Gaetano T.

Montelione
Gaetano T. Montelione is an American biophysical
chemist, Professor of Chemistry and Chemical Gaetano T. Montelione
Biology, and Constellation Endowed Chair in
Structural Bioinformatics at Rensselaer Polytechnic
Institute in Troy, NY.[1]

His research program includes work on Nuclear

Magnetic Resonance (NMR) pulse sequence
development, software for automated analysis of
protein NMR data, and applications of structural
bioinformatics in biomedical research.[2]

Background and education

Gaetano Montelione was born in the Bronx, NY. He
graduated from Half Hollow Hills High School in Dix
Hills, NY. He received a B.S. with Highest Honors in
Biochemistry from Cornell University in Ithaca, NY, Born Bronx, New York
and completed a Ph.D. in Physical Chemistry at Education B.S.in Biochemistry (Cornell
Cornell University under the joint mentorship of University)
Harold A. Scheraga (Cornell) and Kurt Wüthrich (ETH M.A., Ph.D. in Physical Chemistry
- Zürich). (Cornell University)
Scientific career
Montelione carried out post-doctoral research in
protein NMR pulse sequence development in the Fields Molecular Biophysics, Structural
laboratory of Gerhard Wagner in the Biophysics Biology
Research Division at the University of Michigan, Ann
Arbor.

He subsequently joined the faculty of the Department of Molecular Biology and Biochemistry[3] at
Rutgers University (New Brunswick, NJ), and the Rutgers Center for Advanced Biotechnology and
Medicine (Piscataway, NJ), directed by Aaron Shatkin. He was promoted to the rank of Distinguished
Professor and appointed as the inaugural holder of the endowed Jerome and Lorraine Aresty Chair in
Cancer Research.[4] Montelione continues his research as a Professor and Constellation Endowed Chair
in the Department of Chemistry and Chemical Biology at Rensselaer Polytechnic University and as
Distinguished Professor Emeritus at Rutgers University.

Career
From 2000 to 2016, Montelione was Director of the National Institutes of Health (NIH) Northeast
Structural Genomics Consortium (NESG),[5] funded through the NIH Protein Structure Initiative.[6] The
NESG program developed new technology for protein sample production, NMR, X-ray crystallography,
and structural bioinformatics. More than 1,200 protein three-dimensional structures were determined by
the NESG team, led by Montelione, using crystallography and NMR.[7] Most of these were the first
structures determined from large protein families, providing the basis for creating three-dimensional
models of hundreds of thousands of protein structures by homology modeling and machine learning.

With G. Wagner (Michigan), Montelione carried out pioneering work on NMR pulse sequence
development, including the design and implementation of the first triple-resonance protein NMR
experiments for determining polypeptide resonance assignments,[8] as well as the ZZ-exchange and J1-
resolved E_COSY experiments.[9] At Rutgers, he followed up this work by development of the HCCNH-
TOCSY, HCCcoNH-TOCSY, and related triple-resonance NMR experiments used for determining
resonance assignments and 3D structures of proteins.

Montelione has made key contributions in computational NMR methods development, including the
development of software for automated analysis of protein resonance assignments, automated analysis of
3D structures, and for protein NMR model quality assessment. Work with Prof. R. Krug on structure-
function relationships of the influenza A non-structural protein 1 (NS1) and SARS corona virus proteases
have provided the basis for creation of attenuated virus vaccines and leads for antiviral drug development.

Currently, as an advisor to the world-wide Protein Data Bank, and co-chair of the international wwPDB
Task Force on NMR Structure Validation,[10] Montelione leads efforts to standardize methods for protein
NMR model validation. He is also a member of the Prediction Assessment Committee of the Critical
Assessment of Protein Structure Prediction (CASP).

Montelione was co-scientific founder of Structure Function Genomics, Inc.,[11] Geneformatics, Inc.,[12]
and Nexomics Biosciences, Inc.[13]

Honors and awards

Damon Runyon Cancer Research Fellowship Award[14]
Searle Scholar Award[15]
Johnson & Johnson Research Discovery Award
American Cyanamid Award in Physical and Analytical Chemistry
National Science Foundation Young Investigator Award[16]
Procter & Gamble Young Investigator Award
Camille Dreyfus Teacher-Scholar Award[17]
Rutgers University Board of Trustees Award for Scholarly Excellence
Biophysical Society Michael and Kate Bárány Award for Young Investigators[18]
Elected Fellow of the American Association for the Advancement of Science (AAAS)[19]
Inaugural Jerome and Lorraine Aresty Endowed Chair, Rutgers University[20]

References
 1. "Gaetano T Montelione, Constellation Chair in Structural Bioinformatics" (https://scholar.goo
gle.com/citations?user=mrtpF44AAAAJ&hl=en). scholar.google.com. Retrieved 2022-03-02.
2. "Gaetano T. Montelione | Science at RPI" (https://science.rpi.edu/chemistry/faculty/gaetano-t
-montelione). Gaetano T. Montelione | Science at RPI. Retrieved March 1, 2022.
3. "Department of Molecular Biology and Biochemistry" (https://mbb.rutgers.edu/). Department
of Molecular Biology and Biochemistry. Retrieved March 10, 2022.
4. "Board of Governors Appoints Gaetano Montelione First Holder of Aresty Chair in Cancer
Research" (https://www.rutgers.edu/news/board-governors-appoints-gaetano-montelione-fir
st-holder-aresty-chair-cancer-research). Rutgers University. Retrieved February 28, 2022.
5. "The Northeast Structural Genomics (NESG)" (https://www.nesg.org/). Rensselaer
Polytechnic Institute: Structural Bioinformatics Laboratory. Retrieved March 10, 2022.
6. "Protein Structure Initiative" (https://www.nigms.nih.gov/research/specificareas/PSI). Protein
Structure Initiative (program ended 7/1/2015). Retrieved March 10, 2022.
7. Michalska, K.; Joachimiak, A. (2021). "Structural genomics and the Protein Data Bank" (http
s://www.jbc.org/article/S0021-9258(21)00537-8/fulltext). The Journal of Biological
Chemistry. 296: 100747. doi:10.1016/j.jbc.2021.100747 (https://doi.org/10.1016%2Fj.jbc.20
21.100747). PMC 8166929 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166929).
PMID 33957120 (https://pubmed.ncbi.nlm.nih.gov/33957120). Retrieved March 10, 2022.
8. "PII: 0022-2364(90)90098-T - 0000522.pdf" (https://deepblue.lib.umich.edu/bitstream/handl
e/2027.42/28702/0000522.pdf;sequence=1). University of Michigan Libraries Deep Blue
Repositories. Retrieved March 1, 2022.
9. Montelione, Gaetano T.; Winkler, Marjorie E.; Rauenbuehler, Peter; Wagner, Gerhard
(1989). "Accurate measurements of long-range heteronuclear coupling constants from
homonuclear 2D NMR spectra of isotope-enriched proteins" (https://www.sciencedirect.com/
science/article/abs/pii/0022236489901832). Journal of Magnetic Resonance. 82 (1): 198–
204. Bibcode:1989JMagR..82..198M (https://ui.adsabs.harvard.edu/abs/1989JMagR..82..19
8M). doi:10.1016/0022-2364(89)90183-2 (https://doi.org/10.1016%2F0022-2364%2889%29
90183-2). hdl:2027.42/28152 (https://hdl.handle.net/2027.42%2F28152). Retrieved
March 10, 2022.
10. "wwPDB Task Force on NMR Structure Validation" (https://www.wwpdb.org/task/nmr).
wwPDB: NMR Validation. Retrieved March 10, 2022.
11. "The Next Chapter in the Book of Life Is Written in the Proteins" (https://www.nytimes.com/2
000/07/04/science/the-next-chapter-in-the-book-of-life-is-written-in-the-proteins.html). The
New York Times. July 4, 2000. pp. Section F, Page 1. Retrieved February 28, 2022.
12. "GeneFormatics schafft durch Fusion und Lizenzvertrag die erste integrierte strukturelle
Plattform für die Genomforschung | 24.01.2001" (https://www.ots.at/presseaussendung/OTS
_20010124_OTS0024/geneformatics-schafft-durch-fusion-und-lizenzvertrag-die-erste-integri
erte-strukturelle-plattform-fuer-die-genomforschung). APA-OTS. January 24, 2001.
Retrieved February 28, 2022.
13. "Nexomics Biosciences, Inc" (https://nexomics.com). Nexomics Biosciences, Inc. | Protein
Production, Structural Biology, Bioinformatics, Discovery. Retrieved March 10, 2022.
14. "All awardees.xlsx - Awardees 1980.pdf" (https://www.damonrunyon.org/sites/default/files/A
wardees%201980.pdf) (PDF). Damon Runyon Cancer Research Foundation. Retrieved
February 28, 2022.
15. "Gaetano T. Montelione - Searle Scholars Program" (https://www.searlescholars.net/people/
gaetano-t-montelione). The Searle Scholars Program. Retrieved February 28, 2022.
16. "NSF 95-81 Division of Molecular and Cellular Biosciences FY 1994 Awards" (https://www.n
sf.gov/pubs/stis1995/nsf9581/nsf9581.txt?org=DEB). National Science Foundation. April 10,
1995. Retrieved February 28, 2022.
17. "Untitled - camille-past.pdf" (https://www.dreyfus.org/wp-content/uploads/2018/07/camille-pa
st.pdf) (PDF). Retrieved February 28, 2022.
18. "Society Awards - The Biophysical Society" (https://www.biophysics.org/awards-funding/soci
ety-awards#barany_past). The Biophysical Society. Retrieved February 28, 2022.
19. "aaas_ar06_2223_fellows.pdf" (https://www.aaas.org/sites/default/files/AnnualReports/2006/
aaas_ar06_2223_fellows.pdf) (PDF). AAAS American Association for the Advancement of
Science. Retrieved February 28, 2022.
20. "Board of Governors Appoints Gaetano Montelione First Holder of Aresty Chair in Cancer
Research" (https://www.rutgers.edu/news/board-governors-appoints-gaetano-montelione-fir
st-holder-aresty-chair-cancer-research). Rutgers Today. April 15, 2010. Retrieved
February 28, 2022.

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