COMBINED LIST OF DRUGS THAT PROLONG QT AND/OR CAUSE TORSADES DE POINTES (TDP)

CredibleMeds® has reviewed available evidence for the drugs on the following list and
place them in one of three designated categories: Known Risk of TdP (KR), Possible Risk
of TdP (PR) or have a Conditional Risk of TdP (CR). The full description of these
categories can be found on the CredibleMeds.org website.

Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name
Abarelix (PR) Plenaxis Zithromax and Clarithromycin (KR) Biaxin and others
Azithromycin (KR)
others
Abiraterone (CR) Zytiga and others Clofazimine (PR) Lamprene
Bedaquiline (PR) Sirturo
Aclarubicin (KR) Aclacin and others Clomipramine (CR) Anafranil
Bendamustine (PR) Treanda and others
Alfuzosin (PR) Uroxatral Clotiapine (PR) Entumine
Bendroflumethiazide
Alimemazine Clozapine (PR) Clozaril and others
Nedeltran and others (Bendrofluazide) Aprinox and others
(Trimeprazine) (PR)
(CR) Cobimetinib (PR) Cotellic
Amantadine (CR) Symmetrel and others
Benperidol (PR) Anquil and others Cocaine (KR) Cocaine
Amiodarone (KR) Cordarone and others
Bepridil (KR) Vascor Crizotinib (PR) Xalkori
Amisulpride (CR) Solian and others
Betrixaban (PR) Bevyxxa Cyamemazine
Tercian
Elavil (Discontinued (Cyamepromazine) (PR)
Amitriptyline (CR) Bortezomib (PR) Velcade and others
6/13) and others
Dabrafenib (PR) Tafinlar
Bosutinib (PR) Bosulif
Amphotericin B (CR) Fungilin and others
Dasatinib (PR) Sprycel
Buprenorphine (PR) Butrans and others
Amsacrine (Acridinyl
Amsidine Firmagon and
anisidide) (CR) Cabozantinib (PR) Cometriq Degarelix (PR)
others
Anagrelide (KR) Agrylin and others Capecitabine (PR) Xeloda
Delamanid (PR) Deltyba
Apalutamide (PR) Erleada Ceritinib (PR) Zykadia
Pertofrane and
Desipramine (PR)
Apomorphine (PR) Apokyn and others Aquachloral and others
Chloral hydrate (CR)
others
Aripiprazole (PR) Abilify and others Deutetrabenazine (PR) Austedo
Chloroquine (KR) Aralen
Arsenic trioxide (KR) Trisenox Precedex and
Dexmedetomidine (PR)
Thorazine and others
Artemether/Lumefantrine Chlorpromazine (KR)
Coartem others
(PR) Dextromethorphan/Quinidine
Nuedexta
Chlorprothixene (KR) Truxal (PR)
Artenimol/piperaquine (PR) Eurartesim
Cilostazol (KR) Pletal Benadryl and
Asenapine (PR) Saphris and others Diphenhydramine (CR)
others
Cimetidine (CR) Tagamet
Astemizole (KR) Hismanal
Disopyramide (KR) Norpace
Ciprofloxacin (KR) Cipro and others
Atazanavir (CR) Reyataz and others
Dofetilide (KR) Tikosyn
Cisapride (KR) Propulsid
Atomoxetine (PR) Strattera
Dolasetron (PR) Anzemet
Citalopram (KR) Celexa and others
Domperidone (KR) Motilium and others

If list is printed, check website at www.crediblemeds.org • Please see Disclaimer below • List continued over
Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name
Donepezil (KR) Aricept Gemifloxacin (PR) Factive Lenvatinib (PR) Lenvima
Doxepin (CR) Sinequan and others Gilteritinib (PR) Xospata Leuprolide (Leuprorelin) (PR) Lupron and others
Dronedarone (KR) Multaq Glasdegib (PR) Daurismo Levofloxacin (KR) Levaquin and others
Droperidol (KR) Inapsine and others Granisetron (PR) Kytril and others Levomepromazine
Nosinan and others
(Methotrimeprazine) (KR)
Efavirenz (PR) Sustiva Grepafloxacin (KR) Raxar
Levomethadone (levamethadone)
Eliglustat (PR) Cerdelga Halofantrine (KR) Halfan
(PR)
Encorafenib (PR) Braftovi Haloperidol (KR) Haldol and others
Levomethadyl acetate (KR) Orlaam
Entrectinib (PR) Rozlytrek Hydrochlorothiazide (CR) Apo-Hydro and others
Levosulpiride (KR) Lesuride and others
Eperisone (CR) Myonal and others Hydrocodone - ER (PR) Hysinglaâ„¢ ER and others
Lithium (PR) Eskalith and others
Epirubicin (PR) Ellence and others Hydroquinidine
Serecor Lofexidine (PR) Lucemyra
(Dihydroquinidine) (KR)
Eribulin mesylate (PR) Halaven
Loperamide (CR) Imodium
Hydroxychloroquine (KR) Plaquenil and others
Erythromycin (KR) E.E.S. and others
Lopinavir/Ritonavir (PR) Kaletra and others
Hydroxyzine (CR) Atarax and others
Escitalopram (KR) Cipralex and others
Maprotiline (PR) Ludiomil
Ibogaine (KR)
Esomeprazole (CR) Nexium and others
Melperone (PR) Bunil and others
Ibutilide (KR) Corvert
Ezogabine (Retigabine)
Potiga and others Memantine (PR) Namenda XR
(PR) Iloperidone (PR) Fanapt and others
Mesoridazine (KR) Serentil
Famotidine (CR) Pepcid and others Imipramine (Melipramine)
Tofranil
(PR) Methadone (KR) Dolophine and others
Felbamate (PR) Felbatol
Indapamide (CR) Lozol and others Metoclopramide (CR) Reglan and others
Fingolimod (PR) Gilenya
Inotuzumab ozogamicin (PR) Besponsa Metolazone (CR) Zytanix and others
Flecainide (KR) Tambocor and others
Isradipine (PR) Dynacirc Metronidazole (CR) Flagyl
Fluconazole (KR) Diflucan and others
Itraconazole (CR) Sporanox and others Mianserin (PR) Tolvon
Fluorouracil (5-FU) (PR) Adrucil and others
Ivabradine (CR) Procoralan and others Midostaurin (PR) Rydapt
Fluoxetine (CR) Prozac and others
Ivosidenib (PR) Tibsovo Mifepristone (PR) Korlym and others
Flupentixol (PR) Depixol and others
Ketanserin (PR) Sufrexal Mirabegron (PR) Myrbetriq
Fluvoxamine (CR) Faverin and others
Ketoconazole (CR) Nizoral and others Mirtazapine (PR) Remeron
Furosemide (frusemide)
Lasix and others
(CR) Lacidipine (PR) Lacipil and others Moexipril/Hydrochlorothiazide (PR) Uniretic and others
Galantamine (CR) Reminyl and others Lansoprazole (CR) Prevacid Moxifloxacin (KR) Avelox and others
Garenoxacin (CR) Geninax Lapatinib (PR) Tykerb and others Necitumumab (PR) Portrazza
Gatifloxacin (KR) Tequin Lefamulin (PR) Xenleta Nelfinavir (CR) Viracept

If list is printed, check website at www.crediblemeds.org • Please see Disclaimer below • List continued over
 Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name
Nicardipine (PR) Cardene Posaconazole (CR) Noxafil and others Tacrolimus (PR) Prograf and others
Nifekalant (KR) Shinbit Pretomanid (PR) Tamoxifen (PR) Nolvadex and others
Nilotinib (PR) Tasigna Primaquine phosphate (PR) Telaprevir (CR) Incivo and others
Norfloxacin (PR) Noroxin and others Probucol (KR) Lorelco Telavancin (PR) Vibativ
Nortriptyline (PR) Pamelor and others Procainamide (KR) Pronestyl and others Telithromycin (PR) Ketek
Nusinersen (PR) Spinraza Promethazine (PR) Phenergan Terfenadine (KR) Seldane
Ofloxacin (PR) Floxin Propafenone (CR) Rythmol SR and others Terlipressin (KR) Teripress and others
Olanzapine (CR) Zyprexa and others Propofol (KR) Diprivan and others Terodiline (KR) Micturin and others
Omeprazole (CR) Losec and others Prothipendyl (PR) Dominal and others Tetrabenazine (PR) Nitoman and others
Ondansetron (KR) Zofran and others Quetiapine (CR) Seroquel Thioridazine (KR) Mellaril and others
Osimertinib (PR) Tagrisso Quinidine (KR) Quinaglute and others Tiapride (PR) Tiapridal and others
Oxaliplatin (KR) Eloxatin Quinine sulfate (CR) Qualaquin Tipiracil/Trifluridine (PR) Lonsurf
Oxytocin (PR) Pitocin and others Ranolazine (CR) Ranexa and others Tizanidine (PR) Zanaflex and others
Paliperidone (PR) Invega and others Ribociclib (PR) Kisqali Tolterodine (PR) Detrol and others
Palonosetron (PR) Aloxi Rilpivirine (PR) Edurant and others Toremifene (PR) Fareston
Panobinostat (PR) Farydak Risperidone (CR) Risperdal Torsemide (Torasemide)
Demadex and others
(CR)
Pantoprazole (CR) Protonix Romidepsin (PR) Istodax
Tramadol (PR) Crispin and others
Papaverine HCl (Intra- Roxithromycin (KR) Rulide and others
coronary) (KR) Trazodone (CR) Desyrel and others
Saquinavir (PR) Invirase(combo)
Paroxetine (CR) Paxil and others Trimipramine (PR) Surmontil and others
Sertindole (PR) Serdolect and others
Pasireotide (PR) Signifor Tropisetron (PR) Navoban and others
Sertraline (CR) Zoloft and others
Pazopanib (PR) Votrient Valbenazine (PR) Ingrezza
Sevoflurane (KR) Ultane and others
Pentamidine (KR) Pentam Vandetanib (KR) Caprelsa
Siponimod (PR) Mayzent
Perflutren lipid microspheres Vardenafil (PR) Levitra
Definity and others Solifenacin (CR) Vesicare
(PR)
Vemurafenib (PR) Zelboraf
Sorafenib (PR) Nexavar
Perphenazine (PR) Trilafon and others
Venlafaxine (PR) Effexor and others
Sotalol (KR) Betapace and others
Pilsicainide (PR) Sunrythm
Voriconazole (CR) VFend
Sparfloxacin (KR) Zagam
Pimavanserin (PR) Nuplazid
Vorinostat (PR) Zolinza
Sulpiride (KR) Dogmatil and others
Pimozide (KR) Orap
Ziprasidone (CR) Geodon and others
Sultopride (KR) Barnetil and others
Pipamperone (PR) Dipiperon and others
Zotepine (PR) Losizopilon and others
Sunitinib (PR) Sutent
Piperacillin/Tazobactam (CR) Tazosyn and others
Zuclopenthixol
Cisordinol and others
Pitolisant (Tiprolisant) (PR) Wakix (Zuclopentixol) (PR)

Note: Medicines on this list are reviewed on an ongoing basis to assure that the available evidence supports their continued placement on this list. Because, the list changes regularly, we
recommend always checking the website at crediblemeds.org for the most up-to-date information. Most drugs have multiple brand names and it is not practical to list them on this form. The
CredibleMeds.org website provides a partial list of the more common brands.

Disclaimer and Waiver: The information presented here is intended solely for the purpose of providing general information about health-related matters. It is not intended for any other
purpose, including but not limited to medical advice and/or treatment, nor is it intended to substitute for the users’ relationships with their own health care providers. To that extent, by use of
this list and the information it contains, the user affirms the understanding of the purpose and releases AZCERT, Inc. from any claims arising out of his/her use of this list. The Terms of Use
Agreement for this list and the CredibleMeds website is available at https://www.crediblemeds.org/terms. The absence of drugs from these lists should not be considered an indication that
they are free of risk of QT prolongation or torsades de pointes. Few medicines have been tested for this risk in patients, especially those with congenital long QT syndrome. This list and the
CredibleMeds® website are intended for personal and professional use only and are protected by U.S. Copyright (title 17, U.S. Code). Unauthorized commercial use is prohibited.

Generated: January 5, 2020. List last revised: December 26, 2019