1,3-DIPHENYL GUANIDINE MATERIAL SAFETY DATA SHEET

CAS No 102-06-7 SDS/MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : 1,3-Diphenyl guanidine

CAS-No. : 102-06-7
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Industrial & for professional use only.
1.3 Details of the supplier of the safety data sheet
Company : Central Drug House (P) Ltd
7/28 Vardaan House
Ansari Road Daryaganj
New Delhi -110002
INDIA
Telephone : +91 11 49404040
Email : care@cdhfinechemical.com

1.4 Emergency telephone number

Emergency Phone # : +91 11 49404040 (9:00am - 6:00 pm) [Office hours]

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 3), H301
Skin irritation (Category 2), H315
Eye irritation (Category 2), H319
Reproductive toxicity (Category 2), H361f
Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
Chronic aquatic toxicity (Category 2), H411
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008

Pictogram

Signal word Danger

Hazard statement(s)
H301 Toxic if swallowed.
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 H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
H361f Suspected of damaging fertility.
H411 Toxic to aquatic life with long lasting effects.
Precautionary statement(s)
P261 Avoid breathing dust.
P273 Avoid release to the environment.
P281 Use personal protective equipment as required.
P301 + P310 IF SW ALLOW ED: Immediately call a POISON CENTER/doctor.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazard none
Statements
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances
Formula : C13H13N3
Molecular weight : 211.26 g/mol
CAS-No. : 102-06-7
EC-No. : 203-002-1
Index-No. : 612-149-00-4

Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration
1,3-Diphenylguanidine
CAS-No. 102-06-7 Acute Tox. 3; Skin Irrit. 2; Eye <= 100 %
EC-No. 203-002-1 Irrit. 2; Repr. 2; STOT SE 3;
Index-No. 612-149-00-4 Aquatic Chronic 2; H301,
H315, H319, H361f, H335,
H411
For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11

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4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx)
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Storage class (TRGS 510): Combustible solids, toxic
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters
8.2 Exposure controls
Appropriate engineering controls
Avoid contact with skin, eyes and clothing. W ash hands before breaks and immediately after handling
the product.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).

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 Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use (EN 143) respirator
cartridges as a backup to engineering controls. If th full-face supplied air respirator. Use respirators
and components tested and approved under appropriate government standards such as NIOSH
(US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Appearance Form: crystalline
b) Odour No data available
c) Odour Threshold No data available
d) pH No data available
e) Melting point/freezing Melting point/range: 146 - 148 °C - lit.
point
f) Initial boiling point and > 250 °C at ca.1,010 hPa - OECD Test Guideline 103
boiling range
g) Flash point No data available
h) Evaporation rate No data available
i) Flammability (solid, gas) No data available
j) Upper/lower flammability No data available
or explosive limits
k) Vapour pressure No data available
l) Vapour density No data available
m) Relative density No data available
n) Water solubility 0.325 g/l at 20 °C - OECD
Test Guideline 105 - soluble
o) Partition coefficient: n-
Pow: 2.42 at 21.1 °C
octanol/water
p) Auto-ignition
No data available
temperature
q) Decomposition
temperature No data available

r) Viscosity No data available

s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
Surface tension ca.58.8 mN/m at 23 °C
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SECTION 10: Stability and reactivity
10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
No data available
10.5 Incompatible materials
Strong oxidizing agents
10.6 Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx)
Other decomposition products - No data available
In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male - 111 mg/kg(1,3-Diphenylguanidine)
(OECD Test Guideline 401)
LD50 Oral - Rat - female - 107 mg/kg(1,3-Diphenylguanidine)
(OECD Test Guideline 401)
LD50 Dermal - Rabbit - male and female - > 2,000 mg/kg(1,3-Diphenylguanidine)
Skin corrosion/irritation
No data available(1,3-Diphenylguanidine)
Serious eye damage/eye irritation
Eyes - Rabbit(1,3-Diphenylguanidine)
Result: Irritating to eyes. - 24 h
(Draize Test)
Respiratory or skin sensitisation
Maximisation Test - Guinea pig(1,3-Diphenylguanidine)
Result: Does not cause skin sensitisation.
(OECD Test Guideline 406)
Germ cell mutagenicity

in vitro assay(1,3-Diphenylguanidine)
lymphocyte
Result: negative
Result: Not mutagenic in Ames Test
Mutagenicity (in vivo mammalian bone-marrow cytogenetic test, chromosomal analysis)(1,3-
Diphenylguanidine)
Rat - male and female
Result: negative

Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.

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 Reproductive toxicity
Suspected human reproductive toxicant(1,3-Diphenylguanidine)
Specific target organ toxicity - single exposure
No data available(1,3-Diphenylguanidine)
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available(1,3-Diphenylguanidine)

Additional Information
Repeated dose toxicity - Mouse - male and female - No observed adverse effect level - 75 mg/kg - Lowest
observed adverse effect level - 114 mg/kg(1,3-Diphenylguanidine)
RTECS: MF0875000

To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.(1,3-Diphenylguanidine)

SECTION 12: Ecological information

12.1 Toxicity
Toxicity to fish static test LC50 - Pimephales promelas (fathead minnow) - 4.2 mg/l - 96 h(1,3-
Diphenylguanidine)
Toxicity to daphnia and static test EC50 - Daphnia magna (W ater flea) - 17 mg/l - 48 h(1,3-
other aquatic Diphenylguanidine)
invertebrates
Toxicity to algae static test EC50 - Desmodesmus subspicatus (Scenedesmus subspicatus) - 7.5
mg/l - 72 h(1,3-Diphenylguanidine)
Toxicity to bacteria Respiration inhibition EC50 - Sludge Treatment - 147 mg/l - 3 h(1,3-
Diphenylguanidine)
(OECD Test Guideline 209)
12.2 Persistence and degradability
Biodegradability Biotic/Aerobic - Exposure time 28 d(1,3-Diphenylguanidine)
Result: 55 - 71 % - Not readily biodegradable.
(OECD Test Guideline 301B)

12.3 Bioaccumulative potential

Bioaccumulation Cyprinus carpio (Carp) - 42 d
- 0.1 mg/l(1,3-Diphenylguanidine)

Bioconcentration factor (BCF): <

2 (OECD Test Guideline 305C)

12.4 Mobility in soil

No data available(1,3-Diphenylguanidine)
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative
and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

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12.6 Other adverse effects
Toxic to aquatic life with long lasting effects.

SECTION 13: Disposal considerations

13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the
material with a combustible solvent and burn in a chem scrubber.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number
ADR/RID: 2811 IMDG: 2811 IATA: 2811
14.2 UN proper shipping name
ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (1,3-Diphenylguanidine)
IMDG: TOXIC SOLID, ORGANIC, N.O.S. (1,3-Diphenylguanidine)
IATA: TOXIC SOLID, ORGANIC, N.O.S. (1,3-Diphenylguanidine)
14.3 Transport hazard class(es)
ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
14.4 Packaging group
ADR/RID: III IMDG: III IATA: III
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
H301 Toxic if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
H361f Suspected of damaging fertility.
H411 Toxic to aquatic life with long lasting effects.
Further information

The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent
any guarantee of the properties of the product. Central Drug House (P) Ltd and its Affiliates shall not
be held liable for any damage resulting from handling or from contact with the above product. See
www.cdhfinechemical.com for additional terms and conditions of sale.

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