NANODRUG FORMULATION USING LIPOSOME CARRIER

AND VINCA ALKALOIDS WITH REFERENCE TO BREAST

AND COLON CANCER

A dissertation submitted to the University of Kerala

In partial fulfilment of the requirement for the degrec of

MASTER OF SCIENCE

IN

BIOTECHNOLOGY

By

AMINABEEVIN
81419602002

ANIVERSITy F KERAL

DEPARTMENT OF BIOTECHNOLOGY

UNIVERSITY OF KERALA

KARIAVATTOM

THIRUVANANTHAPURAM

AlGUST 2021
 NIVERS/yOF
KERALA

DEPARTMENT OF BIOTECHNOLOGY

UNIVERSITY OF KERALA
as University
Established as University of Travancore by university Actin 1937 and reconstituted
Travancore
Act of 1974
of Kerala by the Kerala Act of 1957 and presently governed by the Kerala University
University
passed by the Kerala Legislative Assembly
Kariavattom, Thiruvananthapuram
Kerala, India 695 581

Phone: +91-471-2308778
Dr. Gangaprasad A
Tele-fax: +91-471-2308778
Professor and Head
Web site: www.keralauniversity.aC.in
Email: biotechkariavattom@gmail.com

CERTIFICATE

This is to certify that, M.Sc. dissertation thesis entitled as "Nano Drug Formulation Using
Liposome Carrier And Vinca Alkaloids With Reference To Breast And Colon Cancer" an
authentic bonafide record of original independent research carried out by Ms. AMINA BEEVIN
in the Department of Biotechnology, University of Kerala, Kariavattom, Thiruvananthapuram,
under the guidance and supervision of Dr. A. Jayakumaran Nair, Emeritus Professor,
Department of Biotechnology, University of Kerala. No part of this work has been submitted
earlier for the award of any degree in this University.

Blo-te
e n to f

Examineers echno/ 7loefoa

Kerale Prof. (Dr.) Gangaprasad A.

1.
UniysPrsity ot
2.
 DEPARTMENT OF BIOTECHNOLOGY
UNIVERSITY OF KERALA

Dr. A. Jayakumaran Nair

uNIVERSSITY
OF

Professor and Head (Retd.)

KERALFormer
LA Director, IUCGGT
University of Kerala
Department of Biotechnology
University of Kerala

CERTIFICATE
This is to certify that the dissertation ertitled "Nano Drug Formulation Using Liposome
Carrier And Vinca Alkaloids With Reference To Breast And Colon Cancer" is
bonafide record of research work carried out at IU-cGGT, Department of Biotechnology
University of Kerala by Ms. AMINA BEEVI N under my guidance and supervision at
TU-CGGT, Department of Biotechnology. University of Kerala, and no part of this work
has been presented before anywhere by anyone for the award of any degree in this

university.

t of e

e,10-Techn
Dr. A. JAYAKUMARAN NAIR
iVersity ofK
 NANO DRUG FORMULATOIN USING LIPOSOME CARRIER AND
ANNONACIN WITH REFERANCE TO BREAST AND COLON
CANCER

A dissertation submitted to the University of Kerala in partial fulfilment of the requirement

for the

Degree of

MASTER OF SCIENCE

IN

BIOTECHNOLOGY

Submitted by

ANITHA KUMARI K M

(REG.NO: 81419602005)

VERSITY(OF A
KERALA
A

DEPARTMENT OF BIOTECHNOLOGY

UNIVERSITY OF KERALA

KARIAVATTOM

THIRUVANANTHAPURAM

AUGUST 2021
 DEPARTMENT OF BIOTECHNOLOGY
UNIVERSITY OF KERALA
Dr. A. Gangaprasad
Professor& Head
Department of Biotechnology
University of Kerala, Kariavattom
Thiruvananthapuram
JNIVERSI of KERAL

CERTIFICATE

This is to certify that the dissertation entitled "Nano Drug Formulation Using

Liposome Carrier And Annonacin With Reference To Breast And Colon Cancer" is
bonafide record of research work carried out at Department of Biotechnology, University of
Kerala by Ms. ANITHA KUMARI K M under the guidance and supervision of Dr. A.

Jayakumaran Nair, Emeritus Professor, Department of Biotechnology, University of Kerala

and no part of this work has been presentedbefore anywhere by anyone for the award of any

degree in this university.

oosdoal
rtment, Bio-fec
ntor Dr. A. Gangaprasad
echno
Kerala
University
e ot
 DEPARTMENTOF BIOTECHNOLOGY
UNIVERSITY OFKERALA
Dr. A. Jayakumaran Nair
Professor &Head(Retd)
Emeritus Professor
Department of Biotechnology
University of Kerala, Kariavattom
Thiruvananthapuram
HIVERSIT OF KERALA

CERTIFICATE

This is to certify that the dissertation entitled "Nano Drug Formulation Using
Liposome Carrier And Annonacin With Reference To Breast And Colon Cancer is
bonafide record of research work caried out by Ms. ANITHA KUMARI K M under my

guidance and supervision atDepartment of Biotechnology, University of Kerala and no part

of this work has been presented anywhere by anyone before the award of any degree in this

university.

nent
of
.

Dr. A. JAYÁKUMARAN NAIR

Keral
Versity o
Examiners:

1.
MTRR (A66G) Gene Polymorphism and its association with
Methotrexate Drug Responses in Rheumatoid Arthritis

Patients of Kerala Population

A dissertation submitted to the University of Kerala

In partial fulfilment of the requirement for the Degree of

MASTER OF SCIENCE

IN

BIOTECHNOLOGY

Submitted by
DHUJANA NS

(REGNO: 81419602007)

UNIVERS OF

KERALA
R S I T Y .

DEPARTMENT OF BIOTECHNOLOGYY

UNIVERSITY OF KERALA

KARIYAVATTOM

THIRUVANANTHAPURAM

AUGUST 2021
 UNIVERS OF

KERAL

DEPARTMENT OF BIOTECHNOLOGY
UNIVERSITY OF KERALA
Established as University of Travancore by Travancore university Actin 1937 and reconstituted as University
of Kerala by the Kerala University Act of 1957 and presently governed by the Kerala University Act of 1974

passed by the Kerala Legislative Assembly

Kariavattom, Thiruvananthapuram
Kerala, India 695 581

Dr. Gangaprasad A. Phone: +91-471-2308778

Professor and Head Tele-fax: +91-471-2308778
Web site: www.keralauniversity.ac.in
Email: biotechkariavattom@gmail.com

CERTIFICATE
is to certify that, M.Sc. dissertation thesis entitled as "MTRR (A66G) Gene
0phism and its association with Methotrexate Responses in Rheumatoid Arthritis
of Kerala Population" an authentic bonafide record of original independent research
carried out by Ms. DHUJANA N S in the Department of Biotechnology, University of Kerala,
atlom, Thiruvananthapuram, under the guidance and supervision of Dr. A. Jayakumaran
neritus Professor, Department of Biotechnology, University of Kerala. No part of this
submitted carlier for the award of any degree in this University.

310-18gCh
X iners
.
hno/ oqlosflo

Prof. (Dr.) Gangaprasad A.

2.
 DEPARTMENT OF BIOTECHNOLOGY
UNIVERSITY OF KERALA
NIVERSI7y OF
Dr. A. Jayakumaran Nair
Professor and Head (Retd.)
KERALA
F o r m e r Director, IUCGGT
University of Kerala
Department of Biotechnology
University of Kerala
CERTIFICATE
This is to certify that the dissertation entitled "MTRR (A66G) Gene Polymorphism and
Responses in Rheumatoid Arthritis Patients of
its association with Methotrexate
work carried out at IU-CGGT,
Kerala Population" is bonafide record of research
DHUJANA N S under my
Department of Biotechnology, University of Kerala by Ms.
University of
Eclance and supervision at IU-CGGT, Department of Biotechnology,
before anywhere by anyone for the
Kerala, and nopart of this work has been presented
award of any degree in this university.
of Bio
Aechno
KERA,
JAYAKUMARAN NAIR
fversitY
ofKeta
Dr. A.
 IDENTIFICATION OF MICRO RNAS REGULATING

DIFFERENTIALLY EXPRESSED GENES IN CISPLATIN RESISTANTT

OVARIAN CANCER CELLS

A dissertat ion submitted to the University of Kerala

In partial fulfillment of the requirement for the degree of

MASTER OF SCIENCE

IN

BIOTECHNOLOGY

By
KAVYA PRAKASH

REG NO: 81419602010

UNIVERSI7 OF

KERALA
(

DEPARTMENT OF BIOTECHNOLOGY

UNIVERSITY OF KERALA

KARIAVATTOMM

THIRUVANANTHAPURAM

AUGUST 2021
 DEPARTMENT OF BIOTECHNOLOGY
UNIVERSITY OF KERALA
Established as University of Travancore by Travancore
university Actin 1937 and reconstituted as University
of Kerala
by the Kerala University Act of 1957 and prosentily governed by the Kerala
University Act of 1974
passed by the Kerala Legislative Assembly
Kariavattom, Thiruvananthapuram
Kerala, India 695 581
Dr. Gangaprasad A. Phone: +91-471-2308778
Professor and Head Tele-fax: +91-471-2308778
Web site: www.keralauniversity.ac.in
Email: biotechkariavattom@gmail.com
CERTIFICATE
This is to certify that, M.Sc. dissertation thesis entitled as "IDENTIFICATION OF MICRO
RNAS REGULATING DIFFERENTIALLY EXPRESSED GENES IN CISPLATIN
RESISTANT OVARIAN CANCER CELLS" an authentic bonafide record of
original
independent research carried out by Ms. KAVYA PRAKASH in the Department of Biotechnology,
Unive of Kerala, Kariavattom, Thiruvananthapuram, under the guidance and supervision of
Dr. A naran Nair, Emeritus Professor, Department of Biotechnology, University of
ar of this work has been submitted earlier for the award of any degree in this
8i0-fe
echnofo
n e no
t f
AERALA
Exn Crs
of
Keral
o40s
1. nivniversity Prof. (Dr.) Gangaprasad A.
2.
 DEPARTMENT OF BIOTECHNOLOGY
UNIVERSITY OF KERALA
JAIVERSI7 OF
Dr. A. Jayakumaran Nair
Professor and Head (Retd.)
KERAL Former Director, IUCGGT
University of Kerala
Department of Biotechnology
University of Kerala
CERTIFICATE
This is to certify that the dissertation entited "DENTIFICATION OF MICRO RNAS
REGULATING DIFFERENTIALLY EXPRESSED GENES CISPLATIN IN
RESISTANT OVARIAN CANCER CELLS" is bonafide record of research work carried out
at IlCGGT,
Department of Biotechnology, University of Kerala by Ms. KAVYA PRAKASH
under ny guidance and supervision at IU-CGGT, Department of Biotechnology, University of
Kerala. and no part of this work has been presented before anywhere by anyone for the award
e in this university.
v n e r t e s
Dr. A. JAYAKUMARAN NAIR
1ATION OF METASTASIS ASSOCIATED LUNG ADENOCARCINOMA
EVAL

DA NSCRIPT 1 (MALAT-1) IncRNA EXPRESSION CHANGES DURING

DIFFERENT STAGES OF WHITE ADIPOGENESIS

A dissertation submitted to the University of Kerala

In partial fulfilment of the requirement for the degree of

MASTER OF SCIENCE

IN

BIOTECHNOLOGY

By
ROHAN PETER MATHEW

REG. N0: 81419602011

JNIVERS7 TY OF KERAL

DEPARTMENT OF BIOTECHNOLOGY

UNIVERSITY OF KERALA

KARIAVATTOM

THIRUVANANTHAPURAM
AUGUST 2021
 NIVERS/ S t T Y

KERAL4

DEPARTMENT OF BIOTECHNOLOGY
UNIVERSITY OF KERALA
Established es University of Travancore by Travancore university Actin 1937 and reconstituted as University
of Kerala by the Kerala University Act of 1957 and presently governed by the Kerala University Act of 1974
passed by the Kerala Legislative Assembly

Kariavattom, Thiruvananthapuram
Kerala, India - 695 581

Dr. Gangaprasad A. Phone:+91-471-2308778

Professor and Head Tele-fax: +91-471-2308778
Web site: www.keralauniversity.ac.in
Email: biotechkariavattom@gmail.com

CERTIFICATE
This is to certify that, M.Sc. dissertatiori thesis entitled as " EVALUATION OF METASTASIS

ASSOCIATED LUNG ADENOCARCINOMA TRANSCRIPT 1 (MALAT-1) IncRNA

EXPRESSION CHANGES DURING DIFFERENT STAGES OF WHITE
ADIPOGENESIS" an authentic bonafide record of original
independent research carried out by
Mr. ROHAN PETER MATHEW in the
Department of Biotechnology, University of Kerala,
Kariavattom, Thiruvananthapuram, under the guidance and supervision of Dr. A. Jayakumaran
Nair, Emeritus Professor, Department of Biotechnology, University of Kerala. No
part of this
work has been submitted earlier for the award of
any degree in this University.

of Bio.
Examiners e n to f

*44, Aechno o4
Da
1.
Prof. (Dr.) Gangaprasad A.
Kera

2. UnyeS sity o
 DEPARTMENT OF BIOTECHNOLOGY
UNIVERSITY OF KERALA

NIVERSIT Y OF A
Dr. A. Jayakumaran
Professor and Head (Retd.)
Nair
EKERALA Former Director, IUcGGT
University of Kerala
Department of Biotechnology
University of Kerala

CERTIFICATE
This is to certify that the dissertation entitled "EVALUATION OF METASTASIS
ASSOCIATED LUNG ADENOCARCINOMA TRANSCRIPT 1 (MALAT-1) IncRNA
EXPRESSION CHANGES DURIYG DIFFERENT STAGES OF WHITE

ADIPOGENESIS" is bonafide record of research work carried out at IU-CGGT

Department of Biotechnology, University of Kerala by Mr. ROHAN PETER MATHEW
under my guidance and supervision at IU-CGGT, Department of Biotechnology, University
of Kerala, and no part of this work has been presented before anywhere by anyone for the
ward of any degree in this university.

jo-techo
mentof

eeeeate

Dr. A. JAYAKUMARAN NAIR

Uniyersity
of
Keral
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