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Drug-Drug Interactions

The document outlines various drug interactions that pharmacists must be aware of, highlighting the risks associated with combinations such as Metronidazole and Warfarin, which can lead to fatal bleeding. It also mentions the effects of certain drugs like Ondansetron and Fluconazole, as well as the importance of Vitamin D supplements for breastfeeding infants. Overall, it emphasizes the critical nature of understanding these interactions to ensure patient safety.

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ngmngm509
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9 views5 pages

Drug-Drug Interactions

The document outlines various drug interactions that pharmacists must be aware of, highlighting the risks associated with combinations such as Metronidazole and Warfarin, which can lead to fatal bleeding. It also mentions the effects of certain drugs like Ondansetron and Fluconazole, as well as the importance of Vitamin D supplements for breastfeeding infants. Overall, it emphasizes the critical nature of understanding these interactions to ensure patient safety.

Uploaded by

ngmngm509
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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DRUGS

INTERACTIONS
If you are a pharmacist must know
Metronidazole inhibits the
Metronidazole metabolism of warfarin by
+ blocking CYP2C9 may lead to
Warfarin
fatal bleeding.

Furosemide
+ Leads to hearing loss.
Gentamycin

Sildenafil Both causes Vasodilation,


+ Severe hypotension and
Sublingual
Nitroglycerin maybe death.

Non
dihydropyridine Both cause Severe
(Verapamil, Bradycardia and heart
Diltiazem)
+ block.
Beta Blockers

Tetracyclines are bacteriostatic,


Tetracyclines Inhibits growth of bacteria while
+ penicillin work only on actively
Penicillins
dividing organisms.
Antacids or Anti-
Ulcer Iron needs acidic to be
+ absorbed.
Iron In pt. with IDA

Omeprazole decreases effect


Omeprazole of clopidogral by affecting
+ Hepatic enzyme CYP2CI9
Clopidogral
metabolism.

Azithromycin Severe Chest pain and


+
Antihistamines prolong QT intervals.

Ondansetron Ondansetron decreases


+ analgesic effect of tramadol.
Tramadol

Warfarin Increase the risk of GIT


+ bleeding.
NSAIDs
K sparing
diuretics Leads to hyperkalemia.
+
ACEI (Captopril)

Statin
+ Increase risk of myopathy.
Gemfibrozil

Ciprofloxacin, These drugs are CYP450


Cimitidine, Fluvoxamine,
Clarithromycin, inhibitors leads to inc. in
Erythromycin Theophylline level in blood
+
Theophylline leading to death.

Ondansetron is the most safest and


most effective anti-emetic in children.

Fluconazole (Antifungal) must be taken


with fatty meal to increase absorption.

All breastfeeding baby's should receive


Vit.D supplements til the age of 1 year.
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