7 Weight Management
7 Weight Management
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GLOBAL ISSUE
National, regional, and global trends in adult overweight and obesity prevalences Gretchen A Stevens et al.for the Global
Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index)
• Increasing prevalence of
obesity is a serious health
problem.
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LOCAL SCENARIO FR
Do we have role?
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consequences
Intake Output
UNIVERSITY OF SANTO TOMAS
DEPARTMENT OF NUTRITION AND DIETETICS
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PATHOPHYSIOLOGY FR
GENETICS
BMR
LIPOPROTEIN LIPASE
LEPTIN
GHRELIN
FAT CELL DEVELOPMENT
SET POINT THEORY
FETAL ORIGIN OF ADULT DISEASE
ENVIRONMENT
PHYSICAL ACTIVITY
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Fat Cell Development
The amount of fat reflect both the number and
size of fat cells
Increase most rapidly during late adulthood
and early puberty
Grow whenever energy balance is positive
When cells enlarge they stimulate cell proliferation so that the numbers
increase again
A decrease in body weight only changes fat cell size (becoming smaller),
whereas an increase in body weight causes elevation of both fat cell size and
number in adults
Arner P. Fat Tissue Growth and Development in Humans. Nestle Nutr Inst Workshop Ser. 2018;89:37-45. doi: 10.1159/000486491.
Epub 2018 Jul 10. PMID: 29991030.
UNIVERSITY OF SANTO TOMAS
DEPARTMENT OF NUTRITION AND DIETETICS
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Fat Cell Metabolism
Lipoprotein lipase (LPL) promotes fat storage in both adipose and
muscle cells
- In women, more LPL is found in breast, hips and thighs
- In men, LPL is in the abdomen
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Set Point Theory
Proposes that the body tends to maintain a certain weight
by means of its own internal controls
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Leptin
• A protein produced by fat cells under direction of the ob gene that
decreases appetite and increases energy expenditure
• Fat cells in obese rats injected with leptin not only lose fat, but they reduce in
number, which explains why weight gains are delayed when the mice are
fed again
• Obese people have high leptin, and weight gain increases leptin
concentrations
• When energy intake is low, leptin levels decline
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Ghrelin
• A protein produced by the stomach cells that enhances appetite
and decreases energy expenditure
• Blood levels of ghrelin rise before and fall rapidly after a meal
• Lean people have high ghrelin levels and obese people have low
ghrelin levels
• Ghrelin levels decline when the body is in positive energy balance
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Uncoupling Proteins
• White adipose tissue: stores fat for other cells to use for energy
(coupling)
• Brown adipose tissue: releases stored energy as heat (uncoupling)
• Production of heat is important in newborns and adults who live in
extremely cold climates
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Measures of obesity:
WHO CLASSIFICATION
BMI= 25 ABOVE
Under weight <18.5
Normal weight 18.5-24.9
Overweight 25.0-29.9
Obesity Class 1 30.0-34.9
Obesity Class 2 35.0-39.9
Obesity Class 3 >40
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Body Mass Index (BMI)
• Below a BMI of 17, signs of illness, reduced
work capacity, and poor reproductive
function become apparent
• BMI reflect height and weight, but not
body composition: a person who is
overweight may not be overfat
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2. WAIST CIRCUMFERENCE
3. WAIST TO HIP
RATIO
MEN ≥ 0.95
FEMALE ≥ 0.8
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http://apps.who.int/
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Neck circumference showed a strong correlation with abdominal obesity, as well as with the
component risk factors of metabolic syndrome, and therefore with risk of cardiovascular disease.
Above the NC cut off levels, its predictive value for abdominal obesity is high; however, it has a poor
ability to detect patients with abdominal obesity in the general population and therefore, cannot be
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used as a screening test.
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Fat Distribution
• Intra-abdominal fat that is stored around
the organs of the abdomen, independently
of total body fat, is associated with
increased risk of heart disease, stroke,
diabetes, hypertension, and some types of
cancer
• Abdominal fat is common in post-
menopausal women, and even more
common in men
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HIGHER
HEALTH
RISK
UNIVERSITY OF SANTO TOMAS
DEPARTMENT OF NUTRITION AND DIETETICS
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Fat Distribution
• Fat around the hips and thighs, common in women, seems relatively
harmless
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TYPES OF FAT
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CONSEQUENCES TO HEALTH FR
CONSEQUENCES TO HEALTH FR
Role of lipotoxicity and inflammation on obesity. White adipose tissue (WAT) releases pre–fatty acids and
adipokines, which are lipotoxic and inflammatory and result in diverse effects, outlined in the left-hand
columns. Their correlation to the metabolic syndrome is shown on the right-hand column, whereas all the
effects culminate in atherosclerosis on the bottom of the figure.
*Perturbed glucose and lipid metabolism. DM-2=diabetes mellitus-2; FFA=free fatty acids; IL=interleukin; IRS=insulin receptor substrate; NF-KB=nuclear factor kappa beta; NS=nervous system;
PAI-1=plasminogen activator inhibitor-1; SMC=smooth muscle cell; TG=triglyceride; TNF=tumor necrosis factor
UNIVERSITY OF SANTO TOMAS Redinger R. N. (2007). The pathophysiology of obesity and its clinical manifestations. Gastroenterology & hepatology, 3(11), 856–863.
DEPARTMENT OF NUTRITION AND DIETETICS
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CONSEQUENCES TO HEALTH FR
Obese chronic low-level inflammation, cause
DNA damage cancer.
CONSEQUENCES TO HEALTH FR
Arthritis: degeneration of joint: weight bearing and inflammation
Obstructive sleep apnea: accumulation of extra adipose tissue in the upper respiratory
tract hypoxia, ventilation and even hypercapnia
Gallstone: During fasting, there is enhanced mobilization of cholesterol from fat depots,
which pass through the liver into the biliary ducts
Depression
Redinger R. N. (2007). The pathophysiology of obesity and its clinical manifestations. Gastroenterology & hepatology, 3(11), 856–863.
UNIVERSITY OF SANTO TOMAS
DEPARTMENT OF NUTRITION AND DIETETICS
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MANAGEMENT OF OBESITY
Goals: STRATEGIES:
- Attaining the best weight
possible in the context of Lifestyle modifications
over-all health
Diet
- An initial goal of 5-10% Physical activity
weight loss over 6 months Behavior Modification
– Limit associated morbidity Drugs
and mortality Surgery
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Reasonable
Weight Loss
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Assessment
• Anthropometric measures;
• biochemical data, medical tests and procedures;
• nutrition-focused physical findings; and
• client history
• energy intake and nutrient content of the diet.
• motivation, readiness and self-efficacy for weight management
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Dietary Intervention
• individualized diet
• maintain nutrient adequacy
• reduce caloric intake:
• 1,200 kcal to 1,500 kcal/day for women
• and 1,500 to 1,800 kcal/day for men;
• energy deficit of approximately 500 kcal/ day or 750 kcal/day;
• restrict certain food types in order to create an energy deficit by
reduced food intake.
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Dietary Intervention
Small, food-based changes:
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Dietary Intervention
Small, food-based changes:
Fruit and vegetable consumption
-reduce dietary energy density, enhance satiation, and assist with
decreasing overall energy intake,
- higher in energy density.
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Dietary Intervention
Small, food-based changes:
SSB Consumption
-replacing caloric beverages with water or diet beverages
resulted in weight losses of 2% to 2.5% during a 6-month period.
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Dietary Intervention
Small, food-based changes:
Fast Food Consumption
-generally high in energy density and
commonly purchased in large portion
sizes,
UNIVERSITY OF SANTO TOMAS Image from google search (The Sun and New York Times)
DEPARTMENT OF NUTRITION AND DIETETICS
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Dietary Intervention
Portion Control:
: using packages containing a
defined amount of energy (eg,
complete meals, individual
food; portion-controlled utensils;
food is delivered in specific
serving sizes; or communication
strategies
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Dietary Intervention
• Energy density
• DASH eating plan
• Mediterranean Diet
• Eating frequency
• Time of Eating
• Breakfast consumption
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Be Physically Active.
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current recommendation:
minimum of 30 minutes of moderate-intensity activity
on most days of the week (150 min/wk).
weight-loss maintenance:
higher levels of MVPA (>250 min/week)
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DAY-TO-DAY
ACTIVITIES
HABITUALLY AND
REGULARLY
FOR METABOLIC
EFFICIENCY
30-45
minutes a day
10-15
minutes at a time 3-5
days a week Images from google search (cdc and heart.org)
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BEHAVIOR AND ATTITUDE.
Make a plan to address interfering issues
Assess readiness to change Invite the patient to let you know when he or she is ready
Build the patient’s confidence to make an effort toward
Solve problem/s together
weight loss
with the patient
Agree on goals For the patient who expresses readiness to change, simple
Teach Self monitoring and steps include:
Stimulus control Praise patients who have had recent or past weight loss
even if their BMI is still in the overweight or obese range
Ask the patient about past and current weight loss
Empower the client to change strategies and what is working and not working for them
behavior (adapt healthier lifestyle) Ask the patient how you may help in their weight loss
Teach them to make informed efforts
choices Acknowledge their values in linking weight to health
Provide motivation issues
UNIVERSITY OF SANTO TOMAS The American Journal of Medicine (2016) 129, 115.e1-115.e7
DEPARTMENT OF NUTRITION AND DIETETICS
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Behavior-Change Intervention:
Theoretical framework that proposes that with the use of learning
principles, such as classical and operant conditioning, healthy
behaviors can be learned.
Cognitive-Behavioral Therapy:
uses a directive, action-oriented approach and provides skills to help
individuals learn to develop functional thoughts and behaviors.
- proposes that thoughts, feelings, and behaviors interact to impact
health outcomes.
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Motivational Interviewing:
focuses on the style of interaction between a practitioner and client.
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PHARMACOLOGIC. FR
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SURGERY: FR
Vertical
Banded
Gastroplasty
Roux-en-Y
Gastric Bypass
Gastric
Banding
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When to consider gastric bypass:
Obesity Class 3
(WHO / NIH = BMI 40; AP > 35)
Obesity Class 2 with co-morbid conditions
(WHO / NIH = BMI 35; AP 30)
Consider if other weight loss attempts have failed
Lifelong medical monitoring
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Eating
Disorders
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Definition
Psychiatric conditions characterized by severe disturbance in eating
behavior, resulting in a significant physiologic impairment and even death.
serious and often fatal illnesses that are associated with severe disturbances
in people’s eating behaviors and related thoughts and emotions and not a
lifestyle choice
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Anorexia Nervosa
refusal or inability to maintain minimally normal body
weight, leading to a body weight that is <85% of what is
expected for age and height.
Restricting type
Binge-eating/purging type
see themselves as overweight, even
when they are dangerously underweight
typically weigh themselves repeatedly,
severely restrict the amount of food they
eat,
often exercise excessively,
and/or may force themselves to vomit
or use laxatives to lose weight.
UNIVERSITY OF SANTO TOMAS Understanding Normal and Clinical Nutrition
DEPARTMENT OF NUTRITION AND DIETETICS https://www.nimh.nih.gov/
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Bulimia Nervosa
characterized by repeated episodes of binge eating followed by
abnormal compensatory weight-loss behaviors such as self-
induced vomiting, fasting, excessive exercise and misuse of
laxatives and diuretics.
Purging type
Nonpurging type
recurrent and frequent episodes of eating unusually large amounts of food and feeling a
lack of control over these episodes followed by behavior that compensates for the
overeating such as forced vomiting, excessive use of laxatives or diuretics, fasting,
excessive exercise, or a combination of these behaviors.
People with bulimia nervosa may be slightly underweight, normal weight, or over
overweight.
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HEALTH IMPLICATIONS: FR
ANOREXIA NERVOSA
•BRADYCARDIA
•HYPOTENSTION
•ORTHOSTATIC HYPOTENSION
•HYPOTHERMIA
•AMENORRHEA
•OSTOPENIA/OSTEOPOROSIS
BULIMIA NERVOSA
•ESOPHAGITIS
•GERD
•CARDIAC ARRHYTMIAS
UNIVERSITY OF SANTO TOMAS
•DEHYDRATION
DEPARTMENT OF NUTRITION AND DIETETICS
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NUTRITION THERAPY:
ANOREXIA NERVOSA
GOAL: to restore patient’s weight (90%)
- cessation of weight loss behaviors
- improvement in emotional and psychological health
Management:
•Initial kcal= 30-40 kcal/kgbw
slowly progressing
•Vitamin and mineral supplements
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NUTRITION THERAPY:
BULIMIA NERVOSA
GOAL: to reduce chaotic cycle of binging and purging
- normalize eating habits
Management:
•Three meals with 1-3 snacks/day
•Counseling
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For your
future patients.
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