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Replication

RNA is considered the first genetic material and plays a crucial role in various life processes, although it is reactive and unstable, leading to the evolution of DNA as the primary genetic material. The process of DNA replication, proposed by Watson and Crick as semiconservative, was experimentally confirmed by Meselson and Stahl, and further supported in eukaryotes by Taylor and colleagues using radioactive thymidine in Faba beans. The document outlines the molecular basis of inheritance, highlighting the transition from RNA to DNA and the mechanisms of replication.

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saiesh kolambkar
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21 views7 pages

Replication

RNA is considered the first genetic material and plays a crucial role in various life processes, although it is reactive and unstable, leading to the evolution of DNA as the primary genetic material. The process of DNA replication, proposed by Watson and Crick as semiconservative, was experimentally confirmed by Meselson and Stahl, and further supported in eukaryotes by Taylor and colleagues using radioactive thymidine in Faba beans. The document outlines the molecular basis of inheritance, highlighting the transition from RNA to DNA and the mechanisms of replication.

Uploaded by

saiesh kolambkar
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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MOLECULAR BASIS OF

INHERITANCE
RNA WORLD
• RNA is first genetic material (found in viruses)
EX: QB bacteriophage and TMV virus
• RNA dominate living systems :
• Many life processes evolved around RNA
(i) metabolism
(ii) translation
(iii) splicing
• Act as catalyst : RNA enzyme (non- protein enzyme)

• RNA REACTIVE AND UNSTABLE (not suitable to be genetic material)


• DNA evolved from RNA
REPLICATION
• Process of formation of new DNA copy from the existing DNA molecule

• WATSON AND CRICK proposed scheme of DNA replication (1953)


SEMICONSERVATIVE DNA REPLICATION
Experimental proof :SEMICONSERVATIVE DNA REPLICATION
• BY: MATTHEW MESELSON AND FRANKLYN STAHL
Proof in eukaryotes
• TAYLOR and colleagues

• In Faba beans (Vicia faba) – Radioactive THYMIDINE


REPLICATION : machinery and enzymes

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