UNIVERSITY OF MADRAS
B.Sc. DEGREE PROGRAMME IN MICROBIOLOGY
SYLLABUS WITH EFFECT FROM 2023-2024
Marks
Credits
Subject Inst.
Subject Name Category L T P S
Code Hours CIA Exter- Total
nal
236C4A Immunology and Core Course – VII Y - - - 5 5 25 75 100
Immunotechnology
Course Objectives
CO1 To gain knowledge about immune system, organs of immunity and cells involved.
CO2 To distinguish the types of antigens and antibodies; their properties.
CO3 To provide in-depth knowledge on immuno-techniques.
CO4 To discuss the role of MHC system in transplantation; functions of Tumor specific antigens.
CO5 To impart knowledge on immunological disorders.
Unit Details No.of Hours Course
Objectives
I Organs and Cells of Immune System: Primary lymphoid organs, 12 CO1
secondary lymphoid organs, and lymphoid tissues, T cell - TCR, B
cell – BCR, granulocytic cells, antigen presenting cells. Immune
Response – Mechanism and Physiology of Immune Response -
Innate, Humoral and Cell mediated immunity.
Immunohematology.
II Antigen and Antibody: Antigens – Types, properties and 12 CO2
functions, Haptens and Adjuvants. Antibodies - structure,
properties and classes. Antigen and Antibody Reactions –
precipitation and agglutination, Vaccines – Active and passive
immunization and types of vaccines. Other approaches to new
vaccines and vaccination schedule.
III Immunoassay and Immunotechniques - Preparation and 12 CO3
standardization of bacterial antigens; Raising of monoclonal and
polyclonal antibodies; Purification of antibodies.
Immunotechniques – RIA, RAST, ELISA, Immunofluorescence
techniques, Flow Cytometry..
IV Major Histocompatibility Complex (MHC) - MHC Antigens - 12 CO4
structure and function; HLA system. Transplantation Immunology
- tissue transplantation and grafting; Mechanism of graft
acceptance and rejection; HLA typing and Tumor Immunology -
tumor specific antigens, immune diagnosis; cancer immune
therapy.
V Immunological disorders and diseases - Hypersensitivity reactions 12 CO5
(Type I, II, III and IV). Auto immune disorders and diseases:
organ specific and systemic.
Total 60
UNIVERSITY OF MADRAS
B.Sc. DEGREE PROGRAMME IN MICROBIOLOGY
SYLLABUS WITH EFFECT FROM 2023-2024
Course Outcomes
Course On completion of this course, students will;
Outcomes
CO1 Assess the fundamental concepts of immunity, contributions of the PO1, PO4, PO6, PO9,
organs and cells in immune responses.
CO2 Investigate the structures of Ag and Ab; Immunization. PO1, PO4, PO5, PO9
CO3 Justify the Immunoassay and Immunotechniques. PO1, PO4, PO5, PO7
CO4 Explain about the immunologic processes governing graft PO1, PO3, PO4, PO5,
rejection and therapeutic modalities for immunosuppression in PO9
transplantation
CO5 Analyze the overreaction by our immune system leading to PO1, PO4, PO5, PO6
hypersensitive conditions and its consequences.
Text Books
1. Richard Coico, Geoffrey Sunshine, Eli Benjamini. (2003). Immunology – A Short Course.
5thEdition., Wiley-Blackwell, New York.
2. Judith A.Owen, Jenni Punt, Sharon A. Stranford, Janis Kuby. (2013). Immunology,
7thEdition., W. H. Freeman and Company, New York.
3. Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai. (2021). Cellular and Molecular
Immunology, 10thEdition., Elsevier.
4. Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Harry Schroeder, Anthony J.
Frew, Cornelia M. Weyand. (2018).Clinical Immunology: Principles and Practice, 5th Edition.
Elsevier.
5. Pravash Sen. Gupta. (2003). Clinical Immunology. Oxford University Press.
References Books
1 Janeway Travers. (1997). Immunobiology- the immune system in health and disease. Current
Biology Ltd. London, New York. 3rd Edition.
2 Peter J. Delves, Seamus Martin, Dennis R. Burton, Ivan M. Roitt. (2006). Roitt’s Essential
Immunology, 11thEdition., Wiley-Blackwell.
3 William R Clark. (1991). The Experimental Foundations of Modern Immunology. 3rdEdition.
John Wiley and Sons Inc. New York.
4 Frank C. Hay, Olwyn M. R. Westwood. (2002). Practical Immunology, 4thEdition., Wiley-
Blackwell.
5 Noel R. Rose, Herman Friedman, John L. Fahey. (1986). Manual of Clinical Laboratory
Immunology. ASM.3rd Edition.
Web Resources
1 https://www.ncbi.nlm.nih.gov/books/NBK279395/
2 https://med.stanford.edu/immunol/phd-program/ebook.html
3 https://ocw.mit.edu/courses/hst-176-cellular-and-molecular-immunology-fall-
2005/pages/lecture-notes/
4 Immunology Overview - Medical Microbiology - NCBI Bookshelf (nih.gov)
5 Immunology - an overview | ScienceDirect Topics
UNIVERSITY OF MADRAS
B.Sc. DEGREE PROGRAMME IN MICROBIOLOGY
SYLLABUS WITH EFFECT FROM 2023-2024
Methods of Evaluation
Continuous Internal Assessment Test
Internal Assignments
25 Marks
Evaluation Seminars
Attendance and Class Participation
External
End Semester Examination 75 Marks
Evaluation
Total 100 Marks
Methods of Assessment
Recall (K1) Simple definitions, MCQ, Recall steps, Concept definitions
Understand/
MCQ, True/False, Short essays, Concept explanations, Short summary or
Comprehend
overview
(K2)
Application Suggest idea/concept with examples, Suggest formulae, Solve problems,
(K3) Observe, Explain
Problem-solving questions, Finish a procedure in many steps, Differentiate
Analyze (K4)
between various ideas, Map knowledge
Evaluate
Longer essay/ Evaluation essay, Critique or justify with pros and cons
(K5)
Check knowledge in specific or offbeat situations, Discussion, Debating or
Create (K6)
Presentations
Mapping with Programme Outcomes:
PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9
CO1 S M S M
CO2 S M M M
CO3 S S S S
CO4 S M S S M
CO5 S S M M
