Laks Bio Project
Laks Bio Project
ACKNOWLEDGEMENT
                         1
                INDEX
3 Types of Allergies 5
  4           Environmental Allergies             7
  5             Drug Allergies                    8
6 Insect Allergies 9
  7              Other Allergies                 10
  8    Pathophysiology of Allergic Reactions     11
9 Immediate Phase 13
10 Role of Mediators 14
11 Common Allergens 16
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                       Introduction
                                   3
   The Immune System's Role in Allergies
                                    4
                    Types of Allergies
Food Allergies
Food allergies occur when the immune system mistakenly identifies
certain proteins in food as harmful, leading to an allergic reaction. Some
of the most common food allergens include:
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Seafood: Shellfish (including shrimp, crab, and lobster) and fish
allergies are common, especially among adults. These allergies can lead
to severe reactions, and individuals may need to avoid all forms of
seafood, including cross contamination with cooking utensils or
equipment.
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                  Environmental Allergies
Environmental allergies are triggered by allergens found in the
environment. They can be classified into two categories: seasonal and
perennial allergies.
Seasonal Allergies
Seasonal allergies, also known as hay fever or allergic rhinitis, are often
caused by pollen from trees, grasses, and weeds. These allergens are
prevalent during specific seasons, leading to symptoms such as
sneezing, nasal congestion, itchy eyes, and fatigue. Common pollen
triggers include:
   •   Tree Pollen: Generally, peaks in spring.
   •   Grass Pollen: Most common in late spring and early summer.
   •   Weed Pollen: Common in late summer and fall.
Perennial Allergies
Perennial allergies occur year-round and are often caused by indoor
allergens such as:
   •   Dust Mites: Microscopic organisms found in bedding, carpets,
       and upholstered furniture. Dust mite allergies are prevalent, with
       studies indicating that approximately 20 million Americans are
       affected.
   •   Mold: Fungi that thrive in damp environments, both indoors and
       outdoors. Mold spores can trigger allergic reactions, particularly
       in individuals with asthma.
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                            Drug Allergies
                                   8
                               Insect Allergies
Insect allergies are triggered by stings or bites from specific insects, and
they can result in serious allergic reactions. Common insect allergens
include:
   •    Bees: Honeybee and bumblebee stings can cause severe allergic
        reactions in sensitive individuals, potentially leading to
        anaphylaxis. Approximately 2 million Americans are at risk of
        life-threatening reactions to insect stings.
   •    Wasps and Hornets: Stings from wasps and hornets can also
        provoke allergic reactions, and individuals allergic to one type of
        stinging insect may be allergic to others.
   •    Fire Ants: In some regions, fire ant stings are particularly
        problematic, causing painful reactions and potential anaphylaxis.
Individuals with insect allergies are often advised to carry epinephrine
auto-injectors and wear medical identification to alert others in case of
an emergency
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                      Other Allergies
                                   10
Pathophysiology of Allergic Reactions
Mechanisms of Sensitization
Sensitization is the process by which the immune system becomes
overly reactive to a typically harmless substance, known as an allergen.
The sensitization process can be divided into several key steps:
    1. Initial Exposure: The individual is first exposed to an allergen,
       such as pollen, pet dander, or certain foods. During this exposure,
       the allergen is processed by antigen-presenting cells (APCs),
       which are primarily dendritic cells.
    2. Activation of T-helper Cells: The APCs present the allergen to
       naïve T-cells, leading to their differentiation into T-helper (Th) 2
       cells. These cells play a critical role in promoting the allergic
       response by producing cytokines.
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    3. IgE Production: In response to cytokines produced by Th2 cells,
       B-cells are activated and differentiate into plasma cells that
       produce Immunoglobulin E (IgE) antibodies specific to the
       allergen. This IgE binds to the surface of mast cells and basophils,
       sensitizing them to the allergen.
    4. Re-exposure: Upon subsequent exposure to the same allergen,
       the allergen cross-links the IgE on the surface of mast cells and
       basophils,        leading        to        their      activation.
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                    Immediate Phase
Delayed Phase
The delayed phase occurs several hours after re-exposure and involves
a more sustained response. Key features include:
   Recruitment of Inflammatory Cells: The immediate release of
   mediators leads to the recruitment of additional inflammatory cells,
   including eosinophils, neutrophils, and T-cells to the site of allergen
   exposure.
   Sustained Symptoms: The delayed phase can result in prolonged
   symptoms, such as:
         o   Prolonged nasal congestion
         o   Skin rashes
         o   Asthma exacerbations
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             Role of Mediators
Various mediators play crucial roles in the allergic response. Key
mediators include:
Histamines
Histamines are stored in mast cells and are among the first mediators
released during an allergic reaction. They cause:
   •   Vasodilation: Increased blood flow to the area leads to redness
       and warmth.
   •   Increased Vascular Permeability: This causes fluid leakage,
       resulting in swelling and enema.
   •   Smooth Muscle Contraction: Histamines can lead to
       bronchoconstriction, causing difficulty breathing in individuals
       with asthma.
Leukotrienes
Leukotrienes are lipid mediators produced by mast cells, eosinophils,
and other immune cells. They contribute to:
   •   Bronchoconstriction: Similar to histamines, leukotrienes can
       cause constriction of airway smooth muscles.
   •   Increased Mucus Production: They promote mucus secretion,
       leading to airway obstruction.
   •   Recruitment of Inflammatory Cells: Leukotrienes attract
       eosinophils and other inflammatory cells to the site of allergen
       exposure.
Cytokines
Cytokines are signalling proteins produced by immune cells that play
diverse roles in the immune response. In allergies, Th2 cytokines, such
as IL-4, IL-5, and IL-13, are particularly important:
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   •   IL-4: Promotes B-cell class switching to produce IgE antibodies.
   •   IL-5: Stimulates the growth and activation of eosinophils, which
       are involved in chronic allergic inflammation.
   •   IL-13: Contributes to mucus production and airway
Anaphylaxis
Anaphylaxis is a severe, life-threatening allergic reaction that occurs
rapidly and requires immediate medical attention. Key points include:
Causes
Anaphylaxis can be triggered by various allergens, including:
   •   Foods (e.g., peanuts, tree nuts, shellfish)
   •   Medications (e.g., penicillin, nonsteroidal anti-inflammatory
       drugs)
   •   Insect stings (e.g., bees, wasps)
   •   Latex exposure
Symptoms
Symptoms of anaphylaxis can occur within minutes and may include:
   •   Skin reactions (hives, swelling)
   •   Respiratory issues (shortness of breath, wheezing)
   •   Cardiovascular symptoms (rapid heartbeat, low blood pressure)
   •   Gastrointestinal symptoms (nausea, vomiting)
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                   Common Allergens
Food Allergens
Food allergies are immune responses to specific proteins found in certain
foods. The major food allergens, often referred to as the "big eight,"
include:
1. Peanuts
   •   Source: Peanuts are legumes that grow underground. They are
       commonly found in snacks, candies, and sauces.
   •   Allergic Reactions: Reactions can range from mild symptoms,
       such as hives and swelling, to severe anaphylaxis.
2. Tree Nuts
   •   Source: Common tree nuts include almonds, walnuts, hazelnuts,
       cashews, pistachios, and Brazil nuts. They are often found in
       baked goods, granola bars, and trail mixes.
   •   Allergic Reactions: Similar to peanut allergies, reactions can be
       severe, with symptoms like difficulty breathing and anaphylaxis.
3. Milk
   •   Source: Cow's milk is the primary allergenic source, commonly
       found in dairy products such as cheese, yogurt, and butter.
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4. Eggs
     •    Source: Eggs, particularly egg whites, are found in many baked
          goods, dressings, and may be present in vaccines.
     •    Allergic Reactions: Reactions may manifest as skin rashes,
          respiratory problems, or gastrointestinal symptoms.
5. Wheat
     •    Source: Wheat is a common ingredient in bread, pasta, and many
          processed foods.
     •    Allergic Reactions: Symptoms can include hives, asthma, and
          anaphylaxis, although many people may have gluten intolerance
          or celiac disease, which are different from wheat allergies.
6. Soy
     •    Source: Soybeans are found in various forms, including tofu, soy
          milk, and as an ingredient in processed foods.
     •    Allergic Reactions: Symptoms can range from mild to severe,
          similar to other food allergies.
7. Fish
     •    Source: Common fish allergens include salmon, tuna, and cod.
          Fish is often found in seafood dishes and fish sauces.
     •    Allergic Reactions: Fish allergies can cause severe reactions,
          often leading to anaphylaxis.
8. Shellfish
 •       Source: Shellfish include crustaceans (e.g., shrimp, crab) and
         molluscs (e.g., clams, oysters). They are prevalent in seafood
         cuisine.
 •       Allergic Reactions: Shellfish allergies are often severe and can
         trigger anaphylaxis.
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Environmental Allergens
Environmental allergens are substances in the environment that can
trigger allergic reactions. They can be categorized into pollen and indoor
allergens.
Pollen Allergens
Pollen is a common environmental allergen, particularly during specific
seasons.
   1. Tree Pollen: Trees such as oak, cedar, and birch release pollen in
      the spring. Symptoms include sneezing, itchy eyes, and nasal
      congestion.
   2. Grass Pollen: Grass pollen is prevalent in late spring and early
      summer. Common grasses include Bermuda, Timothy, and
      Kentucky bluegrass.
   3. Weed Pollen: Weeds like ragweed, sagebrush, and pigweed
      release pollen in late summer and fall, causing similar allergic
      symptoms.
Chemical Allergens
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Chemical allergens are substances commonly found in household
products that can provoke allergic reactions. Key examples include:
   1. Fragrances: Many personal care products, air fresheners, and
      cleaning products contain fragrances that can trigger allergic
      reactions and asthma symptoms.
   2. Preservatives: Some preservatives used in food and cosmetics
      (e.g., sulphites, parabens) can cause allergic reactions in sensitive
      individuals.
   3. Latex: Natural rubber latex, found in gloves, balloons, and some
      medical devices, can cause allergic reactions ranging from mild
      skin irritation to anaphylaxis.
   4. Household Cleaners: Chemicals in cleaning products (e.g.,
      bleach, ammonia) can cause skin irritation, respiratory problems,
      and allergic reactions in some individuals.
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Summary of common symptoms
                                                  Examples of
Category           Common Symptoms
                                                  Allergens
                                   20
                 Symptom Overview
Allergic reactions can lead to a wide range of symptoms that can be
categorized into three main types: respiratory, skin, and
gastrointestinal.
1. Respiratory Symptoms
Respiratory symptoms are among the most common manifestations of
allergies, particularly in cases of allergic rhinitis and asthma. Key
symptoms include:
   •   Sneezing: A reflex action to clear irritants from the nasal
       passages.
   •   Nasal Congestion: Swelling of nasal passages, leading to
       difficulty breathing through the nose.
   •   Runny Nose (Rhinorrhoea): Increased mucus production that
       can lead to a clear or coloured nasal discharge.
   •   Itchy Eyes (Allergic Conjunctivitis): Irritation of the eyes,
       often accompanied by redness and tearing.
   •   Coughing: A reflex to clear airways, often caused by post-nasal
       drip or asthma.
   •   Wheezing and Shortness of Breath: Common in asthma, these
       symptoms result from airway constriction.
2. Skin Symptoms
Skin-related allergic reactions can vary in severity and presentation.
Common skin symptoms include:
   •   Hives (Urticaria): Raised, itchy welts that can appear anywhere
       on the body, often triggered by food allergies or insect stings.
   •   Eczema (Atopic Dermatitis): A chronic skin condition
       characterized by dry, itchy, and inflamed skin, often exacerbated
       by environmental allergens.
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   •   Angioedema: Swelling beneath the skin, often around the eyes
       and lips, that can occur with hives.
3. Gastrointestinal Symptoms
Gastrointestinal symptoms are particularly relevant in cases of food
allergies. Key symptoms include:
   •   Nausea and Vomiting: Common reactions to food allergens,
       which can occur shortly after ingestion.
   •   Diarrheal: Frequent, watery stools can result from food
       allergies.
   •   Abdominal Pain or Cramping: Discomfort that can accompany
       nausea or diarrhoea.
Understanding these symptoms helps individuals identify potential
allergic reactions and seek appropriate medical attention.
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                       Diagnostic Methods
Accurate diagnosis of allergies is essential for effective treatment.
Several diagnostic methods are commonly used:
1. Skin Prick Tests
   •   Procedure: A small amount of allergen extract is applied to the
       skin (usually the forearm or back) using a prick or scratch. If the
       person is allergic, a raised, red bump (wheal) will develop at the
       site within 15-20 minutes.
   •   Uses: Skin prick tests are commonly used to diagnose allergies
       to pollen, pet dander, dust mites, and certain foods.
   •   Advantages: This test is quick, relatively inexpensive, and
       provides immediate results.
2. Blood Tests (IgE Levels)
   •   Procedure: A blood sample is taken and analysed for specific
       IgE antibodies to various allergens. Elevated levels of IgE
       specific to a particular allergen indicate sensitization.
   •   Uses: Blood tests are useful when skin testing is not feasible
       (e.g., in cases of severe eczema, or when a person is taking
       antihistamines).
   •   Advantages: They provide a more comprehensive view of
       allergen sensitivities and can measure IgE levels quantitatively.
3. Patch Tests
   •   Procedure: Allergen substances are applied to patches that are
       placed on the skin (usually on the back) for 48 hours. The skin is
       then examined for reactions.
   •   Uses: Patch tests are primarily used to diagnose contact
       dermatitis, a delayed allergic reaction to substances such as
       nickel, fragrances, and preservatives.
   •   Advantages: This test helps identify specific allergens causing
       skin reactions.
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        Challenges in Diagnosis
                                     24
            Management and Treatment
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   •   Topical Corticosteroids: Hydrocortisone cream can relieve
       localized skin symptoms, such as hives or eczema.
   •   Oral Corticosteroids: Prednisone may be prescribed for severe
       allergic reactions or exacerbations, but long-term use is
       generally avoided due to potential side effects.
3. Bronchodilators
Bronchodilators are primarily used for asthma management and can
help relieve wheezing and shortness of breath associated with allergic
reactions.
   •   Short-acting Beta-Agonists (SABAs): Ibuterol (Proventil) is a
       commonly used inhaler that provides quick relief during an
       asthma attack.
   •   Long-acting Beta-Agonists (LABAs): Medications like
       salmeterol (Serevent) may be used for long-term asthma control
       but are not effective for immediate relief.
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       Lifestyle Modifications
                                    27
               Avoidance Techniques
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           preparation methods. It’s advisable to choose restaurants
           known for accommodating allergies.
•   Seasonal Allergies: Individuals should monitor pollen counts
    through local weather reports. On high pollen days, it’s best to
    stay indoors, keep windows closed, and use air conditioning to
    filter indoor air.
       o   Indoor Allergens: Regular cleaning can help minimize
           dust mites, Mold, and pet dander. Using HEPA filters in
           vacuum cleaners and air purifiers can effectively reduce
           airborne allergens. Washing bedding and curtains in hot
           water frequently can also help eliminate dust mites.
•   Chemical Allergens:
       o   Product Selection: For those allergic to certain
           chemicals, selecting hypoallergenic and fragrance-free
           products can minimize exposure. It’s essential to check
           labels on personal care items and household cleaners for
           potential allergens.
       o   Ventilation: Proper ventilation during the use of
           household cleaners and chemicals can help reduce
           inhalation of airborne irritants.
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               Education and Awareness
                                    30
                     Public Health Initiatives
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                       Final Thoughts
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             BIBLIOGRAPHY
•   https://www.niaid.nih.gov
•   https://www.mayoclinic.org
•   https://e-aair.org
•   NCERT Books Class 12
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