Ethos therapy redefines

personalized cancer care

An Adaptive Intelligence™ solution

Radiation treatment used to mean delivering the radiation each

day exactly as originally planned, regardless of patient changes
over the course of therapy. If organs shifted or the target changed
size or shape, creating a new plan was too resource-intensive and
time-consuming to undertake. That was yesterday.
 Product Brief | Ethos™

Ethos therapy transforms cancer care with Adaptive Intelligence. It is the

long-awaited solution that puts each patient truly at the center of care. For the
first time, radiation oncologists have powerful yet simple tools to achieve their
intention for each patient, each and every day. They can see changes in patient
anatomy, adapt the treatment plan within minutes, and deliver it, all within a
typical 15-minute treatment timeslot. Online adaptive therapy is no longer an
elusive aspiration, too complex and time-consuming to be practical and too ex-
clusive for most clinics and patients. True to the Ethos name, this revolutionary
therapy is within reach now for every cancer patient in virtually every hospital
and cancer center. Welcome to the Ethos community and the exciting future of
adaptive therapy.
 Product Brief | Ethos™

Removing the barriers to Streamlined adaptive workflow

adaptive therapy At each treatment, Ethos therapy will:
The foundation of Ethos therapy is Adaptive • V
 isualize today's anatomy with Iterative
Intelligence, which uniquely integrates advanced CBCT images
multimodality images and artificial intelligence,
enabling clinicians to see more, know more, and • A
 ccess diagnostic-quality CT, PET and MR
treat more precisely. A revolution in personalized images at the treatment console
cancer care might be expected to increase • Create AI aided contours in seconds
complexity. But not with Ethos therapy. Ethos
• C
 alculate the dose for the scheduled plan on
therapy is so intuitive to use that we believe it
today’s anatomy
can be adopted in virtually any clinic or hospital.
No additional specialized staff or intensive • Create AI-driven adapted treatment plans
new training is required. Information for making which take full advantage of the dual layer
decisions is presented in a structured, contextually MLC, high dose rate, rapid gantry rotation, and
logical, and easy to understand manner. state of the art treatment delivery
• E
 valuate treatment plans against the
New levels of visibility physician’s intent
Ethos therapy integrates Iterative CBCT and • P
 erform patient specific quality assurance
multimodality diagnostic quality images at the closely coupled with the Mobius quality
point of treatment on the treatment console. assurance platform
By providing the most current view of patient
• D
 eliver treatment on a platform designed to
anatomy in exquisite detail, Ethos therapy gives
enhance flexibility in patient positioning and
clinicians confidence that adapted plans are
comfort while ensuring high staff satisfaction
based on high quality imaging.
and productivity
• E
 very step of the workflow is optimized for
speed and safety
 Product Brief | Ethos™

Simplified decision-making Familiar, efficient QA

guided by AI QA for Ethos therapy follows a familiar
Ethos therapy takes the complexity out of workflow that saves time and resources while
adaptive planning and enables decisions in enhancing confidence in results.
minutes. • Independent adaptive plan QA can be
Each day, the clinician selects the plan—original performed on-demand without impeding
or adapted—that meets his or her intent. Ethos treatment workflow
therapy facilitates dose delivery to the target • N
 o additional staff or training is required for
as planned, helps to spare organs at risk, and Ethos therapy commissioning or QA
enables more customized margins to potentially
reduce toxicity. • Initial planning and adaptive planning at
the console use the same algorithms for
• Information is structured hierarchically for a consistency
more robust decision-making process
• Intuitive decision tree guides the entire
adaptive therapy workflow
• T
 reatment management and treatment
planning applications are tightly coupled and
context-aware

Flexibility in delivery techniques

Ethos therapy enables clinicians to assess
techniques and choose the one that is most
appropriate for the patient.
• S
 upports both VMAT and sliding window
IMRT
• O
 n-couch adaption, off-couch adaption, or
no adaption
 The Ethos community
Adaptive therapy is no longer the exclusive province of
large academic centers. Ethos therapy makes personalized
adaptive therapy attainable for most centers and most
patients. Welcome to the Ethos community and the future
of personalized cancer care.

Intended Use Summary

Varian Medical Systems’ linear accelerators are intended to provide stereotactic radiosurgery and precision radiotherapy for lesions, tumors, and conditions anywhere in the body
where radiation treatment is indicated.
Important Safety Information
Radiation treatments may cause side effects that can vary depending on the part of the body being treated. The most frequent ones are typically temporary and may include,
but are not limited to, irritation to the respiratory, digestive, urinary or reproductive systems, fatigue, nausea, skin irritation, and hair loss. In some patients, they can be severe.
Treatment sessions may vary in complexity and time. Radiation treatment is not appropriate for all cancers.

USA, Corporate Authorized Representative

Headquarters and in the EU
Manufacturer
varian.com Varian Medical Systems
Varian Medical Systems Nederland B.V.
Palo Alto, CA Houten, The Netherlands
Tel: 650.424.5700 customer.relations@varian.com
800.544.4636

Headquarters Europe, Asia Pacific Headquarters Australasian Headquarters Latin American Headquarters
Eastern Europe, Middle &
Varian Medical Systems Varian Medical Systems Varian Medical Systems
Near East, India, Africa
Pacific, Inc. Australasia Pty Ltd. Brasil Ltda.
Varian Medical Systems Kowloon, Hong Kong Sydney, Australia São Paulo, Brasil
International AG Tel: 852.2724.2836 Tel: 61.2.9485.0111 Tel: 55.11.3457.2655
Stienhausen, Switzerland
Tel: 41.41.749.8844

510(k) pending—Not available for sale in all jurisdictions

Varian Medical Systems as a medical device manufacturer cannot and does not recommend specific treatment approaches.
Specifications subject to change without notice.
Not all features or products are available in all markets and are subject to change.

© 2019 Varian Medical Systems,Inc. All rights reserved. Varian and Varian Medical Systems are registered trademarks and Ethos therapy, Eclipse treatment
planning system, and Halcyon system are trademarks of Varian Medical Systems, Inc. The names of other companies and products mentioned herein are
used for identification purposes only and may be trademarks or registered trademarks of their respective owners.

RAD10688 09/2019