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Quinoline and Isoquonoline

Quinoline and isoquinoline are used in the production of antimalarial drugs, dyes, and pesticides, while azepines are utilized in manufacturing nylon-6 and hypoglycemic agents. Pyrimidine derivatives serve various medicinal purposes, including antineoplastic, antihyperthyroidism, antibiotic, antifungal, anthelmintic, and antitubercular applications. Pyrrole is noted for its antimicrobial, anticancer, anti-inflammatory, antidiabetic, cardiovascular, antiviral, and antimalarial properties.

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11 views6 pages

Quinoline and Isoquonoline

Quinoline and isoquinoline are used in the production of antimalarial drugs, dyes, and pesticides, while azepines are utilized in manufacturing nylon-6 and hypoglycemic agents. Pyrimidine derivatives serve various medicinal purposes, including antineoplastic, antihyperthyroidism, antibiotic, antifungal, anthelmintic, and antitubercular applications. Pyrrole is noted for its antimicrobial, anticancer, anti-inflammatory, antidiabetic, cardiovascular, antiviral, and antimalarial properties.

Uploaded by

fardinshaikh95033
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Quinoline and

isoquonoline

Uses of Quinoline and


Isoquinoline
Quinoline is used in making antimalarial drugs, dyes,
and pesticides.
Isoquinoline is used in synthesizing alkaloid-based
drugs and dyes.
Beckman rearrangement
It is organic reaction used to convert on oxime to an
omide under acid catalyst by rearrangement
thiozone

Daking reaction

Azepines and purine


USES OF AZEPINES
1) Caprolactam is used as an intermediate in the
manufaturing of nylon-6 and in pro
duction of films, coatings and synthetic leather.
2)Tolazamide drug which is having azepine moiety is
used as a hypoglycemic agent.
Purine Uses of purine
1. Anti-Leishmanial activity :
2. Antiviral activity

Heterocyclic
compound
Pyrimidine
MEDICINAL

USES OF
PYRIMIDINE
Various
pyrimidine derivatives have been developed as
chemotherapeutic agents and
some of the medicinal applications are as follows :
1.Antineoplastic agents: Pyrimidine derivatives
posseses anti-cancer activity for e.g. 5-floro uracil and
5-thioguanine drugs having guanine nucleus like
mercaptopurine thioquanine and azathioprine are also
useful as anti-metabolites. Gemcitabine a pyri-
midine antimetabolite has excellent antitumor activity.
2. Antihyperthyroidism : 2-Thiouracil and its alkyl
derivatives are effective against hy-
perthyroidism. Propyl thiouracil is a drug for
hyperthyroidism with minimum side effects.
3. As antibiotics : Pyrimidines are also example of some
antibiotics. These are active
against mycobacteria and various strains of Gram+ve
and Gram-ve bacteria. For e.g.
Bacimethrin Amicetin etc. Bleomycins & Tubercidine
also belongs to this category.
4. Antifungals : Pyrimidines also have antifungal
properties. Flucytosine is flourinated pyrimidine used in
the treatment of systemic fungal infections.
5.Anthelmentics : For example: Pyrantel pamoate is
effective in the treatment of para-sitic infections. This
drug causes paralysis in helminthes & used in treatment
of infection caused by pinworms & roundworms.
6.Antitubercular agents : Capreomycin is a second line
bacteriostatic drug having pyri-midine ring.

Pyrrole
Reaction

Medical Uses of pyrrole


1.​Antimicrobial and Antifungal Agents:
2.​Anticancer Agents:
3.​Anti-inflammatory and Analgesic Agents:
4.​Antidiabetic Agents:
5.​Cardiovascular Agents:
6.​Antiviral and Antimalarial Agents:

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