PREMIUM

YOUR DNA
RESULTS
Logan Phillips
Report Date: 30/01/2025
1 of 84 Personal Information

Personal
Information
Customer: Logan Phillips
Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Table of Contents 2 of 84

Table of
Contents
01 Personal Information 31 Gender Traits

02 Table of Contents 33 Behavioural Traits

03 Welcome 35 Personality Traits

Getting Started with

04 Circle 37 Success Traits

05 Genetics 101 39 Music & Dance

09 Diet 41 Pollution

12 Nutrition 43 Common Health Risks

15 Sports & Fitness 45 Disease Risk

Dementia & Brain

19 Wellbeing 52 Health

21 Stress & Sleep 54 Drug Response

23 Ancestry 62 Cancer Risk

25 Skin 67 Family Planning

28 Physical Traits
3 of 84 Welcome

Welcome
Dear Logan,

Welcome to your personalised Circle DNA test report. It’s our absolute pleasure to introduce you to you!

Your life is a story spelled out with your DNA. The most interesting facts that uniquely belong to you are
wrapped up in the strands of your genes. So, if you could rewrite your story – what would it say?

Circle Next Generation Sequencing (NGS) is the ultimate way to care for your future self by giving you a
wealth of information that allows you to alter what might have been your genetic destiny.

Our team of scientists have carefully analysed your saliva sample at our internationally-accredited
laboratory to bring you a living analysis of your DNA. In your report, you will discover insights into the
incredible story of your genome, your health, traits, and needs. Armed with this information, you will have
the power to live a longer, healthier and happier life.

By choosing Circle Next Generation Sequencing (NGS), you have joined countless individuals who have had
life-changing experiences due to the priceless data provided by genetic testing.

Read on to kickstart your journey, and to empower yourself with valuable and actionable health and
wellness insights so that you can make better choices, for you.

In health & happiness,

The Circle Team
 Getting Started with Circle 4 of 84

Getting Started
with Circle
To help you get the most out of this report, here’s a quick ‘Genetics 101’. Once you’ve got an
understanding of the basics, you’ll be all set to make the best use of your results and help apply
them to make the lifestyle changes that are right for you.

IMPORTANT TO KNOW

Circle reports tell you about genetic variations associated with certain traits

1. and health conditions. They do not diagnose for any conditions or determine
medical action.

Having a certain risk does not mean you will definitely develop a trait or

2. condition. Similarly, you could still develop a trait or condition even if you
don't have a mutation detected. It is possible to have other genetic
mutations not included in these reports.

Genetics isn’t a crystal ball - it cannot predict what will or won’t be. Factors
like lifestyle and environment can also affect whether a person develops a

3. health condition or trait. Our reports cannot tell you about your overall risk
for these conditions, and they cannot determine if you will or will not develop
a condition.

These reports do not replace visits to a healthcare professional. Your results

4. serve as a reference point, and should not be interpreted as medical advice.

Consult with a healthcare professional for help interpreting and using
genetic results.
5 of 84 Genetics 101

Genetics 101
Genes load the gun, but
lifestyle pulls the trigger.
To understand exactly what this means, it’s important to
know the basics of genetics.

What is DNA?
DNA - also known as deoxyribonucleic acid - is an extremely long chain of molecules that contains
the genetic blueprint of life on Earth. The DNA acts like a computer program - where the cell is the
hardware and the DNA is the code. This code contains all the instructions that a living organism needs
in order to grow, reproduce and function.

DNA is shaped like a ladder that’s been twisted to form what’s known as a double helix. The steps of
the ladder are made of four nucleotides also known as bases: Adenine (A), Thymine (T), Cytosine (C),
and Guanine (G). A always pairs with T, and G always pairs with C. Although there are only four bases,
the As, Cs, Ts and Gs combine in thousands of combinations to make up our entire DNA - which is a
total of 3 billion base pairs in length!

If someone were to unwind all the DNA molecules within a human body, the total length would reach
from the Earth to Pluto and back. A complete base genome would take up three gigabytes of storage
space. The entire human genome would take 50 years to type if someone types at a speed of 60
words-per-minute, eight hours a day!

T
G

Chromosomes

Cell

C
A

Gene

Nucleus
 How it Works 6 of 84

How it Works
Chromosomes carry genetic information in a molecule called DNA. Genes are segments of DNA
that influence what we look like on the outside and how we work on the inside. They contain the
information our body needs to make chemicals called proteins, which form our bodily structure and
play an important role in the processes that keep us alive. We are born with two copies of every
gene - we inherit one copy from the father, and the other from the mother. The two genes interact
to make each of us a unique combination of our parents’ genetic identity.

Humans have 23 pairs of chromosomes, for a total of 46 chromosomes. Of these contain 22 pairs of
autosomes, which look the same in both men and women. However, the 23rd pair consists of one
allosome pair, the sex chromosome. Allosomes differ between males and females - males have an X
chromosome and a Y chromosome; females have two X chromosomes. These sex chromosomes
account for the biological differences between men and women.

Atoms Molecules Cells Tissues Organ Organ System Organism

Did you know? Mature red blood cells do not have DNA.

There are many different types of cells in the human body, such as nerve cells, hair cells, heart cells,
skin cells, and many more, all with different shapes and forms. The only human cells that do not
contain chromosome pairs are reproductive cells that carry just one copy of each chromosome.

Chromosomes vary in number and shape among living things - however, this doesn’t determine
how complex an organism is. For example, potatoes have 48 chromosomes - two more than
humans - but they’re certainly not more complex than us.

Different organisms also have different genes, which is ultimately why each organism looks and
functions uniquely. But one of the many reasons why scientists believe that all life on earth is
related, is that the basic DNA code – the language of A, C, T and G – is pretty much the same for
all living things. Many organisms even share some of the same genes as us. For example, any two
unrelated humans share 99.9% of their genes with one another. Humans and chimpanzees – who
are closely related – share 98.4% of their genetic code. Surprisingly, we also share roughly 50% of
our genes with bananas.

50%
7 of 84 Nature Vs Nurture

Nature Vs Nurture
Your genotype is the set of genes in your DNA which is responsible for a particular trait. The
phenotype is the physical expression, or characteristics, of that trait.

Most phenotypes are influenced by both your genotype and by the unique circumstances in which
you have lived your life, including everything that has ever happened to you. We often refer to these
as “nature” - the unique genome you carry - and “nurture” - the environment in which you have
lived.

In particular, diet and lifestyle factors are major environmental factors that influence the risks for
several common diseases such as diabetes, high blood pressure or high cholesterol. Importantly,
even if someone is at a high genetic risk for these common diseases, following a healthy diet and
lifestyle helps to reduce the risks. For example, studies have shown that high genetic risk for heart
disease can be reduced by 50% if a healthy diet and lifestyle are followed.

The graph on the right illustrates Diet & Lifestyle Poor Good

how lifestyle can impact the risk of

Heart Disease Risk

developing certain diseases over Even if you have

high genetic risk,
time. good diet and
lifestyle changes
can help to reduce
your heart disease
risk by 50%.

0 5 10 15 20

Years of Follow-Up

What is a genetic variation?

 Understanding Next Generation Sequencing 8 of 84

Understanding Next Generation

Sequencing
Humans have about 20,000 genes. Each gene is responsible for something your body needs - such as a pigment to
make your eye colour, or an enzyme to digest lactose. Scientists are discovering more and more aspects of the
human DNA that can help us understand more about our traits and disease risks.

A variation in the DNA sequence is known as a genetic variation. Some DNA variations have been linked to health
issues. Other DNA variations are not related to health, but they may indicate interesting aspects such as your
physical traits, personality traits or behavioural tendencies. For example, you may have never considered traits such
as the texture of your earwax and whether or not you’re likely to get grey hair prematurely are related to your DNA.

Next Generation sequencing stands as a revolutionary gene sequencing technology, offering a significant leap
forward in genetic testing. This technology is distinguished by several key advantages when compared to traditional
gene sequencing techniques.

Its high throughput capability allows it to process millions of DNA molecules simultaneously, generating a large
amount of sequence data in a short time. It also features high sensitivity, detecting DNA samples even at very low
concentrations for accurate results. Lastly, it provides high-resolution sequence data, revealing subtle DNA
variations.

Through next-generation sequencing technology, we can detect and analyze variations in genes that may influence
our health. While gene variations can cause health conditions, some variations may not cause any health problems
and could even be beneficial to our bodies.
9 of 84 Diet

Diet
Take full control of your diet and nutrition by unlocking everything there is to know about your
dietary DNA profile. Learn about your body’s sensitivity to many of the foods you eat, whether or not
you have certain dietary allergies, and the impact your genes may have on your ability to digest
certain food groups. Supported by genetically-guided consultations, turn your DNA insights into
actionable food decisions that make your body happy.
 Diet 10 of 84

Your Diet Report Results Summary

Your Optimal Diet Type

Healthy Balance Diet

YOU
Even those with no genetic food sensitivities should be
mindful of their diet to prevent common health risks. Cutting
back on saturated fats and processed carbs would help
anyone feel their best.

Alcohol Sensitivity Theophylline Sensitivity

Normal Sensitivity Normal Sensitivity

Normal Sensitivity Higher Sensitivity Normal Sensitivity Higher Sensitivity

Alcohol Flush Reaction Fat Sensitivity

Less Likely Normal Sensitivity

Less Likely Likely Normal Sensitivity Higher Sensitivity

Caffeine Sensitivity Carbohydrate Sensitivity

Higher Sensitivity Normal Sensitivity

Normal Sensitivity Higher Sensitivity Normal Sensitivity Higher Sensitivity

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
11 of 84 Diet

Your Diet Report Results Summary

Salt Sensitivity Detox: Cruciferous Vegetable Needs

Higher Sensitivity Increased

Normal Sensitivity Higher Sensitivity Normal Increased

Lactose Intolerance Detox: Toxin Generation Speed

Likely Tolerant Normal

Likely Tolerant Likely Intolerant Normal Increased

Spice Sensitivity
Higher Sensitivity

Normal Sensitivity Higher Sensitivity

Taste Sensitivity
Super-Taster

Non-Taster Super-Taster

Sweet Tooth
Higher Preference

Normal Preference Higher Preference

Weight Regain
Average Risk

Average Risk Elevated Risk

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Nutrition 12 of 84

Nutrition
We all metabolise nutrients differently based on our unique genetic make-up. Your body already
knows what it needs, and now you can too by taking the guesswork out of which supplements to
choose and which nutrient-dense foods to eat. Learn about how your DNA plays a role in your
body’s ability to absorb certain vitamins and minerals, so that you can take control of your long-
term health with personalised nutrient recommendations.
 13 of 84 Nutrition

Your Nutrition Report Results Summary

Antioxidants Iron
Higher Needs Higher Needs

Normal Needs Higher Needs Normal Needs Higher Needs

Biotin Magnesium
Normal Needs Higher Needs

Normal Needs Higher Needs Normal Needs Higher Needs

Calcium Niacin
Normal Needs Normal Needs

Normal Needs Higher Needs Normal Needs Higher needs

Co-enzyme Q10 Omega-3 (ALA)

Higher Needs Normal Needs

Normal Needs Higher Needs Normal Needs Higher Needs

Folic Acid Omega-3 (DHA)

Normal Needs Normal Needs

Normal Needs Higher Needs Normal Needs Higher Needs

Iodine Omega-3 (DPA)

Higher Needs Normal Needs

Normal Needs Higher Needs Normal Needs Higher Needs

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Nutrition 14 of 84

Your Nutrition Report Results Summary

Omega-3 (EPA) Vitamin B6

Normal Needs Normal Needs

Normal Needs Higher Needs Normal Needs Higher Needs

Phosphorus Vitamin C
Normal Needs Normal Needs

Normal Needs Higher Needs Normal Needs Higher Needs

Selenium Vitamin D
Higher Needs Normal Needs

Normal Needs Higher Needs Normal Needs Higher Needs

Vitamin A Vitamin E
Normal Needs Normal Needs

Normal Needs Higher Needs Normal Needs Higher Needs

Vitamin B12 Vitamin K

Normal Needs Higher Needs

Normal Needs Higher Needs Normal Needs Higher Needs

Vitamin B2 Zinc
Normal Needs Normal Needs

Normal Needs Higher Needs Normal Needs Higher Needs

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
15 of 84 Sports & Fitness

Sports & Fitness

Bridge the gap between your fitness and your DNA by discovering how your genes affect traits like
your exercise response, recovery rate, and injury risk. It’s here that you’ll also discover how to get the
very best out of your workouts, utilise your power and endurance profiles, as well as prevent any
serious injuries. Our professional fitness coaches are here to help you every step of the way.
 Sports & Fitness 16 of 84

Your Sports & Fitness Report Results Summary

Optimal Training Type

Consider the following:
Based on your genetic results, your body's bias towards
endurance and strength suggests that you could benefit from
training that places a greater focus on endurance and strength
based activities. We recommend allowing 80% of your training
schedule to be focused on endurance and strength based
activities, and letting the rest be power-based training.

Optimal Sports Type

Low Power
Consider the following:
Medium Endurance Tai chi, yoga, rock climbing

Medium Strength Based on your genetic results, you will likely respond well to
sports that have an endurance and strength focus.

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 17 of 84 Sports & Fitness

Your Sports & Fitness Report Results Summary

Risk of Achilles Tendon Injury Injury Risk

Very Low Elevated Risk

Very Low Lower Moderate Higher Very High Average Risk Elevated Risk

Blood Flow Lactate Clearance

Higher Below average

Normal Higher Below average Average Above average

Body Composition Lactate Production

Increased Lean Body Mass Below average

Normal Lean Increased Lean High Lean Body Below average Average Above average
Body Mass Body Mass Mass

Risk of Anterior Cruciate Ligament

Endurance Capacity Rupture
Medium
Lower

Low Medium High

Very Low Lower Moderate Higher Very High

Fatigue Resistance Exercise Associated Muscle Cramps

Average
Average

Below average Average Above average

Below average Average Above average

Heart Rate Response to Exercise Oxygen / VO₂ Efficiency

Average
Higher

Lower Average Higher

Normal Higher

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Sports & Fitness 18 of 84

Your Sports & Fitness Report Results Summary

Power Capacity
Low

Low Medium High

Recovery Efficiency
Normal Recovery

Lower Recovery Normal Recovery

Strength Profile
Medium

Low Medium High

Water Loss
Above average

Below average Average Above average

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
19 of 84 Wellbeing

Wellbeing
By looking at select genes and understanding their impact on your daily life, we can help you pave
the path to wellness and vitality. Identifying everything from your metabolic and inflammatory
response and life longevity, to your bone density and tendency to get mosquito bites - by
uncovering your genetic predisposition for certain conditions, you can potentially prevent them from
manifesting in the future.
 Wellbeing 20 of 84

Your Wellbeing Report Results Summary

Appetite Control Stress Fracture Risk

Normal Control Average Risk

Lower Control Normal Control Average Risk Elevated Risk

Bone Mineral Density

Likely Normal

Likely Lower Likely Normal

Inflammatory Response
Normal Response

Normal Response Increased Response

Life Longevity
Likely Average

Likely Average Likely Higher

Metabolic Response
Normal Response

Lower Response Normal Response

Tendency for Mosquito Bites

Higher Tendency

Normal Tendency Higher Tendency

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
21 of 84 Stress & Sleep

Stress & Sleep

Certain genes predispose some of us to be more sensitive to day-to-day stress than others. That’s
why effective stress management begins with understanding your body’s unique stress and sleep
profile. Find out whether you’re a ‘Warrior’ or a ‘Worrier’, a ‘Night Owl’ or a ‘Morning Lark’, and if
you’re genetically inclined towards getting better quality shut-eye, so that you can use the insights
to improve your mental and physical well-being.
 Stress & Sleep 22 of 84

Your Stress & Sleep Report Results Summary

Sleep Apnoea Risk Stress-Induced Obesity

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Moderate Risk Elevated Risk

Sleep Depth Stress Tolerance

Deep Sleeper Neutralist

Light Sleeper Average Sleeper Deep Sleeper Worrier Neutralist Warrior

Sleep Duration
Standard (7‑9 hours)

Short (<7 hours) Standard (7‑9 Long (>9 hours)

hours)

Sleep Movement
Average

Average More

Sleep Quality
Insomniac

Insomniac Easy Sleeper

Sleep Time (Chronotype)

Night Owl

Morning Lark Night Owl

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
23 of 84 Ancestry

Ancestry
Your DNA test offers you the powerful experience of discovering what makes you unique and
learning where you really come from. The places your ancestors called home are encoded in your
DNA. Ethnic groups historically come from the same geographic regions and draw from a local gene
pool. We analyse your DNA to determine your ancestral composition.
 Ancestry 24 of 84

Your Ancestry Report Results Summary

East Asian 33.78%

Chinese 33.78%

Northern Minority 22.55%

Western Minority 8.92%
Northern Han Chinese 2.31%
Southern Han Chinese 0%
Southern Minority 0%

Japanese & Korean 0%

European 32.79%

Eastern European 20.57%

Southern European 6.19%

Northern European 6.02%

Northwestern European 0%

Southeast Asian 21.02%

Indonesian, Thai, Malaysian,

13.75%
Filipino, Cambodian & Burmese

Vietnamese 7.27%

Middle Eastern 12.41%

African 0%

South Asian 0%

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
25 of 84 Skin

Skin
It’s difficult to predict how your skin will respond to ageing, but taking care of it based on what your
genes tell you will go a long way in preventing future skin damage. Understanding your unique skin
DNA profile helps to form the basis of your skin care routine - because not everyone’s skin is the
same.
 Skin 26 of 84

Your Skin Report Results Summary

Skin Age Stretch Marks

Mature Higher Tendency

Mature Normal Younger Lower Tendency Average Higher Tendency

Tendency

Acne Risk
Keloid Scars Risk
Very High
Average

Low Average High Very High

Average High

Glycation Risk
Skin Bruising Tendency
Low
Average Tendency

Low Average
Average Tendency Higher Tendency

Oxidative Stress Risk

Skin Detoxification Ability
Low
Average

Low Average High

Low Average

Cellulite Formation
Skin Hydration Ability
Higher Tendency
Normal Skin Hydration Factor

Lower Tendency Average Higher Tendency

Tendency Normal Skin Hydration Increased Skin Hydration
Factor Factor

Wrinkle Formation Risk

Skin Lightening Ability
Average
Lower Ability

Low Average High

Lower Ability Normal Ability

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
27 of 84 Skin

Your Skin Report Results Summary

Skin Photoaging Risk

Average

Low Average High

Hyperpigmentation Risk
Low

Low Average High

Sunburn Risk
Low

Low Average High

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Physical Traits 28 of 84

Physical Traits
Learning about how your DNA influences your appearance and senses is a fun and innovative way
to understand the science behind physical and sensory traits including hair colour, smell sensitivity
and earwax type. Discover how these traits run in your family and get answers to why you’re the
only one of your siblings with a particular trait.
 29 of 84 Physical Traits

Your Physical Traits Report Results Summary

Facial & Body Hair Hair Thickness

Likely Normal Likely Thicker

Likely Normal Likely More Than Normal Likely Thinner Likely Thicker

Body Odour (Bromhidrosis) Pain Sensitivity

Likely More Than Normal Likely Normal

Likely Normal Likely More Than Normal Likely Normal Likely Increased Likely High

Ear Protrusion Photic Sneeze Reflex

Less Likely Less Likely

Less Likely Likely Less Likely Likely

Earwax Type Smell Sensitivity

Likely Wet Likely Stronger

Likely Dry Likely Wet Likely Normal Likely Stronger

Eye Colour Sweat (Hyperhidrosis) Tendency

Likely Brown Likely More Than Normal

Likely Brown Likely Green Likely Blue Likely Normal Likely More Than Normal

Hair Colour Persistent Thinness

Likely Black Less Likely Thin

Likely Brown Likely Red Likely Black Likely Light Less Likely Thin Likely Thin

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Physical Traits 30 of 84

Your Physical Traits Report Results Summary

Waist Circumference
Likely Larger

Likely Average Likely Larger

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
31 of 84 Gender Traits

Gender Traits
Whether you are an artist creating new artifacts, a scientist making new discoveries or a gambler
making reckless bets may be partly programmed into your genes. Those who have what's known as
the "thrill-seeking" gene are likely to be more apt to take risks - and those who don't, tend to be
more risk-averse. What will your genes tell you about your "thrill-seeking" tendency?
 Gender Traits 32 of 84

Your Gender Traits Report Results Summary

Breast Size
Likely Average

Likely Average Likely Larger

Female Sex Hormone Levels

Likely Normal

Likely Normal Likely Elevated

Thrill-Seeking
Less Likely a Thrill-Seeker

Less Likely a Thrill-Seeker Thrill-Seeker

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
33 of 84 Behavioural Traits

Behavioural Traits
Discovering more about what makes you a unique human being is a combination of both your
genes (nature) and environment (nurture). Your genetics can affect your behaviour in different
situations - from your susceptibility towards alcohol, smoking and food addiction, to how charitable
you’re likely to be, as well as if you’re predisposed towards being more obsessive/compulsive than
others.
 Behavioural Traits 34 of 84

Your Behavioural Traits Report Results Summary

Alcohol Addiction
Less Likely

Less Likely More Likely

Altruism
Less Likely

Less Likely More Likely

Food Addiction
Less Likely

Less Likely More Likely

Obsessions With Washing/Cleaning

Less Likely

Less Likely More Likely

Smoking Addiction
Less Likely

Less Likely More Likely

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
35 of 84 Personality Traits

Personality Traits
If you’ve ever wondered about the links between your personality and your genes, wonder no more.
It’s here that you will learn about how your unique gene profile can offer a deeper look into the role
your DNA may play in how you think, feel, act, and react. Are you more extraverted and open than
others? Or do you tend to be more disciplined and organised? Your genes can tell you a lot about
the type of person you are.
 Personality Traits 36 of 84

Your Personality Traits Report Results Summary

Agreeableness
Likely Competitive / Challenging

Likely Likely Balanced Likely

Competitive / Compassionate /
Challenging Helpful

Conscientiousness
Likely Balanced

Likely Easy- Likely Balanced Likely Organised /

Going / Flexible Disciplined

Extraversion
Likely Reserved / Reflective

Likely Reserved / Likely Balanced Likely Energetic /

Reflective Outgoing

Neuroticism
Likely Confident / Calm

Likely Confident / Likely Balanced Likely Sensitive /

Calm Concerned

Openness
Likely Pragmatic / Consistent

Likely Pragmatic / Likely Balanced Likely Inventive /

Consistent Curious

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
37 of 84 Success Traits

Success Traits
Your likelihood of success in life could be written in your DNA. There is mounting evidence to show
that the best predictor of your life’s outcome isn’t just linked to your environment (i.e. your upbringing
and social class) but to your genetic make-up, too. From your intelligence quotient and
entrepreneurship tendency, to how good you’re likely to be at mathemathical skills - there’s a host
of exciting information contained in the genes that make you, you.
 Success Traits 38 of 84

Your Success Traits Report Results Summary

Intelligence Quotient (IQ) Language Ability

Excellent Excellent

Normal Excellent Gifted Normal Excellent Gifted

Emotional Quotient (EQ) Mathematical Skills

Gifted Normal

Normal Excellent Gifted Normal Excellent Gifted

Entrepreneurship Tendency (AQ) Memory Skills

Normal Normal

Normal Excellent Gifted Normal Excellent Gifted

Creativity
Normal

Normal Excellent Gifted

Educational Attainment
Normal

Normal Above Average High

Information Processing Power

Normal

Normal Excellent Gifted

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
39 of 84 Music & Dance

Music & Dance

No language is more universal than music. It's a part of the joy of life, which is why it’s found in
cultures across the world. However, how well we’re able to create it and dance to it is likely ingrained
in our DNA. Discover and celebrate the genetic possibilities of your hidden talents - and those of
your children - by uncovering your (and their) music and dance abilities, so that you can start to
nurture and master them.
 Music & Dance 40 of 84

Your Music & Dance Report Results Summary

Dancing Ability
Normal

Normal Gifted

Musical Ability
Normal

Normal Gifted

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
41 of 84 Pollution

Pollution
While air pollution is a major environmental concern that poses major health issues to the general
population, certain individuals are more genetically predisposed than others to get certain
respiratory conditions when exposed to certain airborne pollutants. Find out why prevention is
better than cure by knowing your genetic risk profile when it comes to the air you breathe.
 Pollution 42 of 84

Your Pollution Report Results Summary

Dust Allergy Sensitivity

Higher Sensitivity

Normal Sensitivity Higher Sensitivity

Pesticide Sensitivity
Normal Sensitivity

Normal Sensitivity Higher Sensitivity

Automobile Pollution Sensitivity

Higher Sensitivity

Normal Sensitivity Higher Sensitivity

Environmental Pollution Sensitivity

Higher Sensitivity

Normal Sensitivity Higher Sensitivity

Second-Hand Smoke Sensitivity

Normal Sensitivity

Normal Sensitivity Higher Sensitivity

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
43 of 84 Common Health Risks

Common Health
Risks
Most people with an inherited common disease risk don’t know they may already have the
condition, as they don’t experience symptoms. If left undetected and untreated, these types of
conditions can lead to problems such as heart disease and type 2 diabetes. While most disease
cases are caused by a combination of environmental conditions like pollution, and lifestyle choices
like an unhealthy diet, being overweight, smoking and drinking, some are due to genetics.

Certain inherited conditions like heart disease and stroke are passed down through families and are
caused by a change (or mutation) in one or more of your genes. Insights into your genetic risk for
certain diseases can help you and your healthcare provider build a personalised health plan to
manage the onset of various conditions.
 Common Health Risks 44 of 84

Your Common Health Risks Report Results Summary

Familial Hypercholesterolemia Stroke

Negative Average Risk

Negative Positive Average Risk Elevated Risk

Heart Disease Type 2 Diabetes

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

High Cholesterol
Average Risk

Average Risk Elevated Risk

Hypertension
Average Risk

Average Risk Elevated Risk

Non-Alcoholic Fatty Liver Disease

Elevated Risk

Average Risk Elevated Risk

Obesity
Average Risk

Average Risk Elevated Risk

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
45 of 84 Disease Risk

Disease Risk
Genetic risks for diseases are often identified too late. Limited health budgets also mean testing is
usually only offered to people diagnosed with genetic diseases and their families - not healthy
individuals. Targeted sequencing focuses on specific regions of human exome, which contains over
85% of disease causing mutations known today. It is the most revealing part of your genome, and a
cost-effective and compelling approach for uncovering disease genes.

Circle Disease Risk allows you to understand how your genetics may impact your risk of developing
certain health conditions. Our reports provide you with information and tools that aid your
understanding of potential health risks, including potential risks of complex illness, how certain
conditions may be passed on from generation-to-generation, as well as how you can take
preventable measures now to avoid these diseases manifesting later in life.
 Disease Risk 46 of 84

Your Disease Risk Report Results Summary

Glaucoma Abdominal Aortic Aneurysm

Elevated Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Hyperhomocysteinemia Attention Deficit Hyperactivity Disorder

Elevated Risk (ADHD)
Average Risk

Average Risk Elevated Risk

Average Risk Elevated Risk

Irritable Bowel Syndrome (IBS)

Elevated Risk Allergic Rhinitis
Average Risk

Average Risk Elevated Risk

Average Risk Elevated Risk

Opioid Addiction
Elevated Risk Allergies
Average Risk

Average Risk Elevated Risk

Average Risk Elevated Risk

Temporomandibular Joint Disorder

Elevated Risk Alopecia Areata
Average Risk

Average Risk Elevated Risk

Average Risk Elevated Risk

Tooth Decay
Elevated Risk Age-Related Macular Degeneration
(AMD)
Average Risk
Average Risk Elevated Risk

Average Risk Elevated Risk

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
47 of 84 Disease Risk

Your Disease Risk Report Results Summary

Ankylosing Spondylitis Autism

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Anxiety Disorder Androgenetic Alopecia

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Arrhythmogenic Right Ventricular Brugada Syndrome

Cardiomyopathy (ARVC) Average Risk

Average Risk

Average Risk Elevated Risk

Average Risk Elevated Risk

Catecholaminergic Polymorphic
Asthma Ventricular Tachycardia (CPVT)
Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Atopic Dermatitis Childhood Ear Infection

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Atrial Fibrillation Chronic Periodontitis

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Disease Risk 48 of 84

Your Disease Risk Report Results Summary

Cluster Headache Duodenal Ulcer

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Chronic Obstructive Pulmonary Disease Endometriosis

(COPD) Average Risk

Average Risk

Average Risk Elevated Risk

Average Risk Elevated Risk

Influenza (Flu) Susceptibility

Crohn's Disease Average Risk

Average Risk

Average Risk Elevated Risk

Average Risk Elevated Risk

Gallstone Disease
Deep Vein Thrombosis Average Risk

Average Risk

Average Risk Elevated Risk

Average Risk Elevated Risk

Gout
Major Depression Average Risk

Average Risk

Average Risk Elevated Risk

Average Risk Elevated Risk

High-Density Lipoprotein (HDL)

Dilated Cardiomyopathy (DCM) Cholesterol
Average Risk Likely Normal Levels

Average Risk Elevated Risk Likely Normal Levels Likely Lower Levels

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
49 of 84 Disease Risk

Your Disease Risk Report Results Summary

Hypertrophic Cardiomyopathy (HCM) Long QT Syndrome

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Hypothyroidism Lumbar Degenerative Disc Disease

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Idiopathic Pulmonary Fibrosis (IPF) Migraine

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Inflammatory Skin Disease Early Onset Myocardial Infarction

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Insulin Resistance and Response Non-Syndromic Hearing Loss

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Kidney Stones Noonan Syndrome

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Disease Risk 50 of 84

Your Disease Risk Report Results Summary

Orthostatic Hypotension Psoriatic Arthritis

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Osteoarthritis Rheumatoid Arthritis

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Osteoporosis Selective IgA deficiency

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Polycystic Ovary Syndrome Short QT Syndrome

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Elevated Risk

Peripheral Artery Disease Sitosterolemia

Average Risk Average Risk

Average Risk Elevated Risk Average Risk Risk for Mild Elevated Risk
Symptoms

Psoriasis
Syndromic Hearing Loss
Average Risk
Average Risk

Average Risk Elevated Risk

Average Risk Elevated Risk

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
51 of 84 Disease Risk

Your Disease Risk Report Results Summary

Thoracic Aortic Aneurysm and

Dissection
Average Risk

Average Risk Elevated Risk

Hypertriglyceridemia
Average Risk

Average Risk Elevated Risk

Ulcerative Colitis
Average Risk

Average Risk Elevated Risk

Vitiligo
Average Risk

Average Risk Elevated Risk

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Dementia & Brain Health 52 of 84

Dementia & Brain

Health
Research has found that many mental health disorders are caused by a combination of biological,
environmental, psychological, and genetic factors. In fact, a growing body of research has found
that certain genetic mutations are associated with some mental conditions. By better
understanding your risk of dementia and other brain conditions, you allow yourself to make
adjustments in your lifestyle that could reduce or delay the condition’s development later in life. It
also allows you to pass on this valuable information on to your loved ones so that they can also
mitigate their risk.
53 of 84 Dementia & Brain Health

Your Dementia & Brain Health Report Results Summary

Alzheimer's Disease
Average Risk

Average Risk Moderate Risk Elevated Risk

Bipolar Disorder
Average Risk

Average Risk Elevated Risk

Frontotemporal Dementia
Average Risk

Average Risk Elevated Risk

Lewy Body Dementia

Average Risk

Average Risk Elevated Risk

Parkinson's Disease
Average Risk

Average Risk Elevated Risk

Schizophrenia
Average Risk

Average Risk Elevated Risk

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Drug Response 54 of 84

Drug Response
From the moment medications enter your body, it’s actively working to process or metabolise them.
All drugs will eventually leave the body through a process called elimination - but the time they stay
active is often determined by genetic variations that change the way your drug-processing
enzymes work.

Certain genetic mutations can lead to unexpected or exaggerated responses to medications,

including severe complications and adverse drug reactions. Learn which medications and doses are
best suited to your condition and genetic make-up so that you can develop treatment strategies
and medication selections based on your specific DNA needs.

Understanding Your Results

We have grouped the drugs we tested into the seven different health conditions that they treat.
Your results provide information about how genes affect your response to different medications.

Poor Metaboliser Intermediate Metaboliser Normal Metaboliser Ultrarapid Metaboliser

Breaks down medications Breaks down medications Breaks down medications Breaks down medications
very slowly. May experience slowly. May have too much normally. Has normal very rapidly. May not get
side effects at normal medication at normal amounts of medication at enough medications at
doses. doses. normal doses. normal doses.

Medications are colour-coded into four categories

Use with Caution
Based on your genetic profile, you break down these medications very slowly and might have
too much medication at normal doses, likely resulting in an increased risk for developing adverse
drug reactions. Use medications with caution or consider an alternative drug.
Decrease Starting Dosage
Based on your genetic profile, you break down these medications slowly and might have too
much medication at normal doses, likely resulting in an increased risk for developing adverse
drug reactions. Medications may be used with decreased dosage.
Use as Directed
Based on your genetic profile, you break down these medications normally and might have
normal amounts of medications at normal doses, likely resulting in normal responses to these
medications. Medications may be used as directed per package insert.
Increase Starting Dosage
Based on your genetic profile, you break down these medications too quickly and might not get
enough medication at normal doses, likely resulting in suboptimal therapeutic response to these
medications. Medications can be used with increased dosage.

Limitations
This report provides information about how genes included in the Circle Drug Response Test affect your response to drugs. It combines
pharmacology (the science of drugs) and genomics (the study of genes) for the safe and effective use of medications and doses tailored
to your DNA. We recommend you share your results with your healthcare provider for further advice and to tailor your current or future
treatment plan.
 55 of 84 Drug Response

Your Psychiatric Report Results Summary

The Psychiatric Drug panel examines how your genes may affect your metabolism and response to FDA-approved medications
commonly prescribed to treat psychiatric conditions such as anxiety and mood disorders, etc.

USE AS DIRECTED ^ Prodrug: Medication that is metabolised into a

pharmacologically active compound within the body.
Antipsychotic
* FDA, CPIC, DPWG professional body guideline or
amisulpride significant clinical evidence.
aripiprazole [1] Might have greater weight gain. Closely monitor the
chlorpromazine adverse effects.
olanzapine
paliperidone
quetiapine
ziprasidone

Others
bupropion

SSRI
citalopram
escitalopram
sertraline
BZP
clobazam
diazepam
midazolam

SNRI
duloxetine

Stimulant
methylphenidate

MAOI
moclobemide

Opioid Antagonist
naloxone
naltrexone
Anticonvulsant
valproic acid1

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Drug Response 56 of 84

Your Cardiovascular Report Results Summary

The Cardiovascular Drug panel examines how your genes may affect your metabolism and response to FDA-approved medications
commonly prescribed to treat cardiovascular conditions such as hypertension (high blood pressure), hyperlipidemia (high cholesterol)
and heart disease, etc.

USE AS DIRECTED ^ Prodrug: Medication that is metabolised into a

pharmacologically active compound within the body.
CCB ACEI
* FDA, CPIC, DPWG professional body guideline or
amlodipine enalapril3 significant clinical evidence.
verapamil [1] *Might have a better response to specific statin.
ARB
Closely monitor the LDL level.
Beta Blocker losartan
[2] *Might have higher on-treatment ADP-induced
atenolol olmesartan platelet aggregation and lower levels of clopidogrel
carvedilol telmisartan active metabolite.
valsartan [3] Might have a smaller percent reduction in left
Statin
ventricular mass index. Closely monitor the response to
atorvastatin1 enalapril.
fluvastatin [4] Might have decreased reduction in fasting LDL-C.
lovastatin
[5] Might have decreased response in heart failure.
pravastatin6
rosuvastatin [6] Might benefit less from pravastatin treatment. Closely
monitor the response to pravastatin.
simvastatin7
[7] *Consider initiating simvastatin at desired starting
Diuretic dose and adjust doses based on disease-specific
guidelines.
bumetanide
furosemide [8] Recommended warfarin doses to achieve a
therapeutic INR based on CYP2C9 and VKORC1
hydrochlorothiazide genotype using the warfarin product insert approved by
Antiplatelet the US Food and Drug Administration, CPIC Guidelines
and Eur J Clin Pharmacol (2007) 63: 1135-1141
clopidogrel ^2
prasugrel
ticagrelor
Antiarrhythmic
digoxin

DECREASE STARTING DOSAGE

Anticoagulant
warfarin8

USE WITH CAUTION

Fibrate
fenofibrate4

Others
hydralazine5

Nitrate
isosorbide mononitrate5

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 57 of 84 Drug Response

Your Diabetes Report Results Summary

The Diabetes Drug panel examines how your genes may affect your metabolism and response to FDA-approved medications
commonly prescribed to treat diabetes and other diabetes related complications.

USE AS DIRECTED ^ Prodrug: Medication that is metabolised into a

pharmacologically active compound within the body.
Statin
* FDA, CPIC, DPWG professional body guideline or
atorvastatin1 significant clinical evidence.
fluvastatin [1] *Might have a better response to specific statin.
lovastatin Closely monitor the LDL level.
pravastatin4 [2] Might have a smaller percent reduction in left
rosuvastatin ventricular mass index. Closely monitor the response to
simvastatin5 enalapril.
[3] Might have decreased reduction in fasting LDL-C.
ACEI
[4] Might benefit less from pravastatin treatment. Closely
enalapril2 monitor the response to pravastatin.
SU [5] *Consider initiating simvastatin at desired starting
dose and adjust doses based on disease-specific
glibenclamide guidelines.
gliclazide
glimepiride
glipizide
ARB
losartan
olmesartan
telmisartan
valsartan
Biguanide
metformin
TZD
pioglitazone
Meglitinide
repaglinide

USE WITH CAUTION

Fibrate
fenofibrate3

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Drug Response 58 of 84

Your Pain Report Results Summary

The Pain Drug panel examines how your genes may affect your metabolism and response to FDA-approved medications commonly
prescribed to treat acute and chronic pain.

USE AS DIRECTED ^ Prodrug: Medication that is metabolised into a

pharmacologically active compound within the body.
TNF Inhibitor Opioid Antagonist
* FDA, CPIC, DPWG professional body guideline or
adalimumab naloxone significant clinical evidence.
etanercept naltrexone [1] *Might have decreased opioid analgesic requirement
infliximab after surgery.
Others
Opioid [2] *Might have increased likelihood of methotrexate
paracetamol3 induced toxicity.
alfentanil
Anaesthetic [3] Might have increased risk of liver failure in OD cases.
methadone
propofol [4] Might have increased response to rocuronium when
NSAID placed under anesthesia.
Anticonvulsant [5] Might have a lower likelihood of achieving remission of
celecoxib
diclofenac valproic acid7 rheumatoid arthritis.
flurbiprofen [6] Might be less likely to have reduced pain or attack
ibuprofen frequency.
indomethacin [7] Might have greater weight gain. Closely monitor the
adverse effects.
meloxicam
naproxen
SNRI
duloxetine

DMARD
methotrexate2

DECREASE STARTING DOSAGE

Opioid
buprenorphine1
fentanyl1
morphine1

Neuromuscular Blocker
rocuronium4

USE WITH CAUTION

Others
sulfasalazine5

Triptan
sumatriptan6

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 59 of 84 Drug Response

Your Commonly Prescribed Drugs Report Results Summary

The Commonly Prescribed Drugs panel examines how your genes may affect your metabolism and response to FDA-approved
medications commonly prescribed to treat disease conditions such as common cold and cough, allergy and acid reflux, etc.

USE AS DIRECTED ^ Prodrug: Medication that is metabolised into a

pharmacologically active compound within the body.
Bisphosphonate Antimicrobial
* FDA, CPIC, DPWG professional body guideline or
alendronate daptomycin significant clinical evidence.
risedronate dicloxacillin [1] *Might have a better response to specific statin.
erythromycin Closely monitor the LDL level.
Statin
voriconazole [2] *Literatures have shown that individuals who are
atorvastatin1 CYP2C19 normal metabolizer might have decreased
fluvastatin Antihistamine drug response with standard dosing.
lovastatin fexofenadine [3] *Might have increased likelihood of methotrexate
pravastatin7 induced toxicity.
SU
rosuvastatin [4] *Might have decreased opioid analgesic requirement
simvastatin9 glibenclamide after surgery.
gliclazide
Others [5] Might have increased risk of liver failure in OD cases.
glimepiride
carisoprodol glipizide [6] For adults only, female undergoing cesarean delivery
might require an increased dose of phenylephrine.
paracetamol5
Biguanide [7] Might benefit less from pravastatin treatment. Closely
NSAID metformin monitor the response to pravastatin.
celecoxib [8] *Might be less likely to have positive erectile response.
DMARD Closely monitor the response to sildenafil.
diclofenac
flurbiprofen methotrexate3 [9] *Consider initiating simvastatin at desired starting
ibuprofen dose and adjust doses based on disease-specific
Anticonvulsant guidelines.
indomethacin
valproic acid10 [10] Might have greater weight gain. Closely monitor the
meloxicam
adverse effects.
naproxen

INCREASE STARTING DOSAGE

PPI
dexlansoprazole2
esomeprazole2
lansoprazole2
omeprazole2
pantoprazole2
rabeprazole2

Others
phenylephrine6

DECREASE STARTING DOSAGE

Opioid
morphine4

USE WITH CAUTION

PDE 5 Inhibitor
sildenafil8

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Drug Response 60 of 84

Your Paediatrics Report Results Summary

The Paediatrics Drug panel examines how your genes may affect your metabolism and response to FDA-approved medications
commonly prescribed to treat paediatric conditions.

USE AS DIRECTED ^ Prodrug: Medication that is metabolised into a

pharmacologically active compound within the body.
Antipsychotic Stimulant
* FDA, CPIC, DPWG professional body guideline or
aripiprazole methylphenidate significant clinical evidence.
olanzapine [1] *Might have decreased short term response to inhaled
LTRA
paliperidone corticosteroids as measured by FEV after 6 weeks of
quetiapine montelukast treatment.
ziprasidone Others [2] *Literatures have shown that individuals who are
3
CYP2C19 normal metabolizer might have decreased
ICS paracetamol drug response with standard dosing.
budesonide1 Barbiturate [3] Might have increased risk of liver failure in OD cases.
fluticasone1 [4] For adults only, female undergoing cesarean delivery
phenobarbital
triamcinolone1 might require an increased dose of phenylephrine.
SABA [5] Might have greater weight gain. Closely monitor the
SSRI
salbutamol adverse effects.
citalopram
escitalopram LABA
sertraline salmeterol
Antimicrobial Anticonvulsant
daptomycin valproic acid5
dicloxacillin
erythromycin
voriconazole
BZP
diazepam
Antihistamine
fexofenadine
NSAID
ibuprofen

INCREASE STARTING DOSAGE

PPI
dexlansoprazole2
esomeprazole2
lansoprazole2
omeprazole2
pantoprazole2
rabeprazole2

Others
phenylephrine4

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 61 of 84 Drug Response

Your Geriatrics Report Results Summary

The Geriatrics Drug panel examines how your genes may affect your metabolism and response to FDA-approved medications
commonly prescribed to treat geriatric conditions.

USE AS DIRECTED ^ Prodrug: Medication that is metabolised into a

pharmacologically active compound within the body.
TNF Inhibitor ARB
* FDA, CPIC, DPWG professional body guideline or
adalimumab losartan significant clinical evidence.
etanercept olmesartan [1] *Might have a better response to specific statin.
infliximab telmisartan Closely monitor the LDL level.
valsartan [2] Might have a smaller percent reduction in left
Bisphosphonate
ventricular mass index. Closely monitor the response to
alendronate Biguanide enalapril.
risedronate metformin [3] Might have an increased risk for adverse reactions,
including hallucinations and dyskinesia, when treated
Beta Blocker Antipsychotic with levodopa.
atenolol olanzapine [4] Might have decreased clearance of the drug.
carvedilol quetiapine
[5] Might have lower response rate in Chinese.
Statin TZD [6] Might benefit less from pravastatin treatment. Closely
atorvastatin1 pioglitazone monitor the response to pravastatin.
fluvastatin [7] *Consider initiating simvastatin at desired starting
AChEI dose and adjust doses based on disease-specific
lovastatin
rivastigmine guidelines.
pravastatin6
rosuvastatin Anticholinergic
simvastatin7
tiotropium
ACEI
enalapril2

COMT Inhibitor
entacapone

SU
glibenclamide
gliclazide
glimepiride
glipizide
Dopamine Precursor
levodopa3

DECREASE STARTING DOSAGE

NMDA Antagonist
memantine4

USE WITH CAUTION

Dopamine Agonist
pramipexole5

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Cancer Risk 62 of 84

Cancer Risk
Circle Cancer Risk determines whether or not you carry inherited genetic mutations that may
increase your risk of developing cancer. Having an early awareness of your genetic predisposition
towards certain cancers can monumentally affect the outcome of your health, by allowing you to
create a personalised plan designed to help prevent or detect cancer at an earlier and more
treatable stage. In fact, 5-10% of cancers are due to inherited genetic mutations. Most of the
inherited cancer conditions follow an autosomal dominant mode of inheritance. So, one person is
enough to pass on the cancer-causing mutation from one generation to another.

However, it’s important to note that while having a mutation may increase your risk of cancer, this
test is not a cancer diagnosis and does not mean you will necessarily develop the disease. For
example, most men have a 2% chance of getting colorectal cancer by the age of 70, while a man
with a genetic mutation in the MLH1 gene can have a 35% chance. The level of increased risk differs
from gene-to-gene and from cancer-to-cancer. This information can help your healthcare provider
give you actionable steps towards preventive and early screening measures.

Understanding Your Results

There are three possible types of results:

No cancer-causing mutation was detected.

This suggests that the laboratory did not find any specific pathogenic mutations the test was
designed to detect. However, other factors also influence your risk of developing cancer. A genetic
counsellor can help you understand how both genetic and non-genetic factors may influence your
risk of developing cancer.

A cancer-causing mutation was detected.

This suggests that a genetic mutation associated with an increased cancer susceptibility was
detected in the genes tested. It is important to follow up with a doctor or a genetic counsellor, since
there may be preventive options that are effective in reducing cancer risk.

A clinically significant genetic mutation detected.

This suggests that a clinically significant mutation was detected in the genes tested - however, this
genetic mutation is not currently linked to an increased cancer risk in females. We do still
recommend following up with a doctor or a genetic counsellor to better understand your cancer
risk.

Limitations
This report provides information about your genetic predisposition to the specific types of cancer included in the Circle Cancer Risk Test
Report. Environmental and lifestyle factors also often play a large role in your risk for developing cancer. The information presented in the
Circle Cancer Risk Test Report is not intended as medical advice and should not be used for diagnosing, treating or preventing diseases.
Please consult with your healthcare provider for further advice before making any changes to your diet or lifestyle.
63 of 84 Cancer Risk

Your Cancer Risk Report Results Summary

Bladder Cancer
No cancer-causing mutation was detected.
2 gene(s) tested

Brain Cancer
No cancer-causing mutation was detected.
16 gene(s) tested

Breast Cancer
No cancer-causing mutation was detected.
15 gene(s) tested

Carcinoid
No cancer-causing mutation was detected.
2 gene(s) tested

Chondrosarcoma
No cancer-causing mutation was detected.
4 gene(s) tested

Colorectal Cancer
No cancer-causing mutation was detected.
27 gene(s) tested

Esophageal Cancer
No cancer-causing mutation was detected.
1 gene(s) tested

Fanconi Anemia Related Cancers

No cancer-causing mutation was detected.
5 gene(s) tested

Gastro-Intestinal Stromal Tumour

No cancer-causing mutation was detected.
5 gene(s) tested

Kidney Cancer
No cancer-causing mutation was detected.
8 gene(s) tested

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Cancer Risk 64 of 84

Your Cancer Risk Report Results Summary

Leukaemia
No cancer-causing mutation was detected.
23 gene(s) tested

Liver Cancer
No cancer-causing mutation was detected.
9 gene(s) tested

Lung Cancer
No cancer-causing mutation was detected.
3 gene(s) tested

Lymphoma
No cancer-causing mutation was detected.
12 gene(s) tested

Melanoma
No cancer-causing mutation was detected.
20 gene(s) tested

Meningioma
No cancer-causing mutation was detected.
7 gene(s) tested

Multiple Myeloma
No cancer-causing mutation was detected.
1 gene(s) tested

Neuroblastoma
No cancer-causing mutation was detected.
6 gene(s) tested

Neurofibroma
No cancer-causing mutation was detected.
1 gene(s) tested

Osteosarcoma
No cancer-causing mutation was detected.
4 gene(s) tested

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
65 of 84 Cancer Risk

Your Cancer Risk Report Results Summary

Ovarian Cancer
No cancer-causing mutation was detected.
13 gene(s) tested

Pancreatic Cancer
No cancer-causing mutation was detected.
17 gene(s) tested

Paraganglioma
No cancer-causing mutation was detected.
10 gene(s) tested

Parathyroid Cancer
No cancer-causing mutation was detected.
1 gene(s) tested

Pheochromocytoma
No cancer-causing mutation was detected.
12 gene(s) tested

Pituitary Adenoma
No cancer-causing mutation was detected.
3 gene(s) tested

Retinoblastoma
No cancer-causing mutation was detected.
2 gene(s) tested

Rhabdomyosarcoma
No cancer-causing mutation was detected.
6 gene(s) tested

Skin Basal Cell Cancer

No cancer-causing mutation was detected.
11 gene(s) tested

Skin Squamous Cell Cancer

No cancer-causing mutation was detected.
15 gene(s) tested

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Cancer Risk 66 of 84

Your Cancer Risk Report Results Summary

Stomach Cancer
No cancer-causing mutation was detected.
15 gene(s) tested

Thyroid Cancer
No cancer-causing mutation was detected.
9 gene(s) tested

Uterine Cancer
No cancer-causing mutation was detected.
10 gene(s) tested

Uveal Melanoma
No cancer-causing mutation was detected.
1 gene(s) tested

Wilms Tumour
No cancer-causing mutation was detected.
10 gene(s) tested

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 67 of 84 Family Planning

Family Planning
Circle Family Planning (carrier screening) can determine whether or not you or your partner carry
inherited genetic mutations that you might pass on to an unborn child. Knowing this information
before you get pregnant, or early in your pregnancy, can make a difference in your family’s well-
being.

Your DNA contains two copies of every gene — one inherited from your mother, and one from your
father. These genes pass along family characteristics like hair and eye color. They also sometimes
pass on inherited conditions.

Most people carry at least one pathogenic mutation in a gene included in our Family Planning
Screen. This usually only becomes an issue if both you and your partner have a pathogenic
mutation in one copy of the same gene. When this happens, even though neither of you have any
symptoms, there is a 1-in-4 chance for each pregnancy that your child will be affected by the
condition associated with the gene. With this information, your healthcare provider can give you
actionable steps you can take to prevent your child from having the condition.

Understanding Your Results

There are four possible types of results:

Negative Positive: Carrier

This suggests that no disease-causing mutation was This suggests that a disease-causing mutation was
detected amongst the genes tested for the analysed detected amongst the genes tested for the analysed
condition. condition. Symptoms are generally not seen in carriers
but there may be an increased risk of passing down
the genetic disease to your child.

Positive: At Risk for Symptoms Positive: Likely Affected

This suggests that a disease-causing mutation was This suggests that a disease-causing mutation was
detected amongst the genes tested for the analysed detected amongst the genes tested for the analysed
condition. Risk of symptoms may be present for you condition. Risk of symptoms may be present for you,
and your child, and there may also be an increased and there may be an increased risk of passing down
chance your child may develop the condition. the genetic condition to your child.

Limitations
This report provides information about your genetic predisposition to the specific types of conditions included in the Circle Family Planning
Test Report. The information presented in the Circle Family Planning Test Report is not intended as medical advice and should not be used
for diagnosing, treating or preventing diseases. Please consult with your healthcare provider for further advice before making any
changes to your diet or lifestyle.
 Family Planning 68 of 84

Your Family Planning Report Results Summary

Achondrogenesis
Negative
Due to SLC26A2 Mutation

Achromatopsia
Negative
Due to ATF6 Mutation

Achromatopsia
Negative
Due to CNGA3 Mutation

Achromatopsia
Negative
Due to CNGB3 Mutation

Achromatopsia
Negative
Due to GNAT2 Mutation

Achromatopsia
Negative
Due to PDE6C Mutation

Achromatopsia
Negative
Due to PDE6H Mutation

Acute Fatty Liver

Negative
Due to HADHA Mutation

Alkaptonuria
Negative
Due to HGD Mutation

Alpha-Mannosidosis
Negative
Due to MAN2B1 Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
69 of 84 Family Planning

Your Family Planning Report Results Summary

Alpha-Sarcoglycanopathy
Negative
Due to SGCA Mutation

Alpha-1 Antitrypsin Deficiency

Negative
Due to SERPINA1 Mutation

Andermann Syndrome
Negative
Due to SLC12A6 Mutation

Aspartylglycosaminuria
Negative
Due to AGA Mutation

Ataxia-Telangiectasia
Negative
Due to ATM Mutation

Ataxia with Vitamin E Deficiency

Negative
Due to TTPA Mutation

Autosomal Recessive Hypophosphatasia

Negative
Due to ALPL Mutation

Autosomal Recessive Muscular dystrophy

Negative
Due to CAPN3 Mutation

Autosomal Recessive Muscular dystrophy

Negative
Due to CAV3 Mutation

Autosomal Recessive Muscular dystrophy

Negative
Due to DYSF Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Family Planning 70 of 84

Your Family Planning Report Results Summary

Autosomal Recessive Muscular dystrophy

Negative
Due to FKTN Mutation

Autosomal Recessive Polycystic Kidney Disease

Negative
Due to PKHD1 Mutation

Autosomal Recessive Spastic Ataxia of

Charlevoix-Saguenay (ARSACS) Negative
Due to SACS Mutation

Bardet-Biedl Syndrome
Negative
Due to BBS1 Mutation

Bardet-Biedl Syndrome
Negative
Due to BBS10 Mutation

Beta-sarcoglycanopathy (Limb-girdle muscular

dystrophy) Negative
Due to SGCB Mutation

Beta Chain-Related Hemoglobinopathy

Negative
Due to HBB Mutation

Biotinidase Deficiency
Negative
Due to BTD Mutation

Bloom Syndrome
Negative
Due to BLM Mutation

Canavan Disease
Negative
Due to ASPA Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
71 of 84 Family Planning

Your Family Planning Report Results Summary

Carnitine Palmitoyltransferase Deficiency

Negative
Due to CPT1A Mutation

Carnitine Palmitoyltransferase Deficiency

Negative
Due to CPT2 Mutation

Cartilage-hair Hypoplasia
Negative
Due to RMRP Mutation

Choroideremia
Negative
Due to CHM Mutation

Citrullinemia
Negative
Due to ASS1 Mutation

Citrullinemia
Negative
Due to SLC25A13 Mutation

Cohen Syndrome
Negative
Due to VPS13B Mutation

Combined Pituitary Hormone Deficiency

Negative
Due to PROP1 Mutation

Congenital Adrenal Hyperplasia

Negative
Due to CYP17A1 Mutation

Congenital Disorder of Glycosylation

Negative
Due to MPI Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Family Planning 72 of 84

Your Family Planning Report Results Summary

Congenital Disorder of Glycosylation

Negative
Due to PMM2 Mutation

Costeff Optic Atrophy Syndrome

Negative
Due to OPA3 Mutation

Cystic Fibrosis
Negative
Due to CFTR Mutation

Cystinosis
Negative
Due to CTNS Mutation

D-bifunctional Protein Deficiency

Negative
Due to HSD17B4 Mutation

Deafness
Negative
Due to PCDH15 Mutation

Diastrophic Dysplasia
Negative
Due to SLC26A2 Mutation

Dihydrolipoamide Dehydrogenase Deficiency

Negative
Due to DLD Mutation

Dihydropyrimidine Dehydrogenase Deficiency

Negative
Due to DPYD Mutation

Dilated Cardiomyopathy
Negative
Due to FKTN Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
73 of 84 Family Planning

Your Family Planning Report Results Summary

Factor XI Deficiency
Negative
Due to F11 Mutation

Familial Dysautonomia
Negative
Due to ELP1 Mutation

Familial Mediterranean Fever

Negative
Due to MEFV Mutation

Fanconi Anemia
Negative
Due to FANCA Mutation

Fanconi Anemia
Negative
Due to FANCC Mutation

Fanconi Anemia
Negative
Due to FANCG Mutation

Galactosemia
Negative
Due to GALT Mutation

Gaucher Disease
Negative
Due to GBA Mutation

Glucose-6-phosphate Dehydrogenase
Deficiency Negative
Due to G6PD Mutation

Glutaric Acidemia
Negative
Due to GCDH Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Family Planning 74 of 84

Your Family Planning Report Results Summary

Glycogen Storage Disease

Negative
Due to AGL Mutation

Glycogen Storage Disease

Negative
Due to G6PC Mutation

Glycogen Storage Disease

Negative
Due to PYGM Mutation

Glycogen Storage Disease

Negative
Due to SLC37A4 Mutation

GRACILE Syndrome
Negative
Due to BCS1L Mutation

HELLP Syndrome
Negative
Due to HADHA Mutation

Hemophilia B
Negative
Due to F9 Mutation

Hereditary Fructose Intolerance

Negative
Due to ALDOB Mutation

Herlitz Junctional Epidermolysis Bullosa

Negative
Due to LAMA3 Mutation

Herlitz Junctional Epidermolysis Bullosa

Negative
Due to LAMB3 Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
75 of 84 Family Planning

Your Family Planning Report Results Summary

Herlitz Junctional Epidermolysis Bullosa

Negative
Due to LAMC2 Mutation

Hexosaminidase A Deficiency (Including Tay-

Sachs Disease) Negative
Due to HEXA Mutation

HFE-associated Hereditary Hemochromatosis

Negative
Due to HFE Mutation

Homocystinuria
Negative
Due to CBS Mutation

Hyperinsulinism
Negative
Due to ABCC8 Mutation

Hyperinsulinism
Negative
Due to HADH Mutation

Hyperinsulinism
Negative
Due to KCNJ11 Mutation

Inclusion Body Myopathy

Negative
Due to GNE Mutation

Isovaleric Acidemia
Negative
Due to IVD Mutation

Joubert Syndrome
Negative
Due to TMEM216 Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Family Planning 76 of 84

Your Family Planning Report Results Summary

Krabbe Disease
Negative
Due to GALC Mutation

LCHAD Deficiency
Negative
Due to HADHA Mutation

Maple Syrup Urine Disease

Negative
Due to BCKDHA Mutation

Maple Syrup Urine Disease

Negative
Due to BCKDHB Mutation

Maple Syrup Urine Disease

Negative
Due to DBT Mutation

Maple Syrup Urine Disease

Negative
Due to DLD Mutation

Medium Chain Acyl-CoA Dehydrogenase

Deficiency Negative
Due to ACADM Mutation

Megalencephalic Leukoencephalopathy with

Subcortical Cysts Negative
Due to MLC1 Mutation

Metachromatic Leukodystrophy
Negative
Due to ARSA Mutation

Methylmalonic Acidemia
Negative
Due to MMAA Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
77 of 84 Family Planning

Your Family Planning Report Results Summary

Methylmalonic Acidemia
Negative
Due to MMAB Mutation

Methylmalonic Acidemia
Negative
Due to MMUT Mutation

MTHFR Deficiency
Negative
Due to MTHFR Mutation

Mucolipidosis
Negative
Due to MCOLN1 Mutation

Mucopolysaccharidosis
Negative
Due to IDUA Mutation

Muscle-Eye-Brain Disease
Negative
Due to POMGNT1 Mutation

Muscular dystrophy-dystroglycanopathy
Negative
Due to FKTN Mutation

Nemaline Myopathy
Negative
Due to KLHL40 Mutation

Nemaline Myopathy
Negative
Due to NEB Mutation

Neuronal Ceroid Lipofuscinosis

Negative
Due to CLN3 Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Family Planning 78 of 84

Your Family Planning Report Results Summary

Neuronal Ceroid Lipofuscinosis

Negative
Due to CLN5 Mutation

Neuronal Ceroid Lipofuscinosis

Negative
Due to PPT1 Mutation

Neuronal Ceroid Lipofuscinosis

Negative
Due to TPP1 Mutation

Niemann-Pick Disease
Negative
Due to NPC1 Mutation

Niemann-Pick Disease
Negative
Due to SMPD1 Mutation

Nijmegen Breakage Syndrome

Negative
Due to NBN Mutation

Nonsyndromic Hearing Loss and Deafness

Negative
Due to GJB2 Mutation

Nonsyndromic Hearing Loss and Deafness

Negative
Due to GJB3 Mutation

Nonsyndromic Hearing Loss and Deafness

Negative
Due to MT-RNR1 Mutation

Northern Epilepsy
Negative
Due to CLN8 Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
79 of 84 Family Planning

Your Family Planning Report Results Summary

Oculocutaneous Albinism
Negative
Due to TYR Mutation

Pendred Syndrome
Negative
Due to SLC26A4 Mutation

Phenylketonuria
Negative
Due to GCH1 Mutation

Phenylketonuria
Negative
Due to GCHFR Mutation

Phenylketonuria
Negative
Due to PAH Mutation

Phenylketonuria
Negative
Due to PCBD1 Mutation

Phenylketonuria
Negative
Due to PTS Mutation

Phenylketonuria
Negative
Due to QDPR Mutation

Polyglandular Autoimmune Syndrome

Negative
Due to AIRE Mutation

Pompe Disease
Negative
Due to GAA Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Family Planning 80 of 84

Your Family Planning Report Results Summary

Primary Carnitine Deficiency

Negative
Due to SLC22A5 Mutation

Primary Hyperoxaluria
Negative
Due to AGXT Mutation

Primary Hyperoxaluria
Negative
Due to GRHPR Mutation

Primary Hyperoxaluria
Negative
Due to HOGA1 Mutation

Pseudocholinesterase Deficiency
Negative
Due to BCHE Mutation

Pycnodysostosis
Negative
Due to CTSK Mutation

Recessive Multiple Epiphyseal Dysplasia

Negative
Due to SLC26A2 Mutation

Rhizomelic Chondrodysplasia Punctata

Negative
Due to PEX7 Mutation

Salla Disease
Negative
Due to SLC17A5 Mutation

Segawa Syndrome
Negative
Due to TH Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
81 of 84 Family Planning

Your Family Planning Report Results Summary

Short Chain Acyl-CoA Dehydrogenase

Deficiency Negative
Due to ACADS Mutation

Sickle Cell Disease

Negative
Due to HBB Mutation

Sjögren-Larsson Syndrome
Negative
Due to ALDH3A2 Mutation

Smith-Lemli-Opitz Syndrome
Negative
Due to DHCR7 Mutation

Steroid-resistant Nephrotic Syndrome

Negative
Due to COQ8B Mutation

Steroid-resistant Nephrotic Syndrome

Negative
Due to CUBN Mutation

Steroid-resistant Nephrotic Syndrome

Negative
Due to LAMB2 Mutation

Steroid-resistant Nephrotic Syndrome

Negative
Due to LMX1B Mutation

Steroid-resistant Nephrotic Syndrome

Negative
Due to NPHS1 Mutation

Steroid-resistant Nephrotic Syndrome

Negative
Due to NPHS2 Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Family Planning 82 of 84

Your Family Planning Report Results Summary

Steroid-resistant Nephrotic Syndrome

Negative
Due to PLCE1 Mutation

Steroid-resistant Nephrotic Syndrome

Negative
Due to SMARCAL1 Mutation

Steroid-resistant Nephrotic Syndrome

Negative
Due to WT1 Mutation

Sulfate Transporter-related
Osteochondrodysplasia Negative
Due to SLC26A2 Mutation

Trifunctional Protein Deficiency

Negative
Due to HADHA Mutation

Tyrosinemia
Negative
Due to FAH Mutation

Usher Syndrome
Negative
Due to ADGRV1 Mutation

Usher Syndrome
Negative
Due to CDH23 Mutation

Usher Syndrome
Negative
Due to CIB2 Mutation

Usher Syndrome
Negative
Due to CLRN1 Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
83 of 84 Family Planning

Your Family Planning Report Results Summary

Usher Syndrome
Negative
Due to MYO7A Mutation

Usher Syndrome
Negative
Due to PCDH15 Mutation

Usher Syndrome
Negative
Due to PDZD7 Mutation

Usher Syndrome
Negative
Due to USH1C Mutation

Usher Syndrome
Negative
Due to USH1G Mutation

Usher Syndrome
Negative
Due to USH2A Mutation

Usher Syndrome
Negative
Due to WHRN Mutation

Very Long Chain Acyl-CoA Dehydrogenase

Deficiency Negative
Due to ACADVL Mutation

Wilson Disease
Negative
Due to ATP7B Mutation

X-linked Juvenile Retinoschisis

Negative
Due to RS1 Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14
 Family Planning 84 of 84

Your Family Planning Report Results Summary

Zellweger Syndrome Spectrum

Negative
Due to PEX1 Mutation

Customer: Logan Phillips

Date of Birth: 27/11/2024
Gender: Female
Report Date: 30/01/2025 13:47
Sample ID: 2701-4065-3700-14