0% found this document useful (0 votes)
8 views1 page

cdk9 20-20

Uploaded by

havadese.tarikhi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
0% found this document useful (0 votes)
8 views1 page

cdk9 20-20

Uploaded by

havadese.tarikhi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 1

Anshabo et al.

CDK9 in Cancer

Promotes Progression to S Phase. J Biol Chem (2008) 283(14):9040–8. B) in Cardiac Muscle-Cell Hypertrophy. Nat Med (2002) 8(11):1310–7.
doi: 10.1074/jbc.M707603200 doi: 10.1038/nm778
65. Foskett SM, Ghose R, Tang DN, Lewis DE, Rice AP. Antiapoptotic Function 84. He N, Jahchan NS, Hong E, Li Q, Bayfield MA, Maraia RJ, et al. A La-related
of Cdk9 (Tak/P-TEFb) in U937 Promonocytic Cells. J Virol (2001) 75 Protein Modulates 7SK snRNP Integrity to Suppress P-TEFb-dependent
(3):1220–8. doi: 10.1128/JVI.75.3.1220-1228.2001 Transcriptional Elongation and Tumorigenesis. Mol Cell (2008) 29(5):588–
66. Simone C, Stiegler P, Bagella L, Pucci B, Bellan C, De Falco G, et al. 99. doi: 10.1016/j.molcel.2008.01.003
Activation of MyoD-dependent Transcription by cdk9/cyclin T2. Oncogene 85. Barboric M, Lenasi T, Chen H, Johansen EB, Guo S, Peterlin BM. 7sk
(2002) 21(26):4137–48. doi: 10.1038/sj.onc.1205493 snRNP/P-TEFb Couples Transcription Elongation With Alternative Splicing
67. Nojima M, Huang Y, Tyagi M, Kao HY, Fujinaga K. The Positive and is Essential for Vertebrate Development. Proc Natl Acad Sci USA (2009)
Transcription Elongation Factor B is an Essential Cofactor for the 106(19):7798–803. doi: 10.1073/pnas.0903188106
Activation of Transcription by Myocyte Enhancer Factor 2. J Mol Biol 86. Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, et al. Systematic
(2008) 382(2):275–87. doi: 10.1016/j.jmb.2008.07.017 Analysis of the Protein Interaction Network for the Human Transcription
68. Bellan C, De Falco G, Lazzi S, Micheli P, Vicidomini S, Schurfeld K, et al. Machinery Reveals the Identity of the 7SK Capping Enzyme. Mol Cell (2007)
Cdk9/Cyclin T1 Expression During Normal Lymphoid Differentiation and 27(2):262–74. doi: 10.1016/j.molcel.2007.06.027
Malignant Transformation. J Pathol (2004) 203(4):946–52. doi: 10.1002/ 87. Blazek D, Barboric M, Kohoutek J, Oven I, Peterlin BM. Oligomerization of
path.1588 HEXIM1 Via 7SK snRNA and Coiled-Coil Region Directs the Inhibition of
69. De Falco G, Bellan C, D’Amuri A, Angeloni G, Leucci E, Giordano A, et al. P-Tefb. Nucleic Acids Res (2005) 33(22):7000–10. doi: 10.1093/nar/gki997
Cdk9 Regulates Neural Differentiation and its Expression Correlates With 88. Li Q, Price JP, Byers SA, Cheng D, Peng J, Price DH. Analysis of the Large
the Differentiation Grade of Neuroblastoma and PNET Tumors. Cancer Biol Inactive P-TEFb Complex Indicates That it Contains One 7SK Molecule, a
Ther (2005) 4(3):277–81. doi: 10.4161/cbt.4.3.1497 Dimer of HEXIM1 or HEXIM2, and Two P-TEFb Molecules Containing
70. Herrmann CH, Carroll RG, Wei P, Jones KA, Rice AP. Tat-Associated Cdk9 Phosphorylated At Threonine 186. J Biol Chem (2005) 280(31):28819–
Kinase, TAK, Activity is Regulated by Distinct Mechanisms in Peripheral 26. doi: 10.1074/jbc.M502712200
Blood Lymphocytes and Promonocytic Cell Lines. J Virol (1998) 72 89. Barboric M, Kohoutek J, Price JP, Blazek D, Price DH, Peterlin BM. Interplay
(12):9881–8. doi: 10.1128/JVI.72.12.9881-9888.1998 Between 7SK snRNA and Oppositely Charged Regions in HEXIM1 Direct
71. Iankova I, Petersen RK, Annicotte JS, Chavey C, Hansen JB, Kratchmarova I, the Inhibition of P-Tefb. EMBO J (2005) 24(24):4291–303. doi: 10.1038/
et al. Peroxisome Proliferator-Activated Receptor Gamma Recruits the sj.emboj.7600883
Positive Transcription Elongation Factor B Complex to Activate 90. Egloff S, Van Herreweghe E, Kiss T. Regulation of Polymerase II
Transcription and Promote Adipogenesis. Mol Endocrinol (2006) 20 Transcription by 7SK snRNA: Two Distinct RNA Elements Direct P-
(7):1494–505. doi: 10.1210/me.2005-0222 TEFb and HEXIM1 Binding. Mol Cell Biol (2006) 26(2):630–42.
72. Ghosh K, Tang M, Kumari N, Nandy A, Basu S, Mall DP, et al. Positive doi: 10.1128/MCB.26.2.630-642.2006
Regulation of Transcription by Human ZMYND8 Through Its Association 91. Kobbi L, Demey-Thomas E, Braye F, Proux F, Kolesnikova O, Vinh J, et al.
With P-TEFb Complex. Cell Rep (2018) 24(8):2141–54.e6. doi: 10.1016/ An Evolutionary Conserved Hexim1 Peptide Binds to the Cdk9 Catalytic
j.celrep.2018.07.064 Site to Inhibit P-Tefb. Proc Natl Acad Sci USA (2016) 113(45):12721–6.
73. Shore SM, Byers SA, Maury W, Price DH. Identification of a Novel Isoform doi: 10.1073/pnas.1612331113
of Cdk9. Gene (2003) 307:175–82. doi: 10.1016/s0378-1119(03)00466-9 92. Chen R, Yang Z, Zhou Q. Phosphorylated Positive Transcription
74. Lin X, Taube R, Fujinaga K, Peterlin BM. P-TEFb Containing Cyclin K and Elongation Factor B (P-TEFb) is Tagged for Inhibition Through
Cdk9 can Activate Transcription Via RNA. J Biol Chem (2002) 277 Association With 7SK Snrna. J Biol Chem (2004) 279(6):4153–60.
(19):16873–8. doi: 10.1074/jbc.M200117200 doi: 10.1074/jbc.M310044200
75. Mori T, Anazawa Y, Matsui K, Fukuda S, Nakamura Y, Arakawa H. Cyclin K 93. Biglione S, Byers SA, Price JP, Nguyen VT, Bensaude O, Price DH, et al.
as a Direct Transcriptional Target of the p53 Tumor Suppressor. Neoplasia Inhibition of HIV-1 Replication by P-TEFb Inhibitors DRB, Seliciclib and
(2002) 4(3):268–74. doi: 10.1038/sj.neo.7900235 Flavopiridol Correlates With Release of Free P-TEFb From the Large,
76. Yu DS, Zhao R, Hsu EL, Cayer J, Ye F, Guo Y, et al. Cyclin-Dependent Inactive Form of the Complex. Retrovirology (2007) 4:47. doi: 10.1186/
Kinase 9-Cyclin K Functions in the Replication Stress Response. EMBO Rep 1742-4690-4-47
(2010) 11(11):876–82. doi: 10.1038/embor.2010.153 94. D’Orso I, Frankel AD. RNA-Mediated Displacement of an Inhibitory snRNP
77. Liu H, Herrmann CH, Chiang K, Sung TL, Moon SH, Donehower LA, et al. Complex Activates Transcription Elongation. Nat Struct Mol Biol (2010) 17
55K Isoform of CDK9 Associates With Ku70 and is Involved in DNA (7):815–21. doi: 10.1038/nsmb.1827
Repair. Biochem Biophys Res Commun (2010) 397(2):245–50. doi: 10.1016/ 95. Liu W, Ma Q, Wong K, Li W, Ohgi K, Zhang J, et al. Brd4 and JMJD6-
j.bbrc.2010.05.092 associated Anti-Pause Enhancers in Regulation of Transcriptional Pause
78. Michels AA, Fraldi A, Li Q, Adamson TE, Bonnet F, Nguyen VT, et al. Release. Cell (2013) 155(7):1581–95. doi: 10.1016/j.cell.2013.10.056
Binding of the 7SK snRNA Turns the HEXIM1 Protein Into a P-TEFb 96. McNamara RP, McCann JL, Gudipaty SA, D’Orso I. Transcription Factors
(CDK9/Cyclin T) Inhibitor. EMBO J (2004) 23(13):2608–19. doi: 10.1038/ Mediate the Enzymatic Disassembly of Promoter-Bound 7SK snRNP to
sj.emboj.7600275 Locally Recruit P-TEFb for Transcription Elongation. Cell Rep (2013) 5
79. Nguyen VT, Kiss T, Michels AA, Bensaude O. 7SK Small Nuclear RNA (5):1256–68. doi: 10.1016/j.celrep.2013.11.003
Binds to and Inhibits the Activity of CDK9/Cyclin T Complexes. Nature 97. Fujinaga K, Barboric M, Li Q, Luo Z, Price DH, Peterlin BM. PKC
(2001) 414(6861):322–5. doi: 10.1038/35104581 Phosphorylates HEXIM1 and Regulates P-TEFb Activity. Nucleic Acids
80. Turano M, Napolitano G, Dulac C, Majello B, Bensaude O, Lania L. Increased Res (2012) 40(18):9160–70. doi: 10.1093/nar/gks682
HEXIM1 Expression During Erythroleukemia and Neuroblastoma Cell 98. Kim YK, Mbonye U, Hokello J, Karn J. T-Cell Receptor Signaling Enhances
Differentiation. J Cell Physiol (2006) 206(3):603–10. doi: 10.1002/jcp.20502 Transcriptional Elongation From Latent HIV Proviruses by Activating P-
81. Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, et al. TEFb Through an ERK-dependent Pathway. J Mol Biol (2011) 410(5):896–
MAQ1 and 7SK RNA Interact With CDK9/Cyclin T Complexes in a 916. doi: 10.1016/j.jmb.2011.03.054
Transcription-Dependent Manner. Mol Cell Biol (2003) 23(14):4859–69. 99. Contreras X, Barboric M, Lenasi T, Peterlin BM. HMBA Releases P-TEFb
doi: 10.1128/mcb.23.14.4859-4869.2003 From HEXIM1 and 7SK snRNA Via PI3K/Akt and Activates HIV
82. Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q. Inhibition of P- Transcription. PloS Pathog (2007) 3(10):1459–69. doi: 10.1371/
TEFb (Cdk9/Cyclin T) Kinase and RNA Polymerase II Transcription by the journal.ppat.0030146
Coordinated Actions of HEXIM1 and 7SK Snrna. Mol Cell (2003) 12(4):971– 100. Chen R, Liu M, Li H, Xue Y, Ramey WN, He N, et al. PP2B and PP1alpha
82. doi: 10.1016/s1097-2765(03)00388-5 Cooperatively Disrupt 7SK snRNP to Release P-TEFb for Transcription in
83. Sano M, Abdellatif M, Oh H, Xie M, Bagella L, Giordano A, et al. Activation Response to Ca2+ Signaling. Genes Dev (2008) 22(10):1356–68. doi: 10.1101/
and Function of Cyclin T-Cdk9 (Positive Transcription Elongation Factor- gad.1636008

Frontiers in Oncology | www.frontiersin.org 20 May 2021 | Volume 11 | Article 678559

You might also like