome (or Auriculotemporal nerve/
   continues as Lesser petrosal nerve.                   ATN syndrome):- It is due to abrrent connection
                                                         of ATN to Great auricular nerve fibres / fibres
•• The Lesser petrosal nerve → comes out of the
                                                         supplying to sweat gland over parotid region.
   cranial cavity from the foramen ovale → and
4
     Anatomy
3. Submandibular ganglion:-
Revision Capsule:
Q. Which cranial nerves are parasympathetic:
    Related cranial nerves with:
A. Ciliary ganglion:
B. Otic ganglion:
C. Sphenopalatine ganglion:
    D. Submandibular ganglion:
                                       SPINAL CORD
    ANAT-PEDS-ANESTHESIA
    INTEGRATION
    Lumbar puncture → done from Lumbar Cistern at
    L3-L4 junction (Best).
    Structures pierced during L.P. :
    Mnemonic :
    3 S ILE DAS
       •• Skin
       •• Superficial fascia
       •• Supraspinous ligament
       •• Interspinous ligament
                                                         Transverse section of spinal cord:
       •• Ligamentum flavum
                                                           •• Area around central canal – Nissl’s granules →
                                                                                                            3
                                                                                              Spinal Cord
S - Substantia Gelatinosa nucleus [in Lamina 2] • Anterior spinothalamic tract - Crude touch
    ANAT-MEDICINE INTEGRATION
    1st sensation to be lost in senile age - Vibration &   DORSAL AND SPINOTHALAMIC
    Sensation(Pallanesthesia)
                                                           TRACTS:
    Stereognosis loss → Astereognosis
                                                                                                                 5
                                                                                                   Spinal Cord
DESCENDING TRACTS:
Pyramidal tract                                         Focus Areas for Exams:
                                                          •• Spinal cord     section,   tracts   &     related
  •• 80% decussate at Medulla oblongata, called the
                                                             syndromes
     Lateral Corticospinal tract.
                                                          •• Spinal nerves
  •• 20% - Don't cross and pass anteriorly, called
     the Anterior Corticospinal tract.                    •• Spinal cord ending & Lumbar puncture
A. Ligamentum flavum
B. Arachnoid mater
C. Pia mater
D. Dura mater
Brain stem is divided into 3 parts :                   •• At Medulla , 9th, 10th, 11th and 12th Cranial
                                                          nerve attached → so Medullary paralysis =
1. Medulla
                                                          Bulbar paralysis = IX , X, XI, XII paralysis
2. Pons
                                                       •• At pontomedullary junction - 6th , 7th, 8th
3. Midbrain                                               cranial nerve .
                                                       •• 7th cranial nerve has 2 divisions:
                                                          a. Medial division : motor
                                                          b. Sensory division : lateral
                                                       •• Sensory division of 7th CN is known as the
                                                          nerve of Wrisberg or Nervous intermedius.
                                                       •• 8th cranial nerve also has 2 divisions:
                                                          a.   Cochlear division
                                                          b.   Vestibular division
                                                       •• At the ventral surface of Pons, 5th cranial
                                                          nerve present & it is divided into 3 divisions (V1,
                                                          V2, V3),
                                                       •• V CN ganglion is covered with a fold of dura
                                                          mater known as meckle’s cave.
                                                       •• Above Pons there is crus cerebri → medial to
                                                          it, 3rd cranial nerve attached and 4th cranial
                                                          nerve attached posteriorly.
                                                       •• 1st & 2nd CN are attached on the inferior
                                                          surface of the frontal lobe.
                                                     Clinical Integration :
                                                     Clinical Integration :
                                                       •• In Middle medullary syndrome / Dejerine
                                                          syndrome – midline part of medulla is damaged
                                                          → hence 12th CN damage à ipsilateral tongue
  •• Medulla is a truncated bulb-like structure.          deviation is seen.
     (Medulla = Bulb)                                  •• In Lateral    medullary   syndrome/ PICA
  •• Hence medullary    paralysis   means   Bulbar        syndrome / Wallenberg syndrome / Vertebral
     paralysis .                                          artery syndrome → Lateral part of medulla
                                                          is damagedà laterally 10th nerve is located
2
    Anatomy
    •• 4 important facts about 4th cranial nerve:              •• Melatonin     responsible   for   biological   clock
       “DDLT” (Dilwale Dulhania Le Thahrenge)                     activity.
    Revision capsule:
    Cranial nerve Nuclei           Attachment         Foramen             Function & clinical
    I
    II
    III
    IV
    V
    VI
    VII
    VIII
    IX
    X
    XI
    XII
                                                                A. Lateral rectus
                                                                B. Superior oblique
                                                                C. Risorius
          A. Olive
                                                                D. Levator palpebrae superioris
          B. Pyramid
                                                            Q. At which level does the nerve supply for the
          C. Accurate nude us                                  marked structure arise? (INI-CET 2021
                                                               Pattern)
          D. Hypoglossal nucleus
A. Facial colliculus
B. Superior colliculus
C. Inferior colliculus
D. Inferior olivary
B. Weber syndrome
   D. None
                                      CEREBELLUM
•• 3 phylogenetic lobes -
                                            ●
2
    Anatomy
    •• 3 histological layers - Little brain “MPG”         •• 4 Nuclei (DEGF - in large to small & Lateral to
                                                             medial sequence)
       M - Molecular layer
                                                             –– D:- Dentate nuclei
       P - Purkinje layer                                    –– E:- Embolism nuclei
    •• 5 neurons of cerebellum:- (BSP GoGa)               •• Basket cells & Stellate cells located in the
                                                             molecular layer.
       –– B - Basket cells
                                                          •• Purkinje cells in the purkinje layer.
       –– S - Stellate cells
                                                          •• Golgi & Granular cells – located in the granular
       –– P - Purkinje cells :- largest, only efferent       layer.
          fibers present, inhibitory to deep cerebellar   •• Blood supply -
          nuclei.
                                                             a. PICA: Posterior Inferior Cerebellar Artery
       –– Go - Golgi cells                                   b. AICA: Anterior Inferior Cerebellar Artery
       –– Ga (sir):- Granular cells                          c. SCA: Superior Cerebellar Artery
                                                                                                              3
                                                                                                 Cerebellum
                                                       •• Functions of cerebellum -
                                                          –– Having proper 3 dimensional balance.
                                                          –– Maintain rate and range of direction.
                                                          –– Holding things by proper force.
                                                       •• Defect lead to - “NIDRA”
                                                          –– Loss of tone, posture and equilibrium.
                                                          –– Ataxia
                                                          –– N - Nystagmus
                                                          –– I -Intentional tremor
 •• Wallenberg syndrome / Lateral medullary               –– D - Dysdiadochokinesia
    syndrome:- loss of pain & temperature of 1 side
                                                          –– R - Rhomberg sign
    of face and opposite side of body along with
    vagus nerve damage.                                   –– A - Ataxia, Asynergia
    PYQs:
    Q. In given MRI image identify the structure?
       (NEET 2019 PATTERN)
A. Hypothalamus
B. Thalamus
C. Cerebellum
D. Pituitary
A. Dentate
B. Emboliform
C. Globose
       D. Fastigial
                BLOOD SUPPLY OF BRAIN
                                     5 components of circle of
                                     willis(COW):-
                                     1. Anterior cerebral artery
                                     2. Anterior communicating artery
                                     3. Internal Carotid artery
                                     4. Posterior communicating artery
                                     5. Posterior cerebral artery
                                     Clinical :
                                       •• Aneurysm of COW is known as Berry aneurysm.
                                       •• Berry aneurysm rupture lead to subarachnoid
                                          hemorrhage → Blood in CSF (complain of patient
2
     Anatomy
PYQs:
Q. Blood supply of medial surface of brain is? (NEET
    16 SESSION 10)
   A. Anterior cerebral artery
   B. Basilar artery
   C. Middle cerebral artery                              A. Anterior cerebral artery and            middle
                                                             cerebral artery
   D. posterior cerebral artery
Q. Which artery supplies the paracentral lobule?          B. Anterior cerebral artery and posterior
   (NEET 16 SESSION2)                                        cerebral artery
   A. Medial striate artery
                                                          C. Anterior cerebral artery       and     anterior
   B. Calloso-pericallosal artery                            communicating artery
   C. Frontopolar artery                                  D. Middle cerebral artery and           posterior
   D. marginal artery                                        cerebral artery
Cerebral hemisphere:-
    2. Temporal lobe -
      •• Superior Temporal gyrus have area 41, 42 -
         are 1° auditory / Auditory Sensory area.
         –– Area 22 - 2° auditory or auditory psychic
            area and due to its damage, a person will be
            able to hear but not able to analyze what it
            means (auditory agnosia).
         –– Posterior part of Area 22 known as
            Wernicke's area or Sensory speech area
            and its damage leads to sensory aphasia.
         –– Medial part of this lobe is known as Area 28
                                                                  –– Have visual-striated areas or lines of Genneri.
            (olfactory area).
C. Angular gyrus
                                                        Projection fibers :-
                                                        Include all tracts
                                                        Ascending:-
                                                          •• LSTT (Lateral Spino-thalamic Tract)
                                                          •• FG (Fasciculus Gracilis)
2
      Anatomy
–– C : Claustrum
                                                  Revision Capsule:
                                                    •• Corpus callosum is which type of white matter:
                                                    •• Fornix is Which type Of White matter:
                                                    •• Lateral spinothalamic tract is which type of
                                                       white matter:
                                                    •• Lesion to subthalamic nucleus of Luys results
                                                       in:
                                                    •• Lesion to substantia nigra results in:
                                                    •• Lesion to cerebellum results in:
                                                  PYQs:
                                                  Q. A Patient presents with Ballistic involuntary
                                                     movements. Which Of the following is
                                                     Responsible? (NEET PG 2022)
A. Caudate Nucleus
B. Thalamus
C. Substantia N
    Q. Fibres of the given structure originate from?    Q. Which fibre is marked by the arrow in the image
       (INI-CET 2022 pattern)                              given below? (NEET PG 2019)
A. Amygdala
       B. Mammillary body
                                                           A. Short association
       C. Caudate nucleus
                                                           B. Long association
       D. Hippocampus
                                                           C. Projection
    Q. A Woman With right -Sided loss of sensations
       of both the upper and lower limb complains          D. Commissural
       of shooting pain from her fingers to the right
       shoulder and a burning sensation when touching
       cold water. Motor functions are normal. Which
       of the following is likely to be involved?
A. A
B. B
C. C
       D. D
                                 CRANIAL NERVES
    Revision Capsule:
      •• Optic chiasma damage results in:
      •• Cranial nerves supplying EOMs:
      •• Right side deviation of tongue is due to:
      •• Nerve supply of tonsil is:
      •• Tensor palatine is supplied by:
      •• Stylopharyngeus is supplied by:
      •• Cricothyroid is supplied by:
      •• Palatoglossus is supplied by:
THORACIC WALL & INTERCOSTAL SPACE
( VIT – CD)
Intercostal veins:-
4
     Anatomy
    Exam:
       •• Intercostal muscles, nerves, arteries & veins
       •• "VAX” relation in intercostal space
       •• Thoracocentesis
    Revision: In costal relation of vessels are: VAN
    (Vein, Artery, Nerve)
    VAN Relation is not present in which Intercostal
    space: 1st
    Best artery CABG: left Mammary artery mammary
    artery divides in which Intercostal space;
    6th Intercostal space Left superior intercostal vein
    drains into; Left Brachiocephalic vein
    PYQs:
    Q. Inferior thyroid artery supply which of the
       following structures? (INI-CET 2021 Pattern)
1. Thyroid
2. Parathyroid
3. Esophagus
4. Thymus
A. 1, 2, 3, and 4
B. 1, 2, and 3 only
C. 1 and 2 only
D. 1, 2 and 4 only
C. Azygous Vein
       D. Brachiocephalic vein
                                    PLEURA & LUNG
                                                           •• Left lung :-
                                                              –– Upper lobe :-has  Apical, Anterior, Posterior,
                                                                 Superior & Inferior lingual
                                                              –– Lower lobe :- has Apical Basal, Anterior Basal,
                                                                 Lateral Basal, Posterior Basal, Medial basal
                                                                 (+/-)
PYQs:
Q. Arrange lung hilar structures from anterior to
   posterior? (INI-CET 2022 Pattern)
1. Primary bronchus
2. Pulmonary vein
3. Bronchial artery
4. Pulmonary artery
A. 1,2,3,4
B. 2,3,4,1
C. 3,4,1,2
D. 4,3,2,1
C. Trachealis
   D. Hyoid Bone
   MEDIASTINUM, PERICARDIUM & SINUSES
Clinical integration:
  •• Esophagus & trachea is having common
     communication = known as Tracheo-esophageal
     fistula.
  •• Which Leads to aspiration pneumonia
2
     Anatomy
    Pericardial sinuses
    1. Transverse sinus
      •• anterior boundary : formed by Ascending aorta
         & pulmonary trunk
      •• clinical : it is used to ligate ascending aorta &
         pulmonary trunk
    2. Oblique sinus
      •• Anterior Boundary formed by left Atria → have
         openings of 4 pulmonary veins
      •• clinical : This sinus indirectly maintain the
         cardiac output
                                                       3
                  Mediastinum, Pericardium & Sinuses
Revision Capsule:
  •• Sterna' angle is located at which vertebral
     level:
  •• Important content of middle mediastinum:
  •• Important content of posterior mediastinum:
  •• Important content of superior mediastinum:
          HEART & CORONARY CIRCULATION
  •• Heart is conical muscular hollow viscera which is   Right Atria: Internal Features
     responsible for pumping the blood.
                                                           •• Rough part
  •• it is located in the middle mediastinum within           –– Crista terminalis
     the pericardium.
                                                              –– Musculi pectinati
EXTERNAL FEATURES OF HEART :                               •• Smooth part
                                                              –– All venous openings are present here
                                                           •• Inter Atrial Septum
                                                              –– Fossa Ovalis
                                                              –– Annulus fossa ovalis
                                                         AV Node: Located within Triangle of KOCH
RADIOLOGY-ANATOMY INTEGRATION
Right heart border – RA + SVC + IVC
                                                         Arterial Supply of the Heart
                                                           •• The root of the ascending aorta has semilunar
                                                              valve which is having 3 leaflets
                                                              –– Anterior leaflet
                                                              –– Left Posterior leaflet
                                                              –– Right posterior leaflet
                                                           •• Cavity b/w the aortic wall and leaflet margins is
                                                              the Aortic Sinus
                                                              –– Anterior Aortic Sinus – gives rise to Right
                                                                 Coronary Artery → Rt. Conus artery
                                                              –– Left posterior aortic sinus – gives rise to
                                                                 Left Coronary Artery
                                                              –– Right posterior aortic sinus
2
     Anatomy
                                                     RISK FACTORS
                                                       •• Non – modifiable
                                                          –– Age
    LCA: Course & Branches
                                                          –– Sex
                                                          –– Genetic factor
                                                          –– Familial factor
                                                       •• Modifiable
                                                          –– Major RF –
                                                              Hypertension
                                                              Hyperlipidemia
                                                              Hyperglycemia
                                                              Smoking
                                                          –– Minor RF –
    Main Branches “DAL”                                       Alcohol
      •• Diagonal artery
                                                              Estrogen – preventive
      •• Anterior Interventricular artery (AIVA) –
                                                              Homocysteine
         supplies the Apex
      •• Left Circumflex artery                      Widow’s artery/ Widow maker artery – LADA
                                                                                                              3
                                                                               Heart & Coronary Circulation
3. ECG
4. ANGIOGRAPHY
5. ANGIOPLASTY
6. CABG
                                                      ANGIOPLASTY
  •• Largest vein – Coronary sinus (situated in the
     left posterior Interventricular sulcus)
  •• All the cardiac veins drain into the coronary
     sinus except 2 –
     –– Anterior cardiac veins & Venae Cordis
        minimae – drain into Rt. Atria
  •• Great cardiac vein runs with the AIVA & Lt.
     CXA
  •• Middle cardiac vein running with the PIVA
  •• Right Marginal vein making the small cardiac
     vein which is draining into the Coronary sinus
4
     Anatomy
ANTI-ANGINAL DRUGS
                                                         PYQs
                                                         Q. Base of the heart is formed by: (NEETP 16
                                                            SESSION 2)
A. Right atria
B. Left atria
C. Right ventricle
                                                            D. Left ventricle
                                                                                   5
                                                    Heart & Coronary Circulation
   D. Coronary sinus
                ANTERIOR ABDOMINAL WALL
•• Thoracoabdominal diaphragm divides the trunk        –– Umbilicus is situated at L3,L4 ( it’s a site for
   into thorax and abdomen.                               Iliac crest & Lumbar puncture).
                                                       1. Skin
  –– AAW is divided into 9 quadrants by 2 vertical     2. Superficial fascia
     lines & 2 horizontal lines.
                                                       3. External oblique
  –– Transpyloric plane passing through the lower
                                                       4. Internal oblique
     border of L1.
                                                       5. Transverse abdominis
  –– Subcostal plane passing through upper border
     of L3 level.                                      6. Transversalis Fascia
                                                       7. Extra peritoneal fat
  –– Transtubercular plane passing through upper
     border of L5.                                     8. Peritoneum
2
    Anatomy
                                                                                                                  3
                                                                                                   Introduction
  •• Boundaries of Inguinal canal :-
                                                             PYQs:
                                                             Q. What is the level of the indicated plane in the
                                                                abdomen? (June FMGE 2022)
A. T12
B. L1
C. L2
D. L3
B. pectineal ligament
C. Lacunar ligament
D. Arcuate ligament
B. B
C. C
    D. D
   PERITONEUM & ABDOMINAL LIGAMENTS
–– Foramen of Winslow:- It is communication between greater & lesser sac aka epiploic foramen.
•• Pringle’s maneuver:-
4
     Anatomy
•• Clinical Integration.
                                                        Exams:-
                                                           •• Superior Boundary of Foramen of Winslow:
                                                              Liver
                                                           •• Contents of free margin of lesser omentum:
                                                              VAD (Vein, Artery. Duct)
                                                           •• Artery    within   gastrosplenic     ligament:
                                                              Gastrosplenic & Short Gastric
     Epiploic Foramen (Boundaries) -
                                                           •• Artery within lienorenal ligament :splenic
     Anterior - Right free margin of lesser omentum           artery
     Posterior-
     IVC
     Right Suprarenal
     T 12
     Superior-Caudate process of liver
                                                        Pyqs:-
                                                        Q A 30 yr old male presented in the clinic with
                                                           pain in left hypochondrium. On examination,
                                                           the spleen was measured 18 cm & extending
                                                           to the umbilical region. This extension of the
                                                           spleen is prevented by? (NEETPG 2021)
  •• It is a muscular tube which joins the pharynx to     4 constrictions of the Esophagus – measured from the
     the stomach.                                         upper incisors
•• D – Duodenum •• S – Stomach
•• U – Ureter
    SURGERY-ANATOMY INTEGRATION
    Parts of Esophagus           Artery               Vein                         Lymph node
    Upper 1/3rd part             Inferior     thyroid Inferior thyroid vein – Deep cervical LN
                                 artery               Brachiocephalic vein (BCV)
    Middle 1/3rd part            Esophageal br. from Azygous vein                  Mediastinal LN
                                 Descending thoracic
                                 aorta
    Lower 1/3rd part             Left gastric artery Left gastric vein             Left gastric LN
                                 (esophageal branches)
                                                       “BAL” – mnemonic
                                 “OIL” – mnemonic
    STOMACH
    Parts of Stomach
      1. Cardiac part
         a. Fundus
         b. Body
      2. Pyloric part
         a. Pyloric Antrum
         b. Pyloric Canal
    ANAT-PATHO-MEDICINE-SURGERY
    INTEGRATION
    Pyloric antrum is the 2nd most common site for the
    Duodenal Ulcer Disease (DUD)
    Incisura Angularis is most common site for Gastric
    ulcer Disease (GUD)
                                                                                                         3
                                                                                   Esophagus & Stomach
GUD CLASSIFICATION
                                                           ANAT-SURGERY INTEGRATION
                                                           ESOPHAGEAL REPLACEMENT SURGERY
                                                              •• In case of esophageal replacement surgery,
                                                                 the best site for the graft is the part
                                                                 of the stomach where the left and right
                                                                 gastroepiploic artery anastomosis or also the
                                                                 lesser curvature part where the right and
                                                                 left gastric arteries are anastomosing
                                                              •• To prevent the bleeding from the Duodenal
                                                                 ulcer, the artery ligated will be Gastroduodenal
                                                                 artery
                                                           LYMPHATIC DRAINAGE OF
    •• Give 3 main branches
                                                           STOMACH
       –– Left gastric artery – supply lower end of the
          esophagus
       –– Splenic artery –
           Arteria pancreatica magna – supply body of
              pancreas
           Short gastric vessels
           Left gastroepiploic artery
       –– Common hepatic artery
          Proper hepatic artery
              ○○ Left hepatic branch
              ○○ Right hepatic branch
          		     Cystic artery (to gallbladder)
              ○○ Right gastric artery (anastomose with
                                                             •• ● All the LNs drain into the Celiac nodes
                 the left)
           Right gastroduodenal artery                   ANAT-PATHO INTEGRATION
              ○○ Right     gastroepiploic         artery   In case of Stomach Ca – enlargement of left
                 (anastomose with the left)                supraclavicular LN =
              ○○ 		Superior pancreaticoduodenal artery
                                                              •• Virchow’s LN
                 Anastomose    with    the   inferior
                 pancreaticoduodenal artery – br. of          •• Troisier’s sign
                 the IMA                                   In case of Stomach Ca – enlargement of left
    •• Anastomosis between superior and inferior           axillary LN = Irish LN
       pancreaticoduodenal artery                          In case of Stomach Ca – enlargement of periumbilical
       –– Junction between foregut and midgut              LN = Sister Mery Joseph Nodules
       –– Opening of CBD                                   In case of Stomach Ca – there is trans celomic
                                                           spread – Ovarian Ca = Krukenberg’s tumor
                                                                                                           5
                                                                                    Esophagus & Stomach
                                                        D. Left bronchus
Revision Capsule:
  •• Constrictions of oesophagus                     Q. Left atrium is present at which level? (FMGE Jan
                                                         2023)
  •• Vascular supply of oesophagus & stomach
  •• Vagotomy operation
  •• Virchow's lymph node
PYQs
Q. In case of duodenal ulcer bleeding which artery
   is ligated to check it ?
   A. Right gastroepiploic artery
C. Gastroduodenal artery
A. A
B. B
C. C
                                                        D. D
                 SMALL & LARGE INTESTINES
Duodenum: –– D4 → 1 inch
 •• Shorterst , widest & most fixed part of small     –– Total 10 inches × 2.5 = 25 cm
    intestine                                       •• IMPORTANT Relations
 •• 4 parts : D1, D2, D3, D3                          –– 1st part of Duodenum: anterior to head of
                                                         pancreas
 •• Extension : between L1 to L3 Vertebra, above
    umbilicus                                         –– 2nd part of Duodenum: anteriorly related to
                                                         Rt. Kidney
 •• Total length : 25 cm
                                                      –– Gallbladder fundus is in front of 2nd part of
   –– D1 → 2 inches → located at L1                      duodenum
   –– D2 → 3 inches → L2                              –– SMA & vein passing anterior to 3rd part of
   –– D3 → 4 inches → L3                                 Duodenum
2
     Anatomy
    Large Intestine
      •• 8 parts of large intestine
         –– Ascending colon
         –– Transverse colon
         –– Descending colon
         –– Sigmoid colon
         –– Caecum
                                                           Caecum
                                                            •• Junction between small & large intestine
         –– Appendix                                           represented by Ileo-caecal junction (ICJ)
         –– Rectum                                          •• ICJ is opening into caecum
         –– Anal canal                                      •• ICJ It is the most common site for:
      •• Main 3 Features of Large Intestine                   –– Abdominal TB
         1. H :- Haustra / Saccule                            –– Intussusception
         2. A :- Appendices epiploicae = small pouch of       –– Crohn’s  Disease      (Inflammatory   Bowel
            fat                                                  Disease)
Clinical :
  •• Inflammation of Caecum → Typhlitis → 2 types
     : acute & chronic
Appendix
  •• Worm like structure which is vestigial now.
  •• length : 2 to 20 cm.
  •• lumen 1 mm. (narrower than CPJ)
                                                      •• Appendicular artery = Example of end artery ,
  •• fold of mucosa present in between appendix          Most commonly involve in Appendicitis
     & caecum known as valve of Geralach. It is a     •• The accessory appendicular artery, also known
     pseudo valve.                                       as the artery of Seshachalam, is a branch of
                                                         the posterior cecal artery. It arises from the
  •• most common site of pain due to appendicitis –
                                                         ileocolic artery, and runs in the mesoappendix.
     McBurney's point → junction at medial 2/3rd
                                                      •• Positions of appendix :
4
    Anatomy
    Revision capsule: -
      •• Length Of Duodenum: 25 cm
      •• Length of Rectum: 12 cm
                                                          A. A
      •• Length of Anal Canal: 3.8 cm > 4 cm
                                                          B. B
      •• Characteristic Features of Large Intestine:
         HAT/SAT                                          C. C
      •• No. of Houston's Valve Present in Rectum: 3      D. D
                 ARTERIES & VEINS OF GIT
•• Abdominal Aorta pierces the diaphragm and   •• At the lower border of L4 or L4-L5 junction, it
   runs in downward direction.                    is bifurcating into common iliac arteries
2
     Anatomy
                                                            SURGERY-RADIO-ANATOMY
                                                            INTEGRATION
                                                               •• When the lower pole of the kidney gets fused
                                                                  – Horseshoe Kidney. So, when this fused
                                                                  kidney is ascending upwards at that time this
                                                                  IMA will arrest it.
    SMA – arise at the level of L1
                                                               •• Radiology – horseShoe kidney is seen at the
    6 branches of SMA :                                           L3-L4 vertebrae
      •• Inferior pancreatico duodenal artery – to
         duodenum and pancreas                              VENOUS DRAINAGE OF THE
      •• Jejunal branches                                   ABDOMEN
      •• Ileal branches                                       •• Portal vein = Splenic vein + SMV
MICRO-PARASITO/SURGERY/MEDICINE-
ANATOMY INTEGRATION
Entamoeba     histolytica   infection      and    also
Hepatocellular cancer case:
  •• Chronic Alcohol – Cirrhosis/ Liver failure                  Around the umbilicus via the paraumbilical
                                                                    veins – appears as Caput Medusae
     –– There is fibrosis of the liver, so the blood is
        not drained through the liver which causes               At the lower part of the rectum-anal canal,
        ↑ blood within the portal vein and results in               there is abnormal dilatation and rupture
        Portal HTN.                                                 of the blood vessels causing Melena. This
                                                                    can lead to Hemorrhoids.
     –– Blood accumulating is spleen – Splenomegaly
                                                                 Abnormal dilatation and rupture of vessels
     –– Blood accumulating in the SMV & IMV – Ascites
                                                                    at the lower end of the esophagus
     –– When the blood is not passing through the                   resulting in the esophageal varices which
        portal vein, then there are certain sites                   causes bleeding
        where there is a meeting of the portal vein
        with the vena cava vein. This is known as
        Porto-Caval shunt.
4
    Anatomy
    SPLEEN
      •• Located in the left hypochondrium region.
      •• Costal Surface → 9th, 10th (45°) and 11th ribs.
      •• Visceral surface → Gastric, Colic, Renal and
         Pancreas impressions.
LIVER
•• Weight: 1.5 kg
         –– 1” 3” 5” : Dimensions                              •• 5 surfaces:
         –– 7 : ounce is weight
                                                                 –– Superior
         –– 9, 10, 11 : Ribs are costal relations.
                                                                 –– Right
      •• Axis along 10th rib
      •• Two surfaces                                            –– Inferior
         : Diaphragmatic ( outer ) ( Rib & intercostal 9,        –– Anterior
         10, 11 )
                                                                 –– Posterior
         : Visceral (inner)
         Visceral surface → gastric, colic, renal, pancreas    •• 5 ligaments:
                                                               •• Porta hepatis: 5 cm
                                                                                                      3
                                                                           Abdominal Viscera Organs
–– Bile duct
–– Hepatic plexus
–– For stomach
–– For Gallbladder
  –– For duodenum
  –– For right kidney
  –– For Hepatic flexor
•• Clinical correlation:
                                                Gallbladder:
                                                  •• 3 Parts: Fundus, body, neck
  ––Hepatitis: Acute & chronic
  ––Tumor: Benign (Hepatic adenocarci-
    noma) & Malignant (Hepatocellular
    cancer)
  ––Hepatectomy (right & left lobectomy)
  ––Jaundice (pre-hepatic, intra hepatic,
    post hepatic)                                 •• Hartman’s pouch is present at the neck →
                                                     common site for stone
  ––Hyperbilirubinemia:        Conjugated   &     •• Cystic duct presents a spiral valve of Heister
    Unconjugated                                     (false valve).
    KIDNEY                                                    rib & vessel on left side along with the above
                                                              mentioned structures)
                                                           •• 2 Ligaments: Medial arcuate ligament and
                                                              Lateral arcuate ligament.
                                                           •• 3 nerves: subcostal Nerve (T12), Iliohypogastric
                                                              Nerve, ilioinguinal Nerve.
                                                           •• 4 muscles: diaphragm, psoas major, quadratus
                                                              lumborum, transverse abdominis.
                                                           •• 5 Structures impression on right kidney
                                                              (Anterior surface) → right Suprarenal gland,
                                                              colon, intestinal loop, liver, 2nd part of
                                                              duodenum.
      •• Kidney is the main excretory organ in humans.     •• 6 structures impressions on left kidney
                                                              (Anterior surface) → left Suprarenal gland,
      •• it has 2 poles , 2 borders & 2 surfaces
                                                              colon, intestinal loop, stomach, spleen, pancreas.
      •• Structure at renal hilum: Anterior to posterior
                                                           •• Clinical correlation of kidney:
         - VAU (Vein, Artery, Ureter)
                                                              –– Glomerulonephritis
                                                                  Acute → Post-infectious
                                                                     glomerulonephritis, Minimal change
                                                                     disease, Membranoproliferative
                                                                     glomerulonephritis, Focal segmental
                                                                     glomerulosclerosis.
                                                                  Chronic
                                                              –– Tumor → Wilms tumor
Revision Capsule:
   •• In Acute Pancreatitis       Which   Arterial       A. Calot's triangle
      Aneurysm Is Common:
                                                         B. Hepatobiliary triangle
   •• Which Vessel Is Compressed in Case of Cancer
      of Uncinated process of pancreas:                  C. Hessalbach's triangle
   •• Portal Vein is Formed At:                          D. Gastrinoma triangle
   •• Which Muscle is Not Related to Posterior
      Surface of Ureter:
PYQs:
Q. Cholecystocaval line is in between?
Perineum
  •• Perineum is the area between two thighs
                                               Boundaries of perineum:
                                                 •• Anterior- Pubic symphysis
Anat-OBG Integration:
                                                             Clinical Significance:
                                                             Pudendal nerve supplies the penis and gives a branch
                                                             to the scrotum as posterior scrotal nerve therefore,
                                                             for any hydrocele surgery pudendal nerve is to be
                                                             blocked.
                                                                                                        3
                                                                        Perineum and Pelvic Viscera-1
                                                 Urethra:
Extra Edge:
                                                 Parts of Urethra:
    –– Fascia of denonvilliers' fascia- behind
       urinary bladder                             •• Prostatic urethra (Horseshoe shaped)
•• Bulbar urethra
                                                   •• Penile urethra
4
      Anatomy
–– Posterior
–– median
–– right lateral
–– left lateral
      •• Right and left ureters – posterolateral side         •• Ejaculatory duct opens in Prostatic urethra
                                                                 (Semilunar/Horse-shoe shaped → due to
      •• Inferiorly- Urethral opening
                                                                 pressure by median lobe)
      •• Anteriorly- Median umbilical ligament
                                                              •• Opening of prostatic utricle (remnant of
                                                                 Paramesonephric duct) → in Prostatic urethra
     1. Benign tumor - BPH (Benign prostatic                      –– Along with 5-alpha reductase inhibitors –
        Hyperplasia) → Compression symptoms as                       Finasteride
        it occurs in Periurethral zone - Urinary            •• If Medical management fails - Surgery (TURP)
        hesitancy, Urgency and increased Frequency.
It is divided into Two Common Iliac artery, which      –– Superior Rectal artery - from Inferior
further divided into two -                                Mesenteric artery ranch
      1. External iliac artery                         –– Middle Rectal artery - from Internal Iliac
      2.		Internal iliac artery                           artery
→ Anterior division - supply Pelvic viscera            –– Inferior Rectal artery - from Internal
                                                          Pudendal artery
   •• Blood supply of Urinary Bladder - Superior &
      Inferior vesical artery
                                                             3. Columnar Epithelium -
                                                               •• Nucleus is Perpendicular to the basement
                                                                  membrane .
                                                               •• Height of the cell is more.
                                                               •• Function : Synthesis and Storage function
    2. Cuboidal epithelium -
      •• Nucleus is rounded .
      •• All dimensions of cells are equal hence cube like
         appearance.
      •• Function : Synthesis and secretion
                                                             Clinical integration :
                                                               •• Immotile      Cilia    Syndrome/Kartagener
                                                                  Syndrome - because of absence of Cilia/
                                                                  Dysfunctional cilia → repeated Infections →
                                                                  repeated inflammation → Dilatation/ Ectasia
                                                                  of bronchus occurs → aka Bronchiectasis.
                                                                                                             3
                                                                                                Epithelium
Umbrella cells:
  •• Thick glycoprotein layer present → Prevent
     absorption.
  •• May appear Binucleate.                               A. Apocrine gland
  •• Internalisation of cell membrane present.
                                                          B. Merocrine gland
  •• Present in Urinary system distal to the
     Collecting duct like Bladder, Urethra (Except        C. Holocrine gland
     Membranous part & tip of urethra) etc.
                                                          D. Endocrine gland
GLANDS:
                                                       Q. Transitional epithelium is seen in?
3 types on the basis of Mode of Secretions
                                                          A. PCT
   A. Holocrine glands - Entire glands are ruptured
      and secretion released. E.g. Sebaceous Glands.      B. Loop of Henle
      Block of duct → Acne occurs.
                                                          C. Renal pelvis
   B. Apocrine glands - Only the apical portion of
      the gland is ruptured and secretions released       D. Terminal part of urethra
      in the surroundings or duct. E.g. Modified
      Sweat gland → Pheromones secreting glands
      (present in Axilla, Perineum) Breast.
   •• Identify (Chondrocytes) - contain Chondroitin         Group of cells with blue stained nucleus and
      Sulphate → Attract basic stain → Blue stain.            clear Lacuna.
E - Epiglottis                                        C - Cuneiform
2
        Anatomy
I - Intervertebral Disc
    B. BONE                                               ANAT-PATHO-MEDICINE-PEDIA
        •• No stain needed                                INTEGRATION:
        •• At centre - Haversian Canal                    Good Pasture Syndrome
        •• Volkman’s canal - joins 2 haversian canals        •• Mutation/Abnormality in Collagen type IV
        •• Osteocytes are seen.                              •• Defect in Basement membrane of Kidney :
                                                                lead to Hematuria
    Collagen
                                                             •• Defect in Basement membrane of Lungs : lead
        •• Most common protein in body                          to Hemoptysis
        •• Types = 28
                                                          Focus Areas for Exams:
    Important Types          Locations
    of collagen                                              •• Types Of cartilage with examples
Revision Capsule/PYQs:
   •• Types Of cartilage:
   •• Examples Of Hyaline cartilage:
   •• Examples of Elastin cartilage:
   •• Examples Of Fibro cartilage:
   •• Type I Collagen is found in:
   •• Which type of collagen is found in Cartilage:
   •• In Good Pasture syndrome which type of
      collagen is mutated:
A. Articular disc
B. Pinna
C. Epiphyses
D. Intervertebral disc
A. Bone
B. Cartilage
C. Tendon
   D. Ligament
                               LYMPHOID TISSUE
      •• Characterised by White pulp) and Red pulp          •• Red pulp : Remaining area in medulla , outside
                                                               the white pulp, is known as red pulp → filled
      •• In between each lymphoid follicle, one central        with RBCs.
         arteriole is present.
      •• Covered with Stratified          Non-keratinized   •• Crypta magna - Largest crypt in tonsil on the
         squamous epithelium.                                  medial side.
                                                                                             3
                                                                           Lymphoid Tissue
(FMGE 2021)
(NEET PG 2021)
        PHARYNGEAL APPARATUS – PART-1
                                                 Pharyngeal nerves:
                                                 Pharyngeal Arch              Pharyngeal nerve
                                                                                                            3
                                                                            Pharyngeal Apparatus – Part-1
    1. Treacher-Collins Syndrome
    2. Mandibulofacial Dysostosis
    1. Treacher-Collins Syndrome
      •• Mandibulofacial Dysostosis
         –– Mutation in Chromosome
         –– Mandibular Hypoplasia
                                                                                                      5
                                                                      Pharyngeal Apparatus – Part-1
  •• Ectoderm is dipping in between 2 arches known     –– 2nd arch grows rapidly & adjoins with basal
     as Pharyngeal cleft.
                                                          part. In between (includes 2nd, 3rd, 4th
  •• 1st cleft: forms External auditory canal → 6
                                                          cleft), it makes cervical sinus
     hillocks develops around 1st cleft → pinna is
     formed
    PHARYNGEAL POUCH
     •• Endodermal out bulging in between 2 arches
        known as pharyngeal pouches.
     •• total 4 in no.
     •• 1st pouch: make auditory tube (tubo + tympanic
        recess) and tympanic membrane cavity.
     •• 2nd pouch: make tonsil
Clinical :
                                                          DIGEORGE SYNDROME:
                                                            •• Features Vary Widely
                                                            •• CATCH 22
     •• 3rd pouch: dorsal part makes 2 inferior
                                                            •• Cardiac Abnormality (Interrupted Aortic Arch,
        parathyroid glands ; ventral part makes thymus.
                                                               Truncus Arteriosus, Tetralogy of Fallot)
     •• 4th pouch: dorsal part makes 2 superior
                                                            •• Abnormal Facies
        parathyroid glands ; ventral part makes lateral
        lobe of thyroid.                                    •• Thymic Aplasia
                                                            •• Cleft Palate
                                                            •• Hypocalcemia/Hypoparathyroidism
                                                            •• Velocardio-Facial   Syndrome   or   Shprintzen
                                                               Syndrome:
                                                               –– Cause: Microdeletion of chromosome 22
                                                                                                             3
                                                                             Pharyngeal Apparatus – Part-2
                                                      PYQs:
                                                      Q. Developmental Defect in Which of The Following
                                                         Structures Can Cause Tetany & Absent Thymus
                                                         Gland? (AIIMSP MAY 2017 / FMGE)
                                                         C. C
Focus Areas for Exams:
                                                         D. D
  •• Derivatives of Each Pharyngeal Cleft
  •• Derivatives of Each Pharyngeal Pouch
  •• Clinical Integration with ENT, SURGERY,
     MEDICINE & RADIOLOGY
Revision Capsule:
  •• Pharyngeal Clefts Derivative
  •• Pharyngeal Pouch Derivatives
  •• Di George’s Syndrome
                               General Embryology
Embryology –
Study of Formation, Development and Maturation of
the Embryo is known as Embryology.
Spermatogenesis & Spermiogenesis
  •• Formation of the spermatozoa or mature
     sperm from the Spermatogonium is known as
     Spermatogenesis
  •• Type A Spermatogonium cells (2n) are the
     immature cells or the stem cells giving rise to
     the same type of cells.
  •• Type B Spermatogonium cells (2n) are going
     under spermatogenesis. MCQ
  •• 1st meiotic division     occurs   in   primary
     spermatocyte (2n)
  •• Conversion of Spermatids into Mature
     Spermatozoa is known as Spermiogenesis.
2
     Anatomy
      •• Sperm head is contributed by Nucleus                4. Human Sperm Remains Fertile in Female Genital
      •• Acrosome is formed by the Golgi Apparatus              Tract For: 24- 48 hrs/ 2 days
         –– Release of hydrolytic enzymes from               5. Reproductive Life of Sperm: 24- 72 hrs [3 days]
            acrosome – degrades the outer covering of
            the ovum i.e., Zona pellucida and helps in the   6. Reproductive Life of Ovum: 12- 24 hrs [1 day]
            penetration of ovum
                                                             7. Polyspermy is Prevented by: Calcium Released by
      •• Proximal Centriole is close to the head while          Intracellular Ovum
         Distal Centriole is making the Annulus
      •• Middle piece part is made by the Mitochondria         •• Interstitial cells (of Leydig) – responsible for
                                                                  Testosterone hormone synthesis
                                                               •• Sustentacular cells (Sertoli cells) – supporting
                                                                  cells in between the spermatogonia for support
                                                                  and nutrition
Oogenesis
•• Morula – 16-cell stage (3rd day)                  •• Blastocyst – on 4th day , 32 cell stage with
•• Advanced morula : 32 cell stage without cyst >       cavity
   16 to 32 cell stage                               •• Implantation of Blastocyst – 6th day (6th –
                                                        10th/12th day)
    •• Amniotic cavity - Nutrition to the baby                  If mesoderm persists here – causes Anal
                                                                   Stenosis – Fecal material will not pass –
    •• Outer layer – Ectoderm
                                                                   requires surgery
    •• Mesoderm develops everywhere except for 2
                                                         •• Vitello – Intestinal duct
       areas –
       –– Bucco-pharyngeal membrane – forms the oral   SURGERY-ANATOMY INTEGRATION
          cavity                                       Vitello – Intestinal duct
       –– Anal membrane – forms Anal Canal                •• Remnant → Meckel’s Diverticula (2% Rule)
                                                                                                             9
                                                                                      General Embryology
  ––
2
     Anatomy
      •• The 2 corners meet together and form a tube           –– Remnant of Notochord – Nucleus Pulposus
         like structure known as Neural Tube                      (inside the IVD)
–– ↓Vitamin B9 – NTD
                                                     NCC
                                                        •• Terrorist cells – can go anywhere and do their
                                                           job
                                                        •• During embryonic development there is release
                                                           of the hyaluronic acid and creates the pathway.
                                                           Through these pathways NCC migrate to
                                                           different parts of the body
4
     Anatomy
    NCC Derivatives:
    Tricks & Magic
      •• BHU – Banaras Hindu University, founder was –
         MMM – Madan Mohan Malviya
      •• PAEDS doing DiSCo in front of MMM
        –– P- Parasympathetic ganglion
        –– E- Enteric plexus – Auerbach plexus
        –– A- ANS ganglion
        –– D- Dorsal root ganglion
        –– S- Schwann cell
        –– D- Dentine tissue[odontoblast]
        –– S- Sclera
        –– C- Choroid, connective tissue of thyroid,
           parathyroid, thymus, connective tissue of
           gland –lacrimal, nasal, oral, salivary gland,
           palatine gland.
        –– M- Melanocyte                                   Hirschsprung disease'
        –– M- Mesenchymal bone of HEAD & FACE
        –– M- Meninges
        –– Adrenal medulla
    Achalasia Cardia
      •• Hyaluronic Acid - Most abundant MPS in the
         body
        –– Absent – failure of migration of NCC
      •• At lower esophageal junction, NO is released
         → which ↑ cAMP → causing Smooth muscle
         relaxation
        –– If NCC not reaching to the lower part of the
           esophageal junction, then there is no release
           of NO → no ↑ cAMP → no smooth muscle
           relaxation → narrowing of the Lower part of
           the esophagus (Aganglionic disease)
        –– Radiology – Bird beak appearance
                                                                                                  5
                                                                               CNS Development
                                               Revision Capsule:
                                                 •• Neuralisation : 28th day
                                                 •• Anterior Neuropore Is Closed on : 25th day
                                                 •• Posterior Neuropore Is Closed on : 28th day
                                                 •• NCC Derivatives
                                                 •• Achalasia Cardia
                                                 •• Hirschsprung Disease
                                               PYQs
                                               Q. Identify The Embryological Basis Of This
                                                  Congenital Defect Shown in The Image (FMGE
                                                  Dec 2021)
                                                  D. None
Focus Areas For Exams
  •• Parts of Primitive Brain & Its Cavities
  •• Neural Tube Formation
  •• Neural Tube Defects
  •• NCC Derivatives
  •• Failure of Migration of NCC
                            CVS DEVELOPMENT
•• In the embryo, development of the heart starts        •• The development of this area will create the
   near the 3rd week of intrauterine life i.e., 21st        beginning of the formation of the heart. So this
   day                                                      area is known as the Cardiogenic area
•• Bilaminar disc where there is development of          •• Development of the heart starts near the
   intraembryonic mesoderm developing from the              pharynx
   epiblast cells and proliferating near the head           –– In case of MI/ Angina – pain can be referred
   end.                                                        to the neck area near to the left jaw
•• Ventricles will proliferate and will come forward   Mnemonic – BVAS: BV Aur Saas (kyunki saas
   and downward. Atria will go backwards and           bhi kabhi bahu thi)
   superiorly.
                                                         •• B - Bulbus cordis
•• Now the heart shows a conical structure where
   Atria is above and posteriorly – forms the base       •• V – Ventricle
   of the heart.                                         •• A – Atria
2
     Anatomy
•• S – Sinus venosus
                                                     PEDIA/MEDICINE-ANATOMY
                                                     INTEGRATION
                                                     Persistent Ductus Arteriosus leads to
1. 1st ,2nd & 5th arch arteries disappear •• Patent Ductus Arteriosus (CHD)
2. Remnant of 1st arch artery → Inferior alveolar       •• Rx – Indomethacin (PG synthesis inhibitor) is
   artery – Br. of Maxillary Artery                        given (DOC)
    Fate of aortic arches: Disappearance of 1st, 2nd and       Relationship of the Vagus and
    5th arches.                                                Recurrent Laryngeal Nerves to the
                                                               aortic arches
                                                    PYQs
                                                    Q. Development of hart starts at which marked
                                                       area (AIIMSP NOV 17)
A. A
B. B
C. C
D. D
A. 3rd arch
B. 4th arch
C. 5th arch
D. 6th arch
A. 2nd week
B. 4th week
SURGERY-ANATOMY                                           PEDIA/SURGERY-ANATOMY
INTEGRATION                                               INTEGRATION
Vitello – Intestinal duct                                 Proctodeum
                                                          Persistence of mesoderm results in
   •• Remnant – 1 opening – is Meckel’s Diverticula
      (2% Rule)                                             •• Anal Atresia
   •• 2 opening – Fecal Fistula (FMGE 2021)                 •• Anal Stenosis
  •• Mesoderm develops everywhere except for 2              •• Distal to the Allantoic diverticulum is the cloaca
     areas –                                                   which forms the Urinary Bladder and Rectum.
                                                        Vitello-Intestinal Duct
Reversed Rotation                                         •• Persist with 2 opening – Fistula
  •• Rotation of the GIT occurs not in the                •• Presence of 1 opening and another is obliterated
     Anticlockwise direction but clockwise also.             – Fecal/ Umbilicus Sinus
  •• From posterior to anterior                           •• Both ends getting obliterated and presentation
4
     Anatomy
    PATHO-ANATOMY INTEGRATION
    Meckel’s Diverticulum developing opposite to the
    mesentery – present at the Antimesenteric Border
Development of Tongue
6
    Anatomy
B. Midgut
A. Allantoic diverticula
B. Cloaca
C. Hind gut
                                                            D. Urogenital sinus
KIDNEY, MALE & FEMALE GENITAL TRACT
           DEVELOPMENT
2
     Anatomy
    PATHO/SURGERY/MEDICINE/
    PEDIA- ANATOMY INTEGRATION
    Multiple Nephron – the part of the kidney where
    there is the collection of the urine, giving rise to
    multiple structure k/a Polycystic Kidney Disease
    (PCKD)
       •• Type 1 – Chr 16 mutation
       •• Type 2 – Chr 4 mutation
                                                                                                               3
                                                             Kidney, Male & Female Genital Tract Development
•• Cloaca – distal part of the hindgut which is distal to the Alantois, responsible for the formation of the
   Urinary Bladder, Rectum and Anal canal.
Vagina Development