ra
MCQs
3. Man and certain other species cannot synthesise vitamin C
1. Limeys' was the nickname given to which of the following because they lack one of the following enzymes
nationality for carrying crates of lemons rich in vitamin C b) glucuronidase
during voyages in the medieval times a) phosphoglucomutase
a) French b) British c) L-gulonolactone oxidase d) xylitol dehydrogenase
c) Dutch d) Russian observed in
4. Low serum levels of vitamin C are
a) heavy smokers
2. Ascorbic acid resembles the following compound in its b) chronic alcoholics
structure
a) monosaccharides b) fatty acids c) women on oral contraceptives
c) amino acids d) nucleotides d) all the above
5. Vitamin C is essential for the post-translational 15, Wernicke-Korsakoff syndrome is seen in
modifications of the following amino acids in collagen a) smokers b) drug addicts
a) proline and cysteine b) lysine and arginine c) chronic alcoholics d) all the
c) proline and lysine d) histidine and methionine above
16. Flavin coenzymes (FMN and FAD) are
6. The vitamin required for wound healing is
a) vitamin A b) vitamin D
following type of reactions
a) hydroxylation
c) oxidation-reduction
b) decarboxylation
d) transamination
invoved in the
c) vitamin C d) none of the above
17. Which of the following
7. Which of the following is a naturally occurring antioxidant formation of FMN and FAD? hormones is associated
a) vitamin C b) vitamin E a) insulin b) cortisol with the
c) B-carotene d) all the above c) epinephrine d) thyroxine
8. Al the following statements are true with regard to 18. All the following enzymes are
vitamin Cexcept succinate dehydrogenase
dependent on
b) alkaline FAD except
a) it is essential for hydroxylation of tryptophan to form
serotonin
c) pyruvate dehydrogenase
19. Laboratory measurement of the
phosphatase
d) xanthine oxidase
b) it is required for the formation of carnitine
c) it is used in transamination reactions
following enzyme R8Cis
used to assess riboflavin deficiency in
d) it promotes non-heme iron absorption by reducing the a) glutathione reductase b) superoxide dismutase
ferric iron to ferrous iron c) pyruvate dehydrogenase d) xanthine oxidase
20. Niacin can be synthesised from the
9. All the following statements about scurvy are true except
a) capillary fragility causes internal bleeding resulting in a) tyrosine following amino aid
b) threonine
petechiae, ecchymoses, hemarthrosis and so on c) tryptophan d) histidine
b) oxalate renal stones are observed 21. NAD" and NADP* are the
c) associated with impaired wound healing and anemia coenzymes of the
d) swollen and tender gums with loosened teeth are observed
vitamin
a) thiamine b) riboflavin
fol owing
10. All the following enzymes need TPP as a coenzyme except c) niacin d) pyridoxine
a) pyruvate dehydrogenase 22. All the following
b) acyl CoA dehydrogenase are correct except
statements with regard to NAD SUnthk.
c) a-ketoglutarate dehydrogenase a) ATP donates AMP moiety
d) transketolase
b) ribose phosphate is provided by PRPP
11. Dietary requirement of thiamine increases with higher c) qlutamine provides the amide group
intake of
d)
quinolinate donates the pyrophosphate moiety.
a) carbohydrates b) fats
c) proteins 23. Allthe following
d) cholesterol statements are false except
a) NADPH is oxidised by
12. Which of the following is a poor
dietary source of vitamin b) NADH is needed for
respiratory chain to generate ATP
thiamine?
c) NADPH is generated in
biosynthetic reactions
a) parboiled and polished rice pentose phosphate pathway
b) hand-pounded, d) NADH participates in
c) whole wheat flour
unpolished rice transamination reactions
24. Althe following enzymes are dependent on NAD extej
d) ultra-polished, refined rice
a) pyruvate
13. Measurement of the dehydrogenase complex
b) enoyl reductase
to assess the following is used as a diagnostic test
deficiency status of thiamine c) glyceraldehyde-3-phosphate dethydrogenase
a) serum pyruvate d) B-hydroxyacyl CoA
RBC transaldolasedehydrogenase
activity levels dehydrogenase
c) RBC 25. Which of the following enzymes is dependent on NADP"?
d) transketolase activity a) glucose-6-phosphate dehydrogenase
methylmalonic acid content in urine
14. All the
following are
a) wet beriberi is true about beriberi except
glyceraldehyde-3-phosphate dehydrogenase
c) malate dehydrogenase
as edema and characterised by cardiovascular signs such d) B-hydroxy butyrate dehydrogenase
b) peripheral palpitation 26.
c) dry neuropathy is common in wet beriberi
beriberi is
All the following generate
NADPH except
featured by HMP shunt
progressive muscle wasting neurological signs such
d) death may
as b) malic enzyme
occur due to cardiac c) alcohol dehydrogenase
bernberi. failure in infantile d) cytosolic isocitrate
dehydrogenase
Which of the following amino acids inhibit the synthesis
27. and NADP from tryptophan?
40. which of the anti-tuberculosis drug causes vitamin B6
of NAD' b) leucine deficiency?
a) lysine a) rifampicin b) ethambutol
c) isoleucine d) cysteine 175
c) streptomycin d) isoniazid
necklace' is seen in the following disease 41. Carpal tunnel syndrome may occur if there is deficiency of
9 'Casal's
a) beriberi b) scurvy a) B2 b) B,
c) pernicious anemia d) pellagra c) cyanocobalamine d) niacin
29. All
the following conditions may induce pellagra except 42. One of the following vitamins is considered to be an 'anti
syndrome egg-white-injury factor
a) malignant carcinoid
b) nephrotic syndrome a) thiamine b) folate
c) isoniazid therapy c) pyridoxine d) biotin
d) Hartnup disease 43. Biotin takes part in one of the following types of reactions
a) transamination b) decarboxylation
Hyperlipidemiasare treated by administering the following
30. vitamin in megadoses c) carboxylation d) deamination
a) B,2 b) folate 44. All the following enzymes are dependent on biotin except
c) thiamine d) niacin a) acetyl CoA carboxylase
b) pyruvate carboxylase
31, Pellagra occurs in people whose staple diet is c) propionyl CoA carboxylase
a) wheat b) maize
d) none of the above
d) carbamoyl phosphate synthase
c) rice
45. The following molecule plays the role of an allosteric
32. PLP is the coenzyme of the following vitamin activator CO, fixation reactions dependent on biotin
a) B b) B, a) acetyl CoA b) propionyl CoA
) B, d) B2 c) succinylCoA d) bicarbonate ion
33. Pyridoxal phosphate (PLP) is required for the following 46. Coenzyme Ais a derivative of the following vitamin
reaction
a) thiamine b) cobalamine
a) transamination b) decarboxylation c) pantothenate d) pyridoxine
) transsulphuration d) all of the above
34. Schiff base is formed in the following reaction mechanism
47. Allthe following enzymes require coenzyme Aexcept
a) transamination b) decarboxylation
a) pyruvate dehydrogenase
c) transsulphuration b) lactate dehydrogenase
d) none of the above
) a-ketoglutarate dehydrogenase
35. The following biogenic amine is synthesised by d) thiokinase
decarboxylation dependent on PLP
a) histamine b) serotonin 48. Pantothenic acid is a component of one of the following
c) GABA d) all the above multienzyme complexes
a) fatty acid synthase
36. Allthe following statements about B, are correct except
b) pyruvate dehydrogenase
a) the synthesis of NAD and NADP from tryptophan is
c) a-ketoglutarate dehydrogenase
dependent on PLP d) glycogen phosphorylase
b) homocysteine levels in blood are elevated in B, deficiency
c) the requlatory enzyme of glycogen synthesis is PLP 49. All the following compounds are synthesised in one carbon
dependent metabolism with the help of tetrahydrofolate except
a) the regulatory enzyme of heme synthesis is PLP dependent a) purine nucleotides b) TMP
c) UMP d) serine, glycine and choline
. Daily requirement of vitamin B. is dependent on the Vitam
intake of
a) carbohydrates
50. Which one of the following vitamins is essential for the
b) lipids liberation of free THF from N5-Methyl THF
c) proteins Wate
d) all the above a) 8, b) B,
38.
Neurological symptoms
to the following impairedin B, deficiency can be attributed
function of PLP
c) B, d) B12
a) transamination 51. All the following statements regarding folate are true
c) transsulfuration b) decarboxylation except
d) deamination a) macrocytic anemia occurs in folate deficiency
9.
Elevated homocysteine levels which are associated with b) pregnant women are vulnerable for folate deficiency 10
increased risk of cardiovascular disease occurs in the c) folate plays an important role in carbohydrate metabolism CrYR
deficiency of the following
vitamin d) coenzyme of folate acts as a carrier of one carbon groups
b) B,
d) B,
52. Folate deficiency causes
a) macrocytic anemia
59. The synthesis of methionine from
b) neural tube
defects
c) hyperhomocysteinemia
by the enzyme homocysteine
the following coenzyme
homocys teine
methyltransferase
d) all the above
a) cyanocobalamin b) methylcobalamin
in the laboratory to assess
the c) deoxyadenosyl cobalamin d)
176
53. Histidine load test is used
deficiency status of the following vitamin
b) pyridoxine
60. Accumulation of the
hydroxycobalamin
following compound is
a) B12
c) folate d) thiamine
for the neurological manifestations
BË2 deficiency observedreisnponitsanidmein
54. Which of the following does not act as a folate antagonist? a) succinyl CoA b) propionyl CoA
a) sulphonamides b) ciprofloxacin c) acetyl CoA d) methylmalonyl CoA
c) methotrexate d) trimethoprim
61. Deficiency of which of the following two vitamins resut
55. Vitamin B,2 is synthesised by in similar type of anemia
a) only plants b) only animals a) B, and B, b) B, and niacin
c) only microorganisms d) all the above c) folate and B d) Band B2
56. Which of the following compounds is a coenzyme of 62. All the following disorders occur in vitamin Bp
vitamin B12? deficiene
except
a) cyanocobalamin b) methylcobalamin a) megaloblastic anemia
c) hydroxycobalamin d) nitrocobalamin b) pernicious anemia
57. Which of the following statements is correct about vitamin c) subacute combined degeneration
B2? d) iron deficiency anemia
a) extrinsic factor synthesised by intestinal
mucosal cells is 63. Absence of the following molecule leads to
essential for the absorption of vitamin B,2 pernicious
b) haptocorrin is aprotein synthesised by liver, it anemia
vitamin B,2 in plasma transports a) transcobalamin b) haptocorrin
c) vitamin B2 is stored by the liver c) intrinsic factor d) none of the above
in the form of
cyanocobalamin
d) intrinsic factor produced by 64. All the following statements are true about
gastric vitamin Bs
essential for the absorption of vitamin B,2parietal cells is except
a) methylcobalamin and deoxyadenosyl cobalamin are the
58. Vitamin B, is stored by the liver in the
following form coenzyme forms of vitamin B,
a) deoxyadenosyl cobalamin b) b) neurological damage in B2 deficiency can be corrected y)
c) cyanocobalamin methylcobalamin
d) nitrocobalamin administering folatein therapeutic dosage
c) methylmalonyl COAis accumulated in B,,
d) folic acid is trapped as N5-Methyl THF in deficiency
B,2 deficiency
Answers
1. b 2. a 3. c 4. d 5. c
8. c 6. c 7.d
9. b 10. b 11. a 12. d 13. c
E
15. c 16. c 17, d 14. b
18. b 19. a 20. c Scan QR code to acces
22. d 23. c 24. b 21. c
25. a
29. b 30. d 31. b
26. c 27. b 28. d Riddles and Problems
32. c 33. d 34. a
36. c 37.c 38. b 35. d
43. c 39. a 40. d 41. b
44. d 45. a 42. d
50. d 46, c 47. b
51. c 48. a 49, c
52. d 53. c
57, d 58. a 54. b 55. c
59. b 60. d 56. b
64. b 61. c 62. d 63. c
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