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Abrams’
Clinical Drug Therapy
Rationales for Nursing Practice
11th Edition
Abrams’
Clinical Drug Therapy
Rationales for Nursing Practice
11th Edition
GERALYN FRANDSEN, EdD, RN
Assistant Director of Nursing
Professor of Nursing
Catherine McAuley School of Nursing
Maryville University
St. Louis, Missouri
SANDRA SMITH PENNINGTON, PhD, RN
Executive Vice President of Institutional Effectiveness and Strategic
Initiatives
Rocky Mountain University of Health Professions
Provo, Utah
Professor Emeritus
Department of Nursing
Berea College
Berea, Kentucky
Executive Editor: Kelley Squazzo
Supervising Development Editor: Heather Rybacki
Editorial Coordinator: Jennifer DiRicco
Editorial Assistant: Leo Gray
Marketing Manager: Katie Schlesinger
Production Project Manager: Linda Van Pelt
Design Coordinator: Steve Druding
Art Director: Jennifer Clements
Manufacturing Coordinator: Karin Duffield
Prepress Vendor: SPi Global
Eleventh Edition
Copyright © 2018 Wolters Kluwer
Copyright © 2014, 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins. Copyright ©
2007, 2004, 2001 by Lippincott Williams & Wilkins. Copyright © 1998 by Lippincott-Raven
Publishers. Copyright © 1995, 1991, 1987, 1983 by J. B. Lippincott Company. All rights
reserved. This book is protected by copyright. No part of this book may be reproduced or
transmitted in any form or by any means, including as photocopies or scanned-in or other
electronic copies, or utilized by any information storage and retrieval system without written
permission from the copyright owner, except for brief quotations embodied in critical articles and
reviews. Materials appearing in this book prepared by individuals as part of their official duties as
U.S. government employees are not covered by the above-mentioned copyright. To request
permission, please contact Lippincott Williams & Wilkins at Two Commerce Square, 2001
Market Street, Philadelphia, PA 19103, via e-mail at permissions@lww.com, or via our web site
at lww.com (products and services).
987654321
Printed in China
Library of Congress Cataloging-in-Publication Data
Names: Frandsen, Geralyn, editor. | Pennington, Sandra Smith, editor.
Title: Abrams’ clinical drug therapy : rationales for nursing pracice / [edited by] Geralyn
Frandsen, Sandra Smith Pennington.Other titles: Clinical drug therapy
Description: 11th edition. | Philadelphia : Wolters Kluwer Health, [2018] | Includes
bibliographical references and index.
Identifiers: LCCN 2017034933 | ISBN 9781496347961
Subjects: | MESH: Pharmaceutical Preparations | Drug Therapy | Pharmacological Phenomena |
Nurses’ Instruction
Classification: LCC RM262 | NLM QV 55 | DDC 615.1/9—dc23 LC record available at
https://lccn.loc.gov/2017034933
This work is provided “as is,” and the publisher disclaims any and all warranties, express or
implied, including any warranties as to accuracy, comprehensiveness, or currency of the content
of this work.
This work is no substitute for individual patient assessment based upon healthcare professionals’
examination of each patient and consideration of, among other things, age, weight, gender,
current or prior medical conditions, medication history, laboratory data and other factors unique
to the patient. The publisher does not provide medical advice or guidance and this work is merely
a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use
of this work including all medical judgments and for any resulting diagnosis and treatments.
Given continuous, rapid advances in medical science and health information, independent
professional verification of medical diagnoses, indications, appropriate pharmaceutical selections
and dosages, and treatment options should be made and healthcare professionals should consult a
variety of sources. When prescribing medication, healthcare professionals are advised to consult
the product information sheet (the manufacturer’s package insert) accompanying each drug to
verify, among other things, conditions of use, warnings and side effects and identify any changes
in dosage schedule or contraindications, particularly if the medication to be administered is new,
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LWW.com
I would like to
dedicate this book to my
husband and fellow
contributor, Gary. Without
his love, support, and
guidance, this book would
never have been
completed. I would also
like to dedicate this book
to our children, Claire and
Joe, and our son-in-law,
John. This edition could
not have been completed
without the help and
collaboration of my
coauthor, Dr. Sandy
Pennington. To you, my
friend, I tip my hat.
Geralyn Frandsen
I dedicate this
work to my children
Jennifer and Brad, whose
constant belief in the
power of family surrounds
me with deep gratitude. I
also dedicate this book to
my granddaughter
Liliana, whose smile,
laugh, and love make
every day a “happy day.”
It is my joy to share my
life with you all.
Sandy Pennington
Contributors
Lisa Albers, MSN, RN
Clinical Assistant Professor of Nursing
BSN Coordinator
Catherine McAuley School of Nursing
Maryville University
RN Staff Nurse
Cardinal Glennon Children’s Hospital
St. Louis, Missouri
Chapter 4: Pharmacology and the Care of Infants and Pediatric
Patients
Jennifer Brunworth, MSN, RN
Clinical Assistant Professor of Nursing
Catherine McAuley School of Nursing
Maryville University
St. Louis, Missouri
Chapter 26: Drug Therapy for Hypertension
Gary Frandsen, JD, MSN, RN
Assistant Professor of Nursing
University of Missouri
St. Louis, Missouri
Chapter 22: Drug Therapy for Tuberculosis and Mycobacterium
avium Complex Disease
Chapter 35: Nutritional Support Products, Vitamins, and Mineral
Supplements
Chapter 44: Drug Therapy to Regulate Calcium and Bone
Metabolism
Susan Golden, MSN, RN
Nursing Program Director
Nursing Faculty
Eastern New Mexico University–Roswell
Roswell, New Mexico
Chapter 49: Drug Therapy With Opioids
Jennifer Binggeli Miles, PharmD, MBA, BCPS
Director of Remote Order Entry Operations
Largo, Florida
Chapter 19: Drug Therapy With Aminoglycosides and
Fluoroquinolones
Chapter 20: Drug Therapy With Tetracyclines, Sulfonamides, and
Urinary Antiseptics
Chapter 31: Drug Therapy for Nasal Congestion and Cough
Chapter 50: Drug Therapy With Local Anesthetics
Chapter 51: Drug Therapy With General Anesthetics
Chapter 58: Drug Therapy for Substance Abuse Disorders
Vicki Moran, PhD, RN, CNE
Assistant Professor
School of Nursing
Saint Louis University
St. Louis, Missouri
41: Drug Therapy for Diabetes Mellitus
42: Drug Therapy for Hyperthyroidism and Hypothyroidism
Jacqueline R. Saleeby, PhD, RN, PMHCS
Associate Professor
Catherine McAuley School of Nursing
Maryville University
St. Louis, Missouri
Chapter 56: Drug Therapy for Psychotic Disorders
Sharon Souter, PhD
Professor
College of Nursing
University of Mary Hardin Baylor
Belton, Texas
Chapter 37: Drug Therapy for Peptic Ulcer Disease and
Hyperacidity
Chapter 52: Drug Therapy for Migraines and Other Headaches
Chapter 54: Drug Therapy for Anxiety and Insomnia
Chapter 57: Drug Therapy for Attention Deficit Hyperactivity
Disorder and Narcolepsy
Elizabeth Stuesse, MSN, RNC-OB, RNC-MNN,
C-EFM, CLC
Clinical Assistant Professor
Catherine McAuley School of Nursing
Maryville University
St. Louis, Missouri
Chapter 6: Pharmacology and the Care of Pregnant or Lactating
Woman
Dana Todd, PhD, APRN
Professor
Department of Nursing
Murray State University
Murray, Kentucky
Chapter 7: Pharmacology and Women’s Health
Gladdi Tomlinson, MSN, RN
Professor of Nursing
Harrisburg Area Community College
Harrisburg, Pennsylvania
Chapter 47: Drug Therapy for Myasthenia Gravis, Alzheimer’s
Disease, and Urinary Retention
Chapter 48: Drug Therapy for Parkinson’s Disease, Urinary
Spasticity, and Disorders Requiring Anticholinergic Drug
Therapy
Jeannette Zelhart-Smith, RN
Maternity Course Coordinator
University of Saint Francis
Crown Point, Indiana
Chapter 36: Drug Therapy for Weight Management
Chapter 43: Drug Therapy for Pituitary and Hypothalamic
Dysfunction
Nina Zimmermann, MSN, APRN, ANP-BC, AE-
C
Assistant Director of Nursing
Director of the MSN Nurse Practitioner Program
Assistant Professor of Nursing
Catherine McAuley School of Nursing
College of Health Professions
Maryville University
St. Louis, Missouri
Chapter 33: Drug Therapy for Asthma and Bronchoconstriction
Reviewers
Marilyn Adair, MSN, BSN
Nursing Professor
Department of Nursing
South Puget Sound Community College
Olympia, Washington
Barbara Blackwell, EdD
Director
School of Nursing
Holy Name Medical Center School of Nursing
Teaneck, New Jersey
Billie E. Blake, EdD, MSN, BSN, RN, CNE
Professor
Associate Dean Nursing
Director BSN
Department of Nursing
St. Johns River State College
Orange Park, Florida
Judith Bradford, DNS, MSN
Associate Professor
Department of Nursing
Southeastern Louisiana University
Hammond, Louisiana
Adina Carrillo, RN, MSN, CNP, CNS
Professor of Nursing
Department of Nursing
College of the Canyons
Valencia, California
Sandy Carroll, EdD, MSN, RN
Professor
Department of Nursing
College of the Canyons
Valencia, California
Brigitte Casteel, MSN
Associate Professor
Department of Nursing
Virginia Highlands Community College—Virginia Appalachian
Tricollege Nursing Program
Abingdon, Virginia
Darlene Clark, MS, RN
Senior Lecturer in Nursing
Department of Nursing
The Pennsylvania State University
University Park, Pennsylvania
JoAnn Crownover, DNP
Associate Professor
Department of Pre-Licensure
Regis University
Denver, Colorado
Kathleen M. Reilly Dolin, DNP, RN
Professor of Nursing
Department of Nursing
Northampton Community College
Bethlehem, Pennsylvania
Mary Fabick, MSN, MEd, BSN, RN, CEN
Associate Professor of Nursing
Department of Nursing
Milligan College
Milligan College, Tennessee
Susan Golden, MSN, RN
Nursing Program Director, Nursing Faculty
Department of Nursing
Eastern New Mexico University–Roswell
Roswell, New Mexico
Rhonda Gonzalez, MSN, RN
Assistant Professor of Nursing
Department of Nursing
The University of West Alabama
Livingston, Alabama
Amy Graham, MSN, FNP-BC
Assistant Professor
Department of Nursing
James Madison University
Harrisonburg, Virginia
Teresa Gwin, EdD, MSN, NP
Director of Entry Level Masters program
Department of Nursing
Samuel Merritt University
Oakland, California
Sue Hafer, MSN, NP, ANP, FNP, RN
Instructor
Department of Pharmacology
Delta College
University Center, Michigan
NP Coordinator
Heart Failure Clinic
Bay Heart and Vascular
Bay City, Michigan
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