Lawrence Bragg
Lawrence Bragg
Bragg in 1915
the autumn of 1909 and received a major scholarship       Father         William Henry Bragg
in mathematics, despite taking the exam while in bed
with pneumonia. After initially excelling in                 Relatives         Charles Todd (grandfather)
mathematics, he transferred to the physics course in the     Awards            Matteucci Medal (1915)
later years of his studies, and graduated with first class
                                                                               Barnard Medal for Meritorious
honours in 1911. In 1914 Bragg was elected to a
                                                                               Service to Science (1915)
Fellowship at Trinity College – a Fellowship at a
                                                                               Nobel Prize in Physics (1915)
Cambridge college involves the submission and
defence of a thesis.[8][9]                                                     FRS (1921)[1]
                                                                               Hughes Medal (1931)
Among Bragg's other interests was shell collecting; his
                                                                               Dalton Medal (1942)
personal collection amounted to specimens from some
                                                                               International membership of
500 species; all personally collected from South
                                                                               NAS (1945)
Australia. He discovered a new species of cuttlefish –
Sepia braggi, named for him by Joseph Verco.[10]                               Royal Medal (1946)
                                                                               Roebling Medal (1948)
                                                                               Copley Medal (1966)
Career
                                                                             Scientific career
                                                             Fields            Physics
X-rays and the Bragg equation
                                                             Institutions      University of Adelaide
The composition of X-rays was unknown, his father
argued that X-rays are streams of particles, others                            University of Manchester
argued that they are waves. Max von Laue directed an                           University of Cambridge
X-ray beam at a crystal in front of a photographic           Academic          J. J. Thomson
plate; alongside of the spot where the beam struck           advisors          William Henry Bragg
there were additional spots from deflected rays – hence
                                                             Doctoral          John Crank
X-rays are waves.[11] In 1912, as a first-year research
                                                             students          Ronald Wilfred Gurney
student at Cambridge, W. L. Bragg, while strolling by
the river, had the insight that crystals made from                             Alex Stokes[2]
parallel sheets of atoms would not diffract X-ray                              Samuel Tolansky
beams that struck their surface at most angles because                         Evan James Williams[3]
X-rays deflected by collisions with atoms would be out
of phase, cancelling one another out. However, when          Other notable     William Cochran
the X-ray beam struck at an angle at which the               students
distances it passed between atomic sheets in the crystal         5th Cavendish Professor of Physics
equalled the X-ray's wavelength then those deflected                            In office
would be in phase and produce a spot on a nearby film.                         1938–1953
From this insight he wrote the simple Bragg equation
                                                             Preceded by       J. J. Thomson
that relates the wavelength of the X-ray and the
distance between atomic sheets in a simple crystal to        Succeeded by Nevill Francis Mott
the angles at which an impinging X-ray beam would be               3rd Director of National Physical
reflected.                                                                    Laboratory
                                                                                In office
His father built an apparatus in which a crystal could                         1937–1938
be rotated to precise angles while measuring the energy Preceded by Frank Edward Smith (acting)
of reflections. This enabled father and son to measure
                                                        Succeeded by Charles Galton Darwin
the distances between the atomic sheets in a number of
simple crystals. They calculated the spacing of the
atoms from the weight of the crystal and the Avogadro constant, which enabled them to measure the
wavelengths of the X-rays produced by different metallic targets
in the X-ray tubes. W. H. Bragg reported their results at meetings
and in a paper, giving credit to "his son" (unnamed) for the
equation, but not as a co-author, which gave his son "some
heartaches", which he never overcame.[12]
Hot wire sound ranging was used in World War II during which he served as a civilian adviser.[23]
Between the wars, from 1919 to 1937, he worked at the Victoria University of Manchester as Langworthy
Professor of Physics. He became the director of the National Physical Laboratory in Teddington in
1937.[24]
After World War II, Bragg returned to Cambridge, splitting the Cavendish Laboratory into research
groups. He believed that "the ideal research unit is one of six to twelve scientists and a few assistants".
During the war the Cavendish offered a shortened graduate course which emphasised the electronics
needed for radar. Bragg worked on the structure of metals and consulted on sonar and sound ranging, for
which the Tucker microphone was still used. Bragg was knighted and became Sir Lawrence in 1941.
After his father died in 1942, Bragg served for six months as Scientific Liaison Officer to Canada. He
also organised periodic conferences on X-ray analysis, which was widely used in military research.
After the war Bragg led in the formation of the International Union of Crystallography and was elected its
first president. He reorganised the Cavendish into units to reflect his conviction that "the ideal research
unit is one of six to twelve scientists and a few assistants, helped by one or more first-class instrument
mechanics and a workshop in which the general run of apparatus can be constructed."[26] Senior members
of staff now had offices, telephones, and secretarial support. The scope of the department was enlarged
with a new unit on radio astronomy. Bragg's own work focused on the structure of metals, using both X-
rays and the electron microscope. In 1947 he persuaded the Medical Research Council (MRC) to support
what he described as the "gallant attempt"[27] to determine protein structure as the Laboratory of
Molecular Biology, initially consisting of Perutz, John Kendrew and two assistants. Bragg worked with
them and by 1960 they had resolved the structure of myoglobin to the atomic level.[28] After this Bragg
was less involved; their analysis of haemoglobin was easier after they incorporated two mercury atoms as
markers in each molecule. The first monumental triumph of the MRC was decoding the structure of DNA
by James Watson and Francis Crick. Bragg announced the discovery at a Solvay conference on proteins
in Belgium on 8 April 1953, though it went unreported by the press. He then gave a talk at Guy's Hospital
Medical School in London on Thursday, 14 May 1953, which resulted in an article by Ritchie Calder in
the News Chronicle of London on Friday, 15 May 1953, entitled "Why You Are You. Nearer Secret of
Life". Bragg nominated Crick, Watson and Maurice Wilkins for the 1962 Nobel Prize in Physiology or
Medicine; Wilkins' share recognised the contribution of X-ray crystallographers at King's College
London.[29] Among them was Rosalind Franklin, whose "photograph 51" showed that DNA was a double
helix, not the triple helix that Linus Pauling had proposed. Franklin died before the prize (which only
goes to living people) was awarded.
He continued research in the Institution by recruiting a small group to work in the Davy-Faraday
Laboratory in the basement and in the adjoining house, supported by grants he obtained. A visitor to the
laboratory succeeded in inserting heavy metals into the enzyme lysozyme; the structure of its crystal was
solved in 1965 at the Royal Institution by D. C. Phillips and his coworkers, with the computations on the
9,040 reflections performed on the digital computer at the University of London, which greatly facilitated
the work.[32] Two of the illustrations of the positioning of amino acids in the chain were drawn by Bragg.
Unlike myoglobin, in which nearly 80 per cent of the amino-acid residues are in the alpha-helix
conformation, in lysozyme the alpha-helix content is only about 40 per cent of the amino-acid residues
found in four main stretches. Other stretches are of the 310 helix, a conformation that they had proposed
earlier.[33] In this conformation, every third peptide is hydrogen-bonded back to the first peptide, thus
forming a ring containing ten atoms. They had the complete structure of an enzyme in time for Bragg's
75th birthday. He became Professor Emeritus in 1966.
X-ray analysis of protein structure flourished in subsequent years, determining the structures of scores of
proteins in laboratories around the world. Twenty eight Nobel Prizes have been awarded for work using
X-ray analysis. The disadvantage of the method is that it must be done on crystals, which precludes
seeing changes in shape when enzymes bind substrates and the like. This problem was solved by the
development of another line Bragg had initiated, using modified electron microscopes to image single
frozen molecules: cryo-electron microscopy.[34]
Personal life
In 1921 he married Alice Hopkinson (1899–1989), a cousin of a Cecil Hopkinson (1891–1917) who
shared rooms with Bragg, and was one of his closest friends whilst they were both studying at
Cambridge.[35][36] Cecil was the son of John Hopkinson who was Alice's uncle.
They had four children, the engineer Stephen Lawrence (1923–2014), David William (1926–2005),
Margaret Alice (1931–2022) (who married the diplomat Mark Heath), and Patience Mary (1935–2020)
(who married David, the son of Sir George Thomson the Nobel prize winning physicist[37]). Alice was on
the staff at Withington Girls' School until Bragg was appointed director of the National Physical
Laboratory in 1937.[24] She was active in a number of public bodies and served as Mayor of Cambridge
from 1945 to 1946.
Bragg's hobbies included drawing – family letters were illustrated with lively sketches – painting,
literature and a lifelong interest in gardening.[38] When he moved to London, he missed having a garden
and so worked as a part-time gardener, unrecognised by his employer, until a guest at the house expressed
surprise at seeing him there.[39] He died at a hospital near his home at Waldringfield, Ipswich, Suffolk.
He was buried in Trinity College, Cambridge; his son David is buried in the Parish of the Ascension
Burial Ground in Cambridge, his grave is within a few paces of that of Bragg's close friend, Rudolph
Cecil Hopkinson, who incurred a severe head wound in the 1914–19 war and died a few months after
being invalided back to the UK.[37]
In August 2013, Bragg's relative, the broadcaster Melvyn Bragg, presented a BBC Radio 4 programme
("Bragg on the Braggs") on the 1915 Nobel Prize in Physics winners.[40][41]
See also
   List of Nobel laureates in Physics
   Tactical artillery terms from World War I
   Tube Alloys
References
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15. Van der Kloot 2014, pp. 129–161.
16. "Casualty Details: Bragg, Robert Charles" (http://www.cwgc.org/find-war-dead/casualty/6807
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23. Van der Kloot 2014, pp. 207–208.
24. Newsletter 1936–1937. Withington Girls' School. 1937.
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26. Phillips 1979, p. 117.
27. Phillips 1979, p.118
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    3%2FPT.3.3270). Retrieved 7 December 2024.
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    Retrieved 7 December 2024.
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    0140119732.
40. "Bragg on the Braggs" (https://www.leeds.ac.uk/forstaff/news/article/4011/bragg_on_the_bra
    ggs). 2 March 2017.
41. "BBC Radio 4 - Bragg on the Braggs" (https://www.bbc.co.uk/programmes/b0383vb0).
42. G. K. Hunter 2004 Light is a Messenger Oxford: OUP.
43. "No. 35029" (https://www.thegazette.co.uk/London/issue/35029/supplement/1). The London
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44. "No. 44210" (https://www.thegazette.co.uk/London/issue/44210/supplement/26). The
    London Gazette (Supplement). 30 December 1966. p. 26. CH
45. Bragg Gold Medal for Excellence in Physics (http://www.aip.org.au/info/?q=content/bragg-go
    ld-medal-excellence-physics) Archived (https://web.archive.org/web/20140714133644/http://
    www.aip.org.au/info/?q=content%2Fbragg-gold-medal-excellence-physics) 14 July 2014 at
    the Wayback Machine
Further reading
   Hunter, Graeme (2004). Light Is A Messenger, the Life and Science of William Lawrence
   Bragg. Oxford: Oxford University Press. ISBN 0-19-852921-X.
   Finch, John (2008). A Nobel Fellow On Every Floor. Medical Research Council. ISBN 978-1-
   84046-940-0. (This book is about the MRC Laboratory of Molecular Biology, Cambridge.)
   Ridley, Matt (2006). Francis Crick: Discoverer of the Genetic Code. Eminent Lives.
   HarperCollins. ISBN 0-06-082333-X.
   Jenkin, John (2008). William and Lawrence Bragg, Father and Son: The Most Extraordinary
   Collaboration in Science. Oxford: Oxford University Press.
External links
      Media related to William Lawrence Bragg at Wikimedia Commons
   First press stories on DNA (https://web.archive.org/web/20060618160456/http://www.packer
   34.freeserve.co.uk/selectedTATAwebsites.htm)
    Nobelprize.org – The Nobel Prize for Physics in 1915 (http://nobelprize.org/nobel_prizes/phy
    sics/laureates/1915/index.html)
    Lawrence Bragg (https://www.nobelprize.org/laureate/21) on Nobelprize.org including the
    Nobel Lecture, September 6, 1922 The Diffraction of X-Rays by Crystals
    A collection (http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/bond/people/bra
    gg.html) of digitised materials related to Bragg's and Linus Pauling's structural chemistry
    research.
    Key Participants: Sir William Lawrence Bragg (http://scarc.library.oregonstate.edu/coll/paulin
    g/dna/people/bragg.html) – Linus Pauling and the Race for DNA: A Documentary History
    NOVA Episode on Photograph 51 (https://www.pbs.org/wgbh/nova/photo51/)
    Oral History interview transcript with William Lawrence Bragg on 20 June 1969, American
    Institute of Physics, Niels Bohr Library and Archives (https://www.aip.org/history-programs/ni
    els-bohr-library/oral-histories/28531)
    Bragg, Lawrence (Sir) (1890–1971) (http://nla.gov.au/nla.party-458785) National Library of
    Australia, Trove, People and Organisation record for William Lawrence Bragg
    The Nature of Things: Oil, Soap and Detergent (http://richannel.org/the-nature-of-things--oil-
    soap-and-detergent), Ri Channel video, November 1959
    The Nature of Things: Atoms and Molecules (http://www.richannel.org/the-nature-of-things--
    atoms-and-molecules), Ri Channel video, October 1959
    The Nature of Things: Solids, Liquids and Gases (http://www.richannel.org/the-nature-of-thin
    gs--solids-liquids-and-gases), Ri Channel video, November 1959
    Portraits of Lawrence Bragg (https://www.npg.org.uk/collections/search/person.php?LinkID=
    mp19002) at the National Portrait Gallery, London