Name of product: Januvia (Sitagliptin)
Indication: an adjunct to diet and exercise to improve glycemic control n adults with T2DM
Ingredient(s): Active Ingredient: Sitagliptin
Contraindications: History of a serious hypersensitivity reaction to sitagliptin, such as
anaphylaxis or angioedema.
Interactions:
Drug-drug: Sulfonylureas and insulin: Increased risk of hypoglycemia when used in
combination with these agents.; Drug-food: There are no significant drug-food interactions,
and Januvia can be taken with or without food.
Dose/frequency/route: Dose: The recommended dose of Januvia is 100 mg once daily. Route:
Oral (by mouth). Frequency: Once daily, typically taken at the same time each day, with or
without food.
Pharmacology: By inhibiting the DPP-4 enzyme, Januvia increases the levels of incretin
hormones like GLP-1 and GIP, which in turn:
Stimulate insulin secretion in response to meals.
Decrease glucagon secretion, reducing hepatic glucose production.
Side effects: Common: Upper respiratory infection; Headache; Nasopharyngitis
Goals of therapy/how do you know they are reached
A1c<7% for most adults, fasting blood glucose: 80-130 mg/dL, postprandial blood glucose:
<180 mg/dL
Action to take if overdose, any role for the Poison Control Center?
Call 911, if patient is conscious and able to swallow, provide fruit juice, glucose tablets, or
administer glucagon
Follow up: Frequent blood glucose monitoring is essential, especially before and after meals.
check a1c every 3 months, Kidney function tests should be performed periodically, especially
in patients with preexisting renal impairment, as dose adjustments may be needed for
reduced renal function..
