0% found this document useful (0 votes)
7 views1 page

Cancer DR 53-53

Uploaded by

havadese.tarikhi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
0% found this document useful (0 votes)
7 views1 page

Cancer DR 53-53

Uploaded by

havadese.tarikhi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 1

Chemical Reviews pubs.acs.

org/CR Review

Desirable Mechanistic and Pre-Clinical DMPK Attributes. Cancer Res. Mutant Lung Cancers: Results From a Phase II Basket Trial. J. Clin.
2019, 79, P5-04-07. Oncol. 2018, 36, 2532−2537.
(301) Bardia, A.; Linden, H. M.; Ulaner, G. A.; Chandarlapaty, S.; (317) Tsurutani, J.; Park, H.; Doi, T.; Modi, S.; Takahashi, S.;
Gosselin, A.; Doroumian, S.; Celanovic, M.; Campone, M. Dose- Nakagawa, K.; Krop, I.; Waqar, S.; Yoh, K.; Li, B.; et al. Updated
Escalation Study of SAR439859, an Oral Selective Estrogen Receptor Results of Phase 1 Study of DS-8201a in HER2-Expressing or −
(ER) Degrader (SERD), in Postmenopausal Women with ER Mutated Advanced Non-Small-Cell Lung Cancer. J. Thorac. Oncol.
+/HER2- Metastatic Breast Cancer (mBC). J. Clin. Oncol. 2019, 37, 2018, 13, S324.
1054. (318) Morin-Ben Abdallah, S.; Wong, A. Brain Metastases in Non-
(302) Jhaveri, K.; Juric, D.; Cresta, S.; Yap, Y.-S.; Duhoux, F. P.; Small-Cell Lung Cancer: Are Tyrosine Kinase Inhibitors and
Terret, C.; Layman, R.; Kundamal, N.; Liao, S.; Ji, Y. A phase 1/1b Checkpoint Inhibitors Now Viable Options? Curr. Oncol 2018, 25,
study of LSZ102, an oral selective estrogen receptor degrader S103−S114.
(SERD), in combination with ribociclib in patients with estrogen (319) Kancha, R. K.; von Bubnoff, N.; Bartosch, N.; Peschel, C.;
receptor-positive (ER+) advanced breast cancer (ABC) who had Engh, R. A.; Duyster, J. Differential Sensitivity of ERBB2 Kinase
progressed after endocrine therapy (ET). Cancer Res. 2020, 80, PD7- Domain Mutations Towards Lapatinib. PLoS One 2011, 6, e26760.
09. (320) Hanker, A. B.; Brewer, M. R.; Sheehan, J. H.; Koch, J. P.;
(303) Wang, L.; Guillen, V. S.; Sharma, N.; Flessa, K.; Min, J.; Sliwoski, G. R.; Nagy, R.; Lanman, R.; Berger, M. F.; Hyman, D. M.;
Carlson, K. E.; Toy, W.; Braqi, S.; Katzenellenbogen, B. S.; Solit, D. B.; et al. An Acquired HER2T798I Gatekeeper Mutation
Katzenellenbogen, J. A.; et al. New Class of Selective Estrogen Induces Resistance to Neratinib in a Patient with HER2Mutant−
Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Driven Breast Cancer. Cancer Discovery 2017, 7, 575−585.
Degrons. ACS Med. Chem. Lett. 2018, 9, 803−808. (321) Meric-Bernstam, F.; Beeram, M.; Mayordomo, J. I.; Hanna, D.
(304) Scheepstra, M.; Hekking, K. F. W.; van Hijfte, L.; Folmer, R. L.; Ajani, J. A.; Blum Murphy, M. A.; Murthy, R. K.; Piha-Paul, S. A.;
H. A. Bivalent Ligands for Protein Degradation in Drug Discovery. Bauer, T. M.; Bendell, J. C.; et al. Single Agent Activity of ZW25, a
Comput. Struct. Biotechnol. J. 2019, 17, 160−176. HER2-Targeted Bispecific Antibody, in Heavily Pretreated HER2-
(305) Meric-Bernstam, F.; Johnson, A. M.; Dumbrava, E. E. I.; Expressing Cancers. J. Clin. Oncol. 2018, 36, 2500.
Raghav, K.; Balaji, K.; Bhatt, M.; Murthy, R. K.; Rodon, J.; Piha-Paul, (322) Baird, R.; Omlin, A.; Kiemle-Kallee, J.; Fiedler, U.; Zitt, C.;
S. A. Advances in HER2-Targeted Therapy: Novel Agents and Feurstein, D.; Herbst, J.; Dawson, K.; vom Baur, E.; Stumpp, M.; et al.
Opportunities Beyond Breast and Gastric Cancer. Clin. Cancer Res. MP0274-CP101: A Phase 1, First-In-Human, Single-Arm, Multi-
2019, 25 (7), 2033−2041. Center, Open-Label, Dose Escalation Study to Assess Safety,
(306) Gajria, D.; Chandarlapaty, S. HER2-Amplified Breast Cancer: Tolerability, and Pharmacokinetics of MP0274 in Patients with
Mechanisms of Trastuzumab Resistance and Novel Targeted Advanced HER2-Positive Solid Tumors. Cancer Res. 2018, 78, OT1-
Therapies. Expert Rev. Anticancer Ther. 2011, 11, 263−275.
03-02.
(307) FDA Approves Trastuzumab Biosimilar. Cancer Discovery
(323) Murthy, R. K.; Loi, S.; Okines, A.; Paplomata, E.; Hamilton,
2018, 8, 130.2..
E.; Hurvitz, S. A.; Lin, N. U.; Borges, V.; Abramson, V.; Anders, C.;
(308) Chen, S.; Liang, Y.; Feng, Z.; Wang, M. Efficacy and Safety of
et al. Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive
HER2 Inhibitors in Combination With or Without Pertuzumab for
Metastatic Breast Cancer. N. Engl. J. Med. 2020, 382, 597−609.
HER2-Positive Breast Cancer: A Systematic Review and Meta-
(324) Dang, L.; White, D. W.; Gross, S.; Bennett, B. D.; Bittinger, M.
Analysis. BMC Cancer 2019, 19, 973.
A.; Driggers, E. M.; Fantin, V. R.; Jang, H. G.; Jin, S.; Keenan, M. C.;
(309) Nakada, T.; Sugihara, K.; Jikoh, T.; Abe, Y.; Agatsuma, T. The
Latest Research and Development into the Antibody−Drug et al. Cancer-Associated IDH1Mutations Produce 2-Hydroxygluta-
Conjugate, [fam-] Trastuzumab Deruxtecan (DS-8201a), for HER2 rate. Nature 2009, 462, 739−744.
Cancer Therapy. Chem. Pharm. Bull. 2019, 67, 173−185. (325) Popovici-Muller, J.; Lemieux, R. M.; Artin, E.; Saunders, J. O.;
(310) Rinnerthaler, G.; Gampenrieder, S. P.; Greil, R. HER2 Salituro, F. G.; Travins, J.; Cianchetta, G.; Cai, Z.; Zhou, D.; Cui, D.;
Directed Antibody-Drug-Conjugates beyond T-DM1 in Breast et al. Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant
Cancer. Int. J. Mol. Sci. 2019, 20, 1115−1132. IDH1 Inhibitor for the Treatment of IDH1Mutant Cancers. ACS
(311) Rusnak, D. W.; Lackey, K.; Affleck, K.; Wood, E. R.; Alligood, Med. Chem. Lett. 2018, 9, 300−305.
K. J.; Rhodes, N.; Keith, B. R.; Murray, D. M.; Knight, W. B.; Mullin, (326) Yen, K.; Travins, J.; Wang, F.; David, M. D.; Artin, E.; Straley,
R. J.; et al. The Effects of the Novel, Reversible Epidermal Growth K.; Padyana, A.; Gross, S.; DeLaBarre, B.; Tobin, E.; et al. AG-221, a
Factor Receptor/ErbB-2 Tyrosine Kinase Inhibitor, GW2016, on the First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring
Growth of Human Normal and Tumor-Derived Cell Lines In Vitro Oncogenic IDH2Mutations. Cancer Discovery 2017, 7, 478−493.
and In Vivo. Mol. Cancer Ther. 2001, 1, 85−94. (327) Intlekofer, A. M.; Shih, A. H.; Wang, B.; Nazir, A.;
(312) Tsang, R. Y.; Sadeghi, S.; Finn, R. S. Lapatinib, a Dual- Rustenburg, A. S.; Albanese, S. K.; Patel, M.; Famulare, C.; Correa,
Targeted Small Molecule Inhibitor of EGFR and HER2, in HER2- F. M.; Takemoto, N.; et al. Acquired Resistance to IDH Inhibition
Amplified Breast Cancer: From Bench to Bedside. Clin. Med. Insights: Through Trans or Cis Dimer-Interface Mutations. Nature 2018, 559,
Ther. 2011, 3, CMT.S3783. 125−129.
(313) Tonge, P. J. Drug-Target Kinetics in Drug Discovery. ACS (328) Harding, J. J.; Lowery, M. A.; Shih, A. H.; Schvartzman, J. M.;
Chem. Neurosci. 2018, 9, 29−39. Hou, S.; Famulare, C.; Patel, M.; Roshal, M.; Do, R. K.; Zehir, A.;
(314) Xia, W.; Mullin, R. J.; Keith, B. R.; Liu, L.-H.; Ma, H.; Rusnak, et al. Isoform Switching as a Mechanism of Acquired Resistance to
D. W.; Owens, G.; Alligood, K. J.; Spector, N. L.; et al. Anti-tumor Mutant Isocitrate Dehydrogenase Inhibition. Cancer Discovery 2018,
Activity of GW572016: A Dual Tyrosine Kinase Inhibitor Blocks EGF 8, 1540−1547.
Activation of EGFR/erbB2 and Downstream Erk1/2 and AKT (329) Golub, D.; Iyengar, N.; Dogra, S.; Wong, T.; Bready, D.;
Pathways. Oncogene 2002, 21, 6255−63. Tang, K.; Modrek, A. S.; Placantonakis, D. G. Mutant Isocitrate
(315) Mazieres, J.; Peters, S.; Lepage, B.; Cortot, A. B.; Barlesi, F.; Dehydrogenase Inhibitors as Targeted Cancer Therapeutics. Front.
Beau-Faller, M.; Besse, B.; Blons, H.; Mansuet-Lupo, A.; Urban, T.; Oncol. 2019, 9, 417.
et al. Lung Cancer that Harbors an HER2Mutation: Epidemiologic (330) Ma, R.; Yun, C. H. Crystal structures of pan-IDH inhibitor
Characteristics and Therapeutic Perspectives. J. Clin. Oncol. 2013, 31, AG-881 in complex with mutant human IDH1 and IDH2. Biochem.
1997−2003. Biophys. Res. Commun. 2018, 503, 2912−2917.
(316) Li, B. T.; Shen, R.; Buonocore, D.; Olah, Z. T.; Ni, A.; (331) Cho, Y. S.; Levell, J. R.; Liu, G.; Caferro, T.; Sutton, J.; Shafer,
Ginsberg, M. S.; Ulaner, G. A.; Offin, M.; Feldman, D.; Hembrough, C. M.; Costales, A.; Manning, J. R.; Zhao, Q.; Sendzik, M.; et al.
T.; et al. Ado-Trastuzumab Emtansine for Patients With HER2- Discovery and Evaluation of Clinical Candidate IDH305, a Brain

BA https://dx.doi.org/10.1021/acs.chemrev.0c00383
Chem. Rev. XXXX, XXX, XXX−XXX

You might also like