KasturiShikshanSanstha
COLLEGE OF PHARMACY, SHIKRAPUR
Approved by PCI, DTE ,MSBTE and Affiliated to SPPU & DBATU
(Id No. PU/PN/B. Pharm/290/2008)
Pratima Nagar, Pune-Nagar Road Shikrapur, Tal: Shirur, Dist: Pune- 412208(MS)
Subject: Subject code: Subject In charge:
BIOPHARMACEUTICS AND
PHARMACOKINETICS [THEORY]
Course: Fourth Year pharm D
Sr. Topic Hours Planned Actual Medium Remark
No. Date Date
1. Biopharmaceutics
1. Introduction to
Biopharmaceutics
a. Absorption of drugs from
gastrointestinal tract.
b. Drug Distribution.
c. Drug Elimination.
2. Pharmacokinetics
Introduction to
Pharmacokinetics.
a. Mathematical model
b. Drug levels in blood.
c. Pharmacokinetic
model
d. Compartment models
e. Pharmacokinetic study
3. One compartment open model.
a. Intravenous Injection (Bolus)
b. Intravenous infusion.
4 Multicompartment models.
a. Two compartment open
model.
b. IV bolus, IV infusion and oral
administration
5 Multiple – Dosage Regimens.
a. Repititive Intravenous
injections – One Compartment
Open Model
b. Repititive Extravascular
dosing – One Compartment
Open model
c. Multiple Dose Regimen –
KasturiShikshanSanstha
COLLEGE OF PHARMACY, SHIKRAPUR
Approved by PCI, DTE ,MSBTE and Affiliated to SPPU & DBATU
(Id No. PU/PN/B. Pharm/290/2008)
Pratima Nagar, Pune-Nagar Road Shikrapur, Tal: Shirur, Dist: Pune- 412208(MS)
Two Compartment Open Model
6 Nonlinear Pharmacokinetics.
a. Introduction
b. Factors causing Non-linearity.
c. Michaelis-menton method of
estimating parameters.
7 Noncompartmental
Pharmacokinetics.
a. Statistical Moment Theory.
b. MRT for various compartment
models.
c. Physiological
Pharmacokinetic model.
8 Bioavailability and
Bioequivalence.
a. Introduction.
b. Bioavailability study protocol.
c. Methods of Assessment of
Bioavailability
SUBJECT TEACHER HOD PRINCIPAL
KasturiShikshanSanstha
COLLEGE OF PHARMACY, SHIKRAPUR
Approved by PCI, DTE ,MSBTE and Affiliated to SPPU & DBATU
(Id No. PU/PN/B. Pharm/290/2008)
Pratima Nagar, Pune-Nagar Road Shikrapur, Tal: Shirur, Dist: Pune- 412208(MS)
Subject: Subject code: Subject In charge:
BIOPHARMACEUTICS AND
PHARMACOKINETICS [PRACTICAL]
Course: Fourth Year pharm D
Sr. Topic Hours Planned Actual Medium Remark
No. Date Date
1. Improvement of dissolution 03
characteristics of slightly soluble
drugs by some methods
2. Comparison of 03
dissolution studies of two
different marketed products of
same drug
3. Influence of polymorphism on 03
solubility and dissolution.
4 Protein binding studies of a 03
highly protein bound drug and
poorly protein bound drug.
5 Extent of plasma-protein 03
binding studies on the same
drug (i.e. highly and poorly
protein bound drug) at different
concentrations in respect of
constant time.
6 Bioavailability studies of some 03
commonly used drugs on
animal/human model.
7 Calculation of Ka, Ke, t1/2, 03
Cmax, AUC, AUMC, MRT etc.
from blood profile data.
8 Calculation of bioavailability 03
from urinary excretion data for
KasturiShikshanSanstha
COLLEGE OF PHARMACY, SHIKRAPUR
Approved by PCI, DTE ,MSBTE and Affiliated to SPPU & DBATU
(Id No. PU/PN/B. Pharm/290/2008)
Pratima Nagar, Pune-Nagar Road Shikrapur, Tal: Shirur, Dist: Pune- 412208(MS)
two drugs.
9 Calculation of AUC and 03
bioequivalence from the given
data for two drugs.
10 In vitro absorption studies. 03
11 Bioequivalency studies on the 03
different drugs marketed.(eg)
Tetracycline, Sulphamethoxzole,
Trimethoprim, Aspirin etc., on
animals and human volunteers.
12 Absorption studies in animal 03
inverted intestine using various
drugs.
13 Effect on contact time on the 03
plasma protein binding of drugs.
14 Studying metabolic pathways for 03
different drugs based on
elimination kinetics data.
15 Calculation of elimination half- 03
life for different drugs by using
urinary elimination data and
blood level data.
16 Determination of renal 03
clearance.
SUBJECT TEACHER HOD PRINCIPAL
