TIME RELEASE NIACIN

CLINICAL APPLICATIONS
• Promotes Healthy Blood Lipid Levels
• Supports Healthy High-Density Lipoprotein (HDL) Levels
• Maintains Healthy Low-Density Lipoprotein (LDL) Levels and Lipid Particle Size
• Maintains Healthy Triglyceride Levels
• Enhances Endothelial Function by Increasing Nitric Oxide Synthase

CARDIOVASCULAR HEALTH
What is Niacin? Overview
Niacin, also known as vitamin B3, is a micronutrient with a Niacin is required by the body to promote the health and
40-year history of efficacy in supporting healthy lipid levels, function of the digestive system, liver, skin and nerves.3-4 It also
especially high-density lipoprotein cholesterol (HDL-C) plays a role in converting food to energy. Niacin is found in
levels. However, one side effect often makes supplementing dairy products, eggs, grains, fish, lean meats, nuts and legumes.
niacin a less than pleasurable experience, limiting adherence. It is a water-soluble vitamin, meaning that excess is excreted
Some patients experience flushing when supplementing through the urine and continuous dietary intake is necessary
niacin. However, a properly- manufactured, sustained- to support optimal health.
release niacin circumvents this side effect. By using a Niacin is most known for its broad cardiovascular benefits,
proprietary, natural wax-matrix coating technology, Time but is also an important nutrient for bone health, blood sugar
Release Niacin is released slowly over a six- to eight-hour
balance and cerebrovascular function.5-9 Populations that
period to reduce flushing. This time period is considered consume adequate levels of niacin have been shown to have
the ideal window for releasing equal amounts of niacin into better outcomes for long-term health.10
circulation as nicotinuric acid, the beneficial metabolite
responsible for niacin’s lipid balancing benefits.1-2 In a Niacin Depletion†
double-blind placebo-controlled study, this specific form of Symptoms of mild deficiency of niacin may include indigestion,
Time Release Niacin had only a 5-7 % flush rate, making it fatigue, canker sores and depression. Niacin deficiency, if left
well-tolerated and highly effective for supporting balanced unattended, can negatively affect brain function leading to
cholesterol levels. apathy, fatigue, disorientation and memory loss.
Plasma Niacin Concentration

Cardiovascular Health and Cholesterol Balance†

Immediate-Release Niacin Niacin has been used since the 1950s to maintain healthy
++++ Flushing response
balance of cholesterol levels. Since 1978, researchers have
labeled niacin a “front-line” nutrient for cardiovascular support. [11]
Time-Release Niacin The National Cholesterol Education Program (NCEP) panel
+ Flushing response
designated niacin a “first-line therapy” for support of specific
parameters related to balancing cholesterol levels in 1988,
further emphasizing the micronutrient’s safety and importance
in cardiovascular health.12 Other studies have shown niacin to
0 1 2 3 4 5 6 7 8 enhance long-term cardiovascular health.7-10
Representative plasma pharmacokinetic profiles
of immediate-release vs time-release niacin preparations.
Adapted from Chapman et al. (2010)

† These statements have not been evaluated by the Food and Drug Administra-
tion. This product is not intended to diagnose, treat, cure, or prevent any disease.
 When taken at doses greater than the Recommended Daily References
Amount (RDA), niacin: 1. Keenan JM, Fontaine PL et al. Niacin revisited. A
• Promotes healthy high-density lipoprotein (HDL) levels randomized, controlled trial of wax-matrix sustained-
already within the normal range by 20-35%. No other nutrient release niacin in hypercholesterolemia. Arch Intern Med. 1991
or compound has been shown to be as effective in supporting Jul;151(7):1424-32.information.
healthy HDL levels. 2. Keenan JM,Bae CY et al.Treatment
• Maintains healthy lipid particle size. Small low-density of hypercholesterolemia: comparison of younger versus older
lipoprotein (small LDL) particles are an important yet patients using wax-matrix sustained-release niacin. J Am Geriatr
underappreciated marker of cardiovascular function. Niacin is the Soc. 1992; 40(1):12-8.
most effective agent known for supporting a normal cholesterol
3. Bissett DL, Oblong JE, Berge CA, et al. Niacinamide:
pattern.
A B vitamin that improves aging facial skin appearance. Dermatol
• Supports healthy triglyceride levels. Niacin is especially
Surg. 2005;31:860-865; discussion 865.
effective when taken with fish oil (at doses of 1,500-3,000 mg of
EPA/DHA daily). 4. Benavente CA, Jacobson MK, Jacobson EL. NAD in
• Supports normal very low-density lipoprotein (VLDL) skin: therapeutic approaches for niacin. Currr Pharm Des.
particles. 2009;15(1):29-38.

LY • Supports healthy lipoprotein(a), or Lp(a) levels. No other

treatment approaches the power of niacin to promote healthy
5. Elam M, Hunninghake DB, Davis KB, et al. Effects of
niacin on lipid and lipoprotein levels and glycemic control in
Lp(a) levels, which is among the most important markers of heart patients with diabetes and peripheral arterial disease: the ADMIT
health. study: a randomized trial. Arterial Disease Multiple Intervention
T FACTS• Promotes low-density lipoprotein (LDL) balance. Trial. JAMA. 2000;284:1263-1270.
Niacin supports lipid balance by blocking the release of fatty
14pt SFB
acids from fat cells. Fewer BODY
fatty acids 4.5ptto the
are passed through
6. Canner PL, Furberg CD, Terrin ML, McGovern ME.
Benefits of niacin by glycemic status in patients with healed
liver, resulting in fewer VLDL particles. Less VLDL leads to less myocardial infarction (from the Coronary Drug Project). Am J
4.5pt
small LDL and higher HDL. To the benefit of the 4.5pt
FOOTNOTE cardiovascular Cardiol. 2005; 95(2):254-7.
system, niacin also improves endothelial function and nitric
OTHER 7. Guyton JR. Niacin in cardiovascular prevention:
oxide synthase activity which protects blood vessels and
INGREDIENT
promotes healthy circulation.
6pt mechanisms, efficacy, and safety. Curr Opin Lipidol. 2007
Aug;18(4):415-20.
Directions 8. McKenney J. New perspectives on the use of
1 tablet three times per day with a meal or as recommended by niacin in the treatment of lipid disorders. Arch Intern Med. 2004
your health care professional. Apr 12;164(7):697-705.

9. Morgan JM,Carey CM,Lincoff A,Capuzzi DM. The

Does Not Contain effects of niacin on lipoprotein subclass distribution. Prev Cardiol.
Gluten, corn, yeast, artificial colors or flavors.
2004; 7(4):182-7.

Cautions 10. AIM-HIGH Investigators. The role of niacin in

If you are pregnant or nursing, consult your physician before raising high-density lipoprotein cholesterol to reduce
taking this product. This product is designed to release niacin cardiovascular events in patients with atherosclerotic
over a six- to eight- hour period to minimize flushing (Avoiding cardiovascular disease and optimally treated low-density
hot beverages is recommended). A small percentage of people lipoprotein cholesterol Rationale and study design. The
may still experience harmless flushing while taking this product. Atherothrombosis Intervention in Metabolic syndrome with low
HDL/high triglycerides: Impact on Global Health outcomes (AIM-

Supplement Facts
V2
0000000000000

HIGH). Am Heart J. 2011 Mar;161(3):471-477.e2.

11. Kannel WB. Recent findings from the Framingham

Serving Size 1 Tablet study—I. Med Times. 1978 Apr;106(4):23-27
Servings Per Container 90
12. Hulley SB. The US National Cholesterol Education
Amount Per % Daily Program. Adult treatment guidelines. Drugs. 1988;36 Suppl
1 tablet contains Serving Value
3:100-04.
Niacin 500 mg 3,125%
(as Nicotinic Acid)‡
LT-PDN-199-A
Other146090
ID# Ingredients:90
Vegetable
Tablets waxes (Rice Bran and or Carnauba),
Stearic Acid, Magnesium Stearate, and Silica.

† These statements have not been evaluated by the Food and Drug Administra-
tion. This product is not intended to diagnose, treat, cure, or prevent any disease.
Ortho Molecular Products, Inc. 1991 Duncan Place, Woodstock, IL 60098
LEARN MORE ABOUT US AT OrthoMolecularProducts.com
‡